| relationships between intracellular proteolytic activity and protein turnover in bacillus megaterium. | when incubated in a sporulation medium, the sporogenous strains of bacillus megaterium degrade proteins at a rate of 4-10% x h-1. the maximal rate of protein turnover is reached after 3-4 hrs at the time of development of forespores and then decreases again. the rate of protein turnover in the asporogenous strain decreases steadily under similar conditions from 3-8% x h-1 at the beginning of incubation to 1% x h-1 after 5-6 hrs in the sporulation medium. the rate of degradation of proteins in vi ... | 1977 | 99935 |
| effect of a staphylococcin on neisseria gonorrhoeae. | phage group 2 staphylococcal strain ut0002 contains a large 56s virulence plasmid with genes that code for both exfoliative toxin and a specific staphylococcin termed bac r(1). four penicillinase-producing strains and three penicillin-susceptible strains of neisseria gonorrhoeae were killed by bac r(1). after 30 min of growth of the penicillin-resistant tr1 strain in 62.5 arbitrary units of bac r(1) per ml, loss of viability was approximately 90%, and, after 5 h, an approximately 99.99% loss of ... | 1978 | 100049 |
| uk-18892, a new aminoglycoside: an in vitro study. | uk-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin a structurally related to amikacin. it was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. the spectrum and degree of activity of uk-18892 were similar to those of amikacin, and differences were relatively minor. uk-18892 was about twice as active as amikacin against gentamicin-susceptible strains of pseudomonas aeruginosa. both amikacin and uk-18892 were equally ac ... | 1978 | 100050 |
| modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s. | a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. the mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. the resistan ... | 1978 | 100051 |
| ultraviolet light-induction and photoreactivation of thymine dimers in a cyanobacterium, anacystis nidulans. | partially photoreactivable mutant of anacystis nidulans demonstrates partial photorepair of thymine dimers. the wild type which is completely photoreactivable at the conditions studied shows higher level of thymine dimer photolysis. | 1978 | 100072 |
| [origin of a mitogrenic factor for cultivated macrophages (imf: inflammatory mitogenic factor) found in exudates of non-specific acute inflammation]. | the mitogenic activity of inflammatory exudate obtained from irradiated rats is reduced. after transfer of bone marrow syngeneic cells into irradiated rats this mitogenic activity is further decreased, while after transfer of thymic cells it is increased. it is postulated that the mitogenic activity of inflammatory exudate could be related to thymic cells and that t lymphocytes may be involved in non specific-inflammatory reactions. | 1978 | 100246 |
| influences of physical conditioning and deconditioning on coronary vasculature of dogs. | to investigate the effects of physical conditioning and deconditioning on the coronary vasculature, eight dogs were exercised by treadmill running. five dogs were deconditioned by confinement in cages following the conditioning period. a technique was developed and validated for measuring circumflex coronary artery diameter from magnified projections of standardized coronary angiograms. myocardial capillary density, perimeter, and basement membrane thickness were determined from electron microsc ... | 1978 | 101496 |
| incorporation of amino acids by isolated submitochondrial fractions of lactating goat mammary gland in vitro. | incorporation of amino acids by mitochondria and its subfractions from mammary gland of the goat during lactation was studied in vitro. assessment of distribution of radioactivity incorporated by intact mitochondria into its subfractions revealed maximum specific activity in the inner membrane. during lactation the inner membrane of mitochondria exhibited further stimulation in such incorporation. matrix was the next active fraction whereas outer membrane and peripheral space had negligible radi ... | 1978 | 101564 |
| dominant constitutive mutations in malt, the positive regulator gene of the maltose regulon in escherichia coli. | | 1978 | 101676 |
| studies on virus-inhibiting substances of bacterial origin. iv. antiviral substances extractable from streptococcus faecalis: its in vivo effect. | | 1978 | 101714 |
| [effect of reserpine on the formation of 9,10-dimethyl-1,2-benzanthracene induced tumors in pinealectomized and thymectomized rats]. | after reserpine treatment the incidence of dimethylbenzanthracene-induced tumors was found to be significantly higher in pinealectomized rats than in intact or thymectomized ones. a very high rate of dmba-leukemia was observed in immune-deficient pinealectomized rats after reserpine administration. it is therefore suggested that the neuroendocrine disturbances due to removal of the pineal gland in the newborn animals, are latent and become evident after reserpine administration as reflected in a ... | 1978 | 101920 |
| a receptor for polymerized human and chimpanzee albumins on hepatitis b virus particles co-occurring with hbeag. | a receptor for polymerized human serum albumin was demonstrated on dane particles as well as on 20-nm hepatitis b surface antigen particles, isolated from asymptomatic carriers of hepatitis b virus who were positive for hbeag. in contrast, such receptor was not born by 20-nm hepatitis b surface antigen particles obtained from carriers positive for antibody to hbeag. hepatitis b surface antigen particles with the receptor were heavier than those without, and when treated with pronase, they became ... | 1979 | 103774 |
| dietary lactose and the aetiology of human small-intestinal hypolactasia. | | 1978 | 103781 |
| on the interactions of yersinia strains and cell cultures. | comparative investigations were carried out on the dynamics of invasion of cell cultures by strains yersinia pestis ev and yersinia pseudotuberculosis treated vitally with petroleum ether. it was established that the invasiveness of the strains studied was related to the presence of chemical structures of the bacterial surface sensitive to the action of either and whose synthesis was temperature dependent. the penetration and initial stages of intracellular multiplication of the yersinia were ac ... | 1978 | 104477 |
| [study of the initial stages of microorganism growth and development for assessing the bactericidal action of chemical substances]. | | 1979 | 104902 |
| transcription and translation in a pleiotropic streptomycin-resistant mutant of escherichia coli. | the role of the ribosomal protein s12 (streptomycin protein) in ribosome function and in other metabolic processes in the cell has been investigated. a spontaneous streptomycin-resistant strain of escherichia coli (sm3) carrying a mutation in the rpsl gene is deficient in its ability to induce the synthesis of the enzyme bets-galactosidase. it was demonstrated that the reduced rate of enzyme synthesis results from deficiencies in both the transcription of the lactose operon and translation of th ... | 1979 | 104958 |
| [acute enteritis with "new" pathogens. yersinia infections (author's transl)]. | infections of the intestinal tract with yersinia enterocolitica and yersinia pseudotuberculosis are known the world over. post-infection reactions like arthritis, erythema nodosum, erythema multiforme, scarlatiniform exanthemata and septicemic types deserve particular clinical attention. the clinical importance of enteric yersinioses has been shown in studies with the identification of significant antibody titers against yersinia enterocolitis and yersinia pseudotuberculosis in 6.71 and 4.58% re ... | 1979 | 105284 |
| mutagenic effect of 7, 12-dimethylbenz[a]anthracene-epidioxide on salmonella typhimurium. | | 1979 | 106234 |
| [chronic oral cadmium load in sheep. toxicological and pathomorphological studies]. | | 1978 | 106587 |
| inhibition of neisseria gonorrhoeae by normal human saliva. | saliva was found to be a powerful and specific inhibitor of neisseria gonorrhoeae. although 28 other species of bacteria were tested, including neisseria meningitidis, neisseria pharyngis var flava, neisseria lactamica, and neisseria catarrhalis, we failed to find any others sensitive to saliva under similar conditions. the physical properties of the inhibitory substance indicated that it might be salivary alpha-amylase. to test this hypothesis alpha-amylase was extracted from saliva and was sho ... | 1979 | 106919 |
| liver transplantation. | | 1979 | 107000 |
| dietary protein, aryl hydrocarbon hydroxylase and chemical carcinogenesis in rats. | | 1979 | 107295 |
| effects of dietary composition on somatomedin activity in growing rats. | | 1979 | 107298 |
| [preparation of extracellular ribonuclease from bacillus subtilis]. | the paper describes a method for isolating alkaline ribonuclease from the culture liquid bacillus subtilis kp 349 which involved: submerged cultivation of the producer on complex and synthetic nutrient media with optimized rnase activity, acid treatment of the total culture liquid, and filtration through perlite. further treatment may include either spray drying of the culture liquid filtrate or its concentration in a vacuum evaporator, dialysis of the concentrate against distilled water, and d ... | 1978 | 107517 |
| frequency and fate of human renal allografts contaminated prior to transplantation. | bacterial cultures were done from donor ureter and/or graft perfusion fluid on 92 of 112 patients who had renal transplantations during 1977. three samples of perfusion fluid and 14 samples of donor ureter contained bacteria. in nine cases there was a gram-positive organism, and in 10 cases a gram-negative rod was (among) the contaminant(s). there was no difference in the rate of graft survival, patient survival, or in the frequency of major postoperative complications between the two groups. on ... | 1979 | 107605 |
| uv versus chemical polymerization of glycol methacrylate (gma) in enzyme histochemistry. | the influence of the mode of polymerization of gma on the enzyme activities of differently fixed rat livers was studied. it was found that with increasing time of uv-polymerization several enzyme activities were inhibited whereas chemical polymerization was comparatively less harmful. the histochemical reactivity of substrates such as glycogen was not impaired by the mode of polymerization, which is in contrast to the increased basophilia of dna and rna after uv-polymerization. | 1978 | 107707 |
| constant and flickering light stimulations produce similar effects on rna content in visual cells. | adult male rats were illuminated for 2 h with a constant or flickering light of 40 lx intensity; frequency of flickering was 2 hz. by means of two-wave-length visible cytospectrophotometry of gallocyanin-stained sections, it was shown that the light stimulation resulted in a marked rna accumulation in retina ganglion neurons and in the neurons of all the cell layers of visual cortex (with the only exception of the layer vi). in the cells of perineuronal glia, a decrease of the rna content per ce ... | 1978 | 107713 |
| albumin-coated amberlite xad-7 resin for hemoperfusion in acute liver failure. part i: adsorption studies. | platelets adhere to most foreign surfaces. as a result, polymers and albumin have been suggested as possible coatings to improve the blood compatibility of such surfaces. amberlite xad-7 has a high affinity for human serum albumin (hsa) and several protein-bound toxic metabolites. in the present study it is shown that hsa can be tightly bound to amberlite xad-7 without the use of chemical coupling agents. optimal binding was achieved at ph 5.0 and the adsorption conforms to langmuir's isotherm. ... | 1979 | 107929 |
| spinal cord evaluation by cortical evoked responses. | in ten monkeys, selective segmental lesions of the dorsal columns at the upper thoracic and middle cervical levels resulted in almost total attenuation of the cortical evoked potential responses to peripheral nerve stimulation. conversely isolated segmental dorsal column preservation showed intact transmission of the evoked responses at rostral spinal cord, nucleus ventralis posterior lateralis, and cortical levels. responses recorded from the intralaminar thalamic nuclei in the region of nucleu ... | 1979 | 107931 |
| localization of prostaglandin synthetase in chicken epiphyseal cartilage. | prostaglandin synthetase activity in high-speed particulate fractions of chick epiphyseal cartilage has been characterized with respect to cofactor requirements, ph optimum, buffer-ion effects, types of prostaglandins formed, and the distribution of prostaglandin synthetase activity in zones of the epiphyseal plate. direct homogenization of cartilage was found to be more efficacious than releasing chondrocytes by enzymatic digestion for preparation of prostaglandin synthetase, a homogenization t ... | 1978 | 108004 |
| [in vitro biosynthesis of beta-lipotropin in brain tissue]. | we have recently developed methods to identify biosynthetized beta-endorphin and beta-lipotropin (beta-lph) following incubation of rat pars intermedia with radioactive amino acids. we used the same approach for rat brain tissue. in the striatum we found a peptide similar to beta-lph while its identification in hypothalamus was less positive. this is the first demonstration of such biosynthesis and it could well be an important step in determining the biosynthetic patterns of cerebral endorphins ... | 1979 | 108023 |
| immunoelectrophoretic studies on human small intestinal brush border proteins. a quantitative study of brush border enzymes from single small intestinal biopsies. | a method for measuring brush border membrane enzymes from small intestinal biopsies by crossed immunoelectrophoresis is presented. the use of a brush border specific antiserum made isolation of the brush border membrane before analysis unnecessary. this prevented loss of material which, together with inactivation of enzymes, was a limiting factor in previous studies of brush border enzymes from peroral biopsies. in 58 biopsies from patients without gastrointestinal disorders a close correlation ... | 1979 | 108036 |
| epilepsy, attentiveness and consciousness: recent contributions from behavioral and physiological investigations. a summary and commentary. | | 1978 | 108075 |
| sexual behavior and hormone levels during the menstrual cycles of rhesus monkeys. | | 1978 | 108191 |
| bacterial fusion assayed by a prophage complementation test. | in previous studies of bacterial protoplast fusion, only the frequencies of cell wall regeneration and of bacterial recombination were determined. in this work the frequency of the heterozygous fusion products is measured by prophage complementation. two multiply marked nonsuppressing strains of bacillus subtilis, each lysogenic for a different sus mutant of the phage phi 105, were induced by mitomycin c, protoplasted, fused, and, after dilution in hypertonic broth, incubated until plating with ... | 1979 | 108245 |
| [vaccinations. ii. indicated under special conditions]. | | 1979 | 108566 |
| [on the antimicrobial activity of propolis and propolis constituents (author's transl)]. | after a survey of the literature on the antimicrobial activity of the bee product propolis, the authors discuss their own findings as compared to the chemotherapeutical agents streptomycin, oxytetracycline, chloramphenicol, nystatin, griseofulvin and sulphamerazine. according to the results obtained by testing 25 isolated constituents on bacillus subtilis, staphylococcus aureus, candida albicans and trichophyton mentagrophytes, the antimicrobial properties of this mixture of natural substances a ... | 1979 | 108687 |
| sex differences following pharmacological manipulation of the cholinergic system by dfp and pilocarpine. | | 1979 | 108719 |
| dietary modification of amphetamine stereotyped behaviour: the action of tryptophan, methionine, and lysine. | rats fed diets high in tryptophan, methionine, and tryptophan plus methionine or lysine were subsequently injected with 10 mg/kg d-amphetamine. the amount of amphetamine-induced stereotyped behaviour observed varied as a function of the dietary addition, with methionine showing the greatest difference to controls, and lysine the least. whole brain catecholamine levels and 5-hydroxytryptamine levels also showed amino acid-specific changes. | 1979 | 108724 |
| effect of listeria monocytogenes lipids on the course of infections with some gram-negative bacilli in mice. | the effect of listeria monocytogenes lipids on the course of infections with salmonella enteritidis, yersinia pseudotuberculosis, pseudomonas aeruginosa and klebsiella pneumoniae was studied in mice. the lipids were extracted with chloroform and methanol and used in various doses before and after infection with the bacilli. the lipids significantly increased mouse resistance toward the examined bacteria. the protective effect depended, to a large extent on the applied dose of lipids and its timi ... | 1979 | 109064 |
| lethal effect of protamine and histone on competent bacillus subtilis cells. inhibition of genetic transformation by protamine in sublethal concentration. | under experimental conditions of genetic transformation, protamine and total histone were bactericidal for bacillus subtilis cells. the abilities to cause lethality were very similar for both, either protamine or histone, with no antagonistic effects amongst these natural polycations. with both basic proteins acting simultaneously the enhancement was higher than a summation of the separate lethal effects. sublethal concentration of protamine added at the beginning of transformation time, produce ... | 1979 | 111002 |
| hallucinogen-induced rotational behavior in rats. | | 1979 | 111284 |
| evaluation of high-protein supplements in children with protein energy malnutrition. | the present study was designed to test the comparative efficacy of cow's milk, a protein, vitamin and mineral mixture (pvm) and soybean textured vegetable protein (somos) as supplements to maize meal porridge in the dietary treatment of children with protein energy malnutrition (pem). each diet was designed to provide approximately 480 kj/kg with 2 protein/kg from the test protein, and 1,8 g protein/kg from maize. response to treatment was measured by loss of oedema, subsequent weight gain, rate ... | 1979 | 111358 |
| [combined infection with yersinia pseudotuberculosis and mycobacterium tuberculosis as a rare cause of obstructive icterus]. | | 1979 | 112451 |
| serologic study of pasteurella aerogenes sp n. | the antigenic attributes of pasteurella aerogenes sp n were serologically compared with species of the genera actinobacillus and pasteurella. examination included the tube-agglutination and double-immunodiffusion techniques. the results indicated the possibility of serologically different strains of p aerogenes. antisera prepared from strains of p aerogenes also reacted well with antigens prepared from yersinia pseudotuberculosis (p pseudotuberculosis) and p pneumotropica. | 1979 | 112888 |
| [topography of soluble gliofibrillar protein (gfa) in aged human brain]. | a great variation was observed in the amount of soluble gfa depending on the brain area. large amounts were found in the chiasma and in the pons whereas the cortical grey matter was poor. it is suggested that soluble gfa represents a potentiality of defense of the nervous tissue. | 1979 | 113120 |
| spontaneous zinc deficiency in marmosets, saguinus mystax. | moustached marmosets, saguinus mystax, developed alopecia, skin lesions and general debilitation approximately 6 months after being brought into our laboratory. these lesions resembled the signs of zinc deficiency in pigs, rats and squirrel monkeys. the marmosets were fed a commercial monkey diet containing 150 parts per million zinc and about 100 g of apples and oranges per week. the addition of 40 parts per million zinc to the drinking water brought about improvement in hair coat and skin cond ... | 1979 | 117220 |
| [immunostimulating activity of the lipopolysaccharides of blue-green algae]. | the whole cells of blue-gree algae and lipopolysaccharides isolated from these cells were shown to stimulate the production of macro-(mainly) and microglobulin antibodies in rabbits. the macro- and microphage indices in rabbits increased significantly after the injection of lps isolated from blue-green algae 24--48 hours before infecting the animals with a virulent y. pseudotuberculosis strain. besides, the inhibiting action of this strain on the migration of phagocytes to the site of infection ... | 1979 | 117655 |
| [oculomotor reflex evoked by vibrassae stimulation in the cat]. | the oculomotor effects of vibrissae stimulation have been studied in the "encéphale isolé" non-anaesthetized cat. intracellular recording of lateral rectus motoneurones showed an excitatory projection via the ipsilateral infraorbital nerve to these motoneurones. the afferent fibers are type a alpha, recuited with a low threshold (0.2-0.5 ma) and convey information about vibrissae displacement. | 1979 | 120789 |
| relative fat-carbohydrate efficacy in parenteral nutritional support. | | 1978 | 122624 |
| relationship between ca-atpase activity and subunits of myosin in the myocardium of rats conditioned by swimming. | | 1975 | 125656 |
| stimulation of syngeneic and allogeneic lymphoid cells by tumour cells in vitro. | august and wistar rat lymph node cells were found to respond well to pha stimulation and in mixed lymphocyte culture, as determined by an increased incorporation of 3h-thymidine. august rat lymph node cells were also stimulated by incubation with irradiated syngeneic tumour cells. allogeneic wistar rat lymph node cells produced a larger response to the august tumour cells. the response of syngeneic and allogeneic lymph node cells was reduced by pretreating the tumour cells with a wistar anti-tum ... | 1975 | 126072 |
| [lactate dehydrogenase isoenzymes in cerebral cortex of young rats undernourished since birth]. | the developmental profile of the isoenzymes of lacticodehydrogenase of cerebral cortex, investigated by starch gel electrophoresis, is not retarded during neo and post-natal undernutrition, although hypothyroidism is known to do so. | 1975 | 126758 |
| effect of methysergide, a blocker of serotonin receptors, on plasma prolactin levels in lactating and ovariectomized rats. | the effect of methysergide (mes, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. mes caused significant increases in prolactin release in both animals. studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a decrease in the peripheral metabolism of prolactin. in vitro incubations of anterior pituitary fragments with mes failed to demonstrate any increase in prolactin release, suggesting ... | 1975 | 126860 |
| elementary particles in isolated rat liver and spleen nuclear membranes. | elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ... | 1975 | 126876 |
| effect of essential phospholipids on the properties of atpases of isolated rat liver plasma membranes of young and old animals. | "essential" phospholipids (epl), rich in dilinoleyl-phosphatidylcholine were given orally to young and 780-800 day-old rats. the double-labelled (14c/32p) dilinoleyl-phosphatidylcholine was incorporated in plasma membranes and the amounts incorporated into different organs investigated. old animals incorporated higher radioactivity than young. the 14c/32p ratio however decreased in comparison with the substance administered. the amount of (na+-k+)-atpase in rat liver plasma membranes of old anim ... | 1975 | 127894 |
| microautoradiographic study of cell proliferation in compensatory renal growth. | dna synthesis in the renal parenchyma was studied by electron microscopic autoradiography 48 and 72 hours after unilateral nephrectomy in mice and weanling rats. the proportion of labelled nuclei belonging to the epithelium, endothelium, interstitial areas, or circulating cells was evaluated. most of cells showing dna synthesis were epithelial but many belonged to stroma. all the nephron segments were found to participate in compensatory hyperplasia, with a greater contribution, however, of the ... | 1975 | 127941 |
| [vaccination strategy in influenza]. | the present paper deals with the conditions that influenza vaccines must comply with, their efficiency in terms of the route of administration, the major antigenic changes of influenza viruses, that has to be known from beforehand, a basic problem for the efficient control of a pandemic. vaccination must have in view reduction of the mortality and morbidity rate, a major criterion in establishing a programme for the prevention of influenza by vaccination. | 1975 | 128101 |
| [histological, histoenzymatic and biochemical study of the liver and small intestine of rats during short periods of starvation]. | the structure and the activity of acid phosphatase, beta-glucuronidase, alkaline phosphatase and atp-ase in the liver and small intestine of rats receiving for 20 days a one-time, fixed at a certain time (2 o'clock) feeding was studied morphologically in dynamics in 2, 6, 24 and 48 hours after the last feeding. furthermore, parallel with this the activity of acid phosphatase, beta-glucuronidase, alpha-glucosidase and beta-acetylglucosaminidase was determined in homogenates by biochemical methods ... | 1975 | 128202 |
| studies on in vitro carcinogenesis. i. autoradiographic and biochemical study on the incorporation of labelled methylcholantrene into mouse embryonic cells. | the incorporation of radioactive labelled methylcholanthrene into cba/t6t6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation counting techniques. during 24 hrs treatment time at the applied methylcholanthrene concentrations (0.01-2.5 mug/ml) the proportion of cells labelled with 3h-methylcholanthrene and the number of grains above the cells showed a relationship with the duration of treatment and also with the do ... | 1976 | 130740 |
| proteochondroitin sulfate a in the euglobulin fraction of human plasma. | euglobulin fraction of human plasma was extracted with 0.01 m phosphate buffer (ph 7.3) (pb) containing 1 m nacl. the substances in the extract were separated by deae-cellulose column chromatography into two uronic acid-containing fractions (0.5 fr and 0.75 fr). the major fraction (0.75 fr) was eluted at the void volume in gel filtration on sephadex g-200, yielding 0.75-g fr. 0.5 fr and 0.75 fr and their pronase digestion products (0.5-p fr and 0.75-p fr) together with 0.75-g fr were examined by ... | 1976 | 133103 |
| [study of the role or weaning and of androgens in the determinism of adrenal sexual dimorphism at the moment of puberty in the guinea pig]. | sexual dimorphism of the adrenal, which appears at puberty in guinea-pig, is not the fact of weaning. this dimorphism is suppressed by castration in male or injection of testosterone in female. testis androgens are the cause of the lower values of plasma and adrenal cortisol concentrations and of adrenal weight noticed in male compared with female between days 20 and 90 of postnatal life. | 1976 | 134790 |
| site of hydrolysis of collagen by hot trichloroacetic acid. | when calfskin collagen is treated with trichloroacetic acid at 90 degrees c, it is hydrolyzed to a mixture of peptides, some of which are quite small. cleavage of collagen by acid seems to occur at bonds between proline (or hydroxyproline) and other amino acids, with only a limited specificity for which amino acid donates its amino group to the susceptible peptide bond. | 1976 | 134865 |
| a stabilised tris(hydroxymethyl)aminomethane adduct in reduced collagen. | the reduction of collagen with sodium [3h] borohydride in the presence of tris buffer results in the stabilization of a schiff base adduct which is formed between allysine residues and tris(hydroxymethyl)aminomethane. the reduced, radioactive derivative of this adduct has been identified in hydrolyzates or reduced collagen. it elutes before hydroxylysine on an amino acid analyzer column close to the position of dihydroxylysinonorleucine. similar artifacts may occur when aldehydes present in or a ... | 1976 | 134871 |
| [bdellovibrio bacteriovorus as a factor in the self-purification of river water]. | | 1976 | 134929 |
| liver plasma membrane enzyme activities following glutaraldehyde fixation. | the wachstein-meisel atpase histochemical method has been previously used to demonstrate the ultrastructural localization of this enzyme in both whole liver and isolated plasma membranes following fixation in glutaraldehyde. in the present study biochemical assay, of liver plasma membrane enzymes following fixation in cold 2.5% glutaraldehyde showed that approximately 40% of mg2+-atpase, but only 4% of (na+-k+)-atpase activity remained in membranes from either control or anit-treated rats. in ad ... | 1976 | 135243 |
| suppressor mechanisms in neonatally acquired tolerance to a gross virus-induced lymphoma in rats. | tolerance to a highly immunogenic gross virus-induced tumour in wistar/furth rats (c58nt)d was produced by neonatal infection of the rats with the virus. these rats failed to reject the tumours when challenged 8 weeks after virus inoculation and to mount the appropriate cell-mediated immune response to the tumour. the mechanisms involved were studied in vivo by adoptive transfers into sub-lethally irradiated rats of tumour cells mixed with spleen cells and/or sera from normal, tolerant, or tumou ... | 1976 | 135385 |
| effects of bumetanide on sodium transport of the isolated frog skin and on renal na-k-atpase. | the effects of bumetanide, a new potent diuretic, on net sodium transport of the isolated frog skin and on rat renal na-k-atpase were studied. a dose-related decrease in short-circuit current and potential difference with increased electrical resistance was observed when bumetanide was added to the corial side of the skin. addition to the epithelial side resulted in enhanced net sodium transport with decreased electrical resistance. when applied to the corial side it abolished vasopressin- and a ... | 1976 | 138861 |
| inhibition of (na+ + k+)-stimulated atpase of heart by fatty acids. | | 1977 | 140941 |
| some observations on the diurnal variation of mitosis in the stratified squamous epithelium of wounded tympanic membrane. | a study of mitosis in the stratified squamous epithelium of the tympanic membrane of the guinea-pig was made after wounding this organ at 09.00 h in one series of animals and at 21.00 h in a second series. it was found that the diurnal variation of mitosis was abolished by the injury. this finding corresponds with a basic requirement of the chalone-adrenaline hypothesis which is considered to be a factor in the mitotic control of epidermal cells. it was also found that the maximum number of divi ... | 1977 | 143347 |
| a comparison of the biological and biochemical properties of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose. | 1-4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea (acnu) is a water-soluble nitrosourea that has produced delayed hematological toxicity in man during phase 1 clinical trials. acnu has in vitro alkylating activy 40% less than that of 2-[3-(2-chloroethyl)-3-nitrosoureido]-d-glucopyranose (chlorozotocin) but shares the property of negligible carbamoylating activity with the latter compounds. acnu is highly active against murine l1210 leukemia. however, the maximum therapeutic ... | 1978 | 145314 |
| some new perspectives on the biological effects of asbestos. | | 1977 | 145364 |
| e. coli phosphofructokinase synthesized in vitro from a cole1 hybrid plasmid. | a hybrid plasmid, plc 16-4, from the cole1-dna (e. coli) bank of clarke and carbon (1976) carrying pfka was used to program an in vitro protein synthesis system from e. coli. phosphofructokinase was the main product, as determined by enzyme assay, immunoprecipitation and gel electrophoresis. the enzyme was synthesized in vitro without added camp at a rate (enzyme/genome/h) ca. 30% the in vivo value, a higher efficiency than usually found in cell free systems. the plasmic molecular weight is ca. ... | 1977 | 145390 |
| [clinical and laboratory diagnosis of pseudotuberculosis]. | | 1977 | 146304 |
| [problems of the epidemiology of pseudotuberculosis in leningrad]. | | 1978 | 148740 |
| influence of fibrinogen degradation products (fdp) on the atpase activity in the rat heart. | influence of fibrinogen degradation products (fdp) on the atpase activity in the rat heart. acta physiol. pol., 1978, 29 (2): 185--187. the influence of dialysable fibrinogen degradation products (fdp) on the atpase activity was studied. it was found that fdp augment the mg(2+)-- dependent atpase and slightly decrease the (na+--k+) dependent atpase in the rat heart. it is concluded that biological activity of examined peptides depend on other mechanisms than the direct effect on atpase in the he ... | 1978 | 148831 |
| isolation of neurospora crassa-bovine l-glutamate dehydrogenase hybrids [proceedings]. | | 1978 | 154423 |
| isolation of neurospora crassa-bovine l-glutamate dehydrogenase hybrids [proceedings]. | | 1978 | 154423 |
| [1st cases of pseudotuberculosis in alma-ata]. | | 1979 | 154587 |
| [first cases of isolation of the agent of pseudotuberculosis from humans in alma-ata]. | | 1979 | 154814 |
| enhancement by caffeine of neocarzinostatin cytotoxicity in murine leukemia l1210 cells. | posttreatment incubation with nontoxic doses of caffeine resulted in enhancement of cell lethality and inhibition of cell growth in l1210 mouse leukemia cells which had been exposed to a protein antibiotic, neocarzinostatin. in addition, caffeine treatment appeared to inhibit the eventual maturation of newly synthesized dna in l1210 cells following exposure to this antibiotic. these results, indicating the existence of caffeine-sensitive repair in l1210 leukemia cells treated with neocarzinostat ... | 1979 | 154973 |
| collagen phagocytosis by stimulated mouse peritoneal macrophages in vitro. | | 1979 | 161578 |
| accelerated immune complex nephritis due to mesangial overloading in spontaneous hypertensive (shr) rats. | immune complex nephritis induced by bovine serum albumin (bsa) and horseradish peroxidase (hrp) was superimposed upon spontaneous hypertensive rats (shr rats) which were pretreated with polyvinyl alcohol (pva). pva accumulated predominantly in the mesangium, and the superimposed nephritis developed more accelerated glomerular damage with marked capillary deposition of immune complexes than control animals which were not pretreated with pva. | 1979 | 161594 |
| kinetics of glycerol uptake by the perfused rat liver. membrane transport, phosphorylation and effect on nad redox level. | the kinetics of glycerol uptake by the perfused rat liver were determined according to a model which includes membrane transport, intracellular phosphorylation and competitive inhibition of glycerol phosphorylation by l-glycerol 3-phosphate. the membrane transport obeys first-order kinetics at concentrations below 10 mm in the affluent medium. the k-m of the glycerol phosphorylation was 10 mum and the k-i of the l-glycerol 3-phosphate inhibition was 50 mum. the maximum activity (v) was 3.70 mum ... | 1975 | 164217 |
| cyclic adenosine 3',5'-monophosphate in guinea-pig cerebral cortical slices: studies on the role of adenosine. | | 1975 | 165264 |
| genetics of cell transformation by simian virus 40. | the results described in this paper indicate that the integration of the sv40 genome into human chromosome 7 results in the transformation of the human cells and in the expression of sv40-induced antigens. if integration of the sv40 genome in human chromosomes other than 7 ever occurs, it does not result in cell transformation and the expression of the virus-induced antigens. the expression of the sv40 t antigen in different monkey cells transformed by an adeno 7-sv40 hybrid is also related to a ... | 1975 | 169077 |
| discussion: nigrostriatal projections and the "dopamine report". | | 1975 | 173061 |
| [incorporation of low molecular sh-containing compounds in nitrosyl complexes of nonheme iron in cell-free and cell preparations]. | it has been shown that the endogenic low molecular sh-containing compounds in non-cellular liver and yeast preparates include in nitrosyl non-haem iron complexes at basic ph and in result of addition of iron salts into these preparates. the content of nitrosyl non-haem complexes with sh-containing low molecular compounds is not more than 0,5-1% of the quantity of identical non-haem iron complexes with rs-groups of proteins. the low content of these complexes appear to be due to as the low conten ... | 1975 | 173411 |
| cyclic amp in pancreatic acinar cells: effects of gastrointestinal hormones. | in the presence of 5 mm theophylline, secretin and vasoactive intestinal peptide (vip) each increased cyclic adenosine 3':5'-monophosphate (cyclic amp) in acinar cells isolated from guinea pig pancreas. without theophylline, neither peptide altered cellular cyclic amp. glucagon, which is similar to secretin and vip both in chemical structure and spectrum of biologic activities, neither stimulated cellular cyclic amp nor inhibited the stimulation produced by secretin or by vip. other agents which ... | 1976 | 173615 |
| effect of acute inhibition of adrenocorticotrophin secretion on plasma corticosteroids in the rhesus monkey (macaca mulatta). | the half-life of plasma cortisol in the rhesus monkey (m. mulatta), determined by two methods, was about 130 min and longer than that in man; it was unaffected by administration of dexamethasone. dexamethasone (5 mg, i.v.) immediately inhibited the secretion of acth from the monkey pituitary. the plasma half-life of nh2-terminal immunoreactive acth was found to be about 55 min which was much longer than the biological half-life. the adrenal synthesis of cortisol was inhibited by metyrapone which ... | 1975 | 173773 |
| tropical cirrhosis and hepatoma. | | 1976 | 173844 |
| effects of divalent cations and of catecholamines on the late response of the superior cervical ganglion. | the characteristics of the late response of the superior cervical ganglion of dogs were studied by close-arterial injection of catecholamines and divalent cations to the ganglion. 2. dopamine, noradrenaline and adrenaline inhibit the late response as well as ganglionic activity induced by other means. the effect of dopamine is brief but that of adrenaline is prolonged. 3. cd2+, co2+, ni2+, zn2+, hg2+ and fe2+ markedly potentiate the late response, whereas mn2+, ca2+ and mg2+ inhibit it. 4. may p ... | 1975 | 175148 |
| specificity of the stimulation of in vitro ribonucleic acid synthesis by guanosine 5'-diphosphate 3'-diphosphate. | the in vitro synthesis of ribonucleic acid (rna) by s-30 extracts of escherichia coli k-12 is stimulated from two-to fourfold by 0.16 mm to 0.32 mm guanosine 5'-diphosphate 3'-diphosphate (ppgpp) when either gammaci857st68h80 deoxyribonucleic acid (gammah80 dna), gammah80dilv dna or gammah80dlac dna are employed as templates. hybridization analysis of the 3h-rna product transcribed from gammah80dilv dna in the presence of ppgpp indicates that both bacteriophage- and bacterial-specific transcript ... | 1975 | 175258 |
| proceedings: species variation in motor transmission to the retractor penis muscle. | | 1976 | 177140 |
| "refractory-like" state of heavy-meromyosin induced by the reaction of acto-heavy-meromyosin with inosine triphosphate. | | 1975 | 178637 |
| disseminated herpesvirus infection. association with primary genital herpes in pregnancy. | a patient with primary herpes simplex virus (hsv) type 2 genital infection had dissemination in the 37th week of her first pregnancy. this was manifested by severe hepatitis, pancreatitis, and genital lesions. temporary improvement followed the delivery of a healthy infant by cesarean section. encephalitis became evident on the third postpartum day, and recovery was complicated by profound bradycardia, possibly due to viral myocarditis. vidarabine was administered for seven days, and the patient ... | 1976 | 178938 |
| effect of isoproterernol and aminiphylline on cyclic amp levels of guinea pig macrophages. | | 1976 | 186194 |
| properties of a baboon lymphotropic herpesvirus related to epstein-barr virus. | three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (papio hamadryas) by co-cultivation of the lymphocytes with x-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. a herpesvirus, associated with each cell line, was identified by immunofluorescence, molecular hybridization and electron microscopy. antigenic comparison with epstein-barr virus (ebv) showed that the ba ... | 1976 | 186420 |
| interrelationships between the central nervous system and patterns of adrenocorticotropic secretion following acute exposure to severe environmental conditions. | | 1976 | 187557 |
| experimental evaluation of paracetamol antidotes. | | 1976 | 193746 |