| in vitro studies of the replication of moloney murine leukemia virus. | | 1979 | 90575 |
| biological role of gramicidin s in spore functions. studies on gramicidin-s-negative mutants of bacillus brevis atcc9999. | gramicidin-s-negative mutants of bacillus brevis atcc9999 have been isolated with a remarkly higher yield after ethidium bromide or acridine orange treatment, than after n-methyl-n'-nitro-n-nitrosoguanidine treatment. four (miv, smr170, r5 and eb 16) of 38 isolated mutants were characterized with respect to the lesion in gramicidin-s-synthesizing activity. the mutants sporulate to the same extent as the parental strain except mutant smr 170 which sporulates less. however, mutant spores were more ... | 1979 | 90616 |
| cell differentiation in human gastric gland as revealed by nuclear binding of tritiated actinomycin. | the nuclear binding of h3 actinomycin, which is closely linked to the differentiation phenomenon, was studied in human normal gastric mucosa. actinomycin binding decreases in cells which differentiate and becomes very low in fully differentiated cells. in the gastric pits, there is a decreasing gradient of labelling from the deeper stem cells to the well-differentiated superficial cells. this indicates that migration and renewal of the surface epithelium occurs following a 'pipe-line' system. al ... | 1979 | 90638 |
| relative affinity of antisera for myelin basic protein (mbp) and degree of affinity heterogeneity. | | 1979 | 90641 |
| characterization of the antigenic determinants of cholera toxin subunits. | the antigenic specificity of purified preparations of a subunit, b subunit, alpha chain, and gamma chain of cholera toxin was studied by double immunodiffusion and radioimmunoassay with antisera produced in rabbits and mice. rabbits immunized with a subunit produced serum antibodies which were capable of binding radiolabeled a subunit, alpha chain, and b subunit. rabbits immunized with alpha chain produced serum antibodies that would bind radiolabeled alpha chain and a subunit. rabbits immunized ... | 1979 | 90654 |
| lymphocyte viability and function following ex-vivo splenic perfusions in dogs. | | 1979 | 90722 |
| rat alpha-macrofetoprotein (acute-phase alpha 2-macroglobulin) during hepatocarcinogenesis. | rat alpha-macrofetoprotein (amf) and alpha-fetoprotein (afp) are secreted by the fetal liver and become elevated in serum during hepatocarcinogenesis and in animals bearing hepatocellular carcinomas. it has been suggested that these fetal plasma proteins may be influenced by related control mechanisms. the experiments presented herein examined the early responses of these plasma proteins during hepatocarcinogenesis using the hepatocarcinogens acetylaminofluorene and diethylnitrosamine. under the ... | 1979 | 89903 |
| pattern of condensation of mouse and chinese hamster chromosomes in g2 and mitosis of 33258-hoechst-treated cells. | | 1979 | 89960 |
| enzymatic tracers in the study of vascular permeability. | elucidation of the ultrastructural basis of vascular permeability was aided by the development of cytochemical techniques for visualizing the distribution, within the vessel wall, of intravenously injected peroxidatic enzymes of varying molecular size. tracer enzymes available range from 10 a (hemeoctapeptide) to 52 a (catalase) effective molecular radius. the use of enzymatic probe molecules assumes a thorough characterization of: (a) the molecular charge (isoelectric point of the native enzyme ... | 1979 | 90073 |
| modulation of the host response in human schistosomiasis. i. adherent suppressor cells that inhibit lymphocyte proliferative responses to parasite antigens. | | 1979 | 90093 |
| m467: a murine iga myeloma protein that binds a bacterial protein. i. recognition of common antigenic determinants on salmonella flagellins. | we have studied the binding of m467, an iga murine myeloma protein, to flagellin from seven species of salmonella. it was found that m467 was reacting with antigenic determinants that were common to all the flagellins studied. these determinants were not related to serotypic antigens. electronmicrographs of unreduced m467 showed a variety of polymeric species bound to flagella in a manner that could produce immobilization as well as agglutination and precipitation through cross-linking of antige ... | 1979 | 90100 |
| preparative isolation of the cell receptor for immunoglobulin e. | | 1979 | 89114 |
| characterization of in vitro proliferative responses of human lymphocytes to leishmanial antigens. | leishmaniasis is an intracellular protozoal infection for which host defense is believed to depend on cellular immune mechanisms. the in vitro proliferative responses of lymphocytes from patients with leishmaniasis and from control subjects to leishmanial antigens were examined. only lymphocytes from patients responded to 1 microgram of leishmanial antigen/ml, whereas both patient and control lymphocytes responded to 10 micrograms/ml. the nonspecific responses were most likely not due to a mitog ... | 1979 | 90105 |
| differential growth inhibition in two human carcinoma cell lines by cyclic adenosine 5'-monophosphate analogs. | the inhibition of cell replication in two human carcinoma cell lines by various cyclic amp analogs was explored. in all instances, the addition of the cyclic nucleotide phosphodiesterase inhibitor 1-methyl-3-isoburylxanthine resulted in synergistic growth inhibition by the analogs. a correlation was found between an analog's ability to inhibit growth and its ability to activate protein kinase. a differential effect of the breakdown product 8-bromo-amp (8-bramp) on cell replication in the two cel ... | 1979 | 90151 |
| biosynthesis of an unglycosylated envelope glycoprotein of rous sarcoma virus in the presence of tunicamycin. | cells stably infected with rous sarcoma virus were treated with tunicamycin to prevent the glycosylation of the precursor (pr92gp) to the two viral envelope glycoproteins gp85 and gp35. pretreatment of the cells for 4 h with the antibiotic resulted in a 90% reduction in [3h]mannose incorporation into total cellular glycoproteins, intracellular viral glycoproteins, and released virus particles. protein synthesis and virus particle formation were not significantly affected by the treatment. a new ... | 1979 | 90167 |
| [pharmacological properties and antitumor activity of a preparation diiodo-benzo-tepa in experiments]. | experimental data on the pharmacokinetics, toxicity, antitumor activity of the antitumor drug diiodo-benzo-tepa are reported. | 1979 | 90429 |
| cells of origin of the spinocerebellar tract in the rat, studied with the method of retrograde transport of horseradish peroxidase. | following injections of horseradish peroxidase into the cerebellum, the distribution of labeled neurons was studied in the whole length of the spinal cord of the rat. to find the ascending side of the axons, injections were made following hemisections at c1 or between c1 and c2. labeled spinocerebellar tract neurons were classified into two groups according to the axonal course in the spinal cord; one is composed of neurons with uncrossed ascending axons and the other, neurons with crossed ascen ... | 1979 | 90539 |
| symposium on uropathology. | | 1979 | 93566 |
| genetic variation in the m antigen of group a streptococci: reassortment of type-specific markers and possible antigenic drift. | the phylogenetic relationships of 73 strains of group a streptococcus isolated over a six-year period from a population with a high prevalence of streptococcal infections were analyzed with use of four serotype-specific markers: the serum opacity factor (of), the t antigen, the determinant of the m antigen that precipitates with antibody, and the m antiphagocytic determinant. of inhibition tests divided the strains into five subtypes: a, b, c, d, and e. strains within subtypes a, b, and c shared ... | 1979 | 93611 |
| location of bladder preganglionic neurons within the sacral parasympathetic nucleus of the cat. | sacral parasympathetic preganglionic neurons innervating the urinary bladder were labelled by applying horseradish peroxidase (hrp) to branches of the pelvic nerve at the neck of the bladder. bladder preganglionic cells were located primarily in the intermediolateral grey matter of sacral cord segments 1, 2 and 3 and extended from the ventral end of the central canal to the inferior margin of the dorsal horn. dendrites extended into the dorsolateral funiculus, toward the lateral edge of the dors ... | 1979 | 93725 |
| increased urine histamine after challenge of contact sensitivity in the mouse. | the urinary excretion of histamine was observed daily during the development of contact sensitivity to picryl chloride in the mouse. after challenge, effected by painting the ears, urine histamine increased about four fold, while the histamine content in the ears did not change significantly. it is suggested that during challenge there is a general release of histamine, which may be the result either of an immediate hypersensitivity reaction or an effect of anaphylatoxin formation after compleme ... | 1979 | 92143 |
| the antagonistic effect of dexamethasone and insulin on alpha-fetoprotein secretion by cultured h4-ii-e-c3 cells derived from the reuber h-35 hepatoma. | | 1979 | 92316 |
| guinea-pig alpha 1 microglobulin. isolation and properties in comparison with human alpha 1 microglobulin. | | 1979 | 92407 |
| estrogen and progestin regulation of the progesterone receptor concentration in human endometrium. | the concentration of the progesterone receptor (pr), both cytosol and nuclear, has been measured in the endometrium of 31 normal menstruating women during the 2 phases of their menstrual cycle and compared with the plasma 17 beta-estradiol and progesterone concentrations. there was no relationship between pr concentrations and the plasma steroid levels when the 2 phases of the cycle were considered; however, a statistically significant correlation (r = 0.70; p less than 0.005) was observed betw ... | 1979 | 92478 |
| nonspecific light loss and intrinsic dna variation problems associated with feulgen dna cytophotometry. | nonspecific light loss by the cell-wall-plus-cytoplasm (cwc) can cause a 50% increase in feulgen absorption units in peanut root-tip nuclei as determined by scanning at 450 nm, whereas this phenomenon is not evident with chicken erythrocytes. a two wavelength scanning method of subtracting nonspecific 450 nm absorption from 550 nm feulgen absorption values eliminated the nonspecific light loss in cwc, however, the two wavelength scanning method is time consuming and somewhat impractical with a r ... | 1979 | 92496 |
| selective aromatic-hydrophobic binding and fractionation of immunoglobulin by means of phenyl-(ch2)n-nh-substituted agaroses. | | 1979 | 92988 |
| dipyridamole affects myocardial adenosine kinase activity. | adenosine kinase (en 2.7.1.20) from rat and dog heart was purified until it was devoid of adenosine deaminase activity. a stimulation of adenosine kinase activity by dipyridamole was observed when the enzyme was assayed under optimal conditions. at low substrate concentrations adenosine kinase was inhibited by the drug. it increased the km for adenosine sevenfold. the effects of dipyridamole were mg2+-dependent. the adenosine-sparing action of dipyridamole at low substrate concentrations is in k ... | 1979 | 93442 |
| new surgical management in the cleft palate repair and its histological aspects. | | 1979 | 94731 |
| effect of lysolecithin on pig platelet collagen : glucosyltransferase [proceedings]. | | 1979 | 94798 |
| 1-isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic amp in brain slices. | | 1979 | 93674 |
| antigenic changes associated with liver carcinogenesis. | carcinogen-induced experimental hepatomas are often characterized by new individually distinct antigens capable of inducing tumor immunity in syngeneic hosts. these antigens arise as a consequence of cell-carcinogen interaction and may result from modification or replacement of normal cell-surface components. their role in immunosurveillance is not established, but they offer a target for tumor immunotherapy. reexpressed fetal antigens have also been detected, either as secretory products (alpha ... | 1979 | 89200 |
| [enzyme therapy in pathogenic treatment of extrapulmonary tuberculosis (experimental study)]. | | 1979 | 93744 |
| the weight of the dorsal, lateral and medial prostatic lobes in man. | the weight of the prostatic lobes in man was determined in an atuopsy series comprising 158 cases. in children the medial pair of lobes formed half of the prostate gland. the "normal" mean weights in adult men of the dorsal, lateral and medial pair of lobes were 3.6, 3.4 and 4.3 g, respectively. in adult men there was no change in lobe weight with increasing age. in subjects who died after protracted disease all of the prostatic lobes had decreased in weight. in subjects with periurethral adenom ... | 1979 | 93779 |
| myelin basic protein treatment of experimental allergic encephalomyelitis in monkeys. | treatment of experimental allergic encephalomyelitis (eae) in two strains of monkeys with large amounts of myelin basic basic protein (bp) fails unless an adjunct is also used. in both strains the adjunct by itself is more effective than bp by itself, but in the one strain which could be investigated sufficiently, the combination can be made almost totally effective in reversing eae. the adjunct varies with the strain of monkey, an antibiotic in macaca mulatta and a steroid in macaca fasciculari ... | 1979 | 93874 |
| sk&f 75073, new parenteral broad-spectrum cephalosporin with high and prolonged serum levels. | sk&f 75073, a new parenteral cephalosporin, was found to have broad in vitro and in vivo antibacterial activity including isolates usually resistant to cephalothin and cefazolin. this activity included indole-positive proteus and enterobacter species and some serratia isolates. proteus mirabilis strains were particularly susceptible, as were haemophilus influenzae and neisseria species. the activity of sk&f 75073 against gram-positive bacteria was poorer than that of the control cephalosporins. ... | 1978 | 96734 |
| effects of painful footshock on self-stimulation behaviour of rats and influence of naloxone on this behaviour [proceedings]. | | 1979 | 92231 |
| [comparison between serum lh and fsh levels in male and female rats during the perinatal period]. | in the newborn female rat, no transient lh and fsh serum surges were observed between 0 and 2 hrs., as compared with the newborn male. in the newborn female, a progressive increase in serum gonadotropins was observed between 2 and 6 hrs. these results indicate that, at birth, the pituitary-gonadal axis reacts in a different way in male and female rats. | 1978 | 96975 |
| effects of progesterone on the oestrogen-stimulated uterus: a comparative study of the mouse, guinea pig, rabbit and sheep. | to examine more closely the anti-oestrogenic action of progesterone (p), its effect on various parameters in the 17 beta-oestradiol (e2)-primed uterus of the mouse, guinea pig, rabbit and ewe was studied. changes in uterine wet weight, rate of in vitro protein synthesis, protein : dna and rna : dna ratios, peroxidase activity and the level of cytosol receptors for e2 and p were measured. considerable between-species differences in the effect of p on these parameters were observed. the anti-utero ... | 1979 | 95094 |
| thirst and renal excretion of water and electrolytes during pyrogen fever in dogs. | body temperature, water intake, urine output, sodium and potassium excretion, osmolal and free water clearance, plasma osmolality, sodium and potassium concentrations and osmotic thirst were examined in conscious dogs during pyrogen fever and compared to those found under control conditions. arterial blood pressure and central venous pressure were also measured in some experiments. administration of pyrogen produced transient but significant decreases in urine output and striking increases in th ... | 1979 | 93885 |
| experimental infection of chimpanzees with the norwalk agent of epidemic viral gastroenteritis. | a fecal filtrate of human origin containing the norwalk agent of epidemic viral gastroenteritis was administered by stomach tube to chimpanzees in an attempt to induce diarrheal disease. significant postchallenge serum antibody rises against norwalk viral antigens were demonstrated in all animals using the techniques of immune electron microscopy and radioimmunoassay. in addition, viral antigens were detected in feces from five of nine animals using radioimmunoassay. clinical illness characteriz ... | 1978 | 97364 |
| semicarbazide-sensitive amine oxidase in rat aorta: a plasma-membrane enzyme [proceedings]. | | 1979 | 93954 |
| the structure and evolution of the hla--bw4 and bw6 antigens. | the hla--bw4 and bw6 antigenic determinants have been shown to co-migrate with hla--b determinants on gel-filtration, sucrose density gradient centrifugation and affinity chromatography, using lens culinaris lectin and antibody against human beta 2 microbulin. these and other published data imply that the hla--bw4 and bw6 determinants reside on the same polypeptide chain as other hla--b locus determinants. the implications of this in terms of the evolution of cross reacting groups of antigens at ... | 1979 | 91209 |
| [histochemical studies on the structure and the age changes of descemet's membrane in cattle (author's transl)]. | descemet's membrane of 15 cattle-corneas, aged 6 month to 13 years was studied by various histochemical and morphometric methods. 3 zones could be differentiated. zone 1 is relatively small and does not show significant changes with age; zone 2 comprises the main part of descemet's membrane, its diameter increased with age. zone 2 is rich in sulfated glycosaminoglycans. zone 3, below the endothelial lining, does not develop before the 3rd and 5th year of life and stains different from zone 2. | 1979 | 94246 |
| the identification of human h-y antigen and testicular transformation induced by its interaction with the receptor site of bovine fetal ovarian cells. | beta 2m(-), hla (-) daudi human male burkitt lymphoma cells excreted a group of protein subunits that shared three distinctive characteristics; their conspicuously longer half-lives compared to more hydrophilic daudi excreted proteins, their tendency to form progressively larger polymers by means of interchain disulfide bridges, and the extreme hydrophobicity of these polymers. the plasma membrane of extragonadal somatic cells absorbed 1.2 to 2.8% of these hydrophobic proteins. the unoccupied h- ... | 1979 | 94287 |
| a model study for determining the mechanism of exposure of leukemia-specific antigen on dinitrophenylated leukocytes. | | 1979 | 94299 |
| priming increases the amount of interferon mrna in poly(ri).poly(rc)-treated l cells. | priming by mouse interferon pre-treatment resulted in an accumulation of interferon mrna in poly(ri).poly(rc)-treated l cells, starting early in the period of interferon synthesis. on electrophoresis, the priming activity of an interferon preparation co-migrated with the antiviral activity, which suggests identity of the functional principle(s) for these activities. | 1979 | 94345 |
| comparison of the antibodies elicited by the individual structural polypeptides of foot-and mouth disease and polio viruses. | antibody produced against preparations of vp1, one of the four structural polypeptides of foot-and-mouth disease virus, neutralized the virus and reacted with both full and empty particles in radioimmunoassays (ria). antiserum against vp2 reacted with artificial empty particles of the virus but not with full particles. in contrast, none of the individual polypeptides of poliovirus produced antisera which neutralized the virus nor reacted with it in ria. however, antisera produced with vp1 and vp ... | 1979 | 94352 |
| [some aspects relating to the aflatoxin generation during the self-heating of cereals]. | in a stored batch of grain which was already affected by mould-formation tests were carried out with the known aflatoxin producer aspergillus flavus. a significantly lower aflatoxin production ensued if the mould growth was not connected with self-heating of the stored product. however, in conformity with increasing mould formation the germinating power was adversely affected and the significant signs (fatty acid number, reductive and none-reductive sugars) were influenced in the grain, irreleve ... | 1978 | 98933 |
| thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium. | the effects of alterations in thyroid state on cardiac alpha-adrenergic receptors were investigated by the binding of [3h]dihydroergocryptine (dhe), a potent alpha-adrenergic antagonist. in seven experiments, cardiac membranes from euthyroid rats bound 47 +/- 9 fmoles dhe/mg protein (mean +/- se) at saturation and demonstrated a dissociation constant (kd) of 2.5 +/- 0.4 nm. hyperthyroidism, produced by parenteral injection of triiodothyronine, significantly reduced the binding of dhe at all conc ... | 1979 | 94388 |
| pattern of the ventilatory response to transient hypoxia in man: differences from transient hypercapnic test. | the pattern of change in ventilatory variables after inhalation of pure n2 for two breaths was studied in normal children and adults. in six subjects the trends of change were compared to the ventilatory response to transient hypercapnia. we observed differences in the patterns of increasing ventilation with an initial abrupt increase of tidal volume for transient hypoxia and a progressive change for hypercapnia. in both cases respiratory frequency was progressively but unsystematically enhanced ... | 1979 | 92921 |
| natural distribution of squirrel monkey retrovirus proviral sequences in primate dnas. | 3h-labelled 70s rna of squirrel monkey retrovirus (smrv) hybridized to a high degree (greater than 52%) to the dna of various tissues of two squirrel monkeys. hybridization of the same probe to dnas of other primates including new world monkeys (woolly monkey, capuchin, owl monkey), old world monkeys (rhesus, african green), apes (gibbon, chimpanzee), and human (a204 cells infected with mpmv) revealed no significant hybridization. analysis of the kinetics of hybridization indicated that smrv pro ... | 1978 | 99487 |
| organization of the unique and repetitive sequences in feather keratin messenger ribonucleic acid. | | 1979 | 92997 |
| [synthesis of virus-specific products following introduction of tobacco mosaic virus rna pereparations and the native virus into acetabularia]. | the possibility to synthesize the viral-specific products after microinjection of tobacco mosaic virus (tmv) preparations and the tmv rna into the single-celled seaweed acetabularia was studied. the accumulation of the newly synthesized protein and double-stranded rna 24 hours after injection of tmv rna and native virus preparations was demonstrated by immunological and immunofluorescent methods. the virus titer sharply dropped 3--4 hours after introduction into acetabularia and in 48 hours it r ... | 1978 | 96330 |
| compensatory and conditioned feeding responses to scheduled glucose infusions in the rat. | | 1978 | 96348 |
| effects of tamoxifen on the binding and metabolism of testosterone by human prostatic tissue and plasma in vitro. | the in-vitro metabolism of testosterone in benign and malignant prostatic tissue was examined and distinct quantitative differences between the two types of specimens were observed. the major metabolite of testosterone in the hyperplastic prostate was 5 alpha-dihydrotestosterone and a high 3 alpha(beta)-hydroxysteroid dehydrogenase activity was also detected. in the malignant tissue, 5 alpha-reductase activity was considerably reduced and there was little or no androstanediol formed; the 17 beta ... | 1979 | 94084 |
| prostaglandin synthesis inhibition and monoamine metabolites in the rat brain. | the effect of indomethacin 3 mg/kg on levels of homovanillic acid (hva), 4-hydroxy-3-methoxy phenyl ethylene glycol (hmpg) and 5-hydroxy indol acetic acid (5hiaa) was studied in rat striatum and olfactory tubercle with and without pretreatment with morphine 10 mg/kg. indomethacin caused a small decrease in resting levels of hva in striatum but not in olfactory tubercle. no effects were seen on resting or morphine induced changes in the levels of these monoamine metabolites. likewise indomethacin ... | 1979 | 94946 |
| [the behaviour of some histochemical reactions in testicle tissue of a white rat as a result of kaptan action (author's transl)]. | | 1978 | 94984 |
| activity of azlocillin and mezlocillin against gram-negative organisms: comparison with other penicillins. | the activities of azlocillin and mezlocillin were compared with those of carbenicillin, ticarcillin, and pirbenicillin against a wide range of gram-negative organisms. the two new drugs were considerably more active than carbenicillin against klebsiella species and escherichia coli. carbenicillin was twice as active against proteus mirabilis as mezlocillin and four times as active as azlocillin. against pseudomonas aeruginosa, azlocillin was eight times as active as carbenicillin. azlocillin and ... | 1978 | 96726 |
| inflammatory, tumor initiating and promoting activities of polycyclic aromatic hydrocarbons and diterpene esters in mouse skin as compared with their prostaglandin releasing potency in vitro. | release of prostaglandin e2 (pge2) in cultured peritoneal macrophages of nmri mice by skin irritant tumor initiators and promoters was investigated. initiators of the polycyclic aromatic hydrocarbon type, e.g., dmba, caused slight irritation on the mouse ear but even relatively high doses did not stimulate pge2-release to any measurable extent within 4 h after administration in vitro. apparently there is no correlation between irritation and initiating activity in mouse skin and pge2-release in ... | 1978 | 96935 |
| [intracellular distribution of two lysosomal enzymes in newborn rat liver]. | the distribution of two lysosomal markers (beta-acetylglucosaminidase and acid phosphatase) between liver fractions was studied in the newborn rat. the results indicate that after birth the hydrolase-bearing particles increased in size and had a lower density than the primary lysosomes. these modifications may be related to the autophagic-vacuole formation known to occur during this period. | 1978 | 96999 |
| insulin secretion in growth hormone-deficient children and the effect of the sulfonylurea drug glibenclamide on linear growth. | the effect of glucose on insulin release and the influence of glibenclamide on linear growth were determined in five growth hormone (sth) deficient children who were treated with human growth hormone. it was found that the administration of 5 i.u. of human growth hormone twice a week improved the defective insulin secretion while prolongation of the week improved the defective insulin secretion while prolongation of the interval between growth hormone injections to 7 days had no effect on beta-c ... | 1978 | 97083 |
| increased vasodepressor effect of prostaglandins a1 and e1 in renal hypertensive rabbits. | | 1978 | 97482 |
| demonstration of a murine cell surface component with affinity for exogenous beta 2-microglobulin. | murine and human beta 2-microglobulin (beta 2m) bind to various types of mouse cells. the binding is saturable and displays a single association constant of about 1 x 10(9) liter/mol. the binding of beta 2m to splenocytes was not affected by a variety of metabolic inhibitors but was temperature-dependent. it is suggested that the beta 2m "receptor" exhibits a temperature-dependent conformational change since the "receptor", whether integrated into the membrane or solubilized by the detergent tri ... | 1979 | 95108 |
| histamine-releasing effect of a corticotrophin derivative. ii. mechanism of action of histamine release by c 44 680-ba, compared with that of cpd. 48/80, dextran and triton. | the mechanism of the histamine-liberating action of the synthetic polypeptide c 44 680-ba, an alkyl-prolyl derivative of beta 1-19 corticotrophin, was investigated and compared with those of compound 48/80, dextran, melittin and triton x-100. it was found that the release of histamine from rat peritoneal cells induced by the polypeptide is dependent on temperature, ph, calcium ions and energy-providing processes. in regard to these criteria, the mode of action of this histamine liberator resembl ... | 1979 | 89804 |
| photolysis of mast cells in presence of protoporphyrin. | the effects of ultraviolet and visible irradiation in presence of protoporhyrin upon mast cells were investigated. rat peritoneal mast cells were suspended in a medium containing varying concentrations of protoporphyrin and were irradiated using a mercury vapor lamp. the release of histamine is related to both the concentrations of protoporphyrin and the period of irradiation. comparatively negligible amounts of histamine were released when the cells were irradiated in absence of protophyrin or ... | 1979 | 94207 |
| [method of indicating staphylococci in the bile]. | | 1979 | 91710 |
| genetics of the idiotype of strain akr antibodies to group a streptococcal carbohydrate; further evidence for a low degree of homology in the vh chromosomal region. | a new vh gene is described which governs the expression of idiotypes associated with the antibody response of strain akr mice to group a streptococcal carbohydrate (a-cho). this vh gene, termed achd, is identified using guinea pig antisera to a pool of strain akr antibodies to a-cho. the genetic polymorphism is revealed by quantitative differences in idiotype expression between different inbred strains. in recombinant inbred strains linkage to the ig-1d allotype allele of strain akr is demonstr ... | 1978 | 97871 |
| [prospects for the use of blood substitutes made in the ussr with the expired date of validity]. | as revealed, blood substitutes--aminopeptide, caseine hydrolysate, and hydrolysine with the expired date of validity could be used as the basis of nutrient media for the cultivation of bacteria. bacterial growth proved to be the optimum in addition to the blood substitutes of a 0.25--0.5% of yeast extract. | 1978 | 97885 |
| formylation of initiator trna methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression. | eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator trna which is found to be modified (formylated) in procaryotes and not in eucaryotes. in the present study, we show that formylation is required in vivo for the coordinate expression of the escherichia coli lactose operon. our experiments are co ... | 1978 | 98518 |
| effect of dopamine on renal blood flow of baboon in endotoxin shock. | renal vasodilation observed in canine endotoxemia did not occur during endotoxin shock in the baboon: in fact, renal artery blood flow was markedly reduced. infusion of dopamine in the baboon restored the renal artery blood flow. | 1978 | 98752 |
| methodological problems in the measurement of drug-induced rotational behaviour: continuous recording reveals time-course differences undetected by previous techniques. | rats were lesioned unilaterally in the medial forebrain bundle with either the catecholamine neurotoxin 6-hydroxydopamine or the indoleamine neurotoxin 5,6-dihydroxytryptamine. their rotational responses in automated rotameters to a challenge with the dopamine-receptor agonist apomorphine were compared using four different techniques in current use, and by assessment of complete rotation curves using both conventional statistical procedures and elementary computer-derived elements of curvature. ... | 1978 | 98782 |
| an ontogenic study of the acute inflammatory response in the fetal rhesus monkey. ii. the mediation of increased vascular permeability by histamine, compound 48/80 and bradykinin. | vascular permeability as a function of age was evaluated quantitatively and morphologically in skin of fetal rhesus monkeys given vasoactive mediators. the response was examined at 90, 120 or 150 days of gestation or at birth and compared to the response of yearling rhesus monkeys. skin sites were challenged with histamine, compound 48/80 or bradykinin. evans' blue and horseradish peroxidase were used as markers of vascular integrity. evans' blue was quantitated spectrophotometrically. vascular ... | 1978 | 98895 |
| jaundice and breast-feeding among alaskan eskimo newborns. | the course, incidence, and severity of neonatal jaundice was studied in 95 alaskan eskimo infants. breast-fed infants had higher bilirubin concentrations than bottle-fed babies. both groups experienced high bilirubin levels, similar to those previously reported in navajo and oriental infants but greater than those observed in whites and blacks. a marked capacity to inhibit hepatic glucuronyl transferase was observed in breast-milk specimens but only partly accounted for the bilirubin differences ... | 1978 | 99026 |
| spontaneous termination of reentry ventricular tachycardia in the late myocardial infarction period: an experimental study in the dog. | forty episodes of induced ventricular tachycardia in the late myocardial infarction period (4-6 days old) were analyzed in 12 dogs in an attempt to identify the possible mechanisms for the termination of reentry tachycardia. multiple epicardial and endocardial composite electrograms were recorded in and around the central ischemic zone of the infarction. during tachycardia, the earliest site of activation was identified in the epicardial surface of the border or normal zone immediately adjacent ... | 1979 | 95291 |
| isoprinosine as an immunopotentiator. | isoprinosine is a compound developed for antiviral use. the effects of isoprinosine on mouse responses to sheep red blood cells were studied over a wide range of doses, from 0.5 microgram/kg to 5 g/kg, i.p. administered at the time of i.v. immunization or as pretreatment for 7 days before antigenic stimulus. low doses, 50 microgram/kg to 50 mg/kg, significantly increased the numbers of igm- or igg-spleen antibody-forming cells. large doses, such as the ld50 (5 g/kg) or pretreatments where unable ... | 1979 | 95412 |
| fibrinogen turnover in pregnant rabbits during the first and last thirds of gestation. | although thrombin-mediated fibrinogen derivatives have been observed in normal pregnancy, an increased turnover of fibrinogen has been suspected but has not yet been demonstrated. fibrinogen turnover was studied in 14 pregnant and 10 nonpregnant female rabbits by use of purified rabbit 125i-labeled fibrinogen. in the last third of gestation the half life of fibrinogen was shortened by 45% and the fractional catabolic rate increased by 44% in comparison to the values for the first third of gestat ... | 1978 | 99036 |
| liver microsomal cytochromes p-450 and azoreductase activity. | hepatic microsomal azoreductase activity with amaranth (3-hydroxy-4[(4-sulfo-1-naphthalenyl)azo]-2,7-naphthalenedisulfonic acid trisodium salt) as a substrate is proportional to the levels of microsomal cytochrome p-450 from control or phenobarbital-pretreated rats and mice or cytochrome p-448 from 3-methylchol-anthrene-pretreated animals. in the "inducible" c57b/6j strain of mice, 3-methylcholanthrene and phenobarbital pretreatment cause an increase in cytochrome p-448 and p-450 levels, respect ... | 1978 | 96118 |
| lower levels of thyrotropin-releasing hormone-degrading activity in human cord and in maternal sera than in the serum of euthyroid, nonpregnant adults. | thyrotropin-releasing hormone (trh)-degrading activity was investigated in human cord, maternal, and euthyroid adult sera by measuring (a) the rate of disappearance of trh and (b) the rate of formation of degradation products. the rate of trh degradation in cord and maternal sera was 25-33% of that in euthyroid adult serum. concomitantly, in cord and maternal sera, the rate of formation of proline, a major trh degradation product in serum, was one-quarter to one-third that in euthyroid adult ser ... | 1978 | 96140 |
| aperistaltic ureter in upper urinary tract infection--cause or effect? | | 1978 | 99855 |
| [primate center program and virus research (author's transl)]. | | 1977 | 96588 |
| rifampicin plus nalidixic acid: a rational combination for the treatment of urinary infection. | | 1978 | 101503 |
| chromosome-membrane association in bacillus subtilis. iv. further purification of dna-membrane complex by using a combination of centrifugation and electrophoresis. | we have developed a simple procedure to purify a dna-membrane complex from bacillus subtilis by using a combination of centrifugation and electrophoresis. several unique proteins were detected in the purified complex. | 1978 | 101532 |
| the determination of antibody to streptococcus mutans serotypes in saliva for children ages 3 to 7 years. | the saliva of 29 children ages 3 to 7 years was followed by indirect immunoflourescence to determine the antibody reacting with the 5 different serotypes of s mutans. fluorescent antisera specific for alpha chain and gamma chain were used. statistical analysis of the data demonstrated a significant negative correlation between antibody of immunoglobin class (iga) to s mutans type b and the decayed, extracted and filled surfaces of deciduous teeth. | 1978 | 101566 |
| [studies on moraxella. ii. studies on the identification of moraxella by biochemical character (author's transl)]. | | 1977 | 101604 |
| [clinical studies of childhood empyema experienced for the past 12 years (author's transl)]. | | 1978 | 101626 |
| primum non nocere and the sydney funnel-web spider (continued). | | 1978 | 101753 |
| the organization, composition and matrix of hepatocyte nuclei exposed to alpha-amanitin. | alterations in the structure and molecular composition of avian hepatocyte nuclei were compared following administration in vivo of lethal and sub-lethal doses of alpha-amanitin. this toxin interferes with extranucleolar transcription by direct inhibition of rna polymerase ii activity. the resultant effects include: extensive condensation of chromatin, displacement of nucleoplasmic contents and fragmentation of nucleoli. changes in nuclear morphology were quantitated by stereometry and related t ... | 1978 | 96580 |
| clinical relevance of the liver-specific lipoprotein (lsp). | | 1978 | 96648 |
| autoradiographic localization of the uptake of 3h-beta-alanine in rat nervous tissue cultures. | autoradiographic studies on the uptake of 3h-beta-alanine have shown that, in spinal cord and brain stem cultures, both neurones and glial cells have accumulated the amino acid. in contrast, in cultures of cerebellum and dorsal root ganglia, 3h-beta-alanine was only t aken up by glial elements. | 1978 | 102522 |
| refractory sprue: recovery after removal of nongluten dietary proteins. | a 44-year-old woman with diarrhea, weight loss, and a small-bowel biopsy consistent with adult celiac disease failed to improve on a gluten-free diet. despite in-hospital supervision at two university medical centers and addition of corticosteroid therapy, diarrhea and wegith loss continued, resulting in life-threatening nutritional depletion. she was transferred to the university of chicago and made full nutritional recovery with total parenteral nutrition. exploratory laparotomy showed no abno ... | 1978 | 100032 |
| epoxide hydratase and benzo(a)pyrene monooxygenase activities in liver, kidney and lung after treatment of rats with epoxides of widely varying structures. | | 1978 | 103550 |
| homovanillic acid in human csf: comparison of fluorimetry and gas chromatography-mass spectrometry. | | 1978 | 103678 |
| [studies on staphylococcal enterotoxin b. 1. quantitative assay by capillary tube single diffusion test (author's transl)]. | a method for rapidly identifying and quantitating small amount of staphylococcal enterotoxin b was developed on capillary tube single diffusion test. the high sensitivity of method has the advantages to save antiserum and incubation period. some factors such as concentration of antigen and antiserum, incubation temperature, buffer systems, and position of capillary tube all might affect the test accuracy. if all those affecting factors were concerned, the toxin would probably be standardized. th ... | 1978 | 103693 |
| [susceptibility testing with the autobac system (author's transl)]. | the autobac i provides an automated method for the rapid measurement of antimicrobial susceptibility of fast growing pathogenic microorganisms. to check instrument accuracy, 477 cultures were tested by the bauer-kirby method for comparison. according to the din limits, the results were comparable in 81.8%, whereas within the nccls limits the agreement was 86.5%. the discrepancy was found to be due to incorrect disc mass and different limits of inhibitory zone diameters. another reason for disagr ... | 1978 | 103806 |
| synergism between chlorhexidine and sulphadiazine. | | 1978 | 103874 |
| trans-stilbene oxide: a new inducer of rat liver microsomal udp-glucuronyltransferase. | | 1979 | 106858 |
| cell-mediated and humoral immune responses of cattle to brucella abortus, mycobacterium bovis, and tetanus toxoid: evaluation of immunization and assay techniques. | a concentration of 2.5 x 10(-5) m 2-mercaptoethanol (2-me) added to the medium in lymphocyte blastogenesis assays increased both the uptake of [3h]thymidine in unstimulated lymphocyte cultures and the probability of detecting antigen-sensitized cattle. the use of 2-me did not cause lymphocytes from unsensitized cattle to react positively in blastogenesis assays. a crude brucella lysate prepared from brucella abortus strain 19 was compared with a well-characterized brucella protein allergen prepa ... | 1978 | 104645 |
| activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog. | the action of bepridil (5 mg/kg), perhexilene (5 mg/kg) propranolol (0.5 mg/kg), dipyridamole (0.5 mg/kg), amiodarone (10 mg/kg), pentaerythritol tetranitrate (40 microgram/kg) and nitroglycerine (40 microgram/kg) on cardiovascular manifestations of auditory-inducted emotional stress has been investigated in the conscious dog. bepridil, perhexilene and propranolol considerably reduce tachycardia provoked by the anxiogenic stimulus, with nitroglycerin exerting an attenuated effect and the others ... | 1978 | 104675 |
| high affinity uptake sites for taurine in the retina. | | 1978 | 104877 |
| bronchial mucosal permeability. | the tracheobronchial epithelium has well-developed tight junctions which on a morphologic basis should be markedly resistant to penetration by protein molecules. despite this, antigen inhalation in monkeys allergic to ascaris suum results in the rapid onset of pulmonary physiologic changes. recent studies in man and animals have shown that a substantial number of mast cells exist in the bronchial lumen and epithelium. we suggest that antigen-antibody interaction initially occurs on these superfi ... | 1979 | 104888 |