| plasmodium ovale in liberia. | | 1957 | 13487966 |
| [not available]. | | 1958 | 13561026 |
| unusual length of a plasmodium ovale infection. | | 1958 | 13608056 |
| localization of alkaline phosphatase in the erythrocytic forms of plasmodium ovale. | | 1962 | 13973314 |
| studies on malaria in chimpanzees. x. the presumed second generation of the tissue phase of plasmodium ovale. | | 1963 | 14015114 |
| [plasmodium ovale in french language african territories]. | | 1963 | 14058232 |
| latent infections with plasmodium ovale malaria. | two cases of plasmodium ovale malaria acquired in west africa appeared as primary delayed attacks after one year's continuous residence in canada. both patients took full prophylactic doses of chloroquine before, during, and for several weeks after exposure. the inadequacy of the 4-aminoquinolines for protection against latent benign tertian malaria is noted, and the use of primaquine is recommended. paroxysms occurred in the evening and were accompanied by severe muscle pain, features considere ... | 1965 | 14296004 |
| [detection of plasmodium ovale in moscow among subjects infected in west africa]. | | 1965 | 14345035 |
| the pre-erythrocytic stage of plasmodium ovale. | | 1955 | 14373852 |
| a comparison of west african and west pacific strains of plasmodium ovale. | | 1955 | 14373853 |
| problems in the therapy for imported malaria in the united states. | errors in the diagnosis of imported malaria are increasingly recognized. however, there are few data on the treatment of malaria in the united states. | 2003 | 14504115 |
| plasmepsin 4, the food vacuole aspartic proteinase found in all plasmodium spp. infecting man. | plasmepsins are aspartic proteinases of the malaria parasite, and seven groups of plasmepsins have been identified by comparing genomic sequence data available for the genes encoding these enzymes from plasmodium falciparum, plasmodium vivax, plasmodium knowlesi, plasmodium berghei, and plasmodium yoelii. the food vacuole plasmepsins typified by plasmepsin 4 from p. falciparum (pfpm4) constitute one of these groups. genes encoding the ortholog of pfpm4 have been cloned from plasmodium ovale, pla ... | 2003 | 14550891 |
| procalcitonin serum levels in tertian malaria. | procalcitonin (pct) is closely correlated with parasite burden and clinical outcome in falciparum malaria. the role of pct in tertian malaria has not previously been investigated. | 2003 | 14613513 |
| external quality assessment schemes raise standards: evidence from the ukneqas parasitology subschemes. | the burden of parasitic disease imported into the temperate zone is increasing, and in the tropics remains very high. thus, high quality diagnostic parasitology services are needed, but to implement clinical governance a measure of quality of service is required. | 2003 | 14645352 |
| evaluation of the realart malaria lc real-time pcr assay for malaria diagnosis. | pcr-based methods have advantages over traditional microscopic methods for the diagnosis of malaria, especially in cases of low parasitemia and mixed infections. however, current pcr-based assays are often labor-intensive and not readily quantifiable and have the potential for contamination due to a requirement for postamplification sample handling. real-time pcr can address these limitations. this study evaluated the performance characteristics of a commercial malaria real-time pcr assay (reala ... | 2004 | 14766829 |
| [fourth specie of the malarial parasite in man (plasmodium ovale) and its discovery in the ussr]. | | 1951 | 14837465 |
| a systematic overview of published antimalarial drug trials. | systematic database searches identified 435 antimalarial drug treatment trials, involving 82,616 patients, conducted and published between 1966 and december 2002. of these trials 72% were randomised; 64 (15%) trials involved severe malaria, 47 (11%) studied plasmodium vivax, 3 plasmodium malariae or plasmodium ovale, and the remainder (74%) assessed treatment responses in uncomplicated falciparum malaria. twelve trials (2.7%) specifically evaluated antimalarial treatments in pregnant women. over ... | 2004 | 14964805 |
| malaria relapse and recrudescence among travellers to the tropics. | this study describes 14 cases of relapse and recrudescence of malaria, treated between 1991 and 2003. in that period, 146 patients were hospitalized in the clinic of the institute in gdynia: 20 women and 126 men. in 103 cases the disease was caused by plasmodium falciparum, in 31 cases by plasmodium vivax, in 5 cases by plasmodium malariae, and in 2 cases by plasmodium ovale. five patients were found to have mixed infections, with either p. falciparum and p. vivax or p. falciparum and p. ovale. ... | 2003 | 14974782 |
| development of a real-time pcr assay for detection of plasmodium falciparum, plasmodium vivax, and plasmodium ovale for routine clinical diagnosis. | a taqman-based real-time pcr qualitative assay for the detection of three species of malaria parasites-plasmodium falciparum, p. ovale, and p. vivax-was devised and evaluated using 122 whole-blood samples from patients who had traveled to areas where malaria is endemic and who presented with malaria-like symptoms and fever. the assay was compared to conventional microscopy and to an established nested-pcr assay. the specificity of the new assay was confirmed by sequencing the pcr products from a ... | 2004 | 15004078 |
| multispecies plasmodium infections of humans. | we analyzed point-prevalence data from 19 recent studies of human populations in which either plasmodium ovale or plasmodium vivax co-occur with plasmodium falciparum and plasmodium malariae. although the only statistical interactions among, sympatric congeners are pairwise, the frequencies of mixed-species infections relative to standard hypotheses of species sampling independence show no strong relation to overall malaria prevalence. the striking difference between the p. falciparum-p. malaria ... | 1999 | 10207356 |
| evaluation of a new plate hybridization assay for the laboratory diagnosis of imported malaria in italy. | a new molecular diagnostic method "malaria-ibridogen" (amplimedical s.p.a.--bioline division, turin, italy) based on a plate-hybridization assay for the simultaneous detection and identification of human malaria parasites was evaluated in this study. a target dna sequence of the plasmodial 18s ribosomal rna gene was amplified by polymerase chain reaction (pcr) and hybridized in microtiter wells with five biotinylated probes each specific for plasmodium falciparum, p. vivax, p. malariae, p. ovale ... | 2004 | 15164627 |
| imported tertian malaria resistant to primaquine. | in plasmodium vivax and plasmodium ovale malaria, some of the liver stage parasites remain dormant. the activation of these dormant forms (called hypnozoite) can give rise to relapse weeks, months or years after the initial infection. to prevent relapses, a course of primaquine may be given as terminal prophylaxis to patients. different strains of plasmodium vivax vary in their sensitivity to primaquine and, recently, cases of relapse of plasmodium vivax after this standard primaquine therapy we ... | 1999 | 10461431 |
| [rapid resolution of plasmodium ovale malarial attacks using artesunate (arsumax)]. | this randomized, non-comparative clinical trial without placebo was carried out to assess the efficacy and tolerance of artesunate for treatment of acute plasmodium ovale malarial attacks. thirty cameroonese patients were included. all presented acute plasmodium ovale malarial attacks with parasitemia in excess of 500 asexual forms per mm3. four days after treatment with artesunate, all 30 patients were asymptomatic with no parasitemia. reduction rates were 93.9 p. 100 for asexual forms and 75.4 ... | 1999 | 10472581 |
| how prevalent are plasmodium ovale and p. malariae in east asia? | plasmodium ovale and plasmodium malariae, two of the four human malaria parasites, are usually found at very low prevalence in east asia, even in areas with intense malaria transmission. in this article, fumihiko kawamoto, qing liu, marcelo ferreira and indah tantular review data obtained in recent field surveys, using alternative diagnostic methods such as acridine orange staining and pcr-based methods, to evaluate the prevalence of these two malaria species in east asia. they argue that these ... | 1999 | 10481157 |
| usefulness of seminested multiplex pcr in surveillance of imported malaria in spain. | the use of a new pcr-based method for the diagnosis of malaria in the spanish malaria reference laboratory has promoted an increase in confirmed cases of malaria. from august 1997 to july 1998, a total of 192 whole-blood samples and 71 serum samples from 168 patients were received from the hospitals of the spanish national health system. most of the patients came from west-central african countries (85%). this molecular method showed more sensitivity and specificity than microscopy, detecting 12 ... | 1999 | 10488189 |
| plasmodium ovale in southern africa. | | 1999 | 10492808 |
| malaria "epidemic" in quebec: diagnosis and response to imported malaria. | imported malaria is an increasing problem. the arrival of 224 african refugees presented the opportunity to investigate the diagnosis and management of imported malaria within the quebec health care system. | 2005 | 15632404 |
| cloning and characterization of iron-containing superoxide dismutase from the human malaria species plasmodium ovale, p. malariae and p. vivax. | the iron-containing superoxide dismutase (fesod) gene from three human malaria species, namely plasmodium ovale, p. malariae and p. vivax, was amplified by polymerase chain reaction, cloned and then sequenced. comparisons of their deduced amino acid sequences with that of the fesod from p. falciparum revealed a very low polymorphism at the fesod locus in human malaria species. one p. ovale and the p. vivax fesod genes presented the same nucleotide sequence as that of the p. falciparum strain hb3 ... | 1999 | 10599926 |
| ineffectiveness of the binax now malaria test for diagnosis of plasmodium ovale malaria. | | 2005 | 15695736 |
| erythrocyte fy antigen phenotyping helps differentiate so-called benign tertian malarias. | isolated cases of malaria are increasing in frequency in nonendemic countries. blood film examination remains a mainstay of diagnosis of these sporadic cases because immunologic and molecular methods are unavailable, expensive, and problematic. two tertian malarial species, plasmodium vivax and plasmodium ovale, may appear to be similar morphologically. plasmodium ovale infection is infrequent, and misdiagnosis of this species is common. plasmodium vivax infection can be ruled out, however, if a ... | 2000 | 10656744 |
| [increase of malaria among migrants in amsterdam-zuidoost]. | in a general practice in amsterdam southeast in 1998 a delayed first attack of plasmodium ovale infection was diagnosed in a 13-year-old girl from ghana, malaria tropica with a low parasitaemia index in a 43-year-old ghanaian man and a 8-year-old ghanaian girl, and plasmodium vivax infection in a 44-year-old surinam woman. the ghanaian patients had visited their native country, the surinam woman had contracted the infection during a visit to india. all patients responded well to antimalaria medi ... | 2000 | 10674108 |
| "plasmodium ovale infection in delhi" published in indian journal of pediatrics jan-feb 1999; vol. 66 (1): 143-145. | | 1999 | 10798097 |
| large sequence heterogeneity of the small subunit ribosomal rna gene of plasmodium ovale in cambodia. | plasmodium ovale malaria has been reported in various countries in southeast asia, but never in cambodia. using a species-specific polymerase chain reaction (pcr) targeting the small subunit (ssu) ribosomal rna (rrna) gene, we detected p. ovale in nearly 4% of the inhabitants of a northeastern cambodian village. plasmodium ovale was associated with at least one other plasmodium species, and two quadruple infections were detected. the diagnosis was confirmed by microscopy and by ssu rrna pcr prod ... | 2005 | 15964956 |
| plasmodium ovale infections detected by pcr assay in lao pdr. | plasmodium ovate infection was demonstrated in 5 out of 143 inhabitants in a village in lao pdr by blood microscopy and pcr assay. although the specimen confirmed to be positive for p. ovale by microscopical examination was only one, the target sequences in the 18s rrna genes of malaria parasite detected in all of the five cases were consisted with those of p. ovale by the pcr assay. this is the first report concerning the presence of so many cases with p. ovale infection in lao pdr. | 1999 | 10928349 |
| plasmodium ovale: parasite and disease. | humans are infected by four recognized species of malaria parasites. the last of these to be recognized and described is plasmodium ovale. like the other malaria parasites of primates, this parasite is only transmitted via the bites of infected anopheles mosquitoes. the prepatent period in the human ranges from 12 to 20 days. some forms in the liver have delayed development, and relapse may occur after periods of up to 4 years after infection. the developmental cycle in the blood lasts approxima ... | 2005 | 16020691 |
| plasmodium species mixed infections in two areas of manhiça district, mozambique. | we compared the distribution patterns of individual plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. comparisons concerned circulating plasmodium infections in both human and mosquito vector populations in the dry and wet seasons, at a micro-epidemiological level (households). both areas revealed a very high overall prevalence of infection, all year-round and in all age groups. plasmodium falciparum was the predomin ... | 2005 | 16094461 |
| difficulties in the prevention, diagnosis, and treatment of imported malaria. | imported malaria is quite common in the united states. increasing antimalarial drug resistance and changes in travel patterns may have important implications for the prevention, clinical presentation, and management of this disease. | 2000 | 10979063 |
| epidemiology of highland malaria in western kenya. | to investigate the epidemiology of falciparum malaria in workers from a highland tea plantation in western kenya with very seasonally limited malaria transmission to determine what factors are associated with increased risk of malaria transmission in the kenyan highlands. | 2003 | 16167741 |
| failure of primaquine therapy for the treatment of plasmodium ovale malaria. | | 2005 | 16231275 |
| parasitic procrastination: late-presenting ovale malaria and schistosomiasis. | a 29-year-old woman with ovale malaria (most likely contracted, together with asymptomatic schistosomiasis, in east africa two years previously) had fever, nausea and confusion, jaundice, anaemia, thrombocytopenia, hyponatraemia and hypokalaemia. she was initially diagnosed with and treated for blood-smear-positive vivax malaria. because of the unusual clinical presentation, blood was analysed by a malaria species-specific nested polymerase chain reaction (pcr) assay which identified plasmodium ... | 2001 | 11548081 |
| detection of plasmodium ovale by the ict malaria p.f/p.v. immunochromatographic test. | | 2001 | 11700187 |
| patterns of imported malaria at the academic medical center, amsterdam, the netherlands. | in the netherlands, cases of imported malaria peaked in the late 1990s to around 500 (60% plasmodium falciparum) annually. about 30% to 40% of all cases and 57% to 69% of the falciparum cases presented in the academic medical center, amsterdam. in 1991 to 1994, a shift in population groups to more semi-immune patients, mostly settled immigrants visiting friends and relatives (vfrs), was noticed, when compared to 1979 to 1988. this study shows the ongoing trend in 2000 to 2002. | 2006 | 16412103 |
| real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant plasmodium falciparum malaria in returned travelers. | imported drug-resistant malaria is a growing problem in industrialized countries. rapid and accurate diagnosis is essential to prevent malaria-associated mortality in returned travelers. however, outside of a limited number of specialized centers, the microscopic diagnosis of malaria is slow, unreliable, and provides little information about drug resistance. molecular diagnostics have the potential to overcome these limitations. | 2006 | 16447106 |
| wide distribution of plasmodium ovale in myanmar. | the presence of plasmodium ovale has never been previously reported in myanmar. using blood samples obtained in many villages across the country between 1996 and 2000, molecular diagnosis of plasmodium species was made with semi- or full-nested polymerase chain reaction (pcr) with species-specific primers, followed by agarose gel electrophoresis to detect amplification products. the presence of p. ovale was also confirmed with the another pcr-based diagnosis, the microtiterplate hybridization (m ... | 2002 | 11903985 |
| low autochtonous urban malaria in antananarivo (madagascar). | the study of urban malaria is an area undergoing rapid expansion, after many years of neglect. the problem of over-diagnosis of malaria, especially in low transmission settings including urban areas, is also receiving deserved attention. the primary objective of the present study was to assess the frequency of malaria among febrile outpatients seen in private and public primary care facilities of antananarivo. the second aim was to determine, among the diagnosed malaria cases, the contribution o ... | 2006 | 16573843 |
| epidemiology of malaria in new halfa, an irrigated area in eastern sudan. | a prospective study investigated the epidemiology of malaria in an agricultural area in eastern sudan from november 1999 to june 2000 (1 irrigation and 1 dry season). in monthly parasite surveys, 99/ 1539 blood films from 190 individuals were positive for malaria: 95% for plasmodium falciparum, 3% p. vivax and 2% p. ovale. the slide positive rate (spr) of malaria episodes ranged from 3.7% to 12.8% in different months of the survey, with a peak in january. there was no significant difference in s ... | 2005 | 16602473 |
| stronger host response per parasitized erythrocyte in plasmodium vivax or ovale than in plasmodium falciparum malaria. | fever tends to start at a lower level of parasitemia in plasmodium vivax or ovale than in p. falciparum malaria, but hyperparasitemia and complications are more likely to occur in p. falciparum malaria. therefore, we compared the relationship between parasitemia and host response parameters before therapy in 97 patients with p. faciparum malaria (18 with complications), and 28 with p. vivax or ovale malaria. | 2006 | 16772003 |
| moderate transmission but high prevalence of malaria in madagascar. | malaria transmission remains poorly documented in areas of low transmission. a study has been carried out over two consecutive years in analamiranga, a village located at an altitude of 885m on the western edge of the malagasy highlands, with the aim of generating and updating malariometric indexes for both mosquitoes and schoolchildren. in this village, no vector control measures were performed during the study period nor during previous decades. mosquitoes were collected monthly when landing o ... | 2006 | 16842796 |
| detection and identification of human plasmodium species with real-time quantitative nucleic acid sequence-based amplification. | decisions concerning malaria treatment depend on species identification causing disease. microscopy is most frequently used, but at low parasitaemia (<20 parasites/mul) the technique becomes less sensitive and time consuming. rapid diagnostic tests based on plasmodium antigen detection do often not allow for species discrimination as microscopy does, but also become insensitive at <100 parasites/microl. | 2006 | 17018138 |
| effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in thailand. | primaquine (8-aminoquinoline), the only effective drug to prevent relapses of the persistent liver forms of plasmodium vivax and plasmodium ovale, can induce hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (g6pd) deficiency. the severity varies considerably among affected individuals. three hundred and sixty-four plasmodium vivax cases (342 g6pd-normal and 22 g6pd-deficient) were given a 3-day course of chloroquine (total dose 1,500 mg) followed by primaquine 15 mg a day for ... | 2001 | 12041544 |
| a case of imported plasmodium ovale malaria. | there have been reports in korea of imported malaria cases of four plasmodium species, but there has been no report of imported plasmodium ovale malaria confirmed by molecular biological methods. we report an imported case of that was confirmed by wright-giemsa-stained peripheral blood smear and nested polymerase chain reaction targeting the small subunit ribosomal rna gene. the amplified dna was sequenced and compared with other registered p. ovale isolates. the isolate in this study was a memb ... | 2006 | 17043432 |
| two types of plasmodium ovale defined by ssu rrna have distinct sequences for ookinete surface proteins. | | 2002 | 12106877 |
| space-time clustering of childhood malaria at the household level: a dynamic cohort in a mali village. | spatial and temporal heterogeneities in the risk of malaria have led the who to recommend fine-scale stratification of the epidemiological situation, making it possible to set up actions and clinical or basic researches targeting high-risk zones. before initiating such studies it is necessary to define local patterns of malaria transmission and infection (in time and in space) in order to facilitate selection of the appropriate study population and the intervention allocation. the aim of this st ... | 2006 | 17118176 |
| evaluation of a real-time pcr assay for malaria diagnosis in patients from vietnam and in returned travellers. | real-time pcr diagnosis of malaria has advantages over traditional microscopic methods, especially when parasitaemia is low and when dealing with mixed infections. we have developed a new real-time pcr with specific genes in each plasmodium species present only in one copy to identify the four pathogenic plasmodium spp. for humans. the sensitivity was less than 25 parasites/microl. no cross-hybridisation was observed with human dna or among the four plasmodium spp. using lightcycler pcr and conv ... | 2007 | 17150235 |
| diagnostic criteria and risk factors for plasmodium ovale malaria. | plasmodium ovale is a common malaria parasite in africa, but the epidemiology of p. ovale malaria is poorly known. exposure to malaria, parasitemia, and morbidity were monitored for 6 years among the residents of a village in senegal. the relationship between the level of p. ovale parasitemia and fever risk were analyzed, and diagnostic criteria for clinical p. ovale malaria were established. then the relationships between the occurrence of p. ovale clinical malaria and a series of entomological ... | 2002 | 12195357 |
| comparison of pcr and microscopy for the detection of asymptomatic malaria in a plasmodium falciparum/vivax endemic area in thailand. | the main objective of this study was to compare the performance of nested pcr with expert microscopy as a means of detecting plasmodium parasites during active malaria surveillance in western thailand. | 2006 | 17169142 |
| a retrospective examination of sporozoite-induced and trophozoite-induced infections with plasmodium ovale: development of parasitologic and clinical immunity during primary infection. | a retrospective analysis was made of clinical and parasitologic parameters in patients with induced plasmodium ovale infection to document the initial clinical and parasitologic response and their subsequent development of clinical and parasitologic immunity, and to determine the effect of previous homologous and heterologous malaria on subsequent infection with this parasite. the prepatent periods were relatively uniform. eight patients injected with sporozoites that had been stored frozen had ... | 2002 | 12201582 |
| [two cases of mixed infection of malaria diagnosed by pcr method]. | we here reported two japanese cases of mixed infections of plasmodium species, whose dnas were detected using the pcr test. one case was a 31 year-old male, who presented fever and fatigue, and had a travel history to kenya, cameroon and indonesia. smear test of his peripheral blood found the presence of plasmodium vivax, while nested-pcr diagnosis detected the dnas both p. vivax and plasmodium malariae. the other was a 54 year-old female suffering from general fatigue. she had been treated with ... | 2002 | 12212325 |
| outpatient treatment of malaria in recently arrived african migrants. | to describe the clinical features and management of african migrants recently arrived in western australia and subsequently diagnosed with malaria. | 2006 | 17181500 |
| uk malaria treatment guidelines. | malaria is the tropical disease most commonly imported into the uk, with 1500-2000 cases reported each year, and 10-20 deaths. approximately three-quarters of reported malaria cases in the uk are caused by plasmodium falciparum, which is capable of invading a high proportion of red blood cells and rapidly leading to severe or life-threatening multi-organ disease. most non-falciparum malaria cases are caused by plasmodium vivax; a few cases are caused by the other two species of plasmodium: plasm ... | 2007 | 17215045 |
| malaria and pregnancy: the perspective in pakistan. | to study the effects of malaria on pregnancy outcome. | 2007 | 17319413 |
| genetic polymorphisms influence plasmodium ovale pcr detection accuracy. | detection of plasmodium ovale by use of a nested pcr assay with a novel plasmodium ovale primer set was superior to detection of plasmodium ovale by real-time pcr assays. nested pcr was also better at detecting p. malariae. the detection of p. ovale in many patients first admitted >2 months following their return to italy indicated that p. ovale relapses are common. | 2007 | 17360843 |
| detection of imported malaria with the cell-dyn 4000 hematology analyzer. | the sensitivity and specificity of the cell-dyn 4000 hematology analyzer in the diagnosis of imported malaria were studied with samples from patients in an academic hospital setting. the performance of the cell-dyn 4000 hematology analyzer was compared with that of conventional diagnostic methods for malaria. the cell-dyn 4000 hematology analyzer detected hemozoin-containing depolarizing monocytes in 29 of 58 patients with malaria and 2 of 55 patients without malaria. the presence or absence of ... | 2002 | 12454179 |
| transmission of mixed plasmodium species and plasmodium falciparum genotypes. | we studied malaria transmission by comparing parasite populations in humans and mosquito vectors at the household level. blood samples were collected from all inhabitants for microscopic detection of gametocytes and polymerase chain reaction analysis. the next morning, blood-fed resting mosquitoes were collected inside the bed nets used by the individuals surveyed the previous afternoon. after 8 days of maintenance, mosquitoes were dissected, and midguts and salivary glands were recovered for po ... | 2003 | 12641406 |
| plasmodium malariae and plasmodium ovale--the "bashful" malaria parasites. | although plasmodium malariae was first described as an infectious disease of humans by golgi in 1886 and plasmodium ovale identified by stevens in 1922, there are still large gaps in our knowledge of the importance of these infections as causes of malaria in different parts of the world. they have traditionally been thought of as mild illnesses that are caused by rare and, in case of p. ovale, short-lived parasites. however, recent advances in sensitive pcr diagnosis are causing a re-evaluation ... | 2007 | 17459775 |
| relapsing malaria infection in an adolescent following travel to mozambique. | infection with plasmodium ovale is uncommon in travelers. we describe a case of ovale malaria in a traveler to mozambique who initially presented several weeks after completion of his trip. species identification was ultimately achieved with a pcr-based diagnostic method. | 2007 | 17574150 |
| cross-species regulation of plasmodium parasitemia in semi-immune children from papua new guinea. | malariologists have long been fascinated by the question of whether plasmodium spp. interact in the human host. the first genetic study of the longitudinal dynamics of multiple plasmodium spp. and genotypes in humans has been completed in papua new guinea, where all four plasmodium spp. that infect humans are present. the broad implications of the data from this study are covered here and they show that the total parasite density of plasmodium species oscillates around a threshold and that peaks ... | 2003 | 12798085 |
| primaquine-induced differential gene expression analysis in mice liver using dna microarrays. | primaquine (pq), a clinically important derivative of 8-aminoquinoline used against the hepatic stages (hypnozoites) of plasmodium vivax and plasmodium ovale, was studied to evaluate and compare between mrna expression, and biochemical and histological parameters of hepatic stress in adult swiss mice (mus musculus). following single oral dose of pq (40 mg/kg, bw), alanine aminotransferase (alt) and aspartate aminotransferase (ast) along with hematoxylin and eosin stained liver sections did not s ... | 2007 | 17686563 |
| [triple malaria infection in twin sisters from the democratic republic of congo]. | infections with 3 species of malaria parasites are rarely encountered and observed in less than 0.05% of cases. we came across such an infection in four year-old, monozygote twin sisters, coming from kinshasa (democratic republic of congo). in both of them, parasitemia was low or very low for p. falciparum and p. ovale and of 0.1-0.2% for p. malariae. the twin sisters presented with an iron deficiency anaemia, associated with an heterozygous sickle-cell anaemia and a moderate splenomegaly. the b ... | 2003 | 12836524 |
| evaluation of the intra- and inter-specific genetic variability of plasmodium lactate dehydrogenase. | malaria diagnosis is vital to efficient control programmes and the recent advent of malaria rapid diagnostic tests (rdts) provides a reliable and simple diagnostic method. however a characterization of the efficiency of these tests and the proteins they detect is needed to maximize rdt sensitivity. | 2007 | 17961215 |
| recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four plasmodium species infecting man. | plasmepsin 4 from plasmodium falciparum and orthologs from plasmodium malariae, plasmodium ovale and plasmodium vivax have been expressed in recombinant form, and properties of the active site of each enzyme characterized by kinetic analysis. a panel of chromogenic peptide substrates systematically substituted at the p3, p2, p2' and p3' positions was used to estimate enzyme/ligand interactions in the corresponding enzyme subsites based upon kinetic data. the kinetic parameters kcat, km and kcat/ ... | 2004 | 15287591 |
| parasites resembling plasmodium ovale in strains of plasmodium vivax. | | 1949 | 18142530 |
| [characteristics of malaria cases diagnosed in edirne province between 1994-2002]. | in this study, the epidemiological characteristics of malaria cases in edirne province were investigated. between the years of 1994-2002, a total of 317,087 blood samples were collected from soldiers in the province with selective active surveillance and from the resident population with active or passive surveillance methods, by the medical staff of malaria control department and health centers, to search the presence of plasmodium. in 281 of them plasmodium spp. were detected, and the characte ... | 2004 | 15293910 |
| an indigenous case of plasmodium ovale infection in sri lanka. | plasmodium ovale, which is generally prevalent only in the african region, has been emerging in the asian and southeast asian regions. it has not been reported in sri lanka. we report, to our knowledge, an indigenous case of p. ovale infection in sri lanka. this patient, who was diagnosed by a polymerase chain reaction, had no history of travel overseas or receipt of a transfusion of blood or any blood products, which makes this a likely case of indigenous transmission. this incidental finding o ... | 2008 | 18256413 |
| molecular analysis of plasmodium ovale variants. | complete dna sequences of the small subunit ribosomal rna (ssurrna) gene and partial sequences of three other loci were obtained from three variant-type and three classic-type plasmodium ovale isolates from southeast asia and compared with genbank-available data. three different ssurrna sequences (pov 1-3) were found in each variant-type isolate, and two different ssurrna sequences (poc 1-2) in each classic-type isolate. pov 1-3 were closer to sequences previously found in the cameroon and mal/m ... | 2004 | 15324543 |
| evaluation of fret real-time pcr assay for rapid detection and differentiation of plasmodium species in returning travellers and migrants. | a simple real-time pcr assay using one set of primer and probe for rapid, sensitive and quantitative detection of plasmodium species, with simultaneous differentiation of plasmodium falciparum from the three other plasmodium species (plasmodium vivax, plasmodium ovale and plasmodium malariae) in febrile returning travellers and migrants was developed and evaluated. | 2008 | 18442362 |
| case report: plasmodium ovale infection acquired in malawi. | malaria due to plasmodium ovale is uncommon outside west africa. a 37-year-old male german who had returned from malawi four months previously presented in september 2003 because of fever recurring every two days. the patient had never been to west africa. microscopy of stained thick and thin blood films revealed p. ovale. this is the first report of a p. ovale infection acquired in malawi, east africa. malaria surveillance centres should monitor the possible emergence of autochtonous transmissi ... | 2004 | 15485706 |
| detection of four plasmodium species in blood from humans by 18s rrna gene subunit-based and species-specific real-time pcr assays. | there have been reports of increasing numbers of cases of malaria among migrants and travelers. although microscopic examination of blood smears remains the "gold standard" in diagnosis, this method suffers from insufficient sensitivity and requires considerable expertise. to improve diagnosis, a multiplex real-time pcr was developed. one set of generic primers targeting a highly conserved region of the 18s rrna gene of the genus plasmodium was designed; the primer set was polymorphic enough int ... | 2004 | 15583293 |
| malaria chemoprophylaxis: strategies for risk groups. | the risk of malaria for travelers varies from region to region and depends on the intensity of transmission, the duration of the stay in the area of endemicity, the style of travel, and the efficacy of preventive measures. the decision to recommend chemoprophylaxis to travelers to areas with a low risk of malarial infection is especially difficult because the risk of infection must be balanced with the risk of experiencing side effects. if the risk of side effects by far exceeds the risk of infe ... | 2008 | 18625682 |
| [malaria in the emergency room. results of the emergency treatment of 137 patients with symptomatic malaria]. | to assess characteristics and outcome of emergency patients with acute malaria. | 2005 | 15662580 |
| malaria in refugees from tanzania--king county, washington, 2007. | recent immigrants and refugees constitute a substantial proportion of malaria cases in the united states, accounting for nearly one in 10 imported malaria cases involving persons with known resident status in 2006. this report describes three cases of plasmodium falciparum malaria and two cases of plasmodium ovale malaria that occurred during june 27-october 15, 2007 in king county, washington. the infections were diagnosed in burundian refugees who had recently arrived in the united states from ... | 2008 | 18701876 |
| active-site specificity of digestive aspartic peptidases from the four species of plasmodium that infect humans using chromogenic combinatorial peptide libraries. | two targeted chromogenic octapeptide combinatorial libraries, comprised of 38 pools each containing 361 different peptides, were used to analyze the enzyme/substrate interactions of five plasmepsins. the first library (p1 library) was based on a good synthetic aspartic peptidase substrate [westling, j., cipullo, p., hung, s. h., saft, h., dame, j. b., and dunn, b. m. (1999) protein sci. 8, 2001-2009; scarborough, p. e., and dunn, b. m. (1994) protein eng. 7, 495-502] and had the sequence lys-pro ... | 2005 | 15697202 |
| failure to detect plasmodium vivax in west and central africa by pcr species typing. | plasmodium vivax is estimated to affect 75 million people annually. it is reportedly absent, however, from west and central africa due to the high prevalence of the duffy negative phenotype in the indigenous populations. despite this, non-african travellers consistently return to their own countries with p. vivax malaria after visiting this region. an attempt was made, therefore, to detect the presence of p. vivax parasites in blood samples collected from the indigenous populations of west and c ... | 2008 | 18783630 |
| plasmodium (haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites. | the dna sequence information on avian malaria parasites of the genus plasmodium is quite limited. at present, sequences of only 6 out of 34 valid species are available. however, sequence data of avian malaria parasites are particularly important with regard to the resolution of the phylogenetic relationships of the most virulent human malaria agent, plasmodium falciparum. the question as to whether p. falciparum originates from avian or from mammalian parasites would contribute to our understand ... | 2005 | 15812672 |
| pcr-based detection of plasmodium in anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods. | detection of the four malaria-causing plasmodium species (plasmodium falciparum, plasmodium vivax, plasmodium ovale and plasmodium malariae) within their mosquito hosts is an essential component of vector control programmes. several pcr protocols have been developed for this purpose. many of these methods, while sensitive, require multiple pcr reactions to detect and discriminate all four plasmodium species. in this study a new high-throughput assay was developed and compared with three previous ... | 2008 | 18793416 |
| evaluation and optimization of membrane feeding compared to direct feeding as an assay for infectivity. | malaria parasite infectivity to mosquitoes has been measured in a variety of ways and setting, includind direct feeds of and/or membrane feeding blood collected from randomly selected or gametocytemic volunteers. anopheles gambiae s.l is the main vector responsible of plasmodium falciparum transmission in bancoumana and represents about 90% of the laboratory findings, whereas plasmodium malariae and plasmodium ovale together represent only 10%. | 2008 | 19055715 |
| prevalence of plasmodium spp. in malaria asymptomatic african migrants assessed by nucleic acid sequence based amplification. | malaria is one of the most important infectious diseases in the world. although most cases are found distributed in the tropical regions of africa, asia, central and south americas, there is in europe a significant increase in the number of imported cases in non-endemic countries, in particular due to the higher mobility in today's society. | 2009 | 19138412 |
| glucose-6-phosphate dehydrogenase deficiency in two returning operation iraqi freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria. | use of antimalarial prophylaxis continues to be routine practice among military personnel returning from areas where malaria is endemic. primaquine may be used for terminal prophylaxis against plasmodium ovale and plasmodium vivax. serious complications of this regimen are infrequent. we report the occurrence of significant hemolytic anemia for two soldiers returning from operation iraqi freedom. they presented with dark urine, headaches, and classic laboratory findings of hemolysis. both soldie ... | 2005 | 15916292 |
| [false-negative result with the rapid diagnostic test in plasmodium ovale infection]. | | 2009 | 19386395 |
| towards high-throughput molecular detection of plasmodium: new approaches and molecular markers. | several strategies are currently deployed in many countries in the tropics to strengthen malaria control toward malaria elimination. to measure the impact of any intervention, there is a need to detect malaria properly. mostly, decisions still rely on microscopy diagnosis. but sensitive diagnosis tools enabling to deal with a large number of samples are needed. the molecular detection approach offers a much higher sensitivity, and the flexibility to be automated and upgraded. | 2009 | 19402894 |
| factors influencing the pattern of imported malaria. | data on imported malaria in industrialized areas are known to be incomplete because of underreporting and lack of homogeneity. these facts and the complexity of factors influencing the transmission of malaria render their interpretation difficult. the relevance of various factors is usually not fully considered, although their impact on recommendations for chemoprophylaxis may be important. | 2005 | 15996451 |
| test characteristics of two rapid antigen detection tests (sd fk50 and sd fk60) for the diagnosis of malaria in returned travellers. | two malaria rapid diagnostic tests were evaluated in a travel clinic setting: the sd fk50 malaria ag plasmodium falciparum test (a two-band test) and the sd fk60 malaria ag p. falciparum/pan test (a three-band test). | 2009 | 19416497 |
| preliminary study of malaria incidence in nouakchott, mauritania. | malaria is one of the main motives for outpatient consultation and hospitalization in mauritania. however, its incidence remains unclear because of diagnostic problems and insufficient epidemiological data. | 2009 | 19416545 |
| targeting primaquine into liver using chylomicron emulsions for potential vivax malaria therapy. | primaquine (pq) exerts a broad spectrum of activities against various stages of parasitic malaria. it remains as the only drug that destroys late hepatic stages and latent tissue forms of plasmodium vivax and plasmodium ovale. however, systems that can target pq to liver hepatocytes, where malarial sporozoites reside, are needed to minimize the dose-limiting severe toxicities and side-effects caused by pq. recently, a reconstituted artificial chylomicron emulsion was generated using commercially ... | 2005 | 16140485 |
| evaluation of a real-time polymerase chain reaction assay for the diagnosis of malaria in patients from thailand. | we compared the diagnosis of malaria in 297 patients from thailand by a real-time polymerase chain reaction (pcr) assay using the lightcycler with conventional microscopy using giemsa-stained thick and thin blood films. the pcr assay can be completed in one hour and has the potential to detect and identify four species of plasmodium in a single reaction by use of melting temperature curve analysis (however, we did not detect plasmodium ovale in this study). blood was collected, stored, and trans ... | 2005 | 16282292 |
| late relapse of plasmodium ovale malaria--philadelphia, pennsylvania, november 2004. | approximately 1,300 cases of malaria are reported each year in the united states; nearly all of these cases occur in travelers, many of whom fail to receive or adhere to prescribed chemoprophylaxis or do not follow recommendations for prevention of mosquito bites. malaria can persist if not treated or if treated incorrectly (e.g., with an ineffective drug or an incorrect dosage of an effective drug). early treatment is required to avoid severe illness or death. although malaria typically becomes ... | 2005 | 16340939 |
| implementation of a novel pcr based method for detecting malaria parasites from naturally infected mosquitoes in papua new guinea. | detection of plasmodium species in mosquitoes is important for designing vector control studies. however, most of the pcr-based detection methods show some potential limitations. the objective of this study was to introduce an effective pcr-based method for detecting plasmodium vivax and plasmodium falciparum from the field-caught mosquitoes of papua new guinea. | 2009 | 19646275 |
| longitudinal survey of malaria morbidity over 10 years in saharevo (madagascar): further lessons for strengthening malaria control. | madagascar has been known for having bio-geo-ecological diversity which is reflected by a complex malaria epidemiology ranging from hyperendemic to malaria-free areas. malaria-related attacks and infection are frequently recorded both in children and adults living in areas of low malaria transmission. to integrate this variability in the national malaria control policy, extensive epidemiological studies are required to up-date previous records and adjust strategies. | 2009 | 19660116 |
| value of liu's stain in rapid diagnosis of plasmodium ovale infection. | | 2009 | 19751654 |
| [malaria. primary symptoms: fever, headache, nausea, vomiting, diarrhea]. | | 2006 | 16523989 |