| orofacial fungal infections. nine pathogens that may invade during chemotherapy. | immunosuppression due to antineoplastic drugs or malignant tumor leaves patients extremely vulnerable to infection. opportunistic fungi that rarely infect healthy persons can have very severe consequences in these patients. candida albicans is the pathogen found most often, but several other candida species may cause infection as well. aspergillosis is the second most frequently seen fungal infection of the face and mouth in patients receiving chemotherapy. less commonly seen but equally dangero ... | 1992 | 1561171 |
| candidemia in immunocompromised patients. | this study reviews data on patients with fungemia and confirms the high prevalence (50%) of infections caused by non-albicans species of candida. fungemia due to c. albicans or torulopsis glabrata occurred significantly more often in patients with a solid tumor, while fungemia due to candida tropicalis or candida krusei was significantly more common in patients with hematologic malignancy (p = .001). for 31% of patients, only a single blood culture was positive for yeasts, and the prognosis for ... | 1992 | 1562683 |
| cloning system for candida glabrata using elements from the metallothionein-iia-encoding gene that confer autonomous replication. | the yeast candida glabrata harbors two distinct gene families that encode metallothioneins (mts). one of these loci, the mt-iia locus, exhibits selective and tandem amplification in many wild type strains of c. glabrata. the present paper demonstrates that the amplified mt-iia gene contains autonomously replicating sequences (ars). these ars elements have been used to construct vectors capable of replicating in c. glabrata. the ars element(s) in the mt-iia gene were localized to a 457-bp segment ... | 1992 | 1563627 |
| structural study of a cell wall mannan-protein complex of the pathogenic yeast candida glabrata ifo 0622 strain. | we conducted a structural analysis of the cell wall mannan-protein complex (mannan) isolated from a pathogenic yeast, candida glabrata ifo 0622 strain. the chemical structure of mannobiose released from this mannan by treatment with 10 mm hcl at 100 degrees c for 1 h was identified as manp beta 1-2man. the treatment of this mannan with 100 mm naoh at 25 degrees c for 18 h gave a mixture of alpha-1,2- and alpha-1,3-linked oligosaccharides, from tetraose to biose, and mannose. the acid- and alkali ... | 1992 | 1567221 |
| vulvovaginal candidiasis refractory to treatment with fluconazole. | we present the case of an infertile patient, whose first attempt at ivf had to be postponed for 18 months due to a vulvovaginal yeast infection refractory to treatment. the main causative organism was a candida glabrata strain resistant to all the imidazolic agents tested. the organism and the host's humoral status were studied in depth, looking for possible causes of the refractoriness to treatment. | 1992 | 1587371 |
| fungemia with torulopsis glabrata after endoscopic biliary stent replacement. | we report a patient with disseminated cholangiocarcinoma who developed systemic fungemia subsequent to endoscopic retrograde cholangiopancreatography (ercp) and stent replacement. despite intensive systemic antifungal therapy with iv amphotericin b, the patient developed multiple complications and eventually succumbed to her underlying disease. cultures of the removed stent and blood were positive for the same organism, torulopsis glabrata. in an immunocompromised host during ercp manipulation, ... | 1992 | 1615944 |
| torulopsis glabrata peritonitis in a chronic hemodialyzed patient. | | 1992 | 1630561 |
| surveillance of nosocomial fungal infections in a burn care unit. | a survey was conducted to trace the source of nosocomial fungal infections in the burn care unit of nehru hospital, chandigarh, india, by collection of samples from wounds of 25 severely burnt patients and their surroundings. the environmental sampling revealed predominant fungal contamination by dematiceous hyphomycetes, aspergilli, penicillium, fusarium and yeasts (candida albicans, candida tropicalis, candida krusei, candida parapsilosis), whereas the colonising or invading fungi from the pat ... | 1992 | 1644487 |
| [in vitro antifungal activity of itraconazole, a new triazole antifungal agent, against clinical isolates from patients with systemic mycoses]. | the in vitro antifungal activity of itraconazole (itz), a new oral triazole antifungal agent, against clinical isolates from patients with systemic mycoses were compared with those of existing systemic antifungals, viz. ketoconazole (kcz), miconazole or amphotericin b. the studies were performed with 65 isolates of pathogenic yeasts and 13 isolates of aspergillus spp. using the agar dilution method on casitone agar. itz showed the most potent antifungal activities against isolates of pathogenic ... | 1991 | 1652654 |
| in vitro comparison of cilofungin alone and in combination with other antifungal agents against clinical isolates of candida species. | cilofungin, a lipopeptide antifungal agent, was tested for in vitro activity alone and in combination with ketoconazole, itraconazole, flucytosine and amphotericin b against 102 clinical isolates of candida species. at 48 hours all isolates of candida albicans, candida tropicalis, candida paratropicalis and candida glabrata were inhibited by less than or equal to 5 meg/ml of cilofungin. in contrast, the mic90 for candida krusei was 10 mcg/ml and for candida parapsilosis greater than 40 mcg/ml. t ... | 1991 | 1655435 |
| safety and efficacy of itraconazole in prevention of fungal infections in neutropenic patients. | in a non-randomized study the efficacy of itraconazole in preventing fungal infections in neutropenic patients was investigated. forty-seven patients with acute leukemia or advanced lymphoblastic lymphoma were enrolled. ninety-two episodes of severe neutropenia after chemotherapy were observed. mean duration of neutropenia was 24 days. norfloxacin was administered as prophylaxis against gram-negative infections and itraconazole 200 mg b.i.d. as antifungal prophylaxis. surveillance cultures of th ... | 1991 | 1660108 |
| hospital outbreaks with yeasts. | five previous outbreaks of disseminated candidosis due to candida albicans are reviewed and a new outbreak on a neonatal unit in belfast presented. this involved four disseminated cases. the control and definition of outbreaks by morpho-, immunoblot- and dna-typing is discussed. an outbreak of torulopsis glabrata infection involving 23 patients is described. this was defined by dna fingerprinting with the enzyme xba. there were five deaths attributable either completely or in part to the yeast i ... | 1991 | 1679789 |
| a gene required for rnase p activity in candida (torulopsis) glabrata mitochondria codes for a 227-nucleotide rna with homology to bacterial rnase p rna. | we have mapped a gene in the mitochondrial dna of candida (torulopsis) glabrata and shown that it is required for 5' end maturation of mitochondrial trnas. it is located between the trnafmet and trnapro genes, the same trna genes that flank the mitochondrial rnase p rna gene in the yeast saccharomyces cerevisiae. the gene is extremely at rich and codes for au-rich rnas that display some sequence homology with the mitochondrial rnase p rna from s. cerevisiae, including two regions of striking seq ... | 1991 | 1705011 |
| reassessment of antigenic determinant of saccharomyces cerevisiae serotype ia. | we examined the immunochemical structure of the antigenic determinant of s. cerevisiae serotype ia. the specific factor serum for s. cerevisiae serotype ia was obtained either from factor 18 serum by adsorption with heat-killed cells of candida glabrata, or from anti-s. cerevisiae ia (m 6001) serum by adsorption with heat-killed cells of s. cerevisiae ib (ifo 0751). we designated this adsorbed serum as factor 18a. acetolysis of s. cerevisiae cell wall d-mannan gave five oligosaccharides. signals ... | 1990 | 1706464 |
| a cell surface/plasma membrane antigen of candida albicans. | antibody from balb/cbyj mice immunized against a membranous fraction of candida albicans agglutinated whole cells as well as the membranous fraction. hybridoma techniques were used to isolate an igm monoclonal antibody (mab) designated 10g which agglutinated whole cells and reacted with the subcellular fraction. yeast cells of 15 additional c. albicans strains and isolates of c. stellatoidea, c. tropicalis, c. intermedia and c. lusitaniae were also agglutinated by mab 10g. the antigen was not de ... | 1991 | 1709679 |
| hsp 90, yeasts and corynebacterium jeikeium. | recovery from disseminated candidosis is associated with seroconversion to a 47 kda breakdown product of the heat shock protein (hsp) 90 of candida albicans. cloning, sequencing and epitope mapping has allowed the delineation of the immunodominant epitopes lkvirknivkkmie and stdepagesa. monoclonal and polyclonal antibodies specific to these epitopes are used to show that all strains of c. albicans tested produce hsp 90 in both the yeast and mycelial phases. homologous proteins are demonstrated i ... | 1991 | 1718769 |
| synthesis, specificity, and antifungal activity of inhibitors of the candida albicans delta 24-sterol methyltransferase. | a series of side chain modified analogues of cholesterol and lanosterol (1-10) have been synthesized and evaluated as inhibitors of the candida albicans delta 24-sterol methyltransferase. two sterol substrate analogues 1 and 2 which contained a 24-thia substituent were relatively modest inhibitors of the enzyme (ki = 1.5-72 microm). compounds which mimic the carbocation intermediates proposed for the methyltransferase reaction, including sulfonium salts 4-6, amidines 7 and 8, and imidazoles 9 an ... | 1992 | 1732516 |
| electrophoretic karyotypes of clinically isolated yeasts of candida albicans and c. glabrata. | one-hundred-and-four isolates of yeast were collected from the vaginas of 97 outpatients. the isolates were identified by their characteristics in a carbohydrate assimilation test, a serological test and from their morphology. candida albicans and candida glabrata were the major isolates (75% and 20%, respectively). the karyotypes of the isolates were analysed by pulsed-field gel electrophoresis and almost all the karyotypes were distinguishable from one another when the band mobilities were car ... | 1991 | 1783899 |
| effect of culture media on in vitro susceptibility testing of fluconazole against some yeasts. | thirty clinical isolates, comprising six strains of candida albicans, and four strains each of c. lusitaniae, c. parapsilosis, c. tropicalis, cryptococcus neoformans, torulopsis glabrata and trichosporon beigelii were tested against fluconazole, using sabouraud's dextrose (sd) broth and a high resolution (hr) medium (pfizer central research, inc.). the procedure was a standard tube (1 ml/tube) dilution, and c. albicans y01 09 was included as a reference strain to monitor quality and reproducibil ... | 1991 | 1803235 |
| development of resistance in candida isolates from patients receiving prolonged antifungal therapy. | the impact of prolonged antifungal therapy on the development of resistance was examined in 61 patients with oropharyngeal thrush. fifty-nine patients had symptomatic human immunodeficiency virus infection, one had lung cancer, and one had metastatic prostate cancer. cultures of pharyngeal samples from all patients were positive for yeasts and included 57 (93.4%) candida albicans, 3 (4.9%) candida glabrata, and 1 (1.6%) candida krusii. of 61 patients, 32 (52.5%) were receiving or had recently re ... | 1991 | 1804002 |
| oral yeasts, mucosal health, and drug use in an elderly denture-wearing population. | drug use among the elderly may be a factor in oral mucosal pathology and the prevalence of oral yeasts. this study was designed to evaluate the relationship between oral yeast, denture-bearing mucosal health and drug use, especially drugs with known hyposalivatory side effects. there was an inverse relationship between denture-bearing mucosal health, and hyposalivatory drug use r = -0.41 p less than 0.04. use of drugs with a hyposalivatory side effect was related to increased numbers of candida ... | 1991 | 1813993 |
| [torulopsis glabrata. morphologic characteristics, biotyping and sensitivity to isolates of antifungal agents in vitro]. | the authors described morphological and biochemical properties of twenty strains of torulopsis glabrata and two strains of t. candida and t. sphaerica, mostly of human origin. by means of eight biotyping tests based on the evaluation of so-called resistograms the isolates of t. glabrata were divided into eight biotypes. the authors discussed the problem of possible use of biotyping of t. glabrata in investigations of the epidemiology and pathogenesis of mycoses caused by this microorganism. in i ... | 1991 | 1826472 |
| granulocyte-macrophage colony-stimulating factor augments neutrophil killing of torulopsis glabrata and stimulates neutrophil respiratory burst and degranulation. | the effects of granulocyte-macrophage colony-stimulating factor (gm-csf) on the interaction between the fungus torulopsis glabrata and human neutrophils was examined. pre-incubation of neutrophils with gm-csf increased the neutrophil fungal killing. the cytokine also increased the oxygen-dependent respiratory burst in response to opsonized fungi, measured by the lucigenin-dependent chemiluminescence assay and superoxide release. under the same conditions the cytokine augmented release of constit ... | 1991 | 1847097 |
| comparison study of broth macrodilution and microdilution antifungal susceptibility tests. | an evaluation of broth dilution antifungal susceptibility tests was performed by determining both the micro- and macrodilution mics of amphotericin b, flucytosine, fluconazole, ketoconazole, and cilofungin against 38 isolates of candida albicans, candida lusitaniae, candida parapsilosis, candida tropicalis, cryptococcus neoformans, and torulopsis glabrata. the following preliminary antifungal working group recommendations of the national committee for clinical laboratory standards for broth macr ... | 1991 | 1864923 |
| agar disk diffusion susceptibility tests with cilofungin (ly 121019). | cilofungin (ly 121019) is a semi-biosynthetic lipopeptide agent which is active both in vitro and in vivo against isolates of candida species. the purpose of this study was to demonstrate the usefulness of experimental 10- and 20-micrograms cilofungin disks in predicting probable in vitro susceptibility to this drug. fifty-two isolates of pathogenic yeasts, which included 34 isolates of candida albicans, 10 isolates of candida tropicalis and eight isolates of candida glabrata, were tested. both ... | 1991 | 1880684 |
| dramatic size variation of yeast mitochondrial rnas suggests that rnase p rnas can be quite small. | the gene coding for the au-rich rna required for mitochondrial rnase p activity in saccharomyces cerevisiae codes for a 490-base rna while that in candida glabrata codes for a 227-base rna. we have detected a 140-nucleotide rna coded by the mitochondrial dna from saccharomycopsis fibuligera by hybridization with an oligonucleotide complementary to a conserved sequence found in mitochondrial and prokaryotic rnase p rnas. dna sequence analysis of the mitochondrial dna from the region coding for th ... | 1991 | 1918032 |
| fatty acid analysis of different candida species by capillary column gas-liquid chromatography. | gas-liquid chromatography was used to analyse the fatty acid composition of whole-cell hydrolysates of 40 yeast strains representing 5 candida species and torulopsis glabrata, t. glabrata could be easily distinguished from all other candida spp. by the absence of c18:3. candida albicans, c. krusei, c. parapsilosis, c. pseudotropicalis and c. tropicalis showed 10 major peaks in characteristic proportions. c. parapsilosis showed a high c16:0/c16:1 ratio (greater than 4.5), whereas c. pseudotropica ... | 1991 | 1922189 |
| single dose treatment of vaginal candidosis: randomised comparison of amorolfine (50 mg and 100 mg) and clotrimazole (500 mg) in patients with vulvovaginal candidosis. | a double blind randomised comparative study of single dose treatment with amorolfine vaginal tablets (50 mg and 100 mg) and clotrimazole 500 mg monodose vaginal tablets (open labelled) was undertaken in patients with vaginal candidosis. vaginitis was demonstrated by both a positive culture and positive findings on microscopic examination of a vaginal smear as well as by the presence of clinical symptoms. 118 patients seen over a 6 month period were randomly allocated to receive one 50 mg vaginal ... | 1991 | 1922194 |
| rolling circle replication of dna in yeast mitochondria. | the conformation of mitochondrial dna (mtdna) from yeasts has been examined by pulsed field gel electrophoresis and electron microscopy. the majority of mtdna from candida (torulopsis) glabrata (mtdna unit size, 19 kb) exists as linear molecules ranging in size from 50 to 150 kb or 2-7 genome units. a small proportion of mtdna is present as supercoiled or relaxed circular molecules. additional components, detected by electron microscopy, are circular molecules with either single- or double-stran ... | 1991 | 1935911 |
| evaluation of the microscan rapid yeast identification panel. | the microscan rapid yeast identification (ryi) panel is a 4-h microdilution system for identification of clinical yeastlike isolates. its accuracy was evaluated by using 357 isolates encompassing 11 genera and 30 species. the ryi panel identifications were compared with those obtained by the api 20c system assisted with morphological characterization on cornmeal-tween 80 agar. the panels were read both visually and with the autoscan-4, a computer-controlled microplate reader. both the ryi panel ... | 1991 | 1939587 |
| candida albicans stimulates endothelial cell eicosanoid production. | the response of human umbilical vein endothelial cells to invasion by candida species was examined in vitro. live candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. since prostaglandin i2 (pgi2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. the ability of different strains and species of candida to induce endothelial pgi2 release was closely related to their capacity to injure the endothelium ... | 1991 | 1940471 |
| identification of oral yeasts by polyacrylamide gel electrophoresis. | protein profiles of sonicated cells for 9 species of yeast isolated from oral samples were obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page), and visualized with a silver stain. the profiles obtained on 12% acrylamide gels were distinct, and characteristic for 6 species of candida, and torulopsis glabrata, yarrowia lipolytica, and saccharomyces cerevisiae. using this method, 79 fresh isolates of yeasts from saliva samples were identified; 58 as candida albicans, 9 ... | 1991 | 1945503 |
| rnase p rna in candida glabrata mitochondria is transcribed with substrate trnas. | the biosynthesis of some mitochondrial enzymes requires contributions of both the mitochondrial and nuclear genomes. the ribonucleoprotein enzyme ribonuclease p (rnase p) is composed of a mitochondrial encoded rna and nuclear coded protein in many yeasts, including c. glabrata. we have determined that there are at least two sites of transcription initiation that contribute to the expression of the mitochondrial rnase p rna. a nonanucleotide promoter sequence is located upstream of the initiator ... | 1991 | 1956782 |
| [bilateral torulopsis glabrata pneumonia]. | in a 48-year old male patient hospitalized for evaluation of fatigue with non-productive cough and dyspnoea, standard radiography and computerized tomography of the chest showed nodular opacities in both lung apices. examination of intrabronchial specimens revealed mycelial filaments, and torulopsis glabrata grew in culture. under antifungal treatment the clinical signs rapidly improved and the radiological abnormalities disappeared more slowly, which confirmed the diagnosis of t. glabrata pneum ... | 1991 | 1957105 |
| endophthalmitis from contaminated donor corneas following penetrating keratoplasty. | we encountered six (0.2%) cases of endophthalmitis resulting from contaminated donor corneas between january 1983 and july 1990 following a total of 3000 consecutive penetrating keratoplasties. causative organisms in the three cases of fungal endophthalmitis were torulopsis glabrata, candida albicans, and aspergillus flavus; the three cases of bacterial endophthalmitis were due to klebsiella pneumoniae, staphylococcus aureus, and enterococcus faecalis. all organisms were resistant to gentamicin ... | 1991 | 1987949 |
| evolutionary relationships among pathogenic candida species and relatives. | small subunit rrna sequences have been determined for 10 of the most clinically important pathogenic species of the yeast genus candida (including torulopsis [candida] glabrata and yarrowia [candida] lipolytica) and for hansenula polymorpha. phylogenetic analyses of these sequences and those of saccharomyces cerevisiae, kluyveromyces marxianus var. lactis, and aspergillus fumigatus indicate that candida albicans, c. tropicalis, c. parapsilosis, and c. viswanathii form a subgroup within the genus ... | 1991 | 2007550 |
| effect of hydrogen peroxide on growth of candida, cryptococcus, and other yeasts in simulated blood culture bottles. | the addition of hydrogen peroxide to blood contained in liquid culture medium increased the dissolved-o2 partial pressure in direct proportion to the volume injected. the effect of hydrogen peroxide on the growth of subcultured clinical isolates of candida albicans, cryptococcus neoformans, torulopsis glabrata, and other yeasts and on the growth of blood culture isolates of representative pathogenic bacteria was compared with its effect on their growth in vented and unvented stationary bottles. ... | 1991 | 2007641 |
| in vitro susceptibility of 119 yeast isolates to fluconazole, 5-fluorocytosine, amphotericin b and ketoconazole. | the in vitro activity of fluconazole was tested against 13 yeast species (119 strains) isolated from clinical specimens during a 3-month period. for comparative purposes, three other antifungal compounds (5-fluorocytosine, amphotericin b and ketoconazole) were also tested. the tests were carried out using a microautomated method previously developed in our laboratory. the method allowed us to determine the minimum inhibitory concentration (mic) of the four antifungal drugs used. for each of the ... | 1991 | 2013239 |
| [reducing vaginal flora by preoperative disinfection]. | in 70 gynaecological patients vaginal disinfection by povidone-iodine and chlorhexidine solution (lec) was investigated. the preoperative bacterial spectrum corresponded to the specifications in literature. only lactobacilli were found in fewer cases than expected, an effect, which was explained by the povidone-iodine sanitation of the vagina a day before the operation. in cases of disturbed lactobacilli flora, facultative pathogen species were found in high concentrations up to 10(6) cfu/ml. ge ... | 1991 | 2026302 |
| clinical comparison of the recoveries of bloodstream pathogens in septi-chek brain heart infusion broth with saponin, septi-chek tryptic soy broth, and the isolator lysis-centrifugation system. | the recoveries of microorganisms in the septi-chek biphasic tryptic soy broth (tsb) and isolator blood culturing systems were compared with the recovery in septi-chek biphasic brain heart infusion broth supplemented with the lytic agent saponin (l-bhib; roche diagnostics, division of hoffmann-la roche inc.). a total of 5,096 tsb-l-bhib blood culture sets and 1,778 isolator-l-bhib sets were evaluated. there were 435 pathogenic organisms recovered in 413 (8.1%) of the tsb-l-bhib cultures, with 348 ... | 1991 | 2056056 |
| isolation of a metal-activated transcription factor gene from candida glabrata by complementation in saccharomyces cerevisiae. | metal-inducible transcription of metallothionein (mt) genes involves the interaction of metal-responsive trans-acting factors with specific promoter dna sequence elements. in this report, we present a genetic selection using the baker's yeast, saccharomyces cerevisiae, to clone a gene from candida glabrata encoding a metal-activated dna-binding protein denoted amt1. this selection is based on the ability of the amt1 gene product to activate expression of the c. glabrata mt-i gene in a copper-sen ... | 1991 | 2068090 |
| denture stomatitis in the elderly. | a study was carried out of 121 elderly edentulous individuals living in institutionalised homes in the lothian region, scotland to determine the prevalence of yeasts and associated oral disease. clinical examinations found that 65(54%) of the individuals suffered from denture stomatitis, and yeasts were recovered from 51(78%) of these individuals. the main yeasts isolated were torulopsis glabrata and candida albicans. culture of saliva samples produced a slightly higher recovery rate of yeasts c ... | 1990 | 2087353 |
| [in vitro sensitivity to 5-fluorocytosine and amphotericin b of yeasts of the candida genus isolated in barcelona]. | in 200 strains of candida sp, 38.5% were found to have intermediate sensitivity or to be resistant to amphotericin b and/or 5-fluorocytosine by the agar diffusion method. when the minimal inhibitory concentrations of these strains were measured, only 7.8% were resistant to amphotericin b and 2.8% to 5-fluorocytosine. the species with the highest levels of resistance were c. parapsilosis, c. tropicalis and torulopsis glabrata. candida albicans did not show resistance to 5-fluorocytosine. | 1990 | 2098147 |
| susceptibility of several species of candida and torulopsis to fluconazole and ketoconazole. | the authors compared the in vitro antifungal activity of fluconazole, a new triazole antifungal agent, and ketoconazole, an imidazole derivative. the mic values were determined against 50 strains of candida albicans, 10 strains of c. guilliermondii, 10 strains of c. krusei, 10 strains of c. parapsilosis, 10 strains of c. pseudotropicalis, 10 strains of c. tropicalis and 15 strains of torulopsis glabrata. the fungistatic activity was evaluated by the agar dilution method using bhi and casitone me ... | 1990 | 2100733 |
| killing of coccidioides immitis by hypochlorous acid or monochloramine. | to identify possible explanations for the resistance of coccidioides immitis to killing by human neutrophils, its susceptibility to typical oxidants generated during the neutrophil respiratory burst was compared to the sensitivity of other microbes. when microbial suspensions were exposed to hypochlorous acid, arthroconidia or spherules of c. immitis were killed more slowly than yeast cells of candida (torulopsis) glabrata or staphylococcus aureus. in contrast, exposure to the more lipophilic ox ... | 1990 | 2166156 |
| [comparative sensitivity of yeasts to ketoconazole, itraconazole and fluconazole using a liquid medium standardized micromethod]. | the minimal inhibitory concentrations of 200 yeast strains (48 reference strains and 152 recently isolated from pathological products) were evaluated with a new standardized micromethod using a liquid medium comparatively for ketoconazole, itraconazole and fluconazole. the ready-to-use microtitration plates contained the antifungal agents in concentrations ranging from 100 to 0.10 mg/l. the cumulative mic curves clearly showed the superiority of ketoconazole, fluconazole being the less active pr ... | 1990 | 2166937 |
| characterization of the sequence of colonization and nosocomial candidemia using dna fingerprinting and a dna probe. | the objective of this hospital-based study was to determine the relationship between colonizing and infecting strains of candida species and torulopsis glabrata. surveillance cultures from high-risk patients were paired with subsequent bloodstream isolates. organisms were typed by using restriction endonuclease digestion of chromosomal dna with bstni and ecori, followed by southern hybridization with a dna probe (pbd4) derived from saccharomyces cerevisiae. sixteen patients for whom documented c ... | 1990 | 2177750 |
| the role of yeasts in oral cancer by means of endogenous nitrosation. | oral leukoplakias, particularly non-homogeneous types, are often invaded by yeasts, with candida albicans being the dominant species. the more advanced precancerous leukoplakia lesions yield more rarely occurring biotypes of c. albicans, suggesting a causal role for these biotypes in the malignant transformation. n-nitroso-benzylmethylamine (nbma) is a compound able to induce carcinoma of the esophagus and the oral cavity in the rat. the catalytic potential of yeasts, isolated from leukoplakia l ... | 1990 | 2181815 |
| an anti-cryptococcus neoformans monoclonal antibody directed against galactoxylomannan. | six monoclonal antibodies (mab) were produced by immunizing mice with a cryptococcus neoformans serotype a spheroplast lysate (cnsl). two mab were of the igg1 isotype; the others were igm. the results obtained with one igm mab (cn6) are reported herein. this mab recognized the four serotypes of c. neoformans and no cross-reactions were observed with extracts from cryptococcus melibiosum, candida albicans, saccharomyces cerevisiae, torulopsis glabrata or trichosporon beigelii. fractionation of th ... | 1990 | 2189167 |
| growth of opportunistic yeasts on vitamin-free solid medium. | the growth of some opportunistic yeasts (candida albicans, cryptococcus neoformans, torulopsis glabrata, rhodotorula rubra, geotrichum candidum, trichosporon cutaneum, saccharomyces cerevisiae) was essayed in a solid minimal synthetic medium without vitamins. from the preliminary results some species (candida albicans, cryptococcus neoformans, rhodotorula rubra, geotrichum candidum and saccharomyces cerevisiae) seem to be autotrophic regarding the growth factor considered indispensable for their ... | 1990 | 2191196 |
| characterization of the mycoflora from oral mucosal surfaces of some hiv-infected patients. | oral mucosal surfaces from 54 patients seropositive for human immunodeficiency virus (hiv) were assayed for the presence of cultivable yeasts. oral colonization with candida albicans, represented by 6 biotypes, was evident in 35 persons. the closely related variant, candida stellatoidea, was found in 3 patients. single isolates of candida parapsilosis, candida glabrata, candida tropicalis, and candida paratropicalis were also identified. one patient harbored a population of saccharomyces cerevis ... | 1990 | 2192330 |
| systemic torulopsis glabrata infection in a neonate. | we have reported a case of neonatal torulopsis glabrata peritonitis and ventriculitis associated with a ventriculoperitoneal shunt. treatment of fungemia and ventriculitis with amphotericin b and 5-fluorocytosine was successful. | 1990 | 2196697 |
| discriminant analysis of cellular fatty acids of candida species, torulopsis glabrata, and cryptococcus neoformans determined by gas-liquid chromatography. | we used discriminant analysis of cellular fatty acid compositions determined by gas-liquid chromatography to differentiate yeastlike fungi (a total of 190 strains; including 37 candida albicans strains, 21 candida krusei strains, 13 candida guilliermondii strains, 37 candida tropicalis strains, 10 candida pseudotropicalis strains, 24 candida parapsilosis strains, 32 torulopsis glabrata strains, and 16 cryptococcus neoformans strains). previous results with a standard strain of c. albicans indica ... | 1990 | 2199515 |
| multivariate analyses of cellular carbohydrates and fatty acids of candida albicans, torulopsis glabrata, and saccharomyces cerevisiae. | quantitative data of major cellular carbohydrates distinguished candida albicans or torulopsis glabrata from saccharomyces cerevisiae but not c. albicans from t. glabrata. multivariate analyses of both carbohydrate and fatty acid variables (i. brondz, i. olsen, and m. sjöström, j. clin. microbiol. 27:2815-2819, 1989), however, differentiated all three species. | 1990 | 2203815 |
| osteomyelitis of the hyoid caused by torulopsis glabrata in a patient with acquired immunodeficiency syndrome. | | 1990 | 2213316 |
| torulopsis glabrata vaginitis: clinical aspects and susceptibility to antifungal agents. | torulopsis glabrata is second only to candida albicans in frequency of isolation from the vagina in both asymptomatic women and patients with yeast vaginitis. we retrospectively studied 33 patients from whom vaginal isolates of t glabrata were obtained. torulopsis glabrata caused symptomatic vaginitis in 42% of the patients but was unassociated with symptoms in 30%; in 27% of patients, its importance was uncertain because of concomitant pathology. antifungal susceptibility testing was performed ... | 1990 | 2216197 |
| effects of incubation temperature, inoculum size, and medium on agreement of macro- and microdilution broth susceptibility test results for yeasts. | we examined the effects of temperature and inoculum on the agreement of macro- and microdilution broth mics of five antifungal agents against six isolates of candida species or torulopsis glabrata. incubation temperature affected results with amphotericin b, flucytosine, fluconazole, and sch 39304, producing better agreement at 35 degrees c than at 37 degrees c. agreement between methods was better with an inoculum size of 10(2) than with one of 10(4) yeast cells per ml in testing fluconazole or ... | 1990 | 2221863 |
| [identification and susceptibility of clinically isolated yeast-like fungi]. | we studied the identification and susceptibility of clinically isolated yeast-like fungi at showa university hospital from april 1988 to march 1989. clinically significant of yeast-like fungi were observed in 7.1% of specimens from outpatients, 13.0% of inpatients. in both outpatients and inpatients, yeast-like fungi were isolated mainly from sputum and urine. but, one third of them were considered as non-pathogenic and not identified. the species of isolates were, candida albicans 57%, candida ... | 1990 | 2232256 |
| [in vitro antifungal activity of mercurobutol]. | mercurobutol, in its commercial form, exhibits fungistatic and fungicidal activities against both yeasts: candida albicans, c. tropicalis, torulopsis glabrata, pityrosporum spp., and filamentous fungi: dermatophytes, aspergillus fumigatus, mainly saprophytic or potentially pathogenic fungi of the cutaneo-mucous flora. minimal inhibitory concentrations on this antiseptic indicate a high susceptibility of the species tested, that could justify the enlargement of the indication of the drug to the c ... | 1990 | 2235087 |
| enhanced detection of candida in blood cultures with the bactec 460 system by use of the aerobic-hypertonic (8b) medium. | the blood culture records during the 6-year period 1984-9 were reviewed to compare the performance of the bactec aerobic (6b) and aerobic-hypertonic (8b) media for the recovery of candida spp. and torulopsis glabrata from blood. there were 137 positive blood culture sets that contained both a 6b and an 8b bottle. sixty-eight different yeasts were recovered from 65 patients including 35 candida albicans, 19 c. tropicalis, 6 c. parapsilosis, 4 c. krusei, 1 c. pseudotropicalis and 3 torulopsis glab ... | 1990 | 2249719 |
| uptake of pyrimidines and their derivatives into candida glabrata and candida albicans. | the uptake of pyrimidines and their derivatives into candida glabrata and candida albicans was measured using a novel technique in which the cells were rapidly separated from their suspending medium by centrifugation through a layer of an inert oil. the uptake of [14c]cytosine was linear for 30 s for all concentrations of pyrimidine tested. in c. glabrata but not c. albicans cytosine transport was mediated by both a high affinity (km 0.8 +/- 0.1 microm), low capacity [v 40 +/- 4 pmol (microliter ... | 1990 | 2262788 |
| reactivity of cryptococcus neoformans & candida species with concanavalin a & blood grouping sera. | forty strains of cryptococcus neoformans, 30 of candida albicans, 24 of c. parapsilosis and 10 strains each of c. tropicalis and c. (torulopsis) glabrata were examined. a 0.2 per cent solution of concanavalin a (con a) in phosphate buffered saline and commercial anti-a and anti-b blood grouping sera were used in the whole cell slide agglutination test. all the isolates of candida species strongly reacted with con a and over 90 per cent were agglutinated by anti-a and -b blood grouping sera. in c ... | 1990 | 2269512 |
| 19f nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of candida glabrata with specific defects in pyrimidine metabolism. | flucytosine (5-fc)-resistant strains were isolated from the haploid opportunistic pathogen candida glabrata by uv-induced mutation and fluoropyrimidine selection. these strains were characterized biochemically, and the metabolism of fluorinated pyrimidines was studied by 19f nuclear magnetic resonance spectroscopy. no evidence was obtained from these studies for degradative metabolism of the fluorinated derivatives. in the parental susceptible strain of c. glabrata, 5-fluorouracil but not 5-fc w ... | 1990 | 2291666 |
| in vitro susceptibility testing of candida isolates from clinical specimens to four antifungal agents. | a total of 231 isolates of candida species including 163 of candida albicans (132 of serotype a and 31 of serotype b), 42 of candida tropicalis, 17 of candida glabrata, 7 of candida parapsilosis and 2 of candida krusei were collected from clinical specimens in two medical centers, one in japan and the other in the united states. the in vitro antifungal activities of amphotericin b, 5-fluorocytosine, miconazole and fluconazole were evaluated for the above isolates by means of a photo-read broth m ... | 1990 | 2292203 |
| torulopsis glabrata fungemia in a diabetic patient. | we have presented a case of a stable diabetic outpatient who had an acute illness that proved to be torulopsis glabrata fungemia responsive to amphotericin b therapy. her only apparent additional predisposition was a nonobstructing renal calculus. fungemia with this organism in an outpatient is most unusual. t glabrata should be an additional consideration in outpatient as well as inpatient illnesses, especially in diabetic women. | 1990 | 2315789 |
| selective and tandem amplification of a member of the metallothionein gene family in candida glabrata. | metallothioneins constitute a multigene family in the yeast candida glabrata. two genes, designated metallothionein-i (mt-i) and one member of the metallothionein-ii family (mt-ii), were cloned and sequenced previously (mehra, r. k., garey, j. r., butt, t. r., gray, w. r., and winge, d. r. (1989) j. biol. chem. 264, 19747-19753). southern analysis of the genomic dna samples from different wild-type isolates indicated that the mt-i gene was always present as a single copy but multiple (3-9) and t ... | 1990 | 2318858 |
| sequence of the gene for the cytoplasmic ribosomal rna small subunit from candida (torulopsis) glabrata. | | 1990 | 2336362 |
| d-lactic acidosis in short bowel syndrome--an examination of possible mechanisms. | two patients, both with short bowel syndrome, presented with severe d-lactic acidosis associated with subacute small bowel obstruction and bizarre neurological signs. in neither patient were d-lactic acid-producing organisms isolated from the upper intestine. in both, upper intestinal aspirates yielded a glucose-fermenting yeast, torulopsis glabrata. although intestinal aspirates from both contained significant quantities of ethanol alcohol could not be detected in concomitant blood samples. a g ... | 1990 | 2345785 |
| fungal diarrhoea: association of different fungi and seasonal variation in their incidence. | a total of 854 patients (640 children and 214 adults) admitted with acute or chronic diarrhoea suspected of non-invasive overgrowth of fungi in intestine were screened during a period of 3 years. fungal proliferation was noted in 54.8% of these patients (53.6% in children, 58.4% in adults). the predominant fungal species isolated were candida albicans (64.5%), followed by c. tropicalis (23.3%) c. krusei (6.9%). torulopsis glabrata (1.6%). trichosporon sp. and geotrichum sp. were found to be resp ... | 1990 | 2366849 |
| the antigenic relationship between candida (torulopsis) glabrata and escherichia coli (0:75, 0:163), salmonella aberdeen o antigens. | | 1988 | 2463848 |
| [adherence of candida albicans to acrylic surfaces]. | the ability of candida albicans ifo 1385 to adhere to acrylic and the partial characterization of an adhesive substance, named as, which was isolated from the yeast, were studied in vitro. the results obtained were as follows: 1. the cells cultured in the synthetic media (ynb) containing 500 mm galactose showed a much greater tendency to adhere than did those cells cultured in the ynb containing 500 mm glucose. 2. more cells prepared by the standing cultivation adhered to acrylic than did those ... | 1989 | 2486701 |
| [in vitro activity of fluconazole, a novel bistriazole antifungal agent]. | fluconazole is a novel triazole antifungal agent with excellent activities against a broad range of medically important fungi. the in vitro antifungal activities of fluconazole especially against candida albicans were examined and the results summarized as follows: 1. fluconazole was proved to exhibit the highest antifungal activity in synthetic amino-acid medium, fungal (saamf), well buffered in a physiologically neutral range. 2. in a exposed time-killing test performed using saamf (ph 7.4), t ... | 1989 | 2540356 |
| secondary mycosis in surgery: treatment with fluconazole. | together with the severity of the underlying disease, mycotic infections are assuming increasing significance in surgical patients under intensive care. 26 patients with severe internal mycotic infections were treated with fluconazole in an open clinical trial. the pathogens isolated were candida albicans in 22 cases, candida tropicalis in four, torulopsis glabrata in three, candida parapsilosis in two and aspergillus fumigatus in one. mixed infections were found in five cases. most of this seri ... | 1989 | 2541084 |
| itraconazole vs amphotericin b: in vitro comparative evaluation of the minimal inhibitory concentration (mic) against clinically isolated yeasts. | itraconazole is a triazole compound which, following several clinical trials, has begun to be used for therapy of mycotic infections. this new drug, with a broad-spectrum antifungal activity, can be orally administered. the authors studied the in vitro susceptibility to amphotericin b and itraconazole of the following clinical isolates of pathogenic yeasts: 100 candida albicans, 20 c. tropicalis, 20 c. parapsilosis, 8 c. guilliermondii, 6 c. pseudotropicalis, 24 torulopsis glabrata and 16 crypto ... | 1989 | 2549421 |
| fluconazole treatment of candida glabrata peritonitis. | | 1989 | 2550416 |
| comparison of in vivo activity of fluconazole with that of amphotericin b against candida tropicalis, candida glabrata, and candida krusei. | fluconazole (uk-49,858) is a new oral bis-triazole antifungal agent with demonstrated activity against candida albicans. because of the increasing importance of infections due to other species of candida, we studied the efficacy of fluconazole in a rat model of established systemic candidiasis, using clinical isolates of c. tropicalis, c. glabrata, and c. krusei. in normal rats, oral fluconazole at both 20 and 80 mg/kg per day for 7 days reduced both kidney and liver titers of c. tropicalis and ... | 1989 | 2554797 |
| in-vitro effects of cilofungin (ly121019), amphotericin b and amphotericin b-deoxycholate on human polymorphonuclear leucocytes. | the in-vitro influence of cilofungin (ly121019) and amphotericin b on human polymorphonuclear leucocytes (pmns) was studied by a multifunctional approach. cilofungin at high concentration (greater than or equal to 20 mg/l) increased adherence to plastic and ingestion of staphylococcus aureus by pmns in suspension and candida albicans by adherent pmns, and slightly decreased mtt reduction and superoxide generation. amphotericin b and amphotericin b-deoxycholate decreased adherence to plastic (ic5 ... | 1989 | 2557318 |
| candida glabrata metallothioneins. cloning and sequence of the genes and characterization of proteins. | southern blot analysis has identified several metallothionein gene sequences in a human pathogenic yeast candida glabrata. two of these genes encoding proteins designated mt-i and mt-ii have been cloned and sequenced. no introns were found in either of the genes. the complete primary structure of mt-ii was also determined by protein sequencing methods. as isolated, mt-i and mt-ii consist of 62 and 51 amino acids, respectively. the only residues predicted from the nucleotide sequence but not pres ... | 1989 | 2584191 |
| electrophoretic karyotypes of torulopsis glabrata. | chromosome-sized dna molecules of clinical isolates of torulopsis glabrata were resolved by a pulsed-field electrophoretic method, contour-clamped homogeneous electric fields. with the conditions established in this study, 8 to 12 bands (ranging from 445 to 3,000 kilobases) were observed. there were differences in the intensities and migrations of bands, consistent with t. glabrata being either haploid or diploid. a total of 22 distinctive electrophoretic patterns were noted among single isolate ... | 1989 | 2584368 |
| standardization of yeast inocula with an electronic impedance counter. | the standardization of yeast inocula has been identified as an important variable in the performance of reproducible in vitro fungal susceptibility testing. we investigated the precision and accuracy of an electronic particle counter in preparing yeast inocula, with quantitative culture used as a "gold standard." suspensions of candida albicans and torulopsis glabrata standardized with a particle counter at 10(6) counts per ml were highly reproducible when cultured quantitatively (coefficients o ... | 1989 | 2584389 |
| tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against torulopsis glabrata and candida albicans and associated increases in oxygen radical production and lysosomal enzyme release. | the capacity of human tumor necrosis factor alpha (tnf-alpha) to modulate the killing of the opportunistic pathogens torulopsis glabrata and candida albicans by human neutrophils was studied. tnf-alpha significantly enhanced neutrophil fungicidal activity in a concentration-dependent manner and was evident in a range of neutrophil-fungus ratios. enhanced killing of t. glabrata required much lower tnf-alpha concentrations than were required for enhancement of killing of c. albicans. maximal enhan ... | 1989 | 2659536 |
| in-vitro activity of cilofungin (ly121019) in comparison with amphotericin b. | the in-vitro activity of cilofungin, a derivative of echinocandin b, was compared with that of amphotericin b in sabouraud dextrose and antibiotic medium no. 3 against 100 clinical isolates of yeasts. cilofungin appeared to be as effective, as amphotericin b against candida albicans and yet more effective against can. tropicalis as far as growth inhibition was concerned. cilofungin was less active than amphotericin b against can. (torulopsis) glabrata and other species of candida. it was not act ... | 1989 | 2681118 |
| immunologic significance of diverse specificity of monoclonal antibodies against mannans of candida albicans. | two agglutinating igm mab against mannan ag of candida albicans strains were investigated for their specificity. the agglutinating patterns of both mab with a panel of stationary phase of yeast cells of standard strains did not match those of any known polyclonal antibody (pab) factors. the reactive patterns of both mab for a given panel of 202 isolates of seven candida species and the mode of competitive binding between mab and a pab factor, as determined by a combination of direct and indirect ... | 1989 | 2681415 |
| [deep candida and related yeast infections]. | yeast-like fungi that are commonly found on the skin and in the digestive tract of healthy people may be responsible for deep infections as well as for cutaneous and mucosal diseases. such deep infections have long been known in the case of candida spp.; they are facilitated by immunosuppression or by factors that enable this opportunistic organism to proliferate in the gut, skin or mucosae and to penetrate into deep tissues. in addition to such well-known clinical manifestations as septicaemia ... | 1989 | 2682988 |
| gas chromatographic assessment of alcoholyzed fatty acids from yeasts: a new chemotaxonomic method. | an alternative chemotaxonomic method to methanolysis was developed for gas chromatographic assessment of fatty acids in whole yeast cells. clinical and reference strains of the medically important yeasts candida albicans, torulopsis glabrata, and saccharomyces cerevisiae were cultured for 48 h at 26 degrees c. cellular lysis and transesterification were then performed with ethanol, propanol, butanol, or methanol. the relative recovery rates for cellular fatty acids, including the volatile acids ... | 1989 | 2687322 |
| in vitro antifungal activity of saperconazole (r 66905) against candida and torulopsis. | the susceptibility of several strains of candida and torulopsis to saperconazole, a new triazole antifungal compound, was compared to that of ketoconazole. the mics of the two antifungal agents were determined against 70 strains of candida albicans, 10 strains of c. guilliermondii, 10 strains of c. krusei, 10 strains of c. parapsilosis, 10 strains of c. pseudotropicalis, 10 strains of c. tropicalis and 15 strains of torulopsis glabrata. the fungistatic activity was evaluated by the agar dilution ... | 1989 | 2695841 |
| change of causative organisms under antifungal treatment in immunosuppressed patients with hiv-infections. | oral and esophageal candidosis are very common in hiv-infected patients. due to the lack of efficacy of topical antimycotics in advanced stages of hiv-infection oral azoles are mainly used for treatment. azoles most often used are ketoconazole and fluconazole. while candida albicans clearly is the most frequently encountered yeast before and after treatment other species can be found somewhat less frequently after treatment. this especially applies to candida glabrata. candida spp. other than c. ... | 1989 | 2700222 |
| [diagnostic and clinical characteristics of mycotic vaginitis caused by candida glabrata (torulopsis glabrata)]. | in this study an evaluation of frequency of occurrence of c. glabrata, its diagnosis, sensitivity to antifungal drugs and its significance in pathogenesis of mycotic vaginosis was performed. strains belonging to c. glabrata genus constituted 12.1% of total of 852 isolated strains and 39.2% of strains other than c. albicans. during fungal vaginosis caused by c. glabrata lactobacillus sp. was present and normal ph values of vaginal secretion were seen. in direct preparations single or few leukocyt ... | 1989 | 2701236 |
| incidence of yeasts in pregnant and non-pregnant women in nigeria. | the yeast flora of vagina and associated sites (cervix, urethra, perineum and rectum) in 224 pregnant and 106 non-pregnant nigerian women was investigated. a variety of yeasts represented by 12 species were isolated. candida albicans was the most frequently isolated species in both groups, accounting for 63.6% of the isolates from pregnant women and 44.8% of the isolates from non-pregnant women. other species of yeasts infrequently or occasionally encountered were torulopsis glabrata, c. tropica ... | 1989 | 2733724 |
| [effectiveness of selected disinfectant and antiseptic preparations on potentially pathogenic micromycetes]. | using the contact test, the author investigated the antifungal efficiency of 13 disinfectants and antiseptic preparations (hydrogen peroxide, persteril, jodonal b, jodisol, chlordetal, famosept-super, septonex, ajatin, cresolum saponatum, ethanol, desident spray, chlorhexidine, galli-valerio solution) against 23 strains of eight genera of microscopic fungi (absidia, aspergillus, candida, geotrichum, mucor, rhizopus, torulopsis and trichosporon). the results revealed that filamentous fungi and am ... | 1989 | 2736636 |
| fungemia caused by candida species and torulopsis glabrata in the hospitalized patient: frequency, characteristics, and evaluation of factors influencing outcome. | we reviewed 135 cases of candidemia occurring between 1983 and 1986 to examine oncologic and nononcologic populations and assess factors for survival. candida albicans was the most common species (51%); candida tropicalis occurred most frequently in leukemia patients (57%), whereas candida parapsilosis and torulopsis glabrata were associated with solid tumors and nononcologic diseases. risk factors identified were: preceding surgery, antibiotics, cannulas, and steroids in solid tumor and nononco ... | 1989 | 2749102 |
| [laboratory diagnostic possibilities in fungus infections in intensive care patients]. | severe yeast infections of intensive care patients are promoted by numerous predisposing factors among which antibacterial broad spectrum therapy plays an important role. since typical clinical pictures are lacking, basic procedures of mycological diagnostics are culture and differentiation of yeast strains and detection of immunological reactions against yeast antigens as well. among 200 intensive-care patients with suspected systemic mycosis, candida albicans was the prevailing yeast, followed ... | 1989 | 2764266 |
| in vitro sensitivity of candida (torulopsis) glabrata to clotrimazole. | vulvovaginitis caused by candida (torulopsis) glabrata is often refractory to intravaginal imidazole therapy. clotrimazole achieves its fungistatic activity for candida albicans and c. glabrata by inhibiting different steps in intermediary cell metabolism. for c. glabrata, alkylation precedes dimethylation. the possibility that this altered sequence might account for the relative therapeutic nonresponsiveness was studied by determining comparative minimal inhibitory concentrations (mics) of clot ... | 1989 | 2765132 |
| vibratory urticaria associated with bladder-wall infection with the yeast torulopsis glabrata. | | 1989 | 2778247 |
| susceptibility of candida species to cilofungin (ly-121019). | the antifungal activity of a new semi-synthetic lipopeptide named cilofungin (ly-121019) was studied in vitro on 102 strains of candida and torulopsis glabrata. a standardized protocol for susceptibility testing by means of a microtiter sabouraud broth dilution was used. the minimal inhibitory concentrations of cilofungin for c. albicans (n = 50) ranged from 0.039 to 5.0 micrograms/ml with a geometric mean of 0.47 micrograms/ml. the same results were obtained with c. tropicalis but one strain sh ... | 1989 | 2779613 |
| glutathione-coated cadmium-sulfide crystallites in candida glabrata. | cadmium-sulfide crystallites form in the yeast candida glabrata cultured in the presence of cadmium salts. the particles function to sequester and detoxify intracellular cadmium ions. the crystallites are peptide-coated, but the coating peptide varies with the nutrient conditions of the growth medium. when cultured in rich nutrient broth the yeast forms intracellular cds particles coated with a mixture of glutathione and the gamma-glutamylcysteine dipeptide. in contrast, cultures in synthetic mi ... | 1989 | 2793859 |
| fungal peritonitis in children on continuous ambulatory peritoneal dialysis. | between 1979 and 1985, six of 26 patients undergoing continuous ambulatory peritoneal dialysis developed fungal peritonitis. all had received antibacterial therapy with cefamandole and/or netilmicin prior to the diagnosis. the causal organisms were candida albicans (three), candida glabrata (one), cryptococcus laurentii (one) and saccharomyces cerevisiae (one). treatment comprised catheter removal preceded by antifungal drugs (flucytosine and/or amphotericin b) in four patients and catheter remo ... | 1989 | 2799371 |
| [torulopsis glabrata septicemia: apropos of a case]. | a 74 year's old patient with cancer of oesophagus has been operated. an atelectasis occurred just after surgery, then a septic shock with a septicaemia. blood cultures were positive with torulopsis glabrata. amphotericin b and flucytosine, followed by flucytosine and miconazole cured septicaemia. these septicaemia happen often to diabetics patients, to patients with malignant tumours, or after wide spectrum antibiotics or during prolonged parenteral nutrition or after surgery. | 1989 | 2802052 |
| evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens. | cilofungin (ly121019) is a new lipopeptide antifungal drug. we tested this drug against 141 pathogenic fungal isolates. all fungal species were tested by broth dilution at 35 degrees c. malassezia furfur was tested by agar dilution. the results demonstrate the specificity of cilofungin activity. candida albicans, candida tropicalis, and malassezia pachydermatis were highly susceptible, whereas candida parapsilosis, candida pseudotropicalis, candida krusei, torulopsis glabrata, blastomyces dermat ... | 1989 | 2802565 |
| ketoconazole resistance in torulopsis glabrata. | the majority of clinical isolates of t. glabrata has been shown highly sensitive to ketoconazole, when tested with an agar dilution method, and resistant, when using a broth dilution method. the fact was accounted for the high degree of mutation associated with the haploid state present in this species. experimental t. glabrata infection in immunocompetent and immunocompromised mice appears not respond to the oral administration of the drug. the results agree with that of broth dilution tests an ... | 1989 | 2811982 |