| an immunohistochemical and polymerase chain reaction evaluation of feline plasmacytic pododermatitis. | sections of 14 skin biopsies of cats with plasmacytic pododermatitis and a clinical follow-up of 12-36 months were stained with a polyclonal anti-mycobacterium bovis (bacille calmette-guerin = bcg) antibody cross-reactive to a broad spectrum of fungi and bacteria. all sections were negative for organisms within the actual footpad tissue with the anti-bcg antibody stains. polymerase chain reaction (pcr) assays that amplify the dna of bartonella spp., ehrlichia spp., anaplasma phagocytophilum, chl ... | 2007 | 17197627 |
| [serous macular detachment as an atypical sign in cat scratch disease]. | case report: a 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. this diagnosis was made by serum antibody titers and the clinical course. discussion: although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina. | 2006 | 17199167 |
| [phlebotomine sandflies and transmission of disease agents around the mediterranean basin]. | around 800 species of phlebotomine sandflies are widely distributed in tropical and temperate areas. some sand flies are documented vectors of human disease agents including parasitic protozoa, (leishmania spp), bacteria (bartonella bacilliformis) and viruses (phlebovirus). in addition to presenting morphologic, taxonomic and biologic aspects of phlebotomine sandflies, this report focuses on ecologic, epidemiologic, ethologic, and anthropic factors contributing to the proliferation of sand flies ... | 2006 | 17201284 |
| the low seroprevalence of tick-transmitted agents of disease in dogs from southern ontario and quebec. | infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout north america. the purpose of this study was to determine the seroprevalence of selected vector-transmitted pathogens in southern ontario and quebec. samples submitted to the vector borne disease diagnostic laboratory (vbddl) at the north carolina state university college of veterinary medicine were evaluated for antibodies to ... | 2006 | 17217089 |
| [rash and purulent lymphadenitis in cat scratch disease]. | we present a case of a cat-scratch disease (csd) presenting with typical (primary lesion and regional lymphadenitis) and rare (purulent lymphadenitis and maculopapular rash) symptoms and positive epidemiological data. laboratory blood test showed normal values for routine parameters, except for mild leukocytosis (l 12.4 x 10(9)), elevated erythrocyte sedimentation rate (se 65/h) and moderately elevated asparta e-aminotransferase and alanine-aminotransferase values (ast/alt 48/90), fibrinogen (5. ... | 2006 | 17217106 |
| a survey of zoonotic pathogens carried by norway rats in baltimore, maryland, usa. | norway rats (rattus norvegicus) carry several zoonotic pathogens and because rats and humans live in close proximity in urban environments, there exists potential for transmission. to identify zoonotic agents carried by rats in baltimore, maryland, usa, we live-trapped 201 rats during 2005-2006 and screened them for a panel of viruses, bacteria, and parasites. antibodies against seoul virus (57.7%), hepatitis e virus (hev, 73.5%), leptospira interrogans (65.3%), bartonella elizabethae (34.1%), a ... | 2007 | 17224086 |
| rickettsial pathogens in the tropical rat mite ornithonyssus bacoti (acari: macronyssidae) from egyptian rats (rattus spp.). | we collected and tested 616 tropical rat mites (ornithonyssus bacoti (hirst)) from rats (rattus norvegicus (berkenhout) and r. rattus (linnaeus)) throughout 14 governorates in egypt and tested dna extracts from pools of these mites for bartonella spp., coxiella burnetii, and rickettsia spp. by pcr amplification and sequencing. three different mite-associated bacterial agents, including one bartonella and two rickettsia spp., were detected in eight pools of mites. further research could demonstra ... | 2007 | 17225079 |
| cat-scratch disease relapse in a kidney transplant recipient. | cat-scratch disease, an infectious illness infrequently reported in kidney transplant patients, is caused by the organism bartonella henselae and is transmitted through contact with cats or kittens. it is a self-limited disorder in the general pediatric population. here we present a case of unsuspected cat-scratch disease in a pediatric kidney transplant patient who presented with fever and lymphadenopathy. eight months after treatment with a short course of azithromycin, the patient developed a ... | 2007 | 17239132 |
| cat scratch disease causing hepatic masses after liver transplant. | hepatic cat scratch disease is rarely reported in liver transplant recipients and has never been reported with discrete liver lesions in the graft. a 52-year-old woman was transplanted for hepatitis c cirrhosis and hepatocellular carcinoma. her posttransplant course was uneventful. she presented 2.7 years after transplantation with fever of unknown origin and went on to develop multiple and diffuse discrete liver lesions. despite an extensive work-up including percutaneous and laparoscopic biops ... | 2007 | 17241393 |
| serologic survey of eptesicus fuscus from georgia, u.s.a. for rickettsia and borrelia and laboratory transmission of a rickettsia by bat ticks. | bats and their ectoparasites are associated with bacterial agents of unknown pathogenicity. we tested sera from 56 eptesicus fuscus from georgia against borrelia hermsii, orientia tsutsugamushi, rickettsia conorii, and rickettsia rickettsii. we detected antibodies reactive against a relapsing fever borrelia and spotted fever group rickettsia in 3/56 and 1/56 bats, respectively. we attempted to culture bartonella from the blood of these bats but were unsuccessful. in addition, we fed bat ticks, c ... | 2006 | 17249357 |
| bartonella infections in fleas (siphonaptera: pulicidae) and lack of bartonellae in ticks (acari: ixodidae) from hungary. | fleas (95 pulex irritans, 50 ctenocephalides felis, 45 ctenocephalides canis) and ixodid ticks (223 ixodes ricinus, 231 dermacentor reticulatus, 204 haemaphysalis concinna) were collected in hungary and tested, in assays based on pcr, for bartonella infection. low percentages of p. irritans (4.2%) and c. felis (4.0%) were found to be infected. the groel sequences of the four isolates from p. irritans were different from all the homologous sequences for bartonellae previously stored in genbank bu ... | 2006 | 17252927 |
| bartonella henselae infection in splenectomized domestic cats previously infected with hemotropic mycoplasma species. | cat scratch disease is caused by bartonella henselae and the domestic cat represents its main reservoir. in immunocompromised patients, infection with b. henselae is characterized by more severe clinical forms than in non-immunocompromised individuals. the objective of the present study was to investigate the characteristics of b. henselae (houston-i strain) infection in four splenectomized and three non-splenectomized cats, five of which were chronically infected with 'candidatus mycoplasma hae ... | 2007 | 17254639 |
| demographic features of bartonella infections in richardson's ground squirrels (spermophilus richardsonii). | the epidemiology of bartonella infections in richardson's ground squirrels (spermophilus richardsonii) was studied at multiple sites in saskatchewan, canada, from 2002 to 2004. the overall prevalence of bartonella infection was 48%. juvenile squirrels were significantly more likely to be infected with bartonella than were adults (58% and 37%, respectively), and juvenile animals also were significantly more likely to have high levels of bacteremia compared to adult animals. prevalence of bartonel ... | 2006 | 17255440 |
| effect of experimental ectoparasite control on bartonella infections in wild richardson's ground squirrels. | the purpose of this study was to investigate the role of ectoparasites in transmitting bartonella infections in wild richardson's ground squirrels (spermophilus richardsonii). richardson's ground squirrels were trapped, examined for fleas, and tested for bartonella bacteremia once monthly, at six sites, from april to september 2004. after the initial trapping session in april, burrows at three sites were treated with deltamethrin insecticide. richardson's ground squirrels trapped on treated site ... | 2006 | 17255441 |
| high suspicion of bacillary angiomatosis in a kidney transplant recipient: a difficult way to diagnose--case report. | bacillary angiomatosis is an infection caused by bartonella, which has first been described in human immunodeficiency virus (hiv)-infected patients. we report an unusually located lesion, in a totally asymptomatic kidney transplant recipient. the diagnosis was strongly suggested based on the iconography and our histological analysis, but was not confirmed using polymerase chain reaction (pcr) and immunohistochemical studies. we illustrate our difficult way to the diagnosis as well as the course ... | 2007 | 17275532 |
| haemoparasites of common shrews (sorex araneus) in northwest england. | the presence of haemoparasites belonging to the taxa anaplasma, bartonella and trypanosoma was determined among 76 common shrews (sorex araneus) from northwest england. anaplasma phagocytophilum dna was recovered from the blood of 1 shrew (1.3%), with the amplified 16s rrna sequence identical to one previously reported from a bank vole (clethrionomys glareolus). trypanosoma spp. dna was detected in 9 shrews (11.8%), the amplified 18s rdna fragments being indistinguishable from one another, and d ... | 2007 | 17288633 |
| [infections dues to bartonella spp.]. | the genus bartonella now includes four species which may infect humans : b. bacilliformis, b. quintana, b. henselae, and b. elizabethae. b. bacilliformis, the agent of carrion's disease, was the only species of the genus since 1993 when rochalimaea species were removed from the genus rochalimaea and included in the genus bartonella, within the family bartonellaceae. b. quintana is the etiologic agent of trench fever, bacillary angiomatosis, septicemia, endocarditis, and chronic lymphadenopathy. ... | 1996 | 17292303 |
| detection of rickettsia rickettsii and bartonella henselae in rhipicephalus sanguineus ticks from california. | sixty-two questing adult rhipicephalus sanguineus (latreille) ticks were collected by direct removal from blades of turfgrass and adjacent concrete walkways at a suburban home in riverside county, ca, and tested for the presence of rickettsia, bartonella, and ehrlichia dna. polymerase chain reaction (pcr) was used to amplify fragments of the 17-kda antigen gene and the rompa gene of the spotted fever group rickettsiae. one male tick contained r. rickettsii dna; its genotype differed from r. rick ... | 2007 | 17294935 |
| an hiv-positive patient with cervical lymphadenopathy and skin lesions. | | 2007 | 17304465 |
| proteomic and immunoblot analyses of bartonella quintana total membrane proteins identify antigens recognized by sera from infected patients. | bartonella quintana is a fastidious, gram-negative, rod-shaped bacterium that causes prolonged bacteremia in immunocompetent humans and severe infections in immunocompromised individuals. we sought to define the outer membrane subproteome of b. quintana in order to obtain insight into the biology and pathogenesis of this emerging pathogen and to identify the predominant b. quintana antigens targeted by the human immune system during infection. we isolated the total membrane proteins of b. quinta ... | 2007 | 17307937 |
| living without fur: the subtlety and complexity of iron-responsive gene regulation in the symbiotic bacterium rhizobium and other alpha-proteobacteria. | the alpha-proteobacteria include several important genera, including the symbiotic n(2)-fixing "rhizobia", the plant pathogen agrobacterium, the mammalian pathogens brucella, bartonella as well as many others that are of environmental or other interest--including rhodobacter, caulobacter and the hugely abundant marine genus pelagibacter. only a few species--mainly different members of the rhizobia--have been analyzed directly for their ability to use and to respond to iron. these studies, howeve ... | 2007 | 17310401 |
| adult systemic cat scratch disease associated with therapy for hepatitis c. | we describe the first case of systemic cat scratch disease in a patient receiving peginterferon alpha-2a and ribavirin for treatment of hepatitis c. cases of adult systemic csd are extremely infrequent and immunomodulatory treatment for hepatitis c has been associated with aberrant host responses to common pathogens. | 2007 | 17319959 |
| experimental infection of domestic cats with passaged genotype i bartonella henselae. | the influence of in vitro passage on bartonella henselae pathogenesis in cats has not been thoroughly evaluated. our objective was to examine the bacterial kinetics and humoral immune responses in cats experimentally infected with three different in vitro passages of b. henselae f1, a genotype i strain of feline origin. the f1 strain was in vitro passaged 20 and 40 times, and each was inoculated into a group of 5 cats. the kinetics of bacteremia and the feline humoral immune response to bacteria ... | 2007 | 17321078 |
| bartonella quintana endocarditis in dogs. | we provide the first evidence that bartonella quintana can infect dogs and cause typical signs of endocarditis. using pcr and sequencing, we identified b. quintana in the blood of a dog from the united states with aortic valve endocarditis and probably also in the mitral valve of a dog from new zealand with endocarditis. | 2006 | 17326937 |
| detection of bartonella henselae dna in two dogs with pyogranulomatous lymphadenitis. | 1 dog evaluated because of inappetence and lameness of the left hind limb of 1 day's duration and 1 dog evaluated because of inappetence, fever, and lymphadenopathy of 2 weeks' duration. | 2007 | 17331050 |
| recurrent expressive aphasia as a presentation of cat-scratch encephalopathy. | cat-scratch disease is a common disease, occurring in an estimated 24,000 patients annually in the united states, and is one of the most common causes of chronic lymphadenitis in children. a wide array of neurologic complications occurs as a result of cat-scratch disease. however, there have been no reports of acute-onset, self-resolving, recurrent, expressive aphasia, as we report here in an adolescent boy. in our case, establishing the diagnosis of cat-scratch encephalopathy saved time and res ... | 2007 | 17332191 |
| cat scratch disease during etanercept therapy. | lymphadenopathy in a patient taking tnfalpha antagonist therapy may indicate lymph node tuberculosis or a hematological malignancy. although histological evidence of granuloma suggests tuberculosis, many other infections responsible for granulomatous reactions have been reported in patients on tnfalpha antagonist therapy. we report a case of granulomatous lymphadenopathy due to bartonella henselae in a patient taking etanercept to treat ankylosing spondylitis. | 2007 | 17337229 |
| cat scratch disease with epidural extension while on antimicrobial treatment. | we report the first case of a child with an epidural abscess caused by bartonella henselae. this case is unique in that the diagnosis was confirmed by polymerase chain reaction (pcr) of the abscess fluid. a 3-year-old male was admitted with a 1-week history of fever and lower back pain. magnetic resonance imaging (mri) of the lumbar spine revealed a paraspinal soft tissue abnormality extending from the t(12) to the l(4) level, and a computed tomography (ct) scan of the lumbar spine showed osteom ... | 2007 | 17337934 |
| bartonella henselae lymphadenitis progressing to hepatosplenic disease with slow clinical response despite early diagnosis and treatment. | | 2008 | 17343673 |
| a combined approach for the enhanced detection and isolation of bartonella species in dog blood samples: pre-enrichment liquid culture followed by pcr and subculture onto agar plates. | historically, direct plating, lysis centrifugation, or freeze-thaw approaches have proven to be highly insensitive methods for confirming bartonella species infection in dogs. a prospective study was designed to compare diagnostic methods for the detection of bartonella using samples submitted to the vector-borne disease diagnostic laboratory at north carolina state university. methods included indirect immunofluorescence assay, pcr, direct inoculation of a blood agar plate (trypticase soy agar ... | 2007 | 17346836 |
| encephalitis lethargica following bartonella henselae infection. | | 2007 | 17351727 |
| [molecular genetic methods of typing of the bartonellae]. | the primer systems for the pcr detection of four house-keeping genes of bartonellae in clinical material were developed and tested. the tactics of the species rflp typing was also developed and tested. the scheme of the species rflp typing of bartonellae was tested using as an example two strains for the first time isolated in russia from patients with endocarditis and fever of uncertain origin. the results of the typing were supported by sequencing of the amplicons obtained. according to the se ... | 2007 | 17354603 |
| seropositivity rates for bartonella henselae, toxocara canis and toxoplasma gondii in new zealand blood donors. | bartonella henselae, toxocara canis and toxoplasma gondii organisms can all cause vision-threatening posterior segment disease. diagnosis relies heavily on clinical findings, but detection of antibodies in the patient's serum may be helpful in some cases. the significance of a positive serology result depends on the seroprevalence in the general population. seroprevalence rates for these organisms vary widely around the world and this study aimed to determine the rates for a new zealand populati ... | 2007 | 17362453 |
| presumed oculoglandular syndrome from bartonella quintana. | to describe a case of clinically diagnosed oculoglandular syndrome in a 17-year-old patient that was presumed to be due to bartonella quintana, as suggested by a positive serologic titer. | 2007 | 17365807 |
| molecular detection of bartonella species infecting rodents in slovenia. | rodents, collected in three zoogeographical regions across slovenia, were tested for the presence of bartonellae using direct pcr-based amplification of 16s/23s rrna gene intergenic spacer region (its) fragments from splenic dna extracts. bartonella dna was detected in four species of rodents, apodemus flavicollis, apodemus sylvaticus, apodemus agrarius and clethrionomys glareolus, in all three zoogeographic regions at an overall prevalence of 40.4%. the prevalence of infection varied significan ... | 2007 | 17374132 |
| serological testing for bartonella henselae infections in the netherlands: clinical evaluation of immunofluorescence assay and elisa. | cat-scratch disease (csd), caused by bartonella henselae infection, can mimic malignancy and can manifest atypically. reliable serological testing is therefore of great clinical importance. the diagnostic performance of immunofluorescence assay (ifa) and elisa was evaluated in a group of dutch patients with proven csd (clinical diagnosis confirmed by pcr). sera of 51 csd patients and 56 controls (patients with similar symptoms, but who were b. henselae pcr-negative and had an alternative confirm ... | 2007 | 17378931 |
| development of discriminatory multiple-locus variable number tandem repeat analysis for bartonella henselae. | bartonella henselae is a zoonotic bacterium that infects cats and humans. several attempts have been made to develop typing techniques for epidemiological purposes; however, most of the techniques developed do not appear to be sufficiently discriminatory or easy to use. in order to develop multilocus variable number tandem repeat (vntr) analysis (mlva) for b. henselae, 30 vntr candidates were selected from the genome sequence of the reference strain houston 1 (h1). the vntr candidates were initi ... | 2007 | 17379723 |
| evaluation of pulsed-field gel electrophoresis and multi-locus sequence typing for the analysis of clonal relatedness among bartonella henselae isolates. | pulsed-field gel electrophoresis (pfge) represents the gold standard among band-based methods for the molecular typing of bartonella henselae. smai and noti have been frequently used for typing b. henselae by pfge. however, their appropriateness for the analysis of genetic relatedness among b. henselae isolates has not been assessed systematically hitherto. aim of the present study was to evaluate smai, noti, and three additional endonucleases for typing b. henselae isolates by pfge and to compa ... | 2007 | 17398157 |
| chronic vasculitis and polyneuropathy due to infection with bartonella henselae. | bartonella henselae, the causative agent of cat scratch disease and bacillary angiomatosis, is associated with an expanding spectrum of diseases. here, we report on a 40-year-old patient suffering from chronic recurrent painful ulcers of the toes, distal axonal sensomotor polyneuropathy and raynaud's phenomenon. biopsy of the sural nerve demonstrated an axonal neuropathy with a neurogenic muscular atrophy. treatment with high dose corticosteroids had no beneficial effect. a biopsy taken from a r ... | 2007 | 17401716 |
| controlled trial of a 5-day course of telithromycin versus doxycycline for treatment of mild to moderate scrub typhus. | new antibiotics are required to have the antibacterial activity against doxycycline-resistant orientia tsutsugamushi. an in vitro sensitivity study showed that telithromycin was more effective than erythromycin for rickettsia, bartonella, and coxiella burnetii. in this prospective, open-label, randomized trial, we enrolled patients with mild-to-moderate scrub typhus. we compared the efficacy and safety of a 5-day telithromycin therapy with those of a 5-day doxycycline therapy at chosun universit ... | 2007 | 17404000 |
| presence of bartonella spp. in various human populations. | bartonella spp. bacteria are significant human pathogens and the agents of bacterial zoonosis acquired from an animal companion. the aim of the study was to determine the seroprevalence of two of the most common bartonella species b. henselae and b. quintana in various human populations. the studied groups included: alcoholics, intravenous drug users, veterinarians, cats' owners. blood samples were collected and cultured on chocolate agar plates and in mouse fibroblasts l-929 cell line culture. ... | 2007 | 17419187 |
| bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues. | cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. two suggestive episodes of bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. the first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. both episodes were characterized by a very pro ... | 2006 | 17420917 |
| analysis of the first australian strains of bartonella quintana reveals unique genotypes. | bartonella quintana is increasingly recognized as a cause of clinical disease in various geographical locations. we characterized three australian strains associated with endocarditis, using established molecular-typing techniques, the 16s/23s rrna intergenic spacer (its) region, and multispacer typing (mst). all strains examined demonstrated novel its and/or mst genotypes. further characterization of australian strains is required to determine whether there is an association between genotype an ... | 2007 | 17428928 |
| [atypical cat scratch disease in an immunocompetent school-aged child]. | | 2007 | 17430722 |
| from cat scratch disease to endocarditis, the possible natural history of bartonella henselae infection. | most patients with infectious endocarditis (ie) due to bartonella henselae have a history of exposure to cats and pre-existing heart valve lesions. to date, none of the reported patients have had a history of typical cat scratch disease (csd) which is also a manifestation of infection with b. henselae. | 2007 | 17442105 |
| [painful soft-tissue swelling of the upper arm]. | cat-scratch disease is an infection by bartonella henselea and resolves spontaneously. we present a case of untypical bartonella infection which was misinterpreted by mri as a soft-tissue sarcoma of the upper arm. the histological findings of an incision biopsy were unspecific, without signs of malignancy. the tumor was excised completely and the final histology, however, showed no evidence of malignant changes. the bartonella henselae infection could be confirmed by polymerase chain reaction. t ... | 2008 | 17443304 |
| [generalized lymphadenitis associated with hashimoto's thyroiditis]. | a 26-year-old pakistani woman was admitted to hospital with fever, nausea and vomiting, abdominal pain and general weakness for the previous two weeks, but no diarrhea or constipation. antibiotic therapy as an out-patient had not provided relief. she also had enlarged cervical lymph nodes. she reported that she had always been in good health before onset of the described symptoms. | 2007 | 17443443 |
| emerging zoonoses and vector-borne infections affecting humans in europe. | the purpose of this study was to assess and describe the current spectrum of emerging zoonoses between 2000 and 2006 in european countries. a computerized search of the medline database from january 1966 to august 2006 for all zoonotic agents in european countries was performed using specific criteria for emergence. fifteen pathogens were identified as emerging in europe from 2000 to august 2006: rickettsiae spp., anaplasma phagocytophilum, borrelia burgdorferi, bartonella spp., francisella tula ... | 2007 | 17445320 |
| [pediatric pneumonia, pleural effusion, and pericarditis following cat scratch disease and serological cross-reactions among bartonella henselae and rickettsia japonica determined by indirect fluorescence antibodies]. | cat scratch disease is associated with a variety of systemic manifestations. we report a pediatric case associated with pneumonia, pleural effusion, and pericarditis. a 3-year-old boy developed prolonged fever unresponsive to antibiotic treatment, including azithromycin and minocycline. although the fever resolved with corticosteroid treatment, bartonella henselae igg titer was positive in indirect fluorescence antibodies, as was rickettsia japonica igg titer. both titers were significantly redu ... | 2007 | 17447481 |
| molecular mechanisms of resistance to antibiotics in bartonella bacilliformis. | bartonella bacilliformis is the aetiological agent of carrion's disease. although ciprofloxacin, rifampicin and erythromycin have been successfully used in the treatment of the disease, failures and relapses have been reported. the objective of our study was to select in vitro mutants resistant to antibiotics in order to determine the frequency of mutations and to characterize the mechanism of resistance at the molecular level. | 2007 | 17449882 |
| [bacillary angiomatosis caused by bartonella quintana in an human immunodeficiency virus positive patient]. | we report the first case of bacillary angiomatosis due to bartonella quintana affecting a chilean a hiv positive patient in chile. he was a 27 years old, heterosexual male, indigent man known to be hiv positive serological status known from september, 2003, under irregular medical control. on april, 2005, he presented a progressive abscess in the frontal region and erythematous papules in the extremities, that extended to face, thorax and mucoses, becoming nodular and violaceous lesions. bacilla ... | 2007 | 17453076 |
| bartonella henselae infection presenting as a unilateral acute maculopathy. | the purpose of this article is to report an unusual ocular manifestation of cat scratch disease (csd) presenting as a unilateral acute maculopathy (uam). we describe and review the clinical, laboratory, fluorescein angiography (fa), indocyanine green angiography (icg) and optical coherence tomography (oct) records of a patient with csd. | 2007 | 17458800 |
| detection of opportunistic infections by low-density microarrays: a diagnostic approach for granulomatous lymphadenitis. | in molecular diagnosis of infectious diseases often more than 1 pathogen has to be considered. as a consequence, a series of labor-intensive and time-consuming polymerase chain reaction (pcr) approaches specific for different putative pathogens have to be carried out. to speed up diagnosis, we established a low-density microarray for simultaneous detection of diverse putative pathogens causing a disease such as granulomatous lymphadenitis. nucleic acids from formalin-fixed, paraffin-embedded tis ... | 2007 | 17471154 |
| idiopathic facial aseptic granuloma: a multicentre prospective study of 30 cases. | idiopathic facial aseptic granuloma (ifag) was recently described in a single-centre retrospective study as a skin condition that occurs specifically in childhood. | 2007 | 17493068 |
| cat scratch disease from a domestic dog. | cat scratch disease (csd), caused by bartonella henselae, is a zoonosis and characterized by self-limited lymphadenopathy. it is transmitted commonly by scratch or bite from cats or kitten. we report an unusual case of csd caused by a domestic dog scratch that we believe is the first report in taiwan. a 23-year-old healthy woman developed cervical lymphadenopathy, mild fever, headache, and malaise 3 days after dog scratch. her symptoms improved after azithromycin treatment. serology proved b. he ... | 2007 | 17493900 |
| unusual concurrent detection by polymerase chain reaction of bartonella henselae and parvovirus b19 in an immunocompetent child with erythema nodosum and hepatic granulomatous disease. | we report an unusual case of documented bartonella henselae genotype i from hepatic tissue in an italian immunocompetent girl presenting with erythema nodosum and hepatic granulomata. polymerase chain reaction (pcr) was performed on biopsied liver sample to confirm the etiologic role of b. henselae and to identify the genetic variant of this organism. a pcr on the same liver biopsy for parvovirus b19 was also positive, but the clinical meaning of this was not clear. | 2007 | 17532594 |
| prolonged follow up of seven patients affected by hepatosplenic granulomata due to cat-scratch disease. | this study is a retrospective analysis of seven patients with hypoechogenic lesions in the liver and/or spleen due to bartonella henselae, who were followed from 1998 through to 2005 by the department of pediatrics, turin university. in addition to showing constitutional symptoms, four children had skin lesions suggestive of injuries inflicted by cats, and one child had a history of exposure to cats. the origin of the infection remained undefined in the other two patients. humoral tests enabled ... | 2008 | 17541640 |
| two cases of endocarditis due to bartonella henselae. | | 2007 | 17546106 |
| bartonella-related pseudomembranous angiomatous papillomatosis of the oral cavity associated with allogeneic bone marrow transplantation and oral graft-versus-host disease. | patients undergoing allogeneic stem cell transplantation are at high risk for infection with a variety of pathogens during different phases of the procedure. human infections due to bartonella spp. are viewed as emerging diseases typical in, although not exclusive to, immunosuppressed patients, in particular those with aids, organ transplants and haematological malignancies. we describe four patients, three children and one adult, who developed vegetating papillomatous lesions exclusively on the ... | 2007 | 17553040 |
| bartonella species in blood of immunocompetent persons with animal and arthropod contact. | using pcr in conjunction with pre-enrichment culture, we detected bartonella henselae and b. vinsonii subspecies berkhoffii in the blood of 14 immunocompetent persons who had frequent animal contact and arthropod exposure. | 2007 | 17553243 |
| gray foxes (urocyon cinereoargenteus) as a potential reservoir of a bartonella clarridgeiae-like bacterium and domestic dogs as part of a sentinel system for surveillance of zoonotic arthropod-borne pathogens in northern california. | two species of bartonella, a novel bartonella clarridgeiae-like bacterium and b. vinsonii subsp. berkhoffii, were isolated from rural dogs and gray foxes in northern california. a novel b. clarridgeiae-like species was isolated from 3 (1.7%) of 182 dogs and 22 (42%) of 53 gray foxes, while b. vinsonii subsp. berkhoffii was isolated from 1 dog (0.5%) and 5 gray foxes (9.4%). pcr and dna sequence analyses of the citrate synthase (glta) gene and the 16s-23s intergenic spacer region suggested that s ... | 2007 | 17553970 |
| discovery of new infectious diseases - bartonella species. | | 2007 | 17554115 |
| bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species. | bartonella species cause serious human infections globally, including bacillary angiomatosis, oroya fever, trench fever, and endocarditis. we describe a patient who had fever and splenomegaly after traveling to peru and also had bacteremia from an organism that resembled bartonella bacilliformis, the causative agent of oroya fever, which is endemic to peru. however, genetic analyses revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species, closel ... | 2007 | 17554119 |
| [bartonella infection in hematological practice]. | to characterize the clinical and histological features of bartonella infection in patients asking for hematological advice and to assess the significance of serological and molecular methods for the diagnosis of this infection. | 2007 | 17564022 |
| [cat scratch disease]. | | 2007 | 17569180 |
| images in emergency medicine. bartonella henselae lymphadenitis. | | 2007 | 17572294 |
| transcriptional regulation of the heme binding protein gene family of bartonella quintana is accomplished by a novel promoter element and iron response regulator. | we previously identified a five-member family of hemin-binding proteins (hbp's) of bartonella quintana that bind hemin on the outer surface but share no homology with known bacterial heme receptors. subsequently, we demonstrated that expression of the hbp family is significantly influenced by oxygen, heme, and temperature conditions encountered by the pathogen in the human host and the body louse vector; e.g., we observed a dramatic (>100-fold) increase in hbpc transcript levels in response to t ... | 2007 | 17576755 |
| counterpoint: long-term antibiotic therapy improves persistent symptoms associated with lyme disease. | controversy exists regarding the diagnosis and treatment of lyme disease. patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result of the perception that long-term infection with the lyme spirochete, borrelia burgdorferi, and associated tickborne pathogens is rare or nonexistent. | 2007 | 17578772 |
| bartonella dna in loggerhead sea turtles. | | 2007 | 17582905 |
| canine bartonellosis: serological and molecular prevalence in brazil and evidence of co-infection with bartonella henselae and bartonella vinsonii subsp. berkhoffii. | the purpose of this study was to determine the serological and molecular prevalence of bartonella spp. infection in a sick dog population from brazil. at the são paulo state university veterinary teaching hospital in botucatu, 198 consecutive dogs with clinicopathological abnormalities consistent with tick-borne infections were sampled. antibodies to bartonella henselae and bartonella vinsonii subsp. berkhoffii were detected in 2.0% (4/197) and 1.5% (3/197) of the dogs, respectively. using 16s-2 ... | 2007 | 17583666 |
| utility of mr imaging in cat-scratch neuroretinitis. | about 80% of cat-scratch disease (csd) infections occur in children, and csd neuroretinitis (optic neuropathy with retinal exudates in a "macular star" pattern) mostly occurs in children and young adults. a recent study suggested that csd optic neuropathy has specific features on mr imaging. however, mr imaging findings in csd neuroretinitis are not well described in the pediatric literature. we present a patient with csd neuroretinitis in whom these specific mr imaging features preceded the mac ... | 2007 | 17583805 |
| microarray for serotyping of bartonella species. | bacteria of the genus bartonella are responsible for a large variety of human and animal diseases. serological typing of bartonella is a method that can be used for differentiation and identification of bartonella subspecies. | 2007 | 17593301 |
| bartonella henselae exists as a mosaic of different genetic variants in the infected host. | bartonella henselae is a fastidious bacterium associated with infections in humans and cats. the mechanisms involved in the long-term survival of bartonellae despite vigorous host immune responses are poorly understood. generation of genetic variants is a possible strategy to circumvent the host specific immune responses. the authors have recently demonstrated the coexistence of different genetic variants within the progeny of three primary b. henselae isolates from berlin by pfge analysis. aims ... | 2007 | 17600049 |
| bartonella quintana lipopolysaccharide is a natural antagonist of toll-like receptor 4. | bartonella quintana is a gram-negative microorganism that causes trench fever and chronic bacteremia. b. quintana lipopolysaccharide (lps) was unable to induce the production of proinflammatory cytokines in human monocytes. interestingly, b. quintana lps is a potent antagonist of toll-like receptor 4 (tlr4), as it inhibited both mrna transcription and the release of tumor necrosis factor alpha, interleukin 1beta (il-1beta), and il-6 by escherichia coli lps in human monocytes, at ratios ranging f ... | 2007 | 17606598 |
| diagnostic approaches for patients with suspected encephalitis. | encephalitis represents a diagnostic challenge, with an infectious etiology identified in only 40% to 70% of cases. more than 100 agents have been either definitively or anecdotally associated with encephalitis. important considerations for diagnosis include selection of the appropriate clinical specimen (serum vs cerebrospinal fluid), determining the most sensitive diagnostic assay (serology vs polymerase chain reaction), and assessing causality when an organism is identified outside of the cen ... | 2007 | 17618552 |
| evaluation of an internally controlled real-time polymerase chain reaction assay targeting the groel gene for the detection of bartonella spp. dna in patients with suspected cat-scratch disease. | bartonella (b.) henselae is the causative agent of cat-scratch disease (csd), which usually presents as a self-limiting lymphadenopathy. this study reports the development and evaluation of an internally controlled real-time polymerase chain reaction targeting the groel gene for detection of bartonella spp. dna was extracted using the magna pure system. the lower detection limit was 10-100 fg dna and the in vitro sensitivity of the assay was not affected by duplexing with an internal control pcr ... | 2007 | 17624560 |
| phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases. | the beta/alpha-barrel fold type basic amino acid decarboxylases include eukaryotic ornithine decarboxylases (odc) and bacterial and plant enzymes with activity on l-arginine and meso-diaminopimelate. these enzymes catalyze essential steps in polyamine and lysine biosynthesis. phylogenetic analysis suggests that diverse bacterial species also contain odc-like enzymes from this fold type. however, in comparison with the eukaryotic odcs, amino acid differences were identified in the sequence of the ... | 2007 | 17626020 |
| bartonella henselae in ixodes ricinus ticks removed from dogs. | bartonella spp. is an etiologic agent of vector-borne infections. bartonella spp. was searched for in adult ixodes ricinus ticks removed from dogs and cats using specific polymerase chain reaction (pcr) and sequence analysis of glta gene. bartonella henselae dna was detected in 5 of 102 tested ticks. all pcr-positive ticks were removed from dogs. four of were engorged, one was unfed. the data demonstrate that b. henselae is able to inhabit ticks. this is the first report about the existence of b ... | 2007 | 17627437 |
| molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (pcr) and sequencing directly from heart valve tissue. | traditionally, infective endocarditis (ie) has been microbiologically diagnosed by blood cultures or serology. however, conventional microbiologic methods do not always provide an etiologic diagnosis. we conducted the current study to evaluate the usefulness of a universal real-time polymerase chain reaction (pcr) of the 16s rrna gene followed by sequencing for the diagnosis of ie in explanted heart valve tissue (hv) as part of the routine of a clinical microbiology laboratory, and to compare it ... | 2007 | 17632260 |
| vaccines for emerging infections. | emerging infectious diseases represent a grave threat to animal and human populations in terms of their impact on global health, agriculture and the economy. vaccines developed for emerging infections in animals can protect animal health and prevent transmission of zoonotic diseases to humans. examples in this paper illustrate how industry and public health can collaborate to develop a vaccine to prevent an emerging disease in horses (west nile virus vaccine), how poultry vaccination can protect ... | 2007 | 17633303 |
| association of bartonella with the fleas (siphonaptera) of rodents and bats using molecular techniques. | bartonella spp. are putatively vector-borne bacterial agents of humans and animals. fleas have been incriminated as vectors of bartonella spp. and are suspected of transmitting bartonella of rodents and bats, but some of these bartonella spp. have not yet been directly detected in wild caught fleas. we report the molecular detection of bartonella tribocorum, bartonella vinsonii subsp. vinsonii, and two novel genotypes of bartonella from the fleas xenopsylla cheopis, ctenophthalmus pseudagyrtes, ... | 2007 | 17633432 |
| role of magnetic resonance imaging and scintigraphy in the diagnosis and follow-up of osteomyelitis in cat-scratch disease. | cat-scratch disease (csd) is a self-limiting infectious disease characterised with lymphadenopathy in a patient with a history of cat contact. cases of bone involvement in patients with csd are rare. we reported a case of 11-year-old boy with prolonged intermittent fever, inguinal lymphadenopathy and osteomyelitis. he had a history of exposure to kittens. the physical examination revealed a febrile boy without an apparent site of infection except an enlarged inguinal lymph node. its histopatholo ... | 2007 | 17635689 |
| transverse myelitis in 2 patients with bartonella henselae infection (cat scratch disease). | cat scratch disease is usually a benign, self-limiting condition. neurological manifestations are uncommon and may consist of encephalopathy, seizures, and coma. this report describes 2 cases of transverse myelitis: 1 case in a 46-year-old man who had lymph node biopsy and serological testing results that were positive for bartonella henselae and 1 case in a 13-year-old adolescent boy who had serological testing results that were positive for b. henselae. these are 2 of the only 3 cases of trans ... | 2007 | 17638185 |
| ecological differences and coexistence in a guild of microparasites: bartonella in wild rodents. | the study of ecological differences among coexisting microparasites has been largely neglected, but it addresses important and unusual issues because there is no clear distinction in such cases between conventional (resource) and apparent competition. here patterns in the population dynamics are examined for four species of bartonella (bacterial parasites) coexisting in two wild rodent hosts, bank voles (clethrionomys glareolus) and wood mice (apodemus sylvaticus). using generalized linear model ... | 2007 | 17645030 |
| [development of a quantitative real-time polymerase chain reaction for detecting bartonella henselae]. | to develop a quantitative real-time polymerase chain reaction (pcr) for detecting bartonella henselae. | 2007 | 17649663 |
| familial occurrence of cat-scratch disease, with varying clinical expression. | cat-scratch disease, primarily caused by bartonella henselae, typically presents with regional adenopathy, and the role of antibiotics in the treatment is debatable. we present a report of b. henselae infection transmitted by the same kitten to 4 different individuals, each with different clinical characteristics, treatment, and evolution. | 2007 | 17654352 |
| acquisition of nonspecific bartonella strains by the northern grasshopper mouse (onychomys leucogaster). | rodent-associated bartonella species are generally host-specific parasites in north america. here evidence that bartonella species can 'jump' between host species is presented. northern grasshopper mice and other rodents were trapped in the western usa. a study of bartonella infection in grasshopper mice demonstrated a high prevalence that varied from 25% to 90% by location. bartonella infection was detected in other rodent species with a high prevalence as well. sequence analyses of glta identi ... | 2007 | 17672850 |
| bartonella-induced endothelial cell proliferation is mediated by release of calcium from intracellular stores. | the facultative intracellular bacterium bartonella henselae induces unique angiogenic lesions in immunocompromised hosts. to determine the role of intracellular calcium pools in b. henselae-induced endothelial cell proliferation, we generated b. henselae-conditioned medium (bcm) and tested the ability of these cell-free proteins to induce human umbilical vein endothelial cell (huvec) proliferation, cxcl8 production, and intracellular ca2+ signals. huvecs incubated with bcm for 3 days had higher ... | 2007 | 17678436 |
| biomedical evaluation of free-ranging ring-tailed lemurs (lemur catta) in three habitats at the beza mahafaly special reserve, madagascar. | complete physical examinations and biomedical sample collection were performed on 70 free-ranging ring-tailed lemurs (lemur catta) from three different habitats in the beza mahfaly special reserve (bmsr), in southern madagascar, to assess the impact of humans and habitat on lemur health. lemurs were chemically immobilized with ketamine and diazepam administered via blow darts for concurrent biomedical, morphometric, and behavioral studies. subsets of the animals had blood analyzed for hematology ... | 2007 | 17679503 |
| seroprevalence of bartonella henselae in dogs and cats in sassari. | | 2007 | 17682904 |
| mixed infections, cryptic diversity, and vector-borne pathogens: evidence from polygenis fleas and bartonella species. | coinfections within hosts present opportunities for horizontal gene transfer between strains and competitive interactions between genotypes and thus can be a critical element of the lifestyles of pathogens. bartonella spp. are alphaproteobacteria that parasitize mammalian erythrocytes and endothelial cells. their vectors are thought to be various biting arthropods, such as fleas, ticks, mites, and lice, and they are commonly cited as agents of various emerging diseases. coinfections by different ... | 2007 | 17693558 |
| [abscessing lymphadenitis in a 1.5-year-old boy]. | at present, bartonella species are increasingly important as infectious agents in both animals and humans. bartonella henselae, the most frequently diagnosed species, is known to cause numerous clinical syndromes in both immunocompetent and immunocompromised patients. in healthy individuals, the infection is most commonly manifested as the so-called cat scratch disease. the manifestations include erythema or papule at the point of entry of infection (site of injury) and regional lymphadenitis. t ... | 2007 | 17703405 |
| prevalence of serum antibodies against bartonella species in the serum of cats with or without uveitis. | bartonella henselae has been implicated as a causative agent of chronic uveitis in people and in some cats. the objective of this study was to determine whether bartonella species seroprevalence or titer magnitude varies among cats with uveitis, cats without ocular diseases recorded and healthy cats, while controlling for age and risk of flea exposure based on state of residence. there was no difference in seroprevalence rates or titer magnitude between cats with uveitis and cats with non-ocular ... | 2008 | 17719256 |
| encephalopathy complicated by guillain-barre syndrome and hydrocephalus and associated with acute bartonella quintana infection. | we describe a 16-month-old girl who suffered from encephalopathy leading to intensive care unit hospitalization, complicated by guillain-barre syndrome and hydrocephalus, and who had serologic and molecular evidence of central nervous system infection by b. quintana. the possible association of b. quintana with guillain-barre syndrome and hydrocephalus has not been previously described and demonstrates the growing spectrum of neurologic complications of bartonella spp. infections. | 2007 | 17721391 |
| inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. | degeneration of extracellular matrix of cartilage leads to the production of molecules capable of activating the immune system via toll-like receptor 4 (tlr-4). the objective of this study was to investigate the involvement of tlr-4 activation in the development and progression of autoimmune destructive arthritis. | 2007 | 17763416 |
| evaluation of the association of bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. | gingivostomatitis (gs) is a significant condition in cats because of oral discomfort and associated periodontal disease. several infectious agents have been associated with the presence of gs, but a causal relationship is unclear. the cats in this study were housed together, had a history of flea exposure, and were vaccinated with a modified live fvrcp product. there were nine cats with active gs and 36 unaffected cats at the time of sample collection. serum was tested for feline leukemia virus ... | 2008 | 17766156 |
| characterization of an immunogenic outer membrane autotransporter protein, arp, of bartonella henselae. | bartonella henselae is a recently recognized pathogenic bacterium associated with cat scratch disease, bacillary angiomatosis, and bacillary peliosis. this study describes the cloning, sequencing, and characterization of an antigenic autotransporter gene from b. henselae. a cloned 6.0-kb bcli-ecori dna fragment expresses a 120-kda b. henselae protein immunoreactive with 21.2% of sera from patients positive for b. henselae immunoglobulin g antibodies by indirect immunofluorescence, with 97.3% spe ... | 2007 | 17785470 |
| bartonella vinsonii subsp. berkhoffii endocarditis in a dog from saskatchewan. | a dog referred for lameness was diagnosed with culture-negative endocarditis. antibodies to bartonella spp. were detected. antibiotic treatment resulted in transient clinical improvement, but the dog developed cardiac failure and was euthanized. bartonella vinsonii subsp. berkhoffii genotype iv was identified within the aortic heart valve lesions by pcr amplification and dna sequencing. | 2007 | 17824328 |
| quantitative analysis of proliferation and excretion of bartonella quintana in body lice, pediculus humanus l. | although body louse is a well-known vector of trench fever, the growth kinetics of bartonella quintana in body lice has not been fully understood. we performed a quantitative analysis of bacterial multiplication rate. b. quintana started proliferation in body lice 4 days after ingestion and was constantly excreted in the feces for at least 3 weeks. the number of bacteria in feces reached the maximum 10(7)/louse per day on day 15. the doubling time of b. quintana estimated from logistic regressio ... | 2007 | 17827380 |
| bartonella strains in small mammals from dhaka, bangladesh, related to bartonella in america and europe. | ecological and bacteriologic observations of small mammals captured in dhaka, bangladesh, indicated that bartonella infections occurred in high prevalence among lesser bandicoot rats (bandicota bengalensis), black rats (rattus rattus), and house shrews (suncus murinus). sequence analysis of the citrate synthase gene of bartonella isolates showed that small mammals in bangladesh harbored a diverse assemblage of strains. some cultures were genetically related to bartonella elizabethae, a species i ... | 2007 | 17827381 |