| cp-91,243 and cp-91,244, novel diglycoside polyether antibiotics related to uk-58,852 and produced by mutants of actinomadura roseorufa. | | 1991 | 1842675 |
| adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties. | adechlorin exhibiting a potent inhibitory activity against calf intestinal adenosine deaminase was isolated from the cultured broth of actinomadura sp. omr-37. the molecular formula was c11h15n4o4cl. the aglycone of adechlorin was identical with that of the known adenosine deaminase inhibitors coformycin and 2'-deoxycoformycin. adechlorin did not exhibit inhibitory activity against various bacteria and fungi at 1.0 mg/ml. the ki values for adechlorin, coformycin and 2'-deoxycoformycin against ad ... | 1985 | 3840153 |
| potent antitumor antibiotic complex: pd 114,759, pd 115,028, pd 119,707, and pd 119,193. | four novel antitumor antibiotics (pd 114,759, pd 115,028, pd 119,707 and pd 119,193) are produced as a complex by a new species of actinomadura. the proposed name for the culture is actinomadura verrucosospora subsp. veractimyces atcc 39363. the antibiotics are extremely bioactive, with mic values of less than 0.006 ng/ml against several bacteria and id50 values of 0.003 approximately 0.107 ng/ml against l1210 leukemia cells in vitro. antitumor activities vs. p388 leukemia in vivo were observed ... | 1985 | 3840793 |
| production and properties of xylanases from thermophilic actinomycetes. | 30 strains of xylanolytic thermophilic actinomycetes were isolated from composted grass and cattle manure and identified as members of the genera thermomonospora, saccharomonospora, microbispora, streptomyces and actinomadura. screening of these strains for extracellular xylanase indicated that strains of saccharomonospora and microbispora generally were poor xylanase producers (0.5-1.5 u/ml) whereas relatively high activities were observed in cultures of streptomyces and actinomadura (4-12 u/ml ... | 1991 | 1905513 |
| 2'-chloropentostatin: discovery, fermentation and biological activity. | 2'-chloropentostatin (2-cp) is a new nucleoside antibiotic produced by actinomadura sp. atcc 39365. a selectively sensitive assay organism, enterococcus faecalis pd 05045 (mic 0.005 micrograms/ml) was instrumental in the discovery of this compound. 2-cp is a tight-binding inhibitor of adenosine deaminase (ki = 1.1 x 10(-10) m). | 1985 | 3934118 |
| [biosynthetic activity of cultures of different species of the genus actinomadura]. | the ability to synthesize antibiotics and exoproteases was studied in 13 species belonging to the actinomadura genus. the antibiotic and proteolytic activities were found only in a. fulvescens ina-3321 and a. citrea ina-1849. glycerol was shown to be the best carbon source for the growth and biosynthetic activity of a. fulvescens. a. citrea had a wider spectrum of carbon sources used for the growth and a higher proteolytic and antibiotic activity. a. citrea exerted the maximal biosynthetic activ ... | 1985 | 3937033 |
| [actinomadura species as antibiotic producers]. | screening of antibiotic-producing cultures among actinomadura showed that definite species mainly produced antibiotics of the same groups. thus, carminomycins were produced by all the 4 studied strains of a. carminata, maduramycins were produced by 3 strains of a. rubra, prodigiozines were produced by 3 strains of a. madurae and luzopeptines were produced by 6 strains of a. recticatena. supposedly, new antibiotics with original spectral characteristics were isolated from 2 strains of a. fulvesce ... | 1991 | 2053819 |
| new antitumor antibiotics, fr-900405 and fr-900406. i. taxonomy of the producing strain. | an actinomycete which was isolated from a soil sample produces new antitumor substances. the morphological and cultural characteristics of the strain resemble those of the genera streptomyces waksman and henrici 1943 and actinomadura lechevalier and lechevalier 1970. cell wall composition analysis showed that strain no. 6049 contained meso-2,6-diaminopimelic acid in its cell wall, and madurose in whole-cell sugars. no sporangia, zoospores or fragmentations of vegetative mycelium are observed. fr ... | 1985 | 4030498 |
| new antitumor antibiotics, fr-900405 and fr-900406. ii. production, isolation, characterization and antitumor activity. | the new antitumor antibiotics, fr-900405 and fr-900406, were isolated from the culture broth of actinomadura pulveracea sp. nov. no. 6049. these compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. fr-900405 and fr-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against gram-positive and gram-negative bacteria and fungi. | 1985 | 4030499 |
| structural features of cell wall teichoic acid and peptidoglycan of actinomadura cremea ina 292. | the teichoic acid from the cell wall of actinomadura cremea ina 292 has an unusual structure, being a poly(galactosylglycerol phosphate) chain with glycerol phosphate groups. monomeric units of 1-o, beta-d-galactopyranosylglycerol monophosphate are joined in the polymer by phosphodiester links involving the glycerol c3 and the galactose c6 atoms. approximately every second galactosyl substituent has a glycerol phosphate residue at its c3 atom. the teichoic acid structure was established by chemi ... | 1991 | 2070791 |
| [isolation of actinomycetales from the soil of kazakhstan on selective media with antibiotics]. | about 3000 actinomycetes were isolated from various soil samples collected in 11 regions of kazakhstan. 62.7 per cent of them proved to be antagonists. for isolation of the strains, selective media supplemented with antibiotics were used. kanamycin promoted growth of actinomadura and nocardia. rubomycin promoted growth of actinomadura. tavromycetin and roseofungin were used as selective agents for the first time. tavromycetin favoured isolation of actinomadura and nocardia. roseofungin favoured ... | 1990 | 2140036 |
| pradimicins a, b and c: new antifungal antibiotics. ii. in vitro and in vivo biological activities. | pradimicins a, b and c specify novel antibiotics produced by actinomadura hibisca no. p157-2 (atcc 53557) possessing potent and broad antifungal activity in vivo. they showed moderate in vitro antifungal activity against a wide variety of fungi and yeasts including clinically important pathogens, and were highly effective in systemic infection with candida albicans in mice after iv and im administrations. pradimicin a showed in vivo therapeutic activity against c. albicans, cryptococcus neoforma ... | 1990 | 2167304 |
| [63 cases of mycetoma in the niger republic (etiological study based on histopathology)]. | 63 samples of mycetomas were examined between 1981 and 1984. most of them (53 cases) were actinomycotic mycetomas of which 20 were due to streptomyces somaliensis, 17 to actinomadura pelletieri, 11 to nocardia sp., 4 to actinomadura madurae. the 11 mycotic mycetomas were all due to madurella mycetomi (= m. mycetomatis). | 1985 | 4085097 |
| comparison of species distribution and antimicrobial susceptibility of aerobic actinomycetes from clinical specimens. | to compare the species distribution and antimicrobial susceptibility of aerobic actinomycetes, we evaluated 366 isolates referred to the centers for disease control from october 1985 through february 1988. we used conventional biochemical tests to identify the various species. four species accounted for 191 (52%) of aerobic actinomycete isolates: nocardia asteroides (98 isolates), actinomadura madurae (42 isolates), streptomyces griseus (28 isolates), and nocardia brasiliensis (23 isolates). spu ... | 1990 | 2237117 |
| [new species of the genus actinomadura]. | | 1974 | 4444560 |
| spore formation in actinomadura dassonvillei (brocq-rousseu) lechevalier and lechevalier. | | 1974 | 4448985 |
| [micromonospora rubra sveshnikova et al. equals actinomadura rubra comb. nov]. | | 1974 | 4601020 |
| [production of antineoplastic antibiotic carminomycin by actinomadura carminata sp.nov]. | | 1973 | 4776400 |
| antibiotic ab-64, a new indicator-pigment antibiotic from actinomadura roseoviolacea var. rubescens. | | 1973 | 4792063 |
| properties of actinomadura madurae isolated from actinomycetoma with a note on taxonomy. | | 1973 | 4807201 |
| mycetoma caused by actinomadura (streptomyces) madurae. the first south african case and the results of chemotherapy. | | 1974 | 4818623 |
| prodigiosin-like pigments from actinomadura (nocardia) pelletieri. | | 1971 | 5132249 |
| a novel, cyclic, tripyrrole pigment from actinomadura (nocardia) madurae. | | 1970 | 5436614 |
| prodigiosin-like pigments from actinomadura (nocardia) pelletieri and actinomadura madurae. | thirteen red strains of actinomadura (nocardia) pelletieri and three of a. madurae were shown to produce prodigiosin-like pigments. both of the two major pigments which were observed on thin-layer chromatograms had r(f) values significantly greater than prodigiosin. the main pigment from a. madurae 953 was shown by mass and nuclear magnetic resonance spectroscopies to be nonylprodigiosin. the major pigment from a. pellitieri had a c(11)h(22) side chain in a ring form, but it was distinctly diffe ... | 1969 | 5803627 |
| a new antiviral antibiotic sf-2140 produced by actinomadura. | | 1984 | 6090375 |
| isolation and characterization of i5b2, a new phosphorus containing inhibitor of angiotensin i converting enzyme produced by actinomadura sp. | a new inhibitor of angiotensin i converting enzyme, i5b2, was isolated from the culture broth of actinomadura sp. no. 937ze-1. this compound contains n-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. the microorganism also produced another inhibitor, i5b1, which is identical with k-4 isolated from actinomadura sp. as an antihypertensive agent. | 1984 | 6094415 |
| two novel phenolics from actinomadura verrucosospora. | | 1990 | 2307621 |
| experimental antitumor activity of bmy-28175 a new fermentation derived antitumor agent. | bmy-28175 is a novel antitumor antibiotic produced in fermentation by actinomadura verrucosospora. the cytotoxic effects of bmy-28175 were determined using murine and human tumor cell lines in vitro. following 72 hour exposure, the drug had ic50 values 1.5 to 13.5 ng/ml in a microtiter assay. bmy-28175 was evaluated for antitumor activity against several experimental murine and human tumor models. the drug administered ip was active against ip implanted p388 leukemia, l1210 leukemia, b16 melanom ... | 1990 | 2345072 |
| [distribution of actinomycetes of the genus actinomadura in the light chestnut soils of volgograd province and their antagonistic properties]. | prevalence of the actinomycetes of the actinomadura genus in the virgin and cultivated light chestnut soils of the volgograd region was studied. it was shown that actinomadura were one of the constituents of the actinomycetous flora of these soils. no significant changes in the number of the actinomadura and the total number of the actinomycetes were observed in the cultivated and virgin soils. the cultures of actinomadura isolated from the virgin and cultivated soils belonged to 17 and 18 known ... | 1982 | 6217783 |
| nucleotide sequence of the gene encoding the active-site serine beta-lactamase from actinomadura r39. | the gene encoding the extracellular, active-site serine beta-lactamase of actinomadura r39, previously cloned into streptomyces lividans, has the information for the synthesis of a 304 amino acid protein, the amino terminal region of which has the characteristic features of a signal peptide. the actinomadura r39 beta-lactamase is another member of the class a beta-lactamases. in particular, it shows high homology with the beta-lactamase of bacillus licheniformis. | 1989 | 2515104 |
| [recurrence of a mycetoma due to actinomadura madurae with visceral and lymph node involvement]. | | 1986 | 3579115 |
| enzymatic preparation of an immunostimulant, the disaccharide-dipeptide, n-acetyl-beta-d-glucosaminyl-(1----4)-n-acetylmuramyl-l-alanyl-d-is ogl utamine, from a bacterial peptidoglycan. | the disaccharide-dipeptide n-acetyl-beta-d-glucosaminyl-(1----4)-n-acetylmuramyl-l-alanyl-d-isog lut amine has been obtained by an enzymatic degradation of the peptidoglycan of actinomadura r39. the peptidoglycan was hydrolyzed successively by the three following enzymes: lysozyme, dd-carboxypeptidase from streptomyces albus g and gamma-d-glutamyl-meso-diaminopimelate endopeptidase i from bacillus sphaericus 9602. the by-products of the last reaction were eliminated by successive ion-exchange an ... | 1984 | 6381058 |
| [incidence of actinomycetes of the genus actinomadura in the soils of kazakhstan]. | | 1981 | 6455088 |
| [actinomadura of the sierozem soils of turkmenia and their antagonistic properties]. | occurrence of actinomycetes of the genus actinomadura in the grey earth soils of turkmenistan was studied. the gause organic medium no. 2 with rubomycin proved to be most favourable for isolation of actinomadura from the soil samples. the number of actinomadura in 1 g of the soil varied from 3 to 686 000 depending on the sample which constituted 0.2-11 per cent of the total number of the actinomycetes. it was shown that actinomadura are rather widely distributed in the grey earth soils of turkme ... | 1981 | 6458232 |
| [new species of actinomadura isolated from soils in turkmenia and their antagonistic properties]. | new species, i.e. actinomadura polychroma and actinomadura umbrina are described. the cell wall of the cultures contains meso-diaminopimelic acid galactose, glucose and madurose. the former species is characterized by short spore chains in the form of spirals or pseudosporangia, smooth spore surface, white aerial mycelium and colourless, yellowish-brown or blue-green substrate mycelium. the cultures of this species have no antagonistic activity with respect to various test-microbes. the type cul ... | 1981 | 6459758 |
| [new species, actinomadura fulvescens sp. nov. and actinomadura turkmeniaca sp. nov. and their antagonistic properties]. | two new species of actinomadura isolated from soil samples of the turkmen ssr, i.e. actinomadura fulvescens sp. nov. and actinomadura turkmeniaca sp. nov. are described. the first species is characterized by formation of short (1-2 turns) spiral spore chains, smooth spores, scanty white aerial mycelium, colourless or yellowish substrate mycelium on synthetic media and brownish-yellow substrate mycelium and soluble pigment of the same colour on organic media. no melanoid pigment is secreted. the ... | 1982 | 6461291 |
| cl 259,971: a potent new polyether anticoccidial. 1. battery efficacy and safety. | the anticoccidial activity of cl 259,971, a new polyether ionophore produced by actinomadura yumaense sp. nov, has been demonstrated against six species of poultry eimeria, tested individually or in mixed species infections. statistically significant activity was obtained against some species with as little as 2.5 ppm of drug. the optimal treatment level, however, was determined to be 5 ppm. at this level, performance was comparable to 100 or 120 ppm of monensin. cl 259,971 is coccidiocidal and ... | 1984 | 6483715 |
| parvodicin, a novel glycopeptide from a new species, actinomadura parvosata: discovery, taxonomy, activity and structure elucidation. | an extensive taxonomic investigation identified strain sk&f-aaj-271 as a new species, designated actinomadura parvosata. fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. structures for seven of the isolated components were derived from a combination of mass spectral, high-field nmr and chemical techniques. the o-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of ... | 1987 | 3624076 |
| a new indole n-glycoside antibiotic sf-2140 from an actinomadura. i. taxonomy and fermentation of producing microorganism. | a new indole n-glycoside antibiotic sf-2140 which shows antiviral and weak antibacterial activity has been obtained from the cultured broth of an actinomycete strain. strain sf-2140, designated actinomadura albolutea sp. nov., was isolated from a soil sample collected in hyogo prefecture, japan. | 1984 | 6548734 |
| [teichoic acid from the cell wall of actinomadura carminata--a producer of the antibiotic carminomycin]. | the cell walls of actinomadura carminata, producing the antibiotic carminomycin, contain a poly(glycerol phosphate) teichoic acid. the polymer belongs to 1,3-type and consists of about 8 glycerol phosphate units, two of them have 2-acetamido-2-deoxy-alpha-d-galactopyranosyl substituent and one--3-o-methyl-beta-d-galactopyranosyl-(1----3)-2- acetamido-2-deoxy-alpha-d-galactopyranosyl residue at c2 of glycerol. the structure of the polymer was established by chemical analysis and 13c-nmr spectrosc ... | 1986 | 3730009 |
| butylmaduramycin, a new antibiotic from actinomadura rubra. | butylmaduramycin, a new derivative of maduramycin was isolated from the culture medium of a mutant strain of actinomadura rubra. this communication describes some biological and physico-chemical characteristics of the new antibiotic. | 1986 | 3746628 |
| mouse toxicity induced by lipids and cell walls isolated from actinomycetes. | the possibility was examined that the toxicity induced in mice by actinomadura madurae, 'streptomyces pelletieri' and nocardia brasiliensis was due to lipid and cell-wall constituents. mice were inoculated intraperitoneally with heat-killed bacteria, lipid extracts and cell-wall preparations emulsified in mineral oil: toxicity was evaluated by recording weight loss and deaths. killed cells and cell-wall preparations of all three actinomycetes produced a pronounced loss of body weight, tissue nec ... | 1986 | 3794660 |
| a new species of actinomadura producing a polyether antibiotic, cationomycin. | taxonomic studies on the new species, actinomadura azurea are presented. a significant property of this species is the production of a new polyether antibiotic, cationomycin. | 1983 | 6654756 |
| a serological survey of antibodies to streptomyces somaliensis and actinomadura madurae in the sudan enzyme linked immunosorbent assay (elisa). | sera from 160 individuals resident in the gezira, and 40 living in khartoum, sudan, were screened for antibodies to streptomyces somaliensis and actinomadura madurae using enzyme linked immunosorbent assay (elisa). antibodies were detected in 11.2% of those from the gezira (6.8% to s. somaliensis, 4.3% to a. madurae, and 0.6% to both) compared to 2.5% of those resident in khartoum. the ratio of men with antibodies compared to women was about 2:1 in those from gezira. the results encouraged furth ... | 1983 | 6679364 |
| [new species of actinomadura recticatena sp. nov. and its antibiotic properties]. | actinomadura cultures were isolated from soil samples collected in turkmenistan, the moscow, kursk and volgograd regions. the cultures were described as representatives of a new species (actinomadura recticatena, preobrazhenskaya et galatenko, sp. nov). the hydrolysates of intact cells of the cultures contain mesodiaminopumelic acid, galactose and madurose. the species is characterized by straight spore chains, wrinkled spore surface, cream-colored aerial mycelium and brown substrate mycelium wi ... | 1984 | 6696399 |
| mycetoma of the scalp: report of a case. | mycetoma of the scalp in a 10-year-old boy is reported. this is the first report of this infection in the eastern province of saudi arabia. the causative agent, actinomadura madurae, has already been described in the kingdom and shown by other workers to affect other parts of the body. the probable pathogenesis is discussed and the need to increase clinical awareness of the condition stressed. | 1986 | 3798535 |
| immunodiffusion studies of some nocardia strains. | forty-three strains of nocardia, one of actinomadura and two of nocardiopsis were studied using the comparative immunodiffusion technique. three reference precipitation systems were employed: one represented nocardia asteroides n10, one n. asteroides atcc 19247, and one n. otitidis-caviarum atcc 14629. one tight cluster was formed by the n. otitidis-caviarum strains and another tight cluster was formed by some of the n. asteroides strains studied. however, other strains of n. asteroides were dis ... | 1981 | 6798166 |
| madura foot by actinomadura madurae. a further report on an autochthonous italian case. | | 1983 | 6888420 |
| biotyping of aerobic actinomycetes by modified killer system. | forty-four yeasts belonging to the genera pichia, candida, saccharomyces and kluyveromyces were tested for their potential killer effect on 13 aerobic actinomycetes (6 nocardia asteroides, 1 n. brasiliensis, 1 n. caviae and 5 actinomadura madurae). only a few yeast strains did not display any killer activity against the aerobic actinomycetes studied, thus confirming that the killer phenomenon is widespread among microorganisms. for epidemiological purposes, a killer system was developed. accordi ... | 1988 | 3281858 |
| mycetoma in the republic of niger: clinical features and epidemiology. | mycetoma is a common disease in the republic of niger. in two hospitals 133 cases were observed. the major site of lesions was the foot. actinomycetomata were seen more often than eumycetomata. streptomyces somaliensis is prevalent in the north desert zone while actinomadura pelletieri is common in the southern part of the country. madurella mycetomatis, the usual etiologic agent of eumycetoma, is seen in both regions. the species incidence and distribution in niger differs from those of the wes ... | 1988 | 3354772 |
| menaquinone composition in the classification and identification of aerobic actinomycetes. | menaquinones were the only isoprenoid quinones found in 36 strains representing different species of the genera nocardia, mycobacterium, rhodococcus, amycolatopsis, saccharothrix, streptomyces, nocardiopsis and actinomadura. dihydrogenated menaquinones with nine isoprene units [mk-9(h2)] were the main components isolated from mycobacterium. dihydrogenated and tetrahydrogenated menaquinones with eight isoprene units were the predominant compounds identified in typical rhodococcus and nocardia str ... | 1988 | 3376615 |
| delta 2- and delta 3-cephalosporins, penicillinate and 6-unsubstituted penems. intrinsic reactivity and interaction with beta-lactamases and d-alanyl-d-alanine-cleaving serine peptidases. | the intrinsic reactivity of delta 2- and delta 3-deacetoxy-7-phenylacetamidocephalosporanates, penicillanate, unsubstituted, 2-methyl- and 2-phenyl-penems and other beta-lactam antibiotics has been expressed in terms of the second-order rate constant (m-1.s-1(oh-)) for the hydrolysis of the beta-lactam amide bond by oh- at 37 degrees c. the values thus obtained have been compared with the second-order rate constants (m-1.s-1(enzyme) for the opening of the same beta-lactam amide bond during inter ... | 1982 | 6980645 |
| interaction of clavulanate with the beta-lactamases of streptomyces albus g and actinomadura r39. | the reactions of beta-lactamases of actinomadura r39 and streptomyces albus g with clavulanate proceed along branched pathways. both enzymes perform the hydrolysis of this beta-lactam with rather high efficiencies (kcat. = 18s-1 and 52s-1 respectively). if large clavulanate/enzyme ratios are used, complete inactivation of the enzymes is observed. at lower ratios, inactivation is only partial. irreversible inactivation occurs after 400 and 20000 turnovers for the a. r39 and s. albus g enzymes res ... | 1982 | 6984651 |
| [the antineoplastic antibiotic polypeptide 308 produced by actinomadura recticatena. its isolation and physicochemical properties]. | a antitumor antibiotic belonging to the group of polypeptide antibiotics containing chromophore was isolated from the culture of actinomadura recticatena terekhova, preobrazhenskaya et galatenko, 1984, strain 308. biosynthesis, isolation, physicochemical and biological properties of the antibiotic are described. the results of elemental analysis, the melting point, optical properties, uv, ir and nmr spectra and the data on acid hydrolysis showed that antibiotic 308 was most closely related to an ... | 1988 | 3421765 |
| [composition and structure of the antibiotic polypeptide 308-i from actinomadura recticatena]. | antibiotic 308-i isolated from actinomadura recticatena and the products of its degradation were studied with the methods of electron impact mass spectrometry, chemical ionization with ammonia, field desorption and ion extraction from solution under atmospheric pressure. it was shown that by its composition and structure antibiotic 308-i was identical to antibiotic bbm-928 a. | 1988 | 3421766 |
| baumycin analogs isolated from actinomadura sp. | | 1981 | 7053087 |
| [transfer of species of the genus actinomadura lechevalier et lechevalier 1970 to the genus nocardiopsis meyer 1976]. | the type cultures of four actinomadura species (a. africana, a. coeruleofusca, a. flava, a. longispora) were studied and compared with the type culture belonging to the genus nocardiopsis. in their morphological properties and in the composition of the cell wall, these cultures were shown to be closer to the genus nocardiopsis meyer 1976 rather than to the genus actinomadura lechevalier et lechevalier 1970. basing on these data, the species have been transferred to the genus nocardiopsis. | 1982 | 7070303 |
| actinomycetoma of the mandibular region causing ankylosis. | a case of mycetoma of the mandibular region caused by actinomadura madurae is presented. diagnostic procedures and rationale for treatment are discussed. in tropical and subtropical areas where mycetoma is endemic it should be included in the differential diagnosis of tumours of the facio-maxillary region. | 1987 | 3474024 |
| sporotrichosis-like mycetoma caused by actinomadura madurae. | | 1982 | 7133047 |
| examination of model enzyme and penetration systems in relation to antibacterial activity. | recent work has shown that the activity of cephalosporins in inhibiting exocellular dd-peptidases from streptomyces r61 and actinomadura r39 are, at best, only poorly related to minimum inhibitory concentrations against pathogenic isolates. taking into account the rate at which cephalosporins diffuse through porin channels, such as exist in certain gram-negative organisms, does not help in establishing a relationship between mic data and the kinetic data on the model enzymes. most published cell ... | 1986 | 3485626 |
| mycetoma in saudi arabia. | the clinical and microbiological features of 31 cases of mycetoma seen in 8 years at a riyadh hospital are described. eighteen were due to streptomyces somaliensis, 10 to madurella mycetomatis and one each to actinomadura madurae, nocardia asteroides, and an unidentified species of cladosporium. no immune defects were detected in the patients. eleven had osteolytic lesions and 17 required surgery. only seven patients were cured. streptomyces infections were seen from all parts of saudi arabia ou ... | 1987 | 3550122 |
| a clinico-pathological study of actinomycotic mycetomas caused by actinomadura madurae and actinomadura pelletierii. | twenty seven cases of actionomycotic mycetoma caused either by actinomadura madurae or actinomadura pelletierii have been described. infection by a. madurae has been more common than a. pelletierii. left foot in a. madurae and right foot in a. pelletierii infections were involved more commonly in adult males, whereas right foot of the females was frequently affected in a. madurae infection. large, soft, white grains in a. madurae and small, firm, red grains in a. pelletierii were consistently se ... | 1987 | 3574438 |
| [enzyme inhibitors from actinomycetes. ii. acid protease inhibitors]. | in the course of a screening program directed toward the isolation and evaluation of inhibitors of carboxyl (acid) proteinases, we have found 0.39% of the investigated strains of microorganisms as producers of pepsin inhibitors. in more than 1543 strains which were isolated from various geographical areas and deposited with the imet culture collection, jena-gdr, and which belong to different genera of actinomycetes such as streptomyces, actinomadura, actinoplanes, micromonospora and non-identifi ... | 1985 | 3930695 |
| porcine abortions associated with fungi, actinomycetes, and rhodococcus sp. | history, lesions, and results of microbiologic examinations are given for four porcine abortions associated with fungi and one each associated with actinomadura madurae, an aerobic actinomycete, and rhodococcus sp. the fungi were gliomastix sp., petriellidium boydii, aspergillus fumigatus, and exophiala jeanselmei. parvovirus, isolated from one fetus, was the only other infectious agent identified. the presence of fungi, actinomadura madurae, and rhodococcus sp. in fetal and placental lesions in ... | 1981 | 7281459 |
| the penicillin-binding site in the exocellular dd-carboxypeptidase-transpeptidase of actinomadura r39. | heat denaturation and pronase degradation of the complex previously formed between benzylpenicillin and the exocellular dd-carboxypeptidase-transpeptidase of actinomadura r39 yields a heptapeptide h-leu-pro-ala-ser-asn-gly-val-oh, where the benzylpenicilloyl group is ester-linked to the serine residue. this linkage is very labile and its hydrolysis causes the release of benzylpenicilloate. in contrast, the native benzylpenicilloyl-enzyme complex is very stable (half-life 70 h at 37 degrees c) an ... | 1981 | 7305936 |
| cationomycin, a new polyether ionophore antibiotic produced by actinomadura nov. sp. | | 1981 | 7319913 |
| determination of fatty acids of the bacteria streptomyces r61 and actinomadura r39 by capillary gas chromatography-mass spectrometry. | | 1985 | 4019678 |
| actinomadura pelletieri mycetoma from the transvaal. a case report. | the osteophilic red grain mycetoma due to actinomadura pelletieri is rare in southern africa. this report describes an elderly patient with extensive bone involvement in which lymphatic spread to the inguinal lymph nodes had occurred. the diagnosis and management are discussed. | 1985 | 4035517 |
| [spontaneous l-transformation in actinomycetes]. | spontaneous l-transformation was described in actinomadura and nocardiopsis. cultures growing for two days were found to contain polymorphous cells (0.5 to 1.5 mum) lacking a cell wall. a considerable portion of the cell is occupied with a nucleoid while the cytoplasm is forced toward the periphery of the cell. membranous structures formed by five-layer membranes can be seen in the cytoplasm. budding has been observed. the above features are typical of bacterial l-forms and has not been found in ... | 1981 | 7329357 |
| bbm-928, a new antitumor antibiotic complex. ii. taxonomic studies on the producing organism. | an actinomycete strain no. g455-101 isolated from a soil sample collected in luzon island, philippines produced a new antitumor antibiotic complex bbm-928. the organism was determined to be a new species of the genus actinomadura and designated actinomadura luzonensis nov. sp. the type strain, no. g455-101, has been deposited under the number atcc 31491. | 1980 | 7451358 |
| [distribution of teichoic acids in cultures of the genus actinomadura]. | the occurrence of teichoic acids in cultures of actinomadura genus was studied. all 30 strains examined in this survey contained alditol phosphate polymers. most of the cultures had poly(glycerol phosphate) teichoic acids. some of the poly(glycerol phosphate) chains bear madurose as a glycosyl substituent. in seven cultures glycerol teichoic acids with an unusual localization of the phosphodiester linkage were detected. ribitol teichoic acids were found in six organisms. | 1985 | 4058323 |
| production of trehalose phosphorylase by catellatospora ferruginea. | a range of microorganisms was screened for new and high producer strains of trehalose phosphorylase (ec 2.4.1.64). trehalose phosphorylase activity was found in cells of actinomyctes of the genera actinomadura, amycolata, catellatospora, kineosporia, and nocardia. among them, catellatospora ferruginea showed the highest enzyme activity. trehalose phosphorylase from c. ferruginea was able to catalyse both the phosphorolysis of trehalose into beta-glucose 1-phosphate and d-glucose and the synthesi ... | 1995 | 7557309 |
| breakdown of the stereospecificity of dd-peptidases and beta-lactamases with thiolester substrates. | with peptide analogues of their natural substrates (the glycopeptide units of nascent peptidoglycan), the dd-peptidases exhibit a strict preference for d-ala-d-xaa c-termini. gly is tolerated as the c-terminal residue, but with a significantly decreased activity. these enzymes were also known to hydrolyse various ester and thiolester analogues of their natural substrates. some thiolesters with a c-terminal leaving group that exhibited l stereochemistry were significantly hydrolysed by some of th ... | 1995 | 7626006 |
| kinetic study of interaction between brl 42715, beta-lactamases, and d-alanyl-d-alanine peptidases. | a detailed kinetic study of the interactions between brl 42715, a beta-lactamase-inhibiting penem, and various beta-lactamases (ec 3.5.2.6) and d-alanyl-d-alanine peptidases (dd-peptidases, ec 3.4.16.4) is presented. the compound was a very efficient inactivator of all active-site serine beta-lactamases but was hydrolyzed by the class b, zn(2+)-containing enzymes, with very different kcat values. inactivation of the streptomyces sp. strain r61 extracellular dd-peptidase was not observed, and the ... | 1995 | 7695311 |
| pradimicin s, a new pradimicin analog. iii. application of the frit-fab lc/ms technique to the elucidation of the pradimicin s biosynthetic pathway. | the biosynthetic pathway of pradimicin s (prm-s) was investigated by using sinefungin and bioconversion experiments with aglycones of pradimicin a (prm-a) and actinomadura spinosa aa0851, a prm-s producer. addition of sinefungin to the strain inhibited the formation of 11-o-demethyl-7-o-methylpradinone ii (11dm-7m-pnii) as also determined to occur with its addition to the prm-a producer. in feeding prm-a aglycone and its analogs to the strain early in prm-s biosynthesis, good identifications of ... | 1995 | 7706128 |
| a new antibiotic sf-2370 produced by actinomadura. | | 1985 | 4066497 |
| a novel macromolecular antibiotic, sn-07. taxonomy of producing organism, isolation, characterization and biological activities. | a novel macromolecular antibiotic sn-07 was obtained from the cultural supernatant of actinomadura roseoviolacea var. miuraensis nov. var. the antibiotic was soluble in water, had a molecular weight of 18,000-22,000 daltons in 50 mm tris-hcl buffer, ph 7.0, containing 2.0 m kcl as compared with authentic proteins. its major constituents were nucleic acids. the substance had antibacterial activity against gram-positive bacteria. it was also effective against lymphocytic leukemia p388 in vivo. | 1985 | 4093331 |
| matlystatins, new inhibitors of type iv collagenases from actinomadura atramentaria. iii. structure elucidation of matlystatins a to f. | the structures of matlystatins, novel type iv collagenase inhibitors isolated from actinomadura atramentaria, have been determined by a systematic application of homo- and heteronuclear 2d nmr and fab-ms/ms techniques. their structures were characterized by the presence of piperazic acid and hydroxamic acid moieties, structural motifs often seen in protease inhibitors. | 1994 | 7844042 |
| matlystatins, new inhibitors of type iv collagenases from actinomadura atramentaria. iv. synthesis and structure-activity relationships of matlystatin b and its stereoisomers. | the first total synthesis of matlystatin b (1a), a low molecular weight inhibitor of type iv collagenases, was accomplished, and its absolute configuration was unambiguously determined. furthermore, ten stereoisomers of 1a were synthesized, and the inhibition of the 92 kda type iv collagenase and of other metalloproteinases by each stereoisomer was investigated. | 1994 | 7844043 |
| biosynthesis of the antibiotic maduramicin. origin of the carbon and oxygen atoms as well as the 13c nmr assignments. | the biosynthesis of maduramicin alpha and beta in a culture of actinomadura yumaensis has been studied using 13c, 14c and 18o labeled precursors. the alpha component of this recently discovered polyether antibiotic, containing forty-seven carbon atoms in a seven-ring system, is derived from eight acetate, seven propionate and four methionine molecules. the beta component which is missing one methoxy group incorporates three methionine methyl groups. the carbohydrate moiety was enriched by methio ... | 1984 | 6526733 |
| des-, syn- and anti-oxyimino-delta 3-cephalosporins. intrinsic reactivity and reaction with rtem-2 serine beta-lactamase and d-alanyl-d-alanine-cleaving serine and zn2+-containing peptidases. | the presence and configuration (syn or anti) of an oxyimino group in the 7 (beta)-acyl side chain of 3-cephems do not modify the intrinsic reactivity of the beta-lactam ring, but have highly enzyme-specific effects. when compared with the corresponding desoxyimino beta-lactam compound: (i) with the plasmid-mediated escherichia coli rtem-2 serine beta-lactamase, the substrate activity of the anti isomer is increased and that of the syn isomer is decreased; (ii) with the streptomyces r61 serine d- ... | 1984 | 6609701 |
| numerical classification of streptomyces and related genera. | four hundred and seventy-five strains, which included 394 type cultures of streptomyces and representatives of 14 other actinomycete genera, were studied. overall similarities of these strains for 139 unit characters were determined by the ssm and sj coefficients and clustering by the upgma algorithm. test error and overlap between the phena defined were within acceptable limits. cluster-groups were defined by the ssm coefficient at the 70.1% similarity (s) level and by the sj coefficient at the ... | 1983 | 6631406 |
| red grain mycetoma caused by actinomadura pelletieri in western rajasthan: report of two cases. | | 1993 | 8157323 |
| microbial modification of pradimicins at c-11 leading to 11-o-demethyl- and 11-o-l-xylosylpradimicins a and fa-1. | in a screen of pradimicin-nonproducing mutants derived from actinomadura verrucosospora subsp. neohibisca r103-3, we found a strain capable of producing 11-hydroxyl analogs of pradimicins a and fa-1, designated pradimicins h and fh, respectively. feeding of pradimicins h and fh to growing cultures of an actinomycete strain aa3798 produced 11-o-l-xylosylpradimicins h and fh, respectively. these 11-o-l-xylosylpradimicins had a broad spectrum of antifungal activity and demonstrated in vivo efficaci ... | 1993 | 8244888 |
| sugar-containing lipids in the classification of representative actinomadura and nocardiopsis species. | the major sugar-containing lipids of some actinomadura and nocardiopis strains--recognized as an important agent of actinomycetoma -- were analyzed by thin-layer and gas-liquid chromatography. it was demonstrated that nocardiopsis dassonvillei strains contained two characteristic glycolipids identified as monomannosyl diglyceride and monoacylated glucose. none of them was found in the representatives of actinomadura madurae and actinomadura pelletieri strains, which possessed phosphatidylinosito ... | 1983 | 6651478 |
| thiazohalostatin, a new cytoprotective substance produced by actinomadura. i. taxonomy, production, isolation and biological activities. | thiazohalostatin has been isolated from the culture broth of actinomadura sp. by a screening program designed to find novel cytoprotective substances. it was purified by use of column chromatography on silica gel, reversed phase hplc and then isolated as colorless powder. thiazohalostatin prevented cell death caused by calcium overload and exhibited an inhibitory activity against lipid peroxidation. | 1993 | 8270483 |
| thiazohalostatin, a new cytoprotective substance produced by actinomadura. ii. physico-chemical properties and structure determination. | thiazohalostatin is a new cytoprotective substance produced by actinomadura sp. hq24. its structure was elucidated as shown in fig. 1 by nmr spectral analyses and chemical modifications. thiazohalostatin was found to possess a novel skeleton containing trichloropyrrole and thiazoline ring moieties. | 1993 | 8270484 |
| oxanthromicin, a novel antibiotic from actinomadura. | | 1984 | 6725146 |
| verucopeptin, a new antitumor antibiotic active against b16 melanoma. i. taxonomy, production, isolation, physico-chemical properties and biological activity. | a new antitumor antibiotic verucopeptin was isolated from the culture broth of actinomadura verrucosospora q886-2. it should potent cytotoxicity and specific in vivo activity against b16 melanoma. maximum t/c value (162%) was obtained by q1d x 1 treatment schedule. | 1993 | 8344873 |
| diagnostic problems with imported cases of mycetoma in the netherlands. | eight cases of imported mycetomata in the netherlands are reviewed. seven of these were cultured; only one isolate, actinomadura madurae, belonged to a species commonly known as an agent of mycetoma. the remaining strains either belonged to very rare species, such as phialophora cyanescens, or could not be identified at all. the list of possible agents of mycetoma apparently needs to be expanded. in addition, the concept of endemic occurrence of aetiological agents of eumycetoma needs revision. ... | 1993 | 8366880 |
| purification and properties of the exocellular beta-lactamase of actinomadura strain r39. | the exocellular beta-lactamase (penicillin amido-beta-lactamhydrolase, ec 3.5.2.6) of actinomadura r39 consists of one single polypeptide chain of molecular weight about 15 200. it exhibits a highly asymmetrical shape, has a low isoelectric point (at ph 5.0) and contains about 9.3% (w/w) of a polydeoxyribonucleotide with which it forms a rather stable complex. removal of a substantial amount of this deoxyribonucleotide by treatment with dnaase i has no effect on the enzyme activity. the beta-lac ... | 1982 | 6976797 |
| a taxonomic review of the genus microbispora by analysis of ribosomal protein at-l30. | we analyzed the ribosomal at-l30 proteins from 13 type strains of species belonging to the genera microbispora and actinomadura. the electrophoretic mobilities of the at-l30 preparations from microbispora strains, as determined by two-dimensional polyacrylamide gel electrophoresis, revealed that the members of the genus microbispora are phylogenetically homogeneous. the results of partial amino acid sequencing of at-l30 preparations from several representative microbispora strains supported the ... | 1993 | 8427809 |
| interactions between non-classical beta-lactam compounds and the beta-lactamases of actinomadura r39 and streptomyces albus g. | 6-aminopenicillanic acid, 7-aminocephalosporanic acid, mecillinam and quinacillin have varying substrate activities for both the r39 beta-lactamase (excreted by actinomadura r39) and the g beta-lactamase (excreted by streptomyces albus g). cefoxitin and quinacillin sulphone are not recognized by the g beta-lactamase and are weak inactivators of the r39 beta-lactamase. n-formimidoylthienamycin is a poor substrate for the g beta-lactamase and a potent inactivator of the r39 beta-lactamase. the hig ... | 1981 | 6978132 |
| bms-181184, a new pradimicin derivative. screening, taxonomy, directed biosynthesis, isolation and characterization. | bms-181184 is a new semisynthetic pradimicin derivative with a broad-spectrum antifungal activity. in a search for actinomycetes producing bms-181184, 4 strains of actinomadura sp. isolated from soil samples were found to produce the antibiotic under conditions of directed biosynthesis. among them, actinomadura sp. ab1236 proved most useful in the production of bms-181184 when fermented in a medium containing d-serine and d-cycloserine. a minor product isolated from the broth of strain ab1236 wa ... | 1993 | 8468241 |
| actinomycetoma in the united states. | actinomycetoma (madura foot) caused by actinomadura madurae occurred in an indiana factory worker. previous cases of culture-proven actinomycetoma from the united states and reports of drug therapy were reviewed. treatment with sulfonamides, streptomycin, dapsone, and other antimicrobial agents has been effective. trimethoprim-sulfamethoxazole (tmp-smz) therapy was effective in our case, but sulfadiazine was not. in vitro, smz was 16 times more active against the infecting strain of a. madurae t ... | 1981 | 6979082 |
| survey of human pathogenic actinomycetes and fungi in soil from rome and other italian areas. | as part of a study sponsored by the ministry of health of italy, a research program on pathogenic actinomycetes, keratinophilic and pathogenic fungi in soil was carried out. two hundred soil samples, collected from different areas of the city of rome, calabria, emilia romagna, latium, apulia, sardinia, sicily, tuscany and umbria, were examined by several techniques to detect the widest possible variety of pathogenic actinomycetes and fungi. seven isolates of nocardia asteroides, four of actinoma ... | 1981 | 7012635 |
| studies on the primary structures of the exocellular d-alanyl-d-alanine peptidases of streptomyces strain r61 and actinomadura strain r39. | the mr 37 000 d-alanyl-d-alanine peptidase excreted by streptomyces r61 and the mr 53 000 d-alanyl-d-alanine peptidase excreted by actinomadura r39 are both characterized by a very uneven distribution of the basic (arg + lys) amino acid residues. trypsin degradation of the heat-denatured enzymes generates (1) thirteen soluble peptides which contain from 2 to 28 residues in the case of the r61 enzyme and nineteen soluble peptides which contain 2 to 39 residues in the case of the r39 enzyme; and ( ... | 1981 | 7034781 |
| biosynthesis of the pradimicin family of antibiotics. ii. fermentation, isolation and structure determination of metabolites associated with the pradimicins biosynthesis. | ten metabolites produced by 4 mutants derived from actinomadura verrucosospora subsp. neohibisca e-40, a high pradimicins producer, were isolated and their structures were determined. strain jn-219 produced 3 novel analogs of the pradimicin a aglycone, i.e. 11-o-demethyl-7-methoxypradinone ii and 11-o-demethylpradinones i and ii together with a known aglycone analog, pradinone i, while the metabolites from strain jn-47 were determined to be 2 new aglycone analogs, 11-o-demethylpradimicinone i an ... | 1993 | 8478260 |
| biosynthesis of the pradimicin family of antibiotics. iii. biosynthetic pathway of both pradimicins and benanomicins. | the biosynthetic pathway of the pradimicin-benanomicin family of antibiotics was investigated by using sinefungin and blocked mutants derived from actinomadura verrucosospora subsp. neohibisca e-40 (a high pradimicin producer) or actinomadura sp. ab1236 (a benanomicin producer). addition of sinefungin to strain e-40, pradimicin a aglycone-producing mutant or strain ab1236 inhibited the formation of 11-o-demethyl-7-methoxypradinone ii (11dm-7m-pn ii), resulting in the accumulation of 11-o-demethy ... | 1993 | 8478261 |
| numerical classification of sporoactinomycetes containing meso-diaminopimelic acid in the cell wall. | one hundred and thirty actinomycetes representing 19 genera and 50 species were compared in a numerical phenetic survey using 108 unit characters. data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using both the single and unweighted pair group average algorithms. cluster composition was barely affected by the statistics used or by test error, estimated at 2.1%. over 80% of the strains were assigned to 2 clusters containing ... | 1982 | 7077300 |