| secondary prevention trials for coronary artery disease with antibiotic treatment for chlamydia pneumoniae: design issues. | | 1999 | 10539871 |
| conclusions. | | 1999 | 10539877 |
| turkeys are protected from infection with chlamydia psittaci by plasmid dna vaccination against the major outer membrane protein. | plasmid dna expressing the major outer membrane protein (momp) of an avian chlamydia psittaci serovar a strain has been tested for its ability to raise an immune response and induce protection against challenge with the same serovar. a combined parenteral (intramuscular injection) and mucosal route (dna drops administered to the nares) of dna inoculation was compared with gene gun-based immunization. the gene gun delivery of pcdna1/momp as well as the intramuscular-intranasal dna delivery primed ... | 1999 | 10540159 |
| fulfillment of koch's postulates and the causes of atherosclerosis. | | 1999 | 10539872 |
| differences in the immune response against ruminant chlamydial strains in a murine model. | cba/j mice were used in the present study to establish differences between the immune response to three chlamydial strains: ab7 (chlamydia psittaci wild-type strain), 1b (c. psittaci vaccinal strain) and ib1 (c. pecorum). the evolution of chlamydial infection was evaluated in each strain by studying the clinical signs, the number of bacteria isolated from the spleen and the pathology of the liver. three aspects of the immune response were then studied: the characterization of the infiltrate of l ... | 1999 | 10543384 |
| in vitro activities of gemifloxacin (sb 265805, lb20304) against recent clinical isolates of chlamydia pneumoniae. | we compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of chlamydia pneumoniae. gemifloxacin was the most active quinolone tested, with a mic at which 90% of the isolates are inhibited and a minimal bactericidal concentration at which 90% of strains tested are killed of 0.25 microg/ml, but this activity was less than those of doxycycline and erythromycin. | 1999 | 10543770 |
| how to design studies to confirm a link between bacterial infection and atherosclerosis. | | 1999 | 10539873 |
| design of future intervention studies for chlamydia pneumoniae in atherosclerosis. | | 1999 | 10539875 |
| chlamydia pneumoniae, asthma, and copd: what is the evidence? | reading this article will familiarize the reader with (1) the unique chlamydial intracellular life cycle and the propensity for human chlamydial infections to become persistent and to result in immunopathologic (inflammatory) damage in target organs and (2) current evidence linking chlamydia pneumoniae (cpn) infection to obstructive lung diseases (asthma and chronic obstructive pulmonary disease, copd). potential therapeutic implications of the cpn-asthma association are also discussed. | 1999 | 10541419 |
| analysis of the humoral immune response to chlamydia pneumoniae by immunoblotting and immunoprecipitation. | chlamydia pneumoniae is a widely spread agent of respiratory tract infections in humans. a reliable serodiagnosis of the disease is hampered by the poor knowledge about immunodominant antigens in c. pneumoniae infections. we applied a novel strategy to identify immunogenic proteins of c. pneumoniae tw183 combining metabolic radiolabeling of de novo-synthesized chlamydial antigens with immunoprecipitation. by this technique c. pneumoniae antigens of approximately 160, 97 to 99, 60 to 62, 40, 27, ... | 1999 | 10548570 |
| can an antibiotic (macrolide) prevent chlamydia pneumoniae-induced atherosclerosis in a rabbit model? | there is increasing data implicating chlamydia pneumoniae in the pathogenesis of atherosclerosis, and antibiotics may theoretically be useful to prevent secondary vascular complications. three groups of new zealand white specific-pathogen-free rabbits, fed cholesterol-free chow, were inoculated via the nasopharynx on three occasions, 2 weeks apart, with c. pneumoniae. group i (n = 23) rabbits were untreated; group ii (n = 24) rabbits were treated with azithromycin at 30 mg/kg of body weight dail ... | 1999 | 10548582 |
| sézary t-cell activating factor is a chlamydia pneumoniae-associated protein. | we previously identified a protein that was stimulatory for malignant sézary t cells, termed sézary t-cell activating factor (saf). however, the identity of this protein has not been fully elucidated, nor has it's role been determined in the pathogenesis of cutaneous t-cell lymphoma (ctcl). the basis for epidermotropism and proliferation of malignant cells in the skin of patients with ctcl is unknown. using a monoclonal antibody inhibitory for saf activity, we demonstrated that saf is present in ... | 1999 | 10548583 |
| chlamydia pneumoniae eradication from carotid plaques. results of an open, randomised treatment study. | to determine the effect of specific antibiotic treatment with roxithromycin in the eradication of chlamydia pneumoniae from carotid artery plaques. | 1999 | 10550273 |
| the possible role of infections in acute myocardial infarction. | cardiovascular diseases, particularly coronary heart disease (chd) and myocardial infarction (mi), are among the leading causes for morbidity and mortality in industrialized countries [2, 77]. during the past decades, various clinical or lifestyle risk factors for myocardial infarction such as hyperlipidemia, hypertension, obesity, lack of physical exercise and smoking have been identified. however, it is also recognized that these well-documented risk factors do not sufficiently account for all ... | 1999 | 10554674 |
| circulating chlamydia pneumoniae dna as a predictor of coronary artery disease. | to determine whether current vascular chlamydia pneumoniae (cpn) infection as diagnosed by circulating cpn dna is more common in subjects with coronary artery disease (cad). | 1999 | 10551689 |
| chlamydia pneumoniae dna detection in peripheral blood mononuclear cells is predictive of vascular infection. | abdominal aortic aneurysm tissue and peripheral blood mononuclear cells (pbmc) of 41 consecutive subjects undergoing abdominal aortic aneurysm surgery were analyzed by polymerase chain reaction (pcr) for the presence of chlamydia pneumoniae, mycoplasma pneumoniae, and helicobacter pylori dna. twenty patients (49%) were positive for c. pneumoniae dna-16 (39%) in both pbmc and aneurysm tissue, 3 (7.3%) in pbmc only, and 1 (2.4%) in the artery specimen only. previous exposure to c. pneumoniae was c ... | 1999 | 10558974 |
| chlamydia pneumoniae in abdominal aortic aneurysms: abundance of membrane components in the absence of heat shock protein 60 and dna. | in this article, we describe the results of a comparative study for the detection of chlamydia pneumoniae in abdominal aortic aneurysm specimens of 19 patients through the use of immunocytochemistry (icc), in situ hybridization (ish), and polymerase chain reaction (pcr), along with the detection of cytomegalovirus (cmv) and herpes simplex virus (hsv) by icc and pcr. c pneumoniae-specific membrane protein was detected in specimens of all 19 (100%; 95% confidence interval [ci] 82% to 100%) and of ... | 1999 | 10559011 |
| chlamydia pneumoniae infection and coronary artery disease. | | 1999 | 10551690 |
| activity of quinolones against chlamydia pneumoniae. | quinolones are currently being used as empirical therapy for the treatment of community-acquired pneumonia and other respiratory infections as they cover a broad range of conventional bacterial and 'atypical' pathogens, including chlamydia pneumoniae. c. pneumoniae has been associated with 10 to 20% of community-acquired pneumonia in adults and recently has been implicated as being associated with several nonrespiratory conditions, including atherosclerosis. however, data on the treatment of eve ... | 1999 | 10553711 |
| enhancement of antibody responses by dna immunization using expression vectors mediating efficient antigen secretion. | the immune responses elicited in mice, after intradermal (i.d.) immunization with plasmids encoding secreted or intracellular forms of hiv-1 nef, hiv-1 tat or c. pneumoniae omp2 proteins, respectively, were compared. to mediate secretion of these proteins the genes were fused to a heterologous signal sequence from murine heavy chain igg. the nef- and omp2-specific antibody responses were dramatically increased when mice were inoculated with the plasmid encoding the secreted form of these protein ... | 1999 | 10556549 |
| molecular diagnosis of chlamydia pneumoniae infection. | | 1999 | 10565886 |
| [chlamydiae--still new surprises]. | a review on participation of chlamydiae in the origin of the hiv-infection, carcinoma and atherosclerosis. the antibodies against the newly discovered pgp3 protein of c. trachomatis were found in 83-87% of the seropositive hiv patients. the participation of c. trachomatis in the etiology of cervical and ovarian carcinoma has been discussed in a number of articles. simultaneous examinations along different lines allow the hypothesis, that c. trachomatis acts as a cofactor in the development of ov ... | 1999 | 10566217 |
| [can or should acute asthma exacerbations be treated with macrolides?]. | | 1999 | 10562668 |
| chlamydia pneumoniae and atherosclerosis. | | 1999 | 10560368 |
| failure to detect chlamydia pneumoniae in brain tissues of alzheimer's disease. | | 1999 | 10563652 |
| the role of chlamydia in coronary heart disease-fact or fiction? | | 1999 | 10570071 |
| in-vitro activity of gatifloxacin against chlamydia trachomatis and chlamydia pneumoniae. | we compared the activity of gatifloxacin, a new quinolone, ofloxacin and erythromycin against five isolates of chlamydia trachomatis and 20 isolates of chlamydia pneumoniae, including tw183 and clinical isolates from the usa and japan. testing was done in cycloheximide-treated hep-2 cells. gatifloxacin was slightly less active against c. trachomatis and slightly more active against c. pneumoniae than ofloxacin, with mics at which 90% of the isolates had no inclusions and minimal chlamydicidal co ... | 1999 | 10588319 |
| [respiratory tract infections triggering bronchial asthma attacks--with special reference to the involvement of chlamydia pneumoniae]. | | 1999 | 10590540 |
| antibiotic use and risk of myocardial infarction. | | 1999 | 10591378 |
| chlamydia pneumoniae and atherosclerosis. | | 1999 | 10591391 |
| relation of c pneumoniae antibodies to ischaemic heart disease. why were samples weakly positive for igg antibodies not tested for iga antibodies? | | 1999 | 10591734 |
| [towards chlamydia pneumoniae vaccination]. | | 1996 | 10592967 |
| [association between chlamydial infection and coronary artery disease]. | recent epidemiological studies have demonstrated the association between chlamydia pneumoniae infection and coronary atherosclerosis. however, the relationship is less clear in the japanese population. serum iga and igg antibodies to chlamydia-specific lipopolysaccharide were measured by enzyme-linked immunosorbent assay in 152 consecutive patients(112 males, 40 females, mean age 57 years)who underwent coronary angiography. patients(n = 123)with coronary artery disease(cad)were defined as having ... | 1999 | 10579134 |
| [chlamydia pneumoniae--a pathogen with cardiovascular significance]. | | 1999 | 10605419 |
| [persistence of chlamydia pneumoniae in coronary plaque tissue. a contribution to infection and immune hypothesis in unstable angina pectoris]. | there is an increasing number of pointers towards a causative connection between chlamydia pneumoniae and atherosclerosis. but the pathogenetic mechanism and intimal structures that are involved remain unclear. starting with the hypothesis of a chronic infection, as demonstrated by the presence of the chlamydial stress (heat-shock) protein 60 (hsp 60), the presence and localization of these bacterial products in coronary atheromas was investigated. | 1999 | 10605420 |
| multiplex pcr for rapid and differential diagnosis of mycoplasma pneumoniae and chlamydia pneumoniae in respiratory infections. | a duplex polymerase chain reaction (pcr) was developed for the simultaneous detection of chlamydia pneumoniae and mycoplasma pneumoniae. a study of 163 respiratory specimens from in-patients of the "centre hospitalier et universitaire de nancy" showed the good sensitivity of this duplex pcr allowing the detection of c. pneumoniae and m. pneumoniae from 8 and 13 patients, respectively, whereas the culture was negative for c. pneumoniae for all the samples and positive for m. pneumoniae only in 9 ... | 1999 | 10579089 |
| characterization of low-density lipoprotein uptake by murine macrophages exposed to chlamydia pneumoniae. | exposure to chlamydia pneumoniae is correlated with atherosclerosis in a variety of clinical and epidemiological studies, but how the organism may initiate and promote the disease is poorly understood. one pathogenic mechanism could involve modulation of macrophage function by c. pneumoniae. we recently demonstrated that c. pneumoniae induces macrophages to accumulate excess cholesterol and develop into foam cells, the hallmark of early atherosclerotic lesions. to determine if c. pneumoniae-indu ... | 1999 | 10602673 |
| computational analysis of the polymorphic membrane protein superfamily of chlamydia trachomatis and chlamydia pneumoniae. | whole sequence genome analysis is invaluable in providing complete profiles of related proteins and gene families. the genome sequences of the obligate intracellular bacteria chlamydia trachomatis and chlamydia pneumoniae both encode proteins with similarity to several 90-kda chlamydia psittaci proteins. these proteins are members of a large superfamily, c. trachomatis with 9 members and c. pneumoniae with 21 members. all polymorphic membrane protein (pmp) are heterogeneous, both in amino acid s ... | 1999 | 10587946 |
| serological evidence of chlamydia pneumoniae lipopolysaccharide antibodies in atherosclerosis of various vascular regions. | the role of chlamydia pneumoniae in the pathogenesis of atherosclerosis has so far mainly been investigated in patients suffering from coronary heart disease; the other vascular regions have virtually been ignored. the aim of this study was to carry out a statistical survey of serological markers of a c. pneumoniae infection in patients with different patterns of atherosclerosis manifestation. | 1999 | 10611843 |
| severe meningoencephalitis: an unusual manifestation of chlamydia pneumoniae infection. | | 2000 | 10619758 |
| chlamydiosis in pen-raised bobwhite quail (colinus virginianus) and chukar partridge (alectoris chukar) with high mortality. | in a flock of 12,000 bobwhite quail (colinus virginianus) and 7200 chukar partridge (alectoris chukar), the owner had 100% morbidity and 40%-50% mortality in birds between the ages of 2 and 4 wk. affected birds were stunted and anorexic and had yellow/green diarrhea. two- and 4-wk-old birds submitted for necropsy all had slight nasal discharge. histopathologic examination revealed mild (bobwhite) to severe (chukar) rhinitis. immunohistochemistry was positive for chlamydia psittaci in all birds. ... | 1999 | 10611999 |
| [chlamydia pneumoniae and asthma]. | | 1999 | 10614091 |
| does chlamydia pneumoniae play a role in the pathogenesis of multiple sclerosis? | | 2000 | 10628821 |
| acute glomerulonephritis associated with pneumonia: a possible chlamydia pneumoniae etiology? | | 1999 | 10618895 |
| chronic infections and coronary heart disease. | the rapidly changing patterns of coronary heart disease (chd) prevalence and presentation fail to be explained by conventional cardiovascular risk factors alone. an infectious basis to atherosclerosis may, at least in part, be contributing to the variable rates of prevalence of chd in different parts of the world. the evidence for such an association appears to be strongest for chlamydia pneumoniae. results of recent anti-chlamydia antibiotic intervention pilot studies have renewed interest in t ... | 1999 | 10622075 |
| [images in medicine. pseudo-tumoral form of chlamydia psittaci pneumonia]. | | 1999 | 10627228 |
| the role of chlamydia pneumoniae in cardiovascular disease. | | 2000 | 10635048 |
| [the studying of chlamydia pneumoniae in atherosclerosis]. | | 1999 | 10635643 |
| the progression of lower limb atherosclerosis is associated with iga antibodies against chlamydia pneumoniae. | to study the influence of serologically diagnosed chronic infection with chlamydia pneumoniae on the progression of lower limb atherosclerosis in a group of disposed men. | 1999 | 10637151 |
| failure to detect chlamydia pneumoniae in the central nervous system of patients with ms. | | 2000 | 10636169 |
| seropositivity to chlamydial lipopolysaccharide and chlamydia pneumoniae, systemic inflammation and stable coronary artery disease: negative results of a case-control study. | we investigated the association between seropositivity to chlamydial lipopolysaccharide (clps) or chlamydia pneumoniae (cp) and angiographically documented coronary artery disease (cad), and we examined the relationship between serostatus and markers of systemic inflammation. | 2000 | 10636268 |
| association of serology with the endovascular presence of chlamydia pneumoniae and cytomegalovirus in coronary artery and vein graft disease. | chemotherapeutic treatment for patients with symptomatic coronary artery disease to reduce cardiovascular events may be initiated in response to elevated antibody titers against chlamydia pneumoniae or cytomegalovirus. how antibody titers are associated with the endovascular presence of these microorganisms is still unclear. | 2000 | 10637199 |
| [acute respiratory chlamydia pneumoniae infections in adults. value of direct gene amplification diagnosis]. | chlamydia pneumoniae has been established recently as an important human respiratory pathogen. the aim of this study was to define the incidence of chlamydia pneumoniae in acute respiratory infections by evaluating its presence in posterior nasopharyngeal aspirates or broncho-alveolar lavage specimens by polymerase chain reaction-hybridization (pcr-eia) as well as the titres of specific antibodies in serum by a relisa test and a micro-immunofluorescence (mif) test. 68 adults patients were invest ... | 1999 | 10637911 |
| helicobacter pylori, chlamydia pneumoniae, and cytomegalovirus: chronic infections and coronary heart disease. | we conducted a medline search of the english-language literature from 1966-1999 on the association of chronic infections with helicobacter pylori, chlamydia pneumoniae, and cytomegalovirus (cmv) with coronary heart disease (chd); additional literature was retrieved from references of selected articles. all human studies were included. abstracts were excluded because of limited data. chronic infections in chd are speculated to be due to serum antibody concentrations of one or more of the three or ... | 2000 | 10641975 |
| [chlamydia pneumoniae and atherosclerosis]. | there is widespread consensus that atherosclerosis is an inflammatory disease. between possible pathogenetic mechanisms, infective hypothesis has received increasing attention. researches have recently focused their attention on the role of chlamydia pneumoniae, a gram-negative intracellular organism, as infection by this bacterium has been demonstrated frequently associated with atherosclerosis. this review attempts to analyze and critically evaluate available data of the literature about the a ... | 1999 | 10638018 |
| identification of an antigen localized to an apparent septum within dividing chlamydiae. | the process of chlamydial cell division has not been thoroughly investigated. the lack of detectable peptidoglycan and the absence of an ftsz homolog within chlamydiae suggest an unusual mechanism for the division process. our laboratory has identified an antigen (sep antigen) localized to a ring-like structure at the apparent septum within dividing chlamydial reticulate bodies (rb). antisera directed against sep show similar patterns of antigen distribution in chlamydia trachomatis and chlamydi ... | 2000 | 10639437 |
| acquired immunity to chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge. | the role of gamma interferon (ifn-gamma) in a chlamydia pneumoniae mouse model was studied by in vivo neutralization in two inbred mouse strains. during primary c. pneumoniae infection, neutralization of ifn-gamma increased both the numbers of bacteria and the pneumonia score in the lungs of c57bl/6 mice but not balb/c mice. during reinfection, the bacterial counts in the lungs were increased by ifn-gamma neutralization in both mouse strains. thus, the effect of ifn-gamma neutralization was depe ... | 2000 | 10639472 |
| pyoderma gangrenosum and chlamydia pneumoniae infection in a diabetic man: pathogenic role or coincidence? | chlamydia pneumoniae is not a known cause of skin infections, but unusual pathogens cause chronic infections in diabetic patients. multiple idiopathic pyoderma gangrenosum-like (pg-like) lesions were refractory to multiple therapeutic agents in a diabetic patient who had c pneumoniae identified by serologic tests and polymerase chain reaction. based on complete resolution by prolonged anti-chlamydial antibiotic therapy and concomitant decrease in serologic and titers determined by polymerase cha ... | 2000 | 10642692 |
| newer pediatric pathogens. | newer laboratory techniques have allowed the detection of previously unrecognized microbial agents that are now pathogenic in children, as well as newly recognized manifestations of previously known pathogens. clinical reports of these newer agents or manifestations are reviewed so that pediatricians can become familiar with these emerging infectious diseases. physicians need to consider these organisms in the differential diagnosis in appropriate clinical illnesses. | 1999 | 10645465 |
| infections, inflammation, and the risk of coronary heart disease. | the role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. we studied the independent and joint effects of these 2 components on coronary risk. | 2000 | 10645920 |
| food antigens and atherosclerosis. | | 2000 | 10645988 |
| vaccination against infections by chlamydia pneumoniae. | chlamydia pneumoniae is an intracellularly growing bacterium that causes respiratory infections and is strongly associated with atherosclerosis. antibodies against c. pneumoniae are frequently encountered in the adult population, indicating past exposure to the micro-organism. immunity to reinfection is, however, only partial and does not prevent development of sequelae. infections caused by and associated with c. pneumoniae are a major cause of morbidity and mortality world wide. development of ... | 1999 | 10646092 |
| environmental factors in myositis. | | 2000 | 10648055 |
| [role of chlamydia pneumoniae in the pathogenesis of coronary disease]. | several studies have demonstrated an association chlamydia pneumoniae with coronary artery disease, suggesting that infection with c. pneumoniae increases the risk for coronary artery disease by factor 2 or more. since atherosclerosis is considered to be a chronic inflammatory process, these data would fit into the response-to-injury hypothesis of atherosclerosis rather than representing a completely novel concept. several pathomechanisms as increased cytokine synthesis, proliferative and proagg ... | 1999 | 10643056 |
| effect of a mycoplasma hominis-like mycoplasma on the infection of hep-2 cells by the tw-183 strain of chlamydia pneumoniae. | we isolated a mycoplasma hominis-like mycoplasma from a stock culture of chlamydia pneumoniae tw-183 obtained from the american type culture collection and eradicated the contaminant by treating the stock suspension with a nonionic detergent, igepal ca-630. the m. hominis-like mycoplasma neither inhibits nor enhances the infectivity of c. pneumoniae for hep-2 cells. | 2000 | 10655399 |
| failure to detect chlamydia pneumoniae in brain sections of alzheimer's disease patients. | a recent north american study detected chlamydia pneumoniae in 17 of 19 brains of alzheimer's patients and supposed a c. pneumoniae infection to be a risk factor for alzheimer's disease (ad). in this study, we analyzed paraffin-embedded tissue samples of 20 ad patients by nested pcr and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither c. pneumoniae-specific dna nor chlamydial antigens. from our data, the presence of c. pneumoniae in the brains of alzheimer's ... | 2000 | 10655406 |
| [chlamydia pneumoniae infection and mycoplasma pneumoniae infection in pediatric patients]. | we evaluated a total of 1104 pediatric patients with acute lower respiratory tract infection for c. pneumoniae infection and m. pneumoniae infection by serology during july 1995 to december 1998. a microimmunofluorescence test was used for diagnosis of c. pneumoniae infection and a high density particle agglutination test for that of m. pneumoniae infection. acute c. pneumoniae infection was found in 149 patients (13.5%), acute m. pneumoniae infection in 118 patients (10.7%), and dual infection ... | 1999 | 10655676 |
| association of chlamydia pneumoniae infection with diabetic nephropathy. | we evaluated the association of chlamydia pneumoniae (cp) infection with progression of diabetic nephropathy. type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using gellman's criteria. type 2 (34) diabetic patients without nephropathy (normoalbuminuria) and 59 nondiabetics served as control groups. serum igg-antibody against cp was measured using elisa. cp antibody ... | 2000 | 10660220 |
| a novel superfamily of predicted cysteine proteases from eukaryotes, viruses and chlamydia pneumoniae. | | 2000 | 10664582 |
| lack of association between kawasaki syndrome and chlamydia pneumoniae infection: an investigation of a kawasaki syndrome cluster in san diego county. | the etiology of kawasaki syndrome (ks), the leading cause of acquired coronary artery disease in children, is unknown. recent studies have suggested that chlamydia pneumoniae, a common respiratory pathogen associated with an increased risk of heart disease, might lead to ks. | 2000 | 10643845 |
| chlamydia pneumoniae-induced transactivation of the major immediate early promoter of cytomegalovirus: potential synergy of infectious agents in the pathogenesis of atherosclerosis. | both cytomegalovirus (cmv) and chlamydia pneumoniae have been associated with atherosclerosis. cmv is believed to exist in host tissues in a latent state with periodic reactivation. this study was designed to determine whether c. pneumoniae infection stimulates the expression of cmv genes. transactivation of the cmv major immediate early promoter (miep) is essential for viral gene expression and viral replication. hela cells were transfected with a construct containing a reporter gene (chloramph ... | 2000 | 10669378 |
| chlamydia pneumoniae and atherosclerosis: what we know and what we don't know. | | 2000 | 10643855 |
| relation of c pneumoniae antibodies to ischaemic heart disease. finnish study finds significant association between raised igg, but not iga, titres and mortality. | | 1999 | 10651478 |
| [ornithosis--studies in correlation with an outbreak]. | an outbreak of ornithosis with 8 cases of ornithosis pneumonia and 2 lethal complications was investigated in workers in a poultry farm and processing plant and a comparative seroepidemiological study of antigen responses was performed in 3 collectives: no. i: n = 82/87 workers in the processing plant, where the outbreak occurred; no. ii: n = 83 workers in a chicken slaughter-house; no. iii: n = 82 as matched-pair group to collective no. i with the same age and sex, but without occupational risk ... | 1999 | 10666940 |
| lack of correlation between chlamydia pneumoniae antibody titers and adult-onset asthma. | | 2000 | 10669864 |
| [helicobacter pylori, chlamydia pneumoniae, reactive c protein, and cerebrovascular diseases]. | | 1999 | 10670238 |
| acellular components of chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells. | accumulating evidence suggest that infection with chlamydia pneumoniae is associated with atherosclerosis, but the mechanisms involved remain unclear. inflammation is important in the initial phase of atherogenesis, and cytokines are important in the initiation and progression of inflammation. the aim of this study was to assess the capacity of acellular components of c. pneumoniae to stimulate the production of pro-inflammatory cytokines and chemokines. peripheral blood mononuclear cells were s ... | 2000 | 10671210 |
| chlamydia pneumoniae serology, lung function decline, and treatment for respiratory disease. | associations have been reported between chlamydia pneumoniae seropositivity and both acute and chronic obstructive airway diseases. plasma specimens collected between 1979 and 1983 from 1, 773 men 45 to 59 yr of age in caerphilly, south wales, were tested for igg and iga antibodies to c. pneumoniae (tw183) by microimmunofluorescence. subsequent mortality and medication for obstructive airway disease were ascertained at 5-yr follow-up examinations. spirometry was performed at the first and second ... | 2000 | 10673191 |
| characteristics and prognosis of myocardial infarction in patients with normal coronary arteries. | myocardial infarction with angiographically normal coronary arteries (minc) is a life-threatening event with many open questions for physicians and patients. there are little data concerning the prognosis for patients with minc. | 2000 | 10669671 |
| polymorphonuclear neutrophils are necessary for the recruitment of cd8(+) t cells in the liver in a pregnant mouse model of chlamydophila abortus (chlamydia psittaci serotype 1) infection. | the role of polymorphonuclear neutrophils (pmns) in the development of the specific immune response against chlamydophila abortus (chlamydia psittaci serotype 1) infection was studied in a pregnant mouse model involving treatment with rb6-8c5 monoclonal antibody. pmn depletion significantly affected the immune response in the liver, in which the t-lymphocyte and f4/80(+) cell populations decreased, particularly the cd8(+) t-cell population. a th1-like response, characterized by high levels of ga ... | 2000 | 10679002 |
| community-acquired chlamydia pneumoniae pneumonia. | | 2000 | 10669723 |
| selenium and vitamin e effect on antibody production of sheep vaccinated against enzootic abortion (chlamydia psittaci). | the effect of selenium (se) and vitamin e (vit e) on antibody production of sheep vaccinated against chlamydia psittaci (ovis) was investigated. thirty-two sheep, one year old, seronegative to chlamydia infection, vaccinated against enterotoxemia and dewormed were used. injectable sodium selenite (0.1 mg/kg b.w.) was given twice to animals of the first group (gse), with a three week interval. the sheep of the second group (ge) received 1 g vit e each orally, six times at weekly intervals. the an ... | 2000 | 10670702 |
| characterization of in vitro dna binding sites of the euo protein of chlamydia psittaci. | the euo gene of chlamydia is highly expressed early in the developmental cycle, relative to other genes, but continues to be expressed throughout the active growth phases. the precise function of euo protein is not known, but it binds to dna in vitro. in this study, we developed a selection and amplification scheme for identifying chlamydial genomic fragments to which euo preferentially binds in vitro. the scheme involved mixing recombinant euo with a chlamydia psittaci genomic library in a pblu ... | 2000 | 10678946 |
| atherosclerosis, inflammation, and infection. | in recent years, it has been shown that inflammation plays an important role in the pathogenesis of atherosclerosis. activated macrophages, t lymphocytes, and mast cells are present in atherosclerotic plaques, which has led to the notion that the inflammatory response is an immune-mediated process. complicated lesions, moreover, appear to be associated with an increase in the amount of the inflammatory response and in these patients, increased levels of acute phase proteins are present. the appr ... | 2000 | 10685058 |
| [preliminary study on chlamydia pneumoniae pneumonia]. | in order to know the incidence of chlamydia pneumoniae (strain twar) pneumonia and its clinical features, 93 patients with pneumonia and 93 matched patients with non-respiratory diseases were studied. twar antibodies (igg and igm) were detected by microimmunofluorescence (mif) test. the results showed that 19.4% (18 cases) patients with pneumonia were twar pneumonia, in which 10 cases accompanied by bacteria infection and 7 cases being simple twar pneumonia. there were no significant differences ... | 1998 | 10681804 |
| genome sequences of chlamydia trachomatis mopn and chlamydia pneumoniae ar39. | the genome sequences of chlamydia trachomatis mouse pneumonitis (mopn) strain nigg (1 069 412 nt) and chlamydia pneumoniae strain ar39 (1 229 853 nt) were determined using a random shotgun strategy. the mopn genome exhibited a general conservation of gene order and content with the previously sequenced c.trachomatis serovar d. differences between c.trachomatis strains were focused on an approximately 50 kb 'plasticity zone' near the termination origins. in this region mopn contained three copies ... | 2000 | 10684935 |
| chronic infection and coronary artery disease. | on a variety of fronts, chronic infection has been found to be significantly associated with the development of atherosclerosis and the clinical complications of unstable angina, myocardial infarction, and stroke. for the most part, these are still just associations. specific causative relationships on par with that determined between h. pylori and peptic ulcer disease have not yet been established. potential mechanisms whereby chronic infections may play a role in atherogenesis are myriad. in t ... | 2000 | 10685131 |
| [prevalence of chlamydia infections in breeding sows and their importance in reproductive failure]. | to investigate the prevalence of chlamydial infection and their significance for reproductive disorders in sow breeding herds in germany, blood samples of 1493 pigs were taken for a serological survey by enzyme-linked-immunosorbent-assay (elisa). antibodies to chlamydiae were found in 33% of the samples, in all herds investigated responders could be detected. the rate of seropositive animals in different farms varied from 4.3% to 72.7%. the percentage of positive responders in the farms correlat ... | 2000 | 10689792 |
| touchdown enzyme time release-pcr for detection and identification of chlamydia trachomatis, c. pneumoniae, and c. psittaci using the 16s and 16s-23s spacer rrna genes. | three touchdown enzyme time release (tetr)-pcr assays were used to amplify different dna sequences in the variable regions of the 16s and 16s-23s spacer rrna genes specific for chlamydia trachomatis, chlamydia pneumoniae, and chlamydia psittaci as improved tests for sensitive diagnosis and rapid species differentiation. the tetr-pcr protocol used 60 cycles of amplification, which provided improved analytical sensitivity (0.004 to 0.063 inclusion-forming unit of chlamydia species per pcr). the se ... | 2000 | 10699002 |
| emerging risk factors associated with cardiovascular diseases. | | 1999 | 10692662 |
| [infections with chlamydia pneumoniae, helicobacter pylori or cytomegalovirus and atherosclerosis]. | it's known that common risk factors of atherosclerosis can explain only 50% of its etiology. in only 40% patients risk factors modification inhibits progression of atherosclerosis. therefore looking for new risk factors of atherosclerosis is necessary. in recent years the inflammatory-infectious hypothesis of atherosclerosis has been reevaluated. the discovery of heavy infections load in the serum of patients with acute coronary syndromes might suggest a potential immunological mechanism trigger ... | 1999 | 10695364 |
| seroprevalence of chlamydia pneumoniae antibodies in a young adult population sample living in verona. european community respiratory health survey (ecrhs) verona. | the aim of the study was to evaluate the prevalence of antibodies to chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in verona, italy. igg and igm titers were measured by micro-immunofluorescence. igg antibodies, greater or equal to 16, were found in 104/177 (58.8%) men and 76/192 (39.6%) women (p < 0.001). no relationship was found between igg seropositivity, age, social class, education and family size. factors positively associated with igg se ... | 2000 | 10697790 |
| serological evidence of infection with chlamydia pneumoniae is related to the severity of asthma. | there is evidence that infection with chlamydia pneumoniae is associated with asthma of recent onset and that it can influence the severity of asthma. this has led to the suggestion that macrolide antibiotics may be useful in the treatment of asthma in subjects infected with c. pneumoniae. this study examined the association between immunoglobulin (ig)g and iga titres to c. pneumoniae and the severity of asthma. igg and iga antibodies to c. pneumoniae were measured in 619 subjects with asthma (1 ... | 2000 | 10706488 |
| what determines asthma phenotype? respiratory infections and asthma. | | 2000 | 10712377 |
| expression of secretory group iia phospholipase a(2) in relation to the presence of microbial agents, macrophage infiltrates, and transcripts of proinflammatory cytokines in human aortic tissues. | recent seroepidemiological and immunohistochemical studies have demonstrated an association between microbial infections and atherosclerosis. however, the mechanisms underlying this association are widely unknown. in the present study, arterial specimens obtained at autopsy after sudden death were analyzed concerning (1) the presence of chlamydia pneumoniae, cytomegalovirus, herpes simplex virus, and helicobacter pylori; (2) the expression of secretory group iia phospholipase a(2) (spla(2)-iia) ... | 2000 | 10712401 |
| detection of sequence variation in pcr-amplified fragments of omp2 gene from three species of the family chlamydiaceae using agarose gel electrophoresis containing bisbenzimide-peg. | a simple technique providing a means for rapid genetic differentiation of chlamydial strains is described. the technique is based on a single-step sequence-specific separation of pcr-amplified dna fragments by electrophoresis in an agarose gel containing a dna ligand - bisbenzimide-peg. a hypervariable region at the 5' end of the omp2 gene of chlamydiaceae species encoding the 60-kda cysteine-rich outer membrane protein was selected as a target for pcr. the appropriate fragments were amplified f ... | 2000 | 10713423 |
| [chlamydia pneumoniae and arteriosclerosis]. | introduction: the relationship between chlamydia pneumoniae and atherosclerosis has been assessed in several studies. development and conclusions. their results suggest a possible role of chlamydia pneumoniae in the origin and development of the disease, while the actual link between them are still unknown. however, the presence of chlamydia pneumoniae in patients with atherosclerosis could be just a coincidence. | 1999 | 10714290 |
| [chlamydia, atherosclerosis, asthma and ms]. | | 2000 | 10701305 |
| key developments in unstable angina. | | 1999 | 10715869 |
| chlamydia pneumoniae and mycoplasma pneumoniae in children with acute respiratory infection in general practices in the netherlands. | in this retrospective study chlamydia pneumoniae and mycoplasma pneumoniae infections were detected by polymerase chain reaction (pcr) in samples (n = 457) from children presenting with acute respiratory infection to general practitioners during 1992-97. samples were collected in autumn and winter, and from 1994 onwards in spring and summer also. overall, c. pneumoniae and m. pneumoniae were detected in throat or nasal samples by pcr in 3.1% and 2.4% of the cases, respectively. the proportion of ... | 2000 | 10716071 |