| rod and cone sensitivity in destriate monkeys. | photopic and scotopic spectral sensitivity of rhesus monkeys was determined before and after complete removal of the striate cortex. the monkeys were required to choose between a white and a series of monochromatic stimuli distributed throughout the visible spectrum. a modified method of limits was used to determine the psychophysical point of subjective equality at which the colored and white lights were perceived as being equally bright. the preoperative results indicated that the method of te ... | 1975 | 809100 |
| intermanual transfer in the monkey as a function of amount of callosal sparing. | the effects of commissure section, task difficulty and overtraining on the intermanual transfer of tactile learning have been examined. twenty-one rhesus monkeys were allocated to 4 groups. one group was subjected to complete transection of the corpus callosum, massa intermedia and posterior commissure. some of this group also sustained a cerebellar section. a second group received a similar division of the commissures but with part of the posterior body of the corpus callosum left intact. a thi ... | 1975 | 809101 |
| extrageniculate projections to layers vi and i of striate cortex (area 17) in the rhesus monkey (macaca mulatta). | | 1975 | 809109 |
| peroxidase labeled subcortical afferents to pulvinar in rhesus monkey. | | 1975 | 809115 |
| the primate median eminence. i. correlative scanning-transmission electron microscopy. | a combined scanning/transmission electron microscopic (sem/tem) technique was used to analyze the third cerebral ventricle and underlying tissue of the median eminence of 6 mature rhesus monkeys. the same sample of the ventricular wall was subjected to both sem and tem. this technique demonstrates two basic subpopulations of supraependymal cells on the surface of the supraoptic, infundibular and mammillary recesses. type 1 cells are definitely neuron-like in their surface configuration and inter ... | 1975 | 809141 |
| interaction of estradiol and lhrh on lh release in rhesus females: evidence for a neural site of action. | the effects on lh release of infusing luteinizing hormone-releasing hormone (lhrh 80 mug/20 min) into the third ventricle, the pituitary, and the peripheral circulation were compared in spayed rhesus monkeys. within 30 min after iv administration, serum lh concentrations increased to twice to preinfusion levels, and by 120 min declined to original values. intraventricular or intrapituitary infusions of lhrh resulted in similar lh increments, but the peaks occurred somewhat later (70 to 90 min) a ... | 1975 | 809257 |
| analysis of the strength-duration characteristics of the estrogen stimulus for the lh surge in the rhesus monkey. | | 1975 | 809302 |
| the neuroendocrine regulation of lh secretion by estrogens in rhesus monkeys. | | 1975 | 809303 |
| genetic variations in primates. red cell enzymes and serum proteins in macaca mulatta. | blood and serum from 17 macaca mulatta were analysed for haptoglobins, transferrins, 6-phosphogluconate dehydrogenase, adenylate kinase, adenosine deaminase, phosphoglucomutase, acid phosphatase, glucose-6-phosphate dehydrogenase and phosphohexose isomerase. compared to the human pattern, the acph and the ada components of macaques are fast moving; ak, pgm, 6-pgd and g-6-pg have almost uniform and similar electrophoretic mobilities; and the hp, tf and phi show differential mobilities. all these ... | 1975 | 809345 |
| response of sublethally irradiated monkeys to a replicating viral antigen. | temporal effects of exposure to sublethal, total-body x radiation (400 r) on responses to vaccination with attenuated venezuelan equine encephalomyelitis vaccine virus. tc-83, were examined in rhesus monkeys. viremia, often with delayed onset, was prolonged even when irradiation preceded vaccination by 28 days. virus titers were increased, articularly in groups irradiated 4 or 7 days before vaccination. delay in appearance of hemagglutination-inhibition and serum-neutralizing antibody correlated ... | 1975 | 809358 |
| hydatid disease in a mandrill baboon. | hydatidosis has been described in many species of domestic and wild mammals, including primates. among the latter reported to have been infected are rhesus monkeys, orangutans, and savannah and drill baboons. this is a case report of hydatid disease due to echinococcus granulosus in a mandrill baboon (mandrillus sphinx). | 1975 | 809388 |
| meningitis caused by klebsiella spp in two rhesus monkeys. | two adult, female rhesus monkeys (macaca mulatta) became depressed, weak, anorectic, and adipsic. auscultation of the thorax of 1 monkey revealed bilateral harsh rales. neither monkey responded to therapeutic doses of antibiotics, and both died soon after treatment was started. meningitis was demonstrated histologically and pure cultures of multiply antibiotic-resistant klebsiella were isolated from the brains of both monkeys. of 13 clinically normal rhesus monkeys in the same facility, 5 had mu ... | 1975 | 809390 |
| mycobacterium avium infection in three rhesus monkeys. | naturally occurring mycobacterium avium infection in 3 rhesus monkeys was characterized clinically and pathologically by intestinal and lymphoreticular involvement. blood lymphocyte rosette formation and phytomitogen responses were depressed, whereas serum beta and gamma globulin concentrations were increased. slow-growing, acid-fast, nonchromogenic bacilli isolated from lymph nodes taken at necropsy were identified as m avium serotypes 4, 18, and double types 1 and 8. | 1975 | 809392 |
| cerebral tuberculosis in a rhesus monkey. | tuberculosis of the cerebrum was diagnosed in a young adult male rhesus monkey (macaca mulatta). tuberculous granulomas were also found in the lungs, bronchial lymph nodes, liver, and spleen. the affected monkey was the probable index case for 7 other macaca mulatta with tuberculosis. | 1975 | 809394 |
| coccidioidomycosis in a rhesus monkey. | coccidioidomycosis was diagnosed after necropsy of a young adult male rhesus monkey obtained from el paso, tx. clinical signs were confined to the respiratory tract and included tachypnea and dyspnea. radiographic findings included multiple air-filled cavities and evidence of severe diffuse pulmonary disease. pathologic changes were confined to the respiratory tract and were representative of the chronic progressive pulmonary form of coccidioidomycosis. unique features of this case were the mass ... | 1975 | 809398 |
| the influence of compositional variations on bone ingrowth of implanted porous calcium aluminate ceramics. | sixteen ceramic specimens were implanted in the femur of mature rhesus monkeys. the specimens consisted of four groups of a basic calcium aluminate composition with additions of 5, 10, 15 and 20 wt% phosphorous pentoxide (p2o5). the increasing amounts of p2o5 caused variations in the resorption rate, microstructure and surface characteristics of the implant. the influence of these variables on bone and tissue growth within and about the implant was investigated. after sacrifice the ceramic-bone ... | 1975 | 809446 |
| the distribution of catecholamines within the inferior olivary complex of the cat and rhesus monkey. | catecholamine histofluorescence was examined in the interior olivary complex of the cat and rhesus monkey. species-specific patterns of catecholamine-containing varicosities were observed. in the rat, the highest concentration of catecholamine varicosities was seen within the dorsal lamella of the principal nucleus. in contrast, this same portion of the inferior olivary complex appeared void of catecholamine varicosities in the cat and rhesus monkey. in the cat, the highest concentration of vari ... | 1975 | 809490 |
| axonal projections and connections of the principal sensory trigeminal nucleus in the monkey. | to date, anatomical studies of ascending principal sensory trigeminal nuclear (prv) axons in the monkey have been restricted to few incomplete investigations utilizing the marchi method. in the present study total or partial unilateral stereotaxic lesions of prv were made in cebus and rhesus monkeys and analyzed with the aid of a variety of nauta silver impregnation techniques applied to frozen sections. analysis of the fiber degeneration emanating from prv lesions indicates that prv fibers form ... | 1975 | 809492 |
| proliferation gradients in the inner ear of the monkey (macaca mulatta) embryo. | radioautographic studies were conducted on early developmental stages of the inner ear in monkey (macaca mulatta) embryos ranging in age from stage 11 to stage 20 (25 to 39 days' gestation) and labeled for one hour with [3h] thymidine. the most active period of proliferation occurred at stage 13, at which time all regions of the otocyst, including the endolymphatic duct, were heavily labeled. in subsequent stages the dorsal portion of the endolymphatic duct failed to incorporate label, whereas p ... | 1975 | 809493 |
| incidence of acetylcholinesterase in the sarcoplasm of human and chicken muscles. | fifty-nine biopsies of human muscle, 53 of them abnormal, 6 normal, were studied for the histochemical localization of acetylcholinesterase (ache) using frozen sections and light microscopy. in addition to ache which was found at the myoneural and myotendon junction, specific staining was found around the periphery of many fibers from normal and abnormal muscles. moreover, ache activity was found to be high in the sarcoplasm of more than 10% of the fibers from 28 biopsies of abnormal muscle incl ... | 1975 | 809546 |
| intracellular (muscle-fiber) habitat of ancylostoma caninum in some mammalian hosts. | the persistence and precise location of ancylostoma caninum larvae in tissues of vertebrate paratenic hosts and the nature of host responses were studied in mouse, cat, and monkey. mice were infected percutaneously and examined at various intervals up to 260 days after exposure. long-persisting larvae were found only in the muscles. histologic sections revealed that within 4 hr after exposure some larvae had migrated through the skin and had entered individual fibers of the underlying muscles. a ... | 1975 | 809563 |
| progress in rhesus histocompatibility typing resulting from the second international nonhuman primate histocompatibility workshop (1973). | the second international nonhuman primate histocompatibility workshop permitted comparison of rhesus monkey alloantisera developed in various laboratories on a single common panel of related and unrelated monkeys. analysis of the data permits the conclusion that at least nine specificities are recognized by more than one laboratory, including six at the first locus and three at the second locus. | 1975 | 809861 |
| t-lymphocyte levels in the peripheral blood of gamma irradiated rhesus monkeys. | circulating thymus derived (t) lymphocytes were studied in rhesus monkeys exposed to single whole body gamma radiation with doses of 400, 500 and 600 rad. spontaneous lymphocyte rosette assay (e-rosettes) was used to evaluate the level of t-lymphocytes. a decrease in total leukocytes, lymphocytes and t-lymphocytes levels was observed beginning from the 5th day after irradiation and continued for several weeks after radiation. | 1975 | 809865 |
| myxosarcoma in a young rhesus monkey. | a myxosarcoma that arose spontaneously in the ilial region of a young male rhesus monkey grew rapidly and invaded and lysed the pelvic bones. it consisted of large pleomorphic cells, with single or multiple nuclei and dilated rough endoplasmic reticulum, in abundant intercellular matrix. | 1975 | 809897 |
| ozone-induced pulmonary lesions in rats and rhesus monkeys. | | 1975 | 809898 |
| nephrotic syndrome in rhesus monkeys. | | 1975 | 809900 |
| right atrial cardiomyopathy in rhesus monkeys. | | 1975 | 809902 |
| impacts of environmental stress exposure on central nervous functional patterns. a quantitative approach to evoked potential data. | albino rats and rhesus monkeys with chronically implanted electrodes in cortical and subcortical, vasomotory and emotionally relevant brain regions were subjected to psycho-nerval stress (short-term stressful cr learning experiments on rats, long-term environmental stress with disturbances of the diurnal rhythm and social hierarchy on rhesus monkeys). applying average computer techniques and discriminance analyses to evoked potentials (average evoked potentials = aep to standardized optic-acoust ... | 1975 | 809950 |
| establishment of ethanol as a reinforcer for rhesus monkeys via the oral route: initial results. | | 1975 | 810004 |
| hepatic and metabolic effects of ethanol on rhesus monkeys. | rhesus monkeys were tube-fed 100 calories per kg of a liquid diet based on casein in which 41% of the calories were derived from grain alcohol. the alcohol intake was 5.8 g per kg per day. control diets contained isocaloric amounts of glucose. the protein content of the diet was 15% and fat supplied 21% of the calories. after 28 days the animals which had been fed ethanol developed hepatic fatty change and serum l.d.h. levels were elevated. the most striking electron microscopic changes in the a ... | 1975 | 810005 |
| [retinal reactions to intense light. i. threshold lesions. experimental, morphological and clinical studies of pathological and therapeutic effects of laser and white light]. | the effects of intense light produced by an argon laser, a helium-neon laser and a xenon are photocoagulator in the retinas of gray chinchilla rabbits, cynomolgus monkeys, and rhesus monkeys were studied clinically and histopathologically including electron microscopy. an improved experimental set-up was used allowing a very good consistency of the inflicted lesions. threshold lesions were produced in chinchilla rabbits and cynomolgus monkeys by an argon laser and a helium-neon laser. the lesion ... | 1975 | 810008 |
| the development of primordial and definitive amniotic cavities in early rhesus monkey and human embryos. | re-examination of early rhesus monkey and human embryos in the collection of the carnegie institution of washington suggests that the mechanism of amniogenesis in both is basically similar to that of the hedgehog and vespertilionid bats. a primordial amniotic cavity develops by cavitation within the embryonic mass of 10-day rhesus monkey, and 7-day human, blastocysts. this primordial cavity has no relationship initially with the overlying trophoblast, contrary to earlier reports. subsequently, t ... | 1975 | 810017 |
| nutritional and environmental factors affecting gestation length in rhesus monkeys. | forty-five pregnancies in rhesus monkeys maintained in a semioutdoor environment and fed about 1, 2, or 4 g of protein/kilogram of body weight each day in otherwise equivalent diets were observed. the 4-g diet shortened gestation 8.5 days. male infants were carried 6 days longer than females; part of difference can be attributed to their greater birthweight. summer conception produced longer gestation than did winter conception. large mothers carried their infants slightly longer than small ones ... | 1975 | 810020 |
| fetal ingestion and metabolism of amniotic fluid protein. | fetal swallowing, digestion, and utilization of amniotic fluid protein were studied in near-term rhesus monkeys in which 35s-protein, synthesized biologically from 35s-methionine, was injected into the amniotic sac. the half-time of the injected protein in amniotic fluid was 1.1 days, a figure consistent with findings of others that fetal swallowing represents the principal mechanism of clearance of amniotic fluid protein. on delivery at timed intervals up to 7 days after injection, evidence of ... | 1975 | 810026 |
| the effects of laser photocoagulation in the retinal capillaries. | using ruby and argon lasers, we produced multiple lesions on normal rhesus monkey retinas. the clinically used energy levels of both lasers produced identical cellular changes in the retina. neither laser directly produced obliteration of capillaries. however, after the cellular damage in each burn lesion was repaired, we observed delayed degeneration of capillaries in a small segment at the burned areas. the marked reduction of active retinal cells that reduce vascular activity may beneficially ... | 1975 | 810028 |
| changes in tissue glycogen of recovering asphyxiated newborn monkeys. | newborn rhesus monkeys were used to investigate the relation between the duration of total asphyxia and the magnitude of the postasphyctic cerebral glycogen hyper-deposition response. the latter has been observed to occur following episodes of total asphyxia lasting 12.5 min and to be maximal at 12 h into the recovery period. the changes in glycogen contents of other vital organs were also studied. a minimum duration of 9 min of total asphyxia was required for the first elicitation of the cerebr ... | 1975 | 810187 |
| inhibitions of feeding examined in rhesus monkeys with hypothalamic disconnexions. | in rhesus monkeys with knife cuts which disconnected the ventromedial hypothalamus and produced hypothalamic hyperphagia, we have studied a variety of stimuli known to reduce food intake: weight gain, emotionally arousing stimuli, bitter-tasting food, amphetamine, and pre-prandial intragastric infusion of nutrient. we demonstrate that these animals are similar to animals with ventromedial lesions in passing through a "dynamic" phase of overeating and weight gain and then stabilizing their body w ... | 1975 | 810215 |
| amygdaloid projections to prefrontal granular cortex in rhesus monkey demonstrated with horseradish peroxidase. | | 1975 | 810217 |
| spatial and chromatic properties of neurons subserving foveal and parafoveal vision in rhesus monkey. | the response properties of neurons in the region of striate cortex subserving central retina (0 degrees-2 degrees) and in a region of representation of parafoveal retina (4 degrees-7 degrees) were studied in unanesthetized paralyzed macaque monkeys. neurons sensitive to the orientation of the stimulus in the visual field (simple, complex, and hypercomplex), and neurons lacking orientation selectivity (concentric, and a new class termed uniform) were found. in foveal cortex non-oriented cells wer ... | 1975 | 810220 |
| autoregulation of spinal cord blood flow. | the response of scbf to changes in paco2 was tested in rhesus monkeys under normotensive conditions. a sigmoid shaped response was demonstrated. at a paco2 of 10 to 50 mm. hg, scbf remained constant and in the normal range. as the paco2 was raised from 50 to 90 mm. hg, scbf increased. further increases in the paco2 above 90 mm. hg failed to effect further changes in scbf. we conclude from these data that scbf is somewhat less responsive than cbf to changes in paco2. next, the effect of changes i ... | 1975 | 810290 |
| the shift-effect in retinal ganglion cells of the rhesus monkey. | | 1975 | 810361 |
| electron microscopic observations of hypothalami in neonatal rhesus monkeys (macaca mulatta) after administration of monosodium-l-glutamate. | | 1975 | 810365 |
| ocular effects of oral contraceptives. ii. studies in the rhesus monkey. | oral contraceptives were administered cyclically to 96 female rhesus monkeys for 5 years. forty-eight animals received enovid-e and 48 were treated with ovulen at doses 1, 10, and 50 times the human dose. ophthalmic lesions did not occur at any of the dose levels employed. significant fundic lesions, including papilledema, venous dilatation, venous retinal thrombosis, or arterial retinal thrombosis, did not develop in any of the treated animals. | 1975 | 810372 |
| optic nerve circulation and ocular pressure. | rapid, short-lasting elevation of ocular pressure level produces simultaneous reduction in blood-flow rate in the distal 6 mm. of the extraocular portion of the optic nerve of the rhesus monkey as monitored by the heated thermocouple technique. the magnitude of this reduction was very small until intraocular pressure (iop) exceeded 50 mm. hg following which markedly and progressively greater reduction in blood-flow rate occurred at higher iop levels; maximum reduction was reached at iop of 105 m ... | 1975 | 810450 |
| microperoxisomes in retinal pigment epithelium. | microperoxisomes were found to be abundant in the retinal pigment epithelium of the human, rhesus monkey, mice, rats, domestic fowl, and frog by ultrastructural histochemistry. they were rare in other cells of the retina and choroid. these organelles had a granular matrix, ranged in diameter from 0.15 mum to 0.30 mum, and were bound by a single tripartite membrane which often maintained slender connections with the smooth endoplasmic reticulum and other microperoxisomes. they exhibited a positiv ... | 1975 | 810456 |
| comparison of three rocky mountain spotted fever vaccines. | growth of rocky mountain spotted fever (rmsf) rickettsiae in duck embryo cell (dec) cultures and chicken embryo cell (cec) cultures was evaluated. experimental lots of duck embryo cell- and chicken embryo cell-grown rocky mountain spotted fever vaccines and a commercial lot of yolk sac-grown vaccine were compared for protective efficacy in rhesus monkeys. incidence and magnitude of antibody response, febrile response, and rickettsemia, as well as incidence of fatalities, suggested that both cell ... | 1975 | 810494 |
| an ontogenic study of histamine and mast cells in the fetal rhesus monkey. | this study was designed to determine the presence of cell-bound histamine and mast cells, if any, in the lung and skin of nonhuman primate fetuses and neonates. the results indicate that cell-bound histamine can be detected in both tissues of the rhesus monkey fetus by 60 days of gestation, the earliest age examined, at levels that are 2% to 3% of levels present in yearling animals. levels increase markedly during the least 1 1/2 mo of gestation; however, at birth, levels are only 12% to 46% of ... | 1975 | 810507 |
| osseous coagulum: a histologic evaluation. | chronic periodontitis can be successfully simulated in primates by the method employed in this study. osseous defects can be created with a marked degree of similarity to one another and subsequently rendered into chronic lesions for healing-repair studies. the chronic periodontal ossious defects corrected by the osseous coagulum technique and by curettage in the rhesus monkey in this study were repaired by the regeneration of the architecture of the lost tissue. the use of the osseous coagulum ... | 1975 | 810568 |
| metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. | methyldopate, the ethyl ester hydrochloride salt of alpha-methyldopa (alpha-md), is used extensively in the treatment of severe hypertension. we have developed a high-pressure liquid chromatographic assay to determine the plasma-time concentrations of alpha-md after intravenous administration of methyldopate and alpha-md in the monkey in an effort to evaluate the bioavailability of alpha-md and the extent of in vivo hydrolysis of the amino ester to the amino acid. the results establish that in t ... | 1975 | 810574 |
| intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. | ventriculocisternal perfusions with five isotopically labeled drugs were performed in the rhesus monkey and the resultant tissue diffusion concentration profiles in caudate nucleus were analyzed. the periventricular distribution space with respect to perfusate concentration was measured and expressed as microliters per 100 mg wet weight: hydroxyurea = 56; methotrexate = 27; thiotepa = 28; 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) = 64 and cytosine arabinoside greater than 170. the apparent dif ... | 1975 | 810575 |
| functional properties of ganglion cells of the rhesus monkey retina. | three general classes of cells were identified in a sample of 460 cells recorded from all areas of the retina subserving the central 40 degrees of vision in the rhesus monkey. 2. one class (colour-opponent) had sustained colour-opponent responses and concentrically organized receptive fields, in which usually one cone mechanism mediated the centre response and one or two different cone mechanisms mediated the antagonistic surround. a few cells of this class had non-concentric (co-extensive) rece ... | 1975 | 810576 |
| trichromatic colour opponency in ganglion cells of the rhesus monkey retina. | two hundred and eleven colour-opponent ganglion cells were studied in the central 10 degrees of the retina of the rhesus monkey, to determine the inputs which they were receiving from different cone mechanisms. spectral-sensitivity measurements in the presence of neutral and coloured back-grounds showed that 24% of these cells appeared to receive input from all three cone mechanisms. 2. in 3% of the cells, the red-sensitive cone mechanism opposed the blue- and green-sensitive ones. in 18% of the ... | 1975 | 810577 |
| concealed colour opponency in ganglion cells of the rhesus monkey retina. | criteria for distinguishing colour-opponent from spectrally non-opponent cells and identifying colour-opponent subtypes on the basis of the cone inputs they receive, have been examined in ganglion cells of the macaque retina using threshold and suprathreshold stimuli, with and without chromatic adaptation. 2. criteria based on suprathreshold responses were found to be insufficient for distinguishing between opponent and non-opponent cells in one-third of the sample. criteria based on a 560 nm ne ... | 1975 | 810578 |
| a perspective of simian tuberculosis in the united states-1972. | despite the availability of effective control measures, simian tuberculosis continues to be a major colony management problem. in 1972, 909 cases of simian tuberculosis were reported to the center for disease control. most of the cases (838) were in rhesus monkeys (macaca mulatta). the attack rate was higher for animals conditioned by commercial importers prior to sale (6.6%) than for animals received shortly after importation without conditioning (1.2%) . failure to apply control measures effec ... | 1975 | 810589 |
| central noradrenergic regulation of cerebral blood flow and vascular permeability. | anatomical studies employing the immunofluorescence localization of dopamine-beta-hydroxylase [= dopamine beta-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating); ec 1.14.17.1] have demonstrated in brain central noradrenergic nerve fibers on small intraparenchymal blood vessels, including capillaries. this system is distinct from the peripheral noradrenergic system inervating the large extraparenchymal blood vessels. from these anatomical findings ... | 1975 | 810805 |
| lysosomal dysfunction in colonic submucosal macrophages of rhesus monkeys caused by degraded iota carrageenan. | administration of a degraded iota carrageenan in drinking water to rhesus monkeys resulted in storage of carrageenan in colonic submucosal macrophage lysosomes that persisted even after prolonged recovery. this storage was accompanied by alterations in lysosomal function (appearance of cytoplasmic acid phosphatase, failure of hrp laden endocytic vesicles to fuse with the carrageenan laden lysosomes). macrophage necrosis and leukocytic infiltration were also observed. administration of a native ( ... | 1975 | 810808 |
| fenfluramine and n-ethyl amphetamine: comparison of the reinforcing and rate-decreasing actions in the rhesus monkey. | n-ethyl amphetamine hcl (nea) and fenfluramine hcl (meta-trifluoromethyl n-ethyl amphetamine) were evaluated as reinforcers in rhesus monkeys that had been previously trained to press a lever using food presentations and cocaine hcl injections as reinforcers. each daily session consisted of episodic opportunities to obtain reinforcers under a fixed-ratio schedule of 30. a drug period was interpolated between two periods in which lever-press responding was maintained by food presentations. compar ... | 1975 | 810821 |
| dyskinesias elicited by methamphetamine: susceptibility of former methadone-consuming monkeys. | rhesus monkeys with a history of drinking methadone but currently drug-free and control monkeys with no drug history were injected with methamphetamine hydrochloride (2 to 5 milligrams per kilogram of body weight). in six of seven monkeys which had consumed methadone the lowest dose immediately elicited pronounced oral dyskinesias virtually identical to those of human tardive dyskinesia. the control monkeys did not exhibit oral dyskinesias even after prolonged treatment with the highest dose. th ... | 1975 | 810889 |
| simian plasmodium knowlesi malaria: studies of coagulation and pathology. | uniformly fatal simian malaria was induced in ten rhesus monkeys by injection of plasmodium knowlesi. the results of serial studies of platelet and blood coagulation factor levels suggested the occurrence of intravascular coagulation during the last 48 hours of the disease, concurrent with a marked fall in hematocrit levels. fibrinogen survival was slightly decreased (two animals), but quantitative fibrinogen levels were elevated. pathologic studies revealed only minimal evidence of fibrin depos ... | 1975 | 811125 |
| the counting and sizing of spermatozoa from ten animal species using a coulter counter. | accurately calibrated coulter counters, models zb industrial and f, were used to count and size spermatozoa before and after zaponin treatment which lyses accompanying debris, droplets and peripheral sperm cytoplasm. sperm specimens from the cauda epididymis of the rabbit, guinea pig, hamster, rat and mouse were without accompanying particles and could be sized without zaponin treatment. the large acrosome cap of the guinea pig swelled rapidly when the spermatozoa were released into an isotonic ... | 1975 | 811131 |
| cardiorespiratory effects of high positive end-expiratory pressure. | five healthy rhesus monkeys were ventilated with intermittent mandatory ventilation and 20 torr positive end-expiratory pressure (peep) for 8 hours. peep was increased to 25 torr and the monkeys were ventilated for 4 more hours. lactated ringer's solution and human salt-poor albumin were used to expand plasma and extracellular fluid volume throughout the entire period of study. homologous blood was administered to maintain hematocrit at control levels and maintenance fluids were infused to maint ... | 1975 | 811132 |
| adaptive changes in the face of the macaca mulatta monkey following orthopedic opening of the midpalatal suture. | the classical effects of lateral orthopedic stress on the midpalatal suture were confirmed in this study conducted on ten female macaca mulatta monkeys in the mixed dentitional period. the suture was opened with consequent expansion of the maxillary arch, of the intranasal space, and of the palatal vault. there was marked buccal displacement of the upper posterior teeth together with a definite broadening of the entire midface. modest relapse of maxillary expansion and of palatal depth occurred ... | 1975 | 811136 |
| glaucoma-induced changes in the ciliary ganglion. | changes in ciliary ganglion cells are described after the experimental induction of glaucoma in rhesus monkeys. they appear within 12 hours in the form of peripheral displacement or extrusion of the cell nucleus and loss of nissl granules. | 1975 | 811251 |
| relationship between growth of brain and skull of macaca mulatta and its importance for the stereotaxic technique. | an analysis of the brain weight of 196 rhesus monkeys and lateral x-rays of 91 more was made to determine and correct the effect of growth and development on sterotaxic variability. a comparison of body weight to brain weight shows that the brain grows rapidly initially in a linear relationship with body weight and can increase in weight even into adulthood, with a significant amount of variability found throughout its development. the examination of the cranial base and sterotaxic reference poi ... | 1975 | 811323 |
| a comparative study of deep avian foveas. | the foveas of nine avian species, initially selected for the presence of a deep fovea and representing a wide range of eye sizes and ecological habits, were studied with quantitative light microscope techniques. considerable variation was observed in the location and configuration of the avian foveas, although they appeared to be 'convexiclivate' in shape when compared with the fovea of the rhesus monkey. comparisons of foveal cell densities (receptor nuclei and ganglion cells) across species sh ... | 1975 | 811324 |
| hypothalamic supraoptic neurones: rates and patterns of action potential firing during water deprivation in the unanaesthetized monkey. | extracellularly recorded action potentials were obtained from hypothalamic supraoptic neurones in unanaesthetized rhesus monkeys. rates and patterns of firing were studied during an initial control period, during 5 successive days of water deprivation and during 4 further days when drinking water was again available. during water deprivation, plasma osmolarity increased progressively from about 300 mosmoles/kg to about 340 mosmoles/kg; control values were again reached after 3 days of rehydratio ... | 1975 | 811325 |
| autoradiographic evidence for a topographically organized projection from the striate cortex to the lateral geniculate nucleus in the rhesus monkey (macaca mulatta). | | 1975 | 811326 |
| single cell activity in the auditory cortex of the unanesthetized, behaving monkey: correlation with stimulus controlled behavior. | the neural activity of 60 cells in the auditory cortices of two rhesus monkeys was examined in relation to systematic variations in cued reinforcement conditions. subjects were trained on a variant of the auditory reaction time (rt) task. in the final behavioral paradigm monkeys were rewarded for rapid key releases to all tonal stimuli in one reinforcement condition (frequency irrelevant = fi), while in the other stimulus-cued condition (frequency discrimination = fd) releases to certain tonal t ... | 1975 | 811328 |
| effective body water half-life and total body water in rhesus and cynomolgus monkeys. | although body water content and effective water half-life have been determined in several mammalian species, including man, these measurements are not available for sub-human primates to our knowledge. values were therefore determined in a group of rhesus and cynomolgus monkeys. a fairly wide range of water half-life values was found in each of the two species between animals, but there was little variation within animals who had more than one determination over the course of 1 year. mean values ... | 1975 | 811339 |
| studies on gonococcal infection. ii. attachment and fate of gonococci in tissue-culture cells. | neisseria gonorrhoeae 188, type 1, was cultured with monolayers of rhesus monkey kidney (re2) cells. attachment of gonococci to re2 cells occurred from about 2 h after inoculation and appeared maximal by 6 h when stained with crystal violet solution and examined under a light microscope. preferential attachment of gonococci to the perinuclear region of tissue cells could not be demonstrated. enumeration of the colony-forming units revealed that gonococci became rapidly attached to re2 cells, inc ... | 1975 | 811342 |
| gonococcal growth factors in tissue cultures. | growth of neisseria gonorrhoeae in the presence of rhesus monkey kidney (re2) cells containing eagle's minimal essential medium (mem) 'conditioned' by 18-20 h of contact with re2 cells began 3-4 h after inoculation and by 16-20 h had reached a maximum. when 'conditioned' medium (cm) was removed from the tissue cells and replaced with fresh medium a 5-6 h lag period occurred before multiplication of gonococci began and by 16 h growth was also near a maximum. cm removed from tissue cells supported ... | 1975 | 811344 |
| in vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey. | a method for the in vivo determination of cerebral blood volume was tested in 15 adult rhesus monkeys. the technique utilized external residue detection and required the serial measurement of two mean transit times, namely, that of an intravascular tracer, c15o-hemoglobin, and that of a diffusible tracer, h215o. in computing the mean transit time for the intravascular tracer, the conventional hamilton extrapolation of the downslope of the recording obtained for the washout of the tracer from the ... | 1975 | 811413 |
| projections of the medial pulvinar to orbital cortex and frontal eye fields in the rhesus monkey (macaca mulatta). | | 1975 | 811490 |
| the concentration of ascorbic acid in the posterior and anterior chambers of the rhesus monkey (macaca mulatta). | the ascorbic acid concentration in the posterior and anterior chambers of the rhesus monkey (macaca mulatta) eye was determined, and found to be significantly higher in the posterior chamber. monkeys anesthetized with pentobarbital sodium had a higher posterior chamber ascorbic acid concentration than monkeys sedated with phencyclidine. the ascorbic acid diffusion coefficient, calculated from the posterior and anterior chamber data, was 0.0012 min.-1 for monkeys given phencyclidine and 0.0010 mi ... | 1975 | 811583 |
| chromatographic methods for the analysis of hexachlorobenzene and possible metabolites in monkey fecal samples. | the separation and identification of hexachlorobenzene (hcb), pentachlorobenzene (qcb), and pentachlorophenol (pcp) by thin layer, high-pressure liquid, and gas chromatography are reported. satisfactory results were obtained with reverse phase thin layer and high-pressure liquid chromatography. the 2 gas chromatographic columns tested gave adequate separation of hcb and qcb. a pcp methylation process using dimethyl sulfate was attempted. procedures are presented for extraction, cleanup, separati ... | 1975 | 811638 |
| effects of taurodihydrofusidate, a bile salt analogue, on bile formation and biliary lipid secretion in the rhesus monkey. | bile salts play a major role in bile formation and biliary lipid secretion. sodium taurodihydrofusidate (tdhf), a derivative of the antibiotic fusidic acid, closely resembles bile salts in terms of structure, micellar characteristics, and capacity ot solubilize otherwise insolbule lipids. we have therefore studied the biliary secretion of this bile salt analogue and its influence on bile formation and biliary lipid secretion in primates. alert, unanesthetized female rhesus monkeys prepared with ... | 1975 | 811689 |
| effects of one-stage and serial ablations of the middle third of sulcus principalis on delayed alternation performance in monkeys. | recovery of a spatial delayed alternation habit following partial frontal lesions was investigated in mature rhesus monkeys. all animals subjected to serial ablation of the middle third of sulcus principalis were found to be capable of reacquiring preoperative levels of performance on the task. however, one-stage removal of the mid-principalis region resulted in both more severe and more protracted impairments than were evident after serial surgery. these results in conjunction with previous fin ... | 1975 | 811693 |
| isolation of poxvirus from an african rodent. | a poxvirus was isolated from a wild gerbil (tatera kempii) caught in northern dahomey, africa at the time of an epidemic of human smallpox. electron microscopic appearance and serologic reactions placed it in the vaccinia subgroup of poxviruses. the isolate differed from ectromelia, rabbitpox, vaccinia, monkeypox, and cowpox viruses in pock morphology on chorioallantoic membrane, ceiling temperature, relative innocuity for mice, and cytopathic effect in tissue culture. like variola minor virus, ... | 1975 | 811713 |
| clindamycin concentrations in the central nervous system of primates before and after head trauma. | the authors measured levels of clindamycin, a drug well established as useful in the treatment of various soft-tissue and parenchymal bacterial infections, in serum, cerebrospinal fluid, and brain tissue of 14 rhesus monkeys. penetration into brain tissue was erratic and concentrations detected were not significant. cerebrospinal fluid levels, however, averaged 20.5% of paired serum concentrations and were higher than concentrations needed to inhibit most gram-positive bacteria. further studies ... | 1975 | 811766 |
| spinal cord blood flow as affected by changes in systemic arterial blood pressure. | the authors used the hydrogen clearance method to measure focal spinal cord blood flow (scbf) in the rhesus monkey over a wide range of mean arterial blood pressures (map) in an attempt to test the hypothesis of autoregulation. the map was either lowered by bleeding or raised by the intravenous infusion of norepinephrine or angiotensin. the scbf remained constant and in the normal range with an map of 50 to 135 mm hg, indicating the presence of autoregulation. below 50 mm hg, scbf fell passively ... | 1976 | 811767 |
| monkey brain damage from radiation in the therapeutic range. | twelve macaca mulatta monkeys received 200 rads of supervoltage radiation to the whole brain per day, 5 days a week. the course in 4 monkeys was 4 weeks for a total dose of 4000 rads; in 4 monkeys, 6 weeks for 6000 rads; and in 4 monkeys, 8 weeks for 8000 rads. four unirradiated monkeys served as controls. one from each group, sacrificed at 6 and 12 months from start of irradiation, are reported here. the results from 4000 rads were negligible; those from 8000 rads, profound, with gross brain de ... | 1976 | 811769 |
| recovery of schistosomula in the skin of rhesus monkeys immunized with cercariae of schistosoma japonicum exposed to high dose of x-irradiation. | | 1975 | 811784 |
| barbiturate-reinforced responding in rhesus monkeys: comparisons of drugs with different durations of action. | the rate and pattern of pressing a lever was studied in rhesus monkeys under conditions where each press led to the intravenous injection of a barbiturate or of saline. the reinforcing effect of the barbiturate was indicated by higher rates of responding on the lever that delivered drug than on the lever that did not and by lower rates of responding when saline was delivered instead of the barbiturate. responding increased and was maintained by the following ranges of dose/injection: barbital (2 ... | 1975 | 811787 |
| mechanism of immunity of schistosomiasis: histopathologic study of lesions elicited in rhesus monkeys during immunizations and challenge with cercariae of schistosoma japonicum. | | 1975 | 811795 |
| intragastric self-administration of psychoactive drugs by the rhesus monkey. | | 1975 | 811941 |
| visual attention and inferotemporal cortex in rhesus monkeys. | | 1975 | 812002 |
| further comments on the ascorbic acid requirement. | recommended daily allowances (us rda) of the food and drug administration for ascorbic acid are higher than recommended dietary allowances (set by the food and nutrition board) for adults. there is a 6-fold margin between the requirement to prevent scurvy and the us rda. the high requirement reported for the rhesus monkey may be needed to compensate for oxidative catabolism of ascorbic acid in this species. the rate of production of ascorbic acid, in mammals that synthesize it has been listed as ... | 1975 | 812090 |
| primate drinking system as defined by electrical stimulation of the brain (esb). | four rhesus monkeys were examined by esb for drinking sites in structures that had been previously demonstrated to support drinking behavior. three yielded a significantly greater proportion of drinking sites than expected from the earlier study, and one yielded significantly less. as the exploration proceeded, the proportion of sites yielding drinking greatly increased in the drinkers and decreased in the nondrinker, and the ratio of stimulus-bound to nonstimulus-bound drinking sites increased ... | 1975 | 812128 |
| asymmetrical cross-tolerance between morphine and scopolamine induced antinociception in the primate: differential sites of action. | two experiments explored the role of the cholinergic system in mediating morphine induced analgesia in the rhesus monkey. experiment 1 tested for cross-tolerance between two antinociceptive compounds, morphine and scopolamine, using the shock titration technqiue. tolerance to morphine attentuated the response to scopolamine but tolerance to scopolamine had no effect on morphine induced antinociception. in experiment 2, the shock threshold was not modified by injections of scopolamine or arecolin ... | 1975 | 812134 |
| dialyzable transfer factor. | dialyzable transfer factor, obtained from human peripheral blood leukocytes and first described by lawrence, is being used in attempts to rectify defects in the cellular immune systems of patients with basic immunodeficiencies, chronic infectious diseases, and neoplastic diseases. current knowledge of the chemical character of, assays for, and functional activities of transfer factor are briefly reviewed. an experimental animal model for dialyzable transfer factor involving the rhesus monkey (ma ... | 1975 | 812183 |
| platelet aggregates in hypercholesterolemic rhesus monkeys. | | 1975 | 812202 |
| timing of major ontogenetic events in the visual cortex of the rhesus monkey. | the place and time of origin, the migration and eventual disposition of neurons of the monkey visual cortex were studied by autoradiography in animals killed at various intervals after 3h-thymidine pulse labeling at embryonic (e) and early postnatal (p) stages. all neurons destined for the visual cortex are generated during about a 2-month period between e45 and e102. neuron position in the cortical laminae correlates systematically with time of cell origin; neurons destined for deeper cortical ... | 1975 | 812226 |
| age, sex, and experience as related to the neural basis of cognitive development. | studies of rhesus monkeys raised from infancy without portions of the central nervous systems provide evidence regarding the timing of functional maturity of specific regions. some findings have been presented which show that deficits following lesions of specific cortical areas emerge at that age when abilities dependent upon the cortical area in question take on adult form in unoperated monkeys. however, age is but a convenient abstraction for conditions that vary over time. one such condition ... | 1975 | 812229 |
| effects of intense visible radiation on the increment-threshold spectral sensitivity of the rhesus monkey eye. | | 1975 | 812257 |
| miniature eye movements of fixation in rhesus monkey. | | 1975 | 812258 |
| [the effect of depot contraceptive agents on the ovary in rhesus monkeys]. | | 1975 | 812316 |
| the effects of tolbutamide on the development of atherosclerosis in rhesus monkeys fed an average american table-prepared diet. | | 1975 | 812341 |
| 3h2o volume and exchange in uterine cavity of monkeys. | a technique was developed to measure water exchange in the endometrical canal (uterine cavity). this type of determination should provide information necessary to understanding intrauterine pharmacokinetics. in the study described, measurements were performed on one cynomologus and four rhesus monkeys. endometrial fluid in the uterine cavity was replaced with a 3h2o solution of known specific radioactivity (dpm/ml). radioactivity remaining in the cavity at measured intervals of approximately 0.5 ... | 1975 | 812366 |
| effects of chlorpromazine on the vertical chamber syndrome in rhesus monkeys. | in an attempt at social rehabilitation, chlorporomazine was given to three groups of rhesus monkeys that had been confined to the vertical chambers apparatus early in their development. previous studies have shown that such periods of deprivation produce severe deficits in social behavior. there were no substantial beneficial effects of chlorpromazine treatment; however, there was a notable amount of spontaneous improvement seen in all three groups. we discuss these data in terms of their implic ... | 1975 | 812449 |
| [experimental argon-laser trabeculo-puncture in rhesus monkeys]. | | 1975 | 812471 |