| supersensitivity of hippocampal neurons to acidic amino acids in decommissurized rats. | | 1977 | 11874 |
| alkaline phosphatase activity, characterization, and subcellular distribution during initial skeletogenesis in the prenatal rat limb. | the specific activity, tissue specificity, and subcellular distribution of alkaline phosphatase were studied in the fetal rat limb during initial cartilage calcification and bone formation. the ph optimum, km, activation, and inhibition characteristics of the enzyme assayed for in 900 x g supernates of whole limb homogenates indicated that the activity represented a fetal bone alkaline phosphatase. studies examining temporal changes of the enzyme in these preparations demonstrated a substantial ... | 1976 | 11876 |
| increased guanylate cyclase activity and guanosine 3',5'-monophosphate content in ethionine-induced hepatomas. | ethionine-induced hepatomas are characterized by high adenylate cyclase activity and cyclic adenosine 3',5'-monophosphate content relative to those of surrounding liver or liver from pair-fed control rats. the present study examined the properties of the guanylate cyclase-cyclic guanosine 3',5'-monophosphate (cgmp) system of these tissues. cgmp levels of the ethionine-induced hepatomas, determined in both specimens quick-forzen in situ and after in vitro incubation of tissue slices, were approxi ... | 1977 | 11887 |
| activation of guanylate cyclase by streptozotocin and 1-methyl-1-nitrosourea. | streptozotocin has been shown to induce the production of a variety of tumors in rats. the present report demonstrates that streptozotocin and 1-methyl-1-nitrosourea, a component of the streptozotocin molecule and a known carcinogen, stimulate the enzyme guanylate cyclase which catalyzes the production of guanosine 3',5'-monophosphate. at a maximal concentration of 3 mg/ml, these agents activated guanylate cyclase approximately 30-fold in liver, 20-fold in kidney, 15-fold in cerebellum. 15- to 3 ... | 1977 | 11888 |
| use of an elemental diet in animals during treatment with 5-fluorouracil (nsc-19893). | rats eating a diet containing casein hydrolysate (10% wt/wt)(diet 3) instead of whole casein (diet 1) exhibited increased tolerance to nine consecutive daily injections of 15 mg/kg of 5-fluorouracil (5-fu). the relative nutritional efficiency of diet 3 was significantly higher during 5-fu treatment. serum albumin levels measured after 5-fu treatment dropped by only 2.7% in diet 3 groups and by 13.5% in diet 1 groups. serum albumin values for rats on the control diet (purina lab chow) were compar ... | 1976 | 11889 |
| effects of ergosterol and adrenalectomy on the maintenance of pregnancy in the ovariectomized rat. | | 1977 | 11935 |
| the effect of maleate and lithium on renal function and metabolism. | | 1976 | 11962 |
| the role of hco3-stimulated atpase in buffer transport. | an atpase stimulated by hco-3ions and other oxybases and inhibited by scn- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting hco-3ions. no such atpase was found in the rabbit duct, which normally does not secrete hco-3. the hco-3atpase was localized in the plasma membrane fraction of the homogenate, as evidenced by the marker 5'nucleotidase. the activities of the hco-3atpase increased in metabolic alkalosis and decreased in metabolic acidosi ... | 1976 | 11963 |
| polarity of proximal tubular epithelial cells in relation to transepithelial transport. | transport properties of brush border microvilli and basal-lateral plasma membranes isolated from rat kidney cortex were studied by a millipore filtration technique. brush border microvilli but not basal-lateral plasma membranes contain sodium dependent stereospecific transport system for d-glucose, l-phenylalanine and inorganic phosphate as indicated by saturability, countertransport and inhibition by structurally related compounds. reduction of equilbrium uptake by increasing medium osmolarity ... | 1976 | 11964 |
| properties of rat kidney glutaminase enzymes and their role in renal ammoniagenesis. | rat kidney contains two distinct glutaminase activities; the mitochondrial phosphate-dependent glutaminase and a second glutaminase activity associated with the brush border membrane which is maleate-activated and phosphate-independent. it has recently been shown that the phosphate-independent glutaminase is a partial reaction of gamma-glutamyl transpeptidase and that maleate activates this enzyme by blocking transpeptidation. the gamma-glutamyl transpeptidase in other rat tissues is also affect ... | 1976 | 11965 |
| on the role of gamma-glutamyltransferase in renal tubular amino acid reabsorption. | the degradation of glutathione in the kidney of the rat was investigated in vivo and in vitro. when radioactive glutathione or its analogue ophthalmic acid was administered intravenously to mice or rats, the tripeptides were rapidly and completely degraded. within the organs, no radioactive glutathione, but only labelled glycine was found. the main part of the degrading activity was localized in the kidney. kidney homogenate degraded glutathione at a rate of 46.5 nmoles/min per mg of protein. th ... | 1976 | 11966 |
| the influence of branched chain aminoacids and their ketoderivatives on renal gluconeogenesis. | isolated kidney tubules served as a model to investigate the direct effect of branched chain aminoacids and their ketoderivatives on gluconeogenesis. the data presented in this paper demonstrate that the ketoderivatives rather than the branched chain aminoacids themselves inhibit renal glucosesynthesis from various precursors entering the glucogenic pathway at different levels. though the point of the inhibitory attack of ketoacids could not be localized, an impairement of the kidney cortex to r ... | 1976 | 11967 |
| organ and species differences in microsomal activation of methyldopa. | the covalent binding of 3h-methyldopa to microsomal protein in the presence of nadhp and oxygen was studied in various microsomal preparations. rat and mouse liver microsomes showed high binding, hamster and guinea pig liver microsomes gave intermediate values, whereas no binding was seen with rabbit liver microsomes. no activation of methyldopa was detected with kidney microsomes. lung microsomes from rats, guinea pigs, and rabbits were quite active with respect to methyldopa binding, and the r ... | 1976 | 11971 |
| xenobiotic metabolism and enzyme induction in isolated rat intestinal microsomes. | intestinal microsomes were isolated from rats pretreated with 3-methylcholanthrene (mc), phenobarbital (pb), and pregnenolone-16alpha-carbonitrile (pcn). the metabolism of benzoapyrene (bp), 7-ethoxyresorufin, 7-ethoxycoumarin, and biphenyl were examined. mc induces a 30-fold increase in bp metabolism. with control microsomes, bp metabolism is inhibited by metyrapone, skf 525-a, and antimycin a, but is stimulated 4.5-fold by rotenone. with microsomes from mc-treated rats, bp metabolism is inhibi ... | 1976 | 11972 |
| the rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine. | n-gamma-(2-chlorophenothiazin-10-yl)propylethylenediamine (cl-pped), a common metabolite of prochlorperazine and perphenazine, was orally administered to male rats at a dose of 50 mg/kg, and its concentrations in plasma, liver, lung, kidney, and brain were followed from 6 hr to 40 days after dosage. small quantities were measured by two-dimensional thin-layer chromatography of a fluorescent derivative and in situ fluorometry of the chromatograms. the kinetic behavior of cl-pped in brain differe ... | 1976 | 11973 |
| effect of sex hormones on the disposition in rats of 1-aminocyclohexane carboxylic acid, a metabolite of semisynthetic penicillin. | the renal clearance of 1-aminocyclohexanecarboxylic acid (achc), a metabolite of the semisynthetic penicillin, cyclacillin, is about 10 times faster in female than in male rats. the slower clearance in males is attributed to a higher net rate of reabsorption of the compound from the tubule of the kidney. because achc is not metabolized, it is apparently continuously recirculated through the kidney of the male, resulting in the longer half-life. the sex-related disposition of the metabolite can b ... | 1976 | 11975 |
| species differences in the metabolism and disposition of spironolactone. | the absorption, excretion and metabolism of 22-14cspironolactone was compared in charles river rats, beagle dogs and rhesus monkeys. the drug was administered at the fixed dose of 5 mg/kg po and iv. from the po/iv ratios of the areas under the plasma radioactivity-time curves, the gastrointestinal absorption of the drug was estimated to be 82% in the rat, 62% in the dog, and 103% in the monkey. the absolute bioavailability of a pharmacologically active metabolite, canrenone, was 57% in the dog a ... | 1976 | 11976 |
| identification of basic metabolites of 4-4-(p-chlo- robenzoyl)piperidino-4'-fluorobutyrophenone, an experimental neuroleptic agent. | two metabolites of 4-4-(p-(chlorobenzoyl)piperidino-4'-fluorobutyrophenone (rmi 9901) as well as unchanged drug, have been identified in the urine of rats following oral administration of the drug. analysis of basic urine extracts by combined gas chromatography-mass spectrometry was employed for metabolite identification. n-dealkylation appears to be a major metabolic pathway and results in formation of 4-(p-chlorobenzoyl)piperidine (i). subsequent oxidation of this metabolite results in the for ... | 1976 | 11978 |
| the interaction of flurazepam with diphenylhydantoin in the rat. | | 1976 | 11981 |
| corticotropin releasing factor distribution in normal and brattleboro rat brain, and effect of deafferentation, hypophysectomy and steroid treatment in normal animals. | corticotropin-releasing factor (crf) activity was determined (dispersed pituitary cell assay) in rat median eminence (me), various hypothalamic nuclei, as well as in entire median basal hypothalamus (mbh) and extra-hypothalamic areas. highest concentrations were seen in me, with decreased concentrations noted proceeding dorsally and cephalad from me. potency (niamdd he-rp-1, me reference extract, equivalent to 1.0) estimates were: me-2.2; arcuate n.-0.88; dorsomedial n.-041; ventromedial n.-0.35 ... | 1977 | 11988 |
| pyridine nucleotides in pancreatic islets during inhibition of insulin release by exogenous insulin. | in vitro addition of rat insulin (200, 400 or 800 muu/ml) to collagenase-isolated pancreatic islets of adult rats diminished glucose (3 mg/ml)-induced insulin release which was correlated with a decrease of the ratio of total nadph/nadp and inhibition of glucose oxidation via the pentose phosphate shunt (pps). nadh and nad levels were not affected. it is suggested that exogenous insulin diminishes the islet total nadph/nadp ratio by a direct or indirect decrease in pps activity. however, it is a ... | 1976 | 11990 |
| binding of nuclear triiodothyronine (t3) binding protein-t3 complex to chromatin. | nuclear tirrodothyronine (t3) binding protein (ntbp)-t3 complex, prepared from liver nuclei of rats given 125it3 in vovo, rebinds to rat nuclear chromatin at ph 7.4 and at low, but not high, kcl concentrations. liver ntbp-t3 complex binds to chromatin from liver, kidney, heart, brain, testis, and spleen. binding was depressed at ph8, by addition of 10 mm cacl2 or 100 mm mgcl2, and by 1 mm gtp or utp. although heart chromatin bound the most ntbp-t3 complex and brain the least, there is no clear s ... | 1976 | 11991 |
| teratopsychogenetic effects apparently produced by nonphysiological neurotransmitter concentrations during brain differentiation. | in male rats treated with pargyline, reserpine or pyridostigmine during neonatal life significant permanent changes of sexual behaviour and conditioned learning behaviour were observed in juvenile and/or adult life. male sexual activity and learning capacity were permanently decreased in neonatally pargyline- or reserpine-treated animals, but permanently increased in neonatally pyridostigmine-treated rats. these findings suggest that nonphysiological concentrations and/or turnover rates of neuro ... | 1976 | 11992 |
| effect of propranolol on antinociceptive, tolerance- and dependence-producing properties of morphine in rodents and monkeys. | since an abstinence syndrome may accompany the injection of opioids in addicts pretreated with propranolol the morphine antagonistic properties of this compound were investigated. racemic propranolol did not significantly affect the antinociceptive ed50 of morphine in rodents and neither precipitated abstinence in morphine-dependent monkeys nor exacerbated the syndrome in 24 hr withdrawn monkeys. multiple doses of propranolol did not alter the development of physical dependence on morphine in mo ... | 1975 | 11999 |
| change in the nad-hydrolase activity in the rat myocardium under the influence of antiadrenergic substances. | | 1976 | 12003 |
| stereospecificity of hepatic lipases. | | 1976 | 12007 |
| glutamate transport and the trans-membrane ph gradient in isolated rat-liver mitochondria. | | 1976 | 12011 |
| relationship of the acid micro-climate in rat and human intestine to malabsorption. | | 1976 | 12032 |
| long-range effects of products of carbon tetrachloride-stimulated lipid peroxidation. | | 1976 | 12042 |
| hypolipidaemic agents: current status and recent developments. | | 1976 | 12046 |
| (magnesium plus sodium plus potassium ion)-stimulated adenosine triphosphatase in rat sciatic nerve. | | 1976 | 12056 |
| cathepsin b1 and other lysosomal enzymes in rat ovary during ovulation (author's transl). | | 1976 | 12061 |
| relationships between mucosal hydrolysis and transport of two phenylalanine dipeptides. | in order to investigate the source of free amino acids found in the gut lumen during absorption of dipeptides, as well as evaluating the role of brush border peptidases in the mucosal hydrolysis of dipeptides during absorption, rates of dipeptide disappearance and appearance of hydrolytic products were measured during perfusion of rat jejunum and ileum in vivo with buffered and unbuffered 10 mm solutions of glycl-l-phenylalanine (gly-phe) and l-phenylalanyl-glycine (phe-gly). mucosal brush borde ... | 1976 | 12068 |
| studies on the dynamics and mechanism of glibenclamide-induced insulin secretion. | sustained, 60-minute perfusion of glibenclamide (0.5, 1.5 and 10 mug/ml) elicits a one-phase insulin release profile, formed by a rapid secretion peak followed by a second peak with lower insulin levels than the former. basal insulin secretion values are observed during the period comprised between 13 and 60 minutes of perfusion. concurrent stimulation with glucose (100, 150, 200 and 300 mg%) plus glibenclamide (1 mug/ml) causes a marked rise in both phases of insulin secretion. the addition of ... | 1976 | 12072 |
| effects of d-glyceraldehyde and 3-o-methylglucose upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets. | in perfused pancreatic islets, the fluorescence of reduced pyridine nucleotides was recorded continuously, d-glyceraldehyde (5 mm) or 3-o-methylglucose (27.5 mm) never caused a net fluorescence increase. since stepwise changes of the d-glucose concentration between 0 and 20 mm always induced a fluorescence increase, it is concluded that glucose on the one hand and glyceraldehyde or 3-o-methylglucose on the other hand cause different metabolic states in pancreatic islets. | 1976 | 12074 |
| chemical studies on tobacco smoke. xlii. nitrosonornicotine: presence in tobacco, formation and carcinogenicity. | nnn is the first organic carcinogen isolated from unburned tobacco. it has been found in smoking tobaccos, chewing tobaccos and in snuff in concentrations between 0.3 and 90.0 mug. this appears to be an unusually high concentration for a nitrosamine in an environmental agent. we have presented data which suggest that nnn, and possibly other unknown nitrosamines, are formed during the curing of tobacco and that the nitrate content of tobacco is an important factor in nitrosamine formation. studie ... | 1976 | 12092 |
| ammonia production and excretion in the mammalian kidney. | | 1976 | 12126 |
| involvement of cyclic gmp in the initial stage of hepatocytes proliferation. | a transient rise in cyclic guanosine 3' : 5' monophosphate (c-gmp) in the liver was observed in rats in vivo 10--20 min after partial hepatectomy. a similar increase in c-gmp in the liver was also found in rats in vivo 15 min after infusion of tgh solution (a mixture of triiodothyronine, glucagon, and heparin). in both cases, inductions of ornithine decarboxylase ec 4.1.1.17 and tyrosine aminotransferase ec 2.6.1.5 were found 4 hr after the beginning of the experiments. later, 22 hr after the su ... | 1976 | 12143 |
| studies on triglyceride lipases from rat adipose tissue. | a new assay procedure for triglyceride lipase ec 3.1.1.3 was developed in which radioactive triolein was dissolved in ethanol and directly added to the reaction mixture in the absence of serum and albumin. in the rat adipose tissue there appeared to be a triglyceride lipase measurable with this assay in addition to the two previously defined lipases, lipoprotein lipase ec 3.1.1.34 and hormone-sensitive lipase. the enzyme was active in the absence of serum and was strongly inhibited by albumin. t ... | 1976 | 12145 |
| purification and properties of oxytocinase (cystine amino-peptidase) from monkey placenta. | oxytocinase (cystyl-aminopeptidase) ec 3.4.11.3 was isolated from monkey placenta in a purified form by a six-step prodedure comprising extraction from monkey placenta homogenate, ammonium sulfate fractionation, repeated chromatography on hydroxylapatite, chromatography on a column of deae-cellulose and gel filtration on a column of sephadex g-200. the purified enzyme showed a single band on polyacrylamide disc electrophoresis. oxytocin was inactivated by this enzyme preparation. the enzyme hydr ... | 1976 | 12146 |
| physiological significance of ca uptake by mitochondria in the heart in comparison with that by cardiac sarcoplasmic reticulum. | it was investigated whether mitochondria play a significant role in the physiological regulation of the contractile process by ca2+ in cardiac muscle in comparison with the sarcoplasmic reticulum (sr). ca uptake activities of chicken cardiac sr and rabbit cardiac mitochondria were measured by means of centrifugation, dual-wave-length spectrophotometric and millipore filtration methods. the maximum ca uptake capacity of cardiac sr was usually 50-60 nmoles/mg protein and the apparent binding const ... | 1976 | 12152 |
| activation of soluble guanylate cyclase from rat lung by incubation or by hydrogen peroxide. | a 37,000 x g supernatant fraction prepared from fat lung homogenate demonstrated a 2- to 3-fold increase in guanylate cyclase activity after incubation at 30 degrees for 30 min (preincubation). treatment of the supernatant fraction with triton x-100 increased activity to approximately the same extent as preincubation, but would not increase the activity after preincubation. by chromatography on sepharose 2b, before and after preincubation, it was demonstrated that the increase in activity was on ... | 1976 | 12160 |
| control of phosphofructokinase from rat skeletal muscle. effects of fructose diphosphate, amp, atp, and citrate. | under conditions used previously for demonstrating glycolytic oscillations in muscle extracts (ph 6.65, 0.1 to 0.5 mm atp), phosphofructokinase from rat skeletal muscle is strongly activated by micromolar concentrations of fructose diphosphate. the activation is dependent on the presence of amp. activation by fructose diphosphate and amp, and inhibition by atp, is primarily due to large changes in the apparent affinity of the enzyme for the substrate fructose 6-phosphate. these control propertie ... | 1976 | 12161 |
| solubilized nuclear "receptors" for thyroid hormones. physical characteristics and binding properties, evidence for multiple forms. | tissues regulated by thyroid hormones contain chromatin-localized "receptors" that may be involved in the actions of these hormones. in this report, we describe some properties of these receptors after their solubilization from rat liver nuclei and their separation from nucleic acids and basic proteins. the nuclear extract and partially purified preparations contain a dominant class of binding sites which have a high affinity for triiodothyronine (3,5,3'-triiodo-l-thyronine, kd approximately 1 n ... | 1976 | 12162 |
| evaluation of the h+/site ratio of mitochondrial electron transport from rate measurements. | the mitochondrial h+/site ratio (i.e. the number of protons ejected per pair of electrons traversing each of the energy-conserving sites of the respiratory chain) has been evaluated employing a new experimental approach. in this method the rates of oxygen uptake and h+ ejection were measured simultaneously during the initial period of respiration evoked by addition of succinate to aerobic, rotenone-inhibited, de-energized mitochondria. either k+, in the presence of valinomycin, or ca2+, was used ... | 1976 | 12164 |
| investigation of microsomal oxygenases of biosynthetic processes. stearyl-coa desaturase of adipose tissue and liver. | porcine and rat microsomal stearyl-coa desaturases require reduced pyridine nucleotide and oxygen, are cyanide sensitive, and are insensitive to carbon monoxide. the km for stearyl-coa is somewhat larger for liver than for the adipose desaturases, but, in general, assay conditions are quite similar. adipose tissue microsomes contain cytochromes b5 and p-450, as well as the nadh- and nadph-specific cytochrome reductases. compared to liver, the specific contents and activities of electron carriers ... | 1976 | 12166 |
| appearance of magnesium guanylate cyclase activity in rat liver with sodium azide activation. | native soluble and particulate guanylate cyclase from several rat tissues preferred mn2+ to mg2+ as the sole cation cofactor. wtih 4mm cation, activities with mg2+ were less than 25% of the activities with mn2+. the 1 mm nan3 markedly increased the activity of soluble and particulate preparations from rat liver. wtih nan3 activation guanylate cyclase activities wite similar with mn2+ and mg2+. co2+ was partially effective as a cofactor in the presence of nan3, while ca2+ was a poor cation with o ... | 1976 | 12177 |
| latency of inosine-5'-diphosphatase in microsomes isolated from rat liver. | the latency of inosine-5'-diphosphatase has been studied in microsomes isolated from rat liver. the appearance of latent activity was the result of an increase in the vmax of the enzyme. this was observed when assays were carried out in the presence of sodium deoxycholate, after microsomes were treated wtih phospholipase c, or at ph 10.3 and after microsomes were subjected to nitrogen cavitation. the apparent km of inosine-5'-diphosphatase for idp was unchanged when microsomes were treated with ... | 1976 | 12180 |
| comparison of the size and physical properties of gamma-glutamyltranspeptidase purified from rat kidney following solubilization with papain or with triton x-100. | gamma-glutamyltranspeptidase is associated with the brush border membrane of kidney proximal straight tubule cells. it can be solubilized qualitatively by treatment with papain or triton x-100. neither procedure affects its catalytic activity but the two resulting forms of the enzyme differ considerably in their physical properties. the papain-solubilized transpeptidase is soluble in aqueous buffers and was purified 430-fold. it has an s20,w of 4.9 s, a stokes radius of 36 a, and a calculated mo ... | 1976 | 12182 |
| plasma protein synthesis by isolated rat hepatocytes. | a system of preparation of rat hepatocytes with extended viability has been developed to study the role of hormones and other plasma components upon secretory protein synthesis. hepatocytes maintained in minimal essential medium reduced the levels of all amino acids in the medium except the slowly catabolized amino acids leucine, isoleucine, and valine, which steadily increase as the result of catabolism of liver protein. although the liver cells catabolize 10-15% of their own protein during a 2 ... | 1977 | 12183 |
| adaptive responses of brain cyclic amp-generating systems to alterations in synaptic input. | the concept of subsensitivity and supersensitivity as a mechanism of neuronal adaptation to alterations in synaptic activity in the brain is an attractive one. however, the complexity of the central nervous system has made it difficult to determine the cellular basis of apparent changes in neuronal excitability resulting from alterations in synaptic input (cf. ref. 83). it now seems that, at least for inhibitory central pathways in which cyclic amp-generating systems mediate postsynaptic recepto ... | 1976 | 12192 |
| inhibition of mammalian soluble guanylate cyclase activity by adenosine 5'-tetraphosphate, guanosine 5'-tetraphosphate and other nucleotides. | the effects of a variety of purine and pyrimidine nucleotides were tested for their capacity to inhibit mammalian soluble guanylate cyclase activity. adenosine 5'-tetraphosphate (atetp), atp, adp, amp, guanosine 5'-tetraphosphate (gtetp) and gdp were found to inhibit soluble guanylate cyclase activity from rat lung and other mammalian tissues. the corresponding cytosine and thymine nucleotides showed little or no inhibitory activity, except for thymidine 5'-tetraphosphate, which inhibited glanyl ... | 1976 | 12193 |
| bioorganotin chemistry. metabolism of organotin compounds in microsomal monooxygenase systems and in mammals. | | 1976 | 12202 |
| human epidermal transglutaminase. ii. immunologic properties. | a monospecific antibody for human epidermal transglutaminase was prepared in rabbits. the antibody formed single immunoprecipitin lines with purified or crude human transglutaminases and quantitatively precipitated transglutaminase activity. there were no precipitin reactions between human factor xiii (zymogen or active enzyme) and antihuman epidermal transglutaminase or between human epidermal transglutaminase and antihuman factor xiii. heating epidermal transglutaminase (56 degrees c, 15 min) ... | 1977 | 12234 |
| specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors. | serum or urine from normal adult lewis rats can be shown to contain detectable amounts of idiotypic, antigen-binding receptors with specificity for the major histocompatibility complex locus antigens of the rat, the ag-b locus antigens. such purified naturally occurring receptor molecules, be they of t- or b-lymphocyte origin, can be used in a polymerized form to provoke the production of auto-anti-idiotypic antibodies when injected back into normal lewis rats. as a consequence of this autoimmun ... | 1976 | 12245 |
| steroid sulfatase in brain: comparison of sulfohydrolase activities for various steroid sulfates in normal and pathological brains, including the various forms of metachromatic leukodystrophy. | | 1976 | 12249 |
| the toxic effect of sodium glutamate on rat retina: changes in putative transmitters and their corresponding enzymes. | | 1976 | 12250 |
| properties of rat brain histidine decarboxylase. | | 1976 | 12251 |
| formation of gamma-glutamylhistamine from histamine in rat brain. | | 1976 | 12252 |
| some biological and pharmacological properties of inflammatory exudates. | inflammatory exudates were obtained from polyester sponges which had been implanted subcutaneously in rats four days previously. this material was found to be anti-inflammatory when injected into other rats in which carrageenan pleurisy had been induced. at a dose of 600 mg kg-1 exudate inhibited the formation of pleural effusion, emigration of both neutrophils and mononuclear cells and the accumulation of beta-glucuronidase and lactic dehydrogenase. the same dose of sponge exudate did not howev ... | 1976 | 12258 |
| the role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs. | the ability of several non-steroidal acidic anti-inflammatory drugs to cause ulceration when given as copper complexes has been examined. the damage caused by clopirac, niflumic acid and aspirin was virtually abolished when they were given as copper complexes whereas the damage caused by indomethacin, ketoprofen and (+)-naproxen was unaltered. the lack of ulceration with three of these preparations appeared to be correlated with a much reduced ability to inhibit prostaglandin synthesis as determ ... | 1976 | 12259 |
| anabolic and androgenic activities, in rat, of some nandrolone and androstanolone esters. | the anabolic and androgenic activities of the formate to undecanoate esters of nandrolone and formate to valerate esters of androstanolone, after intramuscular injection, have been determined in rat. the response to a given dose was measured as cumulative weight (the area under the plot of weight of indicator organ against time). levator anus muscle was used to assess anabolic activity, and the sum of the cumulative weight for prostate and seminal vesicles for androgenic activity. log dose-log c ... | 1976 | 12263 |
| 6,8-di-t-butyl-4-oxo-4h-1-benzopyran-2-carboxylic acid: a chromone derivative with anti-allergic, anti-inflammatory and uricosuric activity. | | 1976 | 12270 |
| the effect of indomethacin on carrageenan pleurisy in inbred strains of rats. | | 1976 | 12271 |
| effect of trazodone on brain dopamine metabolism. | | 1976 | 12273 |
| the acetylating enzymes of rat brain homogenates proceedings. | | 1976 | 12285 |
| chemical oxidation and in vitro metabolism of 1-(4-chlorophenylazo) piperidine and its heteroalicyclic analogues proceeding. | | 1976 | 12290 |
| an in vitro model of drug-metal ion interactions in the gut proceedings. | | 1976 | 12308 |
| the interaction between clonidine and desmethylimipramine: effects on blood pressure and central catecholamine metabolism proceedings. | | 1976 | 12309 |
| interaction between amphetamine and progesterone: effects on noradrenaline metabolism in discrete areas of rat brain proceedings. | | 1976 | 12310 |
| changes in the conditiond avoidance behaviour of rats following the administration of drugs to the amygdala proceedings. | | 1976 | 12311 |
| monoamine concentrations in eight areas of the brains of mature and immature male rats and effects of injected hormones proceedings. | | 1976 | 12312 |
| absorption, elimination and duration of action of diethyldithiocarbamate in animals proceedings. | | 1976 | 12313 |
| effect of alloxan diabetes on the sensitivity of the rat diaphragm to drugs proceedings. | | 1976 | 12357 |
| antinociceptive and sympathomimetic activities of exo-andendo-2-aminobenzonorbornene and their n-methylated derivatives proceedings. | | 1976 | 12360 |
| org 6216: a novel type of anti-inflammatory steroid proceedings. | | 1976 | 12362 |
| guanylate cyclase activity in fetal, neonatal and adult rat heart. | | 1976 | 12374 |
| failure to prove arenavirus infection among the small mammals from an endemic area of korean hemorrhagic nephrosonephritis. | in the light of recent knowledge on a complex of diseases caused by a new group of viruses, arenaviruses, virological studies largely directed toward small field mammals were undertaken during 1973-1974 aiming at etiological clarification of korean hemorrhagic nephrosonephritis (khnn). specimens were collected in an endemic area of khnn located north to northeast of seoul. virus isolation tests with 299 urine specimens and 131 mite pools recovered from small mammals and 14 acute stage sera from ... | 1976 | 12383 |
| effects of l-glutamine of acetylsalicylic acid or taurocholic acid-induced gastric lesions and secretory changes in pylorus-ligated rats under normal or stress conditions. | an oral dosing of either acetylsalicylic acid (asa) or taurocholic acid (tca) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric musoca in contrast to the irritation observed in non-stressed ones. the irritative activity of asa or tca on gastric mucosa under stress was dose-dependent. stress itself (23 degrees c, 7 hr) did not induce any appreciable changes in gastric mucosa under stress wasic mucosa of rats. l-glutamine, given together with sas or ... | 1976 | 12388 |
| studies on monoamine oxidase. xviii. enzymic properties of placental monoamine oxidase. | enzymic properties of partially purified monoamine oxidase (mao) from human placenta were studied with tyramine, serotonin and benzylamine as substrates. the highest activity was obtained with serotonin and almost no activity was observed with benzylamine. these results are similar to those obtained with rat placental mao, but different from those with rabbit placental mao. the km values for serotonin and tyramine were found to be 0.21 mm and 0.23 mm, respectively and the ph optimum was 8.1 with ... | 1976 | 12389 |
| pharmacological studies on triazine derivatives v sedative and neuroleptic actions of 2-amino-4-4-(2-hydroxyethyl)-piperazin-1-yl-6-trifluoromethyl-s-triazine (tr-10). | pharmacological properties of 2 amino-4-4-(2-hydroxyethyl)-piperazin-1-yl-6-trifluoromethyl-s-triazine (tr-10) were investigated in mice and rats. chlorpromazine served as a reference compound. tr-10 expressed in general the pharmacological profiles as neuroleptic ascertained by anti-methamphetamine activity, supression of conditioned avoidance response, taming effects, decrease in exploratory behavior and cataleptogenic activity. among these effects, anti-methamphetamine action was most potent. ... | 1976 | 12393 |
| effects of narcotic analgesics on serotonin metabolism in brain of rats and mice. | the effects of narcotic analgesics on the brain 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels of rats and mice were investigated in relation to our preceding data on the effect of humoral modulatorents. the results suggest that morphine accelerates the release of brain 5-ht both in rats and mice, and that neither methadone nor pethidine alters the brain 5-ht and 5-hiaa levels in rats. the morphine-induced increase in brain 5-ht turnover is likely to be involved in the ... | 1976 | 12394 |
| selective alpha-adrenoceptor blocking actions of a new derivative of 2-halogenotheylamine: 6-(2-bromoethyl)-10,11-methylenedioxy-5,6,7,8-tetrahydrodibenzc,eazocine. | a new compound, 6-(2-bromoethyl)-10,11-methylenedioxy-5,6,7,8-tetrahydrodibenz c,e azocine (da-viii-mbr) was found to have a more selective alpha-adrenergic blocking action than dibenamine or phenoxybenzamine. from dose-response curves for adrenaline and 5-hydroxytryptamine (5-ht) obtained in strips of rat aorta before and after incubation with each of the three blocking agents, the fractions of receptors remaining active for adrenaline and 5-ht, respectively, were estimated. after blockade with ... | 1976 | 12395 |
| immunohistochemical studies on the localization and distribution of monoamine neuron systems in the rat brain. i. tyrosine hydroxylase in the mes- and diencephalon. | the localization and distribution of tyrosine hydroxylase (th), the first enzyme in the catecholamine synthesis, in the mes- and diencephalon has been studied with the indirect immunofluorescence technique of coons and collaborators. principally, th was present in neuron systems with a distribution similar to known dopamine, noradrenaline and adrenaline systems. the present data, taken together with published and some unpublished results, indicate that all parts of most central dopamine neurons, ... | 1976 | 12423 |
| neurochemical changes following the administration of depleters of biogenic monoamines. | | 1976 | 12434 |
| cretinism: influence on rate-limiting enzymes of amine synthesis in rat brain. | | 1976 | 12435 |
| effects of hypophysectomy, adrenalectomy and corticosterone treatment on uptake and release of putative central neurotransmitters by rat hypothalamic tissue in vitro. | | 1976 | 12436 |
| a lysosomal factor that interconverts multiple forms of rat liver tyrosine aminotransferase. | | 1976 | 12437 |
| regional and subcellular distributions of brain neurotensin. | | 1976 | 12438 |
| comparison of catechol-q-methyltransferase from rat brain, erythrocytes and liver. | | 1976 | 12439 |
| dihydroergotamine binding to rat brain membranes. | | 1976 | 12440 |
| dopaminergic neurons: effects of electrical stimulation on tyrosine hydroxylase. | | 1976 | 12461 |
| opiate receptors in the brain. | | 1977 | 12470 |
| relationship between reward-enhancing and stereotypical effects of psychomotor stimulant drugs. | | 1976 | 12471 |
| release and metabolism of substance p in rat hypothalamus. | | 1976 | 12473 |
| release of substance p-like immunoreactivity from isolated spinal cord of newborn rat. | | 1976 | 12474 |
| the effects of antipsychotics on the turnover rate of gaba and acetylcholine in rat brain nuclei. | | 1976 | 12475 |
| interaction of benzodiazepines with neuroleptics at central dopamine neurons. | several benzodiazepines (chlordiazepoxide, clonazepam, diazepam and flunitrazepam) markedly counteracted the elevation of the homovanillic acid (hva) content of the rat brain induced by neuroleptics (haloperidol, pimozide, chlorpromazine, and clozapine). a similar effect was obtained with the inhibitor of gaba transaminase, aminooxyacetic acid (aoaa). the interaction of benzodiazepines with the neuroleptic-induced hva increase was similar in the striatum and in the limbic forebrain and was antag ... | 1976 | 12477 |
| effects of enzyme induction and inhibition on microsomal oxidation of 1,4-benzodiazepines. | metabolic oxidative profiles of diazepam (i) were obtained by aromatic c-4'-hydroxylation, n-1-demethylation, and 3-hydroxylation using a supernatant of rat liver. incubation of 3-methyldiazepam (vi), which suppressed 3-hydroxylation, and n-1-nor-3-methyldiazepam (vii), were used to separately investigate these three oxidative pathways. treatment of animals with phenobarbital enhanced n-1-demethylation and 3-hydroxylation, and to a variable extent c-4'-hydroxylation. application of metyrapone re ... | 1976 | 12479 |
| dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigro-neostriatal pathway. | in vivo studies demonstrate that administration of gamma-butyrolactone, a precursor of gamma-hydroxybutyric acid causes a rapid increase in endogenous levels of striatal dopamine and an increase in tyrosine hydroxylase activity measured by following the short term accumulation of dihydroxyphenylalanine. the increase in dopamine produced by gbl is blocked by stimulation of the nigro-neostriatal pathway. if dopamine is allowed to accumulate for 30 min following administration of gbl this increased ... | 1976 | 12482 |