| piperlongumine inhibits lmp1/myc-dependent mouse b-lymphoma cells. | piperlongumine (pl), isolated from the fruit of long pepper, piper longum, is a cancer-inhibiting compound that selectively kills tumor cells while sparing their normal counterparts. here we evaluated the efficacy with which pl suppresses malignant b cells derived from a newly developed, double-transgenic mouse model of human endemic burkitt lymphoma (bl), designated mcd40-lmp1/imyc(eμ). pl inhibited tumor cell proliferation in a concentration-dependent manner and induced apoptosis of neoplastic ... | 2013 | 23764397 |
| leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of piper longum. | visceral leishmaniasis or kala-azar is caused by the dimorphic parasite leishmania donovani in the indian subcontinent. treatment options for kala-azar are currently inadequate due to various limitations. currently, drug discovery for leishmaniases is oriented towards rational drug design; the aim is to identify specific inhibitors that target particular metabolic activities as a possible means of controlling the parasites without affecting the host. leishmania salvages pteridin from its host an ... | 2012 | 22752544 |
| leishmanicidal compounds from the fruits of piper longum. | one new alkaloid amide, piperlongumide (1) [n-isobutyl-19-(3',4'-methylenedioxyphenyl)-2e,4e nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of leishmania donovani were isolated from the n-hexane fraction of the fruits of piper longum. the structure of 1 was elucidated by spectroscopic evidences. | 2012 | 22576441 |
| isolation and characterization of antidermatophytic bioactive molecules from piper longum l. leaves. | piper longum l. (piperaceae) commonly known as "long pepper" is a well known medicinal plant in ayurveda. different parts of this plant, such as root, seed, fruit, whole plant etc. are used traditionally in various ailments. here we have investigated the antidermatophytic activity of sequentially extracted petroleum ether, chloroform, methanol and water extracts from p. longum leaf against trichophyton mentagrophytes, t. rubrum, t. tonsurans, microsporum fulvum and m. gypseum. better activity of ... | 2012 | 24293721 |
| experimental evaluation of antipyretic and analgesic activities of amalakyadi gana: an ayurvedic formulation. | in ayurvedic classics, the symptom fever is considered as a separate disease called jwara. acharya sushruta has mentioned amalakyadi gana for treatment of all types of jwara, which contains four drugs namely amalaki (emblica officinalis gaertn.), haritaki (terminalia chebula retz.), pippali (piper longum l.), and chitraka (plumbago zeylenica l.). | 2017 | 27011727 |
| review on medicinal uses, pharmacological, phytochemistry and immunomodulatory activity of plants. | since ancient times, plants have been an exemplary source of medicine. researchers have discovered some important compounds from plants. the present work constitutes a review of the medicinal plants whose immunomodulant activity has been proven. we performed pubmed, embase, google scholar searches for research papers of medicinal plants having immunomodulant activity. medicinal plants used by traditional physicians or reported as having immunomodulant activity include acacia concocinna, camellia ... | 2017 | 25280022 |
| review of scientific evidence of medicinal convoy plants in traditional persian medicine. | one concept used in traditional persian medicine (tpm) for multidrug therapy is that of the convoy drug (mobadregh). according to tpm texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. this study reviewed some convoy drugs presented in tpm, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of p-glycoprotein (p-gp) efflux function, bio ... | 2017 | 27041871 |
| drug-repositioning screening identified piperlongumine as a direct stat3 inhibitor with potent activity against breast cancer. | signal transducer and activator of transcription (stat) 3 regulates many cardinal features of cancer including cancer cell growth, apoptosis resistance, dna damage response, metastasis, immune escape, tumor angiogenesis, the warburg effect and oncogene addiction and has been validated as a drug target for cancer therapy. several strategies have been used to identify agents that target stat3 in breast cancer but none has yet entered into clinical use. we used a high-throughput fluorescence micros ... | 2015 | 24681959 |
| in-vivo and in-vitro activities of medicinal plants on ecto, endo and haemoparasitic infections: a review. | crude methanol, pet. ether, ethyl acetate, n-hexane, dichloromethane and aqueous extracts of various species of medicinal plants have shown significant in-vivo and in-vitro pharmacological activities against ecto, endo and haemoparasites. the scientific evaluations of the use of the plants as antiparasitic agents were based on the claims of folklore drawn from traditional healers from various communities across the world. the pharmacological activities of these plants were associated with the pr ... | 2014 | 23173971 |
| in vitro assessment of the acaricidal activity of piper longum, piper nigrum, and zingiber officinale extracts against hyalomma anatolicum ticks. | ticks and tick-borne diseases are a major constraint for the sustainable cattle industry in the tropical and subtropical regions including the indian subcontinent. the development of resistance to most of the commonly used acaricides leads to an attempt to screen plant extracts and their combinations for their possible acaricidal activity to develop an eco-friendly tick control alternative. an alcoholic and various aqueous extracts of piper longum, piper nigrum and zingiber officinale and their ... | 2017 | 28251408 |
| efficacy of iranian traditional medicine in the treatment of epilepsy. | epilepsy is a brain disorder which affects about 50 million people worldwide. ineffectiveness of the drugs in some cases and the serious side effects and chronic toxicity of the antiepileptic drugs lead to use of herbal medicine as a form of complementary and alternative medicine. in this review modern evidences for the efficacy of antiepileptic medicinal plants in traditional iranian medicine (tim) will be discussed. for this purpose electronic databases including pubmed, scopus, sciencedirect, ... | 2013 | 23936834 |
| ethno-veterinary practices in southern india for captive asian elephant ailments. | india has a long tradition of practicing ayurvedic medicine not only for human ailments, but also for the management of livestock in the form of ethno-veterinary practices. asian elephant is a significant part of indian culture, and ethno-veterinary practices have extended to manage and cure various ailments of asian elephant in captivity. much of this knowledge has been lost in the light of modern practices. | 2017 | 28249821 |
| quantitative determination of catechin as chemical marker in pediatric polyherbal syrup by hplc/dad. | vivabon syrup is a balanced composition of dietary ingredients of phytopharmaceutical nature for maintaining the physique, vigor, vitality and balanced growth of children. the herbal ingredients of pediatric syrup are rich in bioflavonoid, proteins, vitamins, glycosides and trace elements. vivabon is formulated with herbal drugs such as phoenix sylvestris, emblica officinalis, withania somnifera, centella asiatica, amomum subulatum, zingiber officinalis, trigonella foenum-graecum, centaurea behe ... | 2016 | 27165575 |
| antiparasitic efficacy of piperine against argulus spp. on carassius auratus (linn. 1758): in vitro and in vivo study. | argulus are common aquatic ectoparasites that create one of the major threats to aquaculture due to absence of suitable therapy. piperine, a bioactive component of piper longum, has medicinal properties and acts as anti-inflammatory, antibacterial, and antifungal, considering eco-friendliness and cost-effectiveness. the present study aimed to evaluate antiparasitic effect of piperine against an ectoparasite argulus spp. on carassius auratus. artificial argulus infection was carried out by cohabi ... | 2012 | 22864920 |
| anti-snake venom activities of ethanolic extract of fruits of piper longum l. (piperaceae) against russell's viper venom: characterization of piperine as active principle. | piper longum l. fruits have been traditionally used against snakebites in north-eastern and southern region of india. | 2013 | 23506990 |