| a microbial etiology of acne? | the view is advanced that sebum as originally produced must contain materials, other than lipids, which may serve as a selective substrate for growth of bacteria and yeasts. growth of large numbers of p. acnes and p. granulosum in some follicles is considered to place those follicles at risk of undergoing pathological changes. deleterious products of bacterial growth could be not only lipase and free fatty acids, but also other enzymes as well as bacterial antigens and unspecified toxins or irri ... | 1976 | 138542 |
| acne from an immunological perspective. | patients with acne vulgaris, particularly those with severe inflammatory forms of the disease, are known to have high titers of serum antibodies, and intensified immediate hypersensitivity reactions to p. acnes antigens. the significance of this fact has not been clarified, but it is possible that antigen-antibody reactions involving p. acnes in the perifollicular dermis could intensify the inflammatory response in certain forms of acne. further studies utilizing newer, more sophisticated techni ... | 1976 | 138543 |
| antibiotic resistant acne. | our approach to a patient who fails to respond to antibiotics is as follows: first, take a careful history. look for use of cosmetics and topical corticosteroids, anticonvulsive agents and systemic corticosteroids. inquire about marked increases in emotional or psychological stresses accompanied by noticeable seborrhea. probe the patient about habits of leaning on or squeezing acne areas, and most importantly, inquire how often and in what manner the patient washes. in the physical examination, ... | 1976 | 138553 |
| predominant cultivable microbiota in periodontosis. | | 1977 | 138729 |
| acne fulminans: investigation of acute febrile ulcerative acne. | eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. this rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. at the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with ... | 1977 | 139850 |
| the inability of a bacterial lipase inhibitor to control acne vulgaris. | | 1977 | 142119 |
| [therapy of acne vulgaris using panoxyl]. | | 1977 | 143138 |
| an in vivo evaluation of the inflammatory effect of purified comedonal components in human skin. | | 1977 | 143497 |
| lymphocyte transformation in subjects with nodulo cystic acne. | patients with severe nodulo-cystic acne are known to have elevated serum antibody levels and increased immediate hypersensitivity reactions to propionibacterium acnes. this organism is the predominant bacterium in normal pilosebaceous follicles of human skin, and can be consistently isolated from pustular lesions in acne. previously it had been observed that delayed cutaneous hypersensitivity reactions to p. acnes were negative in patients with acne. the present study investigated the proliferat ... | 1977 | 143951 |
| [strains of propionibacterium acnes isolated from acne vulgaris (author's transl)]. | | 1977 | 146146 |
| local microwave hyperthermia (43 degrees c) and stimulation of the macrophage and t-lymphocyte systems in treatment of guerin epithelioma in rats. | | 1978 | 146340 |
| [blastogenic response in vitro of lymphocyte acne vulgaris]. | 32 patients with different degrees of acne and 10 healthy controls were studied. on every one of them the test for lymphocytic transformation was performed looking for the range of blastogenic response, using pha and ca. the positive findings with ca related to those obtained in normal subject would support the hypotesis that the cellular immunity as a response to ca antigens would be different in each patient according to the host local conditions. | 1977 | 147371 |
| acne. | | 1978 | 147953 |
| [polymorphous juvenile acne (author's transl)]. | many factors may be involved in the pathogenesis of acne, the most important of them lie in the sebaceous follicle, in disturbances of the cornification of the follicular channels and in the bacterial flora of the hair follicles. the latter consists of a yeast (pityrosporon ovale), coagulase-negative aerobic staphylococci and propionibacterium acnes. p. acnes is found in the depth of the follicle. it is of particular importance for the pathogenesis because it produces a lipase which releases fat ... | 1978 | 148004 |
| skin surface glycerol levels in acne vulgaris. | free glycerol would be expected from biochemical considerations to be an end product of lipolysis of sebum triglycerides. glycerol was measured in skin surface washings of acne vulgaris patients, in acne vulgaris patients treated for at least 3 mo with oral tetracycline and in control subjects. surface glycerol in untreated acne subjects was significantly less than that expected theoretically, whereas the amounts of such glycerol in treated acne patients and in control subjects closely approache ... | 1978 | 148480 |
| [porphyrinsynthesis of propionibacterium acnes in acne and seborrhea (author's transl)]. | the porphyrin productions of p a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, with respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. when separated by tlc the acne mat ... | 1978 | 148872 |
| complement activation by corynebacterium acnes. | | 1978 | 148901 |
| [effect of corynebacterium parvum on the immune response in guinea pigs. i. mode of enhancement of the anamnestic response and development of delayted hypersensitivity after treatment with corynebacterium parvum]. | the effect of corynebacterium parvum (c. parvuum) on the immune response of the guinea pig to ovalbumin varies with the protocol of immunization. the marked effect of c. parvum on the anamnestic response in the rabbit has been confirmed in the guinea pig when immunization is carried out intradermally with a mixture of c. parvum and ovalbumin. when c. parvum is given intravenously or subcutaneously or intradermally but separately from the antigen, this effect is not observed. whatever the route o ... | 1977 | 148948 |
| [effect of corynebacterium parvum on the immune response in guinea pigs. ii. passive transfer of enhanced anamnestic response and delayed hypersensitivity observed after treatment with corynebacterium parvum]. | after intradermal immunization with a mixture of corynebacterium parvum (c. parvum) and ovalbumin guinea pigs show a markedly increased anamnestic response to an intradermal booster of ovalbumin as compared to controls treated with ovalbumin only. at the same time a reaction of delayed type hypersensitivity is observed in the treated animals, but not in controls. the enhanced anamnestic response as well as the posivitive skin reaction were transferred to strain 2 histocompatible guinea pigs by p ... | 1977 | 148949 |
| [dandruff (pityriasis simplex capillitii)]. | in this review of new studies about dandruff, methods for clinical (subjective) evaluation and quantitative (objective) appraisal of dandruff are described. current concepts about histopathology, cytology, biochemistry and etiopathogenesis of this common condition of the scalp are detailed. | 1978 | 149094 |
| effect of propionibacterium acnes or bcg on enzyme activities in spleen lymphocytes of donryu strain rats. | immunopotentiated rats, which were injected with propionibacterium acnes or bcg, had the 50% survival twice as long as those in untreated controls after intravenous inoculation of sato lung carcinoma (slc) cells. the amount of labeled tumor cells in the lung of the adjuvant-treated rats decreased significantly in the first 20 hr after intravenous injection of 51cr-labeled tumor cells compared to that of control animals. the elevated activities of atpase and acid phosphatase in the whole nucleate ... | 1978 | 149684 |
| an analysis of conditions allowing corynebacterium parvum to cause either augmentation or inhibition of natural killer cell activity against tumor cells in mice. | we have analyzed the impact of in vivo administration of corynebacterium parvum on the mouse immune system against murine tumors, using the natural cytotoxic ability against tumors of normal mouse lymphoid cells as a baseline. a striking difference was found depending on the route of administration. intravenous inoculation of bacteria would result in a significant decrease or sometimes complete abolition of natural cytotoxicity toward tumor cells of the spleen cells of treated mice. on the other ... | 1978 | 149772 |
| cellular immunity to p. acnes in the normal population and patients with acne vulgaris. | patients with varying degrees of acne, acne-free adult controls and samples of cord blood were investigated for cell mediated immunity to p. acnes using a leukocyte migration inhibition test. despite the fact that the mean migration index tended to decrease with acne severity, only the patients with severe acne showed cell-mediated immunity. it is suggested that when cellular immunity arises it is a late event which may contribute to inflammation but is probably not a factor in its initiation. | 1978 | 150284 |
| on the propionibacteria in the pilosebaceous ducts of uninvolved skin of acne patients. | in 24 persons with a severe inflammatory acne and 48 control subjects, bacteria were sampled from the sebaceous gland exretory ducts with the glass sampling head method according to holland et al. after anaerobic culture bacterial counts were performed. the total numbers of p. acnes and the frequency of detection of p. granulosum were determined. the bacterial counts of p. acnes were almost idendical in the two collectives. p. granulosum was detected at a significantly higher frequence in the ac ... | 1978 | 150822 |
| dermatology: acne vulgaris. | | 1978 | 150871 |
| a clinical and bacteriological evaluation of the effect of sulphamethoxazole-trimethoprim in acne vulgaris, resistant to prior therapy with tetracyclines. | 42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase o ... | 1978 | 150980 |
| nutritional requirements of anaerobic coryneforms. | the nutritional requirements of three species of anaerobic coryneforms and their serotypes (propionibacterium acnes types i and ii, p. avidum types i and ii, and p. granulosum) were determined. strains of p. avidum would consistently grow to a transmittance of 1 to 3% at 560 nm in a basal salts medium supplemented with glucose, pantothenate, biotin, thiamine, and 12 amino acids (alanine, arginine, cysteine, glutamine, glycine, histidine, isoleucine, methionine, phenylalanine, serine, tyrosine, a ... | 1978 | 151095 |
| the chemoattractant properties of comedonal components. | acculation of clusters of polymorphonuclear leukocytes (pmn) along the periphery of the walls of comedones (predominantly of the closed variety), has been described as the first change marking the transition of quiescent, noninflamed lesions in acne, into inflammatory ones. the present study analyzed the chemoattractant properties of different comedonal components for human pmn in an effort to evaluate the potential significance of these substances in stimulating the chemotactic response of pmn ... | 1978 | 152335 |
| analysis of the water soluble extract of comedones. | the water soluble fraction of 713 open comedones, pooled from both the face and back of 47 subjects representing all grades of acne, were analyzed for total protein content, carbohydrate content, and for identification of specific proteins. in the water soluble fraction, the protein content represented 11.5%, and carbohydrate content 0.2% of the total comedonal crude weight. esterase and hyaluronidase activity was demonstrated. propionibacterium acnes antigenic material, serum albumin, and serum ... | 1978 | 152336 |
| hepatic arterial infusion of corynebacterium parvum and chemotherapy. | | 1978 | 152477 |
| prostaglandin-like substances in propionibacterium acnes. | | 1978 | 152714 |
| [the nitro-blue-tetrazolium test in acne vulgaris (9-12-77)]. | 41 patients with different av stages were studied with the quantitative nat test. in those cases where there was an inflammatory process (stages iii and iv) it was positive, while in was negative. the authors consider the relation between this test and the positive lymphoblastic transformation test to pa, which makes evident a coordinate action of the immune specific system and the granulocytic one. this facts show that av at the inflammatory stage is an immunologic systemic process and not only ... | 1977 | 152829 |
| complement activation in acne vulgaris: in vitro studies with propionibacterium acnes and propionibacterium granulosum. | to better define the role of bacteria in inflammatory acne vulgaris, we have investigated the ability of four strains of propionibacterium acnes and three strains of propionibacterium granulosum to activate complement. complement activation was assayed by incubating normal human serum with varying concentrations of each strain and measuring residual total hemolytic complement activity. when serum was tested unaltered, p. acnes strains were approximately threefold more potent than an equal weight ... | 1978 | 153333 |
| acne: current concepts. | | 1978 | 153517 |
| [in vitro blastogenic response of lymphocytes in acne vulgaris (ii) fusing as mitogens isolated from propionibacterium acnes]. | | 1977 | 153993 |
| the immunobiology of acne. a polyvalent proprionibacteria vaccine. | | 1979 | 154393 |
| [current theories on the pathomechanism of acne juvenilis]. | | 1979 | 155812 |
| [differentiation of various propionibacterium species from acne-vulgaris efflorescences]. | samples of pustules taken from 37 patients with acne (a. vulgaris, a. papulopustulosa, a. conglobata) were examined using different culture mediums for the growth of anaerobic to microaerophilic coryneforms. we identified 46 isolates of propionibacteria which were tested according to their morphological, biochemical, serological, and phagelysotopic reactions. three types of propionibacteria were found: p. acnes (33), p. granulosum (11) and p. avidum (2). nine samples showed p. acnes combined wit ... | 1979 | 156167 |
| the feasibility of replacing antibiotics by quaternary ammonium compounds in topical antimicrobial acne therapy. | determinations of the minimum inhibitory concentrations for various antimicrobial surfactants with reference to the bacteria p. acnes, p. granulosum, and st. epidermidis are reported. the results show that quaternary ammonium compounds can display minimum inhibitory concentrations corresponding to those of relevant antibiotics. with the especially effective substance fractionated dimethylcocobenzalkoniumchloride )arquad dmmcd-b), it could be further shown that with in vivo application in 70% iso ... | 1979 | 157107 |
| cytostatic effect on tumour cells induced in human monocytes by mediators from bcg-stimulated lymphocytes and mlc. | human monocytes activated by mediators (lymphokines) from bcg-stimulated, sensitized lymphocytes (from bcg-vaccinated donors) were cytostatic to a human cell line. mediators from allogeneic lymphocytes activated the cytostatic ability of monocytes to the same degree as mediators from autologous lymphocytes. mediators from bcg-stimulated lymphocytes from tuberculin-negative donors not vaccinated with bcg, activated the monocytes only to a small extent. culture of lymphocytes in a membrane chamber ... | 1979 | 158283 |
| complement activation in acne vulgaris: consumption of complement by comedones. | comedones, the contents of acne lesions, were shown to consume scomplement hemolytic activity in normal serum. this consumption was stimulated by the addition of serum from patients with inflammatory acne. absorption of acne serum with propionibacterium acnes cells removed all stimulating activity. immunoelectrophoretic analysis of serum incubated with comedones revealed the conversion of c3 and factor b in normal serum. the addition of acne serum resulted in cleavage of c4. in serum treated wit ... | 1979 | 159261 |
| bacterial flora of comedones. | open comedones from thirty-eight patients with acne vulgaris on the face or back were compared for microbial flora. a total of eighty-three comedones from the face and sixty-three from the upper back were individually processed for quantitative bacterial analysis. the greatest difference between the flora of comedones at these two sites was that 44.6% of comedones from the back (compared to 9.6% from the face) harboured no aerobic cocci. the decreased prevalence of staphylococci in the lesions f ... | 1979 | 160242 |
| extrusion of peritoneal catheter through abdominal incision: report of a rare complication of ventriculoperitoneal shunt. | a rare complication of a ventriculoperitoneal shunt is reported. the peritoneal catheter extruded through the well-healed abdominal incision. this is the first report of such an occurrence in an adult patient. | 1979 | 160511 |
| [antimicrobial effect of slaicylic acid on propionibacteria in the sebaceous infundibulum in the local treatment of acne vulgaris]. | | 1979 | 160687 |
| comparison of natural killer cells induced by kunjin virus and corynebacterium parvum with those occurring naturally in nude mice. | natural killer (nk) cells are rapidly elicited in the spleen and peritoneal cavity of mice inoculated intravenously or intraperitoneally with live kunjin virus, and more slowly in the peritoneal cavity of mice inoculated intraperitoneally with formalin-inactivated corynebacterium parvum. nk cells induced by either agent display cytotoxicity for a similar spectrum of syngeneic, allogeneic, and xenogeneic cultured cell lines. by contrast, the cells occurring naturally in the spleen of congenitally ... | 1979 | 160889 |
| acne. | the cause of acne is still obscure, but genetic predisposition, sebaceous overactivity, overgrowth of bacterial flora and exposure to comedogenic substances are all significant factors. acne lesions occur mainly in sebaceous follicles, which are characterized by deep follicular canals and large sebaceous glands. the associated seborrhea is not due to a circulatory excess of androgens but may be caused by a local amplification of androgenic activity. this, in turn, may be due to large numbers of ... | 1979 | 161830 |
| antibiotic susceptibility testing of anaerobic bacteria by the standardized disc diffusion method with special reference to bacteroides fragilis. | the susceptibility of 90 strains of bacteroides fragilis to 16 antibacterial drugs was determined by the agar plate dilution test and the disc diffusion test. good correlation of results was obtained with the two methods, and regression line analysis could be performed for beta-lactam antibiotics, erythromycin, tetracyclines, lincomycin and clindamycin. thus the standardized disc diffusion method can be used for susceptibility testing, but only a clear distinction between sensitive and resistant ... | 1975 | 167431 |
| influence of nitrate on fermentation pattern, molar growth yields and synthesis of cytochrome b in propionibacterium pentosaceum. | under anaerobic conditions, propionibacterium pentosaceum reduces nitrate to nitrite until nitrate is exhausted from the medium when nitrite is converted into n2 or n2o. in the presence of nitrate, fermentation patterns for lactate, glycerol and pyruvate were different from those obtained during anaerobic growth without an inorganic electron acceptor. in the presence of these substrates, a drastic decrease in propionate formation was observed, some pyruvate accumulated during growth with lactate ... | 1975 | 168306 |
| the electron transport system of the anaerobic propionibacterium shermanii: cytochrome and inhibitor studies. | 1. electron transport particles obtained from cell-free extracts of propionibacterium shermanii by centrifugation at 105000 times g for 3 hrs oxidized nadh, d,l-lactate, l-glycerol-3-phosphate and succinate with oxygen and, except for succinate, with fumarate, too. 2. spectral investigation of the electron transport particles revealed the presence of cytochromes b, d and o, and traces of cytochrome alpha1 and a c-type cytochrome. cytochrome b was reduced by succinate to about 50%, and by nadh, l ... | 1975 | 168827 |
| [first clinical trials of treatment of primary liver cancer with immunostimulating agents administered by systemic or intratumoral route]. | | 1975 | 170046 |
| histological and combined chemoimmunostimulation therapy studies against a murine leukemia. | a graffi murine leukemia was utilized as a model system to investigate the effect of chemoimmunostimulation therapy. subcutaneous inoculation of approximately 1.0 times 10(6) tumor cells resulted in a rapidly growing tumor at the site of inoculation and subsequent development of splenomegaly and lymphoadenopathy. all animals succumbed to the leukemia within 24 to 30 days. treatment of diseased animals with two courses of cytoxan over a 2-week period resulted in a remission period of approximatel ... | 1975 | 170212 |
| suppression of cell-mediated tumour immunity by corynebacterium parvum. | | 1975 | 170531 |
| isolation and characterization of a pyrophosphate-dependent phosphofructokinase from propionibacterium shermanii. | a pyrophosphate-dependent phosphofructokinase (pyrophosphate; d-fructose-6-phosphate-1-phosphotransferase) has been purified and characterized from extracts of propionibacterium shermanii. the enzyme catalyzes the transfer of phosphate from pyrophosphate to fructose 6-phosphate to yield fructose-1,6-p2 and phosphate. this unique enzymatic activity was observed initially in entamoeba histolytica (reeves, r.e., south, d.j., blytt, h.g., and warren, l. g. (1974) j. biol. chem. 249, 7734-7741). this ... | 1975 | 171261 |
| effect of pretreatment with mycobacterium bovis (strain bcg) and immune syphilitic serum on rabbit resistance to treponema pallidum. | stimulation of the rabbit reticuloendothelial system with viable mycobacterium bovis (strain bcg), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of treponema pallidum (virulent nichol's strain; mean infective doses less than 10). the simultaneous administration of immune syphilitic rabbit serum retarded the development of lesions, but this appeared to be due solely to the immune serum, suggesting no synergi ... | 1975 | 172450 |
| magnetic resonance studies of the proximity and spatial arrangement of propionyl coenzyme a and pyruvate on a biotin-metalloenzyme, transcarboxylase. | a spin-labeled ester of coa, r-coa (3-carboxy-2,2,5,5-tetramethyl-1-pyrolidinyl-1-oxy coa thioester), has been shown by competition studies using electron paramagnetic resonance (epr) and nuclear magnetic resonance (nmr) to bind specifically to the propionyl-coa binding sites of transcarboxylase. titrations indicate 0.7 +/- 0.2 binding site for r-coa per enzyme-bound biotin with a dissociation constant of 0.33 +/- 0.12 mm. propionyl-coa binds to this site with a 1.3-fold lower disonable agreemen ... | 1976 | 174714 |
| hydrosoluble immunostimulants of bacterial and synthetic origins. | the role of whole mycobacteria, mycobacterial cell walls and waxes d as immunostimulants was well established many years ago. more recently three different research groups have shown that hydrosoluble components from mycobacterial and other bacterial origins were as active as waxes d or cell walls and were free of many side-effects. studies concerning the relationship between structure and activity were achieved which led to the description of a small biologically active fragment and to a first ... | 1976 | 181265 |
| c. parvum suppression of rat tumours in athymic nude mice. | | 1976 | 184813 |
| immune response against hamster erythrocytes in the low-responder mouse strains. xi. strain difference in the effects of various microbial adjuvants. | enhancing and suppressing effects of microbial adjuvants were studied in female mice of the c3h/he, akr and sl strains. propionibacterium acnes, bordetella pertussis, bcg and yeast cell wall (ycw) were chosen as adjuvants. as antigens, we chose hamster erythrocytes (hrbc) which proved to be a weak antigen for mice. adjuvants were given on day --7, day 0 or day 3, and hrbc were injected on day 0. the results were as follows. 1) p. acnes facilitated igm and igg antibody production in akr mice and ... | 1976 | 186656 |
| immunochemotherapy with corynebacterium parvum in disseminated cancer. | | 1976 | 187100 |
| clinical immunoadjuvant studies with tilorone, deaa fluorene (rmi 11,002da), and corynebacterium parvum and some observations on the role of host resistance and herpes-like lesions in tumor growth. | | 1976 | 187101 |
| steady state and exchange kinetics of pyruvate, phosphate dikinase from propionibacterium shermanii. | evidence is presented based on requirements for exchange in the partial reactions, initial velocity and exchange kinetics and product inhibition, that the pyruvate, phosphate dikinase reaction of propionibacteria occurs by a nonclassical tri uni uni ping pong mechanism. the mechanism involves a pyrophosphoryl enzyme, a phosphoryl enzyme, and the free enzyme, and three functionally distinct and independent substrate sites. on the first site, there is pyrophosphorylation of the enzyme by atp with ... | 1976 | 187600 |
| modulation of mouse anti-trinitrophenyl plaque-forming cell affinity by adjuvants or lectins. | the efffects of several kinds of adjuvants or lectins, such as corynebacterium parvum, dextran, poly au, poly ic, dibutyryl camp, concanavalin a (con a), phytohemagglutinin (pha) and pokeweed mitogen (pwm) on anti-trinitrophenyl (tnp) direct plaque-forming cells (pfc) in the spleen of mice and the affinity of antibodies produced by these pfc were examined. the numbers of anti-tnp pfc in the spleens of mice which had been injected with c. parvum 7 days in advance were greater than those in contro ... | 1976 | 190432 |
| immunomodulation of host resistance to experimental viral infections in mice: effects of corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin. | resistance to a representative group of experimental virual infections in mice was significantly enhanced by nonspecific modulation of host defense mechanisms. corynebacterium acnes, corynebacterium parvum, and bacille calmette-guérin were effective in enhancing host resistance. animals treated seven to 10 days before inoculation of virus were protected against a lethal infection with herpesvirus hominis type 2, encephalomyocarditis virus, murine cytomegalovirus, or semliki forest virus. the pro ... | 1977 | 192811 |
| immunomodulator-induced resistance against herpes simplex virus. | | 1977 | 193122 |
| immunological mechanisms in metastatic spread and the antimetastatic effects of c. parvum. | the effects of the host's immune response on metastatic spread was investigated by observing the numbers of pulmonary metastases that developed from an s.c. implant of the lewis lung carcinoma in c57bl mice in which different cell populations had been suppressed. macrophage function was impaired by treatment with silica (si), cortisone acetate (ca), or trypan blue (tb). t-cell function was depressed by adult thymectomy and sublethal irradiation, or by treatment with antilymphocyte serum (als). m ... | 1977 | 193547 |
| protection against herpes simplex virus infection in mice by corynebacterium parvum. | corynebacterium parvum administered in mice prior to herpes simplex virus (hsv) infection significantly protected them against lethal encephalitis. this was seen both with a mouse strain highly susceptible to hsv and with one relatively resistant to hsv. mice immunosuppressed by cyclophosphamide and showing an increased mortality after hsv infection were also protected by c. parvum pretreatment. however, c. parvum given simultaneously with or after hsv infection did not exert a therapeutic effec ... | 1977 | 194841 |
| some reactions in which inorganic pyrophosphate replaces atp and serves as a source of energy. | | 1977 | 195842 |
| antibodies to bacterial and tumor-derived antigens in sera from normal guinea pigs. | antibodies that react with radiolabeled antigens derived from guinea pig line-10 tumor cells and mycobacterium bovis (bcg) were detected in sera from normal tumor-free strain-2 guinea pigs (ngps). binding by ngps to the two antigens was inhibited by extracts of either line-10 cells or bcg. binding by ngps to the line-10 antigen was inhibited by a number of other bacterial extracts. ngps was tested after absorption with a variety of cells including line-10, line-1, normal guinea pig spleen, norma ... | 1977 | 197169 |
| abrogation of antitumor effects of corynebacterium parvum and bcg by antimacrophage agents: brief communication. | the consistently demonstrable antitumor effect of corynebacterium parvum and bcg against a 7,12-dimethylbenz[a]anthracene-induced rat fibrosarcoma, growing either as a localized subcutaneous tumor or in ascites form, was abrogated by treatment of rats with antimacrophage agents such as silica or carrageenan. | 1977 | 200763 |
| enzymatic and hemolytic properties of propionibacterium acnes and related bacteria. | the production of chondroitin sulfatase, hyaluronidase, deoxyribonuclease, gelatinase, phosphatase, lecithinase, and hemolysins was examined in 95 strains of propionibacterium acnes and four related species of anaerobic, respectively, microaerophilic coryneform bacteria (p. avidum, p. lymphophilum, p. granulosum, and corynebacterium minutissimum). all enzymes could be demonstrated in at least one representative of the species tested. those propionibacterium species most frequently found in acne ... | 1977 | 201661 |
| possible involvement of natural killer cells in bone marrow graft rejection. | in the present study comparison between natural killer (nk) cells and cells responsible for rejection of bone marrow grafts was made. both cell populations were found to be inhibited by cyclophosphamide, silica, carrageenan, and c. parvum. the reactivity of both cell populations occurred late in life and was not expressed in infant mice. mice tolerant to bone marrow grafts and, therefore, accepting parental marrow transplants showed also decreased nk cell reactivities. these common features betw ... | 1977 | 203349 |
| detection of alcohols and volatile fatty acids by head-space gas chromatography in identification of anaerobic bacteria. | a head-space gas chromatographic technique for the analysis of volatile bacterial metabolites is described. bacteroides fragilis, clostridium perfringens, and propionibacterium acnes, cultured in a glucose-containing peptone yeast extract medium, were studied. the head-space technique was compared with the injection of the complete liquid culture medium, and solvent extracts thereof, into the gas chromatograph. volatile fatty acids could be detected by all three methods, whereas alcohols produce ... | 1978 | 203602 |
| mechanism of action of c. parvum on a solid, subcutaneous mouse tumour. | the effects of i.v. c. parvum on the growth of a.s.c. inoculum of the lewis lung carcinoma were studied in normal c57 b1 mice, and in those in which separate components of the immune response were impaired. c. parvum given either at the same time as tumour inoculation or when the carcinoma was 1 cm in diameter, and fully vascularised, reduced tumour growth. macrophages were impaired by silica (si), cortisone acetate (ca) or trypan blue (tb), and t cells by thymectomy and sublethal irradiation (t ... | 1977 | 204533 |
| combined use of local irradiation and corynebacterium parvum in the treatment of the murine line 1 lung carcinoma. | | 1978 | 204955 |
| binding of microorganisms to the macrophage plasma membrane; effects of enzymes and periodate. | the nature of the binding of c. parvum organisms to the surface of glass-adherent mouse peritoneal exudate cells in vitro was studied using pretreatment of the cells with various enzymes and periodate. trypsin, pronase, beta-galactosidase, phospholipases a, c and d and periodate all caused a decrease in binding to 40-60% of untreated control. neuraminidase led to a 30% increase in binding. the binding ability returned to normal after 1 h at 37 degrees in culture medium following exposure to all ... | 1978 | 205234 |
| enhanced resistance against junin virus infection induced by corynebacterium parvum. | the effects of intraperitoneal administration of corynebacterium parvum on the course of junin virus infection in mice were investigated. this treatment produced enhanced resistance to the virus infection, evidenced by an increase in both survival times and the proportion of survivors. the protective effect was dependent upon the dose of c. parvum, and 280 mug/g of body weight was found to be the optimal dose. in various experiments, about 80% of the infected animals receiving this dose survived ... | 1978 | 205508 |
| treatment of an intracerebral rat brain tumor with corynebacterium parvum and radiation. | rats bearing intracranial brain tumors were treated with single ip injections of the killed corynebacterium parvum, a single dose of x-rays, or a combination of both treatments. animals given injections of 2.6 mg c. parvum 12 days after implantation of the tumor had a median survival time (mst) of 50 days compared with an mst of 44 days for an untreated group. these animals given c. parvum had a 33% increased life-span (ils) that was significant at the p=0.05 level. although the mst of animals t ... | 1977 | 206836 |
| synergistic lysis of erythrocytes by propionibacterium acnes. | sheep and human erythrocytes, partially processed by staphylococcus aureus or clostridium perfringens, were susceptible to lysis in the presence of propionibacterium acnes. p. acnes liberated a lipase that was detected on tween 80 agar and also on phospholipase c-precipitated egg yolk agar. such a lipase might have contributed in the process of an intensified cellular lysis. similar reactions were attempted with lactobacillus acidophilus, known to possess a nondiffusible lipase, and failed to pr ... | 1978 | 212450 |
| protection of mice against viral infection by corynebacterium parvum and bordetella pertussis. | mice could be significantly protected against infection with herpes simplex virus (hsv) by i.p. or i.v. injection of killed corynebacterium parvum 7 days before infection. this protection was seen in inbred strains of mice with a different degree of sensitivity to hsv and after both i.p. and i.v. infection. resistant mice immunosuppressed by x-irradiation and showing an increased susceptibility to hsv could also be protected by a previous injection of c. parvum. elevated levels of interferon wer ... | 1978 | 212522 |
| defective in vitro lymphoproliferative responses to herpes simplex virus in patients with frequently recurring herpes infections during the disease-free interval. | | 1978 | 213220 |
| peritoneal macrophage activation indicated by enhanced chemiluminescence. | a number of studies have demonstrated the ability of various bacterial preparations, protozoa, and chemicals to activate macrophages and concomitantly to enhance host resistance to both tumors and infections. recently, viral infections have been shown to have a similar effect upon macrophage function. to better define the metabolic state of activated macrophages, we have evaluated the ability of peritoneal cells (pc) from vaccinia virus- or murine cytomegalovirus-infected or corynebacterium parv ... | 1978 | 213391 |
| effect of silver nitrate application on the conjunctival flora of the newborn: and the occurrence of clostridial conjunctivitis. | newborn conjunctival cultures were obtained from 35 babies prior to silver nitrate application and 48 hours later. on initial culture, 46 facultative bacteria and 27 anaerobes were recovered; 48 facultative and 18 anaerobes were recovered after 48 hours. haemophilus vaginalis, bacteroides species and anaerobic cocci decreased in numbers, whereas s. epidermidis, micrococcus and propionibacterium acnes increased during this time interval. clostridial species were isolated from two cases who develo ... | 1978 | 216788 |
| corynebacterium parvum as an adjuvant for trypanosoma cruzi epimastigote vaccines: a comparison with saponin and bordetella pertussis. | the effect was compared in cba mice of adding corynebacterium parvum, saponin, and bordetella pertussis to living or killed trypanosoma cruzi (y strain) epimastigote vaccines on the induction of protective immunity against subcutaneous (s.c.) challenge with blood trypomastigotes. the addition of c. parvum to a low dose of t. cruzi vaccine, which alone was non-protective, generated a greater degree of protection than did saponin or b. pertussis. c. parvum alone increased resistance to infection t ... | 1979 | 216967 |
| effects of corynebacterium parvum on murine myeloid leukaemia. | the effects of c. parvum on rfm/un myeloid leukaemia were studied. mice inoculated with 7.0 mg but not 0.7 mg c. parvum i.p. survived significantly longer than untreated leukaemic mice (p less than 0.001). administration of silica abrogated the effects of c. parvum, whilst polyvinyl pyridine-n-oxide prevented the inhibitory effects of silica. these studies demonstrate that a single large dose of c. parvum, either before or after leukaemic-cell passage, can significantly prolong the survival of r ... | 1978 | 217398 |
| prostaglandin-like substances in propionibacterium acnes ii. stimulatory effect on ovarian cyclic amp. | the prostaglandin-like substances (pls) from propionibacterium acnes increased the ovarian tissue levels of cyclic amp (camp) approximately 2-fold. the lipid material extracted from p. acnes thus behaved like pg's of the e-type, and since it is unlikely that other known stimulators of the ovarian camp system can be present in the bacterial lipid fraction, these experiments give further evidence in favour of the occurrence of pls in p. acnes. | 1979 | 217719 |
| low trimethoprim susceptibility of anaerobic bacteria due to insensitive dihydrofolate reductases. | all the 28 bacteroides fragilis strains investigated were susceptible to sulfamethoxazole (minimal inhibitory concentration < 16 mug/ml) and resistant to trimethoprim (tmp; minimal inhibitory concentration > 4 mug/ml). synergism between sulfamethoxazole and tmp was present in all strains at a ratio of 1:1. the few clostridia investigated proved more resistant to both compounds. dihydrofolate reductases from b. fragilis, c. perfringens, and some other anaerobic species were isolated. inhibition p ... | 1979 | 218496 |
| chemical properties of the principle in c. parvum that produces splenomegaly in mice. | suspensions of wellcome c. parvum strain 6134 produce splenomegaly in mice when injected i.p. in amounts as low as 20 microgram. this lymphoreticular stimulatory activity is extremely sensitive to cell breakage and is abolished by heating for 4 h at 100 degrees. periodate oxidation of the bacteria destroys their capacity to produce splenomegaly and abrogates the agglutination of intact c. parvum by con a. mild hcl hydrolysis also abolished the splenomegaly but phenol:chloroform:ether and chlorof ... | 1979 | 220183 |
| nicotinamide adenine dinucleotide-splitting enzyme in normal, elicited and activated peritoneal macrophages of the mouse. | | 1979 | 222905 |
| generation of cytotoxic lymphocytes against human tumor cells in vitro by various soluble microbial extracts. | | 1979 | 222929 |
| antitumor activity and lymphoreticular stimulation properties of fractions isolated from corynebacterium parvum. | | 1979 | 225023 |
| immunotherapy of lung cancer. ii. review of clinical trials in small cell carcinoma. | | 1979 | 226262 |
| nor-mdp, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques. | vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where freund's complete adjuvant has been employed. since this adjuvant is clinically unacceptable its replacement is a matter of urgency.in the present work a muramyldipeptide derivative (nor-mdp) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of macaca mulatta against plasmodium knowlesi, and saponin has proved to be effect ... | 1979 | 232428 |
| functional similarity and diversity in peritoneal macrophage populations induced in vivo by various stimuli. | | 1979 | 232817 |
| [effect of silica on the anti-tumour activity of "corynebacterium parvum" (author's transl)]. | silica, a specifically toxic substance for macrophages, has been used to study the role of these cells in the corynebacterium parvum-induced anti-tumour protection. in the two experimental tumours studied, silica, c. parvum and tumour cells were injected by the same route: the intravenous route in the case of lymphosarcoma in xvii mice and the intraperitoneal in that of mammary carcinoma in c3h mice. the inhibition of the anti-tumour effect of c. parvum by the administration of silica was more p ... | 1979 | 232975 |
| [hematological observations in patients following immunostimulation through intrapleural application of corynebacterium parvum]. | the ludwig lung cancer study group aims to investigate the role of immunotherapy as adjuvant treatment modality in operable non-small cell bronchial carcinoma. the participants are 12 european clinics and institutes. with a proven accrual of 350 patients per year the group offers a sharp tool in clinical oncology with regards to bronchial carcinoma. the accrual phase of the first trial was closed on february 2, 1979 with 475 patients, starting a new protocol on february 5, 1979. the ongoing rand ... | 1979 | 233458 |
| beta-galactosidase of propionibacterium shermanii. | ten strains of propionibacterium shermanii were tested for beta-galactosidase (beta-gal) activity. of these ten strains, five yielded enhanced enzyme activity when cell suspensions were treated with toluene-acetone; on solvent treatment, the remaining five lost a considerable portion of the activity found in whole-cell suspensions. by using a strain yielding decreased activity upon solvent treatment, explanations for the loss in activity were sought through assays for possible alternative beta-g ... | 1975 | 234159 |
| effect of corynebacterium acnes on interferon production in mouse peritoneal exudate cells. | corynebacterium acnes, an organism closely related to c. parvum, has been recognized to have a striking effect on the reticuloendothelial system, as well as on both humoral and cellular immunity. in mice previously exposed to c. acnes, serum interferon levels induced by injection of newcastle disease virus (ndv), chikungunya virus (cv), and polyinosinic-polycytidylic acid are suppressed. when peritoneal macrophages and lymphocytes from animals exposed to c. acnes were cultivated in vitro, their ... | 1975 | 234914 |
| analysis of bacterial biotin-proteins. | the biotin-protein populations in several bacterial strains were analyzed by solubilization of [3h]biotin-labeled cells with sodium dodecylsulfate followed by electrophoresis on polyacrylamide gels containing the detergent. a variety of patterns of biotin-labeled polypeptide chains was seen, ranging from a single biotin-protein in escherichia coli, corresponding to the biotin carboxyl carrier protein component of acetyl-coa carboxylase, to multiple species in enterobacter aerogenes, pseudomonas ... | 1975 | 235315 |
| succinyl-coa: propionate coa-transferase from propionibacterium shermanii. ec 2.8.3.6 succinyl-coa:propionate coa-transferase. | | 1975 | 235700 |
| [oral antigen treatment (oral vaccination) in acne diseases]. | | 1975 | 236624 |