| unusual localisation of chronic arthropathy in lumbar facet joints after parvovirus b19 infection. | human parvovirus b19 infection may be responsible for acute and chronic arthropathy. we present the case of a woman, who developed a severe chronic parvovirus b19 infection with persistence of dna parvovirus b19, which was detected in the serum by polymerase chain reaction (pcr). after intravenous immunoglobulin administration she noted a disappearance of the general symptoms and the virus became undetectable by pcr in the serum. however, 1 month later back pain appeared. magnetic resonance imag ... | 2002 | 12189459 |
| [an older female patient with refractory anemia and hemochromatosis]. | case history and clinical findings: a 69-year-old woman was admitted because of a normocytic anemia. one year before an acute b19 parvovirus infection had been diagnosed, but the anemia was attributed to intestinal bleeding caused by a dysplastic colonic polyp. however, anemia persisted despite polypectomy. there was an excessive elevation of serum ferritin. additional examinations: a bone marrow biopsy and aspirate led to the diagnosis of a myelodysplastic syndrome (pure sideroblastic anemia). ... | 2002 | 12192634 |
| causes of morbilliform rash in a highly immunised english population. | to determine the causes of morbilliform rash and fever in a population with high vaccination coverage for measles and rubella. | 2002 | 12193426 |
| association of symptomatic acute human parvovirus b19 infection with human leukocyte antigen class i and ii alleles. | to determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus b19 infection, we compared human leukocyte antigen (hla) class i and ii alleles in 36 patients with symptomatic acute b19 infection with those in >900 control subjects from northwestern england. the frequency of each of hla-drb1*01 (p=.016), drb1*04 (p=.007), and drb1*07 (p<.0001) alleles was significantly higher in parvovirus b19 patients than in control subjects. in the ... | 2002 | 12195370 |
| [familial transient red cell aplasia from parvovirus b-19 infection]. | in our paediatric clinic we observed a case of transient aplastic crisis caused by parvovirus b19 in a child and his mother, both affected by spherocytic haemolytic anemia. anti-parvovirus igm antibody titre and viral search by pcr were positive. anemia was treated with transfusion of concentrated red blood cells. in case of a family onset of hyperacute anemia it is necessary to consider a bone marrow aplastic crisis of the red series, induced by parvovirus b19, especially if there is notice of ... | 2002 | 12197091 |
| life-threatening human parvovirus b19 infection transmitted by intravenous immune globulin. | infection of human parvovirus b19 (b19) is usually a self-limiting febrile illness, but can sometimes be life-threatening under certain circumstances, such as aplastic crisis in patients with haemolytic anaemia, hydrops fetalis in pregnant women and fulminant hepatitis. b19 can be transmitted through respiratory secretions, transplacentally and by transfusion of blood or blood products. in the present case, administration of intravenous immune globulin (i.v.ig) transmitted b19 infection and cons ... | 2002 | 12199806 |
| [varicella and parvovirus b19 immunity among pregnant women in gijón, spain]. | we aimed at determining the inmunological status regarding varicella and parvovirus b19 in pregnant women in gijón, spain, and its correlation with several clinical and epidemiological parameters. | 2002 | 12200018 |
| acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin. | | 2002 | 12200824 |
| detection of parvovirus b19 dna in solvent-detergent plasma. | | 2002 | 12201848 |
| parvovirus b19 infection of cultured skin fibroblasts from systemic sclerosis patients: comment on the article by ray et al. | | 2002 | 12209545 |
| study of chronic hemolytic anaemia patients in rio de janeiro: prevalence of anti-human parvovirus b19 igg antibodies and the development aplastic crises. | the prevalence of anti-human parvovirus b19 igg antibodies was determined in sera from 165 chronic hemolytic anemia patients, receiving medical care at instituto estadual de hematologia (iehe), rio de janeiro, during the year of 1994. this sample represents around 10% of the chronic hemolytic anemia patients attending at iehe. most of these patients (140) have sickle cell disease. anti-b19 igg antibodies were detected in 32.1% of patients. no statistically significant difference (p > 0.05) was s ... | 2002 | 12219109 |
| nucleic acid testing for emerging viral infections. | the development of new technologies leads to the discovery of new viruses. for each of these new infectious agents, relevance to transfusion, including transmissibility by transfusion, pathogenicity, prevalence in blood donors, persistence and the availability of screening assays needs to be assessed. since 1995, one virus and a new family of viruses have been identified. gb virus-c/hepatitis g virus (gbv-c/hgv), a flavi virus with some homology with and epidemiological features of hcv, is not r ... | 2002 | 12220257 |
| enhanced kinetic extraction of parvovirus b19 structural proteins. | recombinant structural proteins (vp1 and vp2) of the human parvovirus b19 have been expressed simultaneously using the baculovirus expression system to form virus-like particles (vlps) that have potential use as vaccines. in this study, we report optimization of extraction conditions to recover these vlps from cell paste. under hypotonic conditions with neutral ph these vlps were poorly extracted (up to 3% extraction). addition of reducing agents, detergents, salts, and sonication did not improv ... | 2002 | 12226856 |
| a pilot study on the seroprevalence of parvovirus b19 infection. | human parvovirus b 19 (pvb 19) causes aplastic crisis in children with congenital haemolytic anaemia, erythema infectiosum, abortion and stillbirth. since data on pvb 19 prevalence is lacking in india, a pilot study was undertaken to estimate the prevalence of igg antibody in children and adults. | 2002 | 12239835 |
| parvovirus b19-related anemia in hiv-infected patients. | persistent infection with parvovirus b19 (b19) is an important treatable cause of anemia in hiv-infected patients. b19 has a tropism for erythroid progenitors and causes pure red cell aplasia (prca). the failure to produce neutralizing antibodies to the virus following b19 infection in immunodeficient persons may result in persistent viremia and chronic prca (b19-prca). the seroprevalence rates for b19 in unselected persons with hiv infection are high, similar to those seen in the general popula ... | 2000 | 12240888 |
| eradication of parvovirus b19 infection after renal transplantation requires reduction of immunosuppression and high-dose immunoglobulin therapy. | | 2002 | 12270996 |
| [significance of viruses in maternal-child morbidity]. | in developing countries infectious diseases continue to be the primary cause of morbidity in children and they are also responsible for an increasing number of untimely deaths. viral, bacterial, mycotic, and parasitic agents are responsible for various pathological conditions that are present in the most vulnerable groups of the population. poverty, crowding, lack of access to potable water, low level of education, and inadequate disposition of excreta provide an ideal environment for infectio ... | 1990 | 12291425 |
| red cell aplasia due to parvovirus b19 in a patient treated with alemtuzumab. | | 2002 | 12358942 |
| parvovirus b19-associated pure red cell aplasia in chronic graft-versus-host disease. | | 2002 | 12358943 |
| identification and characterization of a second novel human erythrovirus variant, a6. | parvovirus b19 (b19), currently the only accepted member of the erythrovirus genus, is the only parvovirus known to be pathogenic in humans. recently a viral sequence, tentatively termed v9 which showed 11% variability from the published b19 sequences, was described from a patient with aplastic crisis. to search for additional parvovirus variants, we used the new ns1/7.5ec pcr assay whose primers were designed from a conserved region of the b19/v9 sequence and encompasses an mfei restriction enz ... | 2002 | 12359439 |
| parvovirus b19 infection in pregnancy. | (1) to review the effects of parvovirus b19 on the pregnant woman and fetus, and (2) to discuss the management of women who are exposed to, who are at risk of developing, or who develop parvovirus b19 infection in pregnancy. | 2002 | 12360369 |
| parvovirus b19 infection associated with myelosuppression and cutaneous polyarteritis nodosa. | | 2002 | 12364654 |
| chronic human parvovirus b19 infection in rheumatic disease of childhood and adolescence. | parvovirus b19 causes erythema infectiosum in children, but the virus is associated with an increasing range of different diseases. about 20% of infections are associated with delayed virus elimination and viremia persisting over several months or years. these persistent b19-infections are characterised by the presence of igg against the non-structural protein ns1. this study aimed to find further evidence for an association of parvovirus b19 persistence with vp1/2- and ns1-specific igg-antibodi ... | 2002 | 12367647 |
| presence of parvovirus b19 dna in chronic urticaric and healthy human skin. | the etiology of chronic urticaria is undefined, but the potential role of infectious agents as one triggering factor has been suggested. the appearance of chronic urticaria in a 16-year old male after a history of a recent parvovirus b19 (b19) infection led us to investigate the association between b19 and chronic urticaria. | 2002 | 12367657 |
| detection of human parvovirus b19 infection: a study of 212 suspected cases in the state of rio de janeiro, brazil. | parvovirus b19 infections are associated with different clinical manifestations that vary from symptom-less to severe. the main clinical manifestations are erythema infectiosum or fifth disease, transient aplastic crisis in individuals with hemoglobinopathies, chronic anemia in the immunocompromised, acute polyarthralgia syndrome in adults, hydrops fetalis, spontaneous abortion and stillbirth. although the classical features of b19 and rubella infections are distinct, uncommon presentations can ... | 2002 | 12367658 |
| [parvovirus b19 outbreak in a rural community in alicante]. | parvovirus b19 (pvb19) has been identified as the cause of erythema infectiosum. the epidemiology of pvb19 has not been extensively studied in spain or in the autonomic community of valencia. the aim of this work is to describe an outbreak of pvb19 infection occurring in the area of monforte del cid, alicante. | 2002 | 12372232 |
| virus safety of human blood, plasma, and derived products. | the reconstitution of blood and its components is hampered by factors of compatibility, availability, and the risk of transmission of infectious diseases. protozoal agents such as plasmodium malariae and trypanosoma cruzi are only regionally relevant. bacterial transmissions are easy to prevent and treat. antibody, antigen, and nucleic acid screening have been implemented to prevent transmission of blood-borne viruses. transfusion-relevant viruses include hepatitis b and c virus (hbv and hcv), h ... | 2002 | 12379292 |
| quality of therapeutic plasma-requirements for marketing authorization. | fresh frozen plasma (ffp) contains higher levels of intact coagulation factors and coagulation and fibrinolysis inhibitors than solvent/detergent-treated plasma (sd plasma), and also greater residual cell contamination. sd plasma is a particle-free plasma of uniform quality. sd treatment, however, has the specific result of reducing the activities of some inhibitors. both plasma types carry a minimal residual risk of transmitting human immunodeficiency virus (hiv)-1/2, hepatitis virus b (hbv), a ... | 2002 | 12379293 |
| detection of human parvovirus b19 infection in first-trimester fetal loss. | | 2002 | 12383563 |
| active, fulminant, lethal myocarditis associated with parvovirus b19 infection in an infant. | we report a case of fulminant myocarditis in an 11-month-old female infant who had no other clinical signs of parvovirus infection. the patient presented with severe respiratory distress and died in sudden cardiac arrest 3 h after admission. the clinical presentation was similar to that of an asthmatic attack. autopsy revealed signs of acute lymphocytic myocarditis. parvovirus dna was demonstrated by polymerase chain reaction (pcr) analysis of tissue sections obtained from the heart, lungs, live ... | 2002 | 12384834 |
| revised clinical presentation of parvovirus b19-associated intrauterine fetal death. | adverse pregnancy outcome due to human parvovirus b19 (hereafter referred to as "parvovirus b19") has been characterized, in numerous reports, as an event that occurs during the first and second trimesters and is strongly associated with symptoms of fetal hydrops. recent findings have indicated that parvovirus b19-associated intrauterine fetal death (iufd) is also a problem in late gestation, although its clinical presentation is aberrant, lacking signs of fetal hydrops. we outlined the clinical ... | 2002 | 12384835 |
| removal of neutralized model parvoviruses and enteroviruses in human igg solutions by nanofiltration. | nanofiltration has proven to be an effective technology for virus removal. the small nonenveloped viruses, such as hav and parvovirus b19 (b19), are evidently more difficult to remove than the larger enveloped viruses. however, since antibodies against these viruses, hav and b19, are constantly present in large plasma pools, it is conceivable that antibody binding will lead to an increase in size of the viruses due to a corona of antibodies on the virus surfaces. these enlarged viruses should be ... | 2002 | 12385411 |
| inactivation of parvovirus b19 during pasteurization of human serum albumin. | it has been shown that hsa may be contaminated with parvovirus b19 (b19) dna. however, the presence of b19 dna does not necessarily indicate infectious virus. hsa is pasteurized at 60 degrees c for 10 hours and it remains unclear whether this procedure inactivates b19. studies with animal parvoviruses indicate considerable heat resistance at 60 degrees c. however, due to the lack of a suitable cell culture system, the pasteurization process has not been investigated in the past. | 2002 | 12385412 |
| human parvovirus b19 infection in children: uncommon clinical presentations. | human parvovirus b19 is responsible for a variety of clinical syndromes, such as erythema infectiosum, non-immune hydrops fetalis, transient aplastic anemia, and arthropathies. hpv is also suspected of playing a role in the pathogenesis of various chronic inflammatory and autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, kawasaki disease and multiple sclerosis. | 2002 | 12389336 |
| parvovirus b19 infection--an emerging infectious disease? | | 2002 | 12389346 |
| chronic human parvovirus b19 infection associated with interstitial lung disease. | | 2002 | 12389353 |
| aplastic anaemia associated with parvovirus b19 infection. | parvovirus b19 involvement was investigated in 30 children with severe aplastic anaemia. active or recent parvovirus b19 infection, as shown by b19 dna viraemia, positive b19 specific igm antibodies, or both, was diagnosed in six patients. there were no other plausible causes. we suggest that parvovirus b19 infection might be associated with severe aplastic anaemia. | 2002 | 12390927 |
| glycosphingolipid expression in acute nonlymphocytic leukemia: common expression of shiga toxin and parvovirus b19 receptors on early myeloblasts. | glycosphingolipids (gsls) are complex macromolecules on cell membranes that have been shown to play a role in neutrophil differentiation, activation, phagocytosis, and adhesion to both microorganisms and vascular endothelium. because gsls are often cryptic antigens on cell membranes, little is known regarding gsl expression in early myelopoiesis. to study the latter, myeloblasts were collected from patients with acute nonlymphocytic leukemia (anll) who required therapeutic leukocytopheresis for ... | 2003 | 12393713 |
| gloves and socks syndrome: early and late histopathologic features. | gloves and socks syndrome (gss) is a recently described exanthem, most commonly caused by parvovirus b19. | 2002 | 12399769 |
| human parvovirus b19 infection in pregnancy: should screening be offered to the low-risk population? | human parvovirus b19 infection during pregnancy can result in fetal hydrops and death. intra-uterine transfusion in hydropic fetuses affected by the virus can reduce perinatal deaths. up to 33% of women with this infection are asymptomatic. in view of the significant adverse outcomes, the role of routine screening among low-risk pregnant women is discussed. | 2002 | 12403278 |
| human parvovirus bb19 detection in asymptomatic blood donors: association with increased neopterin concentrations. | serum neopterin concentrations were determined in 20,000 blood donations. for the 400 donations with neopterin concentrations above the 98 th percentile and another 1200 donations with neopterin concentrations in the lower range, results of human parvovirus (hpv) b19 tests were compared. infectious specimens were identified by dot blot hybridization assay and polymerase chain reaction (pcr) that used the outer primers and detected 1 pg of hpv b19 dna, corresponding to approximately 10(5) copies ... | 2002 | 12404168 |
| increased risk of parvovirus b19 infection in young adult cancer patients receiving multiple courses of chemotherapy. | an increased human parvovirus b19 infection rate has been observed in immunocompromised hosts. in this study, we sought to determine the prevalence of parvovirus b19 infection in adult cancer patients receiving multiple courses of systemic chemotherapy. from march 1999 through april 2000, 59 men and 68 women, with a median age of 49 (18 to 79) years, were enrolled in this study. they had received an average of 7.1 (4 to 32) courses of systemic chemotherapy. the median duration from the date of s ... | 2002 | 12409350 |
| the role of infectious agents in the pathogenesis of systemic sclerosis. | over the past few years, increasing evidence has accumulated to implicate infectious agents in the etiology of systemic sclerosis (ssc) and raynaud phenomenon. infection rates in patients with ssc compared with those in control populations do not provide clear support for any specific pathogen. however, increased antibody titers, a preponderance of specific strains in patients with ssc, and evidence of molecular mimicry inducing autoimmune responses suggest mechanisms by which infectious agents ... | 2002 | 12410093 |
| chronic pure red cell aplasia associated with parvovirus b19 infection in an immunocompetent patient. | | 2002 | 12410591 |
| spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus b19 infection and concomitant epstein-barr virus reactivation in an otherwise healthy adult. | reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute b19 infection and concomitant epstein-barr virus reactivation. the previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. immunoglobulin (ig) m antibodies to epstein-barr virus (ebv) capsid antigen, early antigen and parvovirus b19 (b19) were found. b19 dna and low-level ebv dna ... | 2002 | 12415473 |
| parvovirus b19 transmission by heat-treated clotting factor concentrates. | human parvovirus b19 (b19) dna can be frequently detected in plasma-derived coagulation factor concentrates. the production of some clotting factor products includes heat treatment steps for virus inactivation, but the effectiveness of such steps for b19 inactivation is unclear. moreover, detailed transmission case reports including dna sequence analysis and quantification of b19 dna from contaminated heat-treated blood components have not been provided so far. therefore, the correlation between ... | 2002 | 12421221 |
| transient pancytopenia associated with parvovirus infection in a healthy child. | | 2002 | 12421275 |
| donor-transmitted parvovirus infection in a kidney transplant recipient presenting as pancytopenia and allograft dysfunction. | parvovirus b19 is a nonenveloped single-stranded dna virus that commonly causes a benign childhood infection typically manifesting as a "slapped-cheek" rash. in immunodeficient hosts, this infection can cause persistent anemia and occasionally pancytopenia. recently, direct renal involvement has been reported in renal transplant recipients leading to various forms of glomerulopathy and allograft dysfunction. most cases are primary infections and are donor transmitted through the transplanted org ... | 2002 | 12421463 |
| confirmation of an outbreak of parvovirus b19 in a primary school using igm elisa and pcr on thumb prick blood samples. | although parvovirus infections are usually benign and self-limiting, it is important to confirm the diagnosis in a public health setting which might involve pregnant women and in which an outbreak could lead to medical consequences. in these situations, microbiological confirmation by thumb prick is a relatively low-invasive method that is simple to carry out. | 2002 | 12423694 |
| detection of parvovirus b19 dna by polymerase chain reaction in giant cell arteritis: a case-control study. | | 2002 | 12428256 |
| nat screening of blood and plasma donations: evolution of technology and regulatory policy. | | 2002 | 12430684 |
| retrospective analysis of non-a-e hepatitis: possible role of hepatitis b and c virus infection. | in an effort to determine the cause of non-a-e hepatitis, a retrospective study was undertaken on a group of patients with hepatitis but without serological infection markers of hepatitis viruses a-e. a total of 60 patients admitted to beijing ditan hospital during the period of september 1997 and september 1999 were chosen for this study. these patients were diagnosed as either acute or chronic hepatitis, but no serological markers of hepatitis viruses a-e were detected. since tt virus (ttv), h ... | 2003 | 12436478 |
| analysis of b19 virus contamination in plasma pools for manufacturing, by using a competitive polymerase chain reaction assay. | the presence of b19 virus in blood poses a risk of transmission of the virus via blood or blood products. screening processes for manufacturing should be aimed at achieving production plasma pools with b19 virus contamination levels below 104 genome equivalents/ml (geq/ml) in order to prevent transmission of infection through plasma derivatives. | 2002 | 12437519 |
| evidence for the role of demyelination, hla-dr alleles, and cytokines in the pathogenesis of parvovirus b19 meningoencephalitis and its sequelae. | to review the clinical and pathological features of parvovirus b19 meningoencephalitis and its sequelae in 12 previously published cases, and to perform additional tests to determine the pathogenesis of the disease. | 2002 | 12438480 |
| noninvasive diagnosis by doppler ultrasonography of fetal anemia resulting from parvovirus infection. | the purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus b19 infection. | 2002 | 12439522 |
| acute parvovirus b19 infection and anemia during plasmodium falciparum malaria. | | 2002 | 12439818 |
| a new parvovirus genotype persistent in human skin. | parvovirus b19 is the exclusive human pathogen of the erythrovirus genus. in classical view, the b19 dna sequence shows little variability, with no disease-specific or tissue type specific associations. we examined skin biopsies from patients with b19-unrelated skin disease or from constitutionally healthy adults by polymerase chain reaction assays for four different genomic regions of the b19 virus. sequencing showed that the skin-derived viral dna differed within the protein-coding region from ... | 2002 | 12441066 |
| evaluation of anti-parvovirus b19 activity in sera by assay using quantitative polymerase chain reaction. | human parvovirus b19 (b19) infects cells of erythroid lineage. production of neutralizing antibodies (abs) is indispensable for recovery from b19-related disease state. in this study, we used a convenient method to measure neutralizing activities in human sera by using a real-time quantitative pcr based assay. erythroid cell line ku812ep6 was incubated with test sera before infection with b19 virus. the copy number of b19-dna in cultures was decreased in the presence of the sera from patients wh ... | 2003 | 12445941 |
| erythrovirus b19 infection in humans. | erythrovirus b19 (b19) previously called parvovirus b19 is the only human pathogen in the family parvoviridae. b19 is an autonomously replicating small single stranded non-enveloped dna of 5.5 kb with hairpin termini through which it replicates, when the cells are in the s-phase. virus host interactions are mediated through the capsid protein vp2 attaching to p antigen receptor expressed on certain host cells, which imparts narrow host and tissue tropism. it affects the progenitor red cells, meg ... | 2000 | 12452123 |
| neurodevelopmental outcome after intrauterine red cell transfusion for parvovirus b19-induced fetal hydrops. | to assess long term neurodevelopmental outcome of children after intrauterine intravascular red cell transfusion (jut) for parvovirus b19-induced fetal hydrops. | 2002 | 12452460 |
| parvovirus b19 associated adult henoch schönlein purpura. | parvovirus b19 has recently been implicated in various vasculitic syndromes including henoch schönlein purpura (hsp), wegener's granulomatosis and microscopic polyarteritis. the association was established through serology, the identification of dna in the peripheral blood and affected tissues and more recently by rna localization to cutaneous capillary endothelium. however, direct localization of the viral dna to the glomerular and cutaneous endothelium in hsp in correlation with the histopatho ... | 2002 | 12453298 |
| virus-related glomerular diseases: histological and clinical aspects. | viral infections can be the causative agent in many glomerular diseases, and diagnostic criteria include clinical and laboratory data and tissue molecular analysis. hepatitis b virus (hbv) is a well known cause of membranous glomerulonephritis (mgn), membranoproliferative gn (mpgn) and iga nephropathy (igan), frequently in asian populations. hepatitis c virus (hcv), besides cryoglobulinemia-mediated glomerulonephritis (gn), is reported to cause other forms of gn. human immunodeficiency virus (hi ... | 2002 | 12455712 |
| acute encephalopathy with parvovirus b19 infection in sickle cell disease. | a 13 year old girl with haemoglobin sbeta(+)thalassaemia developed simultaneous aplastic crisis and encephalopathy associated with parvovirus b19 (pb19) infection. brain magnetic resonance imaging findings were consistent with central nervous system (cns) vasculitis and her symptoms resolved with steroid therapy. thus, pb19 induced cns hypersensitivity vasculitis must be considered in the differential diagnosis of encephalopathy. | 2002 | 12456562 |
| clinical and epidemiological aspects of human parvovirus b19 infection in an urban area in brazil (niterói city area, state of rio de janeiro, brazil). | this study was designed to analyse the clinical and epidemiological data from human parvovirus b19 cases in a six-year study of rash diseases conduct in an urban area in brazil (niterói city area, state of rio de janeiro). a total of 673 patients with acute rash diseases were seen at two primary health care units and at a general hospital. a clotted blood sample was collected from all subjects at the time of consultation. forty-nine per cent (330 cases) of the patients were negative for dengue, ... | 2002 | 12471422 |
| papular purpuric rash due to parvovirus b19 with distribution on the distal extremities and the face. | we describe 3 patients who presented with a distinctive clinical picture of the purpuric rash called "gloves-and-socks syndrome" which was characterized by an acral distribution of the rash that involved not only the distal part of the extremities but also the chin and perioral area. serologic analysis for parvovirus b19 yielded positive results. parvovirus b19 should be included in the evaluation of febrile purpura. | 2002 | 12471578 |
| familial collapsing glomerulopathy: clinical, pathological and immunogenetic features. | collapsing glomerulopathy (cg) is an aggressive form of glomerular injury frequently seen in association with hiv infection, although it is also recognized in non-hiv patients as a primary disease. until now, the occurrence of cg in a familial pattern has not been reported. | 2003 | 12472788 |
| no association between human parvovirus b19 infection and sjögren's syndrome. | | 2003 | 12480682 |
| parvovirus-b19 infection preceding acute myeloid leukemia with orbital granulocytic sarcoma. | we report here an unusual presentation of acute nonlymphoblastic leukemia with ocular granulocytic sarcoma who was firstly diagnosed iron deficiency anemia and acute parvovirus infection induced erythroid hypoplasia. to our knowledge this is the first paper of acute myeloblastic leukemia (aml) with granulocytic sarcoma, preceded by acute parvovirus b19 infection. | 2002 | 12481910 |
| human fetal infection with parvovirus b19: maternal infection time in gestation, viral persistence and fetal prognosis. | to clarify the relation between the time of parvovirus b19 (b19) infection in pregnancy and fetal outcome, including the viral persistence in the fetus. | 2002 | 12488663 |
| parvovirus b19 infection and acute lymphoblastic leukaemia. | | 2003 | 12492595 |
| focal parvovirus b19 myocarditis in a patient with brugada syndrome. | the brugada syndrome is characterized by a distinct ecg pattern consisting of st segment elevation in the right precordial leads and right bundle branch block, a propensity for life-threatening arrhythmias, and an apparently structurally normal heart. the authors describe the case of a patient with an aborted sudden cardiac death and the typical ecg signs of brugada syndrome. nevertheless, magnetic resonance imaging displayed signal enhancement in the left ventricular myocardium. additionally, h ... | 2003 | 12493136 |
| parvovirus b19 infection and igf system components in relation to erythropoiesis in dialyzed patients and kidney transplant recipients. | | 2002 | 12493423 |
| fetal hepatic calcifications: prenatal diagnosis and outcome. | the purpose of this study was to provide information on the causes and postnatal outcomes of fetal liver calcifications that were detected by ultrasound imaging. | 2002 | 12501073 |
| human parvovirus b19-induced cell cycle arrest and apoptosis. | | 2002 | 12503064 |
| [human parvovirus b19 infection which first presented with petechial hemorrhage, followed by papular-purpuric gloves and socks syndrome and erythema infectiosum]. | a case of human parvovirus b19 (b19) infection is reported. a 6-year-old previously healthy girl was admitted to our hospital complaining of slight fever and petechial hemorrhage on her neck, trunk and the proximal parts of extremities. on admission, the platelet count was within normal range (180 x 10(3)/microliter) but white blood cells and reticulocytes were moderately suppressed (2.4 x 10(3)/microliter and 1@1000, respectively). the purpura disappeared in a week and the blood cell counts ful ... | 2002 | 12508481 |
| digital arterial occlusive disease and parvovirus b19 infection. | we report a case of a 37-year-old white woman, who presented with digital arterial occlusions associated with parvovirus b19 infection. two other member of the family presented acute febrile illness, polyarthralgia (husband), and erythema infectiosum (son) during the same month. this new report gives weight to the concept that acute human parvovirus infection could become part of the differential diagnosis of acute digital occlusive arteriopathy. | 2002 | 12510554 |
| [the study on detection of human parvovirus b19 dna in spontaneous abortion tissues]. | 116 spontaneous abortion tissues were detected for human parvovirus b19 (hpv b19) dna by nested polymerase chain reaction. of the abortion tissues detected, 66 were paraffin embedded and 50 were fresh abortion tissues, at the same time, 25 abortion tissues from healthy artificial abortion women were collected as control. the results showed that 27.3% (34/116) of 116 spontaneous abortion tissues were positive for hpv b19 dna, and only 4% (1/25) were positive in the control group, the discrepancy ... | 1998 | 12515197 |
| human parvovirus b19 infection during pregnancy and its possible impact on perinatal outcome in the obstetric population of kuwait. | | 2001 | 12521803 |
| severe prolonged red blood cell aplasia and thrombocytopenia induced by parvovirus b19 infection in a patient with sarcoidosis. | we describe an acromegalic patient who developed a parvovirus b19 (pvb19) infection concomitantly with sarcoidosis, which was complicated by chronic red blood cell aplasia and severe thrombocytopenia, despite disappearance of the virus from serum and the production of high levels of specific polyclonal antibodies to pvb19. mitogen stimulation of the patient's peripheral blood mononuclear cells induced oversecretion of interferon-gamma (ifn-gamma). because hematopoietic suppression by ifn-gamma h ... | 2003 | 12522758 |
| [laboratory diagnostics of infections caused by cytomegalovirus and parvovirus b19 in patients with secondary immunodeficiency]. | to improve the quality of diagnostics and treatment of patients with immunodeficient states, two groups of patients were examined for the presence of cytomegalovirus (cmv) infection, among them 1,348--with clinical manifestations of cmv infection (group 1) and 335 hematological patients (group 2); in addition, 36 patients with secondary immunodeficiency and 31 patients with aplastic and hemolytic anemia, or with anemia of unclear origin were examined for the presence of parvovirusinfection (b19) ... | 2002 | 12525002 |
| parvovirus b19: a pathogen responsible for more than hematologic disorders. | the clinical and pathomorphological patterns of parvovirus b19 (pvb19)-associated diseases is the result of a balance between virus, host target cells and immune response. it is a characteristic feature of pvb19 that in patients with various other preexisting diseases, e.g., many hemolytic anemias, immune complex-mediated vasculitic disorders, and primary or secondary immunodeficiencies, the underlying diseases can be triggered, aggravated or complicated by severe organ manifestations. identific ... | 2003 | 12536309 |
| pure red-cell aplasia due to parvovirus b19 infection in a patient treated with alemtuzumab. | | 2003 | 12560244 |
| fatal parvovirus b19 myocarditis in an 8-year-old boy. | a report is given on an 8-year-old boy who suddenly and unexpected died. autopsy findings point to acute heart failure. microscopic examination of the heart showed increased interstitial and perivasal fibrosis and myocarditis with macrophage infiltration. polymerase chain reaction (pcr) analysis for parvovirus b19 was positive in heart samples and in the spleen. immunostaining for parvoviral surface antigens was negative. although the virus does not appear to have infected the cardiomyocytes, we ... | 2003 | 12570225 |
| [parvovirus b19 infection--a risk factor during pregnancy. asymptomatic course of disease makes the prevention and treatment more difficult]. | | 2003 | 12580007 |
| hydrops fetalis secondary to parvovirus b19 infections. | fetal infection by human parvovirus b19 is a common cause of fetal anemia, nonimmune hydrops fetalis, and spontaneous abortion and can result in fetal death. recent improvements in diagnosing parvovirus infections and the availability of intrauterine transfusion have reduced the overall rate of fetal loss after maternal exposure. | 2003 | 12583652 |
| human parvovirus b19 nonstructural protein (ns1) induces cell cycle arrest at g(1) phase. | human parvovirus b19 infects predominantly erythroid precursor cells, leading to inhibition of erythropoiesis. this erythroid cell damage is mediated by the viral nonstructural protein 1 (ns1) through an apoptotic mechanism. we previously demonstrated that b19 virus infection induces g(2) arrest in erythroid ut7/epo-s1 cells; however, the role of ns1 in regulating cell cycle arrest is unknown. in this report, by using paclitaxel, a mitotic inhibitor, we show that b19 virus infection induces not ... | 2003 | 12584315 |
| parvovirus b19 and "cryptogenic" chronic hepatitis. | | 2003 | 12586308 |
| [laboratory diagnosis of cytomegaloviral infection in patients with anemia and hemoblastosis in the omsk region]. | research was carried out in 335 blood specimens of patients in the age of 3-35 y.o. in order to optimize diagnosis and treatment of such patients with aplastic anemia and hemoblastosis who got hemotransfunction to eliminate cytomegaloviral infection (cmvi). igm were found out in 37.9% cases (2.8 times higher than in donors), low-avide igg--in 44.8%. "early" proteins cmv--29.9% and dna--in 36.8% cases. concerning the dna presence, preference was given to research of leucocytic suspension compared ... | 2002 | 12587556 |
| immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. | the beneficial effect of immunosuppressive treatment on myocarditis is still controversial, possibly because the immunologic and virological profile of potential candidates is largely unknown. | 2003 | 12591756 |
| lack of evidence for a direct involvement of muscle infection by parvovirus b19 in the pathogenesis of inflammatory myopathies: a follow-up study. | to clarify the association between parvovirus b19 and myositis. | 2003 | 12595634 |
| long term follow up of serostatus after maternofetal parvovirus b19 infection. | maternofetal parvovirus b19 infection may result in fetal hydrops or abortion. chronic infection has been associated with long term complications (polyarthritis, persistent aplastic anaemia, hepatitis). in pregnancy maternal immunosuppression caused by a th2 dominant response to viral antigens has been observed. there is little information on long term reactivity to intrauterine infection. | 2003 | 12598382 |
| safety and immunogenicity of a recombinant parvovirus b19 vaccine formulated with mf59c.1. | a recombinant human parvovirus b19 vaccine (medi-491; medimmune) composed of the vp1 and vp2 capsid proteins and formulated with mf59c.1 adjuvant was evaluated in a randomized, double-blind, phase 1 trial. parvovirus b19-seronegative adults (n=24) received either 2.5 or 25 microg medi-491 at 0, 1, and 6 months. medi-491 was safe and immunogenic. all volunteers developed neutralizing antibody titers that peaked after the third immunization and were sustained through study day 364. | 2003 | 12599085 |
| [pure red cell aplasia due to parvovirus b19 occurred in a patient with liver cirrhosis c and hepatocellular carcinoma]. | | 2003 | 12601930 |
| fatal parvovirus b19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease. | we report the case of a 34-year-old female patient who died 4 days after hospital admission of acute heart failure clinically mimicking ischemic heart disease. microscopic examination of the heart showed severe myocarditis. polymerase chain reaction (pcr), including quantitative real-time pcr, disclosed exclusively parvovirus b19 (pvb19), with a high viral load of 4.3x10(5) pvb19 viral genome equivalents per microg myocardial nucleic acid. radioactive in situ hybridization detected viral genomes ... | 2003 | 12605372 |
| the association of pityriasis rosea with cytomegalovirus, epstein-barr virus and parvovirus b19 infections - a prospective case control study by polymerase chain reaction and serology. | a viral aetiology is suspected for pityriasis rosea (pr). the objective was to investigate the association of pr with cytomegalovirus (cmv), epstein barr virus (ebv) and parvovirus b19 infections. patients with pr were recruited in a primary care setting over 18 months. blood was collected at initial presentation and four weeks later. controls were the next age-and-sex-matched patients requiring blood collection for non-dermatological disease. polymerase chain reaction was performed for ebv and ... | 2003 | 12609777 |
| infections preceding early arthritis in southern sweden: a prospective population-based study. | to detect evidence of infections preceding early arthritis in southern sweden and to compare the clinical outcome of remission during a 6-month followup for patients with and without signs of prior infection. | 2003 | 12610801 |
| use of rt-pcr on oral fluid samples to assist the identification of measles cases during an outbreak. | this study investigated the occurrence of mild modified measles cases during an outbreak in niterói, rj, brazil by using rt-pcr on oral fluid samples. from august to december 1997 a total of 76 patients with rash were seen at the study sites. confirmed diagnosis by serology was achieved in 47 cases: measles (39.5%), rubella (13.2%), hhv-6 (3.9%), human parvovirus b19 (3.9%), dengue fever (3%). for 19 of the 29 patients without a conclusive diagnosis paired serum and saliva samples were available ... | 2003 | 12613751 |
| [perinatal infections of b19 parvoviruses] | this study is aimed at detecting perinatal infections of parvovirus b19 (pv b19). the authors have analyzed specific antibodies (igm and igg) in the cord serum of 647 babies, born consecutively at the st. eugenio hospital in rome. 156 of them (24%) were positive to igg. the analysis of viral genome by pcr methods showed three positive subjects (2%). the three newborn babies did not develop any pathologies during a two-year follow-up and pcr became negative within the first 6 months. data show th ... | 2002 | 12616272 |
| identification of a nonconventional motif necessary for the nuclear import of the human parvovirus b19 major capsid protein (vp2). | human parvovirus b19 replicates and encapsidates its genome in the nucleus of erythroid progenitors in vivo and in vitro. we wanted to understand the determinants necessary for the nuclear transport of the major coat protein, vp2, which makes up about 96% of the viral capsid proteins. a nonconsensus basic motif, klgprkatgrw, necessary for the nuclear localization of vp2 was identified and shown to be able to import reporter proteins into the nucleus. the sequence is conserved among the vp2 c-ter ... | 2003 | 12620794 |
| b19 virus infection in renal transplant recipients. | b19 virus infection with persistent anaemia has been reported in organ transplant recipients. detection of b19 virus dna in serum is the best direct marker of active infection. | 2003 | 12637086 |