| n-acetylbenzotriazole as a protein reagent. specific behaviour towards delta-chymotrypsin. | when n-14c acetylbenzotriazole, presented here as a new agent for the acetylation of proteins, reacted at ph 8 and 25 degrees c with delta-chymotrypsin, 15 amino groups (the epsilon-amino groups of lysing residues and the alpha-amino terminus of half-cystine-1) and two phenolic groups (those of the two exposed tyrosine residues) were acetylated with respective pseudo first-order constants of 0.056 +/- 0.003 and 0.15 +/- 0.03 min(-1). surprisingly, in contrast with the acetic anhydride reaction, ... | 1976 | 6280 |
| studies on the centrally mediated hypotensive activity of guanabenz. | prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. potential mechanisms responsible for the reduction of efferent sympathetic activity were examined in the present series. guanabenz failed to modify carotid sinus nerve activity in a perfused sinus preparation. it reduced sympathetic outflow, heart rate and blood pressure in debuffered cats indicating that its actions are not mediated primar ... | 1976 | 6290 |
| effect of noninhalant anesthetics on the conduction of excitation in the ventrolateral columns of the cat spinal cord. | acute tests on spinal cats were set up to enquire into the effect produced by sodium oxybutyrate, hexobarbital sodium and viadril used in anesthetic doses on the evoked responses in the ventrolateral columns of the spinal cord following stimulation of the skin and pelvic nerves with single and paired stimuli at an interval of 100 msec. sodium oxybutyrate forces the amplitude of both the evoked responses after the paired stimulation below the initial level by 40-70 per cent. hexobarbital sodium a ... | 1975 | 6304 |
| effect of analgestics and narcotics on the potentials of the posterior roots evoked by stimulation of the sensorimotor cortex. | experiments set up on unanesthetized, curarized cats demonstrated that sodium oxybutyrate in doses of 75--200 mg/kg and nembutal in doses of 5--20 mg/kg prolong the duration of corticospinal posterior roots potentials (prp). the initial effect of morphine and promedol in doses of 1--3 and 0.5--1 mg/kg, respectively was not only a longer duration (by 30--40 msec), but also a higher amplitude of the prp, evoked by the stimulation of the sensomotor cortex. phentanyl used in a dose range of 0.01 to ... | 1975 | 6309 |
| effect of narcotic analgesics on the cortical control process of impulse transmission in the afferent pathways of the sciatic nerve. | the effect produced by narcotic analgetics with their intravenous administration on the process of cortical control over the transmission of impulses along specific routes of the sciatic nerve was studied. the conditioning stimulation of the cortex was effected by using a monopolar electrode through single electric impulses. the interval between conditioning and test (on sciatic nerve) impulses was of 80-120 ms. morphine (1-2 mg/kg), promedol (trimeperidin) (1-2 mg/kg) and phentanyl (100 gamma/k ... | 1976 | 6310 |
| the effects of electrical stimulation of the nuclei of the vagus nerves in anesthetized and unanesthetized cats. | | 1976 | 6344 |
| the adrenergic receptors of the intraocular muscles of the human eye. | the adrenergic receptors in man were analyzed using isolated sphincter, dilator, and ciliary muscle strips, dissected from eyebank eyes. the dilator is mainly alpha, the sphincter both alpha and beta, and the ciliary muscle predominantly beta adrenergic. | 1976 | 6403 |
| isocratic separation of some purine nucleotide, nucleoside, and base metabolites from biological extracts by high-performance liquid chromatography. | separation of atp, adp, amp, adenine, adenosine, camp, itp, idp, imp, hypoxanthine, inosine, cimp, the guanine series, nad, nadph, xanthine, 3-methylxanthine, theobromine, theophylline, and caffeine was accomplished using high-performance liquid chromatography with a microparticulate reversed-phase column. under isocratic conditions all compounds could be eluted with reasonable resolution and retention time. quantitation by peak height for several of the compounds was used to the 10-ng level. | 1976 | 6484 |
| gamma-aminobutyric acid: the essential mediator of behaviour triggered by neostriatally applied apomorphine and haloperidol. | | 1976 | 6658 |
| metiamide-treatment of brain oedema in animals exposed to 90yttrium irradiation. | | 1976 | 6680 |
| the effects of angiotensin i and angiotensin ii on the isolated tracheal muscle of the cat. | the effects of asp1-beta-amide-val5-angiotensin ii (a ii) and asp1-ile5-angiotensin i (a i) have been studied on the isolated continuously superfused cat tracheal muscle contracted by 5-hydroxytryptamine (5-ht). both peptides have been shown to induce dose-dependent relaxation on this muscle. similar effects have been obtained with synthetic bradykinin, prostaglandin e2 (pge2), noradrenaline and histamine. the effects of bradykinin, a i and a ii have been shown to be inhibited by aspirin but not ... | 1976 | 6719 |
| sympathomimetic bronchodilators and animal models for assessing their potential value in asthma. | | 1976 | 6741 |
| modern views on the pathogenesis of fever and the mode of action of antipyretic drugs. | | 1976 | 6743 |
| differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system. | in gallamine-immobilized cats, the caudate nucleus and the nucleus accumbens septi were perfused by means of a push-pull cannula and dopamine was measured in the perfusate. chlorpromazine (10 mg kg(-1)) and clozapine (20 mg kg(-1)), administered intravenously, enhanced the release of dopamine. the effect of chlorpromazine was similar in both regions whereas that of clozapine was more pronounced in the nucleus accumbens than in the caudate nucleus. furthermore, in the rat, sulpiride, clozapine an ... | 1976 | 6752 |
| arrhythmias and antiarrhythmic drugs: mechanism of action and structure-activity relationships ii. | | 1976 | 6770 |
| monoamine oxidase inhibition and the induction of ponto-geniculo-occipital wave activity by reserpine in the cat. | reserpine induces ponto-geniculo-occipital wave activity similar to that seen in the cat during the rapid eye movement phase of sleep. this action of reserpine was blocked by the monoamine oxidase inhibitors, pheniprazine, harmaline and clorgyline, but not deprenyl or its demethylated analog. after a single dose (20 mg/kg) of either pheniprazine or harmaline, the time course of antagonism of the effect of reserpine was in good correspondence with inhibition of monoamine oxidase but not with rest ... | 1976 | 6784 |
| effect of fatty acids on the disposition of ammonia. | subcoma doses of fatty acids and ammonium salts injected intraperitoneally at the same time into rats or cats act synergistically to produce coma. under these circumstances, the blood ammonia, is more than double that when the nh4+ is given alone. after these observations a rat liver homogenate system was utilized to study the effect of fatty acids on ammonia utilization in urea, glutamate and glutamine synthesis in vitro. acetylglutamate-catalyzed urea synthesis was completely inhibited by 45 m ... | 1976 | 6789 |
| the potentialities of some antihistaminics in preanaesthetic medication. | a detailed study has been carried out on the potentialities of antazoline and chlorpheneramine (c.p.m.) in preanaesthetic medication. it included a determination of their sedative action, effects on cardiovascular system and any possible anticholinergic and antiarrhythmic properties. both drugs depressed spontaneous activity in mice. antazoline produced hypotension in chloralosed dogs and spinal cats (a peripheral action). both produced a negative inotropic action on isolated rabbit's heart. on ... | 1975 | 6857 |
| adenylate cyclase and gastric acid secretion. | | 1976 | 6866 |
| possible actions of opiates upon synapses. | | 1976 | 6994 |
| is there a sleep transmitter? | | 1976 | 6995 |
| species and phenobarbitone-induced differences in the kinetic constants of liver microsomal harmine o-demethylation. | 1. the apparent kinetic constants for the o-demethylation of harmine to harmol by 10 000 g supernatant fractions from livers of mice, rats, guinea-pigs, rabbits, cats and cows have been determined. the km values were 10-39 mum and vmax 0-25 and 1-65 nmol/mg protein/min. 2. optimal conditions of incubation time and nadp requirements differed between species. in all species except cat and cow the rate of o-demethylation of harmine was linear for 5 min, but in the latter species was linear for 15 m ... | 1976 | 7043 |
| dynamics of the neurohumoral reactions of resistive and capacitive vessels in the process of adaptation to high altitude conditions. reactions to the intra-arterial administration of vasoactive substances. | | 1975 | 7084 |
| central noradrenergic control of blood pressure. | | 1976 | 7183 |
| the effects of amiodarone, an alpha and beta receptor antiagonist, on adrenergic transmission in the cat spleen. | | 1976 | 7261 |
| selectivity of beta-adrenoceptor agonists and antagonists on bronchial, skeletal, vascular and cardiac muscle in the anaesthetized cat. | 1 the potencies of fifteen beta-adrenoceptor agonists of widely differing chemical structures were compared with that of (-)-isoprenaline on bronchial muscle, soleus muscle, blood pressure and heart rate in the anaesthetized cat. the beta-adrenoceptor antagonist potencies of propranolol and practolol were determined against (-)-isoprenaline in the same model. 2 (-)-isoprenaline was the most potent agonist and its action was essentially unselective. thus, on all four parameters the minimal effect ... | 1976 | 7334 |
| substitution of the bladder-wall by means of deep-frozen heterologous skin grafts. experimental studies in domestic cats. | | 1976 | 7540 |
| failure of autonomic and central nervous system blocking agents to antagonize the gross behavioural effects of tubocurarine injected intraventricularly in conscious cats. | | 1976 | 7654 |
| interpretation of regional changes in brain dopamine after stimulation. | | 1976 | 7663 |
| changes in excitability of amygdaloid and septal nuclei induced by medazepam hydrochloride. | electrical stimulations of the central and basolateral part of the amygdaloid complex and of the septum in freely moving cats elicit changes in arterial pressure (i.e., an increase in pressure during stimulation of the central part of the amygdala, and a decrease followed by an increase during stimulation of the basolateral part of the amygdala and of the septum). these changes within the cardiovascular system are followed by rage reactions when the central part of the amygdala is stimulated, de ... | 1976 | 7798 |
| the main pharmacological characteristics of grandaxin (tofizopam, egyt-341). | | 1975 | 7851 |
| "respiratory physiology and physiopathology". | | 1975 | 7914 |
| release of amino acids from the spinal cord in vitro and in vivo. | | 1976 | 7928 |
| biochemistry of the basal ganglia. | | 1976 | 7932 |
| convulsant drugs and inhibitory mechanisms in the mammalian central nervous system. | | 1975 | 8019 |
| general pharmacological properties of a new non-opiate antitussive: zipeprol (3024 cerm). i. action on respiratory function and acute toxicity. | 1-(2-methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, respilene) is a substance of non-phenanthrenic chemical structure. in the cat, it antagonised cough induced by stimulation of the superior laryngeal nerve or by direct mechanical excitation of the sensitive tracheo-bronchial receptors. the efficacy of zipeprol after enteral administration made it possible both to establish good intestinal absorption and to rank it favourably in relation to s ... | 1976 | 8057 |
| actions of narcotics on brain dopamine metabolism and their relevance for "psychomotor" effects. | a review is given about the effects of narcotic analgesics, particularly of morphine, on the dopamine metabolism in the corpus striatum and about the relations of these effects to motility and "psychomotor" phenomena. in rats, acute doses of morphine decrease the dopaminergic neurotransmission in brain, without blocking postsynaptic dopamine receptors. chronic treatment of rats with morphine reverses these acute effects of morphine and induces symptoms of an increased dopaminergic neurotransmiss ... | 1976 | 8059 |
| light-evoked release of glycine from cat and rabbit retina. | the light-evoked release of 3hglycine from retina in cat (in vivo) after pre-retinal perfusion and in rabbit (in vitro) after intravitreal injection was studied. the site of uptake of 3hglycine into retina was checked by autoradiography and was found to be almost exclusively in a type of amacrine cells. if the retina loaded with 3hglycine was stimulated by light flashes the release increased significantly in both in vivo and in vitro experiments. when the flashing light was exchanged for continu ... | 1976 | 8192 |
| arylesterases from various mammalian sera in relation to cholinesterases, carboxylesterases and their activity towards some pesticides. | | 1976 | 8268 |
| anesthetic effects and elimination of tricaine methanesulphonate (ms-222) in terrestial vertebrates. | | 1976 | 8271 |
| hypotensive responses following oral adminstration of beta-adrenoceptor blocking drugs to the conscious cat. | on oral administration, the non-selective beta-adrenoceptor blocking drugs (+/-)-bufuralol, (-)-bufuralol, propanolol, oxprenolol, pindolol and alprenolol produced hypotensive responses in the conscious cat; (+)-bufuralol was without effect. the selective beta-adrenoceptor blocking drugs practolol and atenolol had no effect on blood pressure but tolamolol elicited a hypotensive response. all the drugs tested reduced the tachycardia due to intravenous isoprenaline in the conscious cat; however, n ... | 1976 | 8319 |
| ultrastructural localization of acid phosphatase and thiamine pyrophosphatase activities and of phosphotungstic staining at low ph in the placental labyrinth of the cat. | the localizations of acid phosphatase (acpase) and thiamine pyrophosphatase (tppase) activities were studied in the placental labyrinth of the cat during the last days of gestation. acpase activities were observed essentially in the syncytiotrophoblast and in the "interstitial inert substance" (s.i.i.) that separates maternal from foetal tissues. reaction product was localized in lysosomes, multivesicular bodies, and in the network of smooth-membraned tubules which open on the cell surface of th ... | 1976 | 8410 |
| activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions. | bilateral electrolytic lesions of the lateral hypothalamus or intraventricular 6-hydroxydopamine injections produced substantial depletions of striatal dopamine in rates. all animals with brain damage showed marked sensorimotor impairments. however, they began to move and respond appropriately to environmental stimuli when placed in a sink of water, in a shallow ice bath, or among a colony of cats or rats. a reversal of the sensorimotor dysfunctions was still apparent shortly after the animals w ... | 1976 | 8470 |
| desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline. | desensitization of kitten atria with 30mum (-)isoprenaline resulted in a 6-fold and 15-fold increase in the ec50's of (-)isoprenaline for its positive chronotropic effects (sinus pacemakers) and positive inotropic effects (left atria), respectively, but only in a 2-fold increase of the ec50 of (-)isoprenaline for adenylyl cyclase stimulation in membrane particles from atria. however, maximum cyclase stimulation by (-)isoprenaline was decreased to 1/2 in membranes from (-)isoprenaline-treated atr ... | 1976 | 8737 |
| ph sensitivity of cells located at the ventrolateral surface of the cat medulla oblongata in vitro. | ph sensitivity of cells located at the ventral surface of the medulla oblongata was examined in a thin brain slice of the cat in vitro and the following results were obtained: (1) transmembrane potential of the surface cells located in the area medial to the xiith cranial nerve was reduced slightly by application of low ph solution; (2) in the rostral part of the area medial to the xiith cranial nerve regular neuronal discharges could be observed extracellularly. the rate of firing of these cell ... | 1976 | 8766 |
| acetylsecohemicholinium: chemical and pharmacological evaluation of an open-ring hemicholinium. | acetylsecohemicholinium no. 3 (achc-3), the acetate of the open ring (seco form of hemicholinium no. 3, hc-3) hydrolyzes in vitro to the hemiacetal hc-3 at ph values above 9, a temperature-dependent conversion illustrated by ultraviolet spectral shifts from 305 to 257 mmu, and to a limited extent by certain esterases as measured by manometric analysis. an ld50 of 125 mug/kg for a neutral solution of achc-3 was decreased to 78.3 mug/kg (the ld50 of hc-3) upon being made basic. prolonged treatment ... | 1976 | 8797 |
| voraciousness induced in cats by benzodiazepines. | different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. pentobarbital also stimulated food intake, but was much less potent than the benzodiazepines tested. | 1976 | 8810 |
| effect of blood ph on the various effects of catecholamines. | | 1975 | 8852 |
| feline reproduction. | | 1976 | 8865 |
| effect of arterial hypoxia and acidosis on fibrillation threshold in the cat heart in vivo. | the influence of severe arterial hypoxia and acidosis on the fibrillation threshold was checked in 22 cats. two groups were formed: in 10 cats (group i) acidosis was produced by 2-n lactic acid infusion; in the second group of 12 animals the respirator was turned off for 60 seconds, thus producing a low arterial po2. if hypoxia and acidosis were severe enough, the fibrillation threshold was significantly lowered in either group. the pathophysiological mechanisms of these findings are discussed. | 1976 | 8885 |
| dynamics of the neurohumoral reactions of the resistive and capacitive vessels in the process of adaptation to high mountains. iv. the role of adrenoreceptors (an experimental study). | | 1976 | 8900 |
| influence of ph and pco2 on alpha-receptor mediated contraction in brain vessels. | the response of isolated brain vessels to various ph levels or carbon dioxide tensions was analyzed. reduction of the ph induced a slight relaxation of the vessel, whereas an increase in the ph produced a slight contraction. these effects were markedly exaggerated when the alpha-adrenergic receptors in the vascular wall were activated by noradrenaline. during these conditions the contractile response to noradrenaline was reduced by about 40% at a ph of 7.01, while, on the other hand, the respons ... | 1976 | 8955 |
| bêta-adrenoreceptor blocking properties of 1-nitro, hydroxy phenyl, n-benzoyl alanine (gal-1). | | 1976 | 9003 |
| sympathomimetic-induced effects in the soleus muscle of the guinea-pig. | sympathomimetic amines reduced the peak tension, time to peak and time to half-relaxation of indirectly elicited twitches of the guinea-pig soleus muscle in vivo. clonic contractions of the soleus muscle were depressed by the amines. on a molar basis salbutamol and orciprenaline were 5.12 and 80.0 times less potent than (+/-)-isoprenaline in producing these effects. results obtained with the beta-receptor antagonists propranolol, practolol and h35/25 suggest that the depression in skeletal muscl ... | 1976 | 9032 |
| mesenteric vasodilator effect of 5-hydroxytryptamine: possible enteric neuron mediation. | the superior mesenteric blood flow response to intra-arterial injections (0.5-25 mug) and infusions (5-30 mug/min) of 5-hydroxytryptamine (5-ht, serotonin) was investigated in anesthetized cats in which nerve activity to the intestine was altered by surgical and pharmacological procedures. with the superior mesenteric periarterial nerves intact, low doses of 5-ht (less than 5 mug) produce vasodilatation, whereas higher doses produce vasoconstriction. when the periarterial nerves are cut either a ... | 1976 | 9034 |
| species differences in the conjugation of 4-hydroxy-3-methoxyphenylethanol with glucuronic acid and sulphuric acid. | the biosynthesis of the glucuronide and sulphate conjugates of 4-hydroxy-3-methoxyphenylethanol was demonstrated in vitro by using the high-speed supernatant and microsomal fractions of liver respectively. these two conjugates were also produced simultaneously by using the post-mitochondrial fraction of rat, rabbit or guinea-pig liver. in contrast only the glucuronide was synthesized by human liver and only the sulphate by mouse and cat livers. neither of these conjugates was formed by the kidne ... | 1976 | 9078 |
| interaction of psychotropic agents with central neurotransmitters as revealed by their effects on pgo waves in the cat. | one of the phasic phenomena of rem (rapid eye movement) sleep, the ponto-geniculo-occipital (pgo) waves, are induced in cats by either depleting brain monoamines with the benzoquinolizine derivative ro 4-1284 or inhibiting the synthesis of 5-hydroxy-tryptamine (5-ht) by p-chlorophenylalanine (pcpa). the effects of the most important psychotropic agents on pgo1284 and pgopcpa are reported and explained by their interaction with one or more of the 4 neurotransmitters known so far to be involved in ... | 1976 | 9104 |
| proceedings: the role of ions in the regulation of pial arterial diameters. | | 1976 | 9116 |
| effect of duodenal acidification on gastric mucus and acid secretion in conscious cats. | in cats with gastric fistulae and heidenhein pouches, the effect of acid entering the duodenum on secretion of acid, pepsin, and mucus from the heidenhain pouch during maximal acid stimulation with pentagastrin or histamine, was studied. duodenal acidification produced stimulation of pepsin and mucus secretion comparable to that induced by exogenous hormones (secretin and the combination of secretin with cholecystokinin). in addition, duodenal acidification caused an increase in acid secretion, ... | 1976 | 9325 |
| gastric mucosal lesions produced by intravenous infusion of aspirin in cats. | aspirin was given by continuous intravenous infusion to 35 intact cats for 7 days in doses ranging from 25 to 200 mg kg-1 day-1. gastric mucosal lesions occurred in 50 to 70% of the animals in the various dosage groups, including deep ulcers in 20%. all of the ulcers were in antral mucosa near its border with oxyntic mucosa. the incidence of lesions, including ulcers, showed no apparent relation to the dose of aspirin. with all but the highest dose, plasma salicylate levels were within or below ... | 1976 | 9330 |
| analysis of passive and active electrophysiologic properties of neurons in mammalian nodose ganglia maintained in vitro. | 1. we studied the passive and active electrical properties of the soma membrane of neurons in nodose ganglia removed from cats and rabbits and maintained in vitro. the ganglia were superfused at 37 degrees c with a solution formulated to approximate the extracellular fluid of each species. the solution was buffered to ph 7.34, continuously equilibrated with 95% o2 and 5% co2, and contained dialyzed calf serum and glucose. we also examined these properties in nodose ganglion neurons in vivo. intr ... | 1976 | 9491 |
| bandage-backfall reaction: occurs in infancy, hypothalamic damage, and catalepsy. | in cataleptic clinging, produced either by catecholamine-blocking drugs or lateral hypothalamic damage in adult cats, rats, or monkeys, bandaging the face and neck causes the head to fall backwards. early in development, a similar reaction can be seen in normal undrugged infants. | 1976 | 9643 |
| effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. | the effects of anti-aggressive agent sch 12679 were evaluated upon stable baselines of rage and predation elicited by electrical stimulation of the hypothalamus in cats. sch 12679 depressed approach and terminal aspects of both forms of attack. this is consistent with previous reports, and suggests the drug is effective in reducing many forms of aggression including brain stimulated emotional behavior. | 1976 | 9658 |
| disorders of micturition: neuropharmacologic basis and results of drug therapy. | the clinical use of various pharmacologic agents in problems of micturition is based on the new concepts of intrinsic urethrovesical innervation, presence and regional predominance of autonomic neuroreceptors, and experimental evidence of the effects of various drugs on the bladder and the urethra. a new concept, relating to the processes that control bladder filling and emptying, is coming into being and replacing the traditional concept based on anatomic grounds alone. on the basis of the publ ... | 1976 | 9724 |
| new approaches to the study of the neurochemical basis of sleep and wakefulness. | | 1976 | 9792 |
| pulmonary surfactants. generalities. | the alveolar wall on contact with air can be compared with a biological air-liquide interface. as with all interfaces, there are therefore superficial forces which tend to reduce the surface to a minimum. in the case of a pulmonary alveolus with a spherical surface, these forces are at the origin of an internal pressure excess dependent on the radius of the alveolus and on the superficial tension related to the nature of the interface. owing to the disparity in the alveolar radii, under these co ... | 1975 | 9871 |
| alterations of cat papillary muscle mechanics induced by changes of preload under variation of physical and chemical parameters (author's transl). | a rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. the opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium. the stretch-induced process of relaxation is accompanied by a transient decrease in mechanogram amplitudes; a release is accordingly followed by a temporary increase in isometric m ... | 1976 | 9930 |
| isoprenaline antagonism of cardioselective beta-adrenergic receptor blocking agents on human and rat adipocytes. | 1. the beta-adrenergic blocking potencies of practolol, ici 66082, tolamolol, acebutolol, h 93/26, h 87/07, pindolol and ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. a good correlation was found between the potencies on adipocytes of the two species but not between our results and literature data on antagonism of isopernaline tachycardia in the anaesthetized cat. 3. the results indicate that differences between adrenergic beta-receptors in heart and adipose t ... | 1975 | 9950 |
| gaba antagonism as a possible basis for the convulsant action of a series of bicyclic phosphorus esters proceedings. | | 1976 | 10031 |
| the cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. | 1 a new in vitro preparation, the isolated lung strip of the cat, is described for investigating the direct effect of drugs on the smooth muscle of the peripheral airways of the lung. the preparation comprises a thin strip of lung parenchyma which can be mounted in a conventional organ bath for isometric tension recording. its pharmacological responses have been characterized and compared with the isolated tracheal preparation of the cat. 2 the lung strip exhibited an intrinsic tone which was re ... | 1976 | 10035 |
| behaviourism: a framework for common sense therapy. | | 1976 | 10046 |
| influence of variations in blood ph on the bronchodilator action of salbutamol and terbutaline. | in the cat, the broncho-dilatator effects of salbutamol and terbutaline are influenced by blood ph variations. gazeous or metabolic alkalosis increases, acidosis decreases, the broncho-dilatation provoked by salbutamol or terbutaline. | 1976 | 10056 |
| absorption and malabsorption of folates. | folic acid is one of the 'younger' vitamins, yet it has attracted intensive study in the thirty years since the identification of pteroylglutamic acid and its polyglutamyl conjugates. the absorption and malabsorption of folates, natural, purified and synthetic, in disease has been studied more than any other vitamin and indeed folate absorption has become one clinical test of intestinal function. we know little about the release of folate from protein complexes, but we have learned, with the hel ... | 1976 | 10121 |
| chemical stimulants of shaking behaviour. | | 1976 | 10386 |
| effect of histamine and antihistamines on renal hemodynamics and functions in the isolated perfused canine kidney. | histamine was infused intra-arterially (10-40 mug/min) into isolated blood perfused canine kidneys while functional and hemodynamic parameters were monitored. when perfusion pressure (pp) was kept constant during the infusion of histamine, renal blood flow (rbf) increased from 137 +/- 9 to 181 +/- 9 ml/min (p less than .001). a greater increase in rbf occurred to the inner renal cortex than the outer renal cortex as measured by radioactive microspheres. the fractional outer/inner cortical blood ... | 1976 | 10420 |
| a polypeptide (ap-a) from sea anemone (anthopleura xanthogrammica) with potent positive inotropic action. | anthopleurin-a (ap-a), a polypeptide with mw ca. 5500 (53 amino acids), isolated from the sea anemone, anthopleura xanthogrammica (brandt), elicited a potent positive inotropic effect but without an accompanying chronotropic effect on the isolated cardiac muscles of rat, rabbit, guinea pig and cat. similarly in dogs and cats in situ, i.p. injections of ap-a increased the contractile force without effect on heart rate or blood pressure. the cardiotonic potency for ap-a was equivalent to that of i ... | 1976 | 10426 |
| beta-adrenergic blocking agents. 13. (3-amino-2-hydroxypropoxy)benzamides. | | 1976 | 10440 |
| influence of low extracellular ph upon the ca inward current and isometric contractile force in mammalian ventricular myocardium. | in isolated papillary muscles of cats the changes in ca inward current and isometric contractile force following a decrease of extracellular ph from 7.4 to 5.5 were studied. the ca current was analyzed (a) by measuring the upstroke velocity of ca-mediated action potentials and (b) in voltage clamp experiments using the double sucrose gap technique. 1. at a ph of 5.5 the upstroke velocity of the ca-mediated action potential decreased to 65% of the control, while overshoot and action potential dur ... | 1976 | 10549 |
| sympathomimetic bronchodilator drugs. | | 1976 | 10580 |
| mucociliary function in the respiratory tract as influenced by physicochemical factors. | | 1976 | 10581 |
| oestral behaviour in a bilaterally cryptorchid cat. | | 1976 | 10667 |
| glutamine synthetase and glutamyltransferase in the kidney of man, dog, and rat. | glutamine synthetase (gs) is known to exist in the kidney of the rat, guinea pig, rabbit, and sheep but not in that of the dog, pig, cat, or pigeon. no data is available in man. assay of histologically normal renal tissue obtained in human subjects during surgery for abdominal vascular disease failed to demonstrate significant gs activity. in addition, l-glutamine gamma-glutamyltransferase (gt) activity was also very low. the same results were observed in the dog, in which both gs and gt activit ... | 1976 | 10736 |
| inhibition of inotropic effect of hyperosmotic mannitol by lactate in vitro. | isolated, isometrically contracting cat papillary muscles were used to evaluate the inotropic interactions of lactic acidosis, hypercarbic acidosis, and lactate ion with hypertonic mannitol. these studies have documented that both lactic acidosis (ph less than 7.0) and lactate ion at a normal ph inhibit the inotropic effect of hyperosmotic mannitol in vitro. in contrast, hypercarbic acidosis does not prevent the inotropic effect of mannitol. inhibition by lactic acid of mannitol's effects on con ... | 1976 | 10739 |
| lack of a significant protective effect of augmented circulating glucose on the ischemic myocardium. | this was a 60 year old woman, with a very large retro-pharyngeal tumour, mainly situated on the right, revealed by chronic decompensated respiratory failure. admission to hospital was justified by deep coma with cyanosis of the face and extremities. she had taken 50 mg of oxazepam the day before admission to hospital. this coma was due to chronic respiratory failure decompensated, as suggested by clinical and laboratory examination after elimination of any traumatic, neurological, endocrine or m ... | 1976 | 10821 |
| selective blocking properties of chloro acetyl catechol (cac) on the alpha-adrenergic receptor. | in anesthetized rats and cats chloro acetyl catechol (cac, 10 mg/kg i.v. and 10-15 mg/kg i.v., respectively) selectively blocked the arterial hypertensive responses to epinephrine. no adrenergic blockade was produced by cac in rats pretreated with 20 mg/kg i.p. of the compound 24 hr before the experiment. norepinephrine-induced contractions of the rat vas deferens and the rat seminal vesicles in vitro were blocked by cac 10(-4) m. the blockade was prevented by the simultaneous addition of norepi ... | 1976 | 10863 |
| metabolism of lorazepam. | the metabolism of lorazepam by man and four other species is reviewed. lorazepam and its metabolites in blood, urine and faeces were identified by thin-layer and gas chromatography and by mass spectrometry. the principal metabolite in man, dog, pig and cat is the glucuronide, but the rat produces other metabolites after small doses of lorazepam, and significant amounts of the glucuronide only after high doses. since all metabolites, except the glucuronide, occur in small quantities only in man, ... | 1976 | 10938 |
| analgesia produced by morphine when acting from the liquor space. | 1 in cats analgesia was produced by morphine sulphate introduced into different parts of the liquor space in doses too small to be effective on intravenous injection. analgesia was measured with the tail pinch method of russell & tate (1975). 2 on infusion into the fourth ventricle or into the subarachnoid space beneath the ventral surface of the brain stem caudal to the pons, doses of 100 to 200 mug of morphine sulphate were sufficient to produce strong long-lasting analgesia. on injection into ... | 1976 | 11018 |
| effects of activation of h1-and h2-receptors on central cardiovascular structures in cats and on behaviour in chickens proceedings. | | 1976 | 11025 |
| reduced hemoglobin affinity for oxygen in venous blood following hemodilution, independent of changes in ph or pco2. | a rapidly induced and readily reversible shift in the affinity of hemoglobin for oxygen has been demonstrated. the shift, similar to the bohr effect, is independent of pco2 or ph changes. it occurred within 30 min of hemodilution and was seen in portal venous blood but not arterial blood. a hypothesis is suggested involving a phasic alteration in levels of 2,3-diphosphoglycerate (dpg) or atp binding to hemoglobin. it is proposed that, following hemodilution, the degree of these phosphates to hem ... | 1976 | 11042 |
| centrally induced reduction in sympathetic tone-a postsynaptic alpha-adrenoceptor-stimulating action of imidazolines. | naphazoline or oxymetazoline (both 30 mug/kg) were injected into the cisterna magna of anaesthetized cats and reduced blood pressure, heart rate and the electrical discharge rate of small fibre bundles of the preganglionic sympathetic splanchnic nerve. cats were depleted of endogenous noradrenaline by pretreatment with reserpine (5 mg/kg, 18 h) and alpha-methyl-p-tyrosine (twice 300 mg/kg, 18 and 2 h). in these animals, intracisternal injection of 30 mug/kg oxymetazoline exerted a decrease of sy ... | 1976 | 11108 |
| effects of ouabain on arterial pressure and its modification by tetrodotoxin. | | 1976 | 11299 |
| the elastic constants and ultrastructural organization of a basement membrane (lens capsule). | | 1976 | 11468 |
| the spontaneous activity of neurones in the cat's cerebral cortex. | | 1976 | 11486 |
| the effects of changing levels of arousal on the spontaneous activity of cortical neurones: i. sleep and wakefulness. | | 1976 | 11487 |
| the effects of changing levels of arousal on the spontaneous activity of cortical neurones. ii. relaxation and alarm. | | 1976 | 11488 |
| effects of narcotic analgesics on contractile function of isolated cardiac muscle. | | 1976 | 11502 |
| antiadrenergic actions of metiamide in cat thermoregulatory mechanisms. | | 1976 | 11506 |
| possible association of schizophrenia with a disturbance in prostaglandin metabolism: a physiological hypothesis. | schizophrenia may be associated with increased prostaglandin synthesis in certain parts of the brain. this hypothesis is based on the following findings: (1) catalepsy, which is the nearest equivalent in animals to human catatonia, develops in cats when prostaglandin e1 is injected into the cerebral ventricles and when during endotoxin or lipid a fever the prostaglandin e2 level in cisternal c.s.f. rises to high levels; however, when fever and prostaglandin level are brought down by non-steroid ... | 1976 | 11519 |
| structure-activity relationship studies of derivatives of aminotetralins and open chain analogs in relation to beta and alpha-adrenoceptor agonist activities. | some derivatives of aminotetralins and their open chain analogs were tested for their ability to alter blood pressure and heart rate in anesthetized cats with both vagi nerves sectioned and their ability to relax tracheal smooth muscle of guinea-pigs. tl-257 and jod-213, tertiary amines, produced weak alpha-adrenoceptor stimulating activity while jod-176 and jod-211, secondary amines, showed beta-adrenoceptor stimulating activity. another compounds, m-8, an aminotetralin that is a secondary amin ... | 1976 | 11757 |
| appetite stimulant activity of 3-carboxy-10,11-dihydrocyproheptadine. | the orexigenic and ancillary pharmacologic properties of 3-carboxy-10,11-dihydrocyproheptadine (cdc) were compared to those of cyproheptadine. the threshold dose, 0.0312 mg/kg p.o., of cdc for increasing food intake in the cat is similar to that of cyproheptadine, but cdc has a broader effective dose range, extending to 8 mg/kg p.o., compared with 1 mg/kg p.o. for cyproheptadine. using an increase in food consumption of 20% or more as the criterion of a positive response, the dose effective in 5 ... | 1976 | 11758 |