| infections in hairy cell leukemia (leukemic reticuloendotheliosis). | of 22 patients with hairy cell leukemia, 18 developed life-threatening infections. susceptibility to infection appeared to be increased nonspecifically, in that a wide range of infecting organisms were noted. pseudomonas aeruginosa was the organism isolated most frequently. four patients had disseminated mycobacterium kansasii, and one had bacillus calmette-guerin lymphadenitis. two patients developed serious fungal infections (candida albicans in one and allescheria boydii in the other). one pa ... | 1981 | 7226028 |
| pseudallescheria boydii keratomycosis in a horse. | the fungal organism pseudallescheria boydii was isolated from the cornea of a quarter horse with ulcerative keratitis. despite aggressive hourly medication through a subpalpebral lavage system, with drugs including miconazole and natamycin, the cornea developed a stromal abscess. orbital exenteration was performed after 3 weeks. the fungal isolate was later determined to be resistant to all 8 antifungal drugs tested. microscopic examination of the cornea revealed fungal hyphae throughout the cor ... | 1989 | 2777709 |
| porcine abortions associated with fungi, actinomycetes, and rhodococcus sp. | history, lesions, and results of microbiologic examinations are given for four porcine abortions associated with fungi and one each associated with actinomadura madurae, an aerobic actinomycete, and rhodococcus sp. the fungi were gliomastix sp., petriellidium boydii, aspergillus fumigatus, and exophiala jeanselmei. parvovirus, isolated from one fetus, was the only other infectious agent identified. the presence of fungi, actinomadura madurae, and rhodococcus sp. in fetal and placental lesions in ... | 1981 | 7281459 |
| a survey of fungi and some indicator bacteria in chlorinated water of indoor public swimming pools. | fifty-four water samples, of volume 500 ml, originating from six public indoor fresh water swimming pools were examined for the presence of fungi and some indicator bacteria by a membrane-filter method. sabouraud-dextrose agar and selective candida albicans-medium were used for isolation and identification of fungi. in all but one of the samples the free chlorine content was above 0.40 mg/l. no candida albicans were detected. molds and unidentified yeasts were isolated from 29 of the samples. th ... | 1981 | 7304014 |
| susceptibility of zoopathogenic fungi to phytoalexins. | phytoalexins are a group of low-molecular-weight antibiotics produced by higher plants in response to infection by relatively avirulent microorganisms. they are of relatively low toxicity for mammalian cells and have been reported to possess a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. employing a broth dilution technique, we have found the zoopathogens petriellidium boydii, aspergillus flavus, a. fumigatus, candida albicans, coccidioides immitis, crypto ... | 1980 | 7387136 |
| annellated conidiogenous cells in petriellidium boydii (scedosporium apiospermum). | annellated conidiogenous cells of both the mononematous (scedosporium state) and synnematous (graphium state) conidiophores develop in the conidial state of petriellidium (= allescheria) boydii, scedosporium (= monosporium) apiospermum. conidiogenesis in this species is characterized by percurrent proliferation of the conidiogenous cells and the conidia are holoblastic and annellidic. | 1980 | 7455859 |
| invasive aspergillosis diagnosed by immunohistochemistry with monoclonal and polyclonal reagents. | therapies differ for invasive infection due to the various filamentous fungi. however, histopathologic identification of aspergillus, pseudallescheria, fusarium, trichosporon, dematiacious hyphomycetes, candida, and zygomycetes may be confused, and microbiologic isolation is often delayed. to improve diagnosis, we examined the utility of polyclonal and monoclonal antibodies to identify aspergillus organisms by peroxidase immunohistochemical techniques. tissues obtained from 68 infected patients ... | 1987 | 3308679 |
| eumycotic mycetoma: review and report of a cutaneous lesion caused by pseudallescheria boydii in a horse. | a cutaneous mass (1.5 cm in diameter) was removed from the head of a horse and was diagnosed histologically as eumycotic mycetoma. immunofluorescence, performed on formalin-fixed, paraffin-embedded tissue, identified pseudallescheria boydii as the etiologic agent. findings from earlier reports of eumycotic mycetoma were compared with those of this horse. | 1987 | 3319985 |
| pseudallescheria boydii brain abscess. complication of an intravenous catheter. | an adult patient survived a brain abscess with pseudallescheria boydii. she received intraventricular miconazole, 20 mg every 72 hours (minimal inhibitory concentration = 0.4 microgram/ml), and surgery. the abscess resulted from an infected central venous catheter (port-a-cath) and steroid therapy. miconazole caused a ventriculitis. there are 12 reported cases of p. boydii brain abscesses from 1965 to 1985 with only two survivors. | 1988 | 3407662 |
| pseudallescheria boydii infection of the central nervous system in a cardiac transplant recipient. | we have described a cardiac transplant recipient with fatal pseudallescheria boydii infection of the central nervous system. unusual features included meningitis without brain abscess and noncommunicating hydrocephalus due to exuberant growth of the organism in the ventricular fluid. long-term amphotericin b administration may have played a role in the development of this infection. | 1986 | 3513333 |
| disseminated opportunistic fungal disease in dogs: 10 cases (1982-1990). | medical records of 10 dogs in which fungal infection was diagnosed between 1982 and 1990 were reviewed. in each dog, infection was determined to be caused by a single species of fungus, either aspergillus terreus, penicillium sp, paecilomyces sp, chrysosporium sp, or pseudallescheria boydii. nine dogs were german shepherd dogs; 1 was a german shepherd dog cross, and 9 were females. the most common clinical signs were signs of neck or back pain (9 dogs), weight loss (7 dogs), anorexia (6 dogs), p ... | 1995 | 7601696 |
| effect of increasing inoculum sizes of pathogenic filamentous fungi on mics of antifungal agents by broth microdilution method. | inoculum size is a critical variable in development of methods for antifungal susceptibility testing for filamentous fungi. in order to investigate the influence of different inoculum sizes on mics of amphotericin b, 5-fluorocytosine, itraconazole, and miconazole, 32 clinical isolates (8 aspergillus fumigatus, 8 aspergillus flavus, 5 rhizopus arrhizus, 8 pseudallescheria boydii, and 3 fusarium solani isolates) were studied by the broth microdilution method. four inoculum sizes were studied: 1 x ... | 1995 | 7615745 |
| multiple mycetomas due to pseudallescheria boydii. | a patient with pulmonary sarcoidosis had evaluation of hemoptysis. a ct scan of the chest showed bilateral upper lobe cavities and five separate mycetomas with air-crescent signs. bronchial washings were positive on stains for fungal elements, and all cultures grew pseudallescheria boydii. we have not seen a previous report of multiple fungus balls due to p boydii demonstrated by chest ct. | 1987 | 3576275 |
| leucocyte chemotaxis to mycetoma agents--the effect of the antifungal drugs griseofulvin and ketoconazole. | polymorphonuclear leucocytes are the predominant cell type in the inflammatory infiltrate around mycetoma grains. human leucocyte chemotaxis using cells from healthy subjects has been demonstrated using cytoplasmic antigens from 3 mycetoma agents: madurella mycetomatis and pseudallescheria boydii, both fungi, and streptomyces somaliensis, an actinomycete. there was a statistically insignificant increase in chemotaxis in the presence of ketoconazole, but griseofulvin was a potent inhibitor of leu ... | 1987 | 3617197 |
| in vitro antifungal and fungicidal spectra of a new pradimicin derivative, bms-181184. | a new pradimicin derivative, bms-181184, was compared with amphotericin b and fluconazole against 249 strains from 35 fungal species to determine its antifungal spectrum. antifungal testing was performed by the broth macrodilution reference method recommended by the national committee for clinical laboratory standards (document m27-p, 1992). bms-181184 mics for 97% of the 167 strains of candida spp., cryptococcus neoformans, torulopsis glabrata, and rhodotorula spp. tested were < or = 8 microgra ... | 1995 | 7726485 |
| comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi. | the purpose of the study was to evaluate the interlaboratory agreement of broth dilution susceptibility methods for five species of conidium-forming (size range, 2 to 7 microns) filamentous fungi. the methods used included both macro- and microdilution methods that were adaptations of the proposed reference method of the national committee for clinical laboratory standards for yeasts (m27-p). the mics of amphotericin b, fluconazole, itraconazole, miconazole, and ketoconazole were determined in s ... | 1995 | 7726488 |
| [epidemiologic study of mycetomas in mexico. apropos of 502 cases]. | the epidemiological data of 502 mycetomas studied in the department of mycology, "centro dermatológico pascua", mexico city, were analysed. mycetomas prevail in males (79.7%), they are more frequent between 16 and 45 years of age (75%) and among rural workers (62.5%); they preferentially affect lower limbs (62.5%); these data are generally similar to the known publications on the matter. actinomycetomas are the most frequent with 97.2% of the cases, distributed as follows: nocardia: 85.6% among ... | 1987 | 3621395 |
| pseudoallescheria boydii soft tissue abscess. | pseudoallescheria boydii, a fungus often isolated from soil, commonly causes a mycetoma. successful treatment involves resection of the infected area and appropriate antifungal chemotherapy. in vitro sensitivity of p. boydii to miconazole is usually demonstrated, but resistance to amphotericin b and 5-fluorocytosine is often observed. limited data are available on the treatment of this infection with ketoconazole. an usual case of nontraumatic p. boydii soft tissue infection without draining sin ... | 1987 | 3802640 |
| miconazole therapy in pseudallescheria boydii infection. | | 1985 | 3835956 |
| phylogeny of dermatophytes and dimorphic fungi based on large subunit ribosomal rna sequence comparisons. | the phylogeny of dermatophytes and dimorphic fungi was considered using the large-subunit of ribosomal rna (25s rrna). aligned sequences of 595 nucleotides covering the two most divergent domains d1 and d2, permitted a comparison of phylogenetic relationships at different levels. the dimorphic species (onygenaceae) were significantly separated from dermatophytes (arthrodermataceae) and from a third group including geophilic or very weakly pathogenic species (onygenaceae and gymnoascaceae). on a ... | 1994 | 7844699 |
| ecology and physiology of the emerging opportunistic fungi pseudallescheria boydii and scedosporium prolificans. | nutritionally physiological patterns of pseudallescheria boydii (microascaceae) and the related species scedosporium prolificans were established. differences between the two species were found in assimilation of sucrose, ribitol, xylitol and l-arabinitol. in contrast, no physiological distinction could be made between the three intraspecific variants of p. boydii which have been recognized on the basis of ndna/dna homology data and of morphological and clinical differences. some potential virul ... | 1994 | 7845423 |
| prevalence of fungal corneal ulcers in northern india. | fungal corneal ulcer is common in india due to the tropical climate and a large agrarian population that is at risk. various factors such as trauma, the injudicious use of topical antibiotics and corticosteroids are involved. many of the age and sex-related risk factors also play a minor role. this 6-year study from northern india revealed that fungi were detected in 61 (8.4%) out of 730 patients investigated. direct microscopy was positive in 51 (7%) and culture in 53 (7.3%) patients. aspergill ... | 1994 | 7927819 |
| fungal panophthalmitis secondary to scedosporium apiospermum (pseudallescheria boydii) keratitis. | | 1994 | 7943139 |
| post-craniotomy wound infection caused by pseudallescheria boydii. case report. | the authors describe the first reported case of post-craniotomy wound infection due to pseudallescheria boydii. the patient was a 24-year-old man who sustained a direct blunt injury to the calvaria, resulting in a large subdural hematoma that was surgically evacuated. subsequently, the surgical wound became infected with a fungus, p. boydii, and was successfully treated with intravenous miconazole. | 1986 | 3941340 |
| subcutaneous pseudallescheriasis in a renal transplant recipient. | this paper reports a case of a single subcutaneous nodule caused by pseudallescheria boydii in a renal transplant recipient, possibly of nontraumatic origin. the patient was treated surgically and with itraconazole. | 1994 | 8047106 |
| [pseudallescheria boydii fungal endophthalmitis. 6 years after trabeculectomy]. | a case is reported of a 67-year-old female patient, in whom a fungal endophthalmitis occurred 6 years after trabeculectomy. pseudallescheria boydii was isolated. this organism is a rare cause of infection. in the literature only 14 cases of keratitis and 8 cases of endophthalmitis have been reported. miconazole is the therapy of choice. however in 55% of the published cases, (as in the one reported here), an exenteration or enucleation of the affected bulbus was necessary. | 1994 | 8051902 |
| case report: prosthetic valve endocarditis caused by pseudallescheria boydii and clostridium limosum. | this report describes a patient with a combined infection due to pseudallescheria boydii and clostridium limosum on a prosthetic dura mater aortic valve homograft. while this patient had c. limosum only growing in blood cultures, both organisms were isolated from the surgically resected aortic valve. because p. boydii is generally resistant to amphotericin b but susceptible to miconazole, accurate differentiation of p. boydii from other fungi which may appear similarly in tissue sections (e.g., ... | 1985 | 3990765 |
| an additional case of pulmonary pseudallescheria boydii improved with ketoconazole therapy. | | 1985 | 3996080 |
| brain abscesses due to pseudallescheria boydii associated with primary non-hodgkin's lymphoma of the central nervous system: a case report and literature review. | a 54-year-old man with primary non-hodgkin's lymphoma of the thoracic spinal cord developed multiple brain abscesses caused by pseudallescheria boydii. the patient had received radiotherapy and corticosteroid treatment before developing the brain abscesses. antemortem diagnostic evaluations were inconclusive, and diagnosis was finally made from postmortem brain specimens by the use of histologic examination and isolation of the fungus in culture. the portal of entry for the organism was unknown, ... | 1985 | 4001716 |
| conidiogenesis in petriellidium boydii (pseudallescheria boydii). a light and electron microscope study. | slide cultures of the type strain of p. boydii shear, showed percurrent production of conidia by light microscopy over a period of several hours. scanning and transmission electron microscopy were used to examine the conidiogenesis. the conidiogenous cells developed annular ridges rather than typical annellophoric scars. evidence that these ridges represented sequential spore production was shown by t.e.m. in the form of a discontinuity of the outer conidiophore wall at the widest point of each ... | 1982 | 7121559 |
| non-aspergillus aspergilloma. | a case of lung cavity with fungus ball is reported in a patient subsequent to the treatment of tuberculosis for a year. fungal serologic titers for histoplasmin, blastomycin, coccidiodin, and aspergillin were negative. surgical resection of the cavity and to be done because of episodes of hemoptysis. numerous hyphae formed into a compact mass consistent with aspergilloma were seen in the cavity. the cultures for fungi were negative on material from the surgical specimen. immunodiffusion studies ... | 1982 | 7148753 |
| pseudallescheria boydii infection after bone marrow transplantation. | | 1983 | 6309050 |
| severe corneoscleral infection. a complication of beta irradiation scleral necrosis following pterygium excision. | to assess the precipitating factors, clinical course, and treatment of 11 cases of severe intraocular infections of radionecrosis after pterygium excision in an attempt to minimize the devastating ocular sequelae. | 1993 | 8328937 |
| allergic bronchopulmonary mycosis caused by pseudallescheria boydii. | two cases of allergic bronchopulmonary pseudallescheriosis (abpp) are described. these are the first cases of this allergic bronchopulmonary mycosis (abpm) reported in which the clinical and serologic criteria are described. the first case was in a patient with mild asthma, and it resolved spontaneously after expectoration of a mucous plug. the second was in a patient with recurrent allergic bronchopulmonary aspergillosis with an exacerbation of abpm caused by pseudallescheria boydii. the total ... | 1993 | 8368653 |
| brain abscess due to petriellidium boydii. | a 22 year-old man died from multiple cerebral abscesses due to petriellidium boydii 4 1/2 months after an episode of near drowning. the autopsy showed dissemination to heart and kidney. this patient had no immunocompromising disease but was treated with corticosteroids. the treatment of this condition with ventricular shunting and amphotericin b is discussed and compared with the experience of ten other cases reported in the literature. | 1984 | 6467093 |
| osteomyelitis due to pseudallescheria boydii. | this report describes an unusual opportunistic fungal infection in an immunocompetent young man who had no cutaneous involvement and whose infection was diagnosed 6 years after an accident. the unusual clinical presentation and difficulties in making a correct diagnosis are discussed and prophylactic antifungal chemotherapy is suggested. | 1993 | 8434301 |
| fungal sinusitis in healthy and immunocompromised individuals. | clinical and microbiologic aspects of fungal sinusitis occurring in six patients are presented. three of the six patients were immunosuppressed. fatal disseminated fungal disease developed in two of those immunosuppressed. the three patients with normal immune function had fungal infections confined to the nasal sinuses. aspergillus fumigatus and aspergillus flavus were recovered from the immunosuppressed patients and sporothrix schenckii, alternaria species, and pseudallescheria boydii were rec ... | 1984 | 6496403 |
| pulmonary, cardiac, and thyroid involvement in disseminated pseudallescheria boydii. | | 1984 | 6548359 |
| molecular probes for diagnosis of fungal infections. | we have developed 21 specific nucleic acid probes which target the large subunit rrna genes from aspergillus flavus, aspergillus fumigatus, aspergillus glaucus, aspergillus niger, aspergillus terreus, blastomyces dermatitidis, candida albicans, candida (torulopsis) glabrata, candida guilliermondii, candida kefyr, candida krusei, candida lusitaniae, candida parapsilosis, candida tropicalis, coccidioides immitis, cryptococcus neoformans var. gattii, cryptococcus neoformans var. neoformans, filobas ... | 1995 | 8576345 |
| pcr and single-strand conformational polymorphism for recognition of medically important opportunistic fungi. | the application of pcr technology to molecular diagnostics holds great promise for the early identification of medically important pathogens. pcr has been shown to be useful for the detection of the presence of fungal dna in both laboratory and clinical samples. considerable interest has been focused on the utility of selecting universal primers, those that recognize constant regions among most, if not all, medically important fungi. once an amplicon, or piece of amplified dna determined by the ... | 1995 | 8586705 |
| the histopathological features of pale grain eumycetoma. | histological findings in 24 cases of pale grain eumycetoma have been compared. the inflammatory response and morphology of grains caused by different organisms are very similar. however the histological appearances of neotestudina rosatii infections, although reminiscent of dermatophyte mycetomas, are distinctive. the characteristic features include the presence of cement and the short swollen hyphal segments. petriellidium boydii grains are more likely to contain numerous vesicles or swollen hy ... | 1982 | 7164152 |
| cerebral pseudallescheria mycosis after near-drowning. | scedosporium apiospermum, an anamorph of pseudallescheria boydii, is a hyalohyphomycete which can be mistaken, histologically, for aspergillus. s. apiospermum is clinically distinguished by resistance to most antifungals and its ability to cause invasive mycoses in immunocompetent patients. here we present a typical case of lethal cerebral pseudallescheria mycosis in a child after near-drowning. | 1995 | 8720198 |
| pseudallescheria boydii in a patient with acute lymphoblastic leukemia. | pseudallescheria boydii, a common soil organism, is best known as the causative agent of mycetoma. isolation of the organism from sites other than the extremities is relatively uncommon. however, the use of corticosteroids and cancer chemotherapy has been associated with an increasing frequency of localized superinfection as well as disseminated disease. recently, an increased number of disseminated p boydii infections, primarily associated with immunosuppressed patients, has been reported in th ... | 1984 | 6588928 |
| fatal pseudallescheria boydii panencephalitis in a child after near-drowning. | | 1996 | 8866809 |
| scedosporium apiospermum pneumonia after autologous bone marrow transplantation. | although opportunistic infections after bone marrow transplantation (bmt) are very common, only five cases of pseudallescheria boydii infection have been reported in the literature, two of which were autopsy findings. a case of scedosporium apiospermum infection after bmt, treated initially with amphotericin b (total dose of 2.5 g) and then with itraconazole (for 25 days), is reported here. when the patient failed to improve, scedosporium apiospermum pneumonia was diagnosed and therapy was chang ... | 1996 | 8874080 |
| human sex hormones stimulate the growth and maturation of coccidioides immitis. | because men and pregnant women show increased susceptibility to extrapulmonary dissemination of coccidioidomycosis, studies were conducted to determine the direct effect of human sex hormones and related compounds on the growth and maturation of coccidioides immitis in vitro. 17 beta-estradiol, progesterone, and testosterone were highly stimulatory for the parasitic phase of c. immitis growth whereas cholesterol, ergosterol, and 17 alpha-estradiol (a physiologically inactive stereoisomer of 17 b ... | 1981 | 7251153 |
| immunoperoxidase staining for identification of aspergillus species in routinely processed tissue sections. | to evaluate the performance of an immunoperoxidase stain using the monoclonal antibody eb-a1 to detect aspergillus species in formalin fixed, paraffin wax embedded tissue. | 1996 | 8943743 |
| multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi. | a multicenter study was conducted to expand the generation and analysis of data that supports the proposal of a reference method for the antifungal susceptibility testing of filamentous fungi. broth microdilution mics of amphotericin b and itraconazole were determined in 11 centers against 30 coded duplicate pairs of aspergillus spp., fusarium spp., pseudallescheria boydii, and rhizopus arrhizus. the effect of inoculum density (approximately 10(3) and 10(4) cfu/ml), incubation time (24, 48, and ... | 1997 | 8968895 |
| development of maduromycosis (madurella mycetomi) after nailing of a closed tibial fracture: a case report. | maduromycosis is a rare fungal infection in the northern united states, most frequently caused by allescheria boydii, usually in debilitated or immunosuppressed patients. an 18-year-old mexican-american, in excellent health, developed multiple draining sinuses at the sites of insertion of ender nails for a closed tibial fracture. madurella mycetomi was cultured from black granules in a biopsy specimen. the source of fungal infection remained unknown, although it probably did not occur during the ... | 1981 | 7471560 |
| an ultrastructural study of pale eumycetoma grains. | the electron microscopic appearances of grains from seven patients with pale grain eumycetoma infections have been studied. the infecting fungi were pseudallescheria boydii (2), fusarium sp. (1), acremonium kiliense (1), a non-sporing mould (2) and trichophyton violaceum (1). p. boydii grown in vitro and grains from a madurella mycetomatis infection were used for comparison. the most important ultrastructural features of the pale eumycetoma grains were the gross thickening of the fungal cell wal ... | 1983 | 6686344 |
| [maduromycotic mycetoma in a horse]. | a case of maduromycotic mycetoma (eumycetoma) in seven years old draught horse is described. the disease was localized in anal region and healed after surgical treatment. attention is drawn to the necessity of distinguishing three types of mycosis in horses, characterized by the origin of tumor lesions - mycetomas, hyphomycosis and entomophthoromycosis - and information was gathered on their etiology and geographical occurrence. on the basis of the morphology of fungal elements traced in inflamm ... | 1982 | 6801842 |
| risk of reactivation of a recent invasive fungal infection in patients with hematological malignancies undergoing further intensive chemo-radiotherapy. a single-center experience and review of the literature. | patients with hematologic malignancies and a history of an invasive fungal infection are considered to be at high risk of suffering reactivation of the infection during subsequent intensive chemotherapy. | 1997 | 9234575 |
| infectious posterior scleritis caused by pseudallescheria boydii. clinicopathologic findings. | the purpose of the study is to describe an unusual case of infectious posterior scleritis after excision of a pterygium. | 1997 | 9261319 |
| immunohistologic identification of aspergillus spp. and other hyaline fungi by using polyclonal fluorescent antibodies. | isolation and identification of pathogenic aspergillus and fusarium spp. from clinical materials provide the most accurate means for establishing a diagnosis of infections by these molds. such efforts, however, are not always successful. histologic diagnosis also has its limitations. in vivo the hyphae of aspergillus and fusarium spp. are very similar and their in situ manifestations are not pathognomonic. to improve the histologic diagnosis of infections by aspergillus and fusarium species, we ... | 1997 | 9276388 |
| sulconazole in the therapy of dermatomycoses in nigeria. | a 1% cream of sulconazole nitrate, an imidazole derivative, was used to treat 38 patients with diverse clinical types of dermatomycoses, including 16 cases of pityriasis versicolor, 14 of dermatophytosis (tinea pedis, tinea cruris, tinea corporis), two of balanoposthitis due to candida albicans, another two of candidosis of the groin, one each of groin and foot infection due to trichosporon beigelii and one case each of lesions of the hand and trunk caused by petriellidium boydii and scytalidium ... | 1997 | 9375503 |
| pale grain eumycetomas in madras. | biopsy specimens from 211 cases of mycetoma were examined histologically. pale grain eumycetoma was found in seven cases. four of these were studied mycologically, acremonium kiliense was isolated from two and acremonium falciforme and pseudallescheria boydii from one case each. the geographic distribution of these organisms, and their incidence and prevalence are discussed. | 1995 | 7487741 |
| in vitro activity of the new triazole voriconazole (uk-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens. | the in vitro antifungal activity of a new triazole derivative, voriconazole, was compared with those of itraconazole and amphotericin b against 67 isolates of aspergillus flavus, aspergillus fumigatus, bipolaris spp., fusarium oxysporum, fusarium solani, pseudallescheria boydii, rhizopus arrhizus, blastomyces dermatitidis, histoplasma capsulatum, and sporothrix schenckii. the in vitro activities of voriconazole were also compared with those of amphotericin b, fluconazole, and itraconazole agains ... | 1998 | 9431946 |
| evaluation of possible correlations between antifungal susceptibilities of filamentous fungi in vitro and antifungal treatment outcomes in animal infection models. | nine isolates of filamentous fungi previously tested in 11 different laboratories for their susceptibilities to amphotericin b and itraconazole in vitro were injected intravenously into mice and guinea pigs, and responses to treatment with both agents were studied. the experiments were done in a single laboratory. mean survival times, the percentages of animals surviving 12 days after infection, and culture results for samples of deep organs obtained postmortem were used as markers of antifungal ... | 1998 | 9527773 |
| in vitro activity of a new oral triazole, bms-207147 (er-30346) | the antifungal activity of bms-207147 (also known as er-30346) was compared to those of itraconazole and fluconazole against 250 strains of fungi representing 44 fungal species. mics were determined by using the national committee for clinical laboratory standards (nccls)-recommended broth macrodilution method for yeasts, which was modified for filamentous fungi. bms-207147 was about two- to fourfold more potent than itraconazole and about 40-fold more active than fluconazole against yeasts. wit ... | 1998 | 9527778 |
| scedosporium apiospermum (pseudallescheria boydii) infection in a heart transplant recipient: a case of mistaken identity. | we report a case of fatal central nervous system infection with scedosporium apiospermum (pseudallescheria boydii) in a heart transplant recipient. this ubiquitous fungus is known to cause mycetoma and localized infections in patients with otherwise normal conditions. disseminated infections occur rarely and are seen primarily in patients who are receiving immunosuppressive medications or who have neutropenia. often life-threatening when infection is disseminated and involves the central nervous ... | 1998 | 9563611 |
| in vitro activity of two echinocandin derivatives, ly303366 and mk-0991 (l-743,792), against clinical isolates of aspergillus, fusarium, rhizopus, and other filamentous fungi. | ly303366 and mk-0991 (previously l-743,792) are new echinocandin derivatives with excellent broad-spectrum antifungal activity. we investigated the in vitro activity of ly303366, mk-0991, itraconazole, amnphotericin b, and 5-flucytosine against 51 clinical isolates of filamentous fungi, including aspergillus flavus (10), a. fumigatus (12), fusarium spp. (13), rhizopus spp. (6), pseudallescheria boydii (5), and one isolate each of acremonium spp., a. niger, a terreus, paecilomyces spp., and trich ... | 1998 | 9582584 |
| activities of amphotericin b and antifungal azoles alone and in combination against pseudallescheria boydii. | in order to develop new approaches to treatment of infections due to pseudallescheria boydii, the in vitro antifungal activity of amphotericin b alone and in combination with miconazole, itraconazole, and fluconazole was studied. combinations of amphotericin b and antifungal azoles were synergistic, additive, or indifferent in their interaction against p. boydii. antagonism was not observed. | 1995 | 7574531 |
| rapid extraction of genomic dna from medically important yeasts and filamentous fungi by high-speed cell disruption. | current methods of dna extraction from different fungal pathogens are often time-consuming and require the use of toxic chemicals. dna isolation from some fungal organisms is difficult due to cell walls or capsules that are not readily susceptible to lysis. we therefore investigated a new and rapid dna isolation method using high-speed cell disruption (hscd) incorporating chaotropic reagents and lysing matrices in comparison to standard phenol-chloroform (pc) extraction protocols for isolation o ... | 1998 | 9620390 |
| cerebral pseudallescheriasis due to pseudallescheria boydii as the first manifestation of aids. | | 1998 | 9636891 |
| comparison of in vitro activities of the new triazole sch56592 and the echinocandins mk-0991 (l-743,872) and ly303366 against opportunistic filamentous and dimorphic fungi and yeasts. | the in vitro antifungal activities of sch56592, mk-0991, and ly303366 against 83 isolates of acremonium strictum, aspergillus flavus, aspergillus fumigatus, aspergillus terreus, bipolaris spp., blastomyces dermatitidis, cladophialophora bantiana, fusarium oxysporum, fusarium solani, histoplasma capsulatum, phialophora spp., pseudallescheria boydii, rhizopus arrhizus, scedosporium prolificans, and sporothrix schenckii were compared. the in vitro activities of these agents against 104 isolates of ... | 1998 | 9738049 |
| chronic hemoptysis: an unusual manifestation of fungal sinusitis. | a woman with chronic hemoptysis as her only complaint had extensive testing and did not respond to antibiotic therapy. radiologic examination of the sinuses identified a mass which, on surgical exploration, was found to be the result of a fungus, pseudallescheria boydii. although this fungus is known to be a cause of epistaxis, this is the first instance in which it has been reported to cause hemoptysis. | 1995 | 7597490 |
| in vitro activity of a new triazole antifungal agent, sch 56592, against clinical isolates of filamentous fungi. | sch 56592 is a new triazole derivative that possesses potent, broad-spectrum antifungal activity. we evaluated the in vitro activity of sch 56592 compared with that of itraconazole, amphotericin b and 5-fluorocytosine against 51 clinical isolates of filamentous fungi, including aspergillus flavus (10), a. fumigatus (12), fusarium spp. (13), rhizopus spp. (6), pseudallescheria boydii (5), and one isolate each of acremonium spp., a. niger, a. terreus, paecilomyces spp., and trichoderma spp. in vit ... | 1998 | 9750338 |
| invasive pulmonary pseudallesheriosis in a cross-breed calf. | pulmonary pseudallescheriosis was diagnosed in a two-months old calf. pneumonic lungs with yellow-white nodules on the surfaces revealed granulomatous lesions microscopically. septate, pleomorphic hyphae were present in the central caseated core with a bright eosinophilic periphery surrounded by polymorphonuclear cells and macrophages followed by a zone of epithelioid cells admixed with lymphocytes and plasma cells. the fungal agent was demonstrated by grocott's silver methenamine staining. on i ... | 1994 | 7708091 |
| sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, pneumocystis carinii, and filamentous fungi. | gm 193663, gm 211676, gm 222712, and gm 237354 are new semisynthetic derivatives of the sordarin class. the in vitro antifungal activities of gm 193663, gm 211676, gm 222712, and gm 237354 against 111 clinical yeast isolates of candida albicans, candida kefyr, candida glabrata, candida parapsilosis, candida krusei, and cryptococcus neoformans were compared. the in vitro activities of some of these compounds against pneumocystis carinii, 20 isolates each of aspergillus fumigatus and aspergillus f ... | 1998 | 9797217 |
| disseminated cutaneous pseudallescheria boydii. | as increasingly aggressive chemotherapeutic regimens are used to treat malignancy, more patients will become susceptible to various opportunistic pathogens. specifically, several fungal organisms previously viewed as relatively non-pathogenic are more frequently causing serious disease in these patients. identification of these organisms is of paramount importance, as some are relatively resistant to standard antifungal therapies. we report a patient with disseminated cutaneous pseudallescheria ... | 1995 | 7718466 |
| ribosomal dna internal transcribed spacer analysis supports synonomy of scedosporium inflatum and lomentospora prolificans. | scedosporium inflatum is a dematiaceous opportunistic pathogen originally described by d. malloch and i.f. salkin (mycotaxon 21:247-255, 1984). however, e. gueho and g. s. de hoog (j. mycol. med. 118:3-9, 1991) recently suggested reducing this mold to synonomy with lomentospora prolificans on the basis of their similar morphological and molecular characteristics. we have investigated the ribosomal dna internal transcribed spacers (its), i.e., its i and its ii, of 18 isolates, including these two ... | 1994 | 7814476 |
| rapid method for detection of aspergillus 5s ribosomal rna using a genus-specific oligonucleotide probe. | ribosomal rna (rrna) is present in all prokaryotic and eukaryotic cells. although sequences are conserved, variations in nucleic acid composition are known to be species specific. formalin or bouin's fixed, paraffin-embedded tissue specimens from 17 cases of culture proven aspergillus sp infections were studied by a rapid (< 30 minutes) in situ hybridization procedure using a biotinylated oligonucleotide dna probe complementary to nucleic acids 1-22 of aspergillus sp 5s rrna sequence. positivity ... | 1995 | 7817944 |
| invasive pulmonary pseudallescheriasis with direct invasion of the thoracic spine in an immunocompetent patient. | most invasive pseudallescheriasis infections have occurred in immunocompromised patients. the case of an immunocompetent patient with invasive pulmonary pseudallescheriasis and subsequent contiguous extension to the ribs and spine is reported. aspergillosis was mistakenly diagnosed on histopathologic examination of the debrided tissue. culture of the debrided tissue yielded pseudallescheria boydii. | 1994 | 7843180 |
| fungal arthritis due to pseudallescheria boydii (scedosporium apiospermum). | musculoskeletal infections by fungal agents are uncommon conditions. pseudallescheria boydii is an ubiquitous saprophytic fungus frequently involved in maduromycosis but rarely in septic arthritis. we describe a case of pseudallescheria boydii destructive suppurative arthritis and osteomyelitis of the knee in an adult guadeloupean man. osteoarticular infections due to pseudallescheria boydii are reviewed. | 1994 | 8035409 |
| treatment of tropical mycoses. | several subcutaneous and deep-seated mycoses are either observed more frequently in the tropical areas or are restricted to certain regions within the tropics. these mycoses include sporotichosis, chromoblastomycosis, entomophthoromycosis, eumycetoma, lobomycosis, and paracoccidioidomycosis. in sporotrichosis and paracoccidioidomycosis, therapy often results in either complete resolution or marked improvement. for decades sporotrichosis has been treated successfully with potassium iodide, but re ... | 1994 | 8077517 |
| [fungal flora in chicken stalls and its etiopathogenic importance for humans and animals]. | in order to find out the mycoflora prevailing in chicken pens, and to appreciate the health hazards for employees (incl. veterinarians) and animals, twenty litter samples and 6 sedimented dust trials were analysed mycologically. the following results were found: bedding and dust samples all contained between 3.57 and 1.30 x 10(7) c.f.u./g dw. the commonest fungus is a. fumigatus with 3.41 x 10(4) - 1.30 x 10(7) c.f.u./g dw in bedding and 2.70 x 10(5) - 3.30 x 10(6) c.f.u./g dw in sedimented dust ... | 1999 | 10209909 |
| the influence of bacterial inoculants on the microbial ecology of aerobic spoilage of barley silage. | the aerobic decomposition of barley silage treated with two inoculants (laca and lacb) containing mixtures of lactobacillus plantarum and enterococcus faecium was investigated over a 28-day period. initially, yeast and bacterial populations were larger in silage inoculated with laca than in silage treated with lacb or water alone (control). differences in the succession of yeasts in silage treated with laca were observed relative to the other two treatments. from silage treatment with laca, issa ... | 1999 | 10349723 |
| fungal sinusitis in patients with aids: report of 4 cases and review of the literature. | we report here 3 cases of aspergillus sinusitis in patients with aids and the 1st fully described case, to our knowledge, of sinusitis associated with pseudallescheria boydii in a patient with aids. we review the microbiology and pathology of fungal sinusitis in patients with aids and the morphologic and clinical features and treatment of p. boydii infection and aspergillus sinusitis. fungal sinusitis in patients with hiv or aids generally occurs later in the course of primary disease with low c ... | 1994 | 8152366 |
| fungal corneoscleritis complicating beta-irradiation-induced scleral necrosis following pterygium excision. | four cases of fungal corneoscleritis complicating beta-irradiation-induced scleral necrosis after pterygium excision have presented to our institution in recent years. two cases were due to petriellidium boydii and one each to fusarium and scedosporium inflatum. the condition may remain undiagnosed for weeks to months and becomes chronic with perforation or incipient perforation. the infections may masquerade as a chronic red eye, posterior scleritis or serous retinal detachment. penetrating or ... | 1993 | 8253231 |
| [disseminated infection due to scedosporium apiospermum in liver transplantation. differential diagnosis from invasive aspergillosis]. | a case of fatal disseminated infection due to scedosporium apiospermum occurring after liver transplantation is reported. diagnosis was made at autopsy, as numerous fungal colonies were found in the lungs, heart, brain, kidney, spleen and liver. scedosporium apiospermum was identified in pulmonary, cerebral and myocardial specimens by sabouraud's glucose agar cultures. infections due to scedosporium (s. apiospermum ou pseudallescheria boydii) occur in immunocompromised hosts, particularly after ... | 1993 | 8311860 |
| successful treatment of madura foot caused by pseudallescheria boydii with escherichia coli superinfection: a case report. | | 1999 | 10459334 |
| electrotransformation of the human pathogenic fungus scedosporium prolificans mediated by repetitive rdna sequences. | the regions encoding the 5.8s rrna and the flanking internal transcribed spacers (itsi and itsii) from two isolates of the human pathogenic fungus scedosporium prolificans and one isolate of the taxonomically related species pseudallescheria boydii (s. apiospermum) were sequenced. the sequences of the two s. prolificans isolates were identical. however, there were minor differences between both species. phylogenetic analysis of known fungal sequences confirmed a close relationship between s. pro ... | 1999 | 10459582 |
| isolated sphenoid sinusitis due to pseudallescheria boydii. | a case of sphenoid sinusitis due to pseudallescheria boydii is described in a 52-year-old non-immunocompromised woman. treatment should always involve surgical drainage, and antifungal chemotherapy may be of benefit if there is histological evidence of invasion of surrounding tissue. for p. boydii infection miconazole should be the agent of choice, rather than amphotericin b. for this reason it is important to obtain culture and histological examination of sinus contents if fungal infection is s ... | 1993 | 8320525 |
| fungal susceptibility testing. | the utility of antifungal susceptibility testing has not been broadly determined. thus, susceptibility testing of fungal isolates is not recommended on a routine basis. for instance, susceptibilty testing may be considered for some candida species and for patients with pseudallescheria boydii infections. testing of yeasts for susceptiblity to azoles is of particular value due to their variability in response to these agents. it may also be important to test the susceptibility of new fungal organ ... | 1999 | 10571444 |
| in-situ detection of aspergillus fumigatus. | an in-situ hybridisation (ish) technique to detect aspergillus fumigatus in infected tissues was developed in which 568-bp, 333-bp and 154-bp pcr products of the alkaline proteinase gene were employed. dot-blot hybridisation with the 568-bp probe on a membrane containing genomic dna from several different fungi including a. flavus, a. niger, penicillium spp., mucor racemosus or pseudallescheria boydii gave negative results. ish was done on formalin-fixed, paraffin-embedded pulmonary tissues from ... | 2000 | 10707949 |
| antifungal activity of the new azole uk-109, 496 (voriconazole). | the in vitro activity of voriconazole fully includes aspergillus, and also emerging moulds like fusarium, pseudallescheria boydii, and penicillium marneffei. the minimal inhibitory concentrations of voriconazole for candida krusei and candida glabrata, which are resistant or less susceptible to fluconazole, promise clinical efficacy, although they are ten times higher (0.30-0.39 microgram/ml) than those for candida albicans and other candida spp. (0.001-0.05 microgram/ml). the endemic fungal pat ... | 1999 | 10865910 |
| successful treatment of simultaneous pulmonary pseudallescheria boydii and aspergillus terreus infection with oral itraconazole. | pseudallescheria boydii and aspergillus terreus are unusual opportunistic fungal pathogens that are often resistant to chemotherapy with amphotericin b. we report a case of simultaneous invasive pulmonary infection with these organisms occurring in a bone marrow transplant recipient who was successfully treated with the oral azole itraconazole. | 1993 | 8392389 |
| meningitis caused by pseudallescheria boydii treated with voriconazole. | meningitis caused by pseudallescheria boydii is an uncommon infection of the cns that usually has a poor prognosis and a difficult treatment. we describe a case of chronic meningitis caused by p. boydii in an immunocompetent host that was successfully treated with voriconazole, a new antifungal agent. | 2000 | 10880322 |
| recurrent pseudallescheria boydii sinusitis in acute leukemia. | most episodes of fungal sinusitis in immunocompromised patients are caused by aspergillus species. to treat such infections, surgical debridement and anti-fungal therapy have been recommended; it is also clear however that an adequate neutrophil count is important in controlling such infections. we report a case in which fungal sinusitis was shown to be due to p. boydii and in which the infection recurred over a period of 2 years during episodes of neutropenia in spite of vigorous surgical and m ... | 1993 | 8511522 |
| arthritis without grains caused by pseudallescheria boydii. | severe infection of the knee joint by pseudallescheria boydii in a 23-year-old female resulted in complete destruction of the cartilaginous surface. the possibility of entry of the fungus through mild abrasions of unperforated skin is discussed. the clinical appearance is compared with that of scedosporium prolificans. antimycotic miconazole-itraconazole treatment, applied during a period of 4 months, was successful; no side-effects were noted. | 1995 | 8569811 |
| in vitro susceptibility testing of filamentous fungi: comparison of etest and reference microdilution methods for determining itraconazole mics. | the performance of the etest for itraconazole susceptibility testing of 50 isolates of filamentous fungi was assessed in comparison with the national committee for clinical laboratory standards (nccls) proposed standard microdilution broth method. the nccls method employed rpmi 1640 broth medium, and mics were read after incubation for 48 h at 35 degrees c. etest mics were determined with rpmi agar containing 2% glucose and with casitone agar and were read after incubation for 24 h (aspergillus ... | 2000 | 10970383 |
| pseudallescheria boydii infection of the nasal cavity of a horse. | an 18-year-old 454-kg (1,000-lb) american quarter horse gelding was evaluated because of chronic intermittent malodorous right-sided nasal discharge. endoscopy revealed a mycotic plaque in the nasal cavity adjacent to the nasomaxillary opening of the right caudal maxillary sinus. the nasomaxillary opening appeared to be larger than normal. fungal culture of specimens of the mycotic plaque yielded pseudallescheria boydii. the horse was treated with 2% miconazole intranasally, sodium iodide i.v., ... | 2000 | 10976304 |
| pseudallescheria boydii in an immunocompromised host. successful treatment with debridement and itraconazole. | | 1996 | 8629840 |
| fluconazole in the therapy of tropical deep mycoses. | a clinical study was conducted to test the efficacy of fluconazole in the treatment of tropical deep mycoses. two out of four patients with zygomycosis due to conidiobolus coronatus who were treated with the drug were completely cured; the other two patients exhibited considerable improvement but could not be followed up. two patients with eumycetoma, one due to an acremonium sp. and one due to pseudallescheria boydii, were treated successfully, whereas another patient with a eumycetoma caused b ... | 1995 | 8720201 |
| pseudallescheria boydii infection of the brain: imaging with pathologic confirmation. | pseudallescheria boydii is a rare opportunistic microorganism that usually infects immunosuppressed hosts. in this patient with cerebral infection by p boydii, imaging findings included enhancement of the ependyma of a lateral ventricle and of the caudate nucleus. | 1996 | 8881260 |
| mycoflora and mycotoxins in brazilian black pepper, white pepper and brazil nuts. | a wide range of field and storage fungi were isolated from black pepper, white pepper and brazil nut kernels from amazonia. a total of 42 species were isolated from both peppers. aspergillus flavus and a. niger were isolated more frequently from black than from white pepper. other potential mycotoxigenic species isolated included: a. ochraceus, a. tamarii, a. versicolor, emericella nidulans and chaetomium globosum, penicillium brevicompactum, p. citrinum, p. islandicum and p. glabrum. species is ... | 2000 | 11229375 |
| a peptidorhamnomannan from the mycelium of pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen. | the ascomycete pseudallescheria boydii is an emerging human pathogen frequently found in soil and polluted water. a peptidopolysaccharide antigen has been isolated from mycelial forms of p. boydii, and characterized using chemical and immunological methods. monosaccharide composition, methylation analysis, and (1)h- and (13)c-nmr spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing rhap(1-->3)rhap epitop ... | 2001 | 11390680 |
| emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century. | opportunistic fungi have emerged during the past decade as important causes of morbidity and mortality in immunocompromised patients. candida species constitute the third to fourth most common causes of nosocomial blood stream infections, and aspergillus species have emerged as the most common infectious cause of pneumonic mortality in bone marrow/stem cell transplant recipients. among hiv-infected patients, meningoencephalitis due to cryptococcus neoformans ranks among the most common aids-defi ... | 1999 | 11428996 |
| pulmonary tuberculosis associated with invasive pseudallescheriasis. | a 54-year-old woman with pulmonary tuberculosis developed pneumonia caused by scedosporium apiospermum, the asexual stage of the fungus pseudallescheria boydii. mycobacterium tuberculosis and p boydii were cultured in bal fluid. the patient cleaned swimming pools in a spa health resort and was highly exposed to fungal conidia. she was successfully treated with antituberculosis drugs, miconazole nitrate and ketoconazole, leading to remission of her pulmonary infection. invasive pulmonary pseudall ... | 1997 | 9042007 |
| oral terbinafine for treatment of pulmonary pseudallescheria boydii infection refractory to itraconazole therapy. | | 1997 | 9063671 |