| helicobacter heilmannii related gastric ulcer in childhood. | | 2003 | 12604985 |
| helicobacter heilmannii gastritis: association with acid peptic diseases and comparison with helicobacter pylori gastritis. | we analyzed 2 antral and 1 corpus full-thickness random endoscopic gastric mucosal samples obtained from 946 patients with duodenal ulcers (6077 biopsies) and from 281 patients with nonsteroidal anti-inflammatory drug-associated gastric ulcers (1794 biopsies). we stained tissue sections with hematoxylin and eosin and warthin-starry silver stain and immunostained them with polyclonal antibodies against helicobacter pylori. hematoxylin- and eosin-stained sections from 6 patients with helicobacter ... | 1999 | 10349993 |
| [massive duodenal lambliasis and helicobacter heilmannii gastritis in a diabetic patient]. | | 1999 | 10365181 |
| [helicobacter heilmannii: anatomo-clinical study of 14 new cases]. | introduction: helicobacter pylori is one of the most common causes of human gastritis. recently, a new agent has been isolated, which also causes a gastritis. it has been initially named gastrospirillum hominis and renamed helicobacter heilmannii (hh). hh is extremely rare. in spite of the rarity it is important to recognize and diagnose it, as it requires a proper therapy, different from hp therapy. clinical presentation and serological results of hh are superimposable to those of hp. therefore ... | 1999 | 10396946 |
| helicobacter pylori and helicobacter heilmannii in children. a bulgarian study. | the aim of the study was to evaluate the prevalence of helicobacter pylori and helicobacter heilmannii among 321 children. gram staining, urease test and culture were performed. of all patients, 52.6% were h. pylori positive and 0.3% were h. heilmannii positive. h. pylori infection was associated with chronic gastritis in 57.1%, with duodenal ulcer in 75% and with non-ulcer dyspepsia in 25.6%. this infection was more frequent in children aged 11-18 years than in younger patients. rapid urease te ... | 2003 | 12944015 |
| [chronic gastritis in helicobacter heilmannii infection]. | the presence of helicobacter pylori in the gastric mucosa used to be associated with gastritis and peptic ulcer. helicobacter heilmannii is a similar but much less frequent and less known gastric pathogen. | 1999 | 10422341 |
| [a case of gastric ulcer induced by helicobacter heilmannii-like organism]. | recently, there was growing interest in a gastric spiral-shaped bacterium morphologically deviating from helicobacter pylori (h. pylori), which was classified as helicobacter heilmannii (h. heilmannii). it rarely inhabits human species whereas the observation of structurally comparable bacteria in other mammals, including cats and dogs, is a commonplace. therefore, it is now generally recognized that h. heilmannii is an animal helicobacter, which is occasionally transmitted to man. h. heilmannii ... | 2003 | 14532733 |
| images in pathology: helicobacter heilmannii gastritis. | | 2003 | 14615829 |
| multiplex pcr assay for differentiation of helicobacter felis, h. bizzozeronii, and h. salomonis. | helicobacter felis, helicobacter bizzozeronii, and helicobacter salomonis are frequently found in the gastric mucous membrane of dogs and cats. these large spiral organisms are phylogenetically highly related to each other. their fastidious nature makes it difficult to cultivate them in vitro, hampering traditional identification methods. we describe here a multiplex pcr test based on the trna intergenic spacers and on the urease gene, combined with capillary electrophoresis, that allows discrim ... | 2004 | 15004062 |
| [helicobacter heilmannii ulceronecrotic acute gastritis: apropos of 5 cases ]. | we report 5 cases of helicobacter heilmannii associated ulceronecrotic gastritis in patients presenting with acute epigastric pain. these bacteria were known to be associated with chronic active gastritis, less severe than those associated with helicobacter pylori. helicobacter heilmannii appears as spiral shaped organisms larger and longer but less numerous than helicobacter pylori. our five patients were cured by 4 weeks treatment with proton-pomp inhibitors without antibiotics. endoscopic con ... | 2000 | 11148357 |
| [helicobacter heilmannii in the pathology of the stomach and duodenum]. | historical aspects of the discovery of the spiral-like non-spirochetal bacteria belonging to helicobacter and called helicobacter heilmannii (hh)--previous name gastrospirillum hominis--and producing under some conditions, like helicobacter pylori, analogous gastroduodenal pathology (chronic gastritis, gastric ulcer, malt-lymphoma and stomach cancer) are presented. microbiological and structural features of this agent are considered as well as its relations with an apical surface of epitheliocyt ... | 1999 | 10476352 |
| helicobacter heilmannii gastroduodenal disease and clinical aspects in children with dyspeptic symptoms. | to evaluate the occurrence and clinical characteristics of helicobacter heilmannii infection among children presenting with dyspeptic symptoms. | 2004 | 15174799 |
| malt lymphomas and helicobacter pylori? | | 2001 | 11211858 |
| helicobacters of possible zoonotic origin: a review. | since the isolation of helicobacter pylori, many new helicobacter species have been identified from the gastrointestinal tract in humans and animals. in humans, a spiral organism different from h. pylori and provisionally named "helicobacter heilmannii", has been associated with gastritis, gastric ulceration and to a lesser degree, gastric cancer. in addition helicobacter cinaedi, helicobacter fennelliae, helicobacter pullorum and "flexispira rappini" have been isolated from cases of enteric dis ... | 2000 | 11233522 |
| helicobacter heilmannii. | | 2001 | 11264502 |
| comparison of gastritis and gastric epithelial proliferation in helicobacter heilmannii-infected nude and balb/c mice. | gastric mucosal hypertrophy/nodular hyperplasia occurs as a consequence of helicobacter infection in mice and humans. the pathogenesis of this hyperplastic response is not understood. to determine the role of host cellular immunity in gastric mucosal hypertrophy/hyperplasia, 6-8-week-old female euthymic balb/c (n = 30) or nih athymic nude (n = 40) mice were inoculated with h. heilmannii. equal numbers of uninoculated mice of each strain served as controls. mice from each group were euthanatized ... | 2001 | 11280373 |
| persistent increase in myofibroblasts in helicobacter heilmannii-infected mice but not in helicobacter pylori-infected mongolian gerbils: colocalization of cox-2 and bfgf immunoreactivity. | the clinical significance of helicobacter heilmannii infection remains uncertain, owing to the lack of a specific detection method. recently, we reported a marked increase in myofibroblasts in the early stage of helicobacter pylori infection in monglian gerbils. | 2002 | 11966538 |
| [helicobacter heilmannii-associated gastritis]. | | 2002 | 11979890 |
| characteristics and prevalence of helicobacter heilmannii infection in children undergoing upper gastrointestinal endoscopy. | helicobacter heilmannii, described in 1983 as a new cause of chronic gastritis, has been reported rarely in children. the purpose of this study was to determine the clinical characteristics and the prevalence of h. heilmannii infection, in comparison with helicobacter pylori infection in children undergoing upper digestive endoscopy. | 1999 | 10554119 |
| first report on the occurrence of 'helicobacter heilmannii' in the stomach of rabbits. | gastric helicobacter spp. have been described in a wide range of animal species, including dogs, cats, primates, swine, cattle and rodents. however, in lagomorphs--more specifically rabbits--gastric helicobacter infections have never been reported. biopsy specimens were collected from different stomach regions of 23 rabbits, including 10 pet rabbits, 10 industrial animals and 3 research animals. these were subjected to a pcr assay for the detection of helicobacter dna. identification up to the s ... | 2005 | 15751578 |
| cellular immune responses in helicobacter heilmannii infection: evaluation of the role of the host and the bacterium. | we evaluated some aspects of the immune response to helicobacter heilmannii in two mouse strains. gastritis that was more severe in infected c57bl/6 mice. a proliferative response to h. pylori antigens was observed in splenocytes from h. heilmannii-positive and -negative mice, similar in the positive- and negative-balb/c mice, but lower in the positive- than in the negative-c57bl/6 animals. a decrease in b cells and an increase in cd4+ cells after stimulation with type i h. pylori antigen and an ... | 2002 | 11991617 |
| [helicobacter heilmannii-associated low-grade gastric malt lymphoma: a new case of complete remission after eradication]. | | 2005 | 15918221 |
| helicobacter heilmannii-associated primary gastric low-grade malt lymphoma: complete remission after curing the infection. | cure of helicobacter pylori infection may lead to complete remission of associated low-grade mucosa-associated lymphoid tissue (malt) lymphoma in stage ei. this study investigated whether helicobacter heilmannii infection-associated primary gastric malt lymphoma will regress after cure of the infection. | 2000 | 10784580 |
| gastric mucosa-associated lymphoid tissue lymphoma: implications of animal models on pathogenic and therapeutic considerations--mouse models of gastric lymphoma. | there are a number of helicobacter species that will readily colonise the mouse stomach for the duration of the animal's life. they are helicobacter felis, "helicobacter heilmannii" and helicobacter pylori. early studies on long-term infection of balb/c mice showed the presence of lesions resembling low-grade gastric mucosa-associated lymphoid tissue (malt) lymphoma. because of the suggestion that h. pylori was the cause of these tumors in humans, this phenomenon was studied further as it was re ... | 2000 | 10802862 |
| helicobacter felis does not stimulate human neutrophil oxidative burst in contrast to 'gastrospirillum hominis' and helicobacter pylori. | helicobacter pylori is a human pathogen, whereas the natural hosts for 'gastrospirillum hominis' and helicobacter felis are animals. 'g. hominis' is occasionally found to cause infection in humans, whereas h. felis only rarely infects humans. the pathogenesis of h. pylori infection is not completely understood and in order to reveal differences in immune response to the three helicobacter species, the upregulation of adherence molecule cd11b/cd18, chemotactic activity and oxidative burst respons ... | 2001 | 11335137 |
| growth of helicobacter pylori in a long spiral form does not alter expression of immunodominant proteins. | we have previously reported that altered culture conditions (a broth media with shaking) could induce a strain of helicobacter pylori to assume a long spiral morphology resembling that described for helicobacter heilmannii. the present study was initiated to determine if other strains of h. pylori could be induced to assume that morphology and if doing so would alter the expression of immunodominant proteins. | 2002 | 12213186 |
| increased gastric emptying induced by helicobacter heilmannii type 1 infection in rats. | the association between helicobacter pylori infection and gastric motility abnormalities is still controversial, partly because of the lack of an appropriate animal model. h. heilmannii type 1 (hh1), a spiral bacterium that infects the stomach of both man and pigs, easily colonises and induces an inflammatory response in the gastric mucosa of rodents. for these reasons, the present study investigated the relationship between gastric motility in rats experimentally infected with hh1 and correlate ... | 2000 | 10882088 |
| a case of acute gastric mucosal lesions associated with helicobacter heilmannii infection. | a 69-year-old-woman presented with acute epigastric pain, nausea, vomiting and heartburn. endoscopy disclosed acute gastric mucosal lesions including mucosal edema, erosions, and ulcers with blood crusts in the antrum. touch cytology and histological assessment obtained from the affected mucosa revealed acute neutrophilic gastritis and single longer and more coiled organisms than helicobacter pylori, suggesting helicobacter heilmannii. electron micropragh confirmed the characteristic morphology. ... | 2002 | 12390213 |
| helicobacter heilmannii gastritis: a case study with review of literature. | h. heilmannii belongs to the helicobacter family and is found in a small number of gastric biopsies. this bacterium is generally found in primates, cats, pigs, and carnivorous mammals. about 0.5% to 6% of human gastric infections have been attributed to h. heilmannii. the bacterium usually induces mild chronic gastritis but may be associated with peptic ulceration, and rare cases were reported in association with gastric carcinoma and mucosa-associated lymphoid tissue lymphoma. we report a case ... | 2005 | 16224223 |
| evaluation of antibiotic treatment against "candidatus helicobacter suis" in a mouse model. | "helicobacter heilmannii" (proposed name) type 1 colonizes the human stomach. it has been shown to be identical to "candidatus helicobacter suis," a helicobacter species colonizing the stomachs of >60% of slaughter pigs. this bacterium has not been isolated in vitro until now. antibiotic susceptibility testing of "candidatus helicobacter suis" has not been carried out so far. for the present study, a mouse model was adopted to evaluate the antibiotic susceptibility of this organism. mice infecte ... | 2005 | 16251292 |
| the updated sydney system: classification and grading of gastritis as the basis of diagnosis and treatment. | in recent years, the importance of the histological diagnosis of gastritis on the basis of routinely obtained antral and corpus biopsies has increased enormously, which is owed not least of all to the discovery of helicobacter pylori. the introduction of the sydney system made it possible, for the first time, to grade histological parameters, identify topographical distribution and, finally, make a statement about the etiopathogenesis of the gastritis. of pathogenetic importance is, in the first ... | 2001 | 11573102 |
| [biological diagnostic and therapeutic study on the infection of helicobacter heilmannii]. | to study the epidemiology, microbiology, pathogenicity, diagnosis and therapy of helicobacter heilmannii (hh) infection. | 1998 | 10923454 |
| [14-years old boy with chronic gastritis]. | | 1995 | 11785202 |
| high prevalence of helicobacter heilmannii-associated gastritis in a small, predominantly rural area: further evidence in support of a zoonosis? | primary hosts of helicobacter heilmannii are domestic animals--cats, dogs and pigs, but rarely is it detected in gastric biopsies from humans. we found h. heilmannii in gastric biopsies obtained from patients living in a predominantly rural area. | 2000 | 11063150 |
| helicobacter pylori-negative peptic ulcer. what is its aetiopathogenesis and treatment? | although the vast majority of peptic ulcers are widely considered as related to the germ helicobacter pylori, ulcers exhibiting absence of this infection are increasingly seen in recent years. this fact has been partly related to a decreased prevalence of helicobacter pylori among the population, a consequence of improved hygiene and housing conditions. causes in relation to helicobacter pylori-negative ulcers are: 1. falsely negative infection diagnostic tests. they represent 25% of ulcers cons ... | 2002 | 12690992 |
| acute symptomatic gastritis due to helicobacter heilmannii. | helicobacter heilmannii is a gram-negative spiral-shaped organism predominantly associated with zoonotic infection. human pathology has also been described, but acute symptoms with complete resolution have been infrequently reported. we present a 50-year-old man in whom h. heilmannii gastritis presented as an acute febrile illness and was successfully treated with antibiotics and proton pump inhibitor. epidemiology, diagnosis, and treatment of similar cases are reviewed. | 2006 | 16961807 |
| gastritis and carditis. | dyspepsia is a common clinical problem. its causes include peptic ulcer disease, gastroesophageal reflux, and functional (nonulcer) dyspepsia. a detailed clinical description of pain does not reliably differentiate the cause. approximately 80% of gastroscopies are performed for the investigation of dyspepsia. "gastritis" is diagnosed endoscopically in 59% of all stomachs, although in only 3% are the changes severe. pathologic examination of unselected gastric biopsy specimens reveals that abnorm ... | 2003 | 12692198 |
| development and application of a novel screening pcr assay for direct detection of 'helicobacter heilmannii'-like organisms in human gastric biopsies in southeast england. | a novel pcr assay (hhlo-16) to screen for presence of 'helicobacter heilmannii'-like organisms (hhlo) direct from gastric biopsies is described. as 'h. heilmannii' is generally uncultivable, diagnosis of infection is reliant on histology; thus prevalence may be underestimated. analysis of an hhlo histology-positive human gastric biopsy and 15 gastric biopsies from domestic cats demonstrated that the hhlo-16 assay was more sensitive than an alternative available species-specific pcr assay. furthe ... | 2003 | 12742311 |
| acute phlegmonous gastritis associated with helicobacter heilmannii infection in a child. | | 2006 | 17103036 |
| gastritis associated with helicobacter-like organisms in baboons. | subclinical gastritis was observed in 10 of 10 baboons (papio spp.) from a toxicity study in a research facility. the lesions were similar in xenobiotic-treated and control animals, suggesting a spontaneous rather than chemical-induced disease. histologic examination revealed lymphoplasmacytic gastritis in the antral mucosa. the fundic mucosa contained minor, scattered aggregates of lymphocytes and plasma cells. a warthin-starry silver stain and ultrastructural examination revealed numerous spir ... | 2003 | 12949414 |
| discovering new pathogens: culture-resistant bacteria. | recent advances in gene-amplification technology and molecular phylogenetics have provided the means of detecting and classifying bacteria directly from their natural habitats without the need for culture. these techniques have revolutionized environmental microbiology, and it is now apparent that the global diversity of microorganisms is much greater than previously thought. in the context of clinical microbiology, this molecular-based approach has facilitated the characterization of culture-re ... | 2004 | 15148425 |
| gastric b-cell mucosa-associated lymphoid tissue (malt) lymphoma in an animal model of 'helicobacter heilmannii' infection. | while helicobacter pylori is accepted as the dominant human gastric bacterial pathogen, a small percentage of human infections have been associated with another organism, commonly referred to as 'helicobacter heilmannii', which is more prevalent in a range of animal species. this latter bacterium has been seen in association with the full spectrum of human gastric diseases including gastritis, peptic ulceration, and gastric carcinomas, including gastric b-cell mucosa-associated lymphoid tissue ( ... | 2004 | 15258991 |
| helicobacter heilmannii reinfection in a helicobacter pylori negative adolescent: a 4-year follow-up. | | 2007 | 17245224 |
| the relationship of a helicobacter heilmannii infection to the mucosal changes in abattoir and laboratory pig stomach. | a pig ulcer model in which ulceration is reproducibly induced in the pars oesophagea (a tongue of the oesophageal squamous epithelium that extends into the pig stomach) by bile duct ligation (bdl) was used in this study to determine whether helicobacter heilmannii (hh) is a predisposing factor in the ulceration of this region. the infection with hh and its relationship to ulceration and mucus integrity was examined. | 2004 | 15526130 |
| increased apoptosis and angiogenesis in gastric low-grade mucosa-associated lymphoid tissue-type lymphoma by helicobacter heilmannii infection in c57/bl6 mice. | helicobacter heilmannii has been reported to cause gastric low-grade mucosa-associated lymphoid tissue-type (malt) lymphoma, but its precise pathophysiological mechanism remains to be clarified. we recently established a model of gastric b-cell malt lymphoma in c57bl/6 mice by means of peroral infection of h. heilmannii primarily obtained from cynomolgus monkeys. using this model, macroscopic, immunohistochemical, and electron microscopic observations of malt lymphomas were carried out in order ... | 2007 | 17488330 |
| helicobacter pylori and helicobacter heilmannii in untreated bulgarian children over a period of 10 years. | the aims of the study were to evaluate the incidence of helicobacter pylori and helicobacter heilmannii in untreated bulgarian children from 1996 to 2006, to analyse the performance of diagnostic tests, and to look at h. pylori density in specimens by culture. antral specimens from children with chronic gastritis (n=513), peptic ulcers (n=54) and other diseases (n=91) were evaluated by direct gram staining (dgs), in-house rapid urease test (rut) and culture. the living environment and semi-quant ... | 2007 | 17644716 |
| detection of helicobacter pylori infection in symptomatic bulgarian adults. | this study assessed the prevalence of helicobacter pylori in symptomatic bulgarian adults by means of culture, gram's stain and an in-house rapid urease test (rut), and also assessed the h. pylori density by culture. in total, 1441 non-treated and 270 treated patients were evaluated. most non-treated patients with ulcers (87.7%), gastric malignancy (79.2%) and other gastroduodenal diseases (73.4%) were h. pylori-positive. among non-treated and treated patients, 75.3% and 54.8%, respectively, of ... | 2007 | 17686140 |
| prevalence of 'candidatus helicobacter suis' in pigs of different ages. | samples from the antrum and fundus of the stomachs of 457 pigs from 22 different herds were screened for the presence of 'candidatus helicobacter suis' by pcr, and samples from the antrum and/or fundus of 222 of the stomachs were tested for urease activity. the prevalence of the infection was very low before weaning, increased rapidly after weaning and reached 90 per cent in the adult boars and sows. the agreement between the results obtained with the pcr test and the urease test was very good f ... | 2007 | 17693628 |
| description of 'candidatus helicobacter heilmannii' based on dna sequence analysis of 16s rrna and urease genes. | while helicobacter pylori is accepted as the major bacterial agent of gastric disease in humans, some patients and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as 'helicobacter heilmannii' or 'gastrospirillum hominis'. taxonomic classification of these bacteria has been hampered by the inability to cultivate them in vitro and by the inadequate discriminatory power of 16s rrna gene sequence analysis. this study describes the detection and phylog ... | 2004 | 15545459 |
| acute gastritis associated with invading helicobacter heilmannii organisms from a previously homeless cat. | | 2008 | 18209598 |
| the high prevalence of helicobacter sp. in porcine pyloric mucosa and its histopathological and molecular characteristics. | this study examined the prevalence of helicobacter infection in the pyloric mucosa of pigs and its histopathological and molecular characteristics. forty porcine pyloric samples were examined for helicobacter infection by silver staining and pcr assay. the pcr product (376 bp) was digested with ndeii to differentiate between helicobacter heilmannii and helicobacter pylori. another pcr assay run to produce an 1157 bp fragment was performed using a primer set designed from the 16s rrna gene of can ... | 2004 | 15564031 |
| helicobacter heilmannii infection in a child. | | 2004 | 15578901 |
| evaluation of antibiotic therapy for eradication of "candidatus helicobacter heilmannii". | triple-agent therapy with lansoprazole (15 mg/kg)-clarithromycin (50 mg/kg)-amoxicillin (50 mg/kg) twice daily for 7 days fully cleared "candidatus helicobacter heilmannii" from infected mouse stomachs. moreover, gastric mucosa-associated lymphoid tissue lymphoma-like lesions in the stomach nearly disappeared in the treated mice 4 months after the therapy. | 2008 | 18490502 |
| helicobacter heilmannii infection in a child after successful eradication of helicobacter pylori: case report and review of literature. | an 11-year-old boy with helicobacter pylori-associated duodenal ulcer was successfully treated with a combination of lansoprazole, amoxicillin, and clarithromycin. endoscopy and gastric biopsies were repeated 2 and 12 months later, showing ulcer healing and eradication of h. pylori. however, a 3-year follow-up study demonstrated h. heilmannii in the antral mucosa based on its characteristic morphology and positive urease test and negative culture. the patient had no contact with domestic animals ... | 2005 | 15692795 |
| gastric lesions and immune responses caused by long-term infection with helicobacter heilmannii in c57bl/6 mice. | helicobacter heilmannii is a gastric micro-organism that can induce gastritis and b-cell malt (mucosa-associated lymphoid tissue) lymphoma in mice, in a host-dependent manner. the present study was designed to examine gastric lesions and immune responses caused by intragastric h. heilmannii infection of an inbred mouse strain, c57bl/6. long-term infection led to the formation of gastric nodules and increased mucosal thickness of the stomach, due to gastric epithelial proliferation. infection als ... | 2008 | 18823636 |
| [repeated abdominal pain in an 11 year old. cats or stress?]. | | 2004 | 15700587 |
| development of a microelectronic chip array for high-throughput genotyping of helicobacter species and screening for antimicrobial resistance. | a microelectronic array assay was developed to specifically genotype helicobacter pylori versus helicobacter heilmannii and to determine antimicrobial resistance. helicobacter 16s rrna and 23s rrna genes were specifically generated with helicobacter genus-specific primers, respectively. the single-nucleotide polymorphisms (snps) in 16s rrna, 268t specific in the h. pylori sequence, and 263a specific in h. heilmannii were used as molecular markers for identification of h. pylori and h. heilmannii ... | 2005 | 15809319 |
| helicobacter heilmannii infection: clinical, endoscopic and histopathological features in japanese patients. | gastric biopsy materials of 4074 consecutive japanese patients undergoing esophagogastroduodenoscopy were reviewed, along with those of 15 patients with helicobacter heilmannii infection (11, chronic gastritis; four, mucosa-associated lymphoid tissue (malt) lymphoma). in four patients with h. heilmannii infection, the materials were examined by transmission electronmicroscopy. urea breath test (three patients) and antibody test (five patients) were performed in patients with h. heilmannii infect ... | 2005 | 15982214 |
| experimental induction of bacterial gastritis and gastric ulcer disease in gnotobiotic swine inoculated with porcine helicobacter-like species. | to determine whether 2 isolates of recently isolated swine-origin helicobacter pylori-like bacteria are pathogenic in pigs and compare the signs of gastric disease induced by these isolates with those detected in h pylori- and helicobacter heilmannii-infected pigs. | 2005 | 16008214 |
| gastric helicobacters in domestic animals and nonhuman primates and their significance for human health. | helicobacters other than helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. these very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated "h. heilmannii," but in fact they comprise at least five different helicobacter species, all of which are known to colonize the gastric mucosa of animals. h. suis, which has been isolated from the stomachs of pigs, is the m ... | 2009 | 19366912 |
| role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. part 1: eradication of helicobacter in the cachexia of idiopathic parkinsonism. | neuronal damage in idiopathic parkinsonism may be in response to ubiquitous occult infection. since peptic ulceration is prodromal, helicobacter is a prime candidate. | 2005 | 16104942 |
| helicobacter spp. other than helicobacter pylori. | non-h. pylori helicobacter species (nhphs) are associated with several important human and animal diseases. in the past year research into this group of bacteria has continued to gain attention, and novel species have been described in new niches owing to improvements in detection methods. polymerase chain reaction and/or sequencing remain the gold standard for the detection of this genus. new insights into the pathogenesis of the nhphs in hepatobiliary, gastric, and intestinal diseases were gai ... | 2009 | 19712171 |
| gastroinvasive helicobacter infection in an ocelot (leopardus pardalis). | highly invasive helicobacter-like organisms were found in a 19-year-old female ocelot (leopardus pardalis) with multiple ulcers in the fundic region of the stomach. the bacteria, resembling helicobacter heilmannii, were located largely within canaliculi or in the cytosol of parietal cells. except in the ulcerative lesions, parietal cells were hyperplastic, while chief cells and neck mucous cells were reduced in number. the term "gastroinvasive helicobacter-like organism" was applied. it seems pr ... | 2005 | 16154138 |
| helicobacter pylori and extragastric diseases--other helicobacters. | the involvement of helicobacter pylori in the pathogenesis of extragastric diseases continues to be an interesting topic in the field of helicobacter-related pathology. although conflicting findings have been reported for most of the disorders, a role of h. pylori seems to be important especially for the development of cardiovascular and hematologic disorders. previously isolated human and animal helicobacter sp. flexispira and "helicobacter heilmannii" strains have been validated using polyphas ... | 2005 | 16178972 |
| detection of non-pylori helicobacter species in "helicobacter heilmannii"-infected humans. | a small proportion of patients suffering from chronic active gastritis are diagnosed with gastric helicobacter species other than helicobacter pylori. circumstantial evidence has suggested that these bacteria, also referred to as "helicobacter heilmannii"-like organisms (hhlo), may be transmitted through animals. the isolation of a helicobacter bizzozeronii strain from a human patient confirmed this hypothesis. it was the aim of the present study to assess the presence of animal helicobacter spe ... | 2005 | 16181350 |
| [relation of helicobacter heilmannii to gastric mucosal damage as a model of zoonosis between men and pets]. | | 2005 | 16363610 |
| protective immunization against "candidatus helicobacter suis" with heterologous antigens of h. pylori and h. felis. | "helicobacter (h.) heilmannii" type 1 colonizes the human stomach. it has been shown to be identical to "candidatus h. suis", a helicobacter species colonizing the stomach of more than 60% of slaughter pigs. this bacterium is, until now, not isolated in vitro. the effect of vaccination on "candidatus h. suis" infection was studied in a mouse model. mice were vaccinated intranasally or subcutaneously with whole bacterial cell lysate of helicobacter pylori or helicobacter felis and subsequently ch ... | 2006 | 16423431 |
| the role of ifn-gamma and il-4 in gastric mucosa inflammation associated with helicobacter heilmannii type 1 infection. | although helicobacter heilmannii infection is less common than h. pylori infection in humans, it is considered to be of medical importance because of its association with gastritis, gastric ulcer, carcinoma, and mucosa-associated lymphoid tissue lymphoma of the stomach. however, there have been no studies evaluating the role of the th cell response in h. heilmannii gastric infection. we evaluated the participation of pro-inflammatory and anti-inflammatory cytokines, ifn-gamma and il-4, in h. hei ... | 2006 | 16470313 |
| helicobacter cynogastricus sp. nov., isolated from the canine gastric mucosa. | a gram-negative, microaerophilic helical rod, isolated from the gastric mucosa of a dog and designated strain jkm4(t), was subjected to a polyphasic taxonomic study. the tightly coiled organism, measuring 10-18 mum long and up to 1 mum wide, was motile by means of multiple sheathed flagella located at both ends of the cell and by a periplasmic fibril running along the external side of the helix. strain jkm4(t) grew preferably on biphasic culture plates or on very moist agar. coccoid forms predom ... | 2006 | 16825630 |
| association of helicobacter with cholangiohepatitis in cats. | infection with helicobacter spp. is increasingly linked with hepatobiliary inflammation and neoplasia in people and in a variety of animals. we sought to determine if helicobacter species infection is associated with cholangiohepatitis in cats. deoxyribonucleic acid was extracted from tissue blocks from cats with cholangiohepatitis (32), noninflammatory liver disease (13), and cats with normal liver histology (4). deoxyribonucleic acid was polymerase chain reaction-amplified with 2 sets of helic ... | 2006 | 16955803 |
| helicobacter suis causes severe gastric pathology in mouse and mongolian gerbil models of human gastric disease. | "helicobacter (h.) heilmannii" type 1 is the most prevalent gastric non-h. pylori helicobacter species in humans suffering from gastric disease. it has been shown to be identical to h. suis, a bacterium which is mainly associated with pigs. to obtain better insights into the long-term pathogenesis of infections with this micro-organism, experimental infections were carried out in different rodent models. | 2010 | 21124878 |
| a review of background findings in cynomolgus monkeys (macaca fascicularis) from three different geographical origins. | this review was performed to assess variations in background observations in cynomolgus macaques (macaca fascicularis) originating from three breeding centres located in mauritius, the philippines and vietnam. the data and tissue samples from 90 cynomolgus monkeys (approximately evenly distributed between the three sources) comprising the control groups from 11 regulatory toxicology studies were used for this investigation. clinical data--age, body weight, organ weights, haematology and serum bi ... | 2006 | 16984807 |
| evaluation of "helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogs. | infection with candidatus "helicobacter heilmannii" is associated with gastritis and mucosa-associated lymphoid tissue lymphoma in people. infection with "h. heilmannii" type 1 predominates (80%) and is thought to be acquired from dogs, cats, or pigs. we further examined the zoonotic potential of dogs and cats by amplifying gastric dna from cats (n = 45) and dogs (n = 10) with primers against "h. heilmannii" ureb and 16s rrna genes and sequencing the products. fluorescence in situ hybridization ... | 2004 | 15131182 |
| experimental infection of pigs with 'candidatus helicobacter suis'. | 'candidatus helicobacter suis' is a spiral-shaped bacterium that colonizes the stomach of more than 60% of slaughter pigs. the role of 'candidatus helicobacter suis' in gastric disease of pigs is still unclear. experimental studies in pigs are lacking because this bacterium is unculturable until now. an inoculation protocol using 'candidatus helicobacter suis' infected mouse stomach homogenate was used to reproduce the infection in pigs. control animals were inoculated using negative mouse stoma ... | 2007 | 17216309 |
| non-helicobacter pylori helicobacter species in the human gastric mucosa: a proposal to introduce the terms h. heilmannii sensu lato and sensu stricto. | | 2011 | 21762276 |
| Comparative Genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humans. | ABSTRACT: | 2011 | 22039924 |
| helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with helicobacter pylori-associated gastritis. | the aims of this study were to evaluate the clinicopathologic features of helicobacter heilmannii-associated gastritis and to compare h. heilmannii-associated gastritis with h. pylori-associated gastritis. we reviewed 5,985 consecutive gastric biopsy specimens. all cases of chronic gastritis with helicobacter infection were evaluated with the updated sydney system, and the grades of all gastritis variables were compared between h. heilmannii-associated gastritis and h. pylori-associated gastriti ... | 2007 | 17297253 |
| a report of two children with helicobacter heilmannii gastritis and review of the literature. | an 11-year-old boy with epigastric abdominal pain and a 2 year-old girl with failure to thrive underwent esophagogastroduodenoscopy. endoscopic biopsies from the gastric antrum of both children revealed corkscrew-like spiral bacteria, consistent with the diagnosis of helicobacter heilmannii infection. h. heilmannii is a rare finding in children and is thought to be present in approximately 0.3% of patients undergoing upper endoscopy. clinical presentation, gross and histologic appearance, and tr ... | 2007 | 17929990 |
| gastric helicobacter spp. infection in captive neotropical brazilian feline. | ten captive neotropical brazilian feline were submitted to gastroscopic examination and samples of gastric mucosa from fundus, corpus and pyloric antrum were evaluated for the presence of helicobacter species. warthin-starry (ws) staining and pcr assay with species-specific primers and enzymatic cleavage were applied for bacterial detection and identification. histological lesions were evaluated by haematoxylin and eosin staining. all animals showed normal gross aspect of gastric mucosa. helicob ... | 2011 | 24031634 |
| metabolic versatility of the riftia pachyptila endosymbiont revealed through metagenomics. | the facultative symbiont of riftia pachyptila, named here candidatus endoriftia persephone, has evaded culture to date, but much has been learned regarding this symbiosis over the past three decades since its discovery. the symbiont population metagenome was sequenced in order to gain insight into its physiology. the population genome indicates that the symbionts use a partial calvin-benson cycle for carbon fixation and the reverse tca cycle (an alternative pathway for carbon fixation) that cont ... | 2008 | 18237306 |
| gastric helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis. | gastric helicobacter spp. are associated with chronic inflammation and neoplastic transformation in humans as well as domestic and laboratory species. the present study examined the association of helicobacter heilmannii (hhe) infection in pet cats with feline gastric mucosa associated lymphoid tissue (malt) lymphoma. tissues were collected via gastric biopsy or at necropsy from 47 pet cats with clinical signs of gastrointestinal disease, including vomiting and inappetance, and classified as gas ... | 2008 | 18387674 |
| h. heilmannii infection and gastric carcinogenesis. | | 2008 | 18787286 |
| microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. | there are clinical reports that helicobacter heilmannii, as well as helicobacter pylori, has been clinically reported to cause gastric low-grade mucosa-associated lymphoid tissue-type (malt) lymphoma, although its precise mechanism remains to be clarified. thus, the present study was undertaken to elucidate the alteration of the microcirculatory structure and the relation to angiogenetic factors in mice infected with h. heilmannii for 3 and 6 months. | 2008 | 19120890 |
| protective immunization with homologous and heterologous antigens against helicobacter suis challenge in a mouse model. | helicobacter (h.) suis colonizes the stomach of more than 60% of slaughter pigs and is also of zoonotic importance. recently, this bacterium was isolated in vitro, enabling the use of pure cultures for research purposes. in this study, mice were immunized intranasally or subcutaneously with whole bacterial cell lysate of h. suis or the closely related species h. bizzozeronii and h. cynogastricus, and subsequently challenged with h. suis. control groups consisted of non-immunized and non-challeng ... | 2009 | 19136039 |
| non-helicobacter pylori helicobacters detected in the stomach of humans comprise several naturally occurring helicobacter species in animals. | besides the well-known gastric pathogen helicobacter pylori, other helicobacter species with a spiral morphology have been detected in a minority of human patients who have undergone gastroscopy. the very fastidious nature of these non-helicobacter pylori helicobacters (nhph) makes their in vitro isolation difficult. these organisms have been designated 'helicobacter heilmannii'. however, sequencing of several genes detected in nhph-infected tissues has shown that the 'h. heilmannii' group compr ... | 2009 | 19243435 |
| [gastritis caused by helicobacter heilmannii probably transmitted from dog to child]. | gastric infection with helicobacter heilmannii is rare but is known to be associated with chronic active gastritis, peptic ulcer, and low-grade mucosa-associated lymphoid tissue lymphoma in humans. in contrast to h. pylori, various h. heilmannii species colonize the stomachs of domestic animals, which might be a reservoir for transmission to humans. we report the case of a 12-year-old boy presenting with chronic gastritis caused by h. heilmannii. endoscopic examination reveals h. heilmannii-like ... | 2009 | 19303265 |
| phylogeny of a novel "helicobacter heilmannii" organism from a japanese patient with chronic gastritis based on dna sequence analysis of 16s rrna and urease genes. | "helicobacter heilmannii" is an uncultivable spiral-shaped bacterium inhabiting the human gastric mucosa. it is larger and more tightly-coiled than h. pylori. we encountered a patient with chronic gastritis infected a "h. heilmannii"-like organism (hhlo), designated as sh6. gastric mucosa derived from the patient was orally ingested by specific pathogen free mice. colonization of the mice by sh6 was confirmed by electron microscopy of gastric tissue specimens. in an attempt to characterize sh6, ... | 2009 | 19412605 |
| interaction of vegf to gastric low grade malt lymphoma by helicobacter heilmannii infection in c57/bl/6 mice. | helicobacter heilmannii (hh) has been clinically reported to have some relation to gastric low grade malt lymphoma. recently, we have formed the gastric malt lymphoma in c57bl/6 mice. | 2007 | 19847951 |
| an unusual case of gastric erosions. | | 2009 | 19923347 |
| characterization of multiple helicobacter bizzozeronii isolates from a finnish patient with severe dyspeptic symptoms and chronic active gastritis. | helicobacter pylori is the primary cause of gastritis and peptic ulceration in humans. in a minority of patients with upper gastrointestinal symptoms, long tightly coiled spiral bacteria, provisionally named "helicobacter heilmannii," are observed in gastric biopsies. these bacteria are extremely fastidious and only one previous study has succeeded in obtaining an isolate in vitro. | 2010 | 20302591 |
| gastric infection with kazachstania heterogenica influences the outcome of a helicobacter suis infection in mongolian gerbils. | the mongolian gerbil model is often used to investigate the interactions between different gastric helicobacter species and the gastric tissue. a preliminary screening of a gerbil population intended for use in helicobacter suis infection studies revealed a natural yeast infection in the stomach of these animals. after identification, we have investigated the effect of the gastric yeast infection on the outcome of an experimental h. suis infection in mongolian gerbils. | 2010 | 20302592 |
| suppression of lymphangiogenesis induced by flt-4 antibody in gastric low-grade mucosa-associated lymphoid tissue lymphoma by helicobacter heilmannii infection. | our recent study revealed that per oral infection with helicobacter heilmannii induced low-grade mucosa-associated lymphoid tissue (malt) lymphoma in the gastric fundus of c57bl/6 mice after a period of 6 months, although the pathophysiological mechanism of lymphoma expansion remains to be clarified. the present study was undertaken to elucidate the interaction of this tumor with angiogenesis and lymphangiogenesis. in addition, the effect of flt-4 antibodies on lymphoma expansion was investigate ... | 2010 | 20586849 |
| induction of high endothelial venule-like vessels expressing glcnac6st-1-mediated l-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (madcam-1) in a mouse model of "candidatus helicobacter heilmannii"-induced gastritis and gastric mucosa-associated lymphoid tissue (malt) lymphoma. | "candidatus helicobacter heilmannii" induce chronic gastritis, which eventually leads to gastric b-cell type mucosa-associated lymphoid tissue (malt) lymphoma. this study was performed using an animal model of infection with "candidatus helicobacter heilmannii" to elucidate how this chronic inflammation is induced or maintained. | 2010 | 21073611 |
| helicobacter suis-infected nodular gastritis and a review of diagnostic sensitivity for helicobacter heilmannii-like organisms. | helicobacter heilmannii-like organisms (hhlos) are associated with mucosa-associated lymphoid tissue lymphoma and peptic ulcer. however, the sensitivity of diagnostic tests for hhlos, such as rapid urease test (rut), urea breath test (ubt) and blood antibody, is not high. tightly coiled spiral microorganisms were found in the gastric mucosal biopsy specimen of a 48-year-old asymptomatic woman. her findings were positive for rut and ubt, but negative for blood antibody and stool antigen against h ... | 2017 | 26120299 |
| the first description of gastric helicobacter in free-ranging wild boar (sus scrofa) from poland. | specimens of gastric mucosa of 17 free-ranging wild boars (sus scrofa) shot in the central poland during 2007/2008 hunting season were investigated for the presence of helicobacter species. histopathology, helicobacter genus-specific 16s rrna pcr, and dna sequence analysis were employed. in pcr analysis the presence of helicobacter's dna was detected in one stomach. obtained sequence analysis showed its relatedness to helicobacter heilmannii type 2. in histopathology of the pcr-positive sample t ... | 2010 | 21077447 |
| reproduction of severe gastroesophageal ulcers (geu) in gnotobiotic swine infected with porcine helicobacter pylori-like bacteria. | groups of gnotobiotic piglets were orally inoculated at 3 days of age with either helicobacter heilmannii (hh) or a newly described porcine-origin gastric helicobacter pylori (hp)-like bacterium. three hh-infected and 6 porcine hp-like-infected swine were fed a milk replacement diet containing 5-10% (v/v) sterile corn syrup as a dietary source of fermentable carbohydrate. none of the piglets infected with hh and supplemented with corn syrup developed gastric mucosal ulcers; 2 developed small ero ... | 2006 | 17099152 |
| "candidatus helicobacter heilmannii" from a cynomolgus monkey induces gastric mucosa-associated lymphoid tissue lymphomas in c57bl/6 mice. | both helicobacter pylori and "candidatus helicobacter heilmannii" infections are associated with peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (malt) lymphomas. however, good animal models of h. pylori clinical diseases are rare. in this study, we aimed to establish an animal model of "candidatus helicobacter heilmannii" gastric malt lymphoma. we used a urease-positive gastric mucosal and mucus homogenate from a cynomolgus monkey maintained in c57bl/6 mouse ... | 2007 | 17194807 |
| peptic ulcer disease associated with helicobacter felis in a dog owner. | the aim of this study was to investigate the identity of the helicobacter heilmannii-like bacteria found in the stomach of a human patient suffering from stomach ulcers and her asymptomatic pet dog. an elderly woman was referred for gastroscopy because of right hypochondrial pain, nausea, anorexia and vomiting. gastric ulcers were observed and histology revealed the presence of multiple h. heilmannii-like bacteria. multiplex polymerase chain reaction (pcr) identified the bacteria as h. felis. he ... | 2007 | 17206081 |
| neonatal fc receptor for igg (fcrn) expressed in the gastric epithelium regulates bacterial infection in mice. | neonatal fc receptors for immunoglobulin (ig)g (fcrn) assume a central role in regulating host igg levels and igg transport across polarized epithelial barriers. we have attempted to elucidate the contribution of fcrn in controlling helicobacter infection in the stomach. c57bl/6j wild-type or fcrn(-/-) mice were infected with helicobacter heilmannii, and gastric lesions, bacterial load and the levels of antigen-specific igg in serum and gastric juice were analyzed. the elevated levels of anti-h. ... | 2012 | 22089027 |
| evaluation of the helicobacteraceae in the oral cavity of dogs. | to determine the helicobacter spp present in the oral cavity of dogs and the relationship of those organisms with gastric helicobacter spp to better define the potential for dog-human and dog-dog transmission. | 2011 | 22023125 |