| [potential filaricides. suramin analogs]. | a series of suramin analogues has been synthesized in which the methyl groups of suramin have been replaced by hydrogen, alkyl, phenyl, and fluoro substituents, or which contain more than two methyl groups. the substances have been screened against dipetalonema viteae in meriones unguiculatus, litomosoides carinii in sigmodon hispidus and l. carinii in mastomys natalensis, respectively. small structural modifications have a marked influence on the antifilarial activity. there are marked differen ... | 1986 | 3778551 |
| the effect of diethylcarbamazine on microfilariae of litomosoides carinii in vitro and in vivo. | culture-derived litomosoides carinii microfilariae (mff) were used in in vitro and in vivo systems to investigate the effect of diethylcarbamazine (dec) on these mff. in vivo: male rats, mastomys natalensis, all of the same age, were injected intrathoracically (12) or intraperitoneally (36) with 10(3) or 10(4) mff. after 30 min one half of each group of rats was given dec per os. at 30, 60, and 120 min after dec administration, two rats from the treated and two from the untreated group were bled ... | 1986 | 3799010 |
| effects of the juvenile hormone antagonist precocene ii and the moulting hormone 20-oh-ecdysone on litomosoides carinii and dipetalonema viteae in vitro. | | 1986 | 3799015 |
| the effect of precocene ii and 20-oh-ecdysone on litomosoides carinii and dipetalonema viteae in vivo. | | 1986 | 3799016 |
| macrophage migration inhibition test of peritoneal exudate cells of litomosoides carinii-infected cotton rats by direct method in agar plate. | the macrophage migration inhibition test (mit) was successfully made in agar plates using peritoneal exudate cells (pec) of cotton rats, sigmodon hispidus, during infection with litomosoides carinii. it was found that 1% bacto agar plate containing heat-inactivated serum was most suitable for the migration of pec of the cotton rat induced by liquid paraffin injection. ten percent normal cotton rat serum mixed in agar plate was best for pec migration as compared with the various concentrations of ... | 1985 | 3904853 |
| synthesis and anthelmintic activity of 5(6)-(benzimidazol-2-ylcarbamoyl) and (4-substituted piperazin-1-yl)benzimidazoles. | the synthesis of alkyl 5(6)-(benzimidazol-2-ylcarbamoyl)benzimidazole-2-carbamates (6, 7), and alkyl 5(6)-(4-substituted piperazin-1-yl)benzimidazole-2-carbamates (31-40) has been carried out. when the compounds were tested for their anthelmintic activity against ancylostoma ceylanicum in hamsters, hymenolepis nana in rats, litomosoides carinii in cotton rats, and dipetalonema viteae in mastomys natalensis, methyl 5(6)-(4-benzoylpiperazin-1-yl)benzimidazole-2-carbamate (31), methyl 5(6)-[4-(2-fu ... | 1985 | 3906129 |
| [suppression of the parasitemia in rodent filariasis (litomosoides carinii) by immunization with bcg and microfilaria. ii. intravenous bcg application]. | by intravenous (i.v.) inoculation of living tuberculosis bacteria (bcg) non-specific resistance to microfilariae of litomosoides carinii (filarioidea) is induced in cotton rats. this is only possible using the preparation "immune-bcg pasteur f" (suspended germs), but not with "vaccin-bcg pour scarifications" (lyophilized tuberculosis bacteria). after inoculation of immune-bcg, followed by a challenge infection by 60 infective larvae 6 weeks later, a patent infection develops. however, the level ... | 1985 | 3909680 |
| respiration and energy conservation in the filarial worm litomosoides carinii. | the average rate of endogenous respiration of intact litomosoides carinii was 2.24 muatom o min-1 g-1 worm wet wt. no significant difference was observed in respiration capacities between male and female worms. rates of oxygen uptake decreased progressively during disruption and fractionation of the parasite tissue and very few respiration capabilities remained in the mitochondrial fraction. added substrates increased the respiratory rates of the intact filariid and cell-free extracts by a facto ... | 1985 | 3990708 |
| immune reactions to exsheathed microfilariae of litomosoides carinii. | | 1985 | 4018857 |
| immunity to litomosoides carinii in mastomys natalensis. i. effect of immunization with microfilariae and existing primary infections on the parasitaemia after microfilariae injection and challenge infection. | subcutaneous injections of intrauterine stages of litomosoides carinii into mastomys natalensis induced strong immunity to i.v. injected blood microfilariae. immunity, developed after boostering with an i.p. and an i.v. injection of microfilariae, did not totally suppress the parasitaemia of a challenge infection but reduced significantly the microfilaraemia level. no effect was found on number and size of the worms of the challenge infection, the number of microfilariae or the number of leucocy ... | 1985 | 4050030 |
| cellular immune status in rodents infected with litomosoides carinii. | | 1985 | 4054974 |
| helminths of sympatric populations of kangaroo rats (dipodomys ordii) and grasshopper mice (onychomys leucogaster) from the high plains of eastern new mexico. | during a 1-yr period 124 dipodomys ordii and 92 onychomys leucogaster were trapped from the same locality and were examined for helminths. only 1 cestode species (catenotaenia linsdalei) was recovered from d. ordii, whereas o. leucogaster was infected with 2 nematoda (litomosoides carinii, mastophorus muris), 2 cestoda (hymenolepis citelli, and 1 unknown), and 1 acanthocephalan (moniliformis clarki) species. all represent new host and distribution records. | 1985 | 4057002 |
| litomosoides carinii: retardation of worm growth and of migration of challenge infections in jirds (meriones unguiculatus). | inbred jirds (meriones unguiculatus) were divided into three groups; each animal in two of the groups was infected with 30 infective larvae (l3) of litomosoides carinii. when these infections were patent, the jirds of one of the two infected groups plus those of the third group were injected with 30 l3 l. carinii each. all animals were killed either on day 14 or 24 after the second infection for the recovery, enumeration and measurement of all worms and developing larvae. challenge larvae were s ... | 1985 | 4067241 |
| [natural infection of holochilus brasiliensis nanus thomas, 1897 (rodentia, cricetidae) by litomosoides carinii]. | it is recorded the natural infection of holochilus brasiliensis nanus, a small semi-aquatic rodent of the occidental lowland of maranhão state, brazil, by litomosoides carinii. | 1985 | 4088043 |
| glycolysis in litomosoides carinii, the filarial parasite of the cotton rat. | | 1970 | 4323388 |
| implant chemotherapy of experimental filariasis. | the in vitro diffusion of the organophosphate famphur from polydimethylsiloxane (pds) capsules into plasma and their effects on litomosoides carinii and dipetalonema witei in jirds was studied. the in vitro rate of diffusion per 24 hours was constant and was directly proportional to the capsule lumen surface area and inversely proportional to the capsule wall thickness. one capsule implanted subcutaneously into each jird almost completely eliminated the microfilaremia of l. carinii while in situ ... | 1974 | 4476193 |
| urinary non-protein nitrogen fractions in litomosoides carinii infected albino rats. | | 1972 | 4663242 |
| amyloidosis in mongolian gerbils infected with litomosoides carinii. | | 1973 | 4742086 |
| [litomosoides carinii infection of mastomys natalensis: alterations of haematological parameters (author's transl)]. | | 1973 | 4770091 |
| letter: pathological changes in white rats infected with litomosoides carinii. | | 1973 | 4788769 |
| comparative effects of 3-ethyl-8-methyl-1,3,8-triazabicyclo(4,4,0)decan-2-one and diethylcarbamazine against litomosoides carinii in rodents. | 3-ethyl-8-methyl-1,3,8-triazabicyclo[4,4,0]decan-2-one and diethylcarbamazine were tested comparatively against litomosoides carinii in mongolian jirds and cotton rats. the drugs were compared in jirds by oral and by intraperitoneal administration. comparisons in cotton rats were done by intraperitoneal administration. the drugs were given in a wide range of doses twice daily for 4 consecutive days. parameters used for judging efficacy included the rate, degree, and duration of microfilaremia su ... | 1973 | 4790619 |
| [litomosoides carinii infection of mastomys natalensis: serological studies with the complement fixation and the indirect haemagglutination test in the course of infection (author's transl)]. | | 1974 | 4833626 |
| [litomosoides carinii infection of mastomys natalensis: relationship between microfilaraemia and adult worm population (author's transl)]. | | 1974 | 4836671 |
| notes on the host-parasite relationship during infection of praomys (mastomys) natalensis with the filarial parasite litomosoides carinii. | | 1974 | 4853378 |
| comparative biochemical studies of litomosoides carinii, dipetalonema viteae, and brugia pahangi adults. | | 1974 | 4856594 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 4. the prophylactic and suppressive activity of suramin. | | 1974 | 4857965 |
| [precipitating antibodies in the serum of mastomys natalensis in the course of litomosoides carinii infection]. | | 1970 | 4993040 |
| [a rational method for the quantitative infection of susceptible hosts with the filarial nematode litomosoides carinii]. | | 1972 | 5050529 |
| studies on quantitative infections of litomosoides carinii (travassos, 1919) in white rats. | | 1971 | 5134871 |
| hemagglutination test with litomosoides carinii antigen in the diagnosis of cotton rat filariasis. | | 1968 | 5303609 |
| purification and recovery of the antigen derived from adult litomosoides carinii for hemagglutination test. | | 1968 | 5307364 |
| the sequential appearance of 19s and 7s antibody in cotton rats infected with the cotton rat firalia, litomosoides carinii. | | 1969 | 5309562 |
| the development of antibodies in the cotton rats transplanted with the adult cotton rat filaria, litomosoides carinii. | | 1969 | 5310936 |
| antigenicity of excretory and secretory products of the cotton rat filaria, litomosoides carinii. | | 1970 | 5310939 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 1. the filaricidal action of 2,6-bis-benzimidazoles. | the antifilarial action of 2-[2-(4-hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl) benzimidazole (hoe 33258) was investigated in mastomys natalensis infected with litomosoides carinii. the subcutaneous administration of hoe 33258 in a single daily dose for 5 consecutive days, or at other intervals, produced, depending on the dosage, a rapid reduction in the number of microfilariae in the circulating blood. the reduction amounted to more than 90% within 7-14 days after the treatment was ... | 1971 | 5317445 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 2. the activity of drugs against microfilariae. | comparative investigations of the chemotherapeutic activity of various filaricidal compounds and other anthelmintics were made with litomosoides carinii infections in mastomys natalensis, special consideration being given to the microfilaricidal activity of the compounds. diethylcarbamazine, cyclohexanecarboxylic acid-n-methylpiperazide citrate (hoe 28637a), tetrahydropyranecarboxylic acid-n-methylpiperazide citrate (hoe 29691a), (+/-)-tetramisole, (-)-tetramisole (levamisole), and metrifonate p ... | 1971 | 5317446 |
| chemotherapeutic studies on litomosoides carinii infection of mastomys natalensis. 3. the activity of drugs against adult parasites. | comparative studies of the chemotherapeutic activity of various filaricides were carried out and the results in litomosoides carinii infections of mastomys natalensis were analysed with special reference to macrofilaricidal activity. the administration of suramin in daily subcutaneous doses of 40 mg per kg of body weight for 5 consecutive days showed marked activity against macrofilariae and killed the adult worms within 6 weeks after the beginning of treatment. the microfilarial count of the ci ... | 1971 | 5317447 |
| antifilarial agents. i. effects of 4-[(7-chloro-4-quinolyl)amino]-alpha-(mono- and dialkylamino)-o-cresos and related compounds against litomosoides carinii in gerbils. | | 1969 | 5351475 |
| [analytical studies on extracts of litomosoides carinii]. | | 1969 | 5385165 |
| [the albumin-globulin ratio in the serum of mastomys natalensis (smith, 1834) in the coruse of infection with litomosoides carinii]. | | 1970 | 5436819 |
| the filaricidal effect of basically substituted 2,6-bis-benzimidazoles in litomosoides carinii infection of the cotton rat (sigmodon hispidus). | | 1971 | 5575895 |
| [quantitative study methods for the demonstration of microfilaria (litomosoides carinii) with the help of the fuchs-rosenthal and jessen counting chamber as well as concentration tests]. | | 1967 | 5589391 |
| [the invasion route of the metacyclical larvae of litomosoides carinii chandler 1931 (filariidae)]. | | 1967 | 5597703 |
| [infection experiments with the cotton rat filaria litomosoides carinii chandler 1931 (filariidae) in inadequate hosts]. | | 1967 | 5603181 |
| [effects of oxygen deficiency in the respiratory air on microfilaremia (litomosoides carinii) (filariidae) in the cotton rat]. | | 1967 | 5613457 |
| ultrastructural changes in litomosoides carinii microfilariae in gerbils treated with diethylcarbamazine. | | 1968 | 5647120 |
| studies on the host-parasite relation in albino rats infected with litomosoides carinii. | | 1968 | 5726133 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. i. a preliminary comparison of the host effciency of the multimammate rat, praomys (mastomys) natalensis, with that of the cotton rat, sigmodon hispidus. | | 1968 | 5729256 |
| some developments in techniques for the study of the rodent filarial parasite litomosoides carinii. ii. a quantitative method for the culture of the mite ornithonyssus bacoti and for the routine transmission of litomosoides carinii to praomys (mastomys) natalensis. | | 1968 | 5729257 |
| [infection experiments with the cotton rat filaria litomosoides carinii in mastomys natalensis (smith, 1834)]. | | 1968 | 5746888 |
| chemotherapeutic reactions of chandlerella hawkingi, the filarial parasite of the indian jungle crow, corvus macrorhynchos (agler). | 1. a high percentage of indian jungle crows (corvus macrorhynchos wagler), found in and around lucknow, harbour a natural filarial infection chandlerella hawkingi. the microfilariae of this species are sheathed and show nocturnal periodicity.2. fourteen compounds active against other kinds of filariae, especially against litomosoides carinii, were tested against ch. hawkingi in jungle crows to find whether this infection would be suitable for routine filarial chemotherapy. this is apparently the ... | 1969 | 5774047 |
| effects of mel w against litomosoides carinii in mongolian gerbils. | | 1966 | 5951286 |
| the effect of x-irradiation on the survival of liponyssus bacoti and on its susceptibility to infection with litomosoides carinii. | | 1966 | 5960108 |
| effect of antimitotic agents on a filarial worm (litomosoides carinii) in vivo. | | 1967 | 6062073 |
| filarial infections of mastomys natalensis and their relevance for experimental chemotherapy. | experimental filarial infections of mastomys natalensis, strain gra giessen, with litomosoides carinii, dipetalonema viteae, brugia malayi (subperiodic), and brugia pahangi were compared. mean prepatent periods of 52, 57, 107, and 73 days p.i. were observed after subcutaneous inoculation of 40, 50, 85, and 70 infective larvae of l. carinii, d. viteae, b. malayi, and b. pahangi, respectively, in the neck region. all of the l. carinii, d. viteae, and b. pahangi infected mastomys showed a regularly ... | 1981 | 6118036 |
| immunogenicity of homogenates of the developmental stages of litomosoides carinii in albino rats. | homogenates of different developmental stages of the filarial parasites, l. carinii, emulsified in freund's complete adjuvant have been examined for their efficacy in conferring immunity to the infection in the albino rats. the results revealed that sonicated preparations of microfilariae and infective larvae induce high resistance to the infection in the animals. in contrast, soluble antigens of adults and sonicated homogenates of adult males were ineffective to induce such resistance. some res ... | 1981 | 6118040 |
| diethylcarbamazine dependent, complement mediated, adherence and cytotoxicity of cells on microfilariae of litomosoides carinii. | diethylcarbamazine (dec) induced dose dependent adherence of normal spleen cells from mastomys natalensis to microfilariae of l. carinii in the presence of serum from mastomys infected with l. carinii or normal serum. the effect could be also induced, using fresh, normal human serum and human blood leucocytes. the responsible serum factor was heat labile (56 degrees c, 30 min) and was eliminated from the sera by pretreatment with inulin. the activity could be reconstituted by normal serum. cell ... | 1983 | 6136173 |
| different suitability of 3 filarial antigens (litomosoides carinii, dipetalonema viteae, dirofilaria immitis) to act as allergens in the passive cutaneous anaphylaxis test and to serve as antigens in an elisa in the course of experimental filarial infections (l. carinii, d. viteae, brugia malayi, b. pahangi) of mastomys natalensis. | crude extracts of adult worms of 3 different filariae (litomosoides carinii, dipetalonema viteae, dirofilaria immitis) were evaluated for their suitability to serve as allergens in the passive cutaneous anaphylaxis test (pca) and as antigens in an elisa which detected mainly igg antibodies. studies were done in the course of 4 different filarial infections (l. carinii, d. viteae, brugia malayi, b. pahangi) of mastomys natalensis, using sera from different times after infection up to 350 days p.i ... | 1984 | 6143483 |
| shared antigens between litomosoides carinii and its hosts sigmodon hispidus and mastomys natalensis. | using a indirect immunofluorescent technique it has been shown that host or host-like antigens are present on adults and microfilariae of litomosoides carinii from cotton rats and multimammate rats. red blood cell components were seldom detected on any stage but serum antigens were found associated with the cuticle of adults worms. serum components were absent from in utero and in vitro microfilariae but were found on microfilariae from pleural exudate and host blood. these components were lost ... | 1981 | 6179274 |
| isolation of antigen from litomosoides carinii macrofilariae detecting serum antibodies due to onchocerca volvulus. | crude aqueous litomosoides carinii adult worm extract was used as antigen for the detection of antibodies in sera from african patients with proven onchocerciasis (n = 45) resident in rural endemic areas of togo and sierra leone. in 71% of cases this extract was found to produce 1 to 5 precipitation arcs in immunoelectrophoresis. using a crude aqueous extract from adult onchocerca volvulus, precipitation tests were positive in 75% of cases. the complexity of the l. carinii crude extract was show ... | 1983 | 6192603 |
| surface proteins of a filarial nematode: a major soluble antigen and a host component on the cuticle of litomosoides carinii. | the surface composition of three stages in the life cycle of litomosoides carinii, a filarial parasite of rodents, has been studied using radio-iodination techniques. confirmation that radiolabelled components were confined to the parasite surface was achieved using light and electron microscope autoradiography. biochemical analysis of extracts of radiolabelled parasites by sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) revealed that one major component (mol. wt. 55 000) c ... | 1984 | 6199718 |
| serodiagnosis of human onchocerciasis: evaluation of sensitivity and specificity of a purified litomosoides carinii adult worm antigen. | sensitivity and specificity of a litomosoides carinii macrofilariae aqueous crude extract and a purified antigen which was isolated by preparative flat bed electrofocusing, were evaluated for the immunodiagnosis of human onchocerciasis in 3 serological tests: double diffusion test (dt), latex agglutination test (lat) and elisa. testing sera from proven cases of onchocerciasis (n = 28), loiasis (n = 4) filariasis bancrofti (n = 4), and other non filarial helminth infections (n = 29) in all tests ... | 1984 | 6205486 |
| [histochemical studies on the effect of furapyrimidone on litomosoides carinii in cotton rats]. | | 1982 | 6219547 |
| uptake of adenosine 3',5'-cyclic monophosphate and isoproterenol by filarial parasites. | the filarial parasites litomosoides carinii and dipetalonema viteae both show transcuticular uptake of adenosine 3',5'-cyclic monophosphate but isoproterenol is taken up by d. viteae only. the importance of this difference is discussed from the point of view of metabolic regulation. inhibition of uptake by lectins indicates the involvement of surface sugar moieties in the transport processes. | 1983 | 6321589 |
| the survival of adult litomosoides carinii transplanted into cotton rats previously injected with irradiated stage 3 larvae. | adult litomosoides carinii were surgically removed from the pleural cavities of normal cotton rats which had been infected 35 days previously by the inoculation of normal stage 3 larvae. groups of 20 such worms were then transplanted into either the pleural cavities of other normal, uninfected cotton rats or into the pleural cavities of cotton rats which had previously received, by subcutaneous injection, either 3 x 50 l3 which had been exposed to 40 krads cobalt 60 irradiation or 1 x 50 l3 irra ... | 1983 | 6342238 |
| immunodiagnosis of bancroftian filariasis by enzyme linked immunosorbent assay using litomosoides carinii and setaria cervi antigens. | an elisa was developed using cross-reacting antigens of litomosoides carinii and setaria cervi to detect antibodies in filarial patients. the diagnostic potential of the test was investigated in 80 symptomatic cases of filariasis, 40 asymptomatic carriers and 50 normal subjects of an area around lucknow endemic for bancroftian filariasis. by the criteria laid down for elisa positivity for filariasis, 86.2% of the symptomatic cases could be detected by this test. only four of 40 asymptomatic carr ... | 1983 | 6356499 |
| action of three filaricides on adult litomosoides carinii. | | 1983 | 6358010 |
| alternative animal host for cotton rat filarial worm litomosoides carinii. | | 1983 | 6360861 |
| effect of stimulation and blockade of mononuclear phagocyte system on the treatment of microfilaremia of litomosoides carinii in the cotton rat and the jird. | the role of mononuclear phagocyte system (mps) in the effect of diethylcarbamazine (dec) for clearing microfilariae of litomosoides carinii from the blood stream was studied in the cotton rat and the jird, using diethylstilbestrol (des) for the stimulation of mps and carrageenan (cgn) for the blockade of mps. the level of microfilaremia was not influenced by administration of des subcutaneously or cgn intraperitoneally, indicating that the circulating microfilariae in naturally infected animals ... | 1984 | 6381821 |
| the response to litomosoides carinii to antifilarial agents in cotton rat (sigmodon hispidus) & multimammate rat (mastomys natalensis). | | 1984 | 6394476 |
| comparison of activities of mononuclear phagocyte system between the cotton rat, sigmodon hispidus, and the jird, meriones unguiculatus, in relation to the treatment of filariasis. | the cotton rat and jird, matched according to age and the period after infection with litomosoides carinii, were administered intraperitoneally with diethylcarbamazine (dec) at a single dose of 100 mg/kg. microfilaria counts were conducted 0.5, 1, and 6 hrs and 1, 4, and 7 days after treatment with dec. the average of percent microfilaria density was significantly higher in the jird than in the cotton rat at any given time except at 6 hrs, when a slight increase was observed in the cotton rat. t ... | 1983 | 6394848 |
| a mass dissection method for collecting infective larvae of litomosoides carinii from mites. | | 1984 | 6398836 |
| sequential changes in antibody response of mastomys natalensis during the course of litomosoides carinii infection. | | 1983 | 6429235 |
| lymphatic filariasis in man: demonstration of circulating antigens in wuchereria bancrofti infection. | five hundred and twenty-nine sera obtained from people dwelling in an area endemic for bancroftian filariasis were analysed for the presence of soluble circulating antigens (sca) of filarial origin by counter immunoelectrophoresis and 303 were found positive. it, therefore, appears that 57.3% subjects could be diagnosed by the detection of sca irrespective of their clinical status. of the three groups investigated, microfilaraemic, amicrofilaraemic and clinical, sca could be demonstrated in maxi ... | 1984 | 6433305 |
| immunodiagnosis of giardiasis by elisa and studies on cross-reactivity between the anti-giardia lamblia antibodies and some heterologous parasitic antigens and fractions. | specific antibodies against giardia lamblia in 92 sera from asymptomatic carriers were investigated by elisa. using cyst antigen, antibodies were detected in 91 of the sera, by means of alkaline phosphatase-labelled antispecies immunoglobulin. the e/405nm values of the positive sera ranged between 0.350 and 1.700, whereas in the 78 control sera they were 0.270 +/- 0.220. cross-reactivity between the anti-g. lamblia antibodies and 18 heterologous parasitic antigens and fractions was also studied. ... | 1984 | 6486935 |
| effect of diethylcarbamazine on serum-dependent cell-mediated immune reactions to microfilariae in vitro. | the effect of diethylcarbamazine citrate (dec) on serum-dependent cellular adherence and cytotoxicity to sheathed and exsheathed microfilariae of litomosoides carinii and brugia pahangi in vitro has been investigated. dec at 5 micrograms/ml promoted antibody-mediated neutrophil adherence and cytotoxicity with sheathed l. carinii microfilariae. with exsheathed parasites, the drug promoted significantly complement-and antibody-mediated cellular adherence and cytotoxicity. in the case of b. pahangi ... | 1984 | 6495386 |
| separation of viable microfilariae free of blood cells on percoll gradients. | a consistent and reproducible method is described for isolating pure populations of microfilariae of litomosoides carinii, brugia pahangi, b. malayi and dipetalonema viteae, free of cells, from blood, by density gradient centrifugation on percoll in 0.25 m sucrose. the recovery of the microfilariae was 85 to 97%. | 1984 | 6538892 |
| microfilarial periodicity in mastomys natalensis. | the microfilarial level in the peripheral blood of mastomys natalensis infected with the filarial parasites, litomosoides carinii, brugia pahangi, b. malayi and dipetalonema viteae was monitored at two-hour intervals for 24 hours. the microfilariae of b. pahangi and b. malayi exhibited nocturnal and diurnal subperiodicity, respectively; no such periodicity was seen in l. carinii and d. viteae infections. the level of b. pahangi and d. viteae microfilariae in peripheral blood was significantly in ... | 1984 | 6540281 |
| syntheses and anthelmintic activity of alkyl 5(6)-(substituted-carbamoyl)- and 5(6)-(disubstituted-carbamoyl)benzimidazole-2-carbamates and related compounds. | a number of alkyl 5(6)-(substituted-carbamoyl)- and 5(6)-(disubstituted-carbamoyl)benzimidazole-2-carbamates and related compounds have been synthesized, and their anthelmintic activity against various intestinal helminths of experimental animals have been evaluated. a large percentage of the compounds synthesized showed noteworthy activity against ancylostoma ceylanicum and at higher doses against hymenolepsis nana infections. compared to the alkyl 5(6)-(substituted-carbamoyl)benzimidazole-2-ca ... | 1984 | 6540312 |
| protein kinases in different life stages of brugia malayi and other filarial worms. | the investigation of protein kinase activity in different life stages of a few filarial worms indicates the presence of different protein kinases and of dissimilarities between the distribution pattern of these enzymes during the development. phosvitin turned out to be the preferred exogenous acceptor protein, when homogenates of adults of brugia malayi, dipetalonema viteae, setaria cervi and litomosoides carinii were used as source of enzyme. in contrast to adults the l3-larval and the microfil ... | 1984 | 6541823 |
| uptake of diethylcarbamazine by microfilariae and adults of litomosoides carinii and dipetalonema viteae. | microfilariae of litomosoides carinii and dipetalonema viteae absorbed about ten times as much diethylcarbamazine (dec) as did their adults, but bound much less. the higher uptake of dec by the microfilariae might be related to the fact that dec is microfilaricidal. binding of dec with the parasites supports the view that the microfilaricidal action begins with the fixation of the drug to the microfilariae. | 1984 | 6542115 |
| studies of potential filaricides: part 14--activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis. | the synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against litomosoides carinii in sigmodon hispidus and dipetalonema viteae in mastomys natalensis is reported. at an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult l. carinii. however, it killed all microfilariae and adults of d. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. the compound also possessed chemo ... | 1984 | 6542118 |
| [filariasis of the eye: problems with animal models]. | twelve rodents (mastomys natalensis and meriones persicus) were infected, with l3 larvae of litomosoides carinii and dipetalonema viteae. eighty days after infection the number of microfilariae (l1 larvae) was determined by smears from the peripheral venous blood. it was found that there were 48 and 69 x 10(3) microfilariae per ml blood. the hosts were killed and the eyes (conjunctiva, cornea, uvea, posterior part of the globe, optic nerve) as well as other organs (skin, brain, liver, heart and ... | 1983 | 6645261 |
| comparative efficacy of some benzimidazoles and amoscanate (go.9333) against experimental filarial infections. | the comparative efficacy of mebendazole, fenbendazole, oxibendazole, oxfendazole, albendazole, flubendazole and micronized amoscanate (particle size 5-8 micron) against litomosoides carinii and brugia pahangi infections in mastomys natalensis was studied on administration of the compounds per os (150 mg/kg/day for 5 days) and subcutaneous (100 mg/kg/day for 5 days) routes. it was found that benzimidazoles when given by the oral route had no effect on adults of l. carinii and b. pahangi. with mos ... | 1983 | 6665868 |
| effect of arsenical drugs on glutathione metabolism of litomosoides carinii. | despite centuries of therapeutic use, the mechanism of action of arsenicals against various diseases remains unknown. because of the known inhibition of sulfhydryl-containing enzymes by arsenicals, we investigated the possibility that the anti-filarial effects of arsenical drugs might be exerted specifically through impairment of parasite thiol metabolism. we find: (1) arsenicals readily inhibit glutathione reductase of litomosoides carinii but have little effect upon mammalian enzyme. (2) admin ... | 1983 | 6669159 |
| biochemical changes in latent litomosoides carinii infection in rats. | | 1983 | 6674167 |
| time courses of antibody levels in mastomys natalensis after infections with litomosoides carinii, dipetalonema viteae, brugia malayi or b. pahangi, determined by elisa. | using a litomosoides carinii adult antigen, time courses of antibody levels were followed by an elisa in l. carinii, dipetalonema viteae, brugia malayi and b. pahangi infected mastomys natalensis. using various groups of infected animals, periods up to 400 days after infection were covered. in l. carinii infected mastomys, antibodies were first detected 11 days p.i. and levels increased rapidly until day 40. temporarily reduced levels about the beginning of patency were followed by increasing va ... | 1983 | 6685415 |
| effects of amoscanate on the utilization of glucose by brugia pahangi and litomosoides carinii. | | 1984 | 6737169 |
| synthesis of potential antifilarial agents. 1-(5-benzoylbenzimidazol-2-yl)-3-alkyl- and -arylureas. | a series of 1-(5-benzoylbenzimidazol-2-yl)-3-substituted ureas have been synthesized by reacting an appropriate isocyanate with 2-amino-5-benzoylbenzimidazole or by reacting methyl (5-benzoylbenzimidazol-2-yl)carbamate with various amines. several of the compounds have demonstrated antifilarial activity against brugia pahangi and litomosoides carinii. | 1984 | 6737434 |
| litomosoides carinii in jirds (meriones unguiculatus): ability to retard development of challenge larvae can be transferred with cells and serum. | to test the ability of cells and/or serum from jirds (meriones unguiculatus) infected with litomosoides carinii to transfer the ability to retard development of challenge larvae, a series of transfer experiments were done. groups of jirds received larval challenge preceded by one of eight preparations: spleen cells and/or serum from 10-day-patent infected jirds; normal spleen cells and/or normal serum; primary larvae; challenge larvae only. no significant differences in size or numbers of larvae ... | 1984 | 6747255 |
| vitamin a deficiency and the development of litomosoides carinii (nematoda, filarioidea) in cotton rats. | this paper demonstrates that vitamin a deficient (a-) cotton rats are more susceptible to infection with litomosoides carinii than normal (a+) cotton rats. however, embryogenesis is frequently retarded in female worms from a- hosts. groups of young cotton rats were depleted of their liver stores of vitamin a by feeding them a vitamin a free diet from weaning. from 6 weeks of age this diet was supplemented with either 2, 5, 10, 25 or 100 iu vitamin a per 100 g body weight per day and half the ani ... | 1982 | 6753388 |
| [suppression of parasitemia in rodent filariasis (litomosoides carinii) by immunization with bcg and microfilaria. i. intracutaneous inoculation of bcg]. | after intracutaneous inoculation of bcg and challenge by subcutaneous injection of infective larvae of litomosoides carinii, the parasitaemia of the filarial infection in cotton rats remains significantly lower when bcg and larvae are applied in the region of the same popliteal and ileal lymph nodes. however, when the infective larvae are directed to other regional lymph nodes (ln cubitales and axillares), the depression of microfilaraemia is missed. the worm load (recovery rate) and the expulsi ... | 1982 | 6753389 |
| effect of dec on the immune status in rats infected with litomosoides carinii by intraperitoneal transplantation. | | 1982 | 6757121 |
| the host-parasite relationships in normal and protein-malnourished cotton rats infected with litomosoides carinii (nematoda: filarioidea). | a total of 120 young cotton rats were fed ad libitum for 10 weeks on either synthetic diets containing 2.5, 5, 10 or 15% casein or on a stock breeding diet containing 20% crude protein. half of the animals in each group were infected with the filarial nematode litomosoides carinii and the food intake and body weight of each animal was measured. there was a trend towards increased food consumption in protein-deficient cotton rats and this was increased further in infected animals; however, differ ... | 1982 | 6757846 |
| detection of antibodies in brugia pahangi-infected cats by counter immunoelectrophoresis, indirect fluorescent antibody test and enzyme-linked immunosorbent assay. | in cats infected with brugia pahangi, antibodies first appeared against the larvae (l3), then against the adults (l5) and the microfilariae (mf). homologous antigens were better than antigens prepared from heterologous species (dirofilaria immitis, dipetalonema viteae, litomosoides carinii and onchocerca gutturosa) in detecting antibodies to b. pahangi in the infected cats by indirect fluorescent antibody test (ifat). metabolic products of l5, but not l3 or mf, of b. pahangi were antigenic and w ... | 1982 | 6760573 |
| studies on acquired resistance of the cotton rat against microfilariae of litomosoides carinii. 2. injection of microfilariae during prepatency. | cotton rats infected by infective third-stage larvae of litomosoides carinii were treated at increasing time intervals by a threefold injection of living homologous microfilariae (mf) during the prepatent period. starting with the first treatment 3, 4 or 5 weeks p.i. seven animals remained completely and two almost mf-negative (1 or 2 mf/mm3 each only once) until 16 weeks p.i. starting 6, 7 or 8 weeks p.i. six animals developed a normal level of parasitaemia between 42 and 436 mf/mm3, two animal ... | 1982 | 6760574 |
| the development of normal and gamma-irradiated litomosoides carinii larvae in cotton rats. | the development of infective, stage 3 larvae of litomosoides carinii irradiated at either 2.7, 5.4, 10.8, 16.2, 21.6 or 40 krads in a cobalt 60 source was compared with that of normal larvae following injection into cotton rats. worm recovery decreased as the radiation dose increased, male worms being more affected than female worms. worms developing from irradiated larvae were shorter than normal and at 16.2 krads and above they failed to develop into adults despite reaching the pleural cavity ... | 1982 | 6761914 |
| litomosoides carinii infection in cotton-rats before and after treatment with diethylcarbamazine and suramin: evolution of free serum antigens. | immunoelectrodiffusion was used to detect free serum antigens after treatment with diethylcarbamazine (dec) and suramin (s) in 30 cotton-rats infected with litomosoides carinii. precipitin lines between an antiserum produced by an adult worm extract and the test serum indicated the presence of free antigens in the serum. the number of precipitin lines was between one and 3. before treatment only 13.3% of infected rats were positive compared with 83.7% after treatment. there was a difference in t ... | 1982 | 6763787 |
| the effect of levamisole on glycogen synthase and the metabolism of litomosoides carinii. | the effects of the anthelmintic drug, levamisole, on glycogen metabolism in the adult filariid, litomosoides carinii, were examined. incubation of helminths for up to 6 hr in the presence of levamisole resulted in a fourfold increase in total worm glycogen levels. in accord with this observation, levamisole also produced an eightfold increase in the rate of incorporation of [14c]-glucose into [14c]-glycogen over a 6-hr incubation period. in contrast, levamisole had no significant effect on 14co2 ... | 1982 | 6804612 |
| biochemical changes at different stages of litomosoides carinii infection in albino rats. | | 1983 | 6874013 |