| growth-inhibiting, bactericidal, and urease inhibitory effects of paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of helicobacter pylori. | an assessment was made of the growth-inhibiting, bactericidal, and urease inhibitory activities of paeonol (pa), benzoic acid (ba), methyl gallate (mg), and 1,2,3,4,6-penta-o-galloyl-β-d-glucopyranose (pgg) identified in paeonia lactiflora root, structurally related compounds, and four antibiotics toward three reference strains and four clinical isolates of helicobacter pylori using broth dilution bioassay and western blot. ba and pa showed strong bactericidal effect at ph 4, while mg and pgg we ... | 2012 | 22891951 |
| peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor. | the root part of paeonia lactiflora pall. (ranunculaceae), commonly known as peony, is a commonly used chinese herb for the treatment of depression-like disorders. previous studies in our laboratory have demonstrated that total glycosides of peony (tgp) produced antidepressant-like action in various mouse models of behavioral despair. the present study aimed to examine whether tgp could affect the chronic unpredictable mild stress (cums)-induced depression in mice. the mechanism(s) underlying th ... | 2009 | 19596036 |
| analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine a(1) receptor by inhibiting the extracellular signal-regulated protein kinase (erk) pathway. | paeoniflorin (pf), a chief active ingredient in the root of paeonia lactiflora pall (family ranunculaceae), is effective in relieving colorectal distention (crd)-induced visceral pain in rats with visceral hyperalgesia induced by neonatal maternal separation (nms). this study aimed at exploring the underlying mechanisms of pf's analgesic effect on crd-evoked nociceptive signaling in the central nervous system (cns) and investigating whether the adenosine a(1) receptor is involved in pf's anti-no ... | 2009 | 19664651 |
| neuroprotective effect of a novel chinese herbal decoction on cultured neurons and cerebral ischemic rats. | historically, traditional chinese medicine has been widely used to treat stroke. based on the theory of chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called post-stroke rehabilitation (psr), comprising seven herbs - astragalus membranaceus (fisch.) bunge, salvia miltiorrhiza bunge, paeonia lactiflora pall., cassia obtusifolia l., ligusticum chuanxiong hort., angelica sinensis (oliv.) diels, and glycyrrhiza uralensis fisc ... | 2016 | 27814708 |
| androgen modulators from the roots of paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, japan. | the monoterpene glycoside, 3'-o-galloylpaeoniflorin (1), and four known compounds, 6'-o-galloylalbiflorin (2), pentagalloylglucose (3), 6'-o-benzoylpaeoniflorin (4) and 6'-o-galloylpaeoniflorin (5), were isolated from the roots of paeonia lactiflora that had been grown and processed in nara prefecture, japan, as androgen modulators. their structures were elucidated based on spectroscopic analysis. compounds 2 and 3 showed strong androgen receptor (ar) binding activity (ic(50) values 33.7 and 4.1 ... | 2009 | 19721258 |
| drug-use pattern of chinese herbal medicines in insomnia: a 4-year survey in taiwan. | insomnia is a common complaint in the general population. interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in taiwan. we undertook a survey to define the drug utilization patterns of chinese herbal medicines (cm) for insomnia in taiwan. | 2009 | 19753680 |
| pharmacokinetic comparisons of typical constituents in white peony root and sulfur fumigated white peony root after oral administration to mice. | white peony root and sulfur fumigated white peony root are produced by different processing methods from the root of paeonia lactiflora pall, but the two traditional chinese medicines are used under the same common name white peony root. in order to clarify the influence of sulfur fumigation on pharmacokinetics of the main monoterpene glucoside components in white peony root, an investigation was carried out to compare the pharmacokinetics of sodium paeoniflorin sulfonate (1) and paeoniflorin (2 ... | 2010 | 20051256 |
| the anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in sprague-dawley rats. | paeoniflorin, a component in paeonia lactiflora pall, inhibits nuclear factor-kappab expression in chronic hypoperfusion rat and has anti-inflammatory properties. therefore, the aim of the present study was to investigate the effect of paeoniflorin on cerebral infarct, and the involvement of anti-inflammation. we established an animal model of cerebral infarct by occluding both the common carotid arteries and the right middle cerebral artery for 90 min, followed by reperfusion of 24 hours. the r ... | 2010 | 20128044 |
| synergistic antioxidant activities of eight traditional chinese herb pairs. | many chinese therapeutic herbs that are traditionally used in combination demonstrate significantly better pharmacological effects when used in the combination than when used alone. however, the pharmacological mechanism for this synergism is still not well understood. in the present study, the antioxidant activities of six herbs ((paeonia lactiflora (pl), atractylodes macrocephala (ama), angelica sinensis (as), astragalus membranaceus (ame), glycyrrhiza uralensis (gu) and rheum officinale (ro)) ... | 2009 | 19483308 |
| long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. | the root part of paeonia lactiflora pall., commonly known as peony, is a commonly used chinese herb for the treatment of depression-like disorders. previous studies in our laboratory have showed that total glycosides of peony (tgp) produced antidepressant-like action in various mouse models of behavioral despair. the present study aimed to investigate the mechanism(s) underlying the antidepressant-like action of tgp by measuring neurotrophins including brain-derived neurotrophic factor (bdnf) an ... | 2010 | 20176057 |
| bioactivity-guided isolation of 1,2,3,4,6-penta-o-galloyl-d-glucopyranose from paeonia lactiflora roots as a ptp1b inhibitor. | the inhibition of protein tyrosine phosphatase 1b (ptp1b) is of substantial interest for the treatment of type-2 diabetes mellitus. using an in vitro enzyme assay with human recombinant ptp1b 1,2,3,4,6-penta-o-galloyl-d-glucopyranose was isolated from the roots of paeonia lactiflora as an inhibitor of ptp1b, with an ic(50) value of 4.8 μm. additionally, 1 was shown to act as an insulin sensitizer in human hepatoma cells (hcc-1.2) at a concentration of 10 μm. thus, a potential new mechanism of ac ... | 2010 | 20806783 |
| in vitro bace-1 inhibitory activity of resveratrol oligomers from the seed extract of paeonia lactiflora. | a new resveratrol oligomer (1) together with eight related components (2- 9) were isolated from the seed extract of paeonia lactiflora (paeoniaceae) as active principles responsible for the inhibition of beta-site app-cleaving enzyme 1 (bace-1) in vitro. the chemical structure of 1 was established as (-)-7a,8a- cis- ε-viniferin with the aid of spectroscopic analyses including noesy experiments. all isolated resveratrol oligomers (1- 9) demonstrated significant inhibition on baculovirus-expressed ... | 2010 | 20890809 |
| protective effect of a molecular chaperone inducer, paeoniflorin, on the hcl- and ethanol-triggered gastric mucosal injury. | we previously found that paeoniflorin, a major constituent of paeonia lactiflora pall, could induce heat shock proteins (hsps) in cultured mammalian cells without apparent toxicity (yan et al. 2004). we here investigated the induction of hsps by paeoniflorin in mouse stomach and the effect of paeoniflorin on the hcl- and ethanol-triggered gastric mucosal injury in mouse. | 2010 | 21167840 |
| jakyakgamcho-tang and its major component, paeonia lactiflora, exhibit potent anti-glycation properties. | advanced glycation end products (ages) have been implicated in the pathogenesis of diabetes and other age-related diseases. age inhibitors or breakers, such as aminoguanidine and alagebrium, have been proposed as therapeutic agents for age-related disorders. jakyakgamcho-tang (jgt) is a well-known traditional herbal formula, which consists of the radix of paeonia lactiflora pallas (pr) and the radix and rhizome of glycyrrhiza uralensis fisch (gr). the purpose of this study was to evaluate the in ... | 2016 | 28150470 |
| peoniflorin suppresses tumor necrosis factor-α induced chemokine production in human dermal microvascular endothelial cells by blocking nuclear factor-κb and erk pathway. | peoniflorin (pf) extracted from the root of paeonia lactiflora pall displays anti-inflammation and antioxidant properties in several animal models. chemokines are vital for directing the movement of circulating leukocytes to the sites of inflammation and are involved in the pathogenesis of various inflammatory skin diseases. herein, we investigated the effects and potential mechanisms of pf on tumor necrosis factor-α (tnf-α) induced chemokine production in human dermal microvascular endothelial ... | 2010 | 21190116 |
| paeonia lactiflora pall inhibits bladder cancer growth involving phosphorylation of chk2 in vitro and in vivo. | extracts of paeonia lactiflora pall (rpa), a traditional chinese medicines has been shown to treat cancers. | 2011 | 21396995 |
| effects of total glucosides from paeony (paeonia lactiflora pall) roots on experimental atherosclerosis in rats. | total glucosides of paeony (tgp), compounds extracted from the roots of paeonia lactiflora pall, have been used as an anti-inflammatory drug for the treatment of rheumatoid arthritis (ra) in china. inflammation plays a critical role in the development of atherosclerotic vascular disease. risk of cardiovascular diseases is significantly higher in patients with ra than in normal population. it has a great significance to study the effects of tgp on atherosclerosis. | 2011 | 21453765 |
| paeonia lactiflora inhibits cell wall synthesis and triggers membrane depolarization in candida albicans. | fungal cell walls and cell membranes are the main targets of antifungals. in this study, we report on the antifungal activity of an ethanol extract from paeonia lactiflora against candida albicans, showing that the antifungal activity is associated with the synergistic actions of preventing cell wall synthesis, enabling membrane depolarization, and compromising permeability. first, it was shown that the ethanol extract from p. lactiflora was involved in damaging the integrity of cell walls in c. ... | 2017 | 28100900 |
| influence of paeonia lactiflora roots extract on camp-phosphodiesterase activity and related anti-inflammatory action. | background: paeonia lactiflora root (baishao in chinese) is a commonly used herb in tcm. research has shown baishao to have positive pharmacological actions, including, particularly, anti-inflammatory properties. in this paper we studied the influence of baishao extract on camp-phosphodiesterase (pde) activity and related anti-inflammatory action to identify new pharmacologic action for its clinically widespread use. methods: pde activity was calculated by camp change examined with hplc, respira ... | 2011 | 21782011 |
| anti-viral activity of water extract of paeonia lactiflora pallas against human respiratory syncytial virus in human respiratory tract cell lines. | paeonia lactiflora pallas (p. lactiflora, ranunculaceae) is a common ingredient of sheng-ma-ge-gen-tang (smggt; shoma-kakkon-to) and ge-gen-tang (ggt; kakkon-to). smggt and ggt are different prescriptions of traditional chinese medicine with different ingredients designed for airway symptoms. both smggt and ggt have anti-viral activity against human respiratory syncytial virus (hrsv). therefore, p. lactiflora was hypothesized to be the effective ingredient of both smggt and ggt against hrsv. how ... | 2013 | 23711143 |
| induction of apoptosis in hl-60 cells treated with medicinal herbs. | in order to develop a new apoptosis inducer, we screened 22 crude drugs for their apoptosis-inducing activity. it was found that glycyrrhiza uralensis, cynomorium songaricum, eucommia ulmoides, phellodendron amurense, cinnamomum cassia and paeonia lactiflora induced the death of hl-60 cells. to investigate the mechanism of apoptosis induced by these six crude drugs, the mitochondrial transmembrane potential and the activity of caspase-3 were measured. reduced mitochondrial transmembrane potentia ... | 2003 | 14587878 |
| influence of herbal combinations on the extraction efficiencies of chemical compounds from cinnamomum cassia, paeonia lactiflora, and glycyrrhiza uralensis, the herbal components of gyeji-tang, evaluated by hplc method. | during decoction process, the ingredients of herbal formula interact with each other, such that therapeutic properties and chemical extraction characteristics are altered. the crude drugs, cinnamomum cassia (cc), paeonia lactiflora (pl), and glycyrrhiza uralensis (gu), are the main herbal constituents of gyeji-tang, a traditional herbal formula. to evaluate the chemical interaction between cc, pl, and gu during the course of decoction, quantification of 16 marker compounds in the herbal decoctio ... | 2016 | 27399342 |
| the traditional herbal medicine, ge-gen-tang, inhibits pacemaker potentials by nitric oxide/cgmp dependent atp-sensitive k(+) channels in cultured interstitial cells of cajal from mouse small intestine. | ge-gen-tang (ggt) is a traditional chinese medicinal formula composed of puerariae radix (pueraria lobata ohwi), ephedrae herba (ephedra sinica stapf), cinnamomi ramulus (cinnamomum cassia blume), paeoniae radix (paeonia lactiflora pallas), glycyrrhizae radix preparata (glycyrrhiza uralensis fischer), zingiberis rhizoma (zingiber officinale roscoe), and zizyphi fructus (ziziphus jujuba mill. var. inermis rehder) and is widely used to ameoliorate the symptoms of gastrointestinal (gi) disorders re ... | 2015 | 26003723 |
| traditional herbal formula jakyakgamcho-tang (paeonia lactiflora and glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of stat1 and nf-κb in hacat cells. | a traditional herbal formula jakyakgamcho-tang (jygct; paeonia lactiflora and glycyrrhiza uralensis) has been used for treatment of backache, muscle pain, acute abdominal pain, neuralgia, bronchial asthma, and painful peripheral neuropathy in oriental medicine. we report on our experiments using the hacat human keratinocyte cell line showing that a traditional herbal formula jygct has inhibitory effects on inflammatory responses in skin. stimulation with tumour necrosis factor-alpha (tnf-α) and ... | 2015 | 25765840 |
| anti-inflammatory effects of huangqin tang extract in mice on ulcerative colitis. | huangqintang (hqt) is a traditional chinese formula which is composed of scutellaria baicalensis georgi, paeonia lactiflora pall, glycyrrhiza uralensis fisch, and ziziphus jujube mill. hqt has been used in china for a wide range of disorders, especially in gastrointestinal inflammation with symptoms of nausea, vomiting, diarrhea, abdominal cramps and so on. | 2015 | 25576893 |
| chemical interaction between paeonia lactiflora and glycyrrhiza uralensis, the components of jakyakgamcho-tang, using a validated high-performance liquid chromatography method: herbal combination and chemical interaction in a decoction. | the herbal combination is the basic unit of a herbal formula that affects the chemical characteristics of individual herbs. in the present study, a method of simultaneous determination of the 11 marker compounds in jakyakgamcho-tang was developed using high-performance liquid chromatography with photodiode array detection. the validated analytical method was successfully applied to approach the chemical interaction between paeonia lactiflora and glycyrrhiza uralensis in co-decoction. in p. lacti ... | 2014 | 25044951 |
| pharmacokinetic comparisons of two different combinations of shaoyao-gancao decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid. | shaoyao-gancao decoction (sgd), a well-known traditional chinese medicine prescription, is a combination of radix paeoniae alba (paeonia lactiflora pall, root) and glycyrrhizae uralensis (glycyrrhiza uralensis fisch., root and rhizome, honeyed) for spasmolysis and emergency pain relief. paeoniflorin (pf) and glycyrrhetinic acid (ga) are two typical active components of sgd for pain relief. | 2013 | 23867078 |
| old formula, new rx: the journey of phy906 as cancer adjuvant therapy. | phy906, is a decoction of a mixture of the four herbs scutellaria baicalensis geori, glycyrrhiza uralensis fisch, paeonia lactiflora pall, and ziziphus jujuba mill. a combination of these four herbs has been in continuous use in traditional chinese medicine for over 1800 years for treating a variety of gastrointestinal distress such as diarrhea, cramps, nausea, vomiting etc. | 2012 | 22326673 |
| protective effects of peoniflorin against hydrogen peroxide-induced oxidative stress in human umbilical vein endothelial cells. | peoniflorin (pf), extracted from the root of paeonia lactiflora pall., has been reported to have anti-inflammation and antioxidant effects in several animal models. herein, we investigated the protective effects of pf against hydrogen peroxide (h(2)o(2))-induced oxidative damage in human umbilical vein endothelial cells (huvecs). huvecs were treated by h(2)o(2) (240 µmol/l) with or without pf. pf significantly increased the percent cell viability of huvecs injured by h(2)o(2) using the 3-(4,5-di ... | 2011 | 21777057 |
| growth-inhibiting effects of paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria. | the growth-inhibiting activities of paeonia lactiflora (paeoniaceae) root steam distillate constituents and structurally related compounds against nine harmful intestinal bacteria and eight lactic acid-producing bacteria were compared with those of two antibiotics, amoxicillin and tetracycline. thymol, α-terpinolene, (-)-perilla alcohol and (1r)-(-)-myrtenol exhibited high to extremely high levels of growth inhibition of all the harmful bacteria, whereas thymol and α-terpinolene (except for lact ... | 2012 | 22805939 |
| the antithrombotic effect of rsnk in blood-stasis model rats. | reduction of sheng-nao-kang decoction (rsnk), composed of salvia miltiorrhiza bge., ligusticum chuanxiong hort., astragalus membranaceus (fisch.) bunge., pueraria lobata (willd.) ohwi., paeonia lactiflora pall. and panax notoginseng (burk.) f. h. chen., is a modified traditional chinese medicinal formula of sheng-nao-kang pill preparation, which has been investigated its protective effect on focal cerebral ischemia-reperfusion injury in rat in our previous report. | 2015 | 26216512 |
| in vitro synergistic antioxidant activity and identification of antioxidant components from astragalus membranaceus and paeonia lactiflora. | many traditionally used herbs demonstrate significantly better pharmacological effects when used in combination than when used alone. however, the mechanism underlying this synergism is still poorly understood. this study aimed to investigate the synergistic antioxidant activity of astragalus membranaceus (ame) and paeonia lactiflora (pl), and identify the potential antioxidant components by 1,1-diphenyl-2-picrylhydrazine (dpph) radical spiking test followed by a high performance liquid chromato ... | 2014 | 24816851 |
| identification of multiple ingredients for a traditional chinese medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. | bu-yang-huan-wu-tang (byhwt) is a popular traditional chinese medicine formula consisting of seven herbal medicines (astragalus membranaceus, angelica sinensis, paeonia lactiflora, ligusticum chuanxiong, carthamus tinctorius, amygdalus persica and pheretima aspergillum), that has been used in china for centuries to overcome stroke-induced disability. to ensure the consistency of quality, a reliable analytical method is required, therefore, we developed a liquid chromatography with tandem mass sp ... | 2013 | 24036516 |
| a standardized extract from paeonia lactiflora and astragalus membranaceus induces apoptosis and inhibits the proliferation, migration and invasion of human hepatoma cell lines. | paeonia lactiflora and astragalus membranaceus are two traditional chinese medicines, which are commonly used in chinese herb prescription to treat liver diseases. the protective effects of the extract prepared from the roots of paeonia lactiflora and astragalus membranaceus (pae) on liver fibrosis have been demonstrated in previous studies. however, its effect on hepatocellular carcinoma (hcc) has not been investigated to date. in this study, the effects of pae on the apoptosis, proliferation, ... | 2013 | 24002667 |
| [clinical and experimental studies of effects of huayu decoction on scavenging free radicals]. | infantile pneumonia has been treated successfully with huayu decoction (hyd) in our department for more than ten years. according to the principles of huoxue huayu of tcm, the composition of huayu decoction is as follows: angelica sinensis, paeonia lactiflora, ligusticum wallichii, spathollobus suberectus, hirudo nipponica, tabanus bivittatus, paeonia suffroticosa, astragalus membranaceus . 49 cases of infantile pneumonia were treated with hyd. the activity of erythrocyte superoxide dismutases ( ... | 1993 | 8312693 |
| danggui-shaoyao-san: new hope for alzheimer's disease. | danggui-shaoyao-san (dss), also called toki-shakuyaku-san (tj-23) or dangguijakyak-san (djs), is a well-known herbal formula (angelica sinensis (oliv.) diels., ligusticum chuanxiong hort., paeonia lactiflora pall., poria cocos (schw.) wolf, alisma orientalis (sam.) juzep., atractylodes macrocephala koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. recent studies show that dss has an effect on free radical-mediated neurological diseases ... | 2016 | 27493835 |
| the difference between blood-associated and water-associated herbs of danggui-shaoyao san in theory of tcm, based on serum pharmacochemistry. | danggui-shaoyao san (dss) is a famous chinese formula for activating blood circulation and promoting urination. this study was to investigate the difference of material basis between a blood-associated herbs group and a water-associated herbs group. according to the theory of traditional chinese medicine, the formula can be divided into a blood-associated herbs group (angelica sinensis, paeonia lactiflora and ligusticum chuanxiong) and a water-associated herbs group (atractylodes macrocephala, a ... | 2016 | 26270156 |
| paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability. | objective: the present study aims to explore the effects of paeoniflorin (pf), a monoterpene glycoside isolated from the roots of paeonia lactiflora pallas, on acute lung injury (ali) and the possible mechanisms. materials and method: ali was induced in mice by an intratracheal instillation of lipopolysaccharide (lps, 1 mg/kg), and pf was injected intraperitoneally 30 min prior to lps administration. after 24 h, lung water content, histology, microvascular permeability and proinflammatory cytoki ... | 2011 | 21744312 |
| anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine. | in china, korea, and japan, a decoction of the dried root without bark of paeonia lactiflora pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. a water/ethanol extract of the root is now known as total glucosides of peony (tgp), which contains more than 15 components. paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed wi ... | 2011 | 21687505 |
| paeoniflorin inhibits function of synoviocytes pretreated by ril-1+¦ and regulates ep(4) receptor expression. | ethnopharmacological relevance: to investigate the effect of the paeoniflorin (pae), a main active component of total glucosides of paeony (tgp) extracted from the root of paeonia lactiflora, on regulation of synoviocytes cultured from rats collagen-induced arthritis (cia) in vitro. materials and methods: cia was induced in male sprague-dawley rats immunized with chicken type ii collagen (ccii) in freund's complete adjuvant. the levels of interleukin-1 (il-1), tumor necrosis factor +¦ (tnf-+¦), ... | 2011 | 21840386 |
| Anti-depressant-like effect of peony: a mini-review. | Context: Depression is a common psychiatric disorder, yet the clinical efficacy of antidepression therapies is unsatisfactory. Thus, the search for new anti-depressants continues, and natural products remain a promising source of new therapeutic agents. The root part of Paeonia lactiflora Pall. (Ranunculaceae), known as peony, is often used in Chinese herbal prescriptions for the treatment of depression-like disorders. Objectives: The objective of this review is to provide scientific evidence ... | 2012 | 22196583 |
| paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine. | ethnopharmacological relevance: to investigate the influence of paeoniflorin (major bioactive component of paeonia lactiflora pall.) on the pharmacokinetic behavior of aconitine (major toxic and bioactive component of aconitum carmichaeli debx.) and potential detoxifying effect of paeoniflorin on the acute toxicity of aconitine, which may provide in depth understanding to the toxicity reduction effect of paeonia lactiflora to aconitum carmichaeli. materials and methods: ultra high performance li ... | 2011 | 21930193 |
| prescription of chinese herbal medicine in pattern-based traditional chinese medicine treatment for depression: a systematic review. | traditional chinese medicine (tcm) treatments are often prescribed based on individuals' pattern diagnoses. a systematic review of randomized controlled trials in chinese and english literatures on tcm pattern-based treatment for depression has therefore been conducted. a total of 61 studies, 2504 subjects, and 27 tcm patterns were included. due to the large variation of tcm pattern among participants, we only analyzed the top four commonly studied tcm patterns: liver qi depression, liver depres ... | 2015 | 26180532 |
| digital gene expression analysis to screen disease resistance-relevant genes from leaves of herbaceous peony (paeonia lactiflora pall.) infected by botrytis cinerea. | herbaceous peony (paeonia lactiflora pall.) is a well-known traditional flower in china and is widely used for landscaping and garden greening due to its high ornamental value. however, disease spots usually appear after the flowering of the plant and may result in the withering of the plant in severe cases. this study examined the disease incidence in an herbaceous peony field in the yangzhou region, jiangsu province. based on morphological characteristics and molecular data, the disease in thi ... | 2015 | 26208357 |
| molecular identification of botrytis cinerea, botrytis paeoniae and botrytis pseudocinerea associated with gray mould disease in peonies (paeonia lactiflora pall.) in southern chile. | in chile, the peony is the most important ornamental flower exported from the country. gray mould is a phytopathological problem of this crop. this disease is caused by botrytis cinerea and botrytis paeoniae. | 2016 | 25982419 |
| plant-derived natural medicines for the management of depression: an overview of mechanisms of action. | depression is a serious widespread psychiatric disorder that affects approximately 17% of people all over the world. exploring the neurological mechanisms of the antidepressant activity of plant-derived agents could have a crucial role in developing natural drugs for the management of depression. the aim of the present study is to review the neurological mechanisms of action of antidepressant plants and their constituents. for this purpose, electronic databases, including pubmed, science direct, ... | 2015 | 25719303 |
| an emerging translational model to screen potential medicinal plants for nephrolithiasis, an independent risk factor for chronic kidney disease. | pharmacological therapy for urolithiasis using medicinal plants has been increasingly adopted for the prevention of its recurrence. a drosophila melanogaster model developed for translational research of urolithiasis was applied to evaluate agents with potential antilithic effects and calcium oxalate (caox) formation. potential antilithic herbs were prepared in a mixture of food in a diluted concentration of 5,000 from the original extract with 0.5% ethylene glycol (eg) as the lithogenic agent. ... | 2014 | 25097661 |
| orthogonal array design for optimizing extraction efficiency of active constituents from jakyak-gamcho decoction, the complex formula of herbal medicines, paeoniae radix and glycyrrhizae radix. | a complex formula composed of paeonia lactiflora pall. and glycyrrhiza uralensis fisch., which is called as jakyak-gamcho decoction (jgd), has been used for a pain-relieving function and muscle spasms due to blood deficiency in the traditional medicine. in this study, the anti-inflammatory activity of jgd was evaluated based on the quantitative determinations and the relative proportions of six major constituents in the decoction mixture extracted by orthogonal array methods. our results suggest ... | 2007 | 17681441 |
| dynamic analysis of the endogenous metabolites in depressed patients treated with tcm formula xiaoyaosan using urinary (1)h nmr-based metabolomics. | xiaoyaosan (xys), one of the best-known traditional chinese medicine prescriptions with a long history of use, is composed of bupleurum chinense dc., paeonia lactiflora pall., poria cocos (schw.) wolf, angelica sinensis (oliv.) diels, zingiber officinale rosc., atractylodes macrocephala koidz., glycyrrhiza uralensis fisch., and mentha haplocalyx briq. for centuries, xys has been widely used in china for the treatment of mental disorders such as depression. however, the complicated mechanism unde ... | 2014 | 25448502 |
| [clinical observation of breast hyperplasia treated with auricular point sticking therapy and xiaopijian]. | to observe the efficacy difference in the treatment of breast hyperplasia between the combined therapy of auricular point sticking and xiaopijian and the simple application of xiaopijian. | 2015 | 26571890 |
| inhibitory effects of korean indigenous plants on tyrosinase and melanogenesis. | to search for new depigmenting cosmetic ingredients from korean herbal extracts of traditional korean medicines (tkms), we screened about 17 tkm extracts collected in the republic of korea. samples were prepared from the natural plants, including medicinal plants such as chrysanthemum indicum (flower), using methanol, methylene chloride, ethyl acetate (etoac), n-butyl alcohol, and water as the extraction and/or the partitioning solvents. we then tested their inhibitory effects on melanogenesis b ... | 2013 | 23578837 |
| ameliorating effects of herbal formula hemomine on experimental subacute hemorrhagic anemia in rats. | hemomine (hm) is an herbal mixture consisting of 5 varieties of the hematopoietic herbal extracts (angelica gigas nakai, cnidium officinale makino, paeonia lactiflora pall., rehmannia glutinosa liboschitz ex stueudel, glycyrrhiza uralensis fischer). | 2017 | 28089715 |
| food- and gender-dependent pharmacokinetics of paeoniflorin after oral administration with samul-tang in rats. | samul-tang (si-wu-tang in chinese, shimotsu-to in japanese), widely used in eastern asia, is composed of angelica gigas (angelicae gigantis radix), cnidium officinale (cnidii rhizoma), paeonia lactiflora (paeonia radix) and rehmannia glutinosa (rehmanniae radix preparata). paeoniflorin, one of active components in samul-tang has anti-platelet, anti-inflammation, anti-cancer and neuroprotective properties. however, there is no information about the effects of gender and food intake on the pharmac ... | 2012 | 22543167 |