| formaldehyde formation as a metabolite of methoxyflurane. | the production of formaldehyde as a metabolite of enzymatic biotransformation of methoxyflurane was observed in vitro in hepatic microsomal preparations derived from japanese monkeys, rabbits and wistar strain rats. production rates of formaldehyde were 0.80-2.50 n moles/mg protein/min in the induced group which was pretreated with phenobarbitone, and 0.15-0.68 n moles/mg protein/min in the non-induced group. this reaction needed the presence of nadph and oxygen. formaldehyde production was almo ... | 1977 | 16507 |
| purification and characterization of arylamidase from monkey brain. | arylamidase ec3.4.11.2 was isolated from monkey brain extract and purified about 2100-fold in approximately 11% yield by a six-step procedure comprising extraction from monkey brain homogenate, ammonium sulfate fractionation, first hydroxylapatite chromatography, deae-cellulose chromatography, sephadex g-200 gell filtration and second hydroxylapatite chromatography. the enzyme showed a single band on polyacrylamide disc electrophoresis and consisted of a single polypeptide chain, as judged by di ... | 1977 | 16872 |
| the effects of beta adrenergic blockade on spinal cord autoregulation in the monkey. | blood flow in the spinal cord was measured in a group of monkeys over a wide range of artificially varied blood pressures after the administration of propranolol, a beta adrenergic blocker. spinal cord blood flow was found to be constant and in the normal range between a mean system arterial blood pressure of 50 to 150 mm hg. from 150 to 180 mm hg spinal cord blood flow decreased. there was no breakthrough of autoregulation, previously seen in the untreated animal. it is suggested, therefore, th ... | 1977 | 16991 |
| bone marrow transplantation. | improvements in the results of bone marrow transplantation for the treatment of scid may be expected by employing purified stem-cell concentrates for patients who do not have a compatible sibling available. refinements in the purification technique and its monitoring are required, however. for the same category of patients it seems worthwhile to continue attempts at restoration with liver cells from fetuses less than 12 weeks of age. in addition, full protection against infections should be prov ... | 1977 | 17188 |
| role of normal cell antigens in the establishment of measles virus in newborn white mice. | the edmontson strain of measles virus was adapted to the brains of newborn white mice to which extracts from african green monkey kidney (vero) cells used for maintenance of measles virus had been injected intracerebrally. the animals showed symptoms of involvement of the central nervous system (pareses, paralyses) which reappeared in subsequent passages. | 1977 | 17289 |
| absorption, excretion and disposition of cyclindole in laboratory animals and human volunteers. | radioactivity from orally administered single doses of cyclindole-14c was excreted primarily in the urine of the rat (99%/48 hr), monkey (80%/120 hr), and dog (70%/144 hr). approximately 38-58% of a daily dose of cyclindole was recovered from 24-hr human urine, as determined by gas chromatography. substantial amounts of unchanged drug were voided by dogs. cyclindole was metabolized primarily by n-demethylation and/or hydroxylation in the 7-position. hydroxylation at the 6-carbon atom was of mino ... | 1977 | 17521 |
| an analysis of factors influencing the isolation rate of herpes simplex virus. | attempts were made to improve the rate of isolation of herpes simplex virus (hsv) from clinical specimens by minimizing loss of virus infectivity during transportation and employing the most sensitive cells for isolation. basical analyses using standard strains of type 1 and type 2 hsv indicated that virus titer decrease was marked even at low temperatures in environments free of proteinous stabilizer such as normal serum or tissue extract, negating the generally held concept that hsv is stable ... | 1977 | 17816 |
| colour coding in the superior temporal sulcus of rhesus monkey visual cortex. | | 1977 | 17866 |
| effects upon the fetus of oxygen administration to the mother. a study in monkey. | catheters were placed into assorted arteries and veins of 8 anaesthetized pregnant monkeys and their fetuses. oxygen-sensitive electrodes were also inserted subcutaneously into 3 of the 8 fetuses. periodic samples of maternal and fetal blood were analyzed for po2, pco2 and ph. oxygen administration to the mothers reliably increased the po2 of blood taken from the fetal carotid artery and less constantly augmented the po2 of blood withdrawn from the femoral artery and vein. during 5-6 hours of st ... | 1977 | 17994 |
| variation in age at puberty in monkeys. | 5 female and 3 male patas monkeys and 6 female and 3 male talapoin monkeys matured in a captive breeding colony. age at puberty is given, and some variation discussed. the talapoin, a very small monkey, becomes adult at 4 1/2 years for females, 1 or 2 years later for males. the patas, a rather large monkey, becomes adult at 2 1/2 years, for females, and 1 or 2 years later for males. both these ages for puberty differ from data for the rhesus monkey which has been accepted as generalizable to all ... | 1977 | 18386 |
| testosterone production and metabolism in laboratory-maintained male rhesus monkeys. | plasma production rates (pr), metabolic clearance rates (mcr) and plasma levels of testosterone were determined in 10 male, laboratory-maintained rhesus monkeys on two occasions out-of-season (april and august) and once in-season (october). plasma testosterone levels in october were higher than those in april and august. the plasma pr was unchanged in august, but markedly increased in october, as compared to april. the mcr showed a parallel increase betueen august and october. thus changes in te ... | 1977 | 18415 |
| epizootiology, transmission and approach to prevention of fatal simian haemorrhagic fever in rhesus monkeys. | | 1977 | 18679 |
| histamine2--receptor blockade with cimetidine in the monkey cranial circulation. | | 1976 | 18733 |
| normal and abnormal middle ear ventilation. | studies in infants and children have suggested a functional rather than mechanical obstruction of the eustachian tube as a predisposing factor in middle ear effusions (mee). to simulate this condition in the laboratory, an animal model was prepared using juvenile rhesus monkeys. the tensor veli palatini muscle was transected or expunged posterior to the hamulus of the medial pterygoid lamina. transection of the muscle resulted in negative middle ear pressure without effusion, whereas when the mu ... | 1977 | 18977 |
| the metabolism of p-methoxyamphetamine in dog and monkey. o-demethylation as a major route. | p-hydroxyamphetamine (pha) and p-hydroxybenzoic acid (phba) have been isolated by gas-liquid chromatography (gc) as urinary metabolites of p-methoxyamphetamine (pma) in dogs and rhesus monkeys. the amounts of pma excreted unchanged in the total 24-hr urine samples in dogs and monkeys were 26% and 3%, respectively, of the total administered doses. the amounts of the pharmacologically active metabolite pha excreted in 24-hr urine samples were 13% in the dog and 44% in the monkey. in the dog, 72% o ... | 1977 | 19212 |
| hydrogen ion and carbon dioxide content of the oviductal fluid of the rhesus monkey (macaca mulatta). | the ph in the oviduct lumen of adult female rhesus monkey (macaca mulatta) during the menstrual cycle was measured by means of miniaturized ph electrodes. two types were used: one was a flexible electrode 1.4 mm in diameter; the other was a rigid electrode 0.8 mm in diameter. the same results were obtained with both types. for pco2 measurements, the ph electrodes was converted to a severinghaus tyep electrode covered with a teflon membrane. during the follicular phase, the ph remains constant in ... | 1977 | 19307 |
| immune responses during measles infection in immunosuppressed rhesus monkeys. | rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (atg) were infected with measles and simultaneously inoculated with sheep erythrocytes (srbc), a thymus-dependent antigen, and with pneumococcal polysaccaride type iii (sss-iii), a thymus-independent antigen. atg treatment alone suppressed srbc antibody production, had no effect on sss-iii antibody production, and effectively eliminated circulating t cells compared to nonsuppressed monkeys. atg treatment of measles-in ... | 1977 | 19536 |
| synthesis and stereospecific antipsychotic activity of (-)-1-cyclopropylmethyl-4-(3-trifluoromethylthio-5h-dibenzoa,dcyclohepten-5-ylidene)piperidine. | the synthesis and resolution of 3-iodocyproheptadine (+/-)-5a and 1-cyclopropylmethyl-4-(3-iodo-5h-dibenzo-a,dcyclohepten-5-ylidene)piperidine (+/-)-5b are described. the resulting atropisomers undergo reaction with trifluoromethylthiocopper to give optically active products without extensive racemization. in this manner, optically pure (+)- and (-)-3-trifluoromethylthiocyproheptadine (+)-6a and (-)-6a, respectively and (+)- and (-)-1-cyclopropylmethyl-4-(3-trifluoromethylthio-5h-dibenzoa,dcyclo ... | 1977 | 19627 |
| prenatal development of the visual system in rhesus monkey. | | 1977 | 19781 |
| plasticity of ocular dominance columns in monkey striate cortex. | | 1977 | 19791 |
| an electron microscopic study of the centre-median and ventrolateral nuclei of the thalamus in the monkey. | | 1977 | 19794 |
| comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys. | thyrotropin-releasing hormone (trh), 0.1 mg/kg, i.m., significantly counteracted pentobarbital narcosis in six monkeys, but melanocyte-stimulating-hormone-release-inhibiting factor (mif), 0.1 mg/kg i.m., did not. earlier dose-response studies in unanesthetized monkeys had shown that this dose of mif stimulated motor activity; this dose of trh had shown no stimulant effect, but a higher dose depressed activity. thus, an mif dose that stimulates unanesthetized monkeys does not reverse pentobarbita ... | 1977 | 19803 |
| comparative antisecretory activity of several drugs in the gastric fistula squirrel monkey and rat. | a series of known antisecretory compounds, including glycopyrrolate, clonidine, propantheline bromide, cmn 131 (2-pyridylthiocetamide), and desmethylimipramine (dmi) were tested in the gastric fistula rat and monkey. the order of potency for inhibiting acid output was similar in both species. a general similarity exists in the responsiveness of the rat and monkey to gastric antisecretory agents. these data support the use of the squirrel monkey for assessment of gastric antisecretory activity. | 1977 | 19821 |
| two cholesterol ester hydrolases. distribution in rat tissues and in cultured human fibroblasts and monkey arterial smooth muscle cells. | hydrolytic activity against acetone-dispersed 4-14ccholesterol oleate has been assayed as a function of ph in seven parenchymal tissues, blood cells, and plasma of the rat, as well as in cultured human fibroblasts and monkey (macaca nemestrina) arterial smooth muscle cells. both acid and neutral hydrolytic activities were present in all of these except rat plasma. the ph optima were in all cases close to ph 4.5 and ph 6.8. acid activity was quite constant from tissue to tissue, while neutral act ... | 1977 | 20148 |
| the disposition of a novel pyrimidoindole, ciclazindol, in the rat and patas monkey. | | 1977 | 20289 |
| daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. | 1. catheters were inserted into the foetal carotid artery and maternal middle uterine artery and vein in twenty foetuses from fifteen sows, 91-105 days pregnant. blood samples were collected from foetal and maternal circulations for periods of 7-21 days after surgery.2. blood gas tensions, ph, packed cell volume (pcv) and the levels of glucose, fructose and lactic acid in conscious pigs were followed in foetal and maternal bloods during late pregnancy.3. foetal blood gas tensions, ph, pcv, lacti ... | 1977 | 20500 |
| rearing conditions which support or inhibit later sexual potential of laboratory-born rhesus monkeys: hypothesis and diagnostic behaviors. | | 1977 | 20534 |
| ferrier lecture. functional architecture of macaque monkey visual cortex. | | 1977 | 20635 |
| comparison of interferon-inducing activities and antiviral effects of tobacco mosaic virus, tilorone and sodium nucleinate. | endogenous interferon was produced in animals in response to the administration of tobacco mosaic virus (tmv), tilorone and sodium nucleinate. the relationship between interferon production and the kind of inducer and the route of its administration was studied. tmv was completely innocuous for macaca rhesus monkeys and mice and caused no untoward effects in humans upon peroral administration. tmv, tilorone and sodium nucleinate given per os exerted a marked protective effect in mice against tic ... | 1977 | 20769 |
| methyl alcohol poisoning. ii. development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey. | rhesus monkeys were intoxicated with methyl alcohol, using an initial dose of 2 gm/kg and subsequent doses were administered in order to maintain an attenuated and prolonged state of intoxication. arterial blood samples were drawn for methyl alcohol, formate, po2, pco2, and ph, which were monitored periodically throughout the course of the experiment. with the use of these procedures monkeys developed metabolic acidosis with the accumulation of formic acid in the blood and a corresponding decrea ... | 1977 | 20870 |
| proton magnetic resonance studies of histidines in human, rhesus monkey, and bovine carbonic anhydrases. | histidine c-2 proton resonances in rhesus monkey carbonic anhydrase b (carbonate hydro-lyase, ec 4.2.1.1) and bovine carbonic anhydrase were investigated using 270-mhz proton magnetic resonance. the results suggest that there are extensive three-dimensional homologies between the human b and rhesus b enzymes and between the human c and bovine enzymes. resonances from solvent exchangeable protons have been observed in the 11-16 ppm range in the nmr spectra of human carbonic anhydrases b and c and ... | 1977 | 20966 |
| methadone n-oxide in the rhesus monkey. | | 1977 | 21270 |
| normal acid-base status of arterial blood from the conscious, chair-restrained squirrel monkey. | normal acid-base status of arterial blood (pha =7.40, paco2=38.1 torr) was demonstrated for conscious, restrained squirrel monkeys when environmental stimuli were minimized and monkeys are habituated to experimental procedures. these results indicate the potential for using squirrel monkeys in experiments in which normal acid-base status is a significant factor. | 1977 | 21297 |
| multifocal candidiasis in a capuchin monkey (cebus apella). | candidiasis involving nasal, pharyngeal, and intestinal mucosal surfaces and a pharyngeal lymph node was demonstrated microscopically in a young adult female capuchin monkey (cebus apella) experimentally infected with schistosoma haematobium (iran strain). persistent nasal exudation and weight loss characterized the clinical disease preceding the animal's death. | 1977 | 21298 |
| effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics. | by arranging a series of psychological contingencies (unpredictability, uncontrollability, conflict), coupled with delivery of a physical stimulus (electric shock), we produced gastroduodenal mucosal lesions in 7 of 8 rhesus monkeys. the most severe conflict paradigm most consistently produced lesions across subjects. of the 30 lesions observed by endoscopy, 80% occurred near the anatomic junction of gastric body and antrum, in the antrum, or in the duodenum. lesions varied in severity from disc ... | 1977 | 21564 |
| physiologic measures of nonhuman primates during physical restraint and chemical immobilization. | the arterial acid-base balance and other selected physiologic measures of physically restrained and chemically immobilized nonhuman primates from the families callithricidae, cebidae, cercopithecidae, and pongidae were compared. the physically restrained primates had significantly lower ph, pco2, and base excess values, but they had significantly higher po2 values, rectal temperatures, and pulse and respiration rates. of 56 physically restrained primates, 30 (54%) experienced severe metabolic ac ... | 1977 | 21868 |
| type i escherichia coli pili: characterization of binding to monkey kidney cells. | we have demonstrated binding of purified pili from a strain of escherichia coli to vero cell monolayers as a model of prokaryotic-eukaryotic cell adherence. pili bound to the tissue culture in a rapid reaction that did not require enzymatic activation. attachment occurred optimally at ph 4-5 and could be inhibited by analogues of d-mannose, anti-pili antibodies, or by preincubation of tissue cells with mannose-specific plant lectins. binding remained after treatment of the monolayer with glycosi ... | 1977 | 21933 |
| in vitro biosynthesis of radioactive estradiol-17 beta, 17-glucosiduronate by rhesus monkey liver. | a method for the preparation of radioactive estradiol-17 beta, 17-glucosiduronate by incubating 3h-estradiol with rhesus monkey liver microsomal preparation in the presence of uridine diphosphoglucuronic acid is described. small but significant amounts of the conjugate were also obtained from the 150,00 pellet and cytosol fractions. the addition of nadph to the incubation media increased the yield of radioactive-estradiol-17 beta, 17-glucosiduronate perhaps by preserving the integrity of the c-1 ... | 1977 | 22146 |
| neurotransmitter-sensitive adenylate cyclase in the hypothalami of guinea-pig, rat and monkey. | | 1977 | 22390 |
| characterization of the adrenergic activity of carbuterol (sk&f 40383-a). | carbuterol is a beta-adrenergic bronchodilator with selectivity for bronchial smooth muscle relative to cardiac and vascular tissues of several species including man. the present studies were undertaken to further characterize its adrenergic profile. in vitro studies demonstrated that carbuterol was a direct acting beta-adrenergic agonist, not dependent on endogenous catecholamine release, and was devoid of alpha-adrenergic agonist activity. the activity of the racemate was shown to reside prima ... | 1977 | 22441 |
| problems related to the use of serum and trypsin in the growth of monkey kidney cells. | a function of serum in the growth medium for primary monkey kidney cells has been shown to be inhibition of proteolytic enzymes. serum inactivates the residual trypsin remaining from enzymatic digestion of the kidneys and the proteolytic enzymes subsequently synthesized by the cells. freshly trypsinized cells could be grown to monolayers in the absence of serum provided that they were repeatedly washed to remove residual trypsin. in the absence of serum, cell growth ceased on the 4-5th day after ... | 1976 | 22471 |
| disseminated intravascular coagulopathy during experimental pneumococcal sepsis: studies in normal and asplenic rhesus monkeys. | disseminated intravascular coagulation (dic) was induced in both normal and asplenic rhesus monkeys by intravenous challenge with streptococcus pneumoniae. our observations in the infected monkeys have led us to conclude that (1) pneumococcal capsular polysaccharide (pcp), immune complexes and complement may not have primary roles in the initiation of dic; (2) intact pneumococci may be catalysts for the development of dic; (3) the initial event in dic may be activation of hageman factor; and (4) ... | 1977 | 22758 |
| morphology, histochemistry and isozymes of monkey kidney cells during long-term exposure to cigarette smoke. | monkey kidney cells (vero) in monolayer culture were exposed to 260 puffs of whole smoke from a mid tar range cigarette over a period of 240 days. cell morphology was investigated at the light and electron microscopic level. the histochemical characteristics of several hydrolytic enzymes and dehydrogenases were examined, and the isozymes of ldh, mdh and g6pd studied. for all these parameters smoke exposed cells displayed the same features as sham exposed and negative controls. the cells were ass ... | 1977 | 22975 |
| endotoxemia and large intestinal blood flow in subhuman primates. | the hemodynamic effects of escherichia coli endotoxin (ld80) were measured in the large intestine of anesthetized rhesus monkeys to determine whether this organ contributes to the pathogenesis of experimental shock. inferior mesenteric arterial blood flow (imf) was measured with an electromagnetic flowmeter. pressures within the aorta (ap) and portal vein (pp) were recorded. distribution of colon blood flow was measured with radioactive microspheres: ce, sr, and cr were injected into the left he ... | 1977 | 23223 |
| absorption and disposition of oxarbazole in man and laboratory animals. | oxarbazole (9-benzoyl-1,2,3,4-tetrahydro-6-methoxycarbazole-3-carboxylic acid) was absorbed by human volunteers, rats, dogs, guinea pigs, and monkeys. in all species of laboratory animals studied, the major urinary metabolite was the product of o-demethylation, 9-benzoyl-1,2,3,4-tetrahydro-6-hydroxycarbazole-3-carboxylic acid; this metabolite was conjugated in all species except the guinea pig. the dog and monkey excreted small quantities of a conjugate of 1,2,3,4-tetrahydro-6-methoxycarbazole-3 ... | 1978 | 23278 |
| response of the epididymis, ductus deferens & accessory glands of the castrated prepubertal rhesus monkey to exogenous administration of testosterone or 5alpha-dihydrotestosterone. | the response of the epididymis, ductus deferens, and accessory glands of the castrated prepubertal rhesus monkey to exogenous administration of testosterone or 5alpha-dihydrotestosterone (dht) was investigated. 200 or 800 mcg of either steroid/day were administered for 60 days beginning on the day after castration. castration caused a marked regression of the weight of and secretory function of the reproductive organs; testosterone/dht stimulated their growth and secretory activity which were ... | 1977 | 23997 |
| tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | tetramethyl benzidine (tmb) is a presumptively non-carcinogenic chromogen which yields a blue reaction-product at sites of horseradish peroxidase activity. sixty-six distinct procedures were performed in rats and monkeys in order to determine the optimal incubation parameters for tmb. as a result, a procedure is recommended whose sensitivity greatly surpasses that of a previously described benzidine dihydrochloride method. indeed, the sensitivity of this new method in demonstrating retrograde tr ... | 1978 | 24068 |
| the cortico-cortical connections to area 5 of the parietal lobe from the primary somatic sensory cortex of the monkey. | | 1978 | 24219 |
| the intrinsic connections of the primary somatic sensory cortex of the monkey. | | 1978 | 24222 |
| functional maturation of the epididymis in rabbit and rhesus monkey. | the changes in the weight, histology and biochemical composition of the epididymis (caput, corpus and cauda segments) in prepuberal rabbit and rhesus monkey in response to testosterone treatment were investigated. the increase in the weight of the organ was accompanied by increased levels of rna and dna. androgen therapy caused an increase in the concentration of sialic acid, phospholipids and glycerylphosphorylcholine and activities of alkaline phosphatase, acid phosphatase and hyaluronidase. t ... | 1977 | 24535 |
| the structure and function of acid proteases. viii. purification and characterization of cathepsins d from japanese monkey lung. | two kinds of cathepsin d were found in japanese monkey lung and were named cathepsins d-i and d-ii. cathepsin d-i was partially purified by ammonium sulfate fractionation and deae-cellulose column chromatography. it had properties common to other ordinary cathepsins d in terms of the elution position from a deae-cellulose column at ph 8.0, the ph-dependence of activity toward acid-denatured hemoglobin, and the molecular weight of 35,000 as determined by sephadex g-100 gel filtration. on the othe ... | 1978 | 24623 |
| bromocriptine, lergotrile: the antiparkinsonian efficacy and the interaction with monoaminergic receptors. | the antiparkinsonian activity of bromocriptine and of lergotrile was investigated in monkeys with surgically induced tremor and in parkinsonian patients. both drugs effectively relieve tremor in experimental monkeys and induce less pronounced abnormal involuntary movements than l-dopa or piribedil. both drugs were shown to be of therapeutic value in a group of patients with advanced parkinson's disease who were no longer responsive to levodopa combined with carbidopa. adverse effects were simila ... | 1978 | 25445 |
| metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether. | a review on metabolism and toxicity of the fluorinated anesthetic agent, fluroxene, is presented. fluroxene anesthesia is nontoxic to man but fatal to many experimental animals. the fluroxene molecule (2,2,2-trifluroethyl vinyl ether) is composed of two moieties; both are toxic as a result of their metabolism: the vinyl moiety destroys heme of cytochrome p-450 while being metabolized to the final product, co2. the trifluoroethyl moiety is oxidized to trifluoroethanol (tfe) and trifluoroacetic ac ... | 1977 | 25763 |
| purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver. | aromatic-amino-acid-glyoxylate aminotransferase was highly purified from the mitochondrial fraction of livers from monkey and glucagon-injected rats. the two enzyme preparations showed physical and enzymic properties different from a kynurenine aminotransferase previously described. the two enzymes had nearly identical molecular weights (approximate 80 000), isoelectric points (ph 8.0) and ph optima (ph 8.0 - 8.5). however, a difference in substrate specificity was observed between the two enzym ... | 1978 | 25837 |
| cv-1 monkey kidney cell line -- a highly susceptible substrate for diagnosis and study of arboviruses. | the cv-1 cell line, derived from cercopithecus aethiops monkey kidneys, acquired in the course of serial passaging an epitheloid morphology and heteroploid karyotype. as compared with vero and gmk cell lines, the cv-1 line proved to be more susceptible to a broad spectrum of arboviruses belonging to the families togaviridae and bunyaviridae. most of them reached high titres and were markedly cytopathic in cv-1 cells so that all tests based on the cytopathic effect could be carried out. the cv-1 ... | 1978 | 26197 |
| biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man. | 3,4,4'-trichlorocarbanilide (tcc), uniformly labeled with 14c in the monochloro ring, was administered to rats, rhesus monkeys, and humans. radioactive materials in the plasma and urine of all three species and in the bile of rats and monkeys were separated by high performance liquid chromatography. the chromatography showed great similarity between the monkey and the human. principal metabolites common to all species were the sulfate and glucuronide conjugates of 2'-, 3'-, and 6-hydroxy-tcc. th ... | 1978 | 26533 |
| the physiological disposition of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in the rat, dog, rhesus monkey, and baboon. | | 1978 | 26553 |
| androgen concentration and partial characterization of 5alpha reductase in the epididymis of the rhesus monkey. | the 5alpha reductase activity ofthe monkey epididymis was studied. the enzyme was found in particulate subcellular fractions, its distribution closely resembling that of the microsomal marker enzyme nadph: cytochrome c reductase, suggesting an association of 5alpha reductase with membranes of the endoplasmic reticulum. maximal enzyme activity was found at ph 5.4 and at 32--37 c. the crude nuclear preparation had a km: 0.315 x 10(-6)m and vmax: 168 pmoles/mg protein/h. the microsomal enzyme had a ... | 1978 | 26992 |
| the influence of maternal psychological stress on the fetus. | the effects of maternal agitation, induced by exposure to bright light, upon fetal well-being were studied in pregnant rhesus monkeys at 139 to 148 days of gestation. fetuses were classified as "healthy" or "asphyxiated" according to their initial acid-base state. following variable periods of maternal excitement, a decrease in heart rate and arterial oxygenation was seen in all fetuses. recovery occurred more rapidly in the healthy group, after maternal sedation was achieved, either by removing ... | 1978 | 27097 |
| gamma-glutamyltransferase in human diploid fibroblasts and other mammalian cells. | gamma-glutamyltransferase was determined in wi-38 human diploid fibroblasts and compared to enzyme levels determined in several other mammalian cell lines including: fibroblast-like cells from human skin, tibia and foreskin; epithelial-like cells from human, bovine and monkey kidney; and transformed cells (chinese hamster ovary, hela s3 and sv-40 transformed wi-38). transformed cells had the lowest activity found followed in increasing order by fibroblasts, human and bovine epithelial cells and ... | 1978 | 27446 |
| effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. | the effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the gastrocnemius muscle (guinea-pigs and rats). pyridostigmine pretreatment produced a complete recovery of neuromuscular function following blockade by soman; the rate of recovery was similar in all the species, suggesting a common mechanism of action. in the absence o ... | 1978 | 27607 |
| volatile fatty acids and ph in the gastrointestinal contents of normal and shigella-infected monkeys. | | 1978 | 27663 |
| cell- and antibody-mediated responses to measles and mumps viruses in experimental animals. | monkeys and guinea pigs were immunized with various doses of measles and mumps viruses. a cell-mediated response measured by leukocyte migration inhibition occured during the first two weeks after immunization. in case of measles virus, marked migration inhibition occurred already on the 7th day in monkeys and guinea pigs immunized with high virus doses. the response declined as early as 14 days after immunization in contrast to the group of guinea pigs inoculated with a lower virus dose. in the ... | 1978 | 27968 |
| morphological characteristics of the infection of animals with tick-borne encephalitis virus persisting for a long time in cell cultures. | the pathogenicity of the soph-k strain of tick-borne encephalitis (tbe) virus produced by the persistently infected hep-2-soph cell culture was investigated in monkeys, white mice and hamsters. the persistent infection of this culture with tbe virus has been maintained for 17 years. the soph-k strain was shown to retain its pathogenic properties for mice of different ages and hamsters. morphological examinations of the brains and spinal cords of these animals infected with the soph-k strain reve ... | 1978 | 27969 |
| khasan virus, a new ungrouped bunyavirus isolated from haemaphysalis longicornis ticks in the primorie region. | strain leiv-776p, possessing no haemagglutinating activity was isolated in 1971 in the primorie region (u.s.s.r.) from haemaphysalis longicornis neumann 1091 tick. complement fixation (cf) tests revealed no antigenic relationship with 24 antigenic groups of arboviruses or 21 ungrouped viruses isolated from ticks. the virus isolate contains rna and is relatively sensitive to ether and sodium deoxycholate; it is pathogenic for suckling mice and two-week-old white mice by the intracerebral route, a ... | 1978 | 27977 |
| glutathione depletion following inhalation anesthesia. | glutathione depletion following inhalation of halogenated anesthetics was investigated as a possible mechanism of toxic reactions associated with anesthesia. concentrations of reduced glutathione were measured in the blood, liver, lung and kidney of the mouse after anesthesia with enflurane, fluroxene, halothane, isoflurane, methoxyflurane, or trichloroethylene. the anesthetic had no effect on glutathione concentrations in tissues except when fluroxene was used. after two hours of fluroxene anes ... | 1978 | 28682 |
| the neuropharmacological actions of amoxapine. | amoxapine possesses a broad spectrum of psychotropic actions, including antidepressant and neuroleptic effects in animals. antidepressant activity is characterized by its ability to inhibit tetrabenazine-induced depression, antagonize reserpine-induced hypothermia and enhance yohimbine lethality. neuroleptic activity is demonstrated by the ability of amoxapine to decrease locomotor activity, induce ptosis and catalepsy, inhibit apomorphine gnawing and amphetamine stereotyped behavior and by char ... | 1978 | 28699 |
| platelet monoamine oxidase activity in 116 normal rhesus monkeys: relations between enzyme activity and age, sex and genetic factors. | | 1978 | 28881 |
| disposition of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin) in beagle dogs and rhesus monkeys. | following intragastric doses of 14c-oxaprozin to beagle dogs and rhesus monkeys, oxaprozin was rapidly absorbed and was essentially the only drug-related substance in the plasma for at least 24 hr. recovery of radioactivity in the excreta was 87% in both species, with the fecal route accounting for almost all of the excretion by the dog, and the urinary route predominating in the monkey. the drug was slowly eliminated by both species. the concentrations in tissues of monkeys were generally less ... | 1978 | 28928 |
| serotonin sensitive adenylate cyclase activity in monkey anterior limbic cortex: antagonism by molindone and other antipsychotic drugs. | | 1978 | 29191 |
| absorption of the beta-adrenergic-blocking agent, nadolol, by mice, rats, hamsters, rabbits, dogs, monkeys, and man: an unusual species difference. | 1. dogs absorbed 14cnadolol almost completely (88--104%) after oral administration of 10--75 mg/kg. in contrast, mice, rats, hamsters, and rabbits, given oral doses of 20 mg/kg, absorbed, at most, 25%. after administration of oral doses of 2--75 mg/kg, monkeys absorbed no more than an average of 30%. six monkeys given oral doses of 10 mg/kg absorbed 12--44%. 2. in rats, 14cnadolol was orally absorbed to an average of 13.7--17.5%, whether given in suspension or in solution, indicating that absorp ... | 1978 | 29379 |
| the effects of isoproterenol on fetal oxygenation. | infusion of isoproterenol (1 microgram/kg/min, i.v.) into the anesthetized pregnant rhesus monkey near term consistently reduced fetal oxygenation, despite diminishing myometrial activity. the decline in po2 of fetal arterial blood (mean = 4.3 +/- 2.3 mmhg s.d.) was accompanied by an increase in pco2 tension (mean = 4.6 +/- 2.7 mmhg) and a decline in ph (mean = 0.04 +/- 0.02 s.d.). there was an increase in heart rate and a widening of pulse pressure in the mother and also in the adequately oxyge ... | 1978 | 29437 |
| cardiac systolic time intervals in fetal monkeys: pre-ejection period. | the systolic time intervals of the fetal cardiac cycle were studied by means of simultaneous recordings of electrocardiogram (ecg) and ultrasound doppler cardiogram (dcg) in chronic preparations of fetal rhesus monkeys. recordings were made under physiologic conditions as well as during various experimental stresses. the pre-ejection period (pep) showed no significant relationship with heart rate in the unstressed fetuses, but the acceleration of heart rate induced by epinephrine was accompanied ... | 1978 | 30282 |
| species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. | the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac), a new nonsteroidal anti-inflammatory agent, has been studied in rat, rabbit, dog, rhesus monkey, and man. animals were given single oral or parenteral doses of 5 or 50 mg/kg; man received approximately 3 mg/kg orally. fecal excretion of radioactivity occurred in the rat (26--37%) and dog (33--49%), whereas in the other species elimination was mainly urinary (less than 83%). biliary excretion accounted ... | 1978 | 30600 |
| comparative physiological disposition of ellipticine in several animal species after intravenous administration. | the physiological dispositon of ellipticine (nsc 71795) has been studied in the mouse, rat, dog and monkey after administration of [1-14c]ellipticine at 6 mg/kg iv (3 mg/kg to monkey). ellipticine was very rapidly distributed from the blood of all species and was deposited in tissues. the rate of elimination of ellipticine from blood was species-dependent, half-times ranging from 22 min in mouse to 210 min in rat, and probably reflected the rate of metabolism of the drug. the rate of elimination ... | 1978 | 30602 |
| pharmacology of lorazepam. | lorazepam reduced conflict behavior in rats and monkeys, inhibited pentylenetetrazol- and electroshock-induced convulsions, suppressed footshock-induced fighting behavior, and prevented morphine-induced stimulation in mice at lower doses than other benzodiazepines tested. this behavioral profile suggests that lorazepam will be an active anti-anxiety agent in man at low doses. | 1978 | 30764 |
| [role of volatile fatty acids and ph of the gastrointestinal contents in shigella infection in starved monkeys (author's transl)]. | | 1978 | 30852 |
| improved ventilation of prematurely delivered primates following tracheal deposition of surfactant. | twelve rhesus monkeys were delivered prematurely at 129, 130, or 131 days. the first breath was inhibited while tracheotomy was performed and a catheter introduced into the umbilical artery. into the tracheal tubes of six of the newborn monkeys was instilled 0.20 to 0.27 ml. of a natural surfactant (sa) suspension, obtained from lung wash of adult rabbits. nothing was given to six control monkeys. breathing was then supported with a ventilator. although its settings were adjusted in attempts to ... | 1978 | 31091 |
| [pharmacokinetic studies in monkeys after oral and intravenous administration of bromides and bromine-containing metabolites]. | | 1978 | 31158 |
| comparative studies on the steroid metabolism in mammals. i. characterization of 17 beta-hydroxysteroid dehydrogenase from monkey liver. | | 1978 | 31315 |
| synthesis of spiro[isobenzofuran-1(3h),4'-piperidines] as potential central nervous system agents. 4. central nervous system depressants. | the synthesis of 1'-[3-(4-fluorobenzyoyl)propyl]-3-phenylspiro[isobenzofuran-1(3h),4'-piperidine] (2a) and eight halo and methoxy analogues is described. the compounds were generally more potent per os than chlorpromazine in the sidman avoidance paradigm in rats and less potent than haloperido. 1'-[3-(4-fluorobenzoyl)propyl]-3-(4-fluorophenyl)spiro[isobenzofuran-1(3h),4'-piperidine] (2e) approached the per os potency of haloperidol in this test and was shown to be active in inhibiting monkey avo ... | 1978 | 31478 |
| bile duct cysts secondary to liver infarcts: report of a case and experimental production by small vessel hepatic artery occlusion. | hepatic bile duct cysts were demonstrated on an abdominal ct scan and confirmed at autopsy in a patient with polyarteritis nodosa. the cysts developed in close proximity to hepatic artery aneurysms and occlusions visualized at hepatic arteriography and confirmed postmortem. the development of similar bile duct cysts following hepatic artery occlusion was demonstrated in 13 rhesus monkeys. | 1979 | 31659 |
| regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide. | the positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with nadh and nadph. nad+ was a negative heterotropic effector, whereas nadp+ was without effect. the allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes. | 1978 | 31864 |
| transplantation of allogeneic bone marrow from thymus-deprived monkeys and certain characteristics of "graft-versus-host" cells. | transplantation of allogeneic bone marrow both from normal and thymus-deprived donors (thymectomized lethally irradiated and restored with autologous bone marrow) was followed 6--7 days later by the appearance of large numbers of gvh cells in bone marrow and peripheral blood which were one of the characteristic features of acute gvhr. gvh cells isolated from peripheral blood 7 days after transplantation showed a high labelling index (about 30%) after 40 min incubation with 3h-thymidine. the prol ... | 1978 | 32079 |
| etonitazene as a reinforcer: oral intake of etonitazene by rhesus monkeys. | drinking of etonitazene hci was studied in three rhesus monkeys during daily 3-h sessions. as the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (microgram/kg body weight) increased. as fixed-ratio (fr) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. when water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates ... | 1978 | 32572 |
| alpha-methyldopamine, a key intermediate in the metabolic disposition of 3,4-methylenedioxyamphetamine in vivo in dog and monkey. | metabolites of 3,4-methylenedioxyamphetamine in the urine of dogs and monkeys were separated by gas-liquid chromatography as their trifluoroacetyl and/or n-butyl ether derivatives and identified by comparison of the chromatographic and mass spectrometric behavior of these derivatives with those of synthetic compounds. the metabolites identified in dog and monkey urine were alpha-methyldopamine, 3-o-methyl-alpha-methyldopamine, and 3,4-dihydroxybenzyl methyl ketone. the monkey urine also containe ... | 1978 | 33023 |
| evaluation of succinimidoethyl and pivaloyloxyethyl esters as progenitors of methyldopa in man, rhesus monkey, dog, and rat. | the succinimidoethyl (sm) and pivaloyloxyethyl (p) esters of methyldopa were evaluated as progenitors of the latter. experiments in spontaneously hypertensive (sh) rats and humans demonstrated that a radioactive dose of progenitor was well absorbed. the metabolism of these progenitors appeared to be comparable in the sh rat; the urinary excretion of [3h]methyldopa was similar after oral administration of [3h]sm or [3h]p. in humans the levels of [3h]methyldopa were higher in the urine following a ... | 1978 | 33026 |
| physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man. | the absorption, distribution, excretion, and metabolism of 3-(5 h-dibenzo[a,d]cyclohepten-5-ylidene)-n,n-dimethyl-1-propanamine (cyclobenzaprine) were investigated in the rat, dog, rhesus monkey, and man. the drug was well absorbed in all species after oral administration. the rat eliminated the drug primarily in the feces, but urinary excretion was predominant in the dog, monkey, and man. the drug was rapidly and widely distributed into rat tissues, highest concentrations being found in the sma ... | 1978 | 33029 |
| cerebrovascular effects of yc-93, a new vasodilator, in dogs, monkeys and human patients. | cerebrovascular effects of yc-93, a new 1,4-dihydropyridine derivative, was examined in experimental animals and in human patients using a variety of methods. yc-93 in doses ranging from 0.001 to 0.03 mg/kg i.v. increased regional cerebral cortical blood flow and cerebral venous outflow in anesthetized dogs, and internal carotid blood flow in anesthetized monkeys. the increase in cerebral blood flow was accompanied by an increase in oxygen delivery to the brain and an elevation of cerebrospinal ... | 1979 | 33121 |
| affinity chromatography and separation of the molecular forms of monkey brain alpha-l-fucosidase on fucose-linked sepharose. | a simple affinity system which required coupling of alpha-l-fucose to sepharose 4b by epichlorohydrin treatment of sepharose 4b in the presence of alpha-l-fucose under alkaline conditions has been described. a partially purified preparation of monkey brain alpha-l-fucosidase (alpha-l-fucoside fucohydrolase, ec 3.2.1.51) was resolved at ph 5.0 into two major fractions: one bound and one retarded. the enzyme bound to the affinity column and specifically eluted by 2 mm alpha-l-fucose at ph 5.0 appe ... | 1979 | 33716 |
| longitudinal study of experimentally induced periodontal disease in macaca arctoides: relationship between microflora and alveolar bone loss. | macaca arctoides monkeys develop periodontal disease, and they harbor a periodontopathic indigenous flora largely similar to that of humans. this study showed that various haemophilus isolates and h2o2-splitting asaccharolytic bacteroides melaninogenicus strains constituted major segments of the monkey periodontal microflora. these organisms have not been previously identified among human isolates. furthermore, the present data revealed that asaccharolytic b. melaninogenicus strains increased in ... | 1979 | 33902 |
| alphaviruses in peninusular malaysia: i. virus isolations and animal serology. | a survey of the activity of three alphaviruses (sindbis, getah and chikungunya) in peninsular malaysia was conducted between 1962 and 1970. serum samples were examined from 3,917 vertebrates representing a wide variety of wild and domestic animals throughout the peninsula for hemagglutination-inhibiting and neutralizing antibodies. a total of 548,939 mosquitoes were collected from different habitats, including jungle, rural, suburban and urban areas, and the majority of the females taken were ex ... | 1978 | 34888 |
| [experimental study of barbiturate application following anoxic encephalopathy]. | the protective effect of thiopental on neurological lesions provoked by cerebral anoxie was studied in the monkey. cerebral ischemia was induced by a cervical tourniquet applied for a period of 16 minutes. a control series of 10 animals received only the normal resuscitation. a series of 27 monkeys received either 90 mg/kg of thiopental at 5, 10, 15, 30 or 60 minutes following ischemia, or 120 mg/kg at the 30th or 60th minute. one third of the dose was administered within 5 minutes and the rest ... | 1978 | 35054 |
| pharmacological studies on cs-430, a new psychotropic agent. | 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5h)-one (cs-430) is a new psychotropic drug and has the following properties. the compound showed sleep-inducing effect at both 0.2 and 5 mg/kg (p.o.) in cynomolgus monkeys or at 3 mg/kg (p.o.) in rats. cs-430 showed selective conflict attenuating in rats or anticonvulsant effects in mice. furthermore, cs-430 blocked non-discriminated (sidman) avoidance response without severe impairment of the motor function bu ... | 1978 | 35173 |
| toxicology of clobazam. | 1 extensive toxicological investigations of clobazam are summarized. 2 ld50 values after oral administration ranged from 100 mg/kg in the dog to 6000 mg/kg in the rat. 3 long-term repeated dose studies have shown withdrawal effects in the dog and monkey (notably convulsions leading to death), similar to those known to occur with other benzodiazepines. 4 it is concluded that the overall safety and tolerability of clobazam have been demonstrated in the preclinical animal studies. | 1979 | 35202 |
| the metabolic disposition of norgestrel in female rhesus monkeys. | following single intragastric doses of d- and dl-[24c]norgestrel (ng), rhesus monkeys excreted 29.5 +/- 2.0 (se) and 52.6 +/- 5.4% of the administered radioactivity in urine. fecal excretion accounted for 57.1 +/- 4.0 and 37.2 +/- 4.4%, respectively. urinary radioactivity was separated into neutral, acidic, and conjugated fractions. the neutral and conjugated fractions contained ng; 2 alpha, 16 alpha- and 16 beta-hydroxy-ng; 3 alpha,5 beta-tetrahydro-ng and 16 beta-hydroxy-3 alpha,5 beta-tetrahy ... | 1979 | 35318 |
| neurologic and cardiovascular effects of hypotension in the monkey. | thirty monkeys were exposed to controlled systemic hypotension of different magnitudes and duration to determine factors leading to brain injury or cardiovascular failure. fourteen monkeys developed brain injury. of these, 6 survived indifinitely and 8 were sacrificed or died within 12-62 hours due to neurologic deterioration accompanied by respiratory failure. sixteen animals did not develop brain injury, but 9 of these died within 24 hours from documented cardiovascular failure with the remain ... | 1979 | 35862 |
| airway sensitivity to slow-reacting substance of anaphylaxis, histamine, and antigen in ascaris sensitive monkeys. | the effects of ascaris suum antigen, histamine, and slow-reacting substance of anaphylaxis (srs-a) on the respiratory system were compared in 3 anesthetized rhesus monkeys. the agents were administered by instillation into the trachea, and the animals were studied in a volume displacement body plethysmograph. two of the animals showed skin and bronchial sensitivity to ascaris suum antigen and responded to it with increased pulmonary resistance and decreased dynamic compliance. a similar response ... | 1979 | 36017 |
| the effects of h1 and h2 receptor antagonism on the response of monkey skin to intradermal histamine, reverse-type anaphylaxis, and passive cutaneous anaphylaxis. | the effects of h1 and h2 receptor anatagonists on models of allergic reactions in monkey skin have been studied. intradermal histamine is markedly inhibited by h1 receptor antagonists but not by h2 receptor antagonists in the doses used. however, the combination of both receptor antagonists gives greater inhibition than that seen with h1 receptor blockade alone. reverse-type anaphylaxis is also markedly inhibited by h1 but not h2 receptor antagonists. passive cutaneous anaphylaxis (pca) is likew ... | 1979 | 36420 |
| four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys. | aged rhesus monkeys and young control monkeys were tested in a delayed-response procedure to assess the effects of central-nervous-system (cns) stimulants on short-term memory (stm). previous research had established that the aged monkeys showed specific impairments of stm in this procedure. four different cns stimulants (methylphenidate, magnesium pemoline, a pentylenetetrazole/niacin mixture, and caffeine) were chosen for evaluation on the basis of their relevancy to current geriatric-psychoph ... | 1979 | 36423 |