| effects of bromocriptine on adenylate cyclase and phosphodiesterase activities of rat striatum. | the activity of 2-bromo-alpha-ergokryptine (bromocriptine) (5 mg kg-1, i.p.) on adenylate cyclase and on phosphodiesterase (pde-pde ii) of rat striatum, has been examined both in vitro and in vivo. in vitro and in vivo bromocriptine stimulated adenylate cyclase activity, but reduced the stimulating effect of dopamine on adenylate cyclase activity. bromocriptine showed a dose-dependent biphasic action on phosphodiesterases in vitro while in vivo it stimulated them. the results obtained proved bro ... | 1978 | 24111 |
| effects of stimulants, anorectics, and related drugs on schedule-controlled behavior. | | 1978 | 24228 |
| active groups of extracellular endo-d-galacturonanase of aspergillus niger derived from ph effect on kinetic data. | in an attempt to characterize the groups essential for the catalytic action extracellular endo-d-galacturonanase of aspergillus niger (poly (1,4-alpha-d-galacturonide) glycanohydrolase, ec 3.2.1.15) the behaviour of the kinetic parameters as a function of ph was examined. the dependence of kcat and kcat/km on ph suggests that two dissociable groups are involved, for which the pk values of about 3.0 and 5.0 in the free enzyme and 3.06 and 5.72 in the catalytic complex were found at 30 degrees c. ... | 1978 | 24473 |
| neurogenic vasodilation of cat cerebral arteries. | transmural nerve stimulation (tns) with 0.3-msec pulses between 1 and 25 hz dilated cat cerebral artery segments in the presence of active muscle tone. maximum vasodilatation occurred at 8 hz. the dilator response to exogenous acetylcholine, but not to tns, was abolished by atropine. neither physostigmine nor hemicholinium affected the dilator response to tns, which persisted after administration of guanethidine, phenoxybenzamine, propranolol, reserpine, and chronic sympathectomy. however, it wa ... | 1978 | 24505 |
| the use of gvh methods in analysis of the b-complex. | | 1977 | 24559 |
| inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (momordica charantia abbreviata). | we have recently described the presence of a guanylate cyclase gtp pyrophosphate-lyase (cyclizing), ec 4.6.1.2 inhibitor (gci) in an aqueous extract of the balsam pear (momordica charantia abbreviata). because the guanylate cyclase-cyclic gmp system is though to be involved in cell growth, dna and rna synthesis, and possible malignant transformation, we examined the effect of the aqueous extract containing gci on an undifferentiated adenocarcinoma of the rat prostate and concanavalin-a-stimulate ... | 1978 | 24847 |
| exacerbations of chronic bronchitis: exogenous or endogenous infection? | six male patients with chronic bronchitis, who were known previously to have excreted streptococcus pneumoniae and/or haemophilus influenzae, both at the times of exacerbations and during remission, were studied for 43 to 52 months. sputum was examined fortnightly and at the time of exacerbations. strains of strep. pneumoniae were serotyped and those of haemophilus species were typed by antibiograms along with other supporting methods. sera collected before or at the time of an exacerbation and ... | 1978 | 25664 |
| bacteriological findings in the transtracheal aspirate from patients with acute exacerbation of chronic bronchitis. | transtracheal aspirates from 87 patients with acute exacerbations of chronic bronchitis who had received no recent antibiotic treatment were examined. a single bacterial species was found in 83% of positive cultures. predominant pathogens were haemophilus influenzae and streptococcus pneumoniae which occurred jointly or separately in 50% of positive cultures. bacteria traditionally considered as non-pathogenic for the lower respiratory tract also appeared to play an aetiological role. enterobact ... | 1978 | 25845 |
| the detection of bacterial antigens by counter-immunoelectrophoresis in n. meningitidis, h. influenzae serotype b, s. pneumoniae infections. diagnostic value and evolutive aspect (in 216 cases) (author's transl). | using counterimmunoelectrophoresis (cie) the authors have assayed for soluble bacterial s. pneumoniae, n meningitidis group a, b, c. h. influenzae type b antigens, biological fluids in 216 patients (meningitis: 136; pneumonia: 76; miscellaneous: 4) during 16 months. because of heterogeneous recruiting (the bacteriology was carried out by different laboratories) the increase in aetiological diagnosis given by cie is only statistically valid for the bacteriologic negative group when blind antibiot ... | 1977 | 26041 |
| comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy (author's transl). | the gastrointestinal blood loss caused by the two antirheumatic drugs acetyl salicylic acid (asa) and 4-acetamidophenyl-2-acetoxybenzoate (benorilate, benortan) was compared in experimental animals and humans by measuring the total body iron retention. in wistar rats and humans the results indicate that the daily iron loss under asa is significantly higher (almost by the factor 2) than that under benorilate. | 1978 | 26360 |
| antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. report of a study group on bacterial resistance. | twenty laboratories in england and scotland took part in 1977 in a survey of antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. in str pneumoniae 59 (6.8%) of the 866 strains studied were resistant to tetracycline and three to chloramphenicol, and one strain showed a decreased susceptibility to penicillin. the prevalence of resistance to tetracycline was lower than that found in a similar study performed in 1975. nine hundred and fifty-two strains of h influenzae were ... | 1978 | 26450 |
| the metabolism of (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid in chimpanzee and man. | the metabolism of the polyvalent saluretic agent (2-cyclopentyl-6,7-dichloro-2-methyl-1-oxo-5-indanyloxy)acetic acid was studied in chimpanzee and man. the drug was well absorbed and extensively metabolized by man. peak levels of drug (5--8 microgram/ml) occurred within 1.5--4.5 hr of drug administration. the plasma half-life was estimated to be 2 hr; a similar half-life was observed in the chimpanzee. little unchanged drug (less than 10%) was excreted in the urine of either species. similar met ... | 1978 | 26552 |
| effect of amisyl and spasmolytin on the blood supply and oxygen metabolism of the brain. | the effect of benactyzine and spasmolytin adiphenine on the blood circulation in the oxygen consumption by the brain were investigated in experiments on dogs. the resulting data point to a biphasic action of benacyzine and spasmolytin on the blood supply of the brain (after a short-lived increase of the blood flow a clearcut decline of it is noted). the oxygen intake from the blood varies irregularly. in chlorophos-poisoned dogs the oxygen absorption by the brain changes under the effect of bena ... | 1978 | 26597 |
| bacterial etiology of otitis media during the first six weeks of life. | tympanocentesis was performed on 70 infants who had otitis media during the first six weeks of life. the bacteria isolated from their middle-ear effusions were streptococcus pneumoniae (13 patients), neisseria catarrhalis (11 patients), hemophilus influenzae (ten patients), enterobacteriaceae (four patients), staphylococcus aureus (four patients), streptococci (groups a and b) (three patients), and pseudomonas aeruginosa (two patients). thirty patients (42.9%) had middle-ear effusions which did ... | 1978 | 26735 |
| a modified agar diffusion assay for amphotericin b. | | 1978 | 26759 |
| type-iii allergic reactivity to diplococcus pneumoniae and encapsulated haemophilus influenzae in passively sensitized mice and rats. | | 1978 | 26860 |
| effect of prior antibiotic therapy on concentrations of bacteria in csf. | a prospective study was done to determine the effect of prior antibiotic therapy on concentrations of bacteria in csf at the time of diagnosis. concentrations of haemophilus influenzae type b in csf of partially treated patients were significantly smaller than in csf of untreated patients. this was also true of patients with meningococcal meningitis, but no difference was observed between patients with pneumococcal meningitis. the identification of h influenzae by gram stain of csf was significa ... | 1978 | 27090 |
| neurochemical anatomy of the neuroendocrine hypothalamus. neurochemical anatomy of the hypothalamus. | microdissection techniques for isolated removal of the various regions of the hypothalamus as well as the individual hypothalamic nuclei are detailed. recent development of biochemical microassays have made it possible that the concentrations of neurohormones, neuropeptides, neurotransmitters and their related enzymes could be detected in such a small volume of brain tissue than the hypothalamic nuclei. data available of the hypothalamic distribution of above substances are summarized. the possi ... | 1978 | 27266 |
| immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans. | we have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from klebsiella pneumoniae which served as an immunoadjuvant. thus vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. a total of 104 men working for the commissariat à l'energie atomique, all volunteers, were randomly placed into two groups. during the first period, 51 patients (group i) were vaccinated three times a week during 5 w ... | 1978 | 27461 |
| red cell oxygen affinity in fetal sheep: role of 2,3-dpg and adult hemoglobin. | studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (dpg), the intracellular red cell and extracellular ph, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. adult hemoglobin first appeared near 120 days of gestation. the mean oxygen tension at which hemoglobin is half saturated (p50) prior to 120 days of gestation remained constant at 13.9 +/- 0.3 (sd) torr and ... | 1978 | 27486 |
| epr investigation of the mn(ii) binding sites in glutamine synthetase (escherichia coli w). i. high-affinity binding sites. | | 1978 | 27502 |
| the leeuwenhoek lecture, 1977. mouse teratocarcinoma and mouse embryo. | | 1978 | 27802 |
| tissue ph measurement proceedings. | | 1978 | 28161 |
| na+-k+-activated adenosinetriphosphatase as a trigger in transmitter release. | | 1978 | 28496 |
| research of the soluble microbial substances in organic fluids for the rapid diagnosis of some infections and particularly of bacterial meningitis (author's transl). | a number of immunological and non-immunological techniques have been recently used to detect soluble microbial substances in body fluids of patients with acute meningitis, bacteremia, and lobar pneumonia. by the immunological methods capsular highly polymerized polisaccharide group- or type-specific antigens of the most common c. n. s. pathogens (n. meningitidis a, b, and c; str. pneumoniae, h. influenzae type b, e. coli k1, mucoid pseudomonas, cryptococcus neoformans) can be detected and quanti ... | 1977 | 28697 |
| deoxycytidine: a morphine antagonist. | deoxycytidine antagonizes the analgesic action of morphine in the rat, morphine-induced respiratory depression in the rabbit and mitigates withdrawal in the dependent mouse. administration of deoxycytidine does not precipitate the abstinence syndrome in dependent mice, a property shared by certain other endogenous morphine antagonsits. cytidine and thymidine closely related in structure to deoxycytidine, are interchangeable with saline as controls, indicating a high degree of specificity in the ... | 1978 | 28700 |
| bacteriologic flora of aspiration-induced pulmonary infections. | the role of anaerobic and aerobic microorganisms in the genesis of pneumonia or lung abscess in patients with historical, clinical, and radiologic findings suggestive of aspiration was compared to their role in similar patients without these findings. bacterial specimens were obtained by transtracheal aspiration or thoracentesis. anaerobes were isolated in 100% of the patients who were aspiration-prone as contrasted with only 20% of those who were not. isolation of a single species or no growth ... | 1975 | 28705 |
| a spectral probe near the subunit catalytic site of glutamine synthetase from escherichia coli. reduced pyridoxal 5'-phosphate.enzyme complexes. | in order to label phosphate binding sites, unadenylylated glutamine synthetase from escherichia coli has been pyridoxylated by reacting the enzyme with pyridoxal 5'-phosphate followed by reduction of the schiff base with nabh4. a complete loss in mg2+-supported activity is associated with the incorporation of 3 eq of pyridoxal-p/subunit of the dodecamer. at this extent of modification, however, the pyridoxylated enzyme exhibits substantial mn2+-supported activity (with increased km values for at ... | 1978 | 29046 |
| state and rhythmic processes. | | 1978 | 29061 |
| otitis media in infants less than 12 weeks of age: differing bacteriology among in-patients and out-patients. | | 1978 | 29086 |
| the midwife and human prosperity. | | 1978 | 29283 |
| evaluation of the counterimmunoelectrophoretic (cie) procedure in a clinical laboratory setting. | the counterimmunoelectrophoretic (cie) procedure was evaluated under clinical laboratory conditions to determine its validity and comparability with culture methods. the procedure was further evaluated to determine applicability to a variety of clinical samples. an inexpensive set-up was developed to utilize the cie procedure at bench level. results indicated the procedure to be sensitive in detecting haemophilus influenzae, type b, and neisseria meningitidis (meningococcus), group b. the proced ... | 1978 | 29483 |
| antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. | | 1978 | 29689 |
| effects of psychotropic drugs on the spinal ventral root reflexes in cats. a comparison of the depressant actions in intact and spinal preparations (author's transl). | effects of the typical psychotropic drugs such as neuroleptics, tricyclic antidepressants and benzodiazepines on the monosynaptic reflex (msr) and polysynaptic reflex (psr) were investigated using intact and spinal cats. drugs used were chlorpromazine, levomepromazine, perphenazine, prochlorperazine, droperidol, haloperidol, amitriptyline, imipramine, diazepam and flurazepam. neuroleptics depressed the ventral root reflexes markedly to slightly in both preparations. the inhibitory effects of the ... | 1978 | 29826 |
| viruses and bacteria associated with acute respiratory illnesses in young children in general practice. | the results obtained and the laboratory methods used for the isolation of viruses and bacteria from malaysian children with acute respiratory illnesses seen in a private clinic are described. of the 65 children studied virus isolations were obtained from 26 children, bacteria from 10 and both virus and bacteria from another 5. the agents isolated were influenza viruses, parainfluenza viruses, adenoviruses, bordetella pertussis, streptococcus pneumoniae, haemophilus influenzae and staphylococcus ... | 1978 | 30173 |
| bacteriology of maxillary sinusitis in relation to quality of the retained secretion. | the bacteriological findings in 200 patients with acute maxillary sinusitis are reported. it is concluded that the sampling technique--by antral aspiration--is highly significant in the evaluation of the bacteriological background of sinusitis, whereas the anerobic transport of the sample seems to be of less importance. by aspiration the purulent secretion can be properly separated from the non-purulent secretion. pneumococci, h. influenzae and anaerobic bacteria can be isolated in about 90% of ... | 1978 | 30255 |
| bacterial meningitis: the beginning of the end. | | 1978 | 30281 |
| antibiotic resistance in streptococcus pneumoniae and haemophilus influenzae. | | 1978 | 30516 |
| european society of human genetics. abstracts from symposium on "chromosome structure and function". vienna, austria, may 5-7, 1978. | | 1978 | 30557 |
| dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine. | | 1978 | 30675 |
| the absorption and sputum penetration of doxycycline. | | 1978 | 30746 |
| microbiology of recurrent and chronic otitis media with effusion. | a study was conducted of 274 children who had recurrent acute or chronic otitis media with effusion. forty-five percent of the ears with effusion were found to contain bacteria, and 11% contained bacteria that were "probable pathogens" (s. pneumoniae, h. influenzae, and s. pyogenes). bacteria were also found in 40% of the ears without effusions. the type of organism found did not vary with the age of the patient studied or the season of the year. the significance of these bacteria in the etiolog ... | 1978 | 30809 |
| treatment of acute otitis media of infancy with cefaclor. | the emergence of ampicillin-resistant haemophilus as a clinical problem in otitis media necessitates a search for alternative, effective therapy. an orally absorbable cephalosporin derivative, cefaclor, is equally effective in vitro against ampicillin-susceptible and -resistant haemophilus and against other bacteria that cause acute otitis media. two dosage schedules of cefaclor (40 and 60 mg/kg/day) were evaluated in 95 infants with acute otitis media. bacterial origin was determined by a cultu ... | 1978 | 31084 |
| [the intragastral antibacterial effect and its importance in chronic enterocolitis]. | | 1978 | 31275 |
| (exo, exo)-2-aryltropane-3-carboxylic esters, hypoglycemic agents with accompanying analgesic activity. | (exo, exo)-2-aryltropane-3-carboxylic esters of types 6, 7, and 10 lower circulating blood glucose levels by 60--80%. this activity is accompanied by an analgesic activity roughly equal to that of codeine. both of these activities reside in the 1r enantiomer and extensive structure-activity studies failed to separate them. the specific opioid antagonist nalorphine blocks the analgesic activity but does not diminish the hypoglycemic action. conformational integrity afforded by the ethylene bridge ... | 1978 | 31482 |
| [the efficacy of a maintenance dose of 100 mg doxycycline (vibramycin) daily in bacterial infections of chronic bronchitis (author's transl)]. | the efficacy and tolerance of a daily maintenance dose of 100 mg doxycycline (vibramycin) was investigated in ambulant patients with chronic obstructive pulmonary disease (copd) and bacterial infection by an open study with clinical, bacteriological and cytological control. the dosage was well tolerated and effective in the elimination of h. influenzae and pneumococci. a higher maintenance dose seems not to be necessary for this type of infections. | 1978 | 31554 |
| [treatment of chronic bronchitis with supristol and a cotrimoxazole preparation--comparative bacteriological and clinical findings, results of a double-blind study (author's transl)]. | in a randomized double-blind study on the treatment of chronic bronchitis, supristol (co-trifamole) was compared with co-trimoxazole. 163 patients participated in the clinical trial that was performed at three different hospitals in accordance with a uniform trial plan. the microbiological investigations were done centrally at a hygiene institute for all three hospitals. the bacteriological results from the 61 patients whose antibiogram revealed sensitive pathogens before starting the therapy de ... | 1978 | 31555 |
| the use of bacteria for the functional characterization of human lymphocyte subpopulations in various lymphoid organs. | in a haemolytic plaque assay staphylococcal strain cowan 1 was shown to induce polyclonal antibody secretion in human blood lymphocytes, whereas haemophilus influenzae and escherichia coli gave low responses. diplococcus pneumoniae and haemolytic streptococci generally did not activate blood cells. all five bacteria could activate spleen, tonsil and adenoid cells both to polyclonal ig secretion and increased dna synthesis. thus blood cell reactivity does not necessarily reflect the response patt ... | 1978 | 31677 |
| serological methods for rapid diagnosis of haemophilus influenzae, neisseria meningitidis and streptococcus pneumoniae in cerebrospinal fluid: a comparison of co-agglutination, immunofluorescence and immunoelectroosmophoresis. | | 1978 | 31678 |
| hr 756, the syn isomer of a new methoxyimino cephalosporin with unusual antibacterial activity. | hr 756, the syn derivative of 7-[(2-(2-amino-4-thiazolyl)-2-methoxyimino)acetamido]cephalosporanic acid, is a new semisynthetic cephalosporin. it was 80 times more active than the anti derivative against beta-lactamase-producing strains of gram-negative bacteria. the range of inhibitory concentrations of hr 756 against gram-negative bacteria, including haemophilus influenzae, susceptible or resistant to penicillins and cephalosporins was from 0.01 to 0.1 mug/ml. this activity was consistently hi ... | 1978 | 31836 |
| metabolic activation of 2,4-diaminoanisole, a hair-dye component--ii. role of cytochrome p-450 metabolism in irreversible binding in vitro. | | 1979 | 31890 |
| [bacterial allergy in asthmatic syndromes]. | | 1976 | 31959 |
| prospects for the prevention of bacterial meningitis with polysaccharide vaccines. | most suppurative infections of the meninges are caused by five bacterial species: escherichia coli, haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus. the immune response of adults to pneumococcal capsular polysaccharides has been studied in great detail and their responses to meningococcal and h. influenzae type b capsular polysaccharides are quite similar. immune responses of adults to e. coli and group b streptococcal antigens are disap ... | 1978 | 31985 |
| twice daily dosage of bacampicillin in chronic bronchitis. a double-blind study. | three groups of patients (total 48) with acute exacerbations of chronic bronchitis were treated orally for 10 days, in a double-blind clinical trial, with bacampicillin (an ampicillin ester) 1600 mg twice daily, 800 mg three times daily and oral ampicillin 1000 mg three times daily. most exacerbations were caused by haemophilus influenzae or streptococcus pneumoniae. clinical and bacteriological results were significantly more favourable in the two bacampicillin-treated groups. both drugs were g ... | 1978 | 32615 |
| purification and properties of a new restriction endonuclease from haemophilus influenzae rf. | haemophilus influenzae rf 232, showing the phenomena of restriction and modification, contains an endonuclease that inactivates in vitro the biological activity of dnas lacking the strain-specific modification. this specific restriction endonuclease has been purified to near homogeneity by a procedure that includes dna-agarose chromatography. this highly purified enzyme requires atp and mg2+ for activity and is stimulated by s-adenosylmethionine. the enzyme seems to cleave dna at well-defined si ... | 1978 | 33045 |
| opportunist lung infections. | | 1979 | 33268 |
| [bacterial polysaccharides--a new generation of vaccines]. | | 1979 | 33301 |
| kinetic studies in isolated organs: tools to design analgesic peptides and to analyze their receptor effects. | the opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (gpi) and in mouse vas deferens (mvd). the comparison of agonist activities of peptides found in gpi and mvd offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. the kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. using c-6 epimers of naltrexone, it was found ... | 1979 | 33396 |
| counterimmunoelectrophoresis of sputum and blood for the diagnosis of chest infections caused by pneumococci or haemophilus influenzae. | in 107 patients with lower respiratory tract infections, counterimmunoelectrophoresis (cie) of blood and sputum, bacterial cultures of blood, sputum and nasopharyngeal secretion, and enzyme-linked immunosorbent assay (elisa) for antibody determination were performed, with special reference to pneumococci and haemophilus influenzae. for pneumococci cie of sputum was superior to culture especially in antibiotic-treated patients. the clinical significance of a positive cie of sputum was supported b ... | 1979 | 33446 |
| effect of growth conditions on the antigenic components of streptococcus mutans and lactobacilli. | 1) the release of lta from chemostat-grown cultures of s. mutans and l. fermentum is dependent on the generation time and ph. 2) the growth rate affects the immunogenicity of lta and the wall polysaccharide of l. fermentum. 3) the growth of l. plantarum under glucose limitation influences the glucose content of the wall teichoic acid. the composition of the wall polysaccharide of s. mutans ingbritt may also be changed under these conditions. 4) the conditions of autoclaving used to release cell ... | 1978 | 33543 |
| diagnosis and treatment: drugs five years later. amoxicillin. | amoxicillin is an aminopenicillin available in the united states only for oral use. it has an antibacterial activity and spectrum similar to that of ampicillin and is destroyed by gram-positive and gram-negative beta-lactamases. it is more active against enterococci and salmonellae than ampicillin, but less active against shigella. it is better absorbed than ampicillin from the gastrointestinal tract with blood levels two to two and one half times those of ampicillin. amoxicillin is an excellent ... | 1979 | 34342 |
| [phenomenon of parental resistance and its genetic regulation]. | lymphocytes of mice f1 (cba x m523) and f1 (a x m523) transplanted to 1000 r irradiated cba or a mice responded to the test antigens--srbc or s. typhi vi-antigen--by formation of 100--1000 times less antibody forming cells than in syngeneic recipients. an intermediate result is achieved when the lymphoid cells are transplanted to the irradiated m523 mice. lymphocytes of mice f1 (a x cba), f1 (cba x c57bl/6), or f1 (a x a.ca) developed a similar immune response in the irradiated syngeneic mice an ... | 1979 | 34452 |
| studies on the structure-activity relationship of adrenergic beta-mimetic benzylamine derivatives. iv.1) aryl-substituted 1-aminotetralins and 1-aminoindans. | | 1978 | 34486 |
| [comparative sensitivities of six different species of mosquitoes to bacillus thuringiensis var. israelensis]. | | 1979 | 34488 |
| comparison of staphylococcal coagglutination, latex agglutination, and counterimmunoelectrophoresis for bacterial antigen detection. | soluble antigens of haemophilus influenzae type b, streptococcus pneumoniae, neisseria meningitidis, and group b streptococcus were looked for in cerebrospinal fluid, serum, and urine by using the staphylococcal coagglutination test, latex agglutination test, and counterimmunoelectrophoresis. the staphylococcal coaggultination and latex agglutination tests were more sensitive than counterimmunoelectrophoresis in identifying antigens of h. influenzae type b, s. pneumoniae, and n. meningitidis. no ... | 1979 | 34622 |
| evaluation of blood culture procedures in a pediatric hospital. | to determine optimal clinical laboratory techniques for detecting pediatric bacteremia, we studied 7,768 consecutive blood cultures in a 1-year period. blood was inoculated into one vented 50-ml bottle of brucella broth with 0.05% sodium polyanetholsulfonate and one unvented 50-ml bottle of columbia broth with 0.05% sodium polyanetholsulfonate and 0.05% cysteine. bottles were visually examined for growth on days 1 through 7 and blindly subcultured aerobically and anaerobically on days 1, 2, and ... | 1979 | 34623 |
| chromogenic cephalosporin spot test to detect beta-lactamase in clinically significant bacteria. | lactamase production. reacteroides melaniongenicus, 14 | 1979 | 34624 |
| the nasopharyngeal culture in acute otitis media. a reappraisal of its usefulness. | simultaneous cultures of the nasopharynx and middle ear exudate (obtained by tympanocentesis) were obtained from 225 children (mean age, 34 months; median age, 41 months) with suppurative otitis media. a 72% prediction rate for middle ear pathogens was obtained by examining the nasopharyngeal cultures after the strict observance of two essential prerequisites: (1) the nasopharyngeal culture was immediately plated on appropriate solid agar and (2) a semiquantitative method for bacterial enumerati ... | 1979 | 34739 |
| [rolitetracycline in lung and biliary tract infections]. | | 1979 | 34790 |
| [modern data on the antibiotic sensitivity of the microflora that is an etiological factor in ent diseases. ii. the antibiotic sensitivity of pneumococci, meningococci, influenza bacilli, klebsiella, enterobacteria, pseudomonas aeruginosa and proteus]. | | 1979 | 34945 |
| k+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: obliteration by amiloride. | | 1979 | 35009 |
| etiology and antimicrobial therapy of acute maxillary sinusitis. | eighty-one adults with symptoms of acute sinusitis were studied by direct needle puncture and aspiration of the maxillary sinus (105 sinuses). fifty-nine bacterial strains were isolated in titers of greater than or equal to 10(4) colony-forming units/ml; streptococcus pneumoniae and haemophilus influenzae accounted for 64% of the isolates. other bacteria recovered included anaerobes (12%), neisseria species (8.5%). streptococcus pyogenes (3%), alpha-hemolytic streptococcus (3%), non-group a beta ... | 1979 | 35571 |
| [treatment of bacterial meningitis with cefamandole]. | | 1978 | 35821 |
| otitis media in children: a prospective study of aerobic and anaerobic bacteriology. | tympanocentesis with aerobic and anaerobic cultivation of middle ear fluid was performed through one or both tympanic membranes of 186 children with acute otitis media. aerobic bacteria alone, predominantly pneumococcus and hemophilus influenzae, were isolated from 118 (63.4%) patients: and anaerobic organisms alone, most commonly peptococcus, from 24 (12.9%). twenty-six (14%) yielded mixtures of aerobes and anaerobes, and several had multiple aerobic agents. no bacterial growth was noted in 18 ... | 1979 | 36523 |
| the microbiology of serous and mucoid otitis media. | one hundred forty-four serous and mucoid effusions were cultured for aerobic bacteria, mycoplasma pneumoniae, and virus. thirty percent of all effusions yielded an unequivocally positive culture for aerobic bacteria. although serous effusions were culture positive as often as mucoid effusions, haemophilus influenzae was isolated predominantly from serous effusions and staphylococcus epidermidis predominantly from mucoid samples. only one of 73 effusions yielded a viral isolate (herpesvirus homin ... | 1979 | 36591 |
| otitis media with effusion. cytological and microbiological correlates. | a quantitative cytologic study of 83 middle ear effusions from children with otitis media with effusion (ome) was made with the use of cytocentrifuge-prepared smears and was correlated with bacteriological findings. the identification of the types of cell present in an effusion was confirmed by electron microscopic findings. the most common cell types were neutrophilic leukocytes, lymphocytes, and macrophages, but a few eosinophils were found in only one case. the cytologic profile of an effusio ... | 1979 | 36875 |
| cefuroxime: a review of its antibacterial activity, pharmacological properties and therapeutic use. | cefuroxime is a new semisynthetic cephalosporin for parenteral administration. it is resistant to destruction by beta-lactamases produced by staphylococci and most gram-negative aerobic bacteria and is active against many bacteria resistant to cephalothin. cefuroxime is the most active of the cephalosporins against gonococci and haemophilus influenzae particularly against beta-lactamase producing strains. given by intramuscular or intravenous injection cefuroxime is effective against a wide vari ... | 1979 | 37064 |
| cellulitis of the face caused by hemophilus influenzae during childhood. | | 1979 | 37202 |
| upper respiratory tract spread of group b streptococci type i b in a kindergarten. | in a kindergarten with 42 children and 17 female staff members, an epidemic of group b streptococcal carriage in the upper respiratory tract occurred. in the middle of february 1978, 6 children and 5 adults carried type i b streptococci in the throat while only 2 of these 11 were carriers 2 weeks later. only one other streptococcus, belonging to type ii, was found in the throat specimens. five strains other than type i b were found in the urogenital tract of the staff. three type i b throat carr ... | 1979 | 37592 |
| bactericidal action of an average dose of erythromycin in the bronchi. | a study was carried out to establish whether erythromycin stearate was bacteriostatic or bactericidal at the concentrations reached in the bronchial secretion. twenty-two patients suffering from an acute attack of chronic bronchitis, sustained by streptococci, diplococci, staphylococci or h. influenzae sensitive to erythromycin, were treated with 1500 mg erythromycin per day until symptoms regressed, usually within 3 to 5 days. the results showed that after treatment there was a dramatic reducti ... | 1979 | 38063 |
| report of iabs committee on avian product standardization. | the international association of biological standardization (iabs) organized an international symposium in august 1973 on the "requirements for poultry virus vaccines" at lyon (france). the proceedings of this symposium were subsequently published as "developments in biological standardization", volume 25. at the conclusion of this symposium, it was resolved that an avian biological products standardization committee should be established, this committee including four subcommittees, each under ... | 1978 | 38158 |
| pharmacokinetics and tolerability of a single oral 600-mg dose of doxycycline. | the pharmacokinetics of a single orally administered 600-mg dose of doxycycline (six 100-mg film-coated tablets) was studied in 18 healthy subjects. plasma doxycycline levels remained above 1.35 mumol/l for 48 hours and compared favourably with the mean inhibitory concentrations of doxycycline against the common infecting organisms in chronic bronchitis. in a separate tolerability study in 37 healthy subjects, there was no significant difference between doxycycline and placebo in the incidence o ... | 1979 | 38382 |
| detection of experimental bacteremia and fungemia by examination of buffy coat prepared by a micromethod. | rabbits received intravenous injections of bacteria or fungi, and a comparison was made of the abilities of broth cultures, plating after dilution either in saline solution or in distilled water containing triton x-100, and buffy coat examinations to detect the organisms in heart blood. the most sensitive method was broth culture. by microscopy or subculture of buffy coat cells prepared by centrifugation of blood in microhematocrit tubes, organisms were rapidly and regularly detected when their ... | 1979 | 38662 |
| bactericidal and bacteriostatic action of chloramphenicol against memingeal pathogens. | the bacteriostatic and bactericidal effects of chloramphenicol, ampicillin, tetracycline, and sulfisoxazole were compared against several potential meningeal pathogens. chloramphenicol is bactericidal at clinically achievable concentrations against haemophilus influenzae, streptococcus pneumoniae, and neisseria meningitidis. it is bacteriostatic against gram-negative bacilli of the family enterobacteriaceae and against staphylococcus aureus. chloramphenicol has proven highly efficacious in the t ... | 1979 | 38742 |
| [antibiotics therapy in chronic bronchitis]. | in chronic bronchitis antibiotic therapy is no causative therapy, because infection rarely is the beginning but the complication of an already existing airway disease. while sputum cultures are very limited in their value, blind chemotherapy of bacterial infections by substances like tetracycline, ampicilline, azidocilline or cotrimoxazole is allowed. in cases of additional obstruction a combination with corticosteroids sometimes may be useful. | 1979 | 39882 |
| use and efficacy of pneumococcal vaccine in patients with hodgkin disease. | fulminant bacterial sepsis has been described in patients with hodgkin disease who have undergone splenectomy for staging purposes. the organisms commonly associated with sepsis in this setting include streptococcus pneumoniae and haemophilus influenzae. polyvalent pneumococcal vaccine (merck) has recently been licensed and has been suggested for use in patients with hodgkin disease who are at risk for postsplenectomy sepsis. we administered 14-valent pneumococcal vaccine to 24 patients with hod ... | 1979 | 40635 |
| pathogenic species of the genus haemophilus and streptococcus pneumoniae produce immunoglobulin a1 protease. | thirty-seven strains of the genus haemophilus and five strains of streptococcus pneumoniae were examined for their ability to produce extracellular enzyme that cleaves immunoglobulin molecules. all strains of h. influenzae, h. aegyptius, and s. pneumoniae elaborated enzyme that selectively cleaved human immunoglobulin a1 (iga1) myeloma proteins but was inactive against a variety of other proteins including human iga2, igg, and igm, porcine and bovine secretory iga, human and bovine serum albumin ... | 1979 | 40878 |
| bacterial adherence to pharyngeal cells in smokers, nonsmokers, and chronic bronchitics. | selective adherence to host mucosal surfaces is probably a requirement for colonization and infection by bacteria. since pharyngeal colonization may be an important determinant in the pathogenesis of pneumonia, we studied the adherence of 10 different bacteria to pharyngeal cells obtained from nonsmokers, smokers, and chronic bronchitics. various patterns of adherence among the different groups of subjects were found. young healthy smokers had increased adherence of streptococcus pneumoniae type ... | 1979 | 40879 |
| immunoglobulin a1 protease production by haemophilus influenzae and streptococcus pneumoniae. | bacterial strains of haemophilus species and streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin a1 (iga1) protease. of 36 h. influenzae strains examined, 35 produced iga1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable h. influenzae. eight haemophilus strains (non-h. influenzae) were studied, and two produced iga1 protease. all 10 strains of s. pneumoniae produced iga1 protease; these strains included 9 dif ... | 1979 | 40880 |
| [a bacteriological investigation of acute purulent otitis media (author's transl)]. | | 1979 | 41035 |
| [range and possibilities of treatment of chronic bronchitis and its complications]. | | 1979 | 41227 |
| [culture and morphological characteristics of haemophilus influenzae and pneumococcus in bronchial infection]. | in the cultures obtained by inoculating sputum samples faken from patients with bronchial infection into solid agar medium prepared on hottinger's hydrolysate with fresh rabbit blood added haemophilus influenzae produced colonies varying in their from (dome-shaped, conical, trapeziform), as well as in the morphology of the organisms. pneumococci produced mainly flat colonies surrounded by the zone of alpha hemolysis. along-side with isolated h. influenzae and pneumococcal colonies, symbiotic col ... | 1979 | 41387 |
| [bacterial coincidence in the infected middle ear and nasopharynx (author's transl)]. | | 1979 | 41890 |
| [action of aortic cathepsin d on serum low-density lipoproteins]. | action of aortic cathepsin d on low density lipoproteins /ldl/ from human serum was studied by means of analytical ultracentrifugation. cathepsin d intensively hydrolysed ldl, leading to decrease in the sedimentation coefficients of the product formed. the product of degradation of ldl possessing a sedimentation coefficient of 4.5 s /in 0,04 m kbr; 0,042 m nacl, 2 mm edta, 6 mm tris, ph 7.3 /contained apparently the minimal amount of proteins, which could still maintain the stability of partiall ... | 1979 | 42218 |
| should we plan a general childhood vaccination against bacterial meningitis? | an estimation of the benefits of vaccination against bacterial meningitis are based on the age-specific incidence of meningitis caused by the different groups of meningococci, by haemophilus influenzae and by pneumococci, and the known efficacy of the present polysaccharide vaccines against these agents. since the incidence of bacterial meningitis is more than ten times higher below the age of five years that at a later age, vaccination at 1 1/2 years of age could prevent a large fraction of all ... | 1979 | 42596 |
| an evaluation of 12 methods for the demonstration of penicillinase. | twelve methods for the demonstration of bacterial penicillinase production by strains of haemophilus influenzae and staphylococcus aureus are compared, and their suitability for routine clinical laboratory use is evaluated. the acidometric agar plate method is recommended. | 1979 | 42650 |
| [the bacteriological diagnosis of pneumonia by transtracheal puncture. value in medical intensive care (author's transl)]. | seventy five patients referred with a diagnosis of pneumonia underwent transtracheal puncture. in 76% of cases this examination led to discovery of an organism in infected patients. in 50% of cases, the bacteriological diagnosis was sufficiently accurately oriented by direct examination to permit rapid and effective treatment. there was virtually perfect agreement with the results of blood cultures when the latter were positive. the organisms most often responsible were gram positive and above a ... | 1979 | 42881 |
| opsonic activity of normal human cerebrospinal fluid for selected bacterial species. | the opsonic activity of normal human cerebrospinal fluid (csf) has not been well defined. in this study, the opsonic activity of normal csf for laboratory and blood culture isolates of staphylococcus aureus, streptococcus pneumoniae, escherichia coli, hemophilus influenzae type b, and neisseria meningitidis was measured by a quantitative assay employing radiolabeled bacteria and polymorphonuclear leukocytes. all isolates of s. aureus, except the wood 46 strain, were opsonized in undiluted csf (> ... | 1979 | 43289 |
| comparative immunogenicity of group 6 pneumococcal type 6a(6) and type 6b(26) capsular polysaccharides. | the comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6a(6) and type 6b(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6a (u.s. designation, type 6) or 50 mug each of type 6a and type 6b (u.s. designation, type 26) polysaccharides. both group 6 polysaccharides were linear copolymers composed of 1 mol each of d-galacto ... | 1979 | 43290 |
| quantitative sputum gram stains in chronic bronchial disease. | | 1979 | 43418 |