| annona muricata leaves accelerate wound healing in rats via involvement of hsp70 and antioxidant defence. | annona muricata, a member of the annonaceae family, is commonly known as soursop and graviola. the leaves of this tropical fruit tree are widely used in folk medicine against skin diseases and abscesses, however there is no scientific evidence justifying the use of a. muricata leaves. the aim of the present study is to evaluate the wound healing potential of ethyl acetate extract of a. muricata leaves (eeam) towards excisional wound models in rats. | 2015 | 25899210 |
| graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. | pancreatic tumors are resistant to conventional chemotherapies. the present study was aimed at evaluating the potential of a novel plant-derived product as a therapeutic agent for pancreatic cancer (pc). the effects of an extract from the tropical tree annona muricata, commonly known as graviola, was evaluated for cytotoxicity, cell metabolism, cancer-associated protein/gene expression, tumorigenicity, and metastatic properties of pc cells. our experiments revealed that graviola induced necrosis ... | 2012 | 22475682 |
| annonamine, a new aporphine alkaloid from the leaves of annona muricata. | atypical parkinsonism in the caribbean island guadeloupe is thought to be associated with the consumption of plants of the annonaceae family, especially annona muricata (soursop). in this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of a. muricata l. together with four known benzylisoquinoline alkaloids (2-5). the structures of the isolated compounds were elucidated by the spectroscopic method. | 2012 | 22293487 |
| nigerian foodstuffs with prostate cancer chemopreventive polyphenols. | dietary polyphenols are antioxidants that can scavenge biological free radicals, and chemoprevent diseases with biological oxidation as their main etiological factor. in this paper, we review our laboratory data vis-ὰ-vis available literature on prostate cancer chemopreventive substances in nigerian foodstuffs. dacryodes edulis fruit, moringa oleifera and syzygium aromaticum contained prostate active polyphenols like ellagic acid, gallate, methylgallate, catechol, kaempferol quercetin and their ... | 2011 | 21992488 |
| three new megastigmanes from the leaves of annona muricata. | three new megastigmanes (1-3), named annoionols a and b (1, 2) and annoionoside (3), were isolated from the leaves of annona muricata l. (annonaceae) together with 14 known compounds (4-17). among the known compounds, annoionol c (4) was isolated from a natural source for the first time. the structures of all compounds were elucidated by spectroscopic and chemical analyses. | 2012 | 21892756 |
| [chemical constituents of an endophytic fungus from annona muricata]. | to investigate the chemical constituents of an endophytic fungus, f-31, from annona muricata and search antitumor natural products. | 2010 | 21355237 |
| comprehensive characterization of annonaceous acetogenins within a complex extract by hplc-esi-ltq-orbitrap® using post-column lithium infusion. | annonaceous acetogenins (aags) are a homogenous class of polyketides proposed as environmental neurotoxins. previous dereplication studies of aags were limited by the use of low-resolution mass spectrometers. only poor information in terms of structures was provided due to the limited fragmentation of protonated or sodium cationized species. an innovative approach, using reversed-phase high-performance liquid chromatography coupled to a hybrid linear ion trap/orbitrap mass spectrometer (ltq-orbi ... | 2012 | 23147829 |
| study on the volatile oil contents of annona glabra l., annona squamosa l., annona muricata l. and annona reticulata l., from vietnam. | the volatile compounds identified from four species of annona from vietnam are being reported. the oils were obtained from aliquots of plant samples by steam distillation and subjected to gc and gc-ms analysis. the main compounds of annona glabra l., were β-caryophyllene (21.5%) germacrene d (17.7%), α-cadinol (5.4%) and β-elemene (5.2%). annona squamosa l., comprised mainly of α-pinene (1.0-11.9%), limonene (0.8-11.7%), β-cubebene (0.5-13.0%), β-caryophyllene (11.6-24.5%), spathulenol (0.8-9.0% ... | 2013 | 22989376 |
| possible mechanisms of action of the hypotensive effect of annona muricata (soursop) in normotensive sprague-dawley rats. | annona muricata linn (annonaceae) (soursop) is a food plant reported to have antihypertensive properties. | 2012 | 22950673 |
| chemopreventive potential of annona muricata l leaves on chemically-induced skin papillomagenesis in mice. | annona muricata l (annonaceae), commonly known as soursop has a long, rich history in herbal medicine with a lengthy recorded indigenous use. it had also been found to be a promising new anti-tumor agent in numerous in vitro studies. the present investigation concerns chemopreventive effects in a two-stage model of skin papillomagenesis. chemopreventive effects of an ethanolic extract of a. muricata leaves (amle) was evaluated in 6-7 week old icr mice given a single topical application of 7,12-d ... | 2012 | 22938417 |
| antinociceptive and anti-inflammatory activities of the ethanol extract of annona muricata l. leaves in animal models. | antinociceptive and anti-inflammatory activities of the ethanol extract from annona muricata l. leaves were investigated in animal models. the extract delivered per oral route (p.o.) reduced the number of abdominal contortions by 14.42% (at a dose of 200 mg/kg) and 41.41% (400 mg/kg). doses of 200 and 400 mg/kg (p.o) inhibited both phases of the time paw licking: first phase (23.67% and 45.02%) and the second phase (30.09% and 50.02%), respectively. the extract (p.o.) increased the reaction time ... | 2010 | 20559502 |
| apolar annonaceous acetogenins from the fruit pulp of annona muricata. | a methylene chloride extract of the pulp of annona muricata l. was fractionated in search for scarcely functionalized annonaceous acetogenins (type e). previously known c-35 and c-37 mono-epoxy unsaturated compounds, epomuricenins-a and -b (1+2) and epomusenins-a and -b (3+4), were obtained. two new mono-epoxy saturated c-35 representatives, epomurinins-a and -b (5+6) were also isolated. | 2009 | 19924072 |
| a flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of annona muricata linn. | chemical investigation on leaves of annona muricata resulted in the isolation of the flavonol triglycoside, quercetin 3-o-α-rhamnosyl-(1″″ → 6″)-β-sophoroside, together with twelve known phenolics. the structures of these compounds were established by 1d- and 2d-nuclear magnetic resonance spectroscopic techniques and mass spectrometry data. the in vitro antioxidant studies of the investigated aqueous ethanol extract and its column fractions were accomplished using the oxygen radical absorbance c ... | 2012 | 22644843 |
| distinctive exotic flavor and aroma compounds of some exotic tropical fruits and berries: a review. | the characteristic flavor of exotic tropical fruits is one of their most attractive attributes to consumers. in this article, the enormous diversity of exotic fruit flavors is reviewed. classifying some of the exotic fruits into two classes on the basis of whether esters or terpenes predominate in the aroma was also attempted. indeed, as far as exotic tropical fruits are concerned, the majority of fruits have terpenes predominating in their aroma profile. some of the fruits in this group are the ... | 2012 | 22591343 |
| quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of annona muricata linn. in normal and immortalized human cell lines. | natural products have been the target for cancer therapy for several years but there is still a dearth of information on potent compounds that may protect normal cells and selectively destroy cancerous cells. the present study was aimed to evaluate the cytotoxic potential of n-butanolic leaf extract of annona muricata l. on wrl-68 (normal human hepatic cells), mda-mb-435s (human breast carcinoma cells) and hacat (human immortalized keratinocyte cells) lines by xtt assay. prior to cytotoxicity te ... | 2012 | 22524847 |
| host range and distribution of fruit-infesting pestiferous fruit flies (diptera, tephritidae) in selected areas of central tanzania. | the host range of major fruit fly pests in central tanzania was evaluated from october 2004 to october 2006. samples of 48 potential hosts were collected and incubated for fruit fly emergence. bactrocera invadens was the dominant species in incidence expressed as the ratio of infested to total number samples collected, as well as infestation rate, expressed as number of flies emerging per unit weight. eight new host fruits are reported. infestation by native pests, such as ceratitis capitata and ... | 2009 | 19323850 |
| tropical american plants in the treatment of infectious diseases. | the increasingly diverse u.s. immigrant populations and the growing use of medicinal herbs create a need for health care professionals to expand their knowledge in this area. this is a review of tropical plants, annona muricata, artemisia absinthium, cinchona officinalis, illicium verum, momordica charantia, opuntia streptacantha, schinus terebinthifolius, and tabebuia avellanedae (impetiginosa), commonly used by latino and haitian populations for the treatment of infectious disease. all the eig ... | 2008 | 22436096 |
| acetogenins in annona muricata l. (annonaceae) leaves are potent molluscicides. | an ethanolic extract of the leaves of annona muricata was shown to be toxic to adult forms of the snail biomphalaria glabrata (lc50 9.32 microg ml(-1)) and to larvae of the brine shrimp artemia salina (lc50 0.49 microg ml(-1)). activity-guided fractionation of the extract gave rise to a sample with high molluscicidal activity that contained the acetogenins, annonacin (90%), isoannonacin (6%) and goniothalamicin (4%). | 2006 | 16401556 |
| the chemopotential effect of annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin e in ht-29 cells: a bioassay-guided approach. | annona muricata has been used in folk medicine for the treatment of cancer and tumors. this study evaluated the chemopreventive properties of an ethyl acetate extract of a. muricata leaves (eeaml) on azoxymethane-induced colonic aberrant crypt foci (acf) in rats. moreover, the cytotoxic compound of eeaml (annomuricin e) was isolated, and its apoptosis-inducing effect was investigated against ht-29 colon cancer cell line using a bioassay-guided approach. this experiment was performed on five grou ... | 2015 | 25860620 |
| antioxidant, dna protective efficacy and hplc analysis of annona muricata (soursop) extracts. | annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. in india, it has a long history of traditional use in treating various ailments. the present investigation was carried out to characterize the phytochemicals present in the methanolic and aqueous leaf extracts of a. muricata, followed by validation of its radical scavenging and dna protection activities. the extracts were also analyzed for its total phenolic contents and subjected to hplc analysis to ... | 2015 | 25829616 |
| antiproliferative activity and induction of apoptosis by annona muricata (annonaceae) extract on human cancer cells. | annona muricata (a. muricata) is widely distributed in asia, africa and south america. different parts of this plant are used to treat several diseases in cameroon. the aim of this study is to determine the in vitro anti-proliferative effects and apoptotic events of a. muricata extracts on hl-60 cells as well as to quantify its phenols content. | 2014 | 25539720 |
| antiproliferative activity of aqueous leaf extract of annona muricata l. on the prostate, bph-1 cells, and some target genes. | annona muricata l. has been reported to possess antitumor and antiproliferative properties. not much work has been done on its effect on bph-1 cell lines, and no in vivo studies targeting the prostate organ exist. the study determined the effect of a muricata on human bph-1 cells and prostate organ. | 2015 | 25411208 |
| gastroprotective activity of annona muricata leaves against ethanol-induced gastric injury in rats via hsp70/bax involvement. | the popular fruit tree of annona muricata l. (annonaceae), known as soursop and graviola, is a widely distributed plant in central and south america and tropical countries. leaves of a. muricata have been reported to possess antioxidant and anti-inflammatory activities. in this study, the gastroprotective effects of ethyl acetate extract of a. muricata leaves (eeam) were investigated against ethanol-induced gastric injury models in rats. the acute toxicity test of eeam in rats, carried out in tw ... | 2014 | 25378912 |
| phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of annona muricata (graviola). | to determine the phytochemical composition, antioxidant and anticancer activities of ethanolic and water leaves extracts of annona muricata (a. muricata) from the eastern uganda. | 2014 | 25312150 |
| annona muricata leaves induce g₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human hct-116 and ht-29 colon cancer cells. | annona muricata known as "the cancer killer" has been widely used in the traditional medicine for the treatment of cancer and tumors. the purpose of this study is to investigate the anticancer properties of ethyl acetate extract of annona muricata leaves (eeam) on ht-29 and hct-116 colon cancer cells and the underlying mechanisms. | 2014 | 25195082 |
| mechanisms of analgesic and anti-inflammatory properties of annona muricata linn. (annonaceae) fruit extract in rodents. | unripe fruit of annona muricata linn. (annonaceae) (soursop) is used in traditional african medicine for the treatment of neuralgia, rheumatism, and arthritic pain. this study sought to investigate the analgesic and anti-inflammatory effects of lyophilized fruit extract of annona muricata (am) in rodents. the analgesic activity was evaluated using the mouse writhing, formalin, and hot-plate tests while the anti-inflammatory action was investigated using the carrageenan-induced rat paw edema and ... | 2014 | 25133801 |
| annona muricata leaves induced apoptosis in a549 cells through mitochondrial-mediated pathway and involvement of nf-κb. | annona muricata leaves have been reported to have antiproliferative effects against various cancer cell lines. however, the detailed mechanism has yet to be defined. the current study was designed to evaluate the molecular mechanisms of a. muricata leaves ethyl acetate extract (ameae) against lung cancer a549 cells. | 2014 | 25127718 |
| an annotated checklist of scale insects (hemiptera: coccoidea) of saint lucia, lesser antilles . | an annotated list of 83 scale insect species (hemiptera: sterorrhyncha: coccoidea) recorded from saint lucia is presented, based on data gathered from uk quarantine interceptions, samples collected in an urban coastal habitat in the north west of the island in 2013, and published records. thirty-three species (40%) are recorded for the first time for the country, including dysmicoccus joannesiae (costa lima), a south american mealybug, and poliaspoides formosana (takahashi), an asian armoured sc ... | 2014 | 25112239 |
| effects of propylene glycol alginate and sucrose esters on the physicochemical properties of modified starch-stabilized beverage emulsions. | this study was conducted to investigate the effect of main emulsion components namely, modified starch, propylene glycol alginate (pga), sucrose laurate and sucrose stearate on creaming index, cloudiness, average droplet size and conductivity of soursop beverage emulsions. generally, the use of different emulsifiers or a mixture of emulsifiers has a significant (p < 0.05) effect on the response variables studied. the addition of pga had a significant (p < 0.05) effect on the creaming index at 55 ... | 2014 | 24962400 |
| effect of the application of 1-methylcyclopropene and wax emulsions on proximate analysis and some antioxidants of soursop (annona muricata l.). | the effect of the application of 1-methylcyclopropene (1-mcp) and wax emulsions, alone or combined, on composition analysis, vitamin c, polyphenols, and antioxidant capacity of soursop was evaluated. fruits were stored as follows: at 25 °c (control), and at 16 °c: fruits sprayed with candelilla or flava emulsions, fruits treated with 1500 nl/l of 1-mcp (20 °c, 12 h), and fruits treated with 1-mcp and then sprayed with emulsions. fruits were allowed to ripen and the edible part was used for analy ... | 2014 | 24892105 |
| three new anti-proliferative annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (annona muricata). | bioassay-guided fractionation of the fruit powder of graviola (annona muricata) yielded three novel compounds: muricins j, k, and l. the compounds are all c35 annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and hplc purification. these three acetogenins demonstrated an antiproliferative against human prostate cancer pc-3 cells. | 2014 | 24780120 |
| the effect of prime emulsion components as a function of equilibrium headspace concentration of soursop flavor compounds. | perceptions of food products start when flavor compounds are released from foods, transported and appropriate senses in the oral and nose are triggered. however, the long-term stability of flavor compounds in food product has been a major concern in the food industry due to the complex interactions between key food ingredients (e.g., polysaccharides and proteins). hence, this study was conducted to formulate emulsion-based beverage using natural food emulsifiers and to understand the interaction ... | 2014 | 24708894 |
| influence of annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats. | to evaluate the effect of hydroalcoholic extract of a. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (dmsa), both labeled with 99mtechnetium. | 2014 | 24626725 |
| evaluation of artificial diets for attacus atlas (lepidoptera: saturniidae) in yogyakarta special region, indonesia. | the objective of this research was to evaluate artificial diets that can be used to successfully culture the atlas silk moth, attacus atlas l. (lepidoptera: saturniidae) indoors. four plant species were evaluated as the basic component of each diet, barringtonia (barringtonia asiatica), cheesewood (nauclea orientalis), soursop (annona muricata), and mahogany (swietenia mahagoni). evaluation of the nutritional value of each diet was determined by an analysis of the hemolymph proteins of sixth ins ... | 2013 | 24498735 |
| toxicological evaluation of the lyophilized fruit juice extract of annona muricata linn. (annonaceae) in rodents. | abstract background: annona muricata linn. (annonaceae) (am) fruit juice is widely consumed either raw or after processing in tropical countries because of its very juicy, creamy and sweet character including its medicinal importance. the safety of am fruit was investigated in sprague-dawley rats for acute and 60-day subchronic toxicity effects. methods: rats were administered distilled water (dw) and am daily at doses of 80, 400 and 2000 mg/kg orally for 60 days. at the end of the study, blood ... | 2013 | 24353141 |
| [biology and behavior of the seed borer wasp bephratelloides cubensis ashmead (hymenoptera: eurytomidae)]. | the soursop annona muricata is an important fruit for national market, and for exportation, but the crop is affected by pests and diseases. the seed borer wasp bephratelloides cubensis ashmead is the pest that produces the highest damage to the crop in mexico. sixty percent of damaged fruits and 5-50 seeds per fruit have been registered, with 25% reduction in yield. in nayarit, mexico, 100% of damaged fruits were recorded. in this state, an experiment with soursop was conducted to study the life ... | 2010 | 20877987 |
| total synthesis of cis-reticulatacin-10-ones a and b: absolute stereochemical assignment. | cis-reticulatacin-10-ones a and b were synthesised as a predefined mixture of diastereoisomers (dr ∼ 1 : 9) in nine steps from the acid chloride 8, and without the use of hydroxyl protecting groups. comparison of the chiral hplc chromatogram of the synthetic sample with that of the natural product isolated from the roots of the tropical fruit tree annona muricata l. showed the natural product to be a mixture of a and b diastereoisomers (dr ∼ 1 : 1). | 2010 | 20733975 |
| [biology of tetranychus mexicanus (mcgregor) (acari: tetranychidae) on three species of annonaceae]. | the mite tetranychus mexicanus (mcgregor) is considered a pest of a variety of plant species in the americas. although this mite apparently causes economic damage to annonaceae, little is known about its biology. here we studied the biology of t. mexicanus on soursop (annona muricata), sweetsop (annona squamosa) and araticum (annona coriaceae). the first two species are the most important economical annonaceae species in northeast brazil; araticum is commonly found in the region, but not commerc ... | 2010 | 20676502 |
| enhanced extraction yields and mobile phase separations by solvent mixtures for the analysis of metabolites in annona muricata l. leaves. | the effects of five extraction solvents and their mixtures on the yield of metabolites in crude and fractionated extracts of annona muricata l. leaves were investigated by direct comparison. extraction media were prepared using simplex centroid mixtures of ethanol, ethyl acetate, dichloromethane, acetone, and chloroform. the effects of the mobile phase solvent strength and the analysis wavelength on the chromatographic separation were also investigated. solvent mixtures rather than pure solvents ... | 2009 | 19882621 |
| total synthesis and stereochemical assignment of cis-uvariamicin i and cis-reticulatacin. | diastereoisomeric mixtures of cis-uvariamicin i (15r,16r,19s,20s,36s and 15s,16s,19r,20r,36s) and cis-reticulatacin (17r,18r,21s,22s,36s and 17s,18s,21r,22r,36s) were synthesized to determine the stereochemistry of the natural products isolated from annona muricata. it was not possible to resolve a mixture of the four synthetic isomers using chiral hplc, but the mixed isomers could be distinguished using chiral hplc eims with extracted fragment ion analysis. comparison of synthetic standards wit ... | 2009 | 19673468 |
| a new species of crypticerya cockerell (hemiptera: monophlebidae) from colombia, with a key to species of the tribe iceryini found in south america. | the adult female and first-instar nymph of a new species of iceryine scale insect, crypticerya multicicatrices kondo & unruh sp. n., are described and illustrated. the new scale insect is polyphagous and was collected on 13 plant species distributed in seven botanical families, including fruit trees of economic importance such as mango and soursop. a taxonomic key to the species of the tribe iceryini known from south america is provided. previous records of c. brasiliensis (hempel) from colombia ... | 2009 | 19347101 |
| antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern brazil. | the objective of this study was to evaluate antiproliferative activity, antioxidant capacity and tannin content in plants from semi-arid northeastern brazil (caatinga). for this study, we selected 14 species and we assayed the methanol extracts for antiproliferative activity against the hep-2 (laryngeal cancer) and nci-h292 (lung cancer) cell lines using the (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazole) (mtt) method. in addition, the antioxidant activity was evaluated with the dpph (2,2-d ... | 2010 | 21107308 |
| flooding, root temperature, physiology and growth of two annona species. | the effects of root zone temperature (rzt) and flooding on physiology and growth of annona glabra l. (pond apple) and a. muricata l. (soursop) were investigated. trees planted in containers were exposed to rzts of 5, 10, 20, 25 or 35 degrees c in controlled root temperature chambers. trees at each rzt were either non-flooded (control) or continuously flooded. there were four replications over time for each treatment combination. pond apple was more flood-tolerant than soursop. a combination of f ... | 2004 | 15234899 |
| detection and determination of reticuline and n-methylcoculaurine in the annonaceae family using liquid chromatography-tandem mass spectrometry. | in guadeloupe, the french west indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the annonaceae family. local inhabitants consume the fruits, and also drink tea made from the leaves. in the present study, we used liquid chromatography-tandem mass spectrometry (lc/ms/ms) with multiple reaction monitoring (mrm) to detect low-molecular-weight neurotoxic benzylisoquinoline deri ... | 2004 | 15149614 |
| flow-injection amperometric determination of dopamine in pharmaceuticals using a polyphenol oxidase biosensor obtained from soursop pulp. | the amperometric determination of dopamine (do) in pharmaceuticals formulations by flow injection analysis (fia) is proposed. an enzymatically modified carbon paste electrode constituted by 25% (w/w) of polyphenol oxidase obtained from annona muricata l. tissue, 30% (w/w) of graphite, 30% (w/w) of silicone and 15% (w/w) of 7,7,8,8 tetracyanoquinodimethane (tcnq), was used as flow-through detector. the flow amperometric detection was carried out at a potential of 0.10 v (vs. ag/agcl) when an inje ... | 2003 | 14656593 |
| proximate composition and selected physicochemical properties of the seed, pulp and oil of sour sop (annona muricata). | proximate composition and physicochemical analyses were carried out on the seed, pulp and extracted oil of sour sop (annona muricata). the results showed that the seed contained 8.5% moisture, 2.4% crude protein, 13.6% ash, 8.0% crude fiber, 20.5% fat and 47.0% carbohydrate. the seed also contained 0.2% water soluble ash, 0.79% titratable acidity and 17.0 mg calcium/100 g. the pulp was found to contain 81% moisture, 3.43% titratable acidity and 24.5% non-reducing sugar. selected physicochemical ... | 2002 | 12049148 |
| annonaceous acetogenins of the seeds from annona muricata. | muricatenol (1) is a new c37 non-thf ring acetogenin with four hydroxyls and one isolated double bond in the long aliphatic chain. 2,4-cis-gigantetrocinone (2) and 2,4-trans-gigantetrocinone (3) have been isolated as their acetates by preparative tlc. 2,4-trans-isoannonacin-10-one (4) and 2,4-trans-isoannonacin (5) have been isolated as only 2,4-trans-form for the first time (no cis-form). also four known acetogenins, gigantetrocin-a (6), gigantetrocin-b (7), annomontacin (8), gigantetronenin (9 ... | 2001 | 11783580 |
| murihexol, a linear acetogenin from annona muricata. | murihexol (1), a novel acetogenin, and three known ones, donhexocin (2), annonacin a and annonacin, have been isolated from the seeds of annona muricata. compound 1 is a c(35) acetogenin without any thf rings, with six hydroxyls in the long aliphatic chain. the hydroxyls of 1 and 2 are all located at c-4, c-10, c-15, c-16, c-19 and c-20, but their stereochemistries are different. the vicinal diol at c-15/c-16 in 1 is threo and c-19/c-20 has the erythro configuration; in 2 c-15/c-16 and c-19/c-20 ... | 1998 | 11711082 |
| coronin from roots of annona muricata, a putative intermediate in acetogenin biosynthesis (1). | a novel acetogenin, coronin, was isolated from the roots of annona muricata l. the structure was elucidated by a combination of chemical and spectral methods including ms and nmr measurements. coronin is probably an intermediate in the biosynthetic pathway of bis-tetrahydrofuran acetogenins, and is proposed as a biogenetic precursor of neoannonin-b. | 2001 | 11509986 |
| cohibins c and d, two important metabolites in the biogenesis of acetogenins from annona muricata and annona nutans. | two new annonaceous acetogenins, cohibins c (1a) and d (1b), have been isolated by extensive chromatography of a hexane extract of annona muricata seeds and a cyclohexane extract of annona nutans root bark. their structures have been established on the basis of spectral evidence (nmr, ms) and confirmed by chemical transformation into a pair of monotetrahydrofuran (mono-thf) acetogenins. the role of these compounds in the biogenesis of mono-thf acetogenins is discussed. | 2000 | 11000017 |
| use of soursop and sweetsop juice in the management of diarrhoea in children. | | 1998 | 10453123 |
| hepatoprotective activity of annona muricata linn. and polyalthia cerasoides bedd. | the hepatoprotective effect of annona muricata and polyalthia cerasoides (annonaceae) were monitored by estimating the serum transaminases (sgot and sgpt), serum alkaline phosphatase (salp), liver and brain lipid peroxidation (lop) and their total protein content. both drugs at a dose of 100 μg/kg significantly prevented the increase in serum transaminases, salp, liver and brain lop and decrease in liver and brain total protein content following carbontetrachloride (ccl) induced hepatoxicity in ... | 1999 | 22556909 |
| cis-monotetrahydrofuran acetogenins from the roots of annona muricata1 | phytochemical investigation of roots of annona muricata led to the identification of seven mono-tetrahydrofuran (mono-thf) acetogenins. six new acetogenins having the unusual cis-configuration of the thf ring, cis-solamin (1), cis-panatellin (2), cis-uvariamicin iv (3), cis-uvariamicin i (4), cis-reticulatacin (5), and cis-reticulatacin-10-one (6) were identified, in addition to a known compound, solamin. | 1998 | 9599252 |
| screening of medicinal plants from suriname for 5-ht(1a) ligands: bioactive isoquinoline alkaloids from the fruit of annona muricata. | plants from suriname (south-america) and several annona species, including a. muricata, a. ckerimolia, a. montana and a. glabra were screened for 5-ht(1a) receptor binding activity by ligand-binding-studies (lbs). crude extracts of all annona species and from hibiscus bifurcatus, irlbarchia purpurascens and scoparia dulcis showed high activity. the isoquinoline alkaloids asimilobine (1), nornuciferine (2), and annonaine (3) were isolated as the active principles from the fruit of annona muricata ... | 1997 | 23195401 |
| [studies on the chemical constituents of annona muricata]. | annonaceous acetogenin (or polyketide) is a kind of potential antineoplastic agents from annonaceae plants. two new acetogenins, muricatalicin (i) and muricatalin (vi), a mesitoate of a new acetogenin, annonacin-b mesitoate (vb), and three known acetogenins, annonacin (ii), annonacin-a (iii) and annonacin-10-one (iv) have been isolated from annona muricata l. the structures and relative stereochemistry of i, vi and vb were elucidated on the basis of spectral analysis and examination of their ace ... | 1997 | 11596323 |
| antiparasitic activity of annona muricata and annona cherimolia seeds. | methanolic extracts of annona muricata and a. cherimolia (annonaceae) seeds were tested for antiparasitic activity against e. histolytica, n. brasiliensis, m. dessetae and a. salina. the acetogenins isolated from these extracts are found to be responsible for the important activity on infective larvae of molinema desetae. | 1991 | 1798795 |
| use of medicinal plants by ambulatory patients in puerto rico. | the use of medicinal plants by the patients at the outpatient clinics of five health-care centers in puerto rico was evaluated. medication histories were obtained for 802 patients ranging in age from two months to 91 years. the most frequent medical diagnosis was cardiovascular disease (54% of the patients). respiratory and digestive disorders were the least frequent conditions, identified in only 9% and 6% of the cases, respectively. medicinal plants were used by 57% of the population. patients ... | 1984 | 6496496 |
| two new cytotoxic monotetrahydrofuran annonaceous acetogenins, annomuricins a and b, from the leaves of annona muricata. | the leaves of annona muricata have yielded eight monotetrahydrofuran annonaceous acetogenins. two of them, annomuricins a [1] and b [2], whose chemical structures were deduced by ms, nmr, ir, and uv spectral and chemical methods, are novel and unusual. compounds 1 and 2 each possess five hydroxyl groups; two hydroxyl groups are vicinal, with the vicinal group of 1 threo and that of 2 erythro. the absolute configurations of 1 and 2 were determined by mosher ester methodology. six monotetrahydrofu ... | 1995 | 7673926 |
| bioactive single-ring acetogenins from seed extracts of annona muricata. | | 1993 | 8441787 |
| respiration during postharvest development of soursop fruit, annona muricata l. | fruit of soursop, annona muricata l., showed increased co(2) production 2 days after harvest, preceding the respiratory increase that coincided with autocatalytic ethylene evolution and other ripening phenomena. experiments to alter gas exchange patterns of postharvest fruit parts and tissue cylinders had little success.the respiratory quotient of tissue discs was near unity throughout development. 2,4-dinitrophenol uncoupled respiration more effectively than carbonylcyanide m-chlorophenylhydraz ... | 1984 | 16663783 |
| [alkaloids of annonaceae. xxix. alkaloids of annona muricata]. | from leaves, root - and stem - barks of annona muricata l., seven isoquinoline alkaloids have been isolated: reticuline (main alkaloid), coclaurine, coreximine, atherosperminine, stepharine. anomurine and anomuricine, two minor alkaloids, are new tetrahydrobenzylisoquinolines, with 5, 6, 7 substituted ring a. the phytochemical significance of these alkaloids is discussed. | 1981 | 17401878 |
| otubreak of food poisoning at the school of medicine cafeteria traced to guanabana seed (soursop seed). | | 1958 | 13560599 |
| [soursop food, platydoras costatus (linnaeus) from the lagoon of nazareth, piaua (actinopterygii, doradidae)]. | | 1948 | 18891735 |
| use of medicinal plants for diabetes in trinidad and tobago. | use of herbal remedies from medicinal plants (bush medicines) was studied in 622 people with diabetes mellitus attending 17 government health centers on the island of trinidad, trinidad and tobago. bush medicines were used by 42% of patients surveyed and were used for diabetes by 24%. bush medicine use was more frequent in afro-trinidadians and in those of mixed ethnicity than in indo-trinidadians, and was also more prevalent in those with lower educational attainment. most patients using bush m ... | 1997 | 9128111 |
| isolation of montecristin, a key metabolite in biogenesis of acetogenins from annona muricata and its structure elucidation by using tandem mass spectrometry. | during the course of our continuing search for acetogenins from annonaceae, a new metabolite, montecristin, possibly involved in the biogenesis of acetogenins, was isolated from the roots of annona muricata. its structure was elucidated on the basis of uv, ir, (1)h and (13)c nmr, and mass spectrometry. the identification of the main stuctural features of montecristin (1) was obtained from the nmr spectra whereas their locations on the alkyl chain were evidenced by using mass spectrometry. the at ... | 1997 | 11671442 |
| five new monotetrahydrofuran ring acetogenins from the leaves of annona muricata. | bioactivity-directed fractionation of the leaves of annona muricata resulted in the isolation of annopentocins a (1), b (2), and c(3), and cis- and trans-annomuricin-d-ones (4, 5). compounds 1-3 are the first acetogenins reported bearing a mono-tetrahydrofuran (thf) ring with one flanking hydroxyl, on the hydrocarbon side, and another hydroxyl, on the lactone side, that is one carbon away from the thf ring. compounds 4 and 5 were obtained in a mixture and are new mono-thf ring acetogenins bearin ... | 1996 | 8946744 |