| corynebacterium parvum toxicity in patients with limited and advanced malignancy. | the toxicity of intravenously administered corynebacterium parvum was observed in 14 patients with stage ii melanoma and in 14 patients with advanced ovarian carcinoma. those with melanoma were rendered disease-free by surgery prior to treatment. the ovarian cancer patients had failed chemotherapy with alkylating agents and were receiving c. parvum prior to chemotherapy as part of an immunochemotherapy trial. both clinical and laboratory parameters were observed. the mean daily c. parvum dose fo ... | 1984 | 6539697 |
| activation of peritoneal lymphocyte cytotoxicity in patients with ovarian cancer by intraperitoneal treatment with corynebacterium parvum. | following an intensive course of combination chemotherapy, patients with minimal residual ovarian cancer were treated with increasing concentrations of intraperitoneal corynebacterium parvum to assess whether or not natural killer (nk) cells could be activated. immunotherapy was administered every 2 weeks, initially with a dose of 250 micrograms/m2, which was progressively escalated as tolerated. each treatment induced a peritoneal cellular exudate which consisted primarily of neutrophils 48h af ... | 1984 | 6541243 |
| the protective effect of pretreatment with killed corynebacterium parvum against acute babesiosis in calves. | yearling calves were pre-treated intravenously (iv) with a 0.20 mg kg-1 dose of corynebacterium parvum and challenged after 30 days by iv inoculation of 3 x 10(9) babesia bigemina. the relatively low 0.20 mg kg-1 dose of c. parvum enhanced resistance as indicated by lower mean babesia parasitemias and less severe decreases in packed-cell volumes than in non-treated calves, but failed to stimulate a significant (p less than or equal to 0.05) level of protection against b. bigemina challenge. | 1984 | 6541833 |
| the growth and spontaneous dissemination of melanoma b16 and lewis lung tumour in two sub-strains of c57bl/6j mice treated with corynebacterium parvum and/or levamisole. | the effect of c. parvum and/or levamisole on tumour growth and spontaneous dissemination was tested in two tumour-host systems, melanoma b16 and llt in c57bl/6j mice. c. parvum inhibited the growth of llt and its dissemination to the lungs and the growth of b16 in females in one of the two sub-strains of mice used. levamisole stimulated the growth of b16 in females in one sub-strain and in both sexes in the other sub-strain of mice. the growth of llt was not influenced by levamisole but its diss ... | 1983 | 6546203 |
| effect of vaccine prepared from corynebacterium parvum on the growth of gardner lymphosarcoma in c3h strain mice. | the present paper discusses the effect of a vaccine prepared with formol-killed corynebacterium parvum (alias propionibacterium acnes) on the growth of solid gardner lymphosarcoma transplanted on c3h (h-2k) mice. the vaccine was injected at various time intervals prior to, simultaneously with, or following transplantation of the tumor to intact mice or mice immunized with 60co-irradiated gardner tumor cells. the effectivity was evaluated in terms of numbers of mice surviving without tumor 60-day ... | 1984 | 6549499 |
| treatment of c3h mice bearing solid gardner lymphosarcoma with vaccine prepared from corynebacterium parvum combined with methotrexate and alexan. | c3h mice after transplantation of solid gardner lymphosarcoma were injected with methotrexate (mtx) or alexan. the prolonged survival time of mice treated with antimetabolites was in some cases evidently reduced after an additional injection of corynebacterium parvum (c.p.). this reduction did not depend on the sequence of corynebacterial vaccine or mtx injections. significantly better effect of combined treatment with mtx injection and c.p. was found only once in mice preimmunized with the tumo ... | 1984 | 6549500 |
| intratumoral bcg and corynebacterium parvum therapy of canine mammary tumours before radical mastectomy. | in two parallel studies, bitches with mammary tumour received single intralesional injections of bcg (1 mg: 10(7) living bacteria) and corybacterium parvum (10(9) killed bacteria) (53 bitches) or c. parvum alone (129 bitches) at the same dosage. control groups received injections, following the same protocol, of 1 ml bcg suspension medium diluted in saline in the first study (51 bitches) or no injections at all (120 bitches in the second study). a block dissection, including mammary tumours, adj ... | 1983 | 6555059 |
| augmentation of antitumor resistance by a strain of unicellular green algae, chlorella vulgaris. | growth of meth-a tumor in cdf1 mice was inhibited significantly by injection of a hot water extract of a strain of chlorella vulgaris (ce) into the tumor or into the subcutaneous tissue near the tumor. the augmentation of resistance by ce may require the participation of t cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. mice treated with ce exhibited antigen-specific augmented resistance against rechallenge wit ... | 1984 | 6565519 |
| muramyl dipeptide is a powerful potentiator of the antitumor action of various tumor-necrotizing agents. | the previously observed potentiation of necrosis and regression of solid immunogenic meth a sarcoma transplants in mice after iv administration of endotoxin by addition of muramyl dipeptide (mdp) in saline was investigated further by varying time and route of administration of both agents. equal potentiation was observed when mdp was administered 4 h before or after endotoxin, but administration 48 h or 24 h before or 24 h after endotoxin had no effect. simultaneous administration of both agents ... | 1984 | 6566601 |
| the role of immunotherapy in acute myelogenous leukemia. | the use of immunotherapy for acute myelogenous leukemia (aml) is controversial. twenty-four trials have been reported in which 1,491 patients with aml received various forms of immunotherapy, including bcg, methanol extract residue (mer) of bcg, or corynebacterium parvum. some patients were immunized with allogeneic or autologous leukemia blast cells. in only four of the 24 trials was a significant prolongation of remission reported. pooled data from all 24 studies were analyzed further. no stat ... | 1983 | 6577818 |
| chemotherapy and corynebacterium parvum for induction and maintenance of remission in acute myelogenous leukaemia--a controlled study. | | 1983 | 6580265 |
| abortive ectromelia virus infection in peritoneal macrophages activated by corynebacterium parvum. | we have previously demonstrated that peritoneal macrophages (m phi s) from c3h mice were resistant to in vitro infection by ectromelia virus, following activation by intraperitoneal injection of the immunomodulator corynebacterium parvum. in contrast, resident and mineral oil-elicited m phi s were fully susceptible to virus infection. this report analyzes the infectious cycle of ectromelia virus in c parvum-activated and mineral oil-elicited m phi s and demonstrates that an abortive infection oc ... | 1984 | 6584516 |
| macrophages in resistance to rickettsial infections: protection against lethal rickettsia tsutsugamushi infections by treatment of mice with macrophage-activating agents. | peritoneal macrophages of balb/c and c3h/hen mice activated in vivo by intraperitoneal inoculation of viable mycobacterium bovis strain bcg or the nonliving macrophage-activating agent propionibacterium acnes (corynebacterium parvum), were resistant to infection with rickettsia tsutsugamushi, and they killed bacteria that did gain entry into the intracellular environment of these cells. this macrophage resistance to infection and intracellular destruction of rickettsiae was dependent upon develo ... | 1984 | 6584528 |
| comparison of corynebacterium parvum with freund's complete adjuvant as a potentiator of the immune response to beta-human chorionic gonadotropin linked to tetanus toxoid. | corynebacterium parvum was compared with freund's complete adjuvant (fca) for potentiation of the rabbit immune response to beta-human chorionic gonadotropin linked to tetanus toxoid (beta-hcg-tt). with each adjuvant, antibodies to hcg were detected using passive hemagglutination. higher antibody titers were produced by fca-treated animals. the ability of antisera to beta-hcg-tt to neutralize the biological action of native hcg was determined by the rat uterine weight assay. anti-beta-hcg-tt ser ... | 1984 | 6588767 |
| experimental otitis media in guinea pigs. serum antibody response to bacteroides fragilis, propionibacterium acnes and peptostreptococcus anaerobius upon challenge. | the production of antibodies in serum was studied after inoculation of bacteroides fragilis, propionibacterium acnes or peptostreptococcus anaerobius into the middle ear of guinea pigs. inoculation of b. fragilis resulted in igg and igm serum antibodies at an early stage of the infection, while iga antibodies were seldom detected and at a later stage. in contrast, inoculation of p. acnes or p. anaerobius induced no serum antibody response. of these three species b. fragilis induced the most inte ... | 1984 | 6598260 |
| solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat. | cytotoxic capacity of rat macrophages (m phi) and natural killer (nk)/natural cytotoxic cells (nc) against adherent growing, solid tumor-derived target cells was evaluated, modulating the activation status of effector cells and growth conditions of target cells. testing a panel of target cells, cytotoxicity of nk/nc and m phi was strikingly correlated so that besides of target-cell binding structures basic lysability seems to be of influence with respect to cytotoxicity rates. varying the in viv ... | 1983 | 6603412 |
| induction of chemiluminescence during interaction of tumoricidal effector cell populations and tumor cells is dependent on the presence of mycoplasma. | a variety of host cells, such as activated macrophages, natural killer (nk) cells, and polymorphonuclear leukocytes (pmnl), are cytotoxic for an array of non-antibody-coated tumor cells. because such effector cells appear to use oxygen-dependent mechanisms to effect tumor cell destruction in certain systems, the possibility of an involvement of toxic oxygen species has been considered. to investigate whether interaction of effector cells with neoplastic cells induces the generation of reactive o ... | 1984 | 6607953 |
| comparison of antimetastatic effect against lewis lung carcinoma after intratumoral and intravenous injections of cell-wall skeleton of propionibacterium acnes c7 in c57bl/6 mice. | antimetastatic activity of cell-wall skeleton of propionibacterium acnes c7 (p. acnes-cws) in c57bl/6 mice varied depending on the injection route. the kinetics of antimetastatic effect against lewis lung carcinoma (3ll) revealed that the sooner intratumoral (it) injection of p. acnes-cws was carried out, the better the result. however, intravenous (iv) injection of p. acnes-cws produced the best result if p. acnes-cws was injected at about the time when metastases began to develop in the lungs. ... | 1984 | 6609859 |
| the enhancement of tumor cell susceptibility to macrophage binding and cytolysis by p-aminobenzoic acid-n-xyloside sodium salt (k-247). | the enhancement of tumor cell susceptibility to macrophage binding and cytolysis by the pretreatment of tumor cells by p-aminobenzoic acid-n-xyloside sodium salt (k-247) was investigated in the c3h/he mouse-syngeneic tumor system. binding and cytolytic activities of corynebacterium parvum-activated macrophages were significantly enhanced when target mm-102 and mh-134 cells were pretreated with k-247 at doses of 200 or 400 micrograms/ml, while thioglycollate-elicited macrophages showed much lower ... | 1984 | 6609891 |
| models of adoptive t-cell-mediated regression of established tumors. | | 1984 | 6610533 |
| regulation of mopc 104e by t cells and growth factors induced by c. parvum stimulation. | corynebacterium parvum, known for its ability to retard the growth of experimental neoplasms, was examined for its effect on the growth of murine plasmacytoma mopc 104e in vivo and in vitro. immunostimulation with c. parvum resulted in the accelerated growth of mopc 104e in experimental animals, as measured by the tumor igm production. the acceleration of plasmacytoma growth was seen in all cases where c. parvum was given before or at the time of tumor transplantation. increased proliferation of ... | 1984 | 6610653 |
| studies on natural killer cell activity and the influence of corynebacterium parvum on murine t-cell leukemogenesis induced by butylnitrosourea. | butylnitrosourea (bnu) was used to induce thymic lymphomas in bdf1 mice. during and after the 12-week bnu exposure the spontaneous nk cell activity against yac-1 cells and that arising 4 days after stimulation with corynebacterium parvum (cp) were measured, as were the mitogen responses of splenic t and b cells. in addition to bnu, groups of mice received multiple injections of the interferon inducer cp during or after the bnu exposure period. the results show a slight impairment of the nk cell ... | 1984 | 6610680 |
| [a case of spondylodiscitis caused by propionibacterium acnes and peptococcus constellatus]. | | 1983 | 6612203 |
| suppressive effects of corynebacterium parvum on primary and secondary antibody responses in mice. | the splenic plaque forming cell (pfc) response of mice to an intraperitoneal injection of sheep erythrocytes was severely depressed by prior treatment with corynebacterium parvum given four days beforehand by the same route. however, total antibody levels were less affected, and soon attained near normal titres. this implied that the effects of c. parvum were limited to the spleen, and that other tissues gave a substantial response during the period when the splenic response was suppressed. equa ... | 1983 | 6620257 |
| [antigenic relationship between the chemically-induced mouse bladder tumor and corynebacterium parvum]. | | 1983 | 6620769 |
| effects of the removal of the primary tumor and immunotherapy with corynebacterium parvum on metastatic tumor proliferation. | the effects of surgical intervention by removal of the primary focus, and the effectiveness of an immunomodulator, corynebacterium parvum (cp), on the proliferation of metastatic tumor tissue were investigated by following the postoperative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed type hypersensitivity reaction (dth) was studied to investigate the immune capacity of the host. the labelling rate of mic ... | 1983 | 6624533 |
| treatment of advanced ovarian malignancy with chemoimmunotherapy using autologous tumor and corynebacterium parvum. | fourteen patients with advanced ovarian epithelial carcinoma were treated with a combination of chemotherapy and immunotherapy. the chemotherapy consisted of either melphalan or a combination of adriamycin, cytoxan, and cisplatin. the immunotherapy consisted of the injection of autologous radiation-attenuated tumor and corynebacterium parvum. no significant toxicity occurred as a result of the immunotherapy, and there was no evidence of tumor growth at the sites of injection. the autologous tumo ... | 1983 | 6633998 |
| coparvax for malignant effusion? | | 1983 | 6641514 |
| organ distribution of tritium labeled corynebacterium parvum in mice. | | 1983 | 6645221 |
| [corynebacterium acnes osteitis. a case in a child]. | the authors report a case of corynebacterium acnes osteitis in an 11 year old girl, involving the upper of the right tibia. the lesion resembled a malignant tumour radiologically and tuberculosis histologically. scintigraphy revealed involvement of the seventh right rib. 3 months treatment with pristinamycin resulted in cure. | 1983 | 6646947 |
| protection of cattle against theileria annulata infection using corynebacterium parvum. | four groups of calves (a, b, c and d) each consisting of five calves were used for the present study. group a calves were given corynebacterium parvum alone. group b calves were inoculated with inactivated ground-up-tick supernate (guts) prepared from hyalomma anatolicum anatolicum infected with theileria annulata plus c. parvum. group c received only inactivated guts. all the surviving calves of groups a to c were exposed on day 45 post-inoculation to a lethal tick challenge along with suscepti ... | 1983 | 6649060 |
| growth of propionibacterium acnes strains on semisynthetic medium; antigenic polysaccharide production. | a semisynthetic medium, containing yeast extract as the only non defined component and glucose, glycerol, tween 80 and mineral salts, has been developed to grow the strains of propionibacterium acnes beck 2037, gerrath 2038 and vogel 2039, at a rate comparable to that of complex media. an average of 10(12) cells per 1 (equivalent to approximately 1.5 g/l dry weight) was usually achieved. these yields are appropriated for biochemical and immunological studies, e.g. cell wall preparation, polysacc ... | 1983 | 6649955 |
| the influence of endotoxin in vitro on hepatic macrophage lysosomal enzyme release in different rat models of hepatic injury. | since bacterial endotoxin is known to be involved in the pathogenesis of hepatic injury, the influence of endotoxin on lysosomal enzyme production by hepatic macrophages has been investigated. macrophages have been isolated from the livers of normal rats, from the livers of rats given stilboestrol subcutaneously 4 days previously and from the livers of rats given corynebacterium parvum intravenously 6 days previously. following isolation and overnight culture, the macrophages have been maintaine ... | 1983 | 6651924 |
| acute polyarthritis following the use of corynebacterium parvum vaccine (coparvax) for malignant pleural effusion. | a 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of corynebacterium parvum vaccine for pleurodesis. within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs. | 1983 | 6657546 |
| response of tumors to biologic modifiers and chemotherapeutic agents. | the use of the fanft model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. we studied c. parvum and glucan immunotherapy of fanft tumors, and demonstrated the enhancement of tumor growth following glucan administration. weekly injections of cyclophosphamide (cy) retarded tumor growth and increased survival. combining c. parvum or glucan with cy resulted in greater tumor growth inhibition than cy alone. our data support the concept ... | 1983 | 6658848 |
| [mechanism of the antitumor immunity potentiated by anaerobic corynebacterium parvum]. | | 1983 | 6662469 |
| effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. all three species were capable of growth at 100% air saturation but at reduced growth rates. the presence of oxygen altered the production of extra-cellular enzymes. propionibacterium avid ... | 1983 | 6663280 |
| [etiological investigation of propionibacterium acnes variant isolated from children with kawasaki disease]. | | 1983 | 6663741 |
| [current trends in immunotherapy of tumors of the lung]. | | 1983 | 6675558 |
| [the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum on metastatic tumor proliferation]. | the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum (cp) on the proliferation of metastatic tumor tissue were investigated by using autoradiography to follow post-operative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed hypersensitivity reaction and the cytotoxicity (adcc, nk) of lung cells were studied, to investigate the immune capacity of ... | 1983 | 6676630 |
| changes in anatomical distribution of tumour lesions induced by platelet-active drugs. | to examine the effect of platelet-active drugs on the spread of blood-borne tumour cells, two murine tumours, sarcoma 180 (s-180) and tlx-5 lymphoma, were selected. following intravenous (iv) injection into cba mice the former elicited thrombocytopenia and formed discrete pulmonary tumours, whereas the latter failed to elicit thrombocytopenia and formed discrete tumours in all visceral organs examined except the lungs. s-180 cells were injected iv into mice pre-treated with ra233 (known to preve ... | 1983 | 6677619 |
| effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. | the effect of the immunostimulant c. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. male swiss albino mice were injected intra-venously with m. arthritidis culture and intraperitoneally with c. parvum. it was shown that mice immunostimulated with c. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. however, when the arthritis was established c. parvum had no effect on ... | 1983 | 6678690 |
| in vitro activity of u-57930e against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline. | the in vitro activity of u-57930e, a pipecolic acid amide of clindamycin, was compared with those of clindamycin, ampicillin, carbenicillin and tetracycline against 321 anaerobic clinical isolates. the mic (micrograms/ml) of u-57930e that inhibited 95% bacteroides fragilis, peptococcus prevotii, b. melaninogenicus and p. asaccharolyticus was 0.0625; 0.03125 for peptostreptococcus anaerobius, b. vulgatus, propionibacterium and peptococcus species. clindamycin, on the other hand, gave mic values o ... | 1983 | 6678915 |
| new therapeutic approaches to treatment of malignant gliomas: chemotherapy and immunotherapy. | | 1983 | 6680086 |
| non-specific immunization against bovine tropical theileriosis (theileria annulata) using killed corynebacterium parvum. | killed corynebacterium parvum was used as an adjuvant for the production of non-specific resistance against theileria annulata in cattle. groups of cross-bred (bos indicus x bos taurus) calves were administered c. parvum adjuvant subcutaneously and were then challenged with t. annulata-infected ticks on 45, 60 or 90 days later. the challenge caused mild reactions in the protected calves. none of the 10 immunized calves died due to theileriosis, whereas all three paris of susceptible control calv ... | 1983 | 6685397 |
| tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | the physiologically occurring tetrapeptide, tuftsin (thr-lys-pro-arg), was examined for its effects on guinea pig peritoneal macrophages. adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) m, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation product, thromboxane b2 (txb2), was studied. tuftsin causes both albumin-elicited and c. parvum-activated møo to set free superoxide anion (o2) and hydrogen peroxide (h2o2). it also st ... | 1983 | 6687720 |
| difficulties in producing antibodies to purified propionibacterium acnes exocellular enzymes. | attempts were made to produce antisera to purified preparations of propionibacterium acnes lipase, hyaluronate lyase and acid phosphatase in rabbits. antiserum to lipase (neutralizing titre i:32) was produced using conventional methods. lipase (30 micrograms) in freund's complete adjuvant (fca) was injected into multiple sites thrice at weekly intervals. antibody levels were boosted by i.v. injections of 30 micrograms in saline at 2-weekly intervals for 2 months. such regimes failed to raise ant ... | 1984 | 6691919 |
| the bacterial flora of the forehead and back of alaskan native villagers in summer and in winter. | the bacterial flora of the forehead and back of eskimo and indian villagers in arctic alaska was determined in midsummer and in winter (temperature -29 degrees to -46 degrees c). specimens collected by the wet swab method were transported overnight, chilled, to seattle in buffered diluent with triton x-100. control tests showed good survival of principal skin organisms with moderate or large initial populations and a disproportionately greater loss with an initial sparse population. results of t ... | 1984 | 6699430 |
| variably acid-fast bacteria in a fatal case of hodgkin's disease. | | 1984 | 6703743 |
| immunotherapy with biochemically dissociated fractions of propionibacterium acnes in a murine ovarian cancer model. | the antitumor effect of two strains of propionibacterium acnes (pai and paii) and chemically derived fractions from the whole bacterial cell were studied using a murine ovarian teratocarcinoma (mot) model. when injected i.p. in high doses (700 to 1400 micrograms/mouse), both strains produce survival of a significant proportion of tumor-bearing mice (30 to 90%). on a weight to weight basis, however, pai was significantly more effective than paii. pai and paii were extracted using pyridine, which ... | 1984 | 6713388 |
| the adverse effect of pregnancy on macrophage activation. | recently a remarkable decrease in the resistance to infection with listeria monocytogenes and toxoplasma gondii in pregnant mice was demonstrated. since activated macrophages are important in the resistance against these organisms, studies were performed to determine whether pregnancy has an adverse effect on the activation of macrophages and effector functions of these macrophages. peritoneal macrophages from normal pregnant and virgin mice or from pregnant and virgin mice previously injected w ... | 1984 | 6713543 |
| effect of pregnancy on augmentation of natural killer cell activity by corynebacterium parvum and toxoplasma gondii. | studies were performed to determine the effect of pregnancy on nk cell activity and the augmentation of nk cell activity which normally follows injection of killed c. parvum or live t. gondii. when compared to cells from virgin mice, peritoneal and splenic cells from unstimulated pregnant mice showed no significant difference in nk activity. in contrast, nk activity of peritoneal cells from pregnant mice that received c. parvum or t. gondii was significantly lower than that found in comparably t ... | 1984 | 6715884 |
| enhancement of thermal response of normal and malignant tissues by corynebacterium parvum. | further studies were carried out on the combined effects of corynebacterium parvum and hyperthermia on animal tissues and cultured chinese hamster ovary cells. experimental animals were c3hf/sed mice derived from our defined flora mouse colony. tumors were eighth-generation isotransplants of a spontaneous fibrosarcoma, fsa-ii. hyperthermia was given by immersing the mouse foot or culture flasks in the constant temperature water bath. present experiments include thermal enhancement of c. parvum a ... | 1984 | 6722772 |
| photoinactivation of propionibacterium acnes by near-ultraviolet light. | photodestruction of propionibacterium acnes was investigated by broad-band near-ultraviolet light. the inactivation of the bacteria was found to be oxygen dependent, and without o2 practically no photoinactivation occurred. d2o caused an increased inactivation (d10 = 5 kj/m2 in d2o as compared to d10 = 11 kj/m2 in normal water). decreased temperature during illumination increased the ability to form colonies. the results are compared with corresponding results for other types of cells and the de ... | 1984 | 6730638 |
| changes in the bacterial flora of the external ear canal from the wearing of occlusive equipment. | external otitis has been associated with wearing obstructive gear covering the earlobe and external ear canal. in this study we investigated the changes in the bacterial flora of the external ear canal after wearing rubber hoods. the bacterial flora of external ear canals surfaces was investigated in a group of 19 volunteers who wore rubber hoods for a period of 25 to 30 minutes while doing manual work. the protective effect of 2% acetic acid was tested by instilling it in the left ear of all pa ... | 1984 | 6738278 |
| comparative bacteriology of chronic blepharitis. | one hundred and fifteen patients with chronic blepharitis were compared with 47 normal controls. six clinically distinct groups of blepharitis were observed: staphylococcal; seborrhoeic, alone, with associated staphylococcal superinfection, meibomian seborrhoea, or secondary inflammation of the meibomian glands; and meibomian keratoconjunctivitis (mkc). staphylococcus aureus was isolated in appreciable frequency from the staphylococcal and the mixed staphylococcal/seborrhoeic groups in contrast ... | 1984 | 6743618 |
| acetic, propionic, and oleic acid as the possible factors influencing the predominant residence of some species of propionibacterium and coagulase-negative staphylococcus on normal human skin. | the minimum inhibitory concentration (mic) of acetic and propionic acid for resident bacteria on normal human skin, such as propionibacterium acnes and staphylococcus epidermidis, was 25 mg/ml or more at any ph tested (ph 5.5-6.8). while the mic of these acids for most of the transient bacteria was markedly decreased by lowering the ph of the media and at ph 5.5, the mean ph value of the normal human skin, the mic was 6.25 mg/ml or less. the mic of oleic acid for some strains of gram-positive tr ... | 1984 | 6744125 |
| differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor. | sera from mice infected with plasmodium yoelii or plasmodium berghei and given endotoxin contained nonspecific mediators which killed both species of parasite and tumor cells in vitro. the sera resembled tumor necrosis sera obtained from mice given macrophage-activating agents such as propionibacterium acnes (formerly designated corynebacterium acnes) or mycobacterium bovis bcg and then endotoxin. cytotoxicity developed parallel to parasite killing activity and indicated that macrophages were ac ... | 1982 | 6752029 |
| the use of an anaerobic incubator for the isolation of anaerobes from clinical samples. | an anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. seventy specimens were selected as likely to yield anaerobes: 342 different anaerobes were isolated in the incubator and 347 in anaebrobic jars. these included bacteroides spp (43%), peptococcus spp (26%), peptostreptococcus spp (13%), veillonella spp (7%), fusobacterium spp (7%), clostridium spp (2%) and miscellaneous gram-positive nonsporing bacilli (2%). differences in isolati ... | 1982 | 6752210 |
| development of a bioassay for anti tumor activity of biological response modifiers of the reticuloendothelial stimulant class: reproducibility of the bioassay. | intravenously administered diluzio glucan, wellcome c. parvum, and glaxo bcg caused dose dependent increases in the tumor cell loss from the lungs of c57bl/6j and dba/2j mice challenged respectively with intravenous 125iudr labelled b16 or t 1699 mammary carcinoma cells. the results were reproducible with respect to the optimal doses and the magnitudes and shapes of the dose response curves. | 1981 | 6752286 |
| methotrexate alone or with regional subcutaneous corynebacterium parvum in the treatment of recurrent and metastatic squamous cancer of the head and neck. | patients with advanced, incurable squamous cancer of the head and neck were randomly assigned to treatment with weekly methotrexate alone or methotrexate with corynebacterium parvum given subcutaneously in weekly bilateral doses in sites around the neck. the addition of c. parvum did not alter the response rate, response duration, survival (either median or long-term) or severity of toxic effects compared to treatment with methotrexate alone. response rates were higher for patients without dista ... | 1982 | 6754063 |
| comparative aspects of cancer immunotherapy: immunologic methods used for treatment of spontaneous cancer in animals. | | 1982 | 6757216 |
| bacteriologic and serologic investigation in diffuse sclerosing osteomyelitis (dso) of the mandible. | an attempt was made to clarify the obscure origin of diffuse sclerosing osteomyelitis (dso) of the mandible. bacteriologic investigations of specimens from diseased mandibles were performed with special attention to anaerobic culture technique. propionibacterium acnes and peptostreptococcus intermedius were in some patients found to be of etiologic importance. sampling techniques and associated problems are discussed. an examination was made for antibodies in the patients' sera against antigens ... | 1982 | 6757825 |
| histologic observations of coccoid forms suggestive of cell wall deficient bacteria in cutaneous and systemic lupus erythematosus. | the cutaneous lesions of seven consecutive patients with cutaneous lupus erythematosus (le), two patients with systemic le, and a patient with both dermatomyositis and cutaneous le, were studied bacteriologically and microscopically for the presence of bacteria. the study was prompted by the previous reports of variably acid-fast and non-acid-fast bacteria in other collagen diseases, and also by recent reports confirming the presence of cell wall deficient (cwd) bacteria (staphylococci, streptoc ... | 1982 | 6759425 |
| maintenance of the normal flora of human skin grafts transplanted to mice. | full-thickness human cadaver skin was maintained on the dorso-lateral thoracic region of hairless mice whose immune rejection mechanism was suppressed using anti-mouse-thymocyte globulin. the bacterial profile of the pregrafted skin did not differ significantly from the normal human microflora. in contrast, the murine skin exhibited quantitative and qualitative differences from the human flora, in particular by the complete absence of propionibacterium acnes, the dominant bacterium on sebum-rich ... | 1982 | 6759614 |
| [clinical effectiveness and immunological control of the immunochemotherapy of acute leukemia in children using a corynebacterium parvum preparation]. | | 1982 | 6760108 |
| a cell surface marker expressed on cytotoxic peritoneal macrophages and normal lung macrophages. | | 1982 | 6760695 |
| antitumor effect of heat-killed aspergillus fumigatus mycelium in a mouse model. | a suspension of heat-killed aspergillus fumigatus mycelium inhibited the growth of a chemically-induced mouse bladder tumor (mbt). tumor growth was inhibited when the mycelium was injected into mice in a mixture with the tumor cells, when injected into growing tumors, and when introduced ip at the time tumor cells were injected into the hind leg muscle. in the concentrations that affected tumor growth no toxicity of the fungus preparation was observed. the fungal suspension was more effective ag ... | 1982 | 6760960 |
| shunt nephritis associated with propionibacterium acnes with demonstration of the antigen in the glomeruli. | | 1982 | 6762506 |
| effects of corynebacterium parvum on escherichia coli infection in mice. | the contribution of activated macrophages to protection against escherichia coli was studied in mice. mice treated intraperitoneally with killed corynebacterium parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with e. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. however, treatment with c. parvum 4 d prior to challenge induced mainly activated macrophages in the peritoneal cavity and hos ... | 1982 | 6763935 |
| [numerical taxonomy of gram-positive anaerobic bacilli]. | numerical taxonomy's techniques were employed on twenty one anaerobic gram positive bacilli strains taking account of eighty morphologic and biochemical features. two methods of coding (weighted and non weighted) and four clustering methods (unweighted pair-group method using arithmetic averages; weighted pair-group method using arithmetic averages; single linkage and complete linkage) were used. eight dendrograms were obtained and they showed that c. haemolyticum (strains 1, 2, 4, 7); c. subter ... | 1982 | 6765620 |
| decreased resistance to listeria monocytogenes in mice injected with killed corynebacterium parvum: association with suppression of cell-mediated immunity. | to investigate the therapeutic potential of killed corynebacterium parvum, its effects on the course of listeria monocytogenes infection in mice was studied. mortality in mice given c. parvum after l. monocytogenes infection was greater than in mice given c. parvum before infection or infected with only l. monocytogenes. c. parvum alone resulted in no mortality. spleens from infected mice given c. parvum had increased numbers of l. monocytogenes. peritoneal macrophages from mice infected with on ... | 1980 | 6767792 |
| [metronidazole sensitivity of anaerobes. a comparison with other chemotherapeutics (author's transl)]. | in comparative in vitro studies, broad spectrum penicillins and cephalosporins showed a relatively weak action in the range of beta-lactamase-positive bacteroides species (b. fragilis, b. thetaiotamicron) bacteroidaceae activity being otherwise good. clindamycin was more effective against bacteroides species than against bacteria of the fusobacterium-sphaerophorus group. metronidazole, however, showed no gap in its efficacy against bacteroidaceae, peptococcaceae and clostridium spp. with the exc ... | 1980 | 6771559 |
| the use of immunopotentiators in malaria. | | 1980 | 6772589 |
| mycotic aneurysm of the pulmonary artery complicating ventriculoatrial shunt. | | 1980 | 6773348 |
| immunotherapy of the guinea pig line 10 hepatocarcinoma with a variety of nonviable bacteria. | a variety of heat-killed bacteria were tested for their capacity to induce regressions of established line 10 hepatocarcinomas in syngeneic guinea pigs. multiple intralesional injections of heat-killed escherichia coli, streptococcus mutans, listeria monocytogenes, and propionibacterium acnes resulted in complete regression of the tumor in a majority of guinea pigs. repeated injections of heat-killed mycobacterium bovis strain bacillus calmette-guérin caused no regressions. surviving animals wer ... | 1980 | 6775802 |
| relationship between non-specific activity of macrophages and immune responses to listeria monocytogenes. | delayed footpad reactions and acquired cellular resistance to listeria monocytogenes were studied in mice whose mononuclear phagocyte system (mps) had been blocked or stimulated. colloidal carbon was used for the blockade of mps and corynebacterium parvum used for the stimulation. strong delayed footpad reactions. on the other hand, the i.v. injection of 3 x 10(1) listeria induced an appreciable level mice, while in mps-stimulated mice, i.v. injection with even 4 x 10(3) listeria could not induc ... | 1980 | 6776031 |
| differentiation and production of colony-stimulating factor induced by immunostimulants in a leukemia cell line. | immunostimulants from various microorganisms were tested on a myeloid leukemia cell line (m1) for the ability to induce production of csf and to cause differentiation of these cells. based on their activities, the compounds were divided into two general classes: those inducing extensive cellular differentiation and those devoid of this effect. the stimulants which were active in this regard always produced large quantities of csf, whereas those devoid of a differentiating effect did not cause cs ... | 1980 | 6776132 |
| the effects of corynebacterium parvum in dogs and a study of its distribution following intravenous injection. | | 1980 | 6777166 |
| antibody coated bacteria in otitis media with effusions. | the significance of bacterial isolates of coagulase negative staphylococcus epidermidis and corynebacterium species in middle ear fluids remains controversial. this study was undertaken to evaluate the possible role of these organisms in different effusions. cultures were obtained from the external cartilaginous ear, bony canal, tympanic membrane, middle ear fluids, tonsils and nasopharynx of 93 patients at the time of myringotomy for otitis media with effusion. isolates of coagulase negative st ... | 1980 | 6778287 |
| microbiology of otitis media. | the microbiology of otitis media (om) has been documented by cultures of middle ear fluid (mef) obtained by needle aspiration. the results of studies of bacteriology of om from sweden, finland and the united states are very similar: streptococcus pneumoniae and haemophilus influenzae are the most important pathogens: gram-negative enteric bacilli are isolated from mef of approximately equal to 20% of infants to six weeks of age but are rarely present in mef of older children; group a beta hemoly ... | 1980 | 6778362 |
| kinetic parameters of lactate dehydrogenases of some rumen bacterial species, the anaerobic ciliate isotricha prostoma and mixed rumen microorganisms. | a number of kinetic parameters of the lactate dehydrogenases of three rumen bacterial species (peptostreptococcus productus, propionibacterium acnes and actinomyces viscosus), the rumen ciliate isotricha prostoma and mixed rumen microorganisms (mrm) with respect to nadh, pyruvate, fructose-1,6-diphosphate (fdp) as well as the effects of several nucleotide phosphates were studied. partially purified ldh of peptostr. productus had the same kinetic parameters as in crude cell free extracts. values ... | 1980 | 6778389 |
| [immunomodulators]. | a comprehensive picture of the most well-known immunomodulators has been drawn, focussing the attention on their immunopharmacological profile and their prospective clinical use. besides, the cell targets of the immunologically active agents are also considered. the role of cyclic nucleotides in the mechanisms of immune regulation as well as the importance of the host characteristics in this connection are carefully analyzed. some general considerations are finally set forth on the usefulness of ... | 1980 | 6779825 |
| inhibition of lipase production in propionibacterium acnes by sub-minimal-inhibitory concentrations of tetracycline and erythromycin. | | 1981 | 6786318 |
| in vitro cytotoxicity expressed by cells active against established tumors in vivo. | although antitumor activity by host cells has been documented in vivo and in vitro, the cellular relationships between these two classes of studies are not clear. cells capable of causing the regression of solid tumors are generated in lymph nodes draining sites of immunization with corynebacterium parvum:irradiated p815 mastocytoma admixtures. these cells are active in a 51cr release assay at a low effector:target ratio producing a characteristic low level of specific 51cr release which require ... | 1981 | 6788359 |
| phagocytic and chemiluminescent responses of mouse peritoneal macrophages to living and killed salmonella typhimurium and other bacteria. | in the presence of luminol, resident as well as thioglycolate-induced and immunized macrophages emitted chemiluminescence more efficiently when the cells were exposed to living salmonella typhimurium than when they were exposed to the same bacterium killed by ultraviolet light or heat. this phenomenon was observed whether or not the bacterium was opsonized. the different response to living and killed bacteria was also found with escherichia coli, pseudomonas aeruginosa, proteus morganii, and ent ... | 1981 | 6788707 |
| prostaglandins and host defense in cancer. | | 1981 | 6792432 |
| [effect of the age of the mouse on the action of corynebacterium parvum in inhibiting the growth of 2 syngenetic tumors]. | the antitumor properties of corynebacterium parvum have been studied in mice of different ages of two inbred strains: xvii mice and c3h mice grafted with syngeneic tumors. the antitumor protection was very weak in young mice: no effect on mortality rate, only an increase in mean survival time was observed. the highest level of protection was obtained in 2-5 month old mice (100% of survival) in aged mice this antitumor protection decreases more rapidly in c3h mice than in xvii mice. it is interes ... | 1981 | 6794870 |
| [inhibitory effect of arginine butyrate on the development of crocker 180/tg tumor in swiss mice]. | arginine butyrate slightly increases the resistance of swiss mice to allografted 180/tg tumor cells. a single injection of corynebacterium parvum has comparable effects. however, it they are associated, survival rate is significantly augmented. | 1981 | 6797689 |
| resting macrophages produce distinct metabolites from exogenous arachidonic acid. | resident mouse peritoneal macrophages rapidly metabolize free arachidonic acid (20:4) in the absence of a discernible trigger. after a 20-min incubation in serumless medium, one-third of the fatty acid was found esterified in cell phospholipid and two-thirds was metabolized to oxygenated products which were recovered in the culture medium. the 20:4 oxygenated metabolites were identified by reverse-phase high performance liquid chromatography as hydroxyeicosatetraenoic acids (hetes) and 6-keto pr ... | 1982 | 6799609 |
| regulation of arachidonic acid metabolism by macrophage activation. | levels of zymosan-induced arachidonic acid (20:4) metabolism by peritoneal macrophages elicited with inflammatory agents and resident macrophages were similar. thyioglycollate (thio)-elicited macrophages represented the exception; however, the diminished metabolism by these cells was reproduced by exposing resident cells to 5 mg/ml thio broth in vitro. in contrast, reduced prostaglandin synthesis by macrophages from mice variously treated with the immunologic agents, corynebacterium parvum or ba ... | 1982 | 6801185 |
| analysis of the soluble cytoplasmic components of mycobacteria and nocardia by crossed immunoelectrofocusing. | soluble cytoplasmic components of mycobacterium tuberculosis, strain h 37 ra, and washington ii, mycobacterium bovis, strain bcg and nocardia asteroides were analysed by isoelectric focusing, crossed immunoelectrophoresis, and crossed immunoelectrofocusing. using con a-affinity chromatography con a-reactive polysaccharides could be separated from the cytoplasmic fraction which improved the focusing effect. the isoelectric focusing patterns of the various mycobacterial strains were similar, howev ... | 1982 | 6805157 |
| dispersal of non-sporeforming anaerobic bacteria from the skin. | dispersal of non-sporeforming anaerobic bacteria was studied. skin samples were taken from the subjects, and dispersed from different parts of the body was examined. the number of anaerobic bacteria dispersed was not correlated to their density on the surface of skin area exposed. the highest density of anaerobic bacteria on the skin was found in the face and upper trunk, but the highest yield of anaerobic bacteria dispersed came from the lower trunk. the dominant anaerobic bacteria dispersed we ... | 1982 | 6806353 |
| nonspecific resistance to infection expressed within the peyer's patches of the small intestine. | intraperitoneal or intraduodenal pretreatment of mice with dead corynebacterium parvum failed to produce significant nonspecific resistance to salmonella enteritidis infection in the peyer's patches of the small intestine. however, mice pretreated with a single oral infection of live listeria monocytogenes were capable of restricting the growth of s. enteritidis in the peyer's patches. the ability of l. monocytogenes to induce nonspecific resistance was associated with the ability of this organi ... | 1982 | 6809636 |
| activation of components of the alternative pathway of complement by propionibacterium acnes cell wall carbohydrate. | the trichloroacetic acid (tca) extractable molecules in propionibacterium acnes cell wall were tested for the ability to activate the alternative pathway of complement in human serum treated with ethyleneglycol-bis (beta-aminoethyl ether) n,n-tetracetic acid (egta). the extracted molecules failed to consume hemolytic activity against antibody-coated sheep erythrocytes but gave a dose-dependent consumption of rabbit erythrocyte (re) lytic activity. similarly, the extract produced significant clea ... | 1982 | 6809840 |
| structures and biological activities of peptidoglycans of listeria monocytogenes and propionibacterium acnes. | the cell-wall skeletons of listeria monocytogenes strain egd and propionibacterium acnes strain c7, which have the ability to induce macrophage activation, were analyzed, and the structures of the peptidoglycans were investigated. the analytical data indicate that both peptidoglycans have glucosamine residues with free amino groups, which are responsible for the resistance to lysozyme. possible structures of these peptidoglycans were deduced from the composition and the results of determination ... | 1982 | 6811573 |
| regulatory interactions between macrophages and t-cell subsets in listeria monocytogenes-specific t-cell activation. | peritoneal exudate t lymphocytes from listeria monocytogenes-immune mice in the presence of the homologous antigen (heat-killed l. monocytogenes) and normal macrophages showed l. monocytogenes-specific proliferative responses. proliferation was inhibited by macrophages from l. monocytogenes- or corynebacterium parvum-pretreated mice as well as by exogenous prostaglandin e(2). macrophage-dependent inhibition of t-cell proliferation-at least in part-could be reversed by addition of indomethacin. w ... | 1982 | 6818150 |
| [antimicrobial action of benzoyl peroxide]. | | 1982 | 6821331 |
| cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ara-c. | studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with corynebacterium parvum revealed that their effect on the emt-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. in additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on emt-6 target cells. | 1980 | 6821557 |
| dose-dependent macrophage stimulation by corynebacterium parvum. | corynebacterium parvum (c. parvum) administered at a dose of either 0.1, 1 or 10 mg/kg intraperitoneally (ip) to bdf1 mice was evaluated for its influence on peritoneal exudate cell differentials, numbers, respiration, phagocytic activity and capacity and intracellular microbicidal activity. the ip administration of 1 mg/kg of c. parvum resulted in a 2-3 fold increase in the yield of peritoneal exudate cells 1-5 days after injection; 0.1 mg/kg was ineffective, while 10 mg/kg of c. parvum manifes ... | 1980 | 6821558 |