| nuclear proteins of rat liver and of an aminoazo-dye-induced hepatoma. | nuclear proteins of rat liver and rat ascites hepatoma were fractionated by extraction in solutions of different salt concentration and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. the difference between the electrophorograms of the different fractions of nuclear proteins isolated from liver and from hepatoma was found in the bands which have the same electrophoretic mobility as the main proteins of informofers and are extracted from nuclei at salt concentrations which ... | 1975 | 168162 |
| functional and structural changes in isolated rabbit liver mitochondria induced by fluorodichloromethane. | fluorodichloromethane caused changes in substrate respiration rates and also in adenosine diphosphate (adp)-stimulated rates of oxidation of both succinate and glutamate. active swelling of mitochondria also occurred, but only in the presence of magnesium ion. adp/o ratios were not significantly affected by the fluorocarbon. state iv respiration was stimulated, and the respiratory control ratio was linearly reduced with increased levels of fluorocarbon when succinate was used as substrate. gluta ... | 1975 | 168346 |
| [a spectrophotometric method for the determination of serum cholinesterase variants with succinyl choline as substrate (author's transl)]. | a simple and rapid method for the estimation of the hydrolysis of succinyl choline by serum cholinesterase variants is described. succinyl choline, as substrate for the enzyme assay, has many advantages over other substrates (acetyl choline, benzoyl choline and butyryl choline) which have no clinical application. choline, the hydrolytic product of succinyl choline, is oxidized to betaine aldehyde by choline oxidase (ec 1.1.99.1), a rat liver mitochondrial preparation; this is coupled to the redu ... | 1975 | 168694 |
| characterization of cloned evolutionary variants of simian virus 40. | | 1975 | 169050 |
| structural aspects of the membrane of the endoplasmic reticulum. | | 1975 | 173395 |
| [proceedings: urinary excretion of cyclic amp during expansion in rats]. | | 1975 | 175173 |
| lupus nephritis: natural history and therapy. | | 1976 | 175347 |
| proceedings: attempts to infect inbred strains of rats and mice with entamoeba histolytica. | | 1975 | 175529 |
| [role of alimentary hyperglycemia in the pathogenesis of several disorders of lipid metabolism]. | alimentary hyperglycemia in rabbits was found to be accompanied by increase in cholesterol level, as well as in the amount of triglycerides in the blood sera. progressive increase in the serum concentration of pre-beta lipoproteids (serving as endogenous tryglyceride carrier) has also been demonstrated. a short-term feeding with cholesterol against the background of hyperglycemia in rabbits appeared to result in early marked atherosclerotic changes, as compared to those in control group of normo ... | 1976 | 182301 |
| some biological properties of human chorionic follicle stimulating hormone. | the biological properties of human chorionic fsh (hcfsh) for rat ovaries were investigated. highly purified hcfsh had similar response to the ovarian augmentation test as bovine fsh and significantly enhanced 3h-thymidine uptake by granulosa cells and theca cells in the ovary of hypophysectomized rat. in contrast, highly purified hcg little responded to the ovarian augmentation test and had no effect on 3h-thymidine uptake by the ovary. these results indicate that hcfsh may promote the follicula ... | 1975 | 182476 |
| avian leukosis viruses of different subgroups and types isolated after passage of rous sarcoma virus-rous-associated virus-0 in cells from different ring-necked pheasant embryos. | avian leukosis viruses of subgroups a and f (rav-a and rav-f) arose at a low rate after passage of rous sarcoma virus-rous-associated virus-0, which is subgroup e, in cells from ring-necked pheasant embryos. in cells of two embryos, all of the viruses isolated after virus passage were rav-f. however, in cells of a third embryo, both rav-a and rav-f were isolated. in addition, there sometimes were type-specific differences among the different isolates of rav-a and rav-f from the cells of single e ... | 1976 | 183006 |
| [herpesvirus-induced autoantibodies in animals (author's transl)]. | after immunization with autologous testicle cells which were infected with herpes virus hominis type 1 or 2, histologically homogeneous, eosinophilie pas-positive substances could be detected in five out of six rabbits, mainly within the interstitium. these substances have been found by immunofluorescence microscopic techniques to be antibodies against testicle tissue. | 1976 | 183633 |
| infectious murine type-c viruses released from human cancer cells transplated into nude mice. | type-c virus particles were revealed by electron microscope in 6 of 9 tumours of cultured and biopsied human cancers heterotransplanted into nude mice. some tumours in nude mice were explanted for in vitro cultivation. the virus particles were also found in the cultures derived from the virus-positive tumors. they were mostly found extracellularly, but the particles in budding process were also encountered frequently. cytological study and karyotype analysis of the cultured cells proved these vi ... | 1977 | 193756 |
| colloidal iron hydroxide-binding to the surfaces of chick embryo fibroblasts transformed by wild-type and a temperature-sensitive mutant of rous sarcoma virus. | the densities of colloidal iron hydroxide (cih) particles binding to the surfaces of chick embryo fibroblasts were determined before and after transformation with wild type rous sarcoma virus and a temperature sensitive (ts) mutant of this virus. on the basis of in vitro behavior, cells transformed by the ts virus manifest a malignant phenotype at 36 degrees c (permissive temperature) and appear normal at 41 degrees c (non-permissive temperature). at the permissive temperatures there is a signif ... | 1977 | 193866 |
| analogies and differences between reserpine pgo wave discharges and oculomotor phasic activity during paradoxical sleep in the cat. | in the present study the analogies and differences between phasic pgo activity of parodoxical sleep and the reserpine induced pgo waves were investigated. the oculomotor phasic activities in chronic cats were studied. it appeared that the intrinsic organisation of latencies and the appearance of phasic waves in the four structures studied were common to both experimental situations. however the sequential patterns of discharges were different in ps and under reserpine treatment. | 1977 | 195316 |
| the involvement of cyclic amp-dependent protein kinase(s) in the induction of ornithine decarboxylase in the regenerating rat liver and in the adrenal gland after unilateral adrenalectomy. | | 1977 | 195633 |
| an investigation of the homology of guanylate kinase isozymes in mammals and further evidence for multiple guk gene loci. | guanylate kinase in the red cells of 63 different mammalian species was studied by electrophoresis and multiple molecular forms of the enzyme were found in all species. two species were investigated in more detail. using molecular weight estimates as a criterion of homology, the fallow deer and the chinese hamster were found to have isozymes that corresponded to isozyme e, f, and g of man. variation in the guanylate kinase isozymes was detected in a small population of orangutans. results sugges ... | 1977 | 201245 |
| electron microscopic studies on equine infectious anemia virus (eiav). brief report. | morphological studies of eiav reveal knobs on the surface of the particles, conically and tubularly shaped cores, budding particles with dense crescents directly underlying the plasma membrane, and distinct intracytoplasmic structures in infected cells. | 1977 | 202230 |
| laryngeal abductor activity during sleep. | | 1978 | 202438 |
| vitamin d metabolism. | during the past decade, an explosion of information has become available on the metabolism and function of vitamin d which is of great importance to clinicians in the treatment of metabolic bone disease. we have learned that vitamin d is the precursor of at least one hormone and that this hormone carries out functions in calcium and phosphorus metabolism bringing about mineralization of bone on one hand, and the prevention of hypocalcaemic tetany on the other. it may also function in the prevent ... | 1977 | 203416 |
| in situ embedding method of cells grown in beem capsules for immunoelectron microscopic studies of oncornaviruses. | a technique of in situ embedding of cells grown in beem capsules has been devised for immunoelectron microscopic studies of oncornaviruses. as compared to other immunoelectron microscopic procedures, this technique is less time and reagent-consuming. the quality and specificity of this method were tested on well-characterized mouse mammary tumor virus (type b virus) and murine sarcoma virus (type c virus particles). this method gave good results in labeling of the virus particles with ferritin o ... | 1978 | 203626 |
| presynaptic muscarinic cholinergic receptors. | | 1978 | 203868 |
| the influence of crude cottonseed oil in the feed on the blood and egg yolk lipoproteins of laying hens. | lipovitellin, very low density lipoproteins (vldl), low density lipoproteins (ldl), high density lipoproteins (hdl), and proteins of d greater than 1.20 were isolated from blood plasma and egg yolks obtained from hens fed a normal diet or one containing 2.5% of crude cottonseed oil. the amounts and compositions of each fraction were determined. hen blood plasma and egg yolk vldl and ldl obtained from hens fed a normal diet contained similar levels of lipid, and the fatty acid compositions of tho ... | 1977 | 203909 |
| comparison of interferon action in interferon resistant and sensitive l1210 cells. | translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ... | 1978 | 212514 |
| effect of osteotropic hormones on cartilage metabolism. | | 1979 | 218877 |
| transcription of endogenous c-type viruses in resting and proliferating tissues of balb/mo mice. | | 1979 | 228474 |
| isolation of foot-and-mouth disease virus messenger rna from membrane-bound polyribosomes and characterization of its 5' and 3' termini. | | 1979 | 228483 |
| guinea pig very low density lipoproteins are a good substrate for lipoprotein lipase. | in contrast to plasma from most other animals, guinea pig plasma causes little or no stimulation of lipoprotein lipase activity. very low density lipoproteins (vldl) isolated by ultracentrifugation of guinea pig serum caused a definite stimulation of lipase activity, whereas the infranatant inhibited the activity. gel filtration in 5 m guanidinium hydrochloride of delipidated vldl demonstrated that the activation was caused by a low molecular weight protein. the vldl themselves were hydrolized a ... | 1979 | 229910 |
| letter: human pulmonary dirofilariasis: entry method of infective larvae. | | 1975 | 238798 |
| resistance and tolerance of myocardium in ischemia: experimental results. | the resistance of the normal myocardium to ischemia can be determined by the metabolic and electric investigations, and particularly by the determination of the intra-myocardial potentials. the aspect of v.f. and the metabolic changes allow aetiologic deductions on the v.f. and are helpful for the treatment. | 1975 | 239001 |
| action of the benzodiazepines on the cholinergic system. | | 1975 | 242203 |
| studies on the isolation and characterization of theilerial antigens: particularly on the applicability to passive hemagglutination test. | | 1979 | 261988 |
| reactivity of platelets with different collagens: overlook. | | 1978 | 262325 |
| bcg at the cross roads. | | 1979 | 263227 |
| [measurements of the temperature during the use of dental ultrasonic devices]. | this investigation worked at temperature measurements in cylindric pieces of copper for determination of surface temperatures and in root dentin of calves using ultrasonics by varying intensity, water flowing and pressure. in each experiment two different dental ultrasonic devices were used with two tips. the experiments with sufficient water flowing showed that the spray temperature which was determined separately in further experiments influenced the measurements mainly. on the other hand an i ... | 1978 | 271584 |
| [radioprotective action of aet and mexamine on pentose cycle dehydrogenases]. | | 1977 | 272004 |
| apparatus for uniaxial testing of soft human tissues in vitro. | | 1978 | 309051 |
| on the regional and specific serotonin uptake inhibition by lm 5008. | | 1978 | 310012 |
| ecophylaxis: preventive treatment with gentamicin of rabbit lincomycin-associated diarrhea. | in rabbits the oral or parenteral administration of lincomycin result in a severe and usually fatal form of diarrhea. the rabbits treated simultaneously with lincomycin and gentamicin do not present any sign of disease and behave exactly, therefore, as the control subjects. the same occurs in subjects treated with gentamicin alone. in all the subjects which died with diarrhea there was a marked alteration of the intestinal bacterial flora. among the aerobic bacteria there was an overgrowth of co ... | 1977 | 350739 |
| birthday of a sacred cow. | | 1978 | 351578 |
| gel filtration of sialoglycoproteins. | the role of sialic acid in the gel-filtration behaviour of sialoglycoproteins was investigated by using the separated isoenzymes of purified human liver alpha-l-fucosidase and several other well-known sialic acid-containing glycoproteins (fetuin, alpha1-acid glycoprotein, thyroglobulin and bovine submaxillary mucin). for each glycoprotein studied, gel filtration of its desialylated derivative gave an apparent molecular weights much less than that expected just from removal of sialic acid. for th ... | 1978 | 356853 |
| human cell membrane components dominant in t cell lineage: identification and characterization of human tl-like antigens. | cell membrane components that contain beta 2-microglobulin were purified from cells of a human t cell-type leukemia cell line, hpb-all. they contained membrane components that have the same molecular size and the same subunit structure as hla(a,b,c) antigens but are separable from the typical beta 2-microglobulin-containing cell membrane components, i.e., the hla (a,b,c) antigens, by xenoantibody reagents. a sensitive radioimmunoassay was constructed for detection of the t cell membrane componen ... | 1979 | 387877 |
| scanning electron microscope observations of microvascular anastomosis in the rat carotid artery. | microvascular anastomosis is gaining increasing significance in the field of replantation and reconstructive surgery. although traumatic interference is minimized by microsurgery, thrombotic occlusions remain the major reason for clinical failure. with the improvement of suturing technique studies were directed towards the causes of failure using light and scanning electron microscopy. our study was focussed on the latter aspect. the left common carotid artery of 55 albino rats was transsected ... | 1979 | 387900 |
| human plasma angiotensinogen: a review of purification procedures. | the current status of the purification and characterization of human angiotensinogen is reviewed. one problem encountered in the past has been the copurification of a protein with similar porperties. this protein has tentatively been designated alanine-protein. an efficient separation of angiotensinogen and alanine-protein was obtained on a zinc chelate column. alanine-protein has been purified and its amino acid and carbohydrate composition determined. the cooh-terminal amino acid and the nh2-t ... | 1979 | 390363 |
| mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis. | the effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. the data are discussed. | 1977 | 404520 |
| connective tissue composition of aortas from non-human primates. a comparative study. | connective tissue composition of aortas from several non-human primate species has been studied in an effort to relate collagen, elastin, ang glycosaminoglycan (gag) content to species susceptibility to atherosclerosis. among the species studied the baboon contained the highest content of gag in the aorta. while the distribution of individual gag varied from species to species, heparan sulfate (hs) was the highest gag in aortas from most of the species. the ratio of hs to chondroitin sulfates (c ... | 1978 | 415748 |
| prostaglandin (pg) analysis in urine of humans and rats by different radioimmunoassays: effect on pg-excretion by pg-synthetase inhibitors, laparotomy and furosemide. | the radioimmunological (ria) determination of prostaglandin (pg) e2 and of pgf2alpha in urine of humans and rats is described in detail. after extraction and chromatography pge2 was determined by using a pge specific antibody or by using either pgb or pgf2alpha specific antibodies after the respective conversion procedures. the three different ria procedures were compared to each other. pgf2alpha was determined by a specific antibody to pgf2alpha. basal excretion of pge2 and of pgf2alpha in heal ... | 1978 | 416466 |
| helical structure of the human umbilical cord. | the helical structure of the human umbilical cord has been studied on 528 full-term cords from normal deliveries, 18 cords from aborted and developmentally normal fetuses with a cr length of 1.2-19.5 cm, 10 cords from monozygotic twins. in order to resolve the discrepancy in the nomenclature of the twist direction, a method has been suggested which takes into account the direction to which the fetus must have rotated to produce the twist. the incidence of the right helical pattern was 64.58%, of ... | 1979 | 419931 |
| lesions of the myofibril in myopathic and normal tissue from seven striated muscles. experimental myopathy of isometric activity produced by phencyclidine and restraint. | | 1979 | 419941 |
| stability of estrogen receptors in frozen human breast tumor tissue. | the effect of freezing on the stability of the estrogen receptors in human breast tumors was measured. portions of three tumors kept frozen for 3 days after removal from the patients were analyzed by the sucrose density gradient method. the initial measurements demonstrated positive receptor values. the remaining portions were kept frozen for 30 days, and the receptor values were reevaluated. the 8s receptor was 80% destroyed under these freezing conditions. the 4s receptor was found to be more ... | 1979 | 427754 |
| contribution of adrenal medulla, spleen and lymph, to the plasma levels of dopamine beta-hydroxylase and catecholamines induced by hemorrhagic hypotension in dogs. | | 1979 | 438992 |
| the effect of some anti-rheumatic agents on tuberculin pleurisy in the guinea-pig [proceedings]. | | 1979 | 497564 |
| 2,3,7,8-tetrachlorodibenzo-p-dioxin: covalent binding of reactive metabolic intermediates principally to protein in vitro. | 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is metabolized by the mouse liver cytochrome p-450-mediated monooxygenase system to reactive intermediates which bind 'covalently' to cellular macromolecules. although very difficult to quantitate, the presumably covalent binding to microsomal protein occurs between 120 and 2,640 times more readily than binding to deproteinized dna in the in vitro reaction. because of the extremely high rate of binding to protein rather than to dna, it is visualized tha ... | 1979 | 515166 |
| [response of certain laboratory animals to being fed an ocean fish, the ruvette]. | | 1979 | 516605 |
| [dry adapting additive and its use in dairy products for approximating the composition of human milk]. | the paper concerns a procedure for a new product, dry adapting additive (daa), designed for manufacture of liquid substitutes of breast milk under industrial conditions. the chemical composition of adapted milk mixtures is compared to that of breast milk. procedures for adapted mixtures to be manufactured at city milk kitchens, food concentrate factories and under domestic conditions have been developed, with the mixtures being widely tried on clinical basis. | 1979 | 516610 |
| [ontogenesis of the entorhinal region of the human cerebral cortex]. | the ontogenesis of the entorhinal region of the human brain was studied on a series of continuous frontal sections of the brain in 13 pre- and postnatal ages. the sections were stained with crezyl violet. use was made of the quantitative methods. the study revealed some peculiarities in the ontogenetic development of certain subregions and areas of the entorhinal cortex of the human brain. peculiar of the development of the human antorhinal region in the second half of pregnancy is appearance of ... | 1979 | 525118 |
| the effects of sudden airway hypercapnia on the initiation of exercise hyperpnoea in man. | 1. in three healthy individuals, the first breath of cycle ergometer exercise was characterized by increases of minute ventilation (ve) and pulmonary capillary co2 output (vco2), with little change of end-tidal pco2, suggesting a concomitant increase of pulmonary blood flow (q) and preservation of v/q status. functional residual capacity fell, depleting lung gas stores of o2 and co2. 2. the following hypothesis purporting to account for the initiation of exercise hyperpnoea was examined (filley, ... | 1979 | 529086 |
| time-course of changes in baroreflex sensitivity during the development of renovascular hypertension in rats [proceedings]. | | 1979 | 529094 |
| effects of acetaminophen on normal human peripheral blood lymphocytes: enhancement of mitogen- and antigen-stimulated incorporation of tritiated thymidine. | this report describes hitherto unrecognized immunoenhancing properties of acetaminophen on cultured human lymphocytes. the addition of acetaminophen (2.5--300 micrograms/ml) significantly enhanced mitogen-induced blastogenesis. the stimulation of cells by candida albicans, from individuals who were skin-test positive for antigen and two-way responses of mixed lymphocytes, were similarly augmented. cells stimulated in the presence of acetaminophen were comparably enhanced in cultures lasting for ... | 1979 | 535186 |
| an evaluation of the bovine -- onchocerca gibsoni, onchocerca gutturosa model as a tertiary screen for drugs against onchocerca volvulus in man. | in this trial suramin, diethylcarbamazine, trichlorphon, levamisole, mebendazole, melarsonyl potassiu, hoechst 33258 and tinidazole were administered to cattle infected with o. gibsoni and o. gutturosa to determine the usefulness of this screen in predicting the effect of drugs in man against. o. volvulus except for melarsonyl potassium which was macrofilarticidal against o. gutturosa but not o. gibsoni when cattle were slaughtered 6 weeks after treatment. it was concluded that cattle infected w ... | 1979 | 538819 |
| identification of a new allele of es-i segregating in an inbred strain of mice. | a new allele of es-1, designated es-1e, has been identified in the mouse. this allele was discovered segregating among the progeny of a strain dba/2j male and is apparently the result of a spontaneous mutation within this strain. genetic analyses have shown that this mutation is heritable and, further, that both heterozygous and homozygous progeny are viable and fertile. to date, no discernible deleterious effects have been identified as associated with this mutation. | 1979 | 540008 |
| identification of a new allele of es-i segregating in an inbred strain of mice. | a new allele of es-1, designated es-1e, has been identified in the mouse. this allele was discovered segregating among the progeny of a strain dba/2j male and is apparently the result of a spontaneous mutation within this strain. genetic analyses have shown that this mutation is heritable and, further, that both heterozygous and homozygous progeny are viable and fertile. to date, no discernible deleterious effects have been identified as associated with this mutation. | 1979 | 540008 |
| effect of sodium hydroxide upon protein binding to filter paper disks and its significance in the determination of protein in colorimetric and radioisotopic assays. | | 1979 | 543545 |
| biochemical properties and drug sensitivity of klebsiella species isolated in lusaka. | | 1979 | 544262 |
| effect of dietary fats and triiodothyronine administration on the lipid components of serum and tissues in the rat. | twelve groups of rats were included in this study. six groups (3 males and 3 females) received high fat diets containing 20% of either peanut oil, maize oil or lard. the other six groups received the same diets plus triiodothyronine. triiodothyronine t3 added to diets containing peanut oil caused slight increase in total serum lipids in female rats, while in male rats serum total lipids were increased about 20-fold. t3 administration caused almost no change in aortic total and all lipid fraction ... | 1979 | 549273 |
| abrupt (sharp cut) type sensorineural hearing loss--a human temporal bone study--. | histopathology of a case of bilateral sensorineural hearing loss of abrupt (sharp cut) type is reported. while there was a 45 db gap in threshold between 1,000 hz and 2,000 hz bilaterally, the patient had a good hearing at 1,000 hz and lower frequencies. the patient was suffering from takayasu's arteritis. major histopathological findings were as follows: almost complete loss of the outer hair cells from the basal end to 12 mm area in the left cochlea (length: 30.5 mm) and 13 mm in the right (le ... | 1979 | 549560 |
| the role of lipids in the serum lipoproteins as inhibitors of hemagglutination by japanese encephalitis virus. | | 1976 | 1011379 |
| relationship between antiinflamatory and antiproteolytic properties of substituted oxothiazolylacetic acids. | | 1976 | 1026952 |
| alteration of colony-stimulating factor output, endotoxemia, and granulopoiesis in cyclic neutropenia. | cellular and humoral factors involved in the regulation of granulopoiesis were evaluated in two patients with cyclic neutropenia by utilizing the agar-gel marrow culture technique to serially study marrow granulocytic colony-forming capacity (cfc) and the urinary output of colony-stimulating factor (csf). csf output varied inversely with peripheral neutrophil counts and directly with monocyte counts and evidence for infection (endotoxemia and/or staphylococcal abscesses). following autologous in ... | 1976 | 1087533 |
| rejoining of radiation-induced single-strand breaks in deoxyribonucleic acid of escherichia coli: effect of phenethyl alcohol. | single-strand breaks in deoxyribonucleic acid of escherichia coli b/r cells exposed to 20 krads of gamma radiation could be rejoined by incubation of irradiated cells in growth medium. in the presence of 0.25% phenethyl alcohol, this repair was completely inhibited although deoxyribonucleic acid and protein syntheses were suppressed only partially. | 1975 | 1090577 |
| macrophage-lymphocyte clustering in rheumatoid arthritis. | the cells in synovial fluid from patients with rheumatoid arthritis contain a small percentage of macrophages. such macrophages were isolated and cultured alone and with homologous and heterologous lymphocytes for 24 hours, in an attempt to identify possible contact between living lymphocytes and macrophages. such contact was found, with clustering of lymphocytes around macrophages, and was particularly well shown by scanning electron microscopy. | 1975 | 1092274 |
| effects of bretylium on rat cardiac muscle: the electrophysiological effects and its uptake and binding in normal and immunosympathectomized rat hearts. | bretylium produced electrophysiological effects on both rat atrium and ventricle in vitro at concentrations ranging from 2 times 10- minus 5 to 10- minus three m. those effects included lengthening of action potential duration and effective refractory period; increasing effective refractory period/action potential duration; decreasing dv/dt of phase zero of the action potential and suppressing the action potential amplitude and overshoot. these effects, which could serve as a basis for the antia ... | 1975 | 1133764 |
| proceedings: cell-wall composition of aerobic cutaneous "diphtherios" organisms. | | 1975 | 1142405 |
| cyanogen condensations as a route to 3-amino-2-imino-1,3-benzothiazin-4-ones with cns depressant potential. | seven new 3-amino-2-imino-1,3-benzothiazin-4-ones, prepared from the condensation of cyanogen and 2-mercaptobenzhydrazides, were evaluated in a neuropharmacological mouse profile. cns depression was observed in several members of the class. | 1975 | 1151723 |
| proceedings: the effect of warming and cooling the hypothalamus, or intracarotid injections of cold saline, on thermoregulatory behaviour in sheep. | | 1975 | 1151866 |
| hl-a w27 in psoriatic arthropathy. | forty subjects with psoriatic arthritis (pa) underwent hl-a tissue typing. hl-a w27 was significantly increased in psoriatic spondylitis (35%), whereas statistical significance was not reached in patients with peripheral arthritis alone, although w27 was present in a frequency greater than in controls. psoriatic spondylitis (often asymptomatic) occurred in 57% (23 of 40) of our pa patients. of interest, psoriatic spondylitis was more often w27 negative than w27 positive; nevertheless, w27-positi ... | 1975 | 1169069 |
| comparative in vivo distribution of opiate agonists and antagonists by means of double isotope techniques. | | 1975 | 1196002 |
| common morphogenetic aspects of various organotypic microvascular patterns. | | 1975 | 1214601 |
| [salmonellosis carrier state]. | | 1975 | 1214656 |
| [cortical organisation and the experience: electrophysiological properties of cells of the visual cortex and the visual experience]. | | 1975 | 1230912 |
| [a cytophotometric and karyometric study of the granular cells of the rat brain. i. granular cells of the cochlear complex and cerebellum]. | two cell types can be distinguished in granular cells of the chochlear complex of the rat by the form of their processes and the structure of the nuclear chromatin. it is shown cytophotometrically that the majority of the granular cells of the cochlear complex and in the cerebellar cortex are diploid. however, some cells contain dna amount close to tetraploid. some correlation between the size of the nucleus and its dna amount was discovered both in the cerebellar cortex and in the cochlear comp ... | 1975 | 1231101 |
| [characteristics of erythrocyte membrane permeability for potassium ions in rats with familial spontaneous hypertension]. | the kinetics of 42k influx into the erythrocytes was studied in spontaneously hypertensive rats (shr) during the prehypertensive and early hypertensive stages (aged 10 weeks), as well as in wistar and sprague-dawley rats of the same age. the shr displayed a significantly slower enhancement of the activity in the erythrocytes than in the wistar and sprageu-dawley rats, which indecates a higher level of passive permeability of the erythrocytic membrane for potassium ions and an enhanced turnover o ... | 1975 | 1235139 |
| the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens. | counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ... | 1976 | 1262695 |
| attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization. | four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ... | 1976 | 1262709 |
| isolation of mycoplasmas from the respiratory tract of horses in australia. | mycoplasmas were isolated from two of 43 nasal swabs taken from live horses, and from one of 28 tracheal swabs taken from slaughtered horses. the slaughtered horse that yielded mycoplasmas had no gross pathological changes in the respiratory tract, but the nasal isolations were made from horses with rhinitis. the three mycoplasmas could be distinguished by cultural characteristics, and probably they represent three different species. | 1976 | 1265985 |
| regeneration of an adult peripheral nerve preparation in culture. | the methods used to maintain the vagus nerve from the adult rat in culture and how regeneration is studied in this preparation are described. a hypothesis is presented on the triggering of the cell body reaction. it is suggested that this reaction is initiated by proteins synthesized in nonneuronal cells at the site of a nerve lesion. these proteins, referred to as regenerins, reach the nerve cell body by retrograde axonal transport, where they initiate the regeneration process. | 1992 | 1282333 |
| electrophoretic analysis of heterogeneous lipopolysaccharides from various strains of vibrio vulnificus biotypes 1 and 2 by silver staining and immunoblotting. | lipopolysaccharides (lps) of 11 strains of vibrio vulnificus biotypes 1 and 2, isolated from an eel farm, and of 10 reference strains, were examined by sds-polyacrylamide gel electrophoresis coupled with silver staining and immunoblotting. lps samples were obtained from whole-cell lysates, outer membrane fragments, and extracellular products. by silver staining, only a diffuse band of low-molecular weight could be visualized in all cases except for a biotype 1 strain isolated from water. however ... | 1992 | 1283727 |
| reversal of hypotension induced by vibrio vulnificus lipopolysaccharide in the rat by inhibition of nitric oxide synthase. | intravenous infusion of vibrio vulnificus lipopolysaccharide (lps) (1 mg/kg body wt) in rats caused a dramatic drop in mean arterial pressure within 10 min and a further decline in mean arterial pressure and heart rate which lead to death between 25 and 70 min. rats treated with lps followed 10 min later by the intravenous infusion of ng-monomethyl-l-arginine (l-nmma, 20 mg/kg body wt) showed an initial drop in mean arterial pressure owing to the lps infusion, followed by a transient rise in mea ... | 1992 | 1284317 |
| aspergillus flavus wound infection following repair of a ruptured duodenum in a non-immunocompromised host. | aspergillus flavus is generally considered to be an opportunistic organism, rarely causing clinical infections in the immunocompetent host. we present a case of a 79-year-old man without history of immunocompromise who developed a severe aspergillus wound infection in an open wound following repair of a traumatic duodenal perforation. despite aggressive treatment, this invasive infection contributed significantly to his eventual demise. | 1992 | 1287817 |
| role of iron in the virulence of vibrio vulnificus isolated from cuddalore coastal waters (india). | v. vulnificus strains isolated from different sources of cuddalore coastal waters were tested for their virulence activity through their ld50 values in mice. as infections of v. vulnificus have been correlated with pre-existing liver disease and hemochromatosis, the role of iron on virulence was determined using. iron overloaded mice. the ld50 was in the range of 10(4)-10(7) cells in normal mice but 10(1)-10(2) cells in iron-injected mice, thus providing evidence that iron may play a major role ... | 1992 | 1291464 |
| expression and release of neuroregulators during development: monoamines and neuropeptides. | the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ... | 1992 | 1306802 |
| inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder. | gamma-amino-butyric acid (gaba) is an established inhibitory neurotransmitter in the central nervous system (cns) and it has also been identified in the bladder. we have investigated in the rabbit the effect of gaba on detrusor activity. rabbit detrusor muscle strips were made to contract by electrical stimulation of their autonomic nerves or by the addition of carbachol. the addition of gaba caused substantial inhibition of muscle contraction. gaba acts on 2 classes of receptors-gabaa and gabab ... | 1992 | 1310630 |
| a serosurvey of pathogens associated with shellfish: prevalence of antibodies to vibrio species and norwalk virus in the chesapeake bay region. | recent concerns regarding the safety of shellfish consumption have focused on the risk posed by naturally occurring marine bacteria such as vibrio species and by viruses such as norwalk and related agents. despite the widespread environmental presence of vibrio species in the chesapeake bay, the rate of reported infections remains low; there have also been no reports of major norwalk outbreaks associated with shellfish in this area. as infections with these agents may not always be recognized be ... | 1992 | 1312771 |
| kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal met-enkephalin release. | the possible opioid control through delta, mu and kappa receptors of the spinal release of met-enkephalin-like material (melm) was investigated in halothane-anaesthetized rats. the intrathecal perfusion of the delta agonist dtlet (10 microm) or the mu agonist dago (10 microm) resulted in a marked inhibition of melm release, which could be prevented by the selective antagonists naltrindole and naloxone, respectively. although the kappa agonist u 50488 h (10 microm) was inactive per se, it complet ... | 1992 | 1317026 |
| modulation of neutrophil functions by activated platelet release factors. | platelets activated with physiological agonists, such as thrombin, adp, or collagen, released products able to modulate neutrophil functions. in particular, platelet supernatant contained an inhibitor of superoxide anion generation induced by phorbol ester and a chemotactic factor for human neutrophils. the proteolytic digestion of platelet supernatant completely abrogated chemotactic activity without interfering with the inhibitory effect, indicating the presence of different molecules involved ... | 1992 | 1317360 |
| gap-43 mrna localization in the rat hippocampus ca3 field. | gene expression of the axonal growth-associated protein, gap-43, has been studied in the adult rat brain by in situ hybridization histochemistry. this protein is synthesized at high levels in neuronal somata in immature and regenerating neurons, but after establishment of mature synaptic relations its synthesis generally declines sharply, thus providing a marker denoting propensity for exhibiting synaptic plasticity. detailed examination of the distribution of mrna for gap-43 in rat hippocampus ... | 1992 | 1317499 |
| some biochemical changes in mouse after in-vivo irradiation of pancreas with ultrasound. | 875 khz continuous wave of ultrasound at 2.5 w/cm2 intensity revealed certain biochemical and enzymological changes in mouse pancreas and liver following the irradiation of pancreas in-vivo for a total of 300 seconds spread over five days. the sacrifice of the animals was carried out on day 0, day 1, day 5 and day 10. blood glucose was reduced significantly with concomitant increase in liver glycogen. glucose-6-phosphatase in liver was decreased significantly while glycogen phosphorylase showed ... | 1992 | 1319155 |
| experience of six patients with vibrio vulnificus septicemia. | vibrio vulnificus, a halophilic lactose fermenting vibrio, is a virulent pathogen for men and is frequently associated with overwhelming infections of areas other than the gastrointestinal tract. we encountered six cases of vibrio vulnificus septicemia in veterans general hospital-taipei over the past four years. all were admitted through the emergency room and presented with urgent conditions on arrival. the patients also demonstrated preexisting liver function impairment (either hepatic diseas ... | 1992 | 1320993 |
| effects of temperature abuse on survival of vibrio vulnificus in oysters. | opaque and translucent morphotypes of a tnphoa-containing strain of vibrio vulnificus were fed to oysters, which were subsequently stored at temperatures ranging from 0.5 to 22 degrees c for 10 days. samples of oysters were homogenized and plated at intervals to determine the cell density of v. vulnificus and total aerobic population of bacteria present. at all temperatures, the numbers of v. vulnificus (both morphotypes) declined over the 10-day study period. the same observation was made with ... | 1992 | 1332610 |
| protein phosphatase 2a is a specific protamine-kinase-inactivating phosphatase. | purified preparations of a protamine protein kinase from bovine kidney cytosol [damuni, amick & sneed (1989) j. biol. chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2a1 and protein phosphatase 2a2. these protein phosphatase 2a-mediated inactivations of the protamine kinase were unaffected by highly purified preparations of inhibitor 2, but were prevented when the incubations were performed in the presence of 100 nm microcystin-lr ... | 1992 | 1332680 |