| analysis of the internal nuclear matrix. oligomers of a 38 kd nucleolar polypeptide stabilized by disulfide bonds. | when rat liver nuclei are treated with the sulfhydryl cross-linking reagent sodium tetrathionate (natt) prior to nuclease treatment and extraction with 1.6 m nacl, residual nucleoli and an extensive non-chromatin intranuclear network remain associated with the nuclear envelope. subsequent treatment of this structure with 1 m nacl containing 20 mm dithiothreitol (dtt) solubilizes the intranuclear material, while the nuclear envelope remains structurally intact. we have isolated and partially char ... | 1986 | 3514251 |
| the effect of citric acid on growth of proteolytic strains of clostridium botulinum. | in strictly anaerobic conditions in a culture medium adjusted to ph 5.2 with hcl and incubated at 30 degrees c, inocula containing less than 10 vegetative bacteria of clostridium botulinum zk3 (type a) multiplied to give greater than 10(8) bacteria per ml in 3 d. growth from an inoculum of between 10 and 100 spores occurred after a delay of 10-20 weeks. citric acid concentrations of 10-50 mmol/l at ph 5.2 inhibited growth from both vegetative bacteria and spore inocula, a concentration of 50 mmo ... | 1986 | 3531139 |
| the effect of citric acid on growth of proteolytic strains of clostridium botulinum. | in strictly anaerobic conditions in a culture medium adjusted to ph 5.2 with hcl and incubated at 30 degrees c, inocula containing less than 10 vegetative bacteria of clostridium botulinum zk3 (type a) multiplied to give greater than 10(8) bacteria per ml in 3 d. growth from an inoculum of between 10 and 100 spores occurred after a delay of 10-20 weeks. citric acid concentrations of 10-50 mmol/l at ph 5.2 inhibited growth from both vegetative bacteria and spore inocula, a concentration of 50 mmo ... | 1986 | 3531139 |
| predation on rhodnius prolixus (hemiptera: reduviidae) by the spider theridion rufipes (araneida: theridiidae). | | 1987 | 3546692 |
| the early proximal tubule: a high-capacity delivery-responsive reabsorptive site. | the proximal convoluted tubule is responsible for reclaiming almost all of the filtered bicarbonate, glucose, and amino acids, as well as 40% or more of the filtered sodium, fluid, chloride, and phosphate. walker and co-workers demonstrated the importance of this nephron segment as a high-capacity transport site in the first mammalian micropuncture studies, and they suggested that the first portion of the proximal tubule played a particularly important role in the ability of the nephron to adapt ... | 1987 | 3551629 |
| [ultrastructure of rat oocytes during the induction of superovulation]. | the ultrastructure of ovocytes, fixed no later than 4-5 hours after the beginning of ovulation, the number of cells with the signs of organelle alterations is increased. this is presumably connected with a change in conditions of hormonal regulation of late stages of gametogenesis. | 1986 | 3564153 |
| changes in physiological properties of rabbit oviduct by ovarian steroids. | effects of estrogen and progesterone on electrical and mechanical properties of longitudinal smooth muscle cells of the rabbit fallopian tubes were investigated using microelectrode and isometric tension recording methods. in tissues from the estrogen-treated rabbits, there was a decrease in frequency of spontaneous contractions, whereas an increase was seen in tissues from the progesterone-treated rabbits. the membrane potential of smooth muscle cells of the fallopian tube was -58.5 mv. followi ... | 1987 | 3591978 |
| rate responsive pacing compromise: response time vs. heart rat variation. | | 1987 | 3607189 |
| a rapid and simple method for determining catecholamines in human plasma and cerebrospinal fluid using high-performance liquid chromatography with electrochemical detection. | a procedure for assaying free norepinephrine, epinephrine, and dopamine in plasma and cerebrospinal fluid (csf) is described. the method involves adsorption of the catechols onto alumina, desorption, and injection into a reverse-phase ion-pairing liquid chromatography system equipped with a coulometric detector. optimization of chromatographic conditions with regard to detector performance and keeping to procedures and precautions described make the method applicable both to neurochemical resear ... | 1986 | 3609853 |
| effects of dietary sugar and of dietary fat on food intake and body fat content in rats. | the long term ingestion of a sugar-rich diet (low fat) caused severe obesity in adult rats. in a separate experiment, the habitual consumption of a fat-rich diet (40% kcal from fat) also caused severe obesity. severe obesity developed in both groups of animals even though they did not overeat. voluntary food intake for the sugar-fed rats averaged 28,314 +/- 756 calories/rat per 55 wks which was similar to the value of 28,884 +/- 953 calories/rat per 55 wks for the fat-fed rats. however, both val ... | 1987 | 3623194 |
| carcinogenicity of antitumor cis-platinum(ii) coordination complexes in the mouse and rat. | | 1979 | 427778 |
| evidence for a class 4 effect of cibenzoline "in vivo". | in anesthetized dogs, it has already been shown that cibenzoline (4 mg/kg i.v.) possesses class 1 anti-arrhythmic properties. in this work, the cardiac electrophysiologic effects of cibenzoline (1 mg/kg i.v.) were studied before and after propranolol (0.2 mg/kg i.v.) treatment. cibenzoline caused a slight tachycardia, a reduction of conduction velocity in the his-purkinje system and in the ventricle, but no significant effects in the atria and the atrioventricular node were detected. on the cont ... | 1987 | 3632139 |
| induction of a rapidly responsive hepatic gene product by thyroid hormone requires ongoing protein synthesis. | the regulation of a gene, designated spot 14, which is rapidly induced in rat liver in response to 3,5,3'-triiodo-l-thyronine (t3) was studied as a model for exploring the molecular basis of thyroid hormone action. the time course of induction of the nuclear precursor to spot 14 mrna after intramuscular injection of t3 displayed a very short lag period of between 10 and 20 min. the rapidity of this effect suggests that the induction in gene expression occurs as a primary response to the hormone- ... | 1987 | 3648478 |
| plasma concentration of local anaesthetic agents in regard to absorption, distribution and elimination, with special reference to bupivacaine. | absorption from the injection site, tissue distribution, metabolism and urinary excretion are the factors determining the plasma concentration of local anaesthetic agents. other factors such as physico-chemical properties of these drugs may have important influences on these processes. an example of this is the difference in tissue distribution and plasma/erythrocyte ratio as well as an increase in plasma concentration of bupivacaine seen in acidosis. the importance for the plasma concentration, ... | 1975 | 238555 |
| gliosarcoma with chromosome abnormalities in a neonate exposed to heptachlor. | a neonate with a cerebral gliosarcoma was found to have chromosome abnormalities in tissue culture of the tumor, but normal karyotyping of peripheral blood. similarities to and differences from chromosome abnormalities found in other human gliomas are noted. unusual exposure of the child to heptachlor during prenatal development and the neonatal period suggests the need for further studies on the role of toxins in oncogenesis. | 1987 | 3683793 |
| [in vitro growth of lingual epithelial basal cells as affected by an extract of the nodose ganglion]. | nodose ganglion extract has a stimulating effect on the in vitro proliferation of tongue epithelium basal cells. neurotrophic control of these target cells can be realized by mitogen-like chemical factors which are probably synthesized in sensory neurons, secreted from afferent nerve terminals and stimulate the proliferation of competent cells. | 1986 | 3697497 |
| metabolism of magnolol from magnoliae cortex. ii. absorption, metabolism and excretion of [ring-14c]magnolol in rats. | | 1986 | 3698126 |
| anaphylactic release of a basophil kallikrein-like activity. i. purification and characterization. | these studies describe the ige-mediated relase of a basophil kallikrein-like enzyme that is an arginine esterase and is inhibited by plasma, diisopropylphosphofluoridate, and trasylol. the substrate specificity for the synthetic amino acid ester substrates p-toluenesulfonyl-l-arginien methyl ester, benzoyl-arginine methyl ester, and acetyl-tyrosine methyl ester is similar for the basophil enzyme and plasma kallikrein. the interaction of arginine esterase-active fractions from ion-exchange (deae- ... | 1979 | 37257 |
| serological examinations for antibodies against legionella species in dental personnel. | serum samples from 107 dentists, dental assistants, and dental technicians were examined with an indirect immunofluorescence test for antibodies to legionella pneumophila sg1-sg6, l. micdadei, l. bozemanii, l. dumoffii, l. gormanii, l. jordanis, and l. longbeachae sg1 + 2. thirty-six (34%) employees from dental personnel from 13 practices showed a positive reaction for antibodies to legionella pneumophila. only five samples (5%) from a control group (non-medical workers) were positive. of the 36 ... | 1988 | 3170906 |
| amplification and rearrangement of dna sequences during the evolutionary divergence of t haplotypes and wild-type forms of mouse chromosome 17. | | 1986 | 3731843 |
| the shape of renal vasa recta capillaries and its effect on calculation of single capillary blood flow. | previous studies of the renal papilla of the rat have suggested that the vasa recta capillaries can be well approximated by elliptical cylinders (c. holliger, k. v. lemley, s. l. schmitt, f. c. thomas, c. r. robertson, and r. l. jamison, 1983, circ. res., 53, 401-413). this hypothesis was validated in a morphological study employing several methods of specimen fixation and preparation. papillas of young (body wt = 90 g) wistar rats were fixed and subsequently examined by light and electron micro ... | 1986 | 3736443 |
| high oxygen requirements of dyskinetic cardiac muscle. | this study assesses the regional oxygen requirements of muscle segments that are beating and working, beating and empty, arrested and decompressed, and nonischemic that move dyskinetically. regional oxygen demands were evaluated by producing a dyskinetic segment by infusing regional cardioplegic solution through a left anterior descending coronary artery catheter with and without extracorporeal circulation. the results show that the o2 demands of the perfused dyskinetic cardiac muscle segment (4 ... | 1986 | 3747582 |
| the inability of a south african babesia bovis vaccine strain to infect boophilus microplus. | a strain of babesia bovis that had been attenuated by rapid syringe passage through a series of 23 splenectomized calves was unable to infect its vector boophilus microplus. an attempt to transmit the attenuated australian babesia bigemina g strain with a south african strain of b. microplus was likewise unsuccessful. the epidemiological implication of these observations in terms of babesiosis control is discussed. | 1986 | 3763166 |
| in vitro acetylcholine synthesis and oxidative metabolism during development of normal and brindled mouse brain. | during early development normal and brindled mouse brain use 3-hydroxy-butyrate preferentially to glucose as a source for biosynthetic carbon units. on postnatal days 5-60, co2 and acetylcholine production from 3-hydroxybutyrate decrease while that from glucose increases. glucose metabolism exceeds that of 3-hydroxybutyrate after weaning (day 21). these findings indicate that the immature brain uses 3-hydroxybutyrate to support effectively oxidative metabolism and acetylcholine synthesis. defici ... | 1986 | 3768723 |
| bioassay for sf 86-327, a new antifungal agent. | a bioassay with trichophyton mentagrophytes is described for sf 86-327, an allylamine antifungal agent. sf 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. the peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. drug accumulation occurred with prolonged therapy. | 1986 | 3789699 |
| treatment of idiopathic west and lennox-gastaut syndromes by intravenous administration of human polyvalent immunoglobulins. | a total of 7 patients (3-21 years old) suffering from an intractable "primary" lennox-gastaut syndrome (lgs) were treated with i.v. high doses of polyvalent human immunoglobulins. of these patients 6 improved following such treatment with a decrease in fits and an improvement in the eeg. hypotheses about the contribution of the treatment and immunopathological factors in some cases of idiopathic lgs are discussed. | 1986 | 3792407 |
| serotypes of ureaplasma urealyticum in spontaneous abortion. | ureaplasma urealyticum was isolated from the tissues of 63 of 264 (24%) spontaneous abortions obtained by unaided vaginal delivery or by suction/sharp curettage and from 22 of 259 (8%) therapeutic abortions obtained by suction curettage. the isolates were serotyped by a modified indirect colony epifluorescence test. no differences in the incidence of specificities in the test and control groups were apparent, although statistical analysis of the data remains to be performed. nor, based upon prel ... | 1986 | 3797325 |
| response of dogs to challenge with ancylostoma ceylanicum during the tenure of a primary hookworm infection. | a model of human hookworm infection has been developed which shows that dogs currently infected with small numbers of hookworms are considerably resistant to a challenge infection with a large inoculum of infective larvae. two groups of dogs were infected with 500 larvae and four weeks after infection one group together with a previously uninfected control group were infected with 5,000 larvae and followed for six weeks. when compared with the secondary infection control dogs, faecal egg excreti ... | 1986 | 3798534 |
| [setting standards for reflected laser radiation]. | | 1986 | 3798876 |
| plaque color method for rapid isolation of novel reca mutants of escherichia coli k-12: new classes of protease-constitutive reca mutants. | as a prerequisite to mutational analysis of functional sites on the reca protein of escherichia coli, a method was developed for rapid isolation of reca mutants with altered reca protease function. the method involves plating mutagenized lambda reca+ ci ind on strains deleted for reca and containing, as indicators of reca protease activity, mu d(ap lac) fusions in reca-inducible genes. the lambda reca phages were recognized by their altered plaque colors, and the reca protease activity of the la ... | 1985 | 3160686 |
| coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. | to investigate disturbances in the coronary circulation and myocardial metabolism during septic shock, we examined coronary sinus blood flow and myocardial substrate extraction in 40 patients with septic shock and 13 control patients. patients with coronary artery disease were excluded from this study. the global hemodynamic pattern of the septic patients was characterized by a lower stroke volume, despite an elevated cardiac index. coronary sinus blood flow was high (187 +/- 47 vs 130 +/- 21 ml ... | 1987 | 3815765 |
| an evaluation of automaticity and triggered activity in the canine heart one to four days after myocardial infarction. | both abnormal automaticity and triggered activity induced by delayed afterdepolarizations have been proposed as the primary mechanism for ventricular tachycardia (vt) occurring in dogs 24 hr after ligation of the left anterior descending coronary artery. because of this controversy, we studied the effects of ventricular pacing and therapeutic concentrations of lidocaine and ethmozin on sustained rhythmic activity of isolated subendocardial preparations excised from the infarct, and on vt in cons ... | 1985 | 3888438 |
| some cellular and molecular aspects of the vascular complications of diabetes. | | 1985 | 3911057 |
| anisodamine effects on functional and morphologic changes of platelets in endotoxinemic rabbits. | | 1985 | 3922686 |
| increased udp-glucuronyltransferase in putative preneoplastic foci of human liver after long-term use of oral contraceptives. | previous research by the authors had suggested that uridine-diphosphate-glucuronyl-transferase (udp-gt) is a useful preneoplastic marker in chemical carcinogenesis. recently the authors report that they found typical clear cell foci in a macroscopically normal liver surrounding focal nodular hyperplasia with a 6 cm diameter in a 27-year old woman who had been using oral contraceptives (ocs) containing ethinyl-estradiol and lynestrenol for 9 years. these foci were further characterized by a red ... | 1985 | 3925352 |
| purification of arachidonic acid metabolites from cell cultures by octadecyl reversed phase cartridges. | the use of rat basophilic leukemia (rbl-1) cell-line as a biosynthetic source of arachidonic acid metabolites has been previously described. we have developed a rapid and effective procedure for the extraction of lipoxygenase and cyclooxygenase products. the cells grown in spinner cultures were harvested and washed in phosphate buffer and stimulated by calcium ionophore a23187. the ethanolic extract of the cells was dried, dissolved in 20% methanol acidified with acetic acid and applied to octad ... | 1985 | 3930318 |
| purification of arachidonic acid metabolites from cell cultures by octadecyl reversed phase cartridges. | the use of rat basophilic leukemia (rbl-1) cell-line as a biosynthetic source of arachidonic acid metabolites has been previously described. we have developed a rapid and effective procedure for the extraction of lipoxygenase and cyclooxygenase products. the cells grown in spinner cultures were harvested and washed in phosphate buffer and stimulated by calcium ionophore a23187. the ethanolic extract of the cells was dried, dissolved in 20% methanol acidified with acetic acid and applied to octad ... | 1985 | 3930318 |
| aortic endothelial and smooth muscle cell interactions in culture. | the effect of conditioned media on cell growth was studied in pig aortic smooth muscle cell conditioned medium on pig or bovine aortic endothelial cells and pig or bovine endothelial cells conditioned medium on pig aortic smooth muscle cell proliferation. co-culturing experiments were also done in the same combinations. cell proliferation was measured in both systems by 3h-thymidine incorporation autoradiography. in intraspecies combinations the media conditioned by confluent pig-aortic endothel ... | 1986 | 3111182 |
| acrosomal proteinase activity of human spermatozoa and relation of results to semen quality. | an assay for measuring the acrosomal proteinase activity of human spermatozoa with the use of a microscope slide coated with a thin layer of gelatin as a protein substrate was developed and applied to study the semen of 82 males from infertile couples and 15 normal donors. acrosomal protease activity is indicated by a clear area of proteolyzed gelatin (halo) about the sperm head. probit analysis revealed two populations divided at a halo diameter of 14 microns. the patient samples were grouped a ... | 1988 | 3068243 |
| histochemical identification of guinea-pig macrophages by monoclonal antibody mr-1. | a monoclonal antibody is described which reacts with monocytes and macrophages of the guinea-pig. the antibody recognizes a cytoplasmic component in the majority of tissue macrophages, as detected by histochemical analysis. it reacts positively with all macrophages in lymphoid organs, including tingible body macrophages. in addition it recognizes the cells of von kupffer in the liver, and macrophages in bone marrow and peritoneal cavity. in comparison to other monoclonal antibodies that have bee ... | 1988 | 3065217 |
| isolation of a cdna clone for the dihydrolipoamide acetyltransferase component of the human liver pyruvate dehydrogenase complex. | dihydrolipoamide acetyltransferase (e2) forms the structural core of pyruvate dehydrogenase complex. a cdna clone (lambda e2-1) for mammalian e2 was identified from a human liver lambda gt11 library using anti-e2 serum. affinity-selected antibodies using the fusion protein from lambda e2-1 immuno-reacted specifically with e2 of purified pyruvate dehydrogenase complex on immuno-blot analysis. the cdna insert was approximately 2.3 kb in length with an internal ecor1 site generating 1.4 and 0.9 kb ... | 1987 | 3036145 |
| utilization of glutamate accumulating bacterial cells for production of ribonucleotides. | corynebacterium glutamicum cells are industrially used for glutamate production. however, the waste that contains microbial cells, cellular debris, residual sugars, ammonia and metabolites seriously pollutes the environment. the cells are recovered and utilized for ribonucleotide production so that the pollution caused by the cells is eliminated. nucleic acid is extracted from the cells and is hydrolyzed with nuclease p1 from penicillium citrinum. the hydrolysate is fractionated with dowex-50 an ... | 1985 | 3033725 |
| temperature modulates ethanol sensitivity in mice: generality across strain and sex. | findings in our laboratory indicate that body temperature alters ethanol potency as measured by sleep-time, wake-up brain ethanol concentration and mortality in male c57bl/6j mice. the current studies tested the generality of these results. experiment one tested age-matched, drug-naive, male c57bl/6s and balb/cs mice. experiment two tested age-matched, drug-naive, male and female c57bl/6j mice. each mouse was injected ip with 3.6 g/kg ethanol (20% w/v). after losing its righting reflex, the mous ... | 1985 | 4015848 |
| sensitivity of ortho- and paramyxovirus replication to human interferon alpha. | replication of the influenza virus strains influenza ao/wsn (h0n1), fowl plague (hav1n1) and b-lee/40 (atcc) and the paramyxovirus, new castle disease virus (victoria) are highly sensitive to human interferon type alpha in madin darby bovine kidney cells. pretreatment of cells with human interferon type alpha resulted in protection of the cells against viral cytopathic effect. the inhibition of the orthomyxovirus strains used in this study and new castle disease virus replication is mediated by ... | 1985 | 4069110 |
| the coelomic elements of sea urchins (strongylocentrotus and centrostephanus). vi. cellulose-acetate membrane electrophoresis. | | 1970 | 4099938 |
| the eeg during and after elective circulatory arrest in human subjects. | | 1971 | 4103541 |
| analysis of antibody populations to oligo-alanine determinants. 3. the participation of subclasses igg1 in the antibody response in inbred mice. | | 1973 | 4126776 |
| proceedings: control by feeding habits of the induction of hepatic dna synthesis by alpha-hexachlorocyclohexane. | | 1974 | 4135779 |
| analysis of the c-value paradox by molecular hybridization. | poly(a)-containing rna was isolated from ovaries of xenopus laevis laevis and triturus cristatus carnifex and used as a template for the synthesis of radioactive complementary dna with rna-dependent dna polymerase. when annealed with an excess of homologous dna, the complementary dna is rendered double-stranded with kinetics that suggest that the coding sequences are single-copy in both these organisms. in triturus, these sequences are distinct from the majority of the genome, which consists of ... | 1974 | 4139720 |
| a new technique for functional visual deprivation. | | 1974 | 4140078 |
| patterns of transcription in bacillus subtilis during sporulation. | | 1973 | 4148782 |
| [the influence of sodium chloride and carbon dioxide on the growth of neisseria meningitidis on nutrient agar (author's transl)]. | | 1974 | 4152350 |
| proceedings: uptake of neurotransmitters into subcellular particles of the caudate nucleus. | | 1974 | 4152365 |
| a naturally occurring fragment related to the heavy chains of immunoglobulin g in normal human urine. | | 1966 | 4164143 |
| [immunochemical studies on the antigen structure of leptospira]. | | 1966 | 4168211 |
| neonatal thyroid disease: differential expression in three successive offspring. | neonatal thyroid disease, manifested as either hyperthyroidism or hypothyroidism, has been described in the offspring of women with autoimmune thyroid disorders. we report clinical and laboratory observations in a mother with autoimmune thyroiditis who gave birth to three children with different forms of thyroid dysfunction. the first child was clinically normal, the second child had transient neonatal hyperthyroidism, and the third child had neonatal hypothyroidism. after the birth of the secon ... | 1988 | 2895120 |
| oxygen consumption of the germinal epithelium in psoriatic human skin as measured by the cartesian diver micro-gasometer. | | 1968 | 4185292 |
| [masugi hetero-immune nephritis in rats. 3. histological and ultrastructural study. (attempt of comparison with protein data)]. | | 1969 | 4187677 |
| asymmetric transcription of spp1 in vivo. | | 1973 | 4200375 |
| thyrotropin releasing hormone: enhancement of dopa activity in thyroidectomized rats. | | 1974 | 4207315 |
| identification of d-erythro-dihydroneopterin triphosphate, the first product of pteridine biosynthesis in comamonas sp. (atcc 11299a). | | 1974 | 4213160 |
| [susceptibility of various bacteria isolated from patients with infections of the urinary tract against carbenicillin]. | | 1973 | 4219780 |
| delayed hypersensitivity to trichinella spiralis. 3. effect of repeated sensitizations in donors and recipients. | | 1970 | 4246565 |
| biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. | | 1970 | 4246573 |
| [distribution of diisopropyl-phosphore-fluoridate (dfp) between isolated atrial tissue and circulating oxygenated blood in guinea pigs]. | | 1970 | 4249228 |
| [submicroscopic structure of l-forms of group a streptococci prepared by means of penicillin and bacitracin]. | | 1971 | 4252073 |
| effects of azathioprine therapy on bone marrow-dependent and thymus-dependent cells in man. | | 1973 | 4271771 |
| molecular weight studies of canine cardiac myosins. | | 1974 | 4277579 |
| molecular weight studies of canine cardiac myosins. | | 1974 | 4277579 |
| influence of protein and calorie deficiencies in the rat on the energy-transfer reactions of the striated muscle. | | 1964 | 4284462 |
| experimental endocarditis. endocrine factors in valve lesions on av shunt rats. | | 1966 | 4287171 |
| effect of polynucleotides on aminoacyl transfer ribonucleic acid synthetases. 3. inhibition of glutamyl transfer ribonucleic acid synthetase by natural polynucleotides. | | 1968 | 4299520 |
| activation of adenyl cyclase by glucagon in cat and human heart. | | 1969 | 4303624 |
| activation of adenyl cyclase by glucagon in cat and human heart. | | 1969 | 4303624 |
| adenyl cyclase in human platelets: activity and responsiveness. | a clinical study was conducted whereby the activity of adenyl cyclase in the human platelet was demonstrated. the study showed that this activity can be stimulated and inhibited in vitro. platelets were isolated from normal donors. the laboratory procedures involved in the study are described in detail. it seems that many of the biologic processes which occur in the human platelet are dependent on the breakdown of atp (adenosine-tri-phosphate) to, among other substances, amp (adenosine-3',5' ... | 1969 | 4306955 |
| [suppression of the pontogeniculo-occipital points of sleep by lesion or injection in situ of 6-hydroxydopamine in the tegmentum of the pons]. | | 1970 | 4332427 |
| biosynthesis of n-acetylneuraminic acid in morris hepatomas. | | 1973 | 4347091 |
| [biochemical studies on human salivary proteins. xi. effect of saliva-parotin-a on phosphatase activities]. | | 1972 | 4347599 |
| linear electric field-induced shifts in electron paramagnetic resonance: a new method for study of the ligands of cytochrome p-450. | the linear electric field shift in paramagnetic resonance has, for the first time, been observed in frozen solutions. the magnitude of the shift parameters, measured at g(max) of the electron paramagnetic resonance absorption envelope, has been used to characterize lowspin ferric heme mercaptide complexes where the nonmercaptide ligand was varied. the magnitude of the shift provides a measure of the difference between the crystal field contribution of the mercaptide and nonmercaptide ligands. in ... | 1973 | 4355378 |
| protein kinases in testes of adult and prepuberal rats. | | 1974 | 4369082 |
| continuous lymphoid cell lines with characteristics of b cells (bone-marrow-derived), lacking the epstein-barr virus genome and derived from three human lymphomas. | three exceptional cell lines have been tested for the presence of the epstein-barr virus genome by nucleic acid hybridization (complementary rna.dna) and epstein-barr virus-determined nuclear antigen tests. two lines were derived from swedish lymphoma cases and one from an african burkitt-like lymphoma biopsy that was negative for epstein-barr virus dna and the virus-determined nuclear antigen. all three lines apparently lacked the viral genome. two of the three lines clearly had characteristics ... | 1974 | 4369887 |
| [pulmonary radiation exposure following endolymphatic therapy. 3. dosimetric distribution study in rabbit lung following endolymphatic therapy]. | | 1973 | 4375317 |
| [comparative characteristics of the functional activity of the pituitary-adrenal system in hibernating animals]. | | 1974 | 4375370 |
| the effect of temperature and some antagonistic drugs on anaphylactic shock in the rat. | | 1968 | 4384123 |
| concerning the histamine receptor (h1). | | 1969 | 4390839 |
| concerning the histamine receptor (h1). | | 1969 | 4390839 |
| ecological studies of japanese encephalitis virus in mie prefecture. i. viremia in natully infected pigs and viremic mosquitoes. | | 1969 | 4390860 |
| an unusual inhibitory effect of histamine: suppression of atropine-resistant tetanic spasms after mepyramine block of histamine contractions. | | 1969 | 4390876 |
| immunocytochemical studies on thyroid parafollicular cells in postnatal development of the rat. | studies were performed on wistar strain rats aged 1-720 days. immunocytochemical reactions were used to detect calcitonin, somatostatin, calcitonin gene-related peptide (cgrp), cholecystokinin, serotonin, neuron-specific enolase (nse), secretory protein-i, chromogranin and ca-binding protein. in the parafollicular cells of the rat, the presence of calcitonin, somatostatin, cgrp, nse and secretory protein-i could be demonstrated. the number of parafollicular cells increased with the age of animal ... | 1987 | 2893508 |
| unusual dna sequences located within the promoter region and the first intron of the chicken pro-alpha 1(i) collagen gene. | genomic clones corresponding to the amino-terminal propeptide and 5'-flanking sequences of the chicken pro-alpha 1(i) collagen gene were isolated as a first step in the identification of dna sequences important for transcriptional regulation of the pro-alpha 1(i) collagen gene. due to the failure to identify positive clones in either primary or amplified genomic libraries, a 5.1-kilobase pair stui genomic fragment identified by southern blotting was enriched by sucrose gradient fractionation of ... | 1987 | 2820966 |
| signet ring cell lymphoma of t cell type. | a rare variant of non-hodgkin's lymphoma, signet ring lymphoma of t cell phenotype (only the fourth to be reported) in a 75 year old man was studied by light microscopy, immunohistochemistry, electron microscopy and gene rearrangement studies. ultrastructurally, a wider spectrum of cell size and nuclear shape was observed in this case than in the previously recorded cases. the morphology of the signet ring vacuoles was identical to that found in the commoner b cell signet ring lymphoma of clear ... | 1989 | 2784803 |
| afferent renal nerve effects on plasma vasopressin and oxytocin in conscious rats. | experiments were done in conscious, unrestrained, baroreceptor-intact rats to investigate the effects of afferent renal nerve (arn) stimulation on circulating levels of arginine vasopressin (avp) and oxytocin (oxy). electrical stimulation of arn elicited a rise in arterial pressure (ap) of 12 +/- 2 mmhg and no significant change in heart rate (hr). plasma concentrations of avp and oxy measured by radioimmunoassay were significantly increased immediately after the stimulation period. avp increase ... | 1989 | 2735450 |
| altman tapped to be new hcfa administrator. | | 1989 | 2731914 |
| [participation of the olfactory system in the regulation of food intake]. | evoked potentials in the olfactory bulb (ob), lateral hypothalamus (hl) and rostral portion of the nucleus of the tractus solitarius (nts), were recorded after cervical vagus nerve stimulation. the slow component in the ob only was recorded in the periglomerular layer. electrolytic lesion of the nts, abolished the evoked potentials in the ob by vagus nerve stimulation. the results of the present experiments indicate that the pathway from the vagus nerve to ob go into the nts but probably not int ... | 1989 | 2633947 |
| [coagulation and fibrinolysis associated with contact phase in plasma with high molecular weight kininogen deficiency]. | congenital deficiency of high molecular weight kininogen (hmwk), first reported by saito et al. in 1975, is a rare disorder with homozygous defect of hmwk and only 14 cases have been reported so far. prolonged partial thromboplastin time and depressed intrinsic fibrinolytic activity in plasma interacted with negatively charged surface were characterized in these patients without any bleeding problem. on the other hand, patients associated with hemorrhagic disorder, such as haemophiliacs, showed ... | 1989 | 2593236 |
| early increase in diadenosine tetraphosphate in regenerating rat liver. | diadenosine tetraphosphate (ap4a), a candidate for a signal molecule in the induction of dna synthesis, was measured in regenerating livers of young adult rats at 12 and 24 h and of older rats at 24 h after partial hepatectomy. datp and dttp levels, which indicate the degree of proliferation in the livers, were determined by high-performance liquid chromatography and an enzymatic method, respectively. the ap4a levels were increased in the beginning of dna synthesis. in young rats the levels were ... | 1988 | 3360062 |
| the effect of vanadium on lung collagen content and composition in two successive generations of rats. | lung collagen content in rats continuously exposed for two generations to 20 ppm vanadium as sodium metavanadate drinking solution was quantified by measurement of hydroxyproline in hydrolysates of whole lungs. the content of soluble and insoluble collagen isolated from the lungs of the same treated rats was also quantified by the same means. it was found that the content and composition of lung collagen for both f1 term fetuses and 21-day-old f1 pups of the treated group did not differ from the ... | 1988 | 3376147 |
| assay of cholesterol 7 alpha-hydroxylase activity in rat hepatocytes in primary monolayer culture. | a sensitive and precise method is described to assay cholesterol 7 alpha-hydroxylase activity in homogenates of rat hepatocytes cultured in monolayers for up to 76 h. the assay is based on measurement of the amount of radioactive cholesterol converted into 7 alpha-[14c]-hydroxycholesterol. since no subcellular fractionation was applied to measure enzyme activity, this method is rapid and can be performed with cell protein, corresponding to as little as 1 to 2 million hepatocytes. optimal assay c ... | 1988 | 3407912 |
| polymerization of vertebrate non-muscle and smooth muscle myosins. | we investigated how light chain phosphorylation controls the stability of filaments of vertebrate non-muscle myosins (from bovine thymocytes and chicken intestine epithelial brush border cells) and smooth muscle myosin (from chicken gizzard) in vitro. using a sedimentation assay, the solubilities of the myosins were determined by measuring the amounts of myosin monomers (cm) and filaments (cp) present under a given set of conditions as a function of the total myosin concentration (ct). below 200 ... | 1987 | 3430607 |
| effects of endogenous pyrogen and prostaglandin e2 on hypothalamic neurons in rat brain slices. | we investigated the effects of endogenous pyrogen and prostaglandin e2 (pge2) on the preoptic and anterior hypothalamic (poah) neurons using brain slice preparations from the rat. partially purified endogenous pyrogen did not change the activities of most of the neurons in the poah region when applied locally through a micropipette attached to the recording electrode in proximity to the neurons. this indicates that partially purified endogenous pyrogen does not act directly on the neuronal activ ... | 1987 | 3497702 |