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[effect of stress-inducing factors on the behavior of monkeys. i. the behavior of monkeys under acute emotional stress].the behavior of papio hamadryas pubertal males under the immobilizational stress conditions has been studied. it has been established that this very type of stress appeared to be a powerful irritant for the individuals of this species and age leading them into the depression state. the process of normalization of behavior after the 2-hour immobilization lasted for about 72 h. the main consequences of the stress were the violation of locomotion, the reception by individuals of unnatural postures, ...19854040775
[some data on the nature of cortisol metabolism in macaca rhesus monkeys and hamadryas baboons]. 19714330564
the epidemiologic and genetic aspects of an outbreak of leukemia among hamadryas baboons of the sukhumi monkey colony. 19734360160
[experimental prenatal treatment of hemolytic disease of the newborn in monkeys (papio hamadryas)]. 19724623476
[phasic analysis of cardiac activity in rhesus monkeys and hamadryas baboons]. 19724624905
comparative features of the reproductive biology of hamadryas baboons (papio hamadryas), grivet monkeys (cercopithecus aethiops) and rhesus monkeys (macaca mulatta). 19724627306
the use of hamadryas baboons for the study of the immunologic aspects of human reproduction. 19724627311
the velocity of the pulse wave distribution and arterial piesography in adult hamadryas baboons and rhesus monkeys. 19694981656
the cape western baboon in organ allotransplantation. 19705000235
[circadian rhythms of androgen levels in the blood of male hamadryas baboons].radioimmunoassay was used to investigate circadian rhythms of blood plasma testosterone, 5 alpha-dihydrotestosterone, androstendione and dehydroepiandrosterone in intact animals and in those preadapted for experimental conditions. blood plasma of monkey demonstrated monophasic circadian rhythms in the levels of androstendione, dehydroepiandrosterone and 5 alpha-dihydrotestosterone, with the maximal values seen early in the morning and minimal values in the evening. circadian rhythms of testoster ...19846229295
lymphocyte sensitization detected in lymphomatous hamadryas baboons by the macrophage electrophoretic mobility assay.peripheral blood lymphocytes from lymphomatous or control papio hamadryas monkeys were incubated in the presence of kcl-extracted proteins prepared from allogeneic lymphomatous or normal lymph nodes and from a spontaneous baboon hepatoma. only the lymphomatous baboon lymphocyte-lymphoma antigen interaction product(s) significantly reduced the anodic electrophoretic mobility of guinea pig macrophages.19806244991
[encephalomyocarditis in hamadryas baboons].in 1978--1979, four cases of encephalomyocarditis were recorded in baboons in a simian preserve of the ussr ams research institute of experimental pathology and therapy located in the zapadnyaya gumista river valley. the diagnosis was made on the basis of virological and pathomorphological examinations. the isolate recovered from the dead monkeys was identical with the prototype strain of encephalomyocarditis virus (emc) and the emc-70 strain previously isolated by us from m. rhesus monkeys. the ...19826291247
enzyme-linked immunosorbent assay for detection of antibodies to epstein-barr virus antigens.enzyme-linked immunosorbent assay (elisa) was standardized for measurement of antibody activity of reference human and baboon (papio hamadryas) sera to soluble epstein-barr virus (ebv) antigens. a comparison with the immunofluorescent (if) method showed that elisa detects antibody specifically and sensitivity. in elisa, herpesvirus papio (hvp) nuclear antigen (hupna) positive baboon serum reacted with ebv nuclear antigen (ebna), as a further indication of the antigenic similarity between hvp and ...19836318497
[etiological aspects of leukemias in primates including man].attempts have been made to induce viral leukemia in monkeys (papio hamadryas and macaca arctoides) by inoculating them with blood from humans with different types of leukemias. in hamadryas baboons, the disease spread horizontally. by today 218 p. hamadryas and 5 m. arctoides monkeys had died of malignant lymphoma. the following viruses have been isolated from sick monkeys: lymphotropic baboon herpes virus (hvp), endogenous baboon c type viruses--xenotropic (biln), and ecotropic (evpg). c type o ...19836318850
[study of virus-associated lymphomas in primates using a model of malignant lymphoma of the baboon].an outbreak of malignant lymphoma was registered in a population of hamadryas baboons. animals inoculated with blood from patients with various forms of leukemia were planted into the stock 10 years ago. 218 out of 3219 animals have already died from lymphoma. the morphological pattern of horizontally-spreading lymphoma was similar to basic cell patterns of hodgkin's and non-hodgkin lymphoma in man. as far as the immunologic classification of tumor lymphoid cells is concerned, baboon lymphomas w ...19836320540
[effect of luliberin and chorionic gonadotropin on luteinizing hormone and testosterone levels in the blood of monkeys under acute stress].the effect of immobilization stress on luteinizing hormone (lh) and testosterone (t) secretion following injections of luliberin (lh-rh) and human chorionic gonadotropin (hcg) was investigated in male hamadryas baboons. it was established that in control animals a single injection of hcg (4500 iu) led to a more prolonged and more demonstrable increase of plasma testosterone concentration than injection of a pharmacological dose (100 micrograms) of lh-rh. preliminary stimulation of the testes wit ...19846369303
new inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon.a new inhibitor of human renin (h. 189) is described. it is a decapeptide analogue of human renin substrate with the amino acid, statine, substituted for leucine in the scissile bond. its inhibitory potency as shown by ic50 is 1.0 x 10(-8) m with human plasma renin and 1.5 x 10(-8) m with baboon plasma renin. it is less effective with dog and rat renin, but its inhibitory potency with human renin is similar to that of another inhibitor of ours (h. 142) having a reduced isostere in the scissile b ...19836398331
fibrinopeptides a and b of baboons (papio anubis, papio hamadryas, and theropithecus gelada): their amino acid sequences and evolutionary rates and a molecular phylogeny for the baboons.amino acid sequences of fibrinopeptides a and b from savanna baboons, papio anubis and papio hamadryas, and highland baboon, theropithecus gelada, were established. the sequences of the fibrinopeptides a from the three baboons were identical: (sequence: see text) the fibrinopeptides b were composed of 9 residues and demonstrated the sequence: (sequence see text) where x3 = arg in p. anubis, his in p. hamadryas, and gly in th. gelada. position-3 of the b peptides was the only replacement site obs ...19836423621
[incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin b1].a mutagenic effect of aflatoxin b1 (afb1) was studied in somatic cells of primates. it is shown that afb1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: macaca mulatta and papio hamadryas. genome mutations were found in these experimental primates simultaneously with chromosome aberrations. the afb1-induced chromosome aberrations were revealed at least during two years of the study. the fact of the chromosome aberration frequency increase was established ...19846431671
frequency of chromosome aberrations in bone marrow of monkeys and their f1 after aflatoxin b1 injection.a mutagenic effect of aflatoxin b1 (afb1) in somatic cells of primates is investigated. it is shown that afb1 elevated the frequency of chromosome aberrations in the bone marrow of two species of monkeys: macaca mulatta and papio hamadryas. beside chromosome aberrations, genome mutations were found in these experimental primates. afb1-induced chromosome aberrations were constantly revealed during two years of study. increase in the frequency of chromosome aberrations could be demonstrated in mac ...19846440807
characterization of various molecular species of follicle-stimulating hormone in baboon pituitary preparations.the properties of baboon (papio hamadryas) follicle-stimulating hormone (bfsh) have been studied after isoelectrofocusing (ief) of individual pituitary extracts from five female and three male baboons and of a partially purified bfsh preparation (cm-1). the in vitro bioactivities of the female and male pituitary extracts and of cm-1 were 6.0 (range 4.1-9.6), 10.8 (6.9-18.2), and 34.1 (30.3-38.3) mg equivalent of ler 1909-2 reference standard per mg protein, respectively. the corresponding ratios ...19846440996
[effect of human chorionic gonadotropin on the endocrine function of papio testes].radioimmunoassay was used to study secretion of papio hamadryas testis under stimulation with human chorionic gonadotropin (hcg). it was discovered that hcg had an acute stimulating effect on testicular secretion of testosterone, androstendione and 17-hydroxyprogesterone. it was demonstrated that repeated stimulation with hcg in the presence of the maximal secretory response of the testis (24 h after the first injection and in the presence of its partial reduction (after 72 h) did not provoke an ...19846504879
[testicular endocrine function in hamadryas baboons (papio hamadryas) during chronic emotional stress].radioimmunoassay was applied to examine the time course of blood plasma testosterone content in 10 adult male hamadryas baboons under repeated immobilization stress (is). in the first series of experiments, the monkeys (5) were subjected to daily is for 2 h during 6 days. in the second series, 5 animals were exposed to 2-hour immobilization 3 days prior to the analogous stressful cycle. in response to intermittent is the first series males demonstrated profound and long-term suppression of blood ...19846538448
inbreeding effects on dental morphometrics in papio hamadryas.the dentition of nonhuman primates (papio hamadryas) was utilized to investigate the hypothesis that inbreeding will affect mean tooth size and shape. more than five hundred dental casts were collected from baboons at the institute of experimental pathology and therapy in sukhumi, ussr. in addition, inbreeding coefficients for each monkey were obtained from pedigree records, some going back seven to nine generations. each tooth was measured and scored for the presence of discrete morphological s ...19836650676
[characteristics of the adrenal endocrine function of papio hamadryas in the metopyrone test].hormonal function of the adrenals of preadolescent and adult monkeys (papio hamadryas) was examined by the metopyrone test. after a single injection of metopyrone the content of cortisol, 11-deoxycortisol, progesterone, pregnenolone, 17-hydroxyprogesterone and 17-hydroxypregnenolone was measured in the blood of monkeys by radioimmunoassay. the reasons for age-associated differences in the hormonal response of the primate adrenals to metopyrone injection are discussed. the conclusion is drawn on ...19846718337
[effectiveness of revaccinating hamadryas baboons with niss live dried plague vaccine and fraction i of the plague microbe].the effectiveness of some vaccine preparations for the revaccination of hamadryas baboons after their primary immunization with live plague vaccine " niis " administered in the form of aerosol was studied. the study was carried out under the conditions of the aerosol challenge of the animals with y. pestis. the subcutaneous injection of plague vaccine " niis " was found to have advantages over its aerosol administration. revaccination with y. pestis fraction i, absorbed, was found to be 8 times ...19846741359
antistreptococcal antibodies, rheumatoid factors and haptoglobin in apes and monkeys.sera of 157 baboons (papio hamadryas and p. anubis) 21 chimpanzees (pan troglodytes) five orang utans (pongo pygmaeus) three mountain gorillas (gorilla gorilla beringei) and three gibbons (hylobates lar lar) were examined for the content of antistreptolysin o, antidesoxyribonuclease b, for the presence of rheumatoid factors as well as for the level and type of haptoglobin. the mean antistreptolysin o titer (ast) in baboons was 106 asu +/- 18 in dextransulfate absorbed sera ("real" ast) and 182 a ...19806775442
immunohistochemical localization of fsh and lh in the pars distalis of vervet (cercopithecus aethiops) and baboon (papio hamadryas) pituitaries.antisera against olh, beta olh and beta hfsh were used to localize gonadotropic cells in the pars distalis of cercopithecus aethiops and papio hamadryas. three separate cell types were observed for fsh and lh: 85% of immunohistochemically identified gonadotropic cells reacted to all the various antisera; 10% reacted with the anti-beta olh antibody only; and 5% with the anti-beta hfsh antibody only. comparisons between adjacent serial sections treated with various antisera, other than anti-gonado ...19816786752
[biological characteristics of lymphoid cell lines producing lymphotropic primate herpesviruses].lymphoid cell lines of monkey and human origin were characterized by proliferative activity, electrophoretic mobility, and percentage of colony-forming cells. papio hamadryas cell lines were divided into two types similar to those of humans. one of them includes cell lines of tumor origin with high proliferative activity, decreased electrophoretic mobility, and a high percentage of colony-forming cells. the other type includes lymphoblastic lines of non-tumor origin with low proliferative activi ...19836845722
[structural organization of caudate-frontal relationships in lower monkeys].cellular structure of the caudate nuclei has been studied in intact monkeys (macaca rhesus and papio hamadryas) after bilateral extirpation of the frontal area fields. methods of retrograde cellular degeneration and quantitative analysis with application of the computer "klassimat" have been used. only in one macaca operated on, the frontal premotor and motor fields have been removed, in other monkeys the frontal fields have been predominantly removed. only in one macaca operated on, a statistic ...19817034692
[projections of the thalamic dorsomedial nucleus onto the prefrontal area of the cortex in hamadryas baboons].in 6 monkeys (papio hamadryas) by means of the retrograde degeneration method projections of the thalamic dorsomedial nnucleus on field 9, 10 and 47 in the prefrontal cortical area have been studied. morphological investigation of the frontal cerebral sections stained after nissl has demonstrated that multiform part of the thalamic dorsomedial nucleus makes projections towards field 9. the frontal superior sector of the parvocellular part of the dorsomedial ucleus is projected on field 10, and t ...19827115099
sexual dimorphism in two subspecies of ethiopian baboons (papio hamadryas) and their hybrids.sexual dimorphism in mammals has been related to such variables as absolute body size, ecology, and various aspects of social behavior. attempts to relate dimorphism to any of these variables have necessarily used small heterogeneous samples to represent the relevant species. we are concerned by the inevitable exclusion of any measure of variability in dimorphism and the consequent impossibility of assessing the significance of observed interspecific differences. in this paper we describe aspect ...19817325215
isolation of lymphotropic baboon herpesvirus (hvp) from oral swabs of hamadryas baboons of the sukhumi monkey colony.ways of lymphotropic baboon herpesvirus (hvp) secretion and its excretion into the environment were investigated. oral swabs and feces from the sukhumi main stock hamadryas baboons characterized by a high risk for malignant lymphoma and the baboon stock living in isolation in the forest were used as materials for the investigations. macaque groups of the sukhumi stock were used as controls. it could be shown that the hvp was resistent in the oral cavity of the main stock baboons and was isolated ...19807409079
a reassessment of the karyotype of papio ursinus. homoeology between human chromosome 15 and 22 and a characteristic submetacentric baboon chromosome.the giemsa-banded karyotype of the chacma baboon, papio ursinus, was shown to be identical to that of papio hamadryas. comparison of g-banded p. ursinus (pur) chromosomes with those of man (hsa) showed close morphological homoeology between pur and hsa chromosomes 5, 8, 12, 19, and x, and partial homology for seven and 22 and was the only papio chromosome containing a nucleolar organizer region (nor). this baboon chromosome, therefore, shows genetic homoeology with human acrocentrics for a least ...19807449436
a non-human primate study (baboon; papio hamadryas) to determine if a long-acting progestogen, levonorgestrel butanoate, combined with a long-acting androgen, testosterone buciclate, can suppress spermatogenesis: i. dose-finding study.this study in adult male baboons was conducted to establish the dose of a long-acting progestogen, levonorgestrel butanoate, and that of a long-acting androgen, testosterone buciclate, which, when combined, would achieve optimal and prolonged suppression of spermatogenesis. two intramuscular injections of levonorgestrel butanoate at 3-month intervals and in the dose range 1-8 mg/kg reduced sperm production and plasma concentrations of testosterone, lh and fsh for periods of up to 6 months. the s ...19957665213
a non-human primate study (baboon; papio hamadryas) to determine if a long-acting progestogen, levonorgestrel butanoate, combined with a long-acting androgen, testosterone buciclate, can suppress spermatogenesis: ii. efficacy study.two combined injections of levonorgestrel butanoate (4 mg/kg) and testosterone buciclate (8 mg/kg) at 3-month intervals to adult male baboons initiated a decrease in sperm concentration from baseline values of 490x10(6)/ml to minimum values of 17x10(6/ml. this suppression was sustained until week 32, during which time between one and three azoospermic samples were collected from each of four out of five treated baboons in the period 10-24 weeks. circulating plasma levels of lh and testosterone d ...19957665214
brainstem auditory evoked response development in preterm and term baboons (papio hamadryas).brainstem auditory evoked responses were recorded longitudinally from 11 neonatal baboons (papio hamadryas), 6 of which were preterm. recordings were made in unsedated animals from day 161 to day 362 after conception (term = 182 days). the pattern of development of both waveform morphology and of wave latency was consistent with that seen in the human neonate, with a rapid maturation of the response during the perinatal period, and then a slower development to adult values. brainstem conduction ...19947842507
[spontaneous coronavirus infection in monkeys].a high level of the spread of coronavirus (cv) infection among hamadryas baboons and macaques of different species (about 50%), both resident in the animal house and imported, has been established. the tropism of cv to the gastrointestinal and respiratory tracts has been demonstrated. the course of spontaneous cv infection is accompanied by enterocolitis and/or pneumonia with periodic exacerbations, or takes the inapparent form. cases of virus persistence have also been noted. infected macaques ...19947856336
observations on the ascending aortic fold in two chacma baboons (papio hamadryas ursinus).baboons (papio) were used to study the ascending aortic fold. the fold was present in two out of 20 hearts examined. its position and shape was comparable to that observed in human subjects. the principal difference was the absence of paraganglia. the functional role of the baboon fold is unclear.19947897641
[a new variant of the simian t-lymphotropic retrovirus type i (stlv-if) in the sukhumi colony of hamadryas baboons].polymerase chain reaction (pcr) was developed for the detection of simian t-lymphotropic virus type 1 (stlv-1) infection of p. hamadryas and direct sequencing using oligo-nucleotide primer pairs specific for the tax and env regions of the related human t-lymphotropic virus type 1 (htlv-1). excellent specificity was shown in the detection of stlv-1 provirus in infected baboons by pcr using htlv-1-derived primers. the nucleotide sequences of env 467bp and tax 159bp of the proviral genome (env posi ...19937905690
a primate t-lymphotropic virus, ptlv-l, different from human t-lymphotropic viruses types i and ii, in a wild-caught baboon (papio hamadryas).searching for clues to the evolution of the primate t-lymphotropic viruses (ptlvs), which include the human and the simian t-lymphotropic viruses (htlv and stlv), we have identified another ptlv, which differs sufficiently from the known ptlv-i and ptlv-ii types to be designated here ptlv-l. the virus was isolated from a wild-born baboon (papio hamadryas) from eritrea. in a cdna library a 1802-bp-long fragment was identified that extends from the env region, including the complete transmembrane ...19947908445
recombinant growth hormone and insulin-like growth factor i do not alter gonadotrophin stimulation of the baboon testis in vivo.in vitro studies indicate a physiological role for insulin-like growth factor i (igf-i) in paracrine regulation of testicular function and recent clinical studies suggest a potential role for growth hormone (gh) and/or igf-i in the treatment of hypogonadotrophic states in males. this study aimed to examine the effects of pretreatment with recombinant human gh (rhgh) or rhigf-i on the response to gonadotrophins of the non-human primate testis in vivo. using a balanced latin square design with rep ...19947921230
[the immunological efficacy of francisella tularensis outer membranes for hamadryas baboons].the protective properties of the preparation of f. tularensis outer membranes (om), obtained from f. tularensis vaccine strain 15, were studied in experiments on hamadryas baboons challenged subcutaneously with f. tularensis virulent strain schu (nonarctic subspecies). the subcutaneous immunization with the om preparation prevented the development of clinically pronounced infection in more than 70% of the monkeys challenged with f. tularensis strain schu in a dose of 787 live microbial cells 30 ...19947941871
temporal organisation of action in baboons: comparisons with the temporal segmentation in chimpanzee and human behaviour.the durations of sequences of functionally related movements, or action units, were analysed in the baboons papio hamadryas and papio anubis. action units are completed within a narrow time span or temporal segment as found previously in pongids and humans. although the temporal segmentation is generally similar in the three species, baboons show several differences from both chimpanzees and humans. firstly, their temporal segments are shorter and less variable and the different sorts of action ...19947953607
infection of a yellow baboon with simian immunodeficiency virus from african green monkeys: evidence for cross-species transmission in the wild.many african primates are known to be naturally infected with simian immunodeficiency viruses (sivs), but only a fraction of these viruses has been molecularly characterized. one primate species for which only serological evidence of siv infection has been reported is the yellow baboon (papio hamadryas cynocephalus). two wild-living baboons with strong sivagm seroreactivity were previously identified in a tanzanian national park where baboons and african green monkeys shared the same habitat (t. ...19947966642
helminthic infestation complicated by intussusception in baboons (papio hamadryas).two juvenile baboons presented with diarrhoea, which did not resolve completely following antibiotic therapy. ileal intussusception was identified at autopsy in both cases. trichuris was the only gastrointestinal pathogen for which evidence could be found. this helminth is well-recognized as a cause of intussusception in human infants, but the complication has not been reported previously in non-human primates. it is likely to be fatal if undiagnosed.19947967467
[the evaluation in hamadryas baboons of the possibility for the specific prevention of ebola fever].the protective role of virus-neutralizing antibody was demonstrated in ebola virus-infected animals (papio hamadryas) used in experiments on the development of passive humoral immunity by using specific immunoglobulin. two immunizations of the monkeys with purified concentrated ebola virus antigen with complete freund adjuvant was shown to confirm intensive immunity to subsequent challenge protecting 80% of the immunized animals. it is concluded that effective preparations may be developed for s ...19948017061
baboon and cotton-top tamarin b2m cdna sequences and the evolution of primate beta 2-microglobulin.nonhuman primates represent phylogenetic intermediates for studying the divergence of human and murine beta 2ms. we report the nucleotide sequences of b2m cdna clones from a baboon cell line, 26cb-1 (papio hamadryas; primates: cercopithecoidea), and a cotton-top tamarin cell line, 1605l (saguinus oedipus; primates: ceboidea). the baboon and tamarin b2m sequences indicate a very slow rate of b2m evolution in primates relative to that in murid rodents. phenotypic evolution of beta 2m has also been ...19948026986
[the properties of simian coronavirus].properties of 20 coronavirus (cv) isolates obtained from spontaneously infected papio hamadryas and rhesus monkeys were investigated. two of them were selected as simian cv prototype strains-cvrm 281 (rhesus monkey) and cvp 250 (papio hamadryas), and can be offered as candidates to the coronaviridae family. they are closely related to each other, but differ in some biological properties and polypeptides. these strains belong to the 2nd antigen group of mammalian cv with the prototype strain hcv ...19938073751
nuclear dna polymorphisms in a wild population of yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania.yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania were studied for polymorphisms in nuclear dna. the study population consists of four social groups that inhabit overlapping home ranges and exchange males. as a result, these groups are considered to be members of a single interbreeding population. human dna clones were used as probes to screen five loci (at3, ren, hexb, vim, and apob) for restriction fragment length polymorphisms (rflp). a total of 14 polymorphism ...19938097371
[the effect of psychotropic preparations on the behavioral and hormonal manifestations of emotional stress in monkeys].ethological and radioimmunological techniques were used to examine the effects of psychotropic agents on the behaviour of the male papio hamadryas and the hormonal activity of the steroid-producing glands at physiological rest and during emotional stress. prior (15 minutes before immobilization) intramuscular administration of haloperidol, 0.1 mg/kg, amitriptyline, 2.0 mg/kg or diazepam, 0.76 mg/kg, was demonstrated to produce no stress protective effect, but to result in predominant effects of ...19938220002
a primate model of monotypism in atherosclerotic lesions.we have characterized the expression of allelic variants of x-linked glucose 6-phosphate dehydrogenase (g6pd) in aorta from homozygous, hemizygous, and heterozygous baboons (papio hamadryas). fibrous plaques from heterozygous baboons fed a high cholesterol, saturated fat diet contained distributions of g6pd allelic variants that differed from those of normal arterial wall and fatty streaks. the skewed allelic expression patterns in fibrous plaques of heterozygotes reflect decreased cellular hete ...19938224112
[a trial to produce an inactivated lassa fever vaccine].a single and double immunization of papio hamadryas monkeys with an inactivated concentrated purified adsorbed preparation of lassa virus in doses of 0.5-1.0 and 1.1-2.1 mg by protein, respectively, protected the animals against the development of the disease and occurrence of viremia after an intramuscular challenge with 0.4 pfu dose. upon aerogenic infection of monkeys protection of 50% of the animals was achieved by a single immunization with the inactivated preparation in a dose 1.1 mg by pr ...19938303891
the sukhumi primate monkey model for viral lymphomogenesis: high incidence of lymphomas with presence of stlv-i and ebv-like virus.t-cell leukemia virus-like proviral sequences (stlv-i) as well as ebv-like sequences were detected in pbls and tissues of non-human primates (papio hamadryas baboons, green monkeys and macaca arctoides; sukhumi primate center/georgia) by pcr. surprisingly, two different types of stlv-i within papio hamadryas baboons were found. one of its represents the baboon prototype stlv-i-su described earlier, present in lymphomatous baboons from the "high-lymphoma stock", which shows about 83% homology to ...19938395624
corticotropin-releasing hormone in baboon pregnancy.during human pregnancy, plasma crh immunoreactivity (crh-ir) rises progressively, peaking during labor and falling after delivery. among animal species, only higher primates have elevated crh-ir during pregnancy. this study examines whether changes in plasma crh-ir in the baboon (papio hamadryas) are similar to those in the human. crh-ir was determined by ria in 16 baboons at different stages of gestation (44 samples) and in 3 males. assays were performed on vycor extracts of plasma and crh-ir d ...19938473382
linkage mapping in papio baboons: conservation of a syntenic group of six markers on human chromosome 1.we have established multipoint genetic linkage among six loci in baboons (papio hamadryas). published pcr primers designed to amplify five human microsatellite loci were used to amplify homologous loci in 229 pedigreed baboons. southern blotting was used to type two rflps in a functional gene (anti-thrombin iii) in a subset of those animals. all six loci are known to map to human chromosome 1q, a region of the genome predicted by karyotype studies to be conserved in baboons. pairwise recombinati ...19958530033
zoonotic intestinal parasites of hamadryas baboons papio hamadryas in the western and northern regions of saudi arabia.six hundred and thirty-three faecal samples were randomly collected and examined for ova and cysts of intestinal parasites from five groups of hamadryas baboons of different population densities, with different human contact and in different ecological conditions (al-baha, turabah and al-taif in south-western and al-rihat and al-akhal in north-western saudi arabia). nine parasites were recorded (giardia lamblia, entamoeba histolytica, escherichia coli, balantidium coli, enterobius sp., trichuris ...19958544227
failure of experimental infection of baboons (papio hamadryas) with the eggs of asian taenia.the infectivity of the eggs of asian taenia sp. for humans is not known. using baboons (papio hamadryas) as a model to extrapolate the findings, three animals were exposed per os with 1000, 10,000 and 50,000 infective eggs of the asian taenia sp. the serological, biochemical, haematological and parasitological (based on necropsy) results show that baboons are refractory to the infection. it is concluded that the asian taeniid eggs may fail to develop in man.19958583131
the presence of a divergent t-lymphotropic virus in a wild-caught pygmy chimpanzee (pan paniscus) supports an african origin for the human t-lymphotropic/simian t-lymphotropic group of viruses.we isolated a divergent simian t-lymphotropic virus (stlv) (strain pp1664) from a wild-caught african bonobo (pygmy chimpanzee, pan paniscus). molecular and phylogenetic characterization of this virus show that it reliably separates from the two well-established primate t-lymphotropic virus types, htlv-i/stlv-i (ptlv-i) and ptlv-ii, and from a third type isolated from an african-born papio hamadryas and designated by us as ptlv-l. four of eight bonobos kept at the antwerp zoo, belgium, showed an ...19968609475
influence of neuropeptides on the processes of higher nervous activity in primates. the action of cyclic analogs of enkephalins on the behavior of the lower monkeys.the effect of two cyclic enkephalin analogs (ivs-43 and ivs-46) on the group and individual behavior of rhesus macaques and hamadryas baboons has been studied. a pronounced influence of ivs-46 on competitive and operant goal-directed behavior of the monkeys was identified.19958614479
the genomic structure of a new simian t-lymphotropic virus, stlv-ph969, differs from that of human t-lymphotropic virus types i and ii.a new simian t-lymphotropic virus, stlv-ph969, was recently isolated from a wild-born hamadryas baboon. previous analysis had revealed that it differs sufficiently from the other htlv/stlvs to be considered a new type, provisionally designated primate t-lymphotropic virus-l. here we analyse a 3850 bp cdna fragment spanning the 3' part of the stlv-ph969 genome. the fragment encodes three major proteins: env, tax and rex. sequence comparison and phylogenetic analysis indicate that in general stlv- ...19968627239
the three human t-lymphotropic virus type i subtypes arose from three geographically distinct simian reservoirs.to investigate the origin of human t-lymphotropic virus i (htlv-i), strains of diverse geographical origin were analysed. we sequenced the ltr and env genes of htlv-i strains from brazil, central african republic, taiwan and zaire, and the simian t-lymphotropic virus type i (stlv-i) strain phsu1 from a baboon from the sukhumi primate centre. we performed phylogenetic analyses using neighbour-joining, parsimony and maximum likelihood methods. three separate htlv-i clusters were identified intersp ...19968627240
interspecies transmission of macaque simian t-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma.an outbreak of malignant lymphoma has been observed in one of the baboon (papio hamadryas) stocks of sukhumi primate center. more than 300 cases in this "high-lymphoma stock" have been registered since 1967. human t-cell lymphotropic virus type 1 (htlv-1)-related virus was implicated as the etiologic agent of sukhumi baboon lymphoma. the origin of this virus remained unclear. two possibilities were originally considered: the origin could be baboon simian t-cell leukemia/lymphoma virus type 1 (st ...19968627684
[development and study of the properties of immunoglobulin against ebola fever].immunoglobulin to ebola fever has been for the first time prepared from hyperimmune equine blood sera by alcohol fractionation after cohn. preclinical study of the physicochemical and immunobiological properties of immunoglobulin showed that it protects up to 100% papio hamadryas infected intramuscularly at doses of 110 to 29 ld50 ebola virus. scheme for the use of ebola immunoglobulin has been experimentally validated.19958686265
comparative antigenicity of recombinant wild-type staphylokinase (sakstar) and a selected mutant (sakstar.m38) in a baboon thrombolysis model.staphylokinase, a bacterial plasminogen activator, is a potent, highly fibrin-specific but antigenic thrombolytic agent in humans. in an effort to attenuate the antigenicity of wild-type staphylokinase (sakstar variant), 2 of its 3 immunodominant epitopes were altered by substituting clusters of 2 or 3 charged amino acids with alanine, yielding the mutant sakstar.m38 (k35a, e38a, k74a, e75a, r77a), which was less antigenic in inbred new zealand white rabbits. in the present study, groups of 6 ba ...19968761847
hamadryas baboons papio hamadryas as maintenance hosts of schistosoma mansoni in saudi arabia.free ranging hamadryas baboons (papio hamadryas) in four localities in the west and north of saudi arabia were examined for natural infection with schistosoma mansoni. faecal examination revealed infection with s. mansoni on four occasions within one year (at a prevalence rate of 2.5-4.0%) in only one locality, the al-baha area. the eggs were viable, as shown by miracidial hatching tests, and were recorded at a density of 140-280 eggs/g of faeces (7000-14,000 eggs/day). post-mortem examination o ...19968765452
questions on the evolution of primate t-lymphotropic viruses raised by molecular and epidemiological studies of divergent strains.in human and simian t-lymphotropic viruses (htlv and stlv), collectively referred to as primate t-lymphotropic viruses (ptlv), four distinct clades can be distinguished: ptlv-i, ptlv-ii, and the newly discovered divergent stlvs isolated from hamadryas baboons and from bonobos (pygmy chimpanzees). the hamadryas stlv is clearly distinct from types i and ii, in terms both of sequence divergence and of genomic structure, and would qualify as a separate type, provisionally called ptlv-l. the bonobo s ...19968797730
a comparison of tspy genes from y-chromosomal dna of the great apes and humans: sequence, evolution, and phylogeny.the genes for testis-specific protein y (tspy) were sequenced from chimpanzee (pan troglodytes), gorilla (gorilla gorilla), orangutan (pongo pygmaeus), and baboon (papio hamadryas). the sequences were compared with each other and with the published human sequence. substitutions were detected at 144 of the 755 nucleotide positions compared. in overviewing five sequences, one deletion in human, four successive nucleotide insertions in orangutan, and seven deletions/insertions in baboon sequence we ...19968798990
phylogenetic characterization of simian t lymphotropic virus type i (stlv-i) from the ethiopian sacred baboon (papio hamadryas). 19968835205
molecular features of the tspy gene of gibbons and old world monkeys.restriction pattern, chromosome localization and the sequence of the testis-specific gene, tspy, were investigated in the white-handed gibbon, agile gibbon, siamang, hamadryas baboon and japanese monkey. southern blot analysis showed the tspy gene to be male specific in the primates used and disclosed variability of restriction pattern in gibbons. fluorescence in situ hybridization demonstrated that the probe pptspy2372, biotinylated using polymerase chain reaction, is located as a slight signal ...19968939361
organization of the epaxial muscles in terrestrial and arboreal primates.the erector spinae muscles of the patas monkey hamadryas baboon, and spider monkey were dissected and the origins and insertions were described in detail. in the two terrestrial monkeys, a well-developed thoracolumbar segment of the muscle was observed. this trait seems to correlate to the sagittal movement of this region required in the pronograde quadrupedal locomotion. on the other hand, the erector spinae muscle of the spider monkey is quantitatively not so well developed and the arrangement ...19968953747
fetal ultrasonography: normal biometric ranges in the baboon (papio hamadryas).normal biometric ranges for fetal growth in a captive breeding baboon (papio hamadryas) colony are described. measurements include crownrump length, biparietal diameter, binocular distance, head circumference, abdominal circumference, femur length and amniotic fluid index. the pattern of fetal growth is compared with other baboon subspecies and man. the uses and limitations of such data for breeding colony management and optimum utilisation of experimentally derived data are discussed.19969029398
precision grips, hand morphology, and tools.this study asks whether there are discernable links between precision gripping, tool behaviors, and hand morphology in modern hominoids, which may guide functional interpretation of early hominid hand morphology. findings from a three-pronged investigation answer this question in the affirmative, as follows: (1) experimental manufacture of early prehistoric tools provides evidence of connections between distinctive human precision grips and effective tool making. (a connection is not found betwe ...19979034041
conservation of human chromosome 18 in baboons (papio hamadryas): a linkage map of eight human microsatellites.a panel of 25 microsatellite loci known to map to human chromosome 18 was screened for length polymorphisms in a multigenerational pedigree of baboons (papio hamadryas). eight of these loci were polymorphic in the baboon pedigrees, with observed heterozygosity values ranging from 0.16 to 0.88. all eight loci show strong evidence of linkage. the most likely map order among the microsatellite loci for papio is completely compatible with the locus order found in the human genome, and sex difference ...19969067425
simian t-lymphotropic virus type 1 (stlv-1) infection in wild yellow baboons (papio hamadryas cynocephalus) from mikumi national park, tanzania.serum and peripheral blood leukocytes from wild yellow baboons (papio hamadryas cynocephalus) were tested for the presence of stlv-1-specific antibodies and proviral dna. fourteen of 30 sera tested positive by radioimmunoprecipitation assay (ripa) with htlv-1. among 36 dna samples tested by pcr 15 were positive by double nested pcr for a fragment of the stlv-1 env gene, the most sensitive assay among pcr tests employed. of 30 animals that were tested both serologically and by pcr in only 1 case ...19979123842
[morpho-immunologic phenotypes of t-cell non-hodgkin's malignant lymphoma in baboons and their connection with with t-lymphotropic retrovirus stlv-1].8 cytological types were detected among 58 cases of t-nhl of papio hamadryas according to human updated kiel classification (1988). 5 of them were of low grade (lymphocytic, prolymphocytic, t-zone, angioimmunoblastic, small cell pleomorphic) and 3-of high grade (medium and large cell pleomorphic, immunoblastic, large cell anaplastic cd30/ki-1+). there are differences in a tumor structure and generalization in baboon and human lymphomas in spite of significant similarities. stlv-1 presence (antib ...19979139601
[preparation and characteristics of cultured strains of hepatitis a virus from humans and monkeys].cultural strains of hepatitis a virus (hav) have been isolated from spontaneously infected macaca mulatta (hav-mm), papio hamadryas (hav-ph), african green monkeys cercopithecus aethiops (hav-ca), and patients (hav-h). the strains replicate in continuous cells lines agmk, 4647, vero, and frhk-4. agmk and 4647 cells are the most permissive at 32 degrees c. virus propagation was not associated with the cytopathic effect and could be detected by enzyme immunoassay (eia), immune electron microscopy ...19979182400
complete nucleotide sequence of the new simian t-lymphotropic virus, stlv-ph969 from a hamadryas baboon, and unusual features of its long terminal repeat.a third type of primate t-lymphotropic virus, ptlv-l, with stlv-ph969 as a prototype, has recently been isolated from an african baboon (papio hamadryas). classification of this virus has been based on partial sequence analysis of cdna from a virus-producing cell line, ph969. we obtained the complete nucleotide sequence of this virus with a proviral genome of 8,916 bp. all major genes, homologous in all human t-cell lymphotropic virus (htlv)-related viruses, and their corresponding mrnas, includ ...19979188619
[quantitative patterns in the clinical manifestations of radiation sickness in large laboratory animals exposed to radiation at superlethal doses. the quantitative patterns in the manifestations of radiation sickness in monkeys].radiation sickness manifestations have been studied in two species (macaca fascicularis and papio hamadryas) exposed to electron and gamma-neutron radiations in a wide supralethal doses range. dose-response relationships have been calculated for mortality and some clinical manifestations of the intestinal and cerebral forms of radiation sickness. higher radiosensitivity of baboons in comparison with macaca fascicularis and clinically more dangerous damage due to electrons as compared to gamma-ne ...19979244532
[follow-up study of the evolution of the quantitative eeg in intraventricular infusion of nerve growth factor in an aged baboon].the animal model of aged monkeys is a good homologue of alzheimer's disease in humans, in which it has been shown that there is disproportionate slowing of the eeg when compared with healthy subjects paired for age. this is found both on the conventional eeg and quantitatively. in the latter, relative energy has been the measurement most commonly used for diagnosis and follow-up with various treatments. the follow-up parameters evaluated in this study were: absolute and relative energy of the qu ...19979244612
[study of the effectiveness of recombinant alpha2-interferon and its inducers in primates with orthopoxvirus infection].the interferon-inducing and antiviral activities of high-molecular interferon inducers larifan and rifastin and of gene engineering human alpha 2-interferon were studied in monkeys infected with smallpox. these agents appreciably prolonged the life span of infected monkeys. for green monkeys the drug efficacies were as follows: larifan protected 50%, rifastin 86%, and realderon 50% (if used for treatment) and 80% (if used for urgent prophylaxis) of animals from death; for papio hamadryas the eff ...19979304302
androgen effects on bioactive and immunoreactive gonadotrophin levels during puberty in male baboons.the effect of androgens on changes in circulating lh and fsh during pubertal development was examined longitudinally in a 3 year study in male hamadryas baboons. baboon lh and fsh were measured by a species-specific radioimmunoassay and bioactive lh (b-lh) was measured by the mouse in vitro leydig cell bioassay. control baboons (n = 5) progressed normally through puberty. eight baboons were castrated prepubertally; of these four received testosterone implants at the chronological age (ca) of cli ...19979364367
growth and hormone characteristics of pubertal development in the hamadryas baboon.the semi-longitudinal collection of growth measurements in male and female hamadryas baboons has enabled documentation of the timing of puberty and the development of sexually dimorphic growth patterns in body weight, crown-rump length (crl), limb lengths, and muscle mass. in addition, another sexually dimorphic characteristic appears to be the presence of a pubertal growth spurt in body weight, and possibly crl, in male but not female baboons. serum testosterone levels rose during male developm ...19979379482
isolation of mycobacterium bovis from baboons, leopards and a sea-lion.this study reports on two series of cases of mycobacterium bovis infection in zoo animals. the first was in a captive population of baboons (papio hamadryas) and the second in a mixed group of wild mammals, including four leopards (panthera uncia and panthera pardus) and a sea-lion (otaria byrona). the isolation and identification of strains of m. bovis confirmed the presence of m. bovis infections in both zoos. the epidemiological study using genetic markers such as the is6110-based dna fingerp ...19989601152
[characteristics of experimental models of hepatitis a in papio hamadryas].hepatitis a (ha) was induced in 14 papio hamadryas by strain vha-ph isolated from this species of monkeys with spontaneous infection, strain vha-mm isolated from macaca mulatta, and a unique strain vha-h3 isolated from a patient; this latter strain is pathogenic for macaca mulatta in experiment. all infected seronegative animals developed a disease with virological, serological, biochemical, and morphological signs characteristic of human ha, but the duration of these signs manifestation varied. ...19989606873
astroglial interlaminar processes in the cerebral cortex of prosimians and old world monkeys.previous observations have shown that astrocytes with interlaminar processes are present in the cerebral cortex of humans and new and old world monkeys, but not in the rodent. the present report furthers the analysis of possible evolutionary aspects regarding the expression of such astroglial features. a comparison between young and adult microcebus murinus, a prosimian, and old world monkeys (macaca mulatta and papio hamadryas) is presented. brain samples were processed for glial fibrillary aci ...19989623670
evolution of the primate androgen receptor: a structural basis for disease.androgen effects mediated by the androgen receptor (ar) are essential for male reproductive development and virilization. comparison of ar dna coding sequence from five primate species, homo sapiens (human), pan troglodytes (chimpanzee), papio hamadryas (baboon), macaca fascicularis (macaque), and eulemur fulvus collaris (collared brown lemur), supports their phylogeny with complete conservation of the dna and steroid binding domain protein sequence. a linear increase in trinucleotide repeat exp ...19989732460
baboon/human homologies examined by spectral karyotyping (sky): a visual comparison.baboon (papio hamadryas) metaphase chromosomes were analyzed using spectral karyotyping (sky), a technique combining fluorescence microscopy, ccd-imaging, and fourier spectroscopy. results from a comparison of sky analyses using probes derived from human chromosomes on baboon metaphases were consistent with the majority of comparative gene mapping data between the two species. these data were also compatible with earlier studies comparing macaque and human chromosomes. human (hsa) chromosome 2 w ...19989763666
imaging dopamine d4 receptors in the living primate brain: a positron emission tomography study using the novel d1/d4 antagonist [11c]sdz glc 756.the dopamine d4 receptor has lately attracted interest since it has been hypothesized to be involved in the pathogenesis and pharmacotherapy of neuropsychiatric diseases. the present study provides first in vivo evidence of dopamine d4 receptors in primate brain using a [11c]benzo[g]quinoline, the novel radioligand [11c]sdz glc 756 ([11c]glc: in vitro dissociation constants at human receptor clones [nm]: 1.10 at d1; 0.40 at d2; 25 at d3; 0.18 at d4.2; 6.03 at d5). dynamic positron emission tomog ...19989826226
teratoma with trisomy 16 in a baboon (papio hamadryas).a teratoma was found during a planned cesarean section in a 10-year-old primigravida baboon. this teratoma had a female sex chromosome complement and trisomy for chromosome 16. this is the first report of a teratoma in a baboon and the first report of a chromosomal abnormality in a nonhuman primate teratoma. it is also the first case in a nonhuman primate to address the mechanism of origin. through the use of genetic markers from human chromosomes 5, 8 and 17, the origin of the teratoma was show ...19989839905
identification of evolutionarily invariant sequences in the protein c gene promoter.recent studies on human protein c gene expression have revealed the presence of three transcription factor binding sites in close proximity to the transcription start site. binding sites for the liver-enriched hepatocyte nuclear factors 1 and 3 (hnf-1 and hnf-3, respectively) are located immediately upstream of the transcription start site, whereas just downstream of the start site a presently unidentified transcription factor may bind. to identify other candidate transcription factor binding si ...19989847407
molecular timing of primate divergences as estimated by two nonprimate calibration points.the complete mitochondrial dna (mtdna) molecule of the hamadryas baboon, papio hamadryas, was sequenced and included in a molecular analysis of 24 complete mammalian mtdnas. the particular aim of the study was to time the divergence between cercopithecoidea and hominoidea. that divergence, set at 30 million years before present (mybp) was a fundamental reference for the original proposal of recent hominoid divergences, according to which the split among gorilla, chimpanzee, and homo took place 5 ...19989847414
verreaux's eagles (aquila verreauxi) as potential predators of hamadryas baboons (papio hamadryas hamadryas) in eritrea.in this paper we describe for the first time encounters of verreaux's eagle (aquila verreauxi) with hamadryas baboons (papio hamadryas hamadryas) in the central highlands of eritrea (15 degrees 22' n, 38 degrees 58' e, 2300 m). during 12 h of observation on 4 days, we observed four encounters of verreaux's eagles with baboons, of which three can be classified as possible attacks. the baboons always responded with alarm calls. in three cases some immatures rushed to adult group members and clung ...19999888722
[growing divergence inside primate t cell lymphotropic viruses].during our studies on the evolution of the ptlvs, we have isolated and genomically characterized two divergent simian t-lymphotropic viruses, not belonging to the previously well-established ptlv lineages. stlv-ph969 has been isolated from an eritrean sacred baboon (papio hamadryas), with an htlv-like indeterminate serological profile. the entire 8916 nt long genomic sequence, was obtained from a cdna library of ph969 mrna, in combination with a pcr based strategy. all open reading frames (orf) ...199910379197
histopathological and parasitological changes in baboons (papio hamadryas) experimentally infected with baboon and human isolates of schistosoma mansoni from saudi arabia: a comparative study. 199910474648
the discovery of two new divergent stlvs has implications for the evolution and epidemiology of htlvs.we have isolated and characterised two divergent simian t-lymphotropic viruses (stlv), not belonging to the established human and simian t-lymphotropic virus lineages htlv-1/stlv-1 and htlv-2. stlv-l, from an eritrean sacred baboon (papio hamadryas), has been typed as a third type of simian t-lymphotropic virus, distinct from htlv-1/stlv-1 and htlv-2. the other virus, isolated from congolese bonobos (pan paniscus), is a distinct member of the htlv-2 clade and has been designated stlv-2. the isol ...199910479777
new world, but not old world, monkeys carry several genes encoding beta-microseminoprotein.it was shown by southern hybridization that cotton-top tamarin and common marmoset, new world monkeys, carry three or more genes encoding beta-microseminoprotein, also known as psp94. in contrast, the genomes of old world monkeys, as represented by rhesus macaque and sacred baboon, contain a single gene. clones containing three different genes encoding beta-microseminoprotein were isolated from a cotton-top tamarin genomic library. they carry two complete genes of four exons and a third gene lac ...199910491085
low-dose nitro-l-arginine administration in baboon (papio hamadryas) pregnancy.1. the purpose of the present study was to examine the effect of nitric oxide (no) inhibition on mean arterial pressure (map), endothelin (et) and the renin-aldosterone system in pregnancy in the non-human primate (baboon). 2. twenty pregnant baboons (papio hamadryas) were examined prospectively after the administration of an oral no inhibitor in different phases of pregnancy. haemodynamic responses to no inhibition, evidence of pre-eclampsia and the renin-aldosterone system were examined under ...199910561803
molecular phylogeny of old world monkeys (cercopithecidae) as inferred from gamma-globin dna sequences.dna sequence data of the nuclear-encoded gamma1-gamma2-globin duplication region were used to examine the phylogenetic relationships of 16 cercopithecid (old world monkey) species representing 12 extant genera. morphology- and molecular-based hypotheses of old world monkey branching patterns are generally congruent, except for generic relationships within the subtribe papionina. the cercopithecids divide into colobines (leaf-eating monkeys) and cercopithecines (cheek-pouched monkeys). the colobi ...199910603263
"rodent-like" and "primate-like" types of astroglial architecture in the adult cerebral cortex of mammals: a comparative study.previous observations disclosed that astroglia with interlaminar processes were present in the cerebral cortex of adult new and old world monkeys, but not in the rat, and scarcely in the prosimian microcebus murinus. the present report is a more systematic and comprehensive comparative analysis of the occurrence of such processes in the cerebral cortex of several mammalian species. brain samples were obtained from adult individuals from the following orders: carnivora (canine), rodentia (rat and ...200010672363
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