| agar disk diffusion susceptibility tests with cilofungin (ly 121019). | cilofungin (ly 121019) is a semi-biosynthetic lipopeptide agent which is active both in vitro and in vivo against isolates of candida species. the purpose of this study was to demonstrate the usefulness of experimental 10- and 20-micrograms cilofungin disks in predicting probable in vitro susceptibility to this drug. fifty-two isolates of pathogenic yeasts, which included 34 isolates of candida albicans, 10 isolates of candida tropicalis and eight isolates of candida glabrata, were tested. both ... | 1991 | 1880684 |
| [renal infection caused by torulopsis glabrata]. | | 1979 | 575267 |
| fatty acid analysis of different candida species by capillary column gas-liquid chromatography. | gas-liquid chromatography was used to analyse the fatty acid composition of whole-cell hydrolysates of 40 yeast strains representing 5 candida species and torulopsis glabrata, t. glabrata could be easily distinguished from all other candida spp. by the absence of c18:3. candida albicans, c. krusei, c. parapsilosis, c. pseudotropicalis and c. tropicalis showed 10 major peaks in characteristic proportions. c. parapsilosis showed a high c16:0/c16:1 ratio (greater than 4.5), whereas c. pseudotropica ... | 1991 | 1922189 |
| single dose treatment of vaginal candidosis: randomised comparison of amorolfine (50 mg and 100 mg) and clotrimazole (500 mg) in patients with vulvovaginal candidosis. | a double blind randomised comparative study of single dose treatment with amorolfine vaginal tablets (50 mg and 100 mg) and clotrimazole 500 mg monodose vaginal tablets (open labelled) was undertaken in patients with vaginal candidosis. vaginitis was demonstrated by both a positive culture and positive findings on microscopic examination of a vaginal smear as well as by the presence of clinical symptoms. 118 patients seen over a 6 month period were randomly allocated to receive one 50 mg vaginal ... | 1991 | 1922194 |
| esophagitis caused by torulopsis glabrata. case report. | | 1979 | 572135 |
| activation of the alternative complement pathway by torulopsis glabrata. | torulopsis glabrata is a yeast-like fungus with increasing importance as an opportunistic human pathogen. the role of serum complement in resistance to this infection was studied by chemotactic and opsonic assays. the results indicate that t. glabrata activates complement via the alternative pathway. this may be an important mechanism in host immunity to this fungus. | 1979 | 570297 |
| candida albicans stimulates endothelial cell eicosanoid production. | the response of human umbilical vein endothelial cells to invasion by candida species was examined in vitro. live candida albicans caused significant endothelial release of eicosanoids, mainly prostaglandins. since prostaglandin i2 (pgi2) is an important prostaglandin produced by endothelial cells, factors influencing its release were studied. the ability of different strains and species of candida to induce endothelial pgi2 release was closely related to their capacity to injure the endothelium ... | 1991 | 1940471 |
| identification of oral yeasts by polyacrylamide gel electrophoresis. | protein profiles of sonicated cells for 9 species of yeast isolated from oral samples were obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page), and visualized with a silver stain. the profiles obtained on 12% acrylamide gels were distinct, and characteristic for 6 species of candida, and torulopsis glabrata, yarrowia lipolytica, and saccharomyces cerevisiae. using this method, 79 fresh isolates of yeasts from saliva samples were identified; 58 as candida albicans, 9 ... | 1991 | 1945503 |
| ulcerative vaginitis due to torulopsis glabrata: a case report. | a patient with ulcerative vaginitis is presented. the differential diagnosis included malignant ulcer, chancroid, and granuloma venereum. torulopsis glabrata vaginitis, which was subsequently proven, responded successfully to clotrimazole suppositories. predisposing and related factors and isolation and identification procedures are discussed. | 1978 | 569709 |
| [bilateral torulopsis glabrata pneumonia]. | in a 48-year old male patient hospitalized for evaluation of fatigue with non-productive cough and dyspnoea, standard radiography and computerized tomography of the chest showed nodular opacities in both lung apices. examination of intrabronchial specimens revealed mycelial filaments, and torulopsis glabrata grew in culture. under antifungal treatment the clinical signs rapidly improved and the radiological abnormalities disappeared more slowly, which confirmed the diagnosis of t. glabrata pneum ... | 1991 | 1957105 |
| endophthalmitis from contaminated donor corneas following penetrating keratoplasty. | we encountered six (0.2%) cases of endophthalmitis resulting from contaminated donor corneas between january 1983 and july 1990 following a total of 3000 consecutive penetrating keratoplasties. causative organisms in the three cases of fungal endophthalmitis were torulopsis glabrata, candida albicans, and aspergillus flavus; the three cases of bacterial endophthalmitis were due to klebsiella pneumoniae, staphylococcus aureus, and enterococcus faecalis. all organisms were resistant to gentamicin ... | 1991 | 1987949 |
| evolutionary relationships among pathogenic candida species and relatives. | small subunit rrna sequences have been determined for 10 of the most clinically important pathogenic species of the yeast genus candida (including torulopsis [candida] glabrata and yarrowia [candida] lipolytica) and for hansenula polymorpha. phylogenetic analyses of these sequences and those of saccharomyces cerevisiae, kluyveromyces marxianus var. lactis, and aspergillus fumigatus indicate that candida albicans, c. tropicalis, c. parapsilosis, and c. viswanathii form a subgroup within the genus ... | 1991 | 2007550 |
| effect of hydrogen peroxide on growth of candida, cryptococcus, and other yeasts in simulated blood culture bottles. | the addition of hydrogen peroxide to blood contained in liquid culture medium increased the dissolved-o2 partial pressure in direct proportion to the volume injected. the effect of hydrogen peroxide on the growth of subcultured clinical isolates of candida albicans, cryptococcus neoformans, torulopsis glabrata, and other yeasts and on the growth of blood culture isolates of representative pathogenic bacteria was compared with its effect on their growth in vented and unvented stationary bottles. ... | 1991 | 2007641 |
| in vitro susceptibility of 119 yeast isolates to fluconazole, 5-fluorocytosine, amphotericin b and ketoconazole. | the in vitro activity of fluconazole was tested against 13 yeast species (119 strains) isolated from clinical specimens during a 3-month period. for comparative purposes, three other antifungal compounds (5-fluorocytosine, amphotericin b and ketoconazole) were also tested. the tests were carried out using a microautomated method previously developed in our laboratory. the method allowed us to determine the minimum inhibitory concentration (mic) of the four antifungal drugs used. for each of the ... | 1991 | 2013239 |
| disk agar diffusion susceptibility testing of yeasts. | a disk agar diffusion method was developed for testing the susceptibility of rapidly growing yeasts in vitro. a totally defined, completely synthetic agar culture medium (synthetic amino acid medium, fungal) and clinical isolates of candida spp. and torulopsis glabrata were used. turbidimetric adjustment of cell suspensions resulted in standard, reproducible inocula, which gave sharp, clear zones of inhibition when applied by an agar overlay method. optimal disk loads were determined for amphote ... | 1978 | 568910 |
| clinical comparison of the recoveries of bloodstream pathogens in septi-chek brain heart infusion broth with saponin, septi-chek tryptic soy broth, and the isolator lysis-centrifugation system. | the recoveries of microorganisms in the septi-chek biphasic tryptic soy broth (tsb) and isolator blood culturing systems were compared with the recovery in septi-chek biphasic brain heart infusion broth supplemented with the lytic agent saponin (l-bhib; roche diagnostics, division of hoffmann-la roche inc.). a total of 5,096 tsb-l-bhib blood culture sets and 1,778 isolator-l-bhib sets were evaluated. there were 435 pathogenic organisms recovered in 413 (8.1%) of the tsb-l-bhib cultures, with 348 ... | 1991 | 2056056 |
| torulopsis glabrata fungemia secondary to stone colonization. | a case of torulopsis glabrata fungemia with persistent funguria and pyelonephritis secondary to colonization of renal calculus is presented. the importance of secondary colonization of renal calculi in persistent infection and septicemia is discussed. | 1978 | 568840 |
| denture stomatitis in the elderly. | a study was carried out of 121 elderly edentulous individuals living in institutionalised homes in the lothian region, scotland to determine the prevalence of yeasts and associated oral disease. clinical examinations found that 65(54%) of the individuals suffered from denture stomatitis, and yeasts were recovered from 51(78%) of these individuals. the main yeasts isolated were torulopsis glabrata and candida albicans. culture of saliva samples produced a slightly higher recovery rate of yeasts c ... | 1990 | 2087353 |
| [in vitro sensitivity to 5-fluorocytosine and amphotericin b of yeasts of the candida genus isolated in barcelona]. | in 200 strains of candida sp, 38.5% were found to have intermediate sensitivity or to be resistant to amphotericin b and/or 5-fluorocytosine by the agar diffusion method. when the minimal inhibitory concentrations of these strains were measured, only 7.8% were resistant to amphotericin b and 2.8% to 5-fluorocytosine. the species with the highest levels of resistance were c. parapsilosis, c. tropicalis and torulopsis glabrata. candida albicans did not show resistance to 5-fluorocytosine. | 1990 | 2098147 |
| [miconazole in the treatment of systemic infection due to torulopsis glabrata]. | | 1978 | 565561 |
| killing of coccidioides immitis by hypochlorous acid or monochloramine. | to identify possible explanations for the resistance of coccidioides immitis to killing by human neutrophils, its susceptibility to typical oxidants generated during the neutrophil respiratory burst was compared to the sensitivity of other microbes. when microbial suspensions were exposed to hypochlorous acid, arthroconidia or spherules of c. immitis were killed more slowly than yeast cells of candida (torulopsis) glabrata or staphylococcus aureus. in contrast, exposure to the more lipophilic ox ... | 1990 | 2166156 |
| [comparative sensitivity of yeasts to ketoconazole, itraconazole and fluconazole using a liquid medium standardized micromethod]. | the minimal inhibitory concentrations of 200 yeast strains (48 reference strains and 152 recently isolated from pathological products) were evaluated with a new standardized micromethod using a liquid medium comparatively for ketoconazole, itraconazole and fluconazole. the ready-to-use microtitration plates contained the antifungal agents in concentrations ranging from 100 to 0.10 mg/l. the cumulative mic curves clearly showed the superiority of ketoconazole, fluconazole being the less active pr ... | 1990 | 2166937 |
| characterization of the sequence of colonization and nosocomial candidemia using dna fingerprinting and a dna probe. | the objective of this hospital-based study was to determine the relationship between colonizing and infecting strains of candida species and torulopsis glabrata. surveillance cultures from high-risk patients were paired with subsequent bloodstream isolates. organisms were typed by using restriction endonuclease digestion of chromosomal dna with bstni and ecori, followed by southern hybridization with a dna probe (pbd4) derived from saccharomyces cerevisiae. sixteen patients for whom documented c ... | 1990 | 2177750 |
| control of the yeast torulopsis glabrata in the stomachs of glucose fed lambs by oral dosing with nystatin and amphotericin "b". | in the absence of specific dietary lipids, large amounts of ethanol (ethyl alcohol) are produced from glucose in the stomachs of ruminant neonates by the resident yeast torulopsis glabrata. using new born lambs, oral dosing with the antifungal antibiotics nystatin and amphotericin "b" was shown in samples of stomach contents, to control the ethanol production entirely, and to suppress the yeast numbers partially but not permanently. of 11 lambs receiving heavy and continous doses orally of the p ... | 1977 | 558083 |
| torulopsis glabrata endophthalmitis after keratoplasty with an organ-cultured cornea. | fungal endophthalmitis developed in an elderly woman following penetrating keratoplasty with an organ-cultured cornea. an unsuccessful search was made for the source of the infection. modification in our sterility checks prior to surgery were made in hopes of preventing future infections. | 1978 | 350200 |
| growth of opportunistic yeasts on vitamin-free solid medium. | the growth of some opportunistic yeasts (candida albicans, cryptococcus neoformans, torulopsis glabrata, rhodotorula rubra, geotrichum candidum, trichosporon cutaneum, saccharomyces cerevisiae) was essayed in a solid minimal synthetic medium without vitamins. from the preliminary results some species (candida albicans, cryptococcus neoformans, rhodotorula rubra, geotrichum candidum and saccharomyces cerevisiae) seem to be autotrophic regarding the growth factor considered indispensable for their ... | 1990 | 2191196 |
| characterization of the mycoflora from oral mucosal surfaces of some hiv-infected patients. | oral mucosal surfaces from 54 patients seropositive for human immunodeficiency virus (hiv) were assayed for the presence of cultivable yeasts. oral colonization with candida albicans, represented by 6 biotypes, was evident in 35 persons. the closely related variant, candida stellatoidea, was found in 3 patients. single isolates of candida parapsilosis, candida glabrata, candida tropicalis, and candida paratropicalis were also identified. one patient harbored a population of saccharomyces cerevis ... | 1990 | 2192330 |
| systemic torulopsis glabrata infection in a neonate. | we have reported a case of neonatal torulopsis glabrata peritonitis and ventriculitis associated with a ventriculoperitoneal shunt. treatment of fungemia and ventriculitis with amphotericin b and 5-fluorocytosine was successful. | 1990 | 2196697 |
| discriminant analysis of cellular fatty acids of candida species, torulopsis glabrata, and cryptococcus neoformans determined by gas-liquid chromatography. | we used discriminant analysis of cellular fatty acid compositions determined by gas-liquid chromatography to differentiate yeastlike fungi (a total of 190 strains; including 37 candida albicans strains, 21 candida krusei strains, 13 candida guilliermondii strains, 37 candida tropicalis strains, 10 candida pseudotropicalis strains, 24 candida parapsilosis strains, 32 torulopsis glabrata strains, and 16 cryptococcus neoformans strains). previous results with a standard strain of c. albicans indica ... | 1990 | 2199515 |
| multivariate analyses of cellular carbohydrates and fatty acids of candida albicans, torulopsis glabrata, and saccharomyces cerevisiae. | quantitative data of major cellular carbohydrates distinguished candida albicans or torulopsis glabrata from saccharomyces cerevisiae but not c. albicans from t. glabrata. multivariate analyses of both carbohydrate and fatty acid variables (i. brondz, i. olsen, and m. sjöström, j. clin. microbiol. 27:2815-2819, 1989), however, differentiated all three species. | 1990 | 2203815 |
| mode of action of yeast toxins: energy requirement for saccharomyces cerevisiae killer toxin. | the role of the energy status of the yeast cell in the sensitivity of cultures to two yeast toxins was examined by using 12k release from cells as a measure of toxin action. the saccharomyces cerevisiae killer toxin bound to sensitive cells in the presence of drugs that interfered with the generation or use of energy, but it was unable to efflux 12k from the cells under these conditions. in direct contrast, the torulopsis glabrata pool efflux-stimulating toxin induced efflux of the yeast 42k poo ... | 1977 | 320190 |
| torulopsis glabrata vaginitis: clinical aspects and susceptibility to antifungal agents. | torulopsis glabrata is second only to candida albicans in frequency of isolation from the vagina in both asymptomatic women and patients with yeast vaginitis. we retrospectively studied 33 patients from whom vaginal isolates of t glabrata were obtained. torulopsis glabrata caused symptomatic vaginitis in 42% of the patients but was unassociated with symptoms in 30%; in 27% of patients, its importance was uncertain because of concomitant pathology. antifungal susceptibility testing was performed ... | 1990 | 2216197 |
| suppressive effect of 3-methylcholanthrene on phagocytic activity of mouse peritoneal macrophages for torulopsis glabrata. | the effect of 3-methylcholanthrene (mca) on the phagocytic activity of mouse peritoneal macrophages for torulopsis glabrata was investigated. macrophages were maintained in glass scintillation vials or on cover slips in leighton tubes with the use of hanks' balanced salt solution plus 30% horse serum. graded amounts of mca were incorporated into the medium and the macrophages were parasitized with viable cells of t. glabrata. macrophages from c3h mice, a strain highly susceptible to mca carcinog ... | 1979 | 285299 |
| [identification and susceptibility of clinically isolated yeast-like fungi]. | we studied the identification and susceptibility of clinically isolated yeast-like fungi at showa university hospital from april 1988 to march 1989. clinically significant of yeast-like fungi were observed in 7.1% of specimens from outpatients, 13.0% of inpatients. in both outpatients and inpatients, yeast-like fungi were isolated mainly from sputum and urine. but, one third of them were considered as non-pathogenic and not identified. the species of isolates were, candida albicans 57%, candida ... | 1990 | 2232256 |
| [in vitro antifungal activity of mercurobutol]. | mercurobutol, in its commercial form, exhibits fungistatic and fungicidal activities against both yeasts: candida albicans, c. tropicalis, torulopsis glabrata, pityrosporum spp., and filamentous fungi: dermatophytes, aspergillus fumigatus, mainly saprophytic or potentially pathogenic fungi of the cutaneo-mucous flora. minimal inhibitory concentrations on this antiseptic indicate a high susceptibility of the species tested, that could justify the enlargement of the indication of the drug to the c ... | 1990 | 2235087 |
| enhanced detection of candida in blood cultures with the bactec 460 system by use of the aerobic-hypertonic (8b) medium. | the blood culture records during the 6-year period 1984-9 were reviewed to compare the performance of the bactec aerobic (6b) and aerobic-hypertonic (8b) media for the recovery of candida spp. and torulopsis glabrata from blood. there were 137 positive blood culture sets that contained both a 6b and an 8b bottle. sixty-eight different yeasts were recovered from 65 patients including 35 candida albicans, 19 c. tropicalis, 6 c. parapsilosis, 4 c. krusei, 1 c. pseudotropicalis and 3 torulopsis glab ... | 1990 | 2249719 |
| uptake of pyrimidines and their derivatives into candida glabrata and candida albicans. | the uptake of pyrimidines and their derivatives into candida glabrata and candida albicans was measured using a novel technique in which the cells were rapidly separated from their suspending medium by centrifugation through a layer of an inert oil. the uptake of [14c]cytosine was linear for 30 s for all concentrations of pyrimidine tested. in c. glabrata but not c. albicans cytosine transport was mediated by both a high affinity (km 0.8 +/- 0.1 microm), low capacity [v 40 +/- 4 pmol (microliter ... | 1990 | 2262788 |
| reactivity of cryptococcus neoformans & candida species with concanavalin a & blood grouping sera. | forty strains of cryptococcus neoformans, 30 of candida albicans, 24 of c. parapsilosis and 10 strains each of c. tropicalis and c. (torulopsis) glabrata were examined. a 0.2 per cent solution of concanavalin a (con a) in phosphate buffered saline and commercial anti-a and anti-b blood grouping sera were used in the whole cell slide agglutination test. all the isolates of candida species strongly reacted with con a and over 90 per cent were agglutinated by anti-a and -b blood grouping sera. in c ... | 1990 | 2269512 |
| 19f nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of candida glabrata with specific defects in pyrimidine metabolism. | flucytosine (5-fc)-resistant strains were isolated from the haploid opportunistic pathogen candida glabrata by uv-induced mutation and fluoropyrimidine selection. these strains were characterized biochemically, and the metabolism of fluorinated pyrimidines was studied by 19f nuclear magnetic resonance spectroscopy. no evidence was obtained from these studies for degradative metabolism of the fluorinated derivatives. in the parental susceptible strain of c. glabrata, 5-fluorouracil but not 5-fc w ... | 1990 | 2291666 |
| in vitro susceptibility testing of candida isolates from clinical specimens to four antifungal agents. | a total of 231 isolates of candida species including 163 of candida albicans (132 of serotype a and 31 of serotype b), 42 of candida tropicalis, 17 of candida glabrata, 7 of candida parapsilosis and 2 of candida krusei were collected from clinical specimens in two medical centers, one in japan and the other in the united states. the in vitro antifungal activities of amphotericin b, 5-fluorocytosine, miconazole and fluconazole were evaluated for the above isolates by means of a photo-read broth m ... | 1990 | 2292203 |
| torulopsis glabrata infections in singapore: a 4-year study. | during the period 1971-4, torulopsis glabrata formed 42% of yeasts isolated from 5677 clinical specimens from patients with cancers, diabetes mellitus, chronic renal failure, pregnacy or major surgical operations complicated by mycotic infections. the significance of t. glabrata in these patients is discussed. | 1977 | 265338 |
| [septicemia due to torulopsis glabrata]. | the authors report a case of fungal septicemia due to torulopsis glabrata, an unusual cause of fungus infections. this case was of interest clinically in view of the duration and tenacity of the infection on a surgical unit, where repeated blood cultures were positive for torulopsis glabrata and the fungus was isolated from other samples during the same period. in the laboratory, the species identified was a common saprophyte of the mucosae and natural cavities of man; it seems to be only rarely ... | 1976 | 186871 |
| sequence of the gene for the cytoplasmic ribosomal rna small subunit from candida (torulopsis) glabrata. | | 1990 | 2336362 |
| the yeast mitochondrial atpase complex. subunit composition and evidence for a latent protease contaminant. | 1. the subunit compositions of the f1 (oligomycin-insensitive) and f1--f0 (oligomycin-sensitive) mitochondrial atpase complexes from saccharomyces cerevisiae have been examined by the highly resolving technique of sodium dodecyl sulphate-polyacrylamide slab gel electrophoresis using a discontinuous buffer system. when isolated in the presence of protease inhibitors, f1 and f1--f0 contained five and twelve bands, respectively; this contrasts with the four- and ten-band patterns seen previously us ... | 1979 | 153154 |
| fungal diarrhoea: association of different fungi and seasonal variation in their incidence. | a total of 854 patients (640 children and 214 adults) admitted with acute or chronic diarrhoea suspected of non-invasive overgrowth of fungi in intestine were screened during a period of 3 years. fungal proliferation was noted in 54.8% of these patients (53.6% in children, 58.4% in adults). the predominant fungal species isolated were candida albicans (64.5%), followed by c. tropicalis (23.3%) c. krusei (6.9%). torulopsis glabrata (1.6%). trichosporon sp. and geotrichum sp. were found to be resp ... | 1990 | 2366849 |
| the antigenic relationship between candida (torulopsis) glabrata and escherichia coli (0:75, 0:163), salmonella aberdeen o antigens. | | 1988 | 2463848 |
| [adherence of candida albicans to acrylic surfaces]. | the ability of candida albicans ifo 1385 to adhere to acrylic and the partial characterization of an adhesive substance, named as, which was isolated from the yeast, were studied in vitro. the results obtained were as follows: 1. the cells cultured in the synthetic media (ynb) containing 500 mm galactose showed a much greater tendency to adhere than did those cells cultured in the ynb containing 500 mm glucose. 2. more cells prepared by the standing cultivation adhered to acrylic than did those ... | 1989 | 2486701 |
| [in vitro activity of fluconazole, a novel bistriazole antifungal agent]. | fluconazole is a novel triazole antifungal agent with excellent activities against a broad range of medically important fungi. the in vitro antifungal activities of fluconazole especially against candida albicans were examined and the results summarized as follows: 1. fluconazole was proved to exhibit the highest antifungal activity in synthetic amino-acid medium, fungal (saamf), well buffered in a physiologically neutral range. 2. in a exposed time-killing test performed using saamf (ph 7.4), t ... | 1989 | 2540356 |
| secondary mycosis in surgery: treatment with fluconazole. | together with the severity of the underlying disease, mycotic infections are assuming increasing significance in surgical patients under intensive care. 26 patients with severe internal mycotic infections were treated with fluconazole in an open clinical trial. the pathogens isolated were candida albicans in 22 cases, candida tropicalis in four, torulopsis glabrata in three, candida parapsilosis in two and aspergillus fumigatus in one. mixed infections were found in five cases. most of this seri ... | 1989 | 2541084 |
| itraconazole vs amphotericin b: in vitro comparative evaluation of the minimal inhibitory concentration (mic) against clinically isolated yeasts. | itraconazole is a triazole compound which, following several clinical trials, has begun to be used for therapy of mycotic infections. this new drug, with a broad-spectrum antifungal activity, can be orally administered. the authors studied the in vitro susceptibility to amphotericin b and itraconazole of the following clinical isolates of pathogenic yeasts: 100 candida albicans, 20 c. tropicalis, 20 c. parapsilosis, 8 c. guilliermondii, 6 c. pseudotropicalis, 24 torulopsis glabrata and 16 crypto ... | 1989 | 2549421 |
| fluconazole treatment of candida glabrata peritonitis. | | 1989 | 2550416 |
| comparison of in vivo activity of fluconazole with that of amphotericin b against candida tropicalis, candida glabrata, and candida krusei. | fluconazole (uk-49,858) is a new oral bis-triazole antifungal agent with demonstrated activity against candida albicans. because of the increasing importance of infections due to other species of candida, we studied the efficacy of fluconazole in a rat model of established systemic candidiasis, using clinical isolates of c. tropicalis, c. glabrata, and c. krusei. in normal rats, oral fluconazole at both 20 and 80 mg/kg per day for 7 days reduced both kidney and liver titers of c. tropicalis and ... | 1989 | 2554797 |
| in-vitro effects of cilofungin (ly121019), amphotericin b and amphotericin b-deoxycholate on human polymorphonuclear leucocytes. | the in-vitro influence of cilofungin (ly121019) and amphotericin b on human polymorphonuclear leucocytes (pmns) was studied by a multifunctional approach. cilofungin at high concentration (greater than or equal to 20 mg/l) increased adherence to plastic and ingestion of staphylococcus aureus by pmns in suspension and candida albicans by adherent pmns, and slightly decreased mtt reduction and superoxide generation. amphotericin b and amphotericin b-deoxycholate decreased adherence to plastic (ic5 ... | 1989 | 2557318 |
| expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor. | the opportunistic pathogenic yeast candida glabrata elicits at least two major responses in the presence of high environmental metal levels: transcriptional induction of the metallothionein gene family by copper and the appearance of small (gamma-glu-cys)ngly peptides in the presence of cadmium. on the basis of a trans-activation selection scheme in the baker's yeast saccharomyces cerevisiae, we previously isolated a c. glabrata gene which encodes a copper-activated dna-binding protein designate ... | 1992 | 1508182 |
| [a case of intracranial germinoma responsive to amphotericin b]. | a 20-year-old man was admitted to our institution complaining of gradually worsening motor weakness in the right extremities. on admission, the radiological examination revealed a mass located in the left parietal region. on april 4, 1988, a left fronto-parietal craniotomy was performed and the tumor was subtotally removed. the pathological findings of the surgical specimen confirmed no specific tumor, but the presence of a small mingled candida glabrata supported the diagnosis of fungal granulo ... | 1992 | 1543364 |
| standardization of yeast inocula with an electronic impedance counter. | the standardization of yeast inocula has been identified as an important variable in the performance of reproducible in vitro fungal susceptibility testing. we investigated the precision and accuracy of an electronic particle counter in preparing yeast inocula, with quantitative culture used as a "gold standard." suspensions of candida albicans and torulopsis glabrata standardized with a particle counter at 10(6) counts per ml were highly reproducible when cultured quantitatively (coefficients o ... | 1989 | 2584389 |
| tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against torulopsis glabrata and candida albicans and associated increases in oxygen radical production and lysosomal enzyme release. | the capacity of human tumor necrosis factor alpha (tnf-alpha) to modulate the killing of the opportunistic pathogens torulopsis glabrata and candida albicans by human neutrophils was studied. tnf-alpha significantly enhanced neutrophil fungicidal activity in a concentration-dependent manner and was evident in a range of neutrophil-fungus ratios. enhanced killing of t. glabrata required much lower tnf-alpha concentrations than were required for enhancement of killing of c. albicans. maximal enhan ... | 1989 | 2659536 |
| disruption analysis of metallothionein-encoding genes in candida glabrata. | candida glabrata harbors multiple genes encoding metallothionein (mt). we have disrupted mt-iia, an amplified locus, and mt-iib, a single-copy gene, to determine the roles of various mt genes in cuso4 resistance in c. glabrata. the concentration of cuso4 required to inhibit the growth by 50% (ic50) of a c. glabrata strain harboring an amplified mt-iia locus and a single-copy mt-iib and mt-i genes was 7 mm in a synthetic complete medium. the ic50 decreased to approx. 1 mm when the amplified mt-ii ... | 1992 | 1339367 |
| immunologic significance of diverse specificity of monoclonal antibodies against mannans of candida albicans. | two agglutinating igm mab against mannan ag of candida albicans strains were investigated for their specificity. the agglutinating patterns of both mab with a panel of stationary phase of yeast cells of standard strains did not match those of any known polyclonal antibody (pab) factors. the reactive patterns of both mab for a given panel of 202 isolates of seven candida species and the mode of competitive binding between mab and a pab factor, as determined by a combination of direct and indirect ... | 1989 | 2681415 |
| fluconazole treatment in torulopsis glabrata upper urinary tract infection causing ureteral obstruction. | we report a case of torulopsis glabrata upper urinary tract infection causing ureteral obstruction. the infection was successfully treated with fluconazole, a new triazole derivative, combined with ureteral catheterization. | 1992 | 1552604 |
| gas chromatographic assessment of alcoholyzed fatty acids from yeasts: a new chemotaxonomic method. | an alternative chemotaxonomic method to methanolysis was developed for gas chromatographic assessment of fatty acids in whole yeast cells. clinical and reference strains of the medically important yeasts candida albicans, torulopsis glabrata, and saccharomyces cerevisiae were cultured for 48 h at 26 degrees c. cellular lysis and transesterification were then performed with ethanol, propanol, butanol, or methanol. the relative recovery rates for cellular fatty acids, including the volatile acids ... | 1989 | 2687322 |
| in vitro antifungal activity of saperconazole (r 66905) against candida and torulopsis. | the susceptibility of several strains of candida and torulopsis to saperconazole, a new triazole antifungal compound, was compared to that of ketoconazole. the mics of the two antifungal agents were determined against 70 strains of candida albicans, 10 strains of c. guilliermondii, 10 strains of c. krusei, 10 strains of c. parapsilosis, 10 strains of c. pseudotropicalis, 10 strains of c. tropicalis and 15 strains of torulopsis glabrata. the fungistatic activity was evaluated by the agar dilution ... | 1989 | 2695841 |
| orofacial fungal infections. nine pathogens that may invade during chemotherapy. | immunosuppression due to antineoplastic drugs or malignant tumor leaves patients extremely vulnerable to infection. opportunistic fungi that rarely infect healthy persons can have very severe consequences in these patients. candida albicans is the pathogen found most often, but several other candida species may cause infection as well. aspergillosis is the second most frequently seen fungal infection of the face and mouth in patients receiving chemotherapy. less commonly seen but equally dangero ... | 1992 | 1561171 |
| fungemia with torulopsis glabrata after endoscopic biliary stent replacement. | we report a patient with disseminated cholangiocarcinoma who developed systemic fungemia subsequent to endoscopic retrograde cholangiopancreatography (ercp) and stent replacement. despite intensive systemic antifungal therapy with iv amphotericin b, the patient developed multiple complications and eventually succumbed to her underlying disease. cultures of the removed stent and blood were positive for the same organism, torulopsis glabrata. in an immunocompromised host during ercp manipulation, ... | 1992 | 1615944 |
| incidence of yeasts in pregnant and non-pregnant women in nigeria. | the yeast flora of vagina and associated sites (cervix, urethra, perineum and rectum) in 224 pregnant and 106 non-pregnant nigerian women was investigated. a variety of yeasts represented by 12 species were isolated. candida albicans was the most frequently isolated species in both groups, accounting for 63.6% of the isolates from pregnant women and 44.8% of the isolates from non-pregnant women. other species of yeasts infrequently or occasionally encountered were torulopsis glabrata, c. tropica ... | 1989 | 2733724 |
| [effectiveness of selected disinfectant and antiseptic preparations on potentially pathogenic micromycetes]. | using the contact test, the author investigated the antifungal efficiency of 13 disinfectants and antiseptic preparations (hydrogen peroxide, persteril, jodonal b, jodisol, chlordetal, famosept-super, septonex, ajatin, cresolum saponatum, ethanol, desident spray, chlorhexidine, galli-valerio solution) against 23 strains of eight genera of microscopic fungi (absidia, aspergillus, candida, geotrichum, mucor, rhizopus, torulopsis and trichosporon). the results revealed that filamentous fungi and am ... | 1989 | 2736636 |
| fungemia caused by candida species and torulopsis glabrata in the hospitalized patient: frequency, characteristics, and evaluation of factors influencing outcome. | we reviewed 135 cases of candidemia occurring between 1983 and 1986 to examine oncologic and nononcologic populations and assess factors for survival. candida albicans was the most common species (51%); candida tropicalis occurred most frequently in leukemia patients (57%), whereas candida parapsilosis and torulopsis glabrata were associated with solid tumors and nononcologic diseases. risk factors identified were: preceding surgery, antibiotics, cannulas, and steroids in solid tumor and nononco ... | 1989 | 2749102 |
| [laboratory diagnostic possibilities in fungus infections in intensive care patients]. | severe yeast infections of intensive care patients are promoted by numerous predisposing factors among which antibacterial broad spectrum therapy plays an important role. since typical clinical pictures are lacking, basic procedures of mycological diagnostics are culture and differentiation of yeast strains and detection of immunological reactions against yeast antigens as well. among 200 intensive-care patients with suspected systemic mycosis, candida albicans was the prevailing yeast, followed ... | 1989 | 2764266 |
| in vitro sensitivity of candida (torulopsis) glabrata to clotrimazole. | vulvovaginitis caused by candida (torulopsis) glabrata is often refractory to intravaginal imidazole therapy. clotrimazole achieves its fungistatic activity for candida albicans and c. glabrata by inhibiting different steps in intermediary cell metabolism. for c. glabrata, alkylation precedes dimethylation. the possibility that this altered sequence might account for the relative therapeutic nonresponsiveness was studied by determining comparative minimal inhibitory concentrations (mics) of clot ... | 1989 | 2765132 |
| effect of culture media on in vitro susceptibility testing of fluconazole against some yeasts. | thirty clinical isolates, comprising six strains of candida albicans, and four strains each of c. lusitaniae, c. parapsilosis, c. tropicalis, cryptococcus neoformans, torulopsis glabrata and trichosporon beigelii were tested against fluconazole, using sabouraud's dextrose (sd) broth and a high resolution (hr) medium (pfizer central research, inc.). the procedure was a standard tube (1 ml/tube) dilution, and c. albicans y01 09 was included as a reference strain to monitor quality and reproducibil ... | 1991 | 1803235 |
| development of resistance in candida isolates from patients receiving prolonged antifungal therapy. | the impact of prolonged antifungal therapy on the development of resistance was examined in 61 patients with oropharyngeal thrush. fifty-nine patients had symptomatic human immunodeficiency virus infection, one had lung cancer, and one had metastatic prostate cancer. cultures of pharyngeal samples from all patients were positive for yeasts and included 57 (93.4%) candida albicans, 3 (4.9%) candida glabrata, and 1 (1.6%) candida krusii. of 61 patients, 32 (52.5%) were receiving or had recently re ... | 1991 | 1804002 |
| oral yeasts, mucosal health, and drug use in an elderly denture-wearing population. | drug use among the elderly may be a factor in oral mucosal pathology and the prevalence of oral yeasts. this study was designed to evaluate the relationship between oral yeast, denture-bearing mucosal health and drug use, especially drugs with known hyposalivatory side effects. there was an inverse relationship between denture-bearing mucosal health, and hyposalivatory drug use r = -0.41 p less than 0.04. use of drugs with a hyposalivatory side effect was related to increased numbers of candida ... | 1991 | 1813993 |
| [torulopsis glabrata. morphologic characteristics, biotyping and sensitivity to isolates of antifungal agents in vitro]. | the authors described morphological and biochemical properties of twenty strains of torulopsis glabrata and two strains of t. candida and t. sphaerica, mostly of human origin. by means of eight biotyping tests based on the evaluation of so-called resistograms the isolates of t. glabrata were divided into eight biotypes. the authors discussed the problem of possible use of biotyping of t. glabrata in investigations of the epidemiology and pathogenesis of mycoses caused by this microorganism. in i ... | 1991 | 1826472 |
| [torulopsis glabrata septicemia: apropos of a case]. | a 74 year's old patient with cancer of oesophagus has been operated. an atelectasis occurred just after surgery, then a septic shock with a septicaemia. blood cultures were positive with torulopsis glabrata. amphotericin b and flucytosine, followed by flucytosine and miconazole cured septicaemia. these septicaemia happen often to diabetics patients, to patients with malignant tumours, or after wide spectrum antibiotics or during prolonged parenteral nutrition or after surgery. | 1989 | 2802052 |
| evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens. | cilofungin (ly121019) is a new lipopeptide antifungal drug. we tested this drug against 141 pathogenic fungal isolates. all fungal species were tested by broth dilution at 35 degrees c. malassezia furfur was tested by agar dilution. the results demonstrate the specificity of cilofungin activity. candida albicans, candida tropicalis, and malassezia pachydermatis were highly susceptible, whereas candida parapsilosis, candida pseudotropicalis, candida krusei, torulopsis glabrata, blastomyces dermat ... | 1989 | 2802565 |
| dramatic size variation of yeast mitochondrial rnas suggests that rnase p rnas can be quite small. | the gene coding for the au-rich rna required for mitochondrial rnase p activity in saccharomyces cerevisiae codes for a 490-base rna while that in candida glabrata codes for a 227-base rna. we have detected a 140-nucleotide rna coded by the mitochondrial dna from saccharomycopsis fibuligera by hybridization with an oligonucleotide complementary to a conserved sequence found in mitochondrial and prokaryotic rnase p rnas. dna sequence analysis of the mitochondrial dna from the region coding for th ... | 1991 | 1918032 |
| preulcerative changes to the pars oesophagea associated with torulopsis glabrata infection in a weaned pig. | | 1989 | 2818364 |
| identification and characterization of mitochondrial translation products in various yeasts and in prototheca zopfii. | mitochondrial genomes of different eucaryotes are not all alike. we have examined mitochondrial translation products in a number of yeasts (candida krusei, hansenula saturnus, rhodotorula glutinis, rhodotorula rubra, torulopsis glabrata and saccharomyces cerevisiae) and in prototheca zopfii, a colorless alga, in order to determine whether certain proteins are invariably synthesized within mitochondria, how different these proteins are, and what additional proteins, if any, might be synthesized b ... | 1985 | 2836096 |
| sensitivity of intergenic regions of yeast mitochondrial dna to single-strand-specific nucleases. | the reactivity of mitochondrial dna (mtdna) sequences from torulopsis glabrata and saccharomyces cerevisiae towards single-strand-specific nucleases has been examined. at-rich stretches located in intergenic sequences from both yeasts were cleaved by nucleases when the sequences were contained in supercoiled plasmid dna. in particular ori/rep sequences from the mtdna of s. cerevisiae were shown to be sensitive to the single-strand-specific nucleases. the locations of the sensitive sites were rel ... | 1988 | 2844609 |
| effects of adenylate cyclase toxin from bordetella pertussis on human neutrophil interactions with coccidioides immitis and staphylococcus aureus. | bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic amp levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. the adenylate cyclase toxin-containing extract blocked neutrophil-mediated inhibition of n-acetylglucosamine incorporation by arthroconidia of coccidioides immitis in a dose-dependent fashion but had no effect on neutrophil phagocytosis of candida glabrata ... | 1988 | 2894360 |
| fluconazole resistance in candida glabrata. | | 1988 | 2904031 |
| periprosthetic candidal infections following arthroplasty. | candidal infection after prosthetic arthroplasty has been reported in six previous cases, to which four cases are now added. candida albicans was the offending organism in four patients, candida parapsilosis in three, candida tropicalis in two, and candida (torulopsis) glabrata in one. none of the 10 patients had evidence of disseminated candidiasis, and, except for the uniform presence of a prosthesis, other underlying factors that are generally associated with candidal infections were present ... | 1989 | 2916098 |
| rolling circle replication of dna in yeast mitochondria. | the conformation of mitochondrial dna (mtdna) from yeasts has been examined by pulsed field gel electrophoresis and electron microscopy. the majority of mtdna from candida (torulopsis) glabrata (mtdna unit size, 19 kb) exists as linear molecules ranging in size from 50 to 150 kb or 2-7 genome units. a small proportion of mtdna is present as supercoiled or relaxed circular molecules. additional components, detected by electron microscopy, are circular molecules with either single- or double-stran ... | 1991 | 1935911 |
| [acute post-stress cholecystitis and torulopsis glabrata septicemia]. | | 1987 | 2950434 |
| evaluation of the microscan rapid yeast identification panel. | the microscan rapid yeast identification (ryi) panel is a 4-h microdilution system for identification of clinical yeastlike isolates. its accuracy was evaluated by using 357 isolates encompassing 11 genera and 30 species. the ryi panel identifications were compared with those obtained by the api 20c system assisted with morphological characterization on cornmeal-tween 80 agar. the panels were read both visually and with the autoscan-4, a computer-controlled microplate reader. both the ryi panel ... | 1991 | 1939587 |
| diffuse intestinal ulceration after marrow transplantation: a clinicopathologic study of 13 patients. | the cases of 13 allogeneic marrow transplant recipients who had undergone laparotomy for manifestations of severe enteritis were reviewed to determine the causes of the severe intestinal disease and to assess the relation between clinical, histologic, and microbiologic findings. laparotomies were performed a median of 63 days (range, 11 to 273 days) after transplantation for suspected peritonitis, intestinal obstruction, or bleeding. intestinal tissue was available from small bowel resections in ... | 1986 | 3011641 |
| tolerance to and efficacy of itraconazole in treatment of systemic mycoses: preliminary results. | twelve patients with mycotic infections were treated with itraconazole during a one-year period. patients had the following conditions: coccidioidomycosis (three), histoplasmosis (three), mucocutaneous candidosis (two), aspergillosis (three), and urinary tract infection due to torulopsis glabrata (one). the daily dose of itraconazole ranged from 100 to 200 mg. ten of the 12 cases were assessable. clinical improvement was observed in six patients, two with coccidioidomycosis, two with mucocutaneo ... | 1987 | 3027852 |
| molecular probe for identification of medically important candida species and torulopsis glabrata. | a cloned dna fragment from candida albicans containing the gene for the protein actin was used to probe the molecular structure of the actin gene of several medically important yeasts (c. albicans, candida stellatoidea, candida tropicalis, candida pseudotropicalis, candida krusei, candida parapsilosis, candida guilliermondii, and torulopsis glabrata). whole-cell dna from each species was digested with restriction endonucleases, electrophoresed on agarose gels, and transferred to nitrocellulose. ... | 1987 | 3033014 |
| multicenter evaluation of four methods of yeast inoculum preparation. | we initiated a comparative study of four methods of yeast inoculum preparation: a spectrophotometric method, the wickerham card method, a hemacytometer method, and the prompt inoculation system. the variability in inoculum size obtained when each method was applied to two strains each of candida albicans, candida tropicalis, candida parapsilosis, torulopsis glabrata, cryptococcus neoformans, and saccharomyces cerevisiae was analyzed in a single laboratory. each method was performed in triplicate ... | 1988 | 3049651 |
| respiration of medically important candida species and saccharomyces cerevisiae in relation to glucose effect. | strains of medically important candida species (c. albicans, c. tropicalis, c. parapsilosis and c. [torulopsis] glabrata) and saccharomyces cerevisiae were examined for a glucose effect on respiratory activity. reduced o2-consuming ability and a relative decrease in cytochrome type c, as determined by polarography and spectrophotometry, respectively, were observed in glucose-grown s. cerevisiae cells in contrast with acetate- or ethanol-grown cells. in glucose-grown cells of c. glabrata, o2 cons ... | 1988 | 3050010 |
| cilofungin (ly121019), an antifungal agent with specific activity against candida albicans and candida tropicalis. | cilofungin (ly121019) is an antifungal agent that interferes with beta-glucan synthesis in the cells walls of fungi. the activity of this agent against 256 clinical isolates of yeasts was determined. it was found to be very active in vitro against candida albicans (mic for 90% of isolates [mic90], less than or equal to 0.31 microgram/ml; minimal fungicidal concentration for 90% of isolates [mfc90], less than or equal to 0.31 micrograms/ml) and c. tropicalis (mic90, less than or equal to 0.31 mic ... | 1988 | 3058017 |
| drug resistance in candida albicans and candida glabrata. | | 1988 | 3063171 |
| pyrolysis mass spectrometry as a method for inter-strain discrimination of candida albicans. | a claim that candida albicans strains ncpf 3153 and b311 were identical was investigated. authentic strains were shown to be distinct (p less than 0.1%) by pyrolysis mass spectrometry (pyms). of twelve strains, provided as clones of ncpf 3153, seven were authenticated, one yielded an equivocal result and four were distinct from both ncpf 3153 and b311. of eight b311 clones, six were authenticated and two yielded equivocal results. although five non-c. albicans yeast strains were identified as di ... | 1988 | 3076175 |
| growth of bacteria and fungi in total nutrient admixtures. | total nutrient admixtures (tnas) containing dextrose, amino acids, and fat emulsion were evaluated for their ability to support bacterial and fungal growth. the following solutions were tested: a standard adult total parenteral nutrient (tpn) solution with dextrose, amino acids, and electrolytes, a standard neonatal tpn solution with dextrose, amino acids, and electrolytes, a 10% fat emulsion, a 20% fat emulsion, a tna with 40% of the total calories as fat, a tna with 25% of the total calories a ... | 1986 | 3082195 |
| growth and acid production of candida species in human saliva supplemented with glucose. | growth characteristic and acid production of oral isolates of candida albicans and candida glabrata in glucose supplemented and glucose-free, pooled, human whole saliva were examined. both candida species exhibited sigmoidal growth curves in batch cultures of mixed saliva, supplemented with glucose. the growth of candida in saliva was accompanied by a rapid decline in ph from 7.5 to 3.2 over 48 h and the major acidic components initiating and sustaining this ph drop were pyruvates and acetates. ... | 1986 | 3091791 |
| rnase p rna in candida glabrata mitochondria is transcribed with substrate trnas. | the biosynthesis of some mitochondrial enzymes requires contributions of both the mitochondrial and nuclear genomes. the ribonucleoprotein enzyme ribonuclease p (rnase p) is composed of a mitochondrial encoded rna and nuclear coded protein in many yeasts, including c. glabrata. we have determined that there are at least two sites of transcription initiation that contribute to the expression of the mitochondrial rnase p rna. a nonanucleotide promoter sequence is located upstream of the initiator ... | 1991 | 1956782 |
| carriage of candida species in the oral cavity in diabetic patients: relationship to glycaemic control. | to study the possible relationship between the quality of glycaemic control in diabetes mellitus and the carriage of candida species, the candidal carrier status of 412 diabetic patients was examined using an oral rinse technique and correlated with measurements of random blood glucose and total glycosylated haemoglobin. candida was isolated in 210 diabetics (51%) with 13 patients (6%) carrying more than one species. the positive isolates were: candida albicans (89%), candida krusei (2.8%), cand ... | 1987 | 3116189 |
| evaluation of in vitro antifungal activity of ly121019. | ly121019 is a new semisynthetic lipopeptide antifungal agent with potent in vitro fungicidal activity against multiple clinical strains of candida albicans and candida tropicalis but is 10-100 fold less active against torulopsis glabrata and candida parapsilosis. its in vitro activity against candida albicans and candida tropicalis is comparable to that of amphotericin b. the in vitro fungicidal activity of this new agent supports further investigations into its use in treatment of candida infec ... | 1988 | 3132385 |
| comparative in vitro activity of ly121019 and amphotericin b against clinical isolates of candida species. | ly121019 and amphotericin b were equally active in vitro against most clinical isolates of candida albicans and candida tropicalis. higher concentrations of ly121019 were required for inhibition of candida glabrata. other candida species were inhibited by amphotericin b but not by ly121019. | 1988 | 3132386 |
| in vitro activity of ly121019 against candida species and torulopsis glabrata. | | 1988 | 3137054 |