| acute thyroiditis in a patient with q fever. | | 1966 | 5951280 |
| rickettsioses (tick typhus, q-fever, urban typhus) in malaya. | | 1966 | 5951938 |
| quantitative assay of coxiella burnetii in mice. | experimental data are presented which demonstrate that the complement-fixing antibody response in individual mice can be used for quantitative assay of coxiella burnetii. the method allows the replacement of a single guinea pig with a single mouse, thus resulting in considerable savings in caging requirements and animal costs. | 1966 | 5970463 |
| [immunity in guinea pigs vaccinated simultaneously with live brucellosis and q fever vaccines]. | | 1966 | 6004841 |
| [attenuated variants of rickettsia burneti and several prospects for their use in live vaccines against q fever]. | | 1966 | 6004845 |
| [study on q fever in são paulo. iv. follow-up of non-reacting animals in infected herds]. | | 1966 | 6010138 |
| [clinico-epidemiological studies on recent cases of q fever]. | | 1966 | 6010537 |
| [allergic cutaneous reactions to rickettsia burneti in young adults. development in relation to time]. | | 1966 | 6014077 |
| [on the study of the effect of the feeding of ornithodoros papillipes ticks on rickettsia burneti in their organism]. | | 1966 | 6015032 |
| [on q fever rickettsial inflammation (local reaction in guinea pigs in subcutaneous infection with rickettsia burneti]. | | 1966 | 6015033 |
| [local reaction of the perintoneum in experimental q fever in guinea pigs (on the problem of q fever rickettsial vasculitis]. | | 1966 | 6015034 |
| physiology of rickettsiae. vi. host-independent synthesis of polyribonucleotides by coxiella burnetii. | preparations of purified and disrupted suspensions of coxiella burnetii are able to incorporate ribonucleotides into polymers in the presence of adenosine, guanosine, cytidine, and uridine triphosphates. nucleotide incorporation requires the presence of all four ribonucleoside triphosphates. the reaction is enhanced by the addition of phosphoenolpyruvate and pyruvic kinase, and exogenous deoxyribonucleic acid, and is inhibited by deoxyribonuclease and actinomycin d. incorporation is maximal betw ... | 1967 | 6025413 |
| physiology of rickettsiae. vii. amino acid incorporation by coxiella burnetii and by infected hosts. | protein synthesis, in terms of (14)c-labeled amino acid incorporation into a hot trichloroacetic acid fraction, was studied in cell-free preparations of coxiella burnetii, and in uninfected and q fever-infected guinea pig and chick embryo hosts. purified and disrupted suspensions of c. burnetii incorporated (14)c-labeled l-leucine, l-phenylalanine and algal hydrolysate. livers of infected guinea pigs and chick embryos had a greater incorporation rate at the height of infection than comparable pr ... | 1967 | 6025436 |
| electron microscopic observations of coxiella burnetii in the guinea pig. | | 1967 | 6027996 |
| combined epidemic typhus and q-fever vaccine: adjuvant effect of coxiella burneti. | | 1967 | 6042428 |
| interaction of rickettsiae and phagocytic host cells. v. phagocytic and opsonic interactions of phase 1 and phase 2 coxiella burneti with normal and immune human leukocytes and antibodies. | | 1967 | 6051387 |
| q fever immunity in man. | | 1967 | 6061374 |
| [q fever]. | | 1967 | 6064769 |
| [focus of q fever in gdansk in 1962]. | | 1967 | 6068852 |
| is kawasaki disease a variant of q fever? | | 1980 | 6105313 |
| interaction of rickettsiae with haemocytes of alveonasus lahorensis ticks. | the development of different rickettsial species (rickettsia sibirica, r. conorii, r. acari and coxiella burnetii) in haemocytes of alveonasus lahorensis ticks was compared by viral observations and time-lapse cine-micrography. the interaction of different rickettsial species with the haemocytes in vitro had specific characteristic features and reflected the pattern of interaction of the rickettsiae with tick cells in vivo. | 1980 | 6107037 |
| determination of immunoglobulin classes of antibodies against coxiella burnetii by protein a from staphylococcus aureus. | protein a from staphylococcus aureus was used for differentiating antibodies against coxiella burnetii according to immunoglobulin classes. interaction of immune serum with protein a resulted in complete (within the sensitivity limits of the methods used) removal of igg antibody and had practically no effect on the level of igm antibody. | 1980 | 6107038 |
| serological cross-reactions of lipid a components of lipopolysaccharides isolated from chlamydia psittaci and coxiella burnetii. | | 1980 | 6107040 |
| new antigens in coxiella burnetii? | | 1981 | 6115569 |
| suitability of the microagglutination test for detection of post-infection and post-vaccination q fever antibodies in human sera. | serological examination by the microagglutination (ma) and complement-fixation (cf) tests of human sera collected before and after vaccination with q fever chemovaccine revealed a higher sensitivity of the ma test for detecting both pre-vaccination antibodies reflecting a previous exposure to q fever and post-vaccination antibodies reflecting vaccine immunogenicity. in persons serologically positive before vaccination the level of post-vaccination ma antibody response was indirectly proportional ... | 1981 | 6116418 |
| effect of lysozyme on the immune response of guinea pigs to the soluble phase 1 antigen of coxiella burnetii. | | 1981 | 6116419 |
| stability of the adenosine 5'-triphosphate pool in coxiella burnetii: influence of ph and substrate. | the ability of coxiella burnetii to couple oxidation of metabolic substrates to adenosine 5'-triphosphate (atp) synthesis in axenic reaction buffers was examined. pyruvate, succinate, and glutamate were catabolized and incorporated at the highest rates of 11 substrates tested. glutamate oxidation, however, resulted in the greatest stability of the atp pool and highest intracellular atp levels over a 48-h period. at ph 4.5, the optimum for metabolism by c. burnetii, glutamate oxidation resulted i ... | 1981 | 6117546 |
| a rickettsia-like organism showing positive immunofluorescence with antisera to coxiella burnetii in haemaphysalis inermis ticks. | a rickettsia-like organism (rlo) was detected in the oocytes of haemaphysalis inermis ticks. the rlos were about 5 microns long bent rods with a definite inner structure. they were gram-negative and could be visualized by giemsa but not by gimenez staining. attempts to cultivate the rlo in chick embryo yolk sacs, various types of cell culture and tick body cavities were unsuccessful. the rlo displayed a bright immunofluorescence with antisera to coxiella burnetii, but no immunofluorescence was o ... | 1981 | 6118050 |
| laboratory outbreak of q fever acquired from sheep. | in april and may, 1981, an outbreak of q fever occurred in a university department which used gravid sheep for fetal respiratory studies. during the subsequent investigation 91 people were studied and 28 were found to have complement-fixing antibodies to the phase ii antigen of coxiella burneti in their serum. symptoms compatible with c. burneti infection occurred in 14 of the seropositive patients. the majority of symptomatic infections could be related to the delivery of twin fetuses in one la ... | 1982 | 6122819 |
| differential effects of cyclophosphamide on coxiella burnetii infection in mice. | treatment of mice with a single dose (200 mg/kg body weight) of cyclophosphamide (cpa) 3 days before intraperitoneal (i. p.) administration of coxiella burnetii did not substantially affect either the yield of c. burnetii from mouse spleen or the splenomegaly induced by the infection. administration of the same cpa dose 2 days after i. p. infection resulted in an increased yield of c. burnetii from the spleen and in a reduction of the spleen size as compared to cpa-untreated and cpa-pretreated i ... | 1982 | 6127018 |
| q-fever endocarditis in england and wales, 1975-81. | endocarditis was recorded in 92 (11%) of 839 confirmed q-fever infections reported for the communicable disease report by laboratories between 1975 and 1981; q-fever endocarditis accounted for approximately 3% of all cases of endocarditis reported. two-thirds of the 92 reports were of men, and in both men and women endocarditis affected mainly young and middle-aged adults. only one-third of q-fever endocarditis patients were noted to have an underlying heart-valve lesion. there were also 30 repo ... | 1982 | 6129519 |
| ph dependence of the coxiella burnetii glutamate transport system. | the transport of glutamate, apparently a primary energy source for coxiella burnetii, has been examined. c. burnetii is shown to possess a ph-dependent active transport system for l-glutamate with an apparent kt of 61.1 microm and vmax of 8.33 pmol/s per mg at ph 3.5. both l-glutamine and l-asparagine competitively inhibited transport of glutamate, but d-glutamate, l-aspartate, l-glutamate-gamma-methyl ester, methionine sulfoximine, or alpha-ketoglutarate did not compete. this transport system i ... | 1983 | 6132912 |
| induction of splenomegaly in mice by killed coxiella burnetii cells. | splenomegaly induced in mice inoculated intraperitoneally (i.p.) with purified formalin-killed phase i and phase ii coxiella burnetii (c.b.) cells was dose-dependent. the phase i cells induced higher splenomegaly than phase ii cells. the splenomegaly-inducing ability of phase i cells was reduced upon incubation with phase i but not with phase ii antiserum, whereas the phase ii cells preincubated with phase i or phase ii immune sera induced higher splenomegaly than the phase ii cells alone. phase ... | 1983 | 6133432 |
| comparison of the ultrastructure of small dense forms of chlamydiae and coxiella burnetii. | in the course of passaging of coxiella burnetii (c.b.) in alveonasus lahorensis ticks, the haemocytes contained cell forms with electrondense cytoplasm, intracytoplasmic lamellar membranes, and a peculiar limiting membrane--25 to 30 nm thick "envelope complex". similar small forms occurred when c.b. had been cultured in the yolk sack of chick embryos. the dense forms of c.b. were similar to those of rickettsiella cells. dense forms (elementary bodies) surrounded by an "envelope complex" were fou ... | 1983 | 6135336 |
| serologic survey for selected microbial pathogens in alaskan wildlife. | antibodies to brucella spp. were detected in sera of seven of 67 (10%) caribou (rangifer tarandus), one of 39 (3%) moose (alces alces), and six of 122 (5%) grizzly bears (ursus arctos). antibodies to leptospira spp. were found in sera of one of 61 (2%) caribou, one of 37 (3%) moose, six of 122 (5%) grizzly bears, and one of 28 (4%) black bears (ursus americanus). antibodies to contagious ecthyma virus were detected in sera of seven of 17 (41%) dall sheep (ovis dalli) and five of 53 (10%) caribou ... | 1983 | 6139490 |
| failure of q fever phase i corpuscular vaccine to influence the persistence and reactivation of coxiella burnetii infection in mouse and guinea pig tissues. | in mice and guinea pigs infected with coxiella burnetii, accumulation of large numbers of rickettsiae in the spleen and liver occurring at the early stages of infection was followed by clearing of these organs from the infectious agent but by its persistence in kidneys and reproductive tract at later intervals. the persistence of c. burnetii was not affected when one to six months-infected mice or guinea pigs were immunized with 100 or 500 micrograms of q fever phase i corpuscular vaccine. admin ... | 1983 | 6139946 |
| the value of skin test in q fever convalescents and vaccinees as indicator of antigen exposure and inducer of antibody recall. | the skin test (st) with q fever chemovaccine revealed more positive reactors than the serological examination by microagglutination (ma) test among humans, who had suffered from q fever one to eleven years ago or who had been vaccinated with q fever chemovaccine from three months to four years ago. when examining the sera harvested either at skin-testing or two weeks thereafter by ma test, seroconversion or rise in antibody titres were found to both main coxiella burnetii (c. b.) antigens. the r ... | 1984 | 6145346 |
| effect of coxiella burnetii on the stimulation of hexose monophosphate shunt and on superoxide anion production in human polymorphonuclear leukocytes. | killed coxiella burnetii (c.b.) cells in phase ii but not in phase i had a mild stimulatory effect on hexose monophosphate shunt (hmps) and superoxide anion production by human polymorphonuclear (pmn) leukocytes. preincubation of c.b. cells of either phase with serum of a leukocyte donor lacking detectable antibodies to c.b. did not affect the studied activities of pmn leukocytes. in contrast, both hmps stimulation and superoxide production were enhanced by specific opsonization of c.b. cells wi ... | 1984 | 6148002 |
| changing of antigenic, imumnogenic and chemical properties of a coxiella burnetii strain during chick embryo yolk sac passaging. | coxiella burnetii (c.b.) strain 48 after an increasing number of chick embryo yolk sac (ceys) passages had lost at egg passages (ep) 15--20 its antigenic, immunogenic and chemical properties typical of phase i. the change refers namely to phase i antibody-inducing ability in mouse, the inability to react in microagglutination (ma) test with the phase ii-specific serum, the loss of phase i antibody-binding capacity as detected by immunofluorescence (if), the capacity to induce an increased number ... | 1984 | 6148855 |
| sensitization of mice to rickettsial toxin by coxiella burnetii. | intraperitoneal (ip.) inoculation with live or killed coxiella burnetii (c.b.) rendered mice more sensitive to intravenous (iv.) administration of a toxic live suspension of rickettsia typhi. sensitization of mice by live and killed c.b. was time-and dose-dependent. killed phase i and phase ii c.b. cells possessed a similar degree of sensitization, which was increased slightly by their preincubation with corresponding immune sera. lipopolysaccharide (lps)-protein complex extracted from phase i c ... | 1984 | 6148856 |
| vaccine prophylaxis of abattoir-associated q fever. | q fever is an important cause of morbidity in australian meatworkers; recently there have been sharp outbreaks of q fever in abattoirs in several states. in an attempt to control q fever by vaccination, 924 nonimmune volunteers at two south australian abattoirs were inoculated with one dose of a purified, formalin-inactivated, coxiella burneti, henzerling strain, phase 1 vaccine. some 56% of workers in one abattoir, and 64% in the other, seroconverted after vaccination. in the 18 months after va ... | 1984 | 6151039 |
| q fever: antigens and vaccines. | | 1984 | 6151048 |
| household outbreak of q-fever pneumonia related to a parturient cat. | an outbreak of febrile respiratory disease occurred over 11 days among thirteen adults in nova scotia, all members of an extended family and their friends. signs of illness included bradycardia at the same time as fever, palatal petechiae, and rapidly enlarging bilateral pulmonary infiltrates. ten of the patients had a four-fold rise in antibody to phase-2 q-fever antigen as determined by complement fixation on acute and 4-week-convalescent serum samples. six children of the extended family for ... | 1984 | 6151054 |
| lipid a component of lipopolysaccharides from coxiella burnetii. | free lipid a from phase i and phase ii coxiella burnetii lipopolysaccharides was isolated and studied serologically. antisera against lipid a from phase i and phase ii c. burnetii cross-reacted with the lipid a preparations from both phases as well as with salmonella lipid a. | 1981 | 6169266 |
| temporal studies of factors associated with changes in transcription during q fever. | temporal studies were made of factors associated with increased rna synthesis in guinea pig liver during q fever. dna-dependent rna polymerase activities increased immediately after infection. the major distribution of rna polymerase classes shifted from class ii to class i during infection. ornithine decarboxylase activity was induced or stimulated soon after infection and remained elevated throughout the four-day period studied. s-adenosylmethionine decarboxylase activity increased on the firs ... | 1981 | 6172546 |
| protein synthesis by intact coxiella burnetii cells. | coxiella burnetii was isolated from persistently infected fibroblast host cells by a rapid mechanical lysis technique. macromolecular synthesis was initiated in these otherwise dormant cells by incubation at ph 4.5. the synthesis of protein proceeded for as long as 24 h. initiation of protein synthesis in c. burnetii was dependent upon rna synthesis. approximately 24 species of polypeptides were synthesized, and some of these appeared to be major synthetic products. increases in protein biomass ... | 1983 | 6194147 |
| experimental studies on the virus of "q" fever. | the virus isolated by derrick from cases of fever produces characteristic pathogenic effects on monkeys and mice. a well-defined febrile reaction, during which the blood is infective for guinea-pigs, follows subcutaneous inoculation of virus in the monkey. mice inoculated intraperitoneally show enlargement of spleen and liver with characteristic histological changes. in sections and smears of infected mouse liver and spleen large numbers of rickettsial organisms are visible. these occur in relat ... | 1983 | 6194551 |
| studies of the antigenic structure of coxiella burnetii. | the antigenic structure of coxiella burnetii (c.b.) was studied by absorption of human and animal immune sera with c.b. organisms in the natural phase ii (nph ii) or with artificial phase ii (arph ii) organisms prepared by their treatment with kio4. it was found that immune sera absorbed with one type of phase ii organisms still reacted with the antigen of another type of phase ii organisms as demonstrated in both microagglutination (ma) and complement-fixation (cf) tests. | 1983 | 6195899 |
| phagocytosis of coxiella burnetii by hyalomma dromedarii tick haemocytes. | haemocytes of laboratory bred half-engorged hyalomma dromedarii ticks phagocytized intracoelomally inoculated coxiella burnetii organisms. significantly higher phagocytosis of phase ii than phase i c. burnetii was observed, irrespective of whether live, killed untreated or killed organisms treated with chloroform-methanol (cm) mixture were used. however, hcl- or kio4-treated phase i cells were phagocytized to a similar extent as phase ii cells. more consistent results were obtained with haemocyt ... | 1984 | 6201060 |
| [q-fever in a rehabilitation center for drug addicts]. | | 1982 | 6213895 |
| [outbreak of q fever among persons not occupationally connected with the source of the infection]. | | 1983 | 6230774 |
| in vitro studies of interaction of rickettsia and macrophages: effect of ultraviolet light on coxiella burnetii inactivation and macrophage enzymes. | the inactivation of coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (uv) light was studied. the effect of uv treatment on the activity of macrophage organelle marker enzymes and their subsequent equilibration in linear sucrose gradients was also determined. it was shown that uv treatment of 600 mu w/cm2 for 15 s at a distance of 10 cm inactivated c. burnetti, either in suspension (10(8) organisms per ml) or within guinea pig peritoneal macrophag ... | 1980 | 6247280 |
| causes of atypical pneumonia: results of a 1-year prospective study. | in a protocol study of cases of atypical pneumonia over a 1-year period an etiologic agent was established in 16 cases: legionella pneumophila in 8, coxiella burnetii in 3, chlamydia trachomatis in 2, mycoplasma pneumoniae in 1, para-influenza 3 virus in 1 and cytomegalovirus in 1. in the remaining 11 cases no agent was identified; the illnesses in these cases tended to be less severe. the pneumonia took much longer to resolve in the patients with legionnaires' disease than in all the other pati ... | 1981 | 6275975 |
| different sugar compositions of lipopolysaccharides isolated from phase i and pure phase ii cells of coxiella burnetii. | the compositions of lipopolysaccharides i and ii, isolated from coxiella burnetii phase i and pure phase ii cells, respectively, showed drastic and clear-cut differences. lipopolysaccharide ii exhibited a comparatively simple composition. it contained, in addition to glucosamine (from lipid a) and a 2-keto-3-deoxyoctulosonic acid-related, thiobarbituric acid-positive substance, only two aldoses in high amounts, namely d-mannose and d-glycero-d-mannoheptose. lipopolysaccharide i contained the sam ... | 1982 | 6292100 |
| superoxide anion production and superoxide dismutase and catalase activities in coxiella burnetii. | coxiella burnetii was examined for superoxide anion (o2-) production and superoxide dismutase and catalase activities. the organism generated o2- at ph 4.5 but not at ph 7.4. the rickettsia displayed superoxide dismutase activity distinguishable from that of the host cell (l-929 mouse fibroblast). catalase activity was maximal at ph 7.0 and diminished at ph 4.5. these enzymes may account, in part, for the ability of this obligate intracellular parasite to survive within phagocytes. | 1983 | 6300038 |
| estimation of the cytoplasmic ph of coxiella burnetii and effect of substrate oxidation on proton motive force. | the magnitude of the proton motive force generated during in vitro substrate oxidation by coxiella burnetii was examined. the intracellular ph of c. burnetii varied from about 5.1 to 6.95 in resting cells over an extracellular ph range of 2 to 7. similarly, delta psi varied from about 15 mv to -58 mv over approximately the same range of extracellular ph. both components of the proton motive force increased during substrate oxidation, resulting in an increase in proton motive force from about -92 ... | 1983 | 6302078 |
| [histopathologic, ultrastructural, immunologic and virologic study of gibert's pityriasis rosea]. | a complete study of pityriasis rosea (gibert) has been performed; this study includes: --a pathological and ultrastructural examination of the skin biopsies; --an immunological study: direct and indirect immunofluorescence (seric anti-cutaneous antibodies); --a virological investigation: ultrastructural examination of the specimens, inoculation of homogenized-skin specimens to 3 cellular cultures; --serological investigations for influenza a, b, parainfluenza 1, 2, 3, adenovirus, respiratory syn ... | 1982 | 6303189 |
| isolation and characterization of a plasmid from phase i coxiella burnetii. | the dna from the nine mile phase i strain of coxiella burnetti, the etiological agent of q fever, has been isolated and purified by cesium chloride-ethidium bromide density gradient centrifugation. a fraction of this dna has a density characteristic of plasmid dna. the plasmid dna was cut with 20 different restriction endonucleases and shown to be a discrete entity. the plasmid, designated qph1, is approximately 36 kilobases in size and has a molecular mass of 2.4 x 10(7) daltons. a partial rest ... | 1983 | 6307871 |
| serologic survey of california wild hogs for antibodies against selected zoonotic disease agents. | blood samples were collected from trapped or hunter-killed wild hogs (sus scrofa) in 4 areas of california. sera were tested for antibodies against 7 zoonotic disease agents. antibodies against brucella sp were detected in 21 (15%) of 136 samples. antibodies against coxiella burnetii were found in 50% of the collected samples (67 of 135 tested). of the 135 wild hogs screened for pseudorabies virus, 4 (3%) were seropositive. leptospira interrogans antibodies were discovered in 118 (87%) of the 13 ... | 1983 | 6315659 |
| phosphorylation-dephosphorylation of nuclear proteins during infection (q fever). | the proposal that gene expression may be regulated by phosphorylation of nonhistone chromatin proteins was tested by studying increased transcription resulting from q fever. certain liver nuclear phosphoprotein kinase and phosphatase activities were altered after guinea pigs were infected with coxiella burnetii. nonhistone chromatin proteins had increased phosphoprotein kinase activity and were differentially phosphorylated. the addition of spermine equally stimulated nuclear phosphoprotein kina ... | 1984 | 6317563 |
| [serodiagnosis of human q-fever--demonstration of non-complement binding igm antibodies in the enzyme-linked immunosorbent assay (elisa)]. | the application of an indirect elisa for detection of igm and igg antibodies against coxiella burnetii in five q fever patients--among them one with endocarditis and one with hepatitis--is described. in the acute phase of infection, within a few days after onset of clinical symptoms, a significant rise of igm antibodies could be detected. it was followed by a rise of igg in the second and third week. in chronic q fever endocarditis, igm antibodies persisted over a period of nine months. high igm ... | 1984 | 6334014 |
| immunoglobulin responses to coxiella burnetii (q fever): single-serum diagnosis of acute infection, using an immunofluorescence technique. | blood specimens were collected over various periods of time from 30 abattoir workers with a clinical diagnosis of q fever. all specimens were tested for complement-fixing antibodies and for specific immunoglobulin m (igm) globulins to phase 1 and 2 coxiella burnetii organisms by an immunofluorescence technique. all 22 patients with increasing levels of complement-fixing antibodies were shown to have generated specific igm globulins, as did 4 patients with high convalescent titers but from whom " ... | 1983 | 6339396 |
| q fever and coxiella burnetii: a model for host-parasite interactions. | | 1983 | 6348504 |
| initial clinical and immunologic evaluation of a new phase i q fever vaccine and skin test in humans. | a new phase i q fever skin test was administered to 74 subjects. thirty-eight had less than 8 mm and 36 had greater than or equal to 10 mm erythema at 24 hr. only 14 had circulating antibody. three skin test-positive and 17 skin test-negative, seronegative individuals subsequently received 6 or 30 micrograms of vaccine in a single dose. all skin test-positive individuals and one skin test-negative individual developed mild local reactions. seventeen of 18 recipients developed fluorescent antibod ... | 1983 | 6350491 |
| detection and persistence of specific igm antibody to coxiella burnetii by enzyme-linked immunosorbent assay: a comparison with immunofluorescence and complement fixation tests. | an enzyme-linked immunosorbent assay (elisa) for specific igm antibody to coxiella burnetii was compared with the indirect immunofluorescence (fa) test in studies of 130 serum samples from 38 patients with q fever. the igm fractions obtained after rate zonal-density gradient ultracentrifugation of 37 serum samples from 12 patients were also studied in a complement fixation test (cf-dg). specific igm antibody to c burnetii was detected by all three methods in sera collected two to eight weeks aft ... | 1983 | 6352826 |
| experimental study of enzyme-linked immunosorbent assay (elisa) for detection of q fever antibody. | | 1983 | 6353304 |
| [q fever in the ukraine]. | q fever occurs in all geographical landscape zones and in most administrative regions of the ukrainian ssr. the disease was diagnosed in those areas where no such cases had ever been registered. in the kharkov region the examination of 425 fever patients with unclear diagnosis resulted in diagnosing 5 cases of q fever. the proportion of seropositive persons among different professional groups of the population in the eastern part of the republic was determined (6.9% among workers of meat-packing ... | 1983 | 6353813 |
| [comparative value of complement fixation and indirect immunofluorescence reactions for the detection of q fever]. | 1 052 serum samples from 1 013 persons living in rural areas, were tested by if and cf; with the if-test, 4% of them were sero-positive (titer greater than or equal to: 20). if-tests are eightfold more sensitive than cf tests and have at least the same specificity. the results of two (commercial) coxiella burnetii phase ii antigens were compared. | 1984 | 6366707 |
| [coexistence of legionnaires' disease and q fever in a single patient]. | a case of legionnaires' disease associated with q fever is presented; this is probably the first reported case of concomitant infections with legionella pneumophila and coxiella burnetii. the pulmonary features of the illness were not typical of either disease. the difficulties of making a diagnosis in such cases are discussed. | 1984 | 6367919 |
| [comparative studies of guinea pig and mouse tests for the detection of coxiella burnetii--and a study of q fever distribution in south and central hessen]. | | 1984 | 6368176 |
| [prevalence of q fever in indigenous cattle]. | | 1984 | 6368177 |
| rapid detection by immunofluorescence of multiple viral infections in patients with keratitis. | the presence of 12 viral (herpes 1 and 2, influenza a(h1n1), a(h3n2) and b, parainfluenza 1, 2, 3, adenovirus 5) and inframicrobial (chlamydia, mycoplasma, rickettsia burneti) antigens was investigated by direct or indirect immunofluorescence (if) reactions in exfoliated conjunctival cells from 110 patients with nonbacterial keratitis and keratoconjunctivitis. a rapid etiological diagnosis could be obtained in 101 (92%) of the cases, parainfluenza and herpes antigens being the most frequently de ... | 1984 | 6377681 |
| a rapid immunofluorescent procedure for serodiagnosis of q fever in mice, guinea pigs, sheep, and humans. | the ability to diagnose q fever has been hampered by the fact that diagnosis depends upon difficult serologic tests such as complement fixation (cf) or slide immunofluorescence performed only at reference laboratories. a new quantitative solid phase fluorescent antibody test (fiax) has recently been developed and applied to measure antibodies in several microbial systems. the test takes less than 2 hr to perform and employs stable reagents. we have utilized this technique and developed a rapid i ... | 1983 | 6388964 |
| [q fever in the netherlands; a description of 33 case reports observed between 1979 and 1983]. | | 1984 | 6392902 |
| early diagnosis of q fever: detection of immunoglobulin m by radioimmunoassay and enzyme immunoassay. | the use of a radioimmunoassay and an enzyme immunoassay for early diagnosis of q fever is described, both of which are based on the igm antibody-capture principle. a commercially available phase ii antigen and a labeled, purified anti-q-igg of human origin were employed. with these tests q fever antibodies were detected earlier in the course of infection than with the complement fixation test. | 1984 | 6396092 |
| [current data on rickettsial diseases in tunisia]. | the indirect immunofluorescent technic, recommended by who, allows us to consider again, the problem of rickettsial diseases in tunisia. this pathology, always actual, presents, also in epidemiological as in clinical aspect, a predominance for mediterranean spotted fever by r. conori. murin typhus by r. mooseri is still remained, but its incidence seems to be slight. the frequency of q fever must to be determined. | 1984 | 6399973 |
| [q fever in cows with special reference to coxiella burnetii colonization of the udder]. | | 1984 | 6400460 |
| different antigenic properties of lipopolysaccharides isolated from coxiella burnetii in phase i and pure phase ii. | lipopolysaccharides (lpss) isolated from coxiella burnetii cells in phase i and pure phase ii behaved as antigens reacting in serological tests (passive haemolysis, passive haemolysis inhibition, complement-fixation, immunoprecipitation) with sera of rabbits immunized with c. burnetii strains in the corresponding phase. no cross-reactions were observed between lpss isolated from c. burnetii in phase i and phase ii, respectively. | 1983 | 6417946 |
| rickettsial antibody prevalence in southern israel: igg antibodies to coxiella burnetii, rickettsia typhi, and spotted fever group rickettsiae among urban- and rural-dwelling and bedouin women. | a retrospective serological survey was carried out using sera obtained from women at childbirth in the southern desert region of israel to determine exposure experience to three rickettsial agents: coxiella burnetii, rickettsia typhi, and spotted fever group rickettsiae. using the indirect fluorescent antibody method for determining igg antibodies, it was found that about 40% of all sera examined demonstrated antibodies to one or more rickettsiae. bedouin women appeared to be at greater risk of ... | 1983 | 6418016 |
| monoclonal antibodies distinguish phase variants of coxiella burnetii. | monoclonal antibodies (mabs) directed against phase i and ii variants of coxiella burnetii were produced by fusing myeloma sp2/o-ag 14 cells with spleen cells from mice immunized with the chloroform-methanol extraction residue of phase i whole cells. two hybridoma clones which distinguished the phase variants by microimmunofluorescence assay were isolated and characterized. the mabs showing specificity for phase i cells (mabi-1, immunoglobulin g, subclass 3 kappa) reacted with the hot phenol-wat ... | 1984 | 6418662 |
| importance of viruses and legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis. | from january to april 1980 46 young adults with cystic fibrosis were studied for evidence of infection with a wide variety of microorganisms, including viruses and legionella pneumophila. two groups of patients were investigated: a "deteriorated" group of 24 patients who had experienced an increase in lower respiratory tract symptoms and fall in lung function values in the course of one month before the start of the study and a "stable" group of 22 patients with no such deterioration. all serolo ... | 1984 | 6422578 |
| q fever outbreak--switzerland. | | 1984 | 6427585 |
| interferon-gamma inhibits growth of coxiella burnetii in mouse fibroblasts. | we studied the effects of various mouse interferon preparations on the growth of coxiella burnetii in mouse fibroblasts. the addition of both recombinant interferon-gamma and a crude lymphokine preparation that contained interferon-gamma to infected l929 cells inhibited the growth of c. burnetii, whereas the addition of a crude preparation of type i interferons did not. cycloheximide suppressed the inhibitory effects of recombinant interferon-gamma and crude lymphokines. | 1984 | 6432701 |
| [serological study of the presence of antibodies against coxiella burnetti and brucella abortus in veterinarians in the netherlands]. | two hundred and twenty-two large animal practitioners in the netherlands were studied serologically for the presence of antibodies to coxiella burnetii (q-fever) and brucella abortus. eighty-four percent showed antibodies to coxiella burnetii, which were equally distributed over all age-groups. for blood donors the proportion in men was 31 per cent and 14 per cent in women, also equally distributed over all age-groups. in the case of brucella abortus, the number of veterinarians showing antibodi ... | 1984 | 6435281 |
| chemical and immunological characterization of lipopolysaccharides from phase i and phase ii coxiella burnetii. | lipopolysaccharides (lpss) isolated from phase i and phase ii coxiella burnetii (lps i and lps ii, respectively) were analyzed for chemical compositions, molecular heterogeneity by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and immunological properties. the yields of crude phenol-water extracts from phase i cells were roughly three to six times higher than those from phase ii cells. purification of lpss by ultracentrifugation gave similar yields for both lps i and lps ii. purifie ... | 1984 | 6438066 |
| [study of the relationship between rickettsia burneti and ixodoidea ticks]. | | 1980 | 6446664 |
| epidemiological studies of q fever in the area of dzhambul in the kazakh ssr. | the frequency of q fever in the area of dzhabmul varies from 1.0 [district of kurdayi, 1968] to 18.1 [district of talass, 1972] for 100,000 inhabitants. the lower incidence of q fever in the rural population, compared to that of inhabitants of towns, is closely associated with the development of early immunity. farm animals are the main source of infection. the persistent circulation of rickettsia burneti among wild life is maintained by wild mammallans and ticks ixodes. | 1980 | 6447720 |
| [vaccination against q fever in occupationally exposed persons in the district velký kritís (author's transl)]. | | 1981 | 6451301 |
| computed tomographic brain scan findings in q fever encephalitis. | neurological involvement in q fever is unusual. we present a case of encephalitis due to coxiella burnetii with neuroradiologic findings on ct not described previously, consisting in areas of decreased absorption coefficient in the subcortical white matter of both hemispheres, predominantly in the right. differential diagnosis must be established from viral encephalitis, of similar clinical presentation, which may show similar ct lesions to those in this case. | 1984 | 6462442 |
| unsuspected q fever endocarditis--a case report. | | 1984 | 6464235 |
| induction of hyperreactivity to endotoxin in mice by coxiella burnetii. | intraperitoneal inoculation of mice with live or killed coxiella burnetii phase i or phase ii cells induced a marked hyperreactivity to the lethal effect of bacterial endotoxin and was accompanied by a marked hepatosplenomegaly. the degree and duration of hyperreactivity depended on the dose of c. burnetii administered and were higher with phase i than with phase ii cells. sensitization to the lethal effects of endotoxin and induction of splenomegaly by phase i c. burnetii cells also proceeded i ... | 1984 | 6469358 |
| [early-onset endocarditis on a heart valve prosthesis caused by coxiella burnetii]. | | 1984 | 6473877 |
| tick-borne rickettsioses in pune district, maharashtra, india. | an extensive study on tick-borne rickettsioses in the pune district of maharashtra revealed that indian tick typhus exists as a zoonosis, which only occasionally causes disease in man. by sero-conversion in guinea pigs, presumptive isolates of rickettsia conori and coxiella burnetii were recovered from 4 of the 11 species of ticks examined. boophilus microplus and rhipicephalus haemaphysalis were found to be harbouring r. conori whereas c. burnetii was isolated from haemaphysalis intermedia and ... | 1984 | 6500861 |
| biochemical and immunological properties of coxiella burnetii cell wall and peptidoglycan-protein complex fractions. | coxiella burnetii morphological cell types were fractionated into large-cell variant cell walls, two fractions of small-cell variant cell walls, and one fraction of small-cell variant whole cells. based on the contents of peptidoglycan (pg)-constituents and the yields of the sodium dodecyl sulfate-insoluble pg-protein complex (pg-pc) from cell walls, the fraction of large-cell variant cell walls contained significantly less pg than did the fraction of small-cell variant cell walls. the yields of ... | 1984 | 6501233 |
| sensitivity of coxiella burnetii peptidoglycan to lysozyme hydrolysis and correlation of sacculus rigidity with peptidoglycan-associated proteins. | the protease-resistant proteins associated with the peptidoglycan (pg) of the phase i small-cell variant coxiella burnetii were either partially released from the pg by boiling the pg-protein complex (pg-pc) in sodium dodecyl sulfate containing 2-mercaptoethanol and edta or totally released by 1 n naoh hydrolysis at 23 degrees c. an 18,300-dalton protein was released from the pg-pc under reducing conditions, whereas 1 n naoh treatment extracted pg-associated proteins without apparent dissolution ... | 1984 | 6501234 |
| the radiographic features of epidemic and sporadic q fever pneumonia. | radiographic dissimilarities exist between the chest radiographs of patients with epidemic and sporadically-occurring q fever pneumonia. chest radiographs of 25 patients with q fever pneumonia were retrospectively assessed, and demonstrated previously unreported differences between these two broad groups. differing strains of coxiella burnetii, or varying doses of the pathogen, are postulated as the pathogenetic mechanisms for the observed discrepant findings. | 1984 | 6501384 |
| [q fever infection probably caused by a human placenta]. | | 1984 | 6514045 |
| [epidemiology of q fever in hesse: studies using enzyme immunoassay and the complement fixation reaction]. | | 1984 | 6525159 |
| [pulmonitis caused by coxiella burneti and chlamydia psittaci. 2 years of research in marche]. | this paper point to infections caused by chlamydia psittaci and coxiella burneti in a region of the middle italy (marche) from april 1981 to march 1983. 32 of 686 cases (about 5%) of pneumonia were diagnosed as q fever or ornithosis-psittacosis. the role of the research of these etiologies in routine diagnostic work on acute respiratory infections is underlined. | 1984 | 6534399 |
| coxiella burnetii antibodies in some nigerian dairy cows and their suckling calves. | dairy cows and their suckling calves kept at institutional and governmental farms under semi-intensive husbandry and dual purpose fulani nomadic herds with extensive management system around zaria, nigeria were screened for antibodies against coxiella burnetii using the capillary agglutination test (cat). an antibody prevalence of 59.8% detected among 306 dairy cows under both management systems was significantly (p less than 0.01, x2) higher than was found among their suckling calves where 41.0 ... | 1984 | 6534901 |