| biological activity of pityrosporum. i. enhancement of resistance in mice stimulated by pityrosporum against salmonella typhimurium. | the effect of administration with pityrosporum (p. orbiculare, p. ovale, p. pachydermatis and pityrosporum sp.) on susceptibility of mice to salmonella typhimurium infection was studied. pretreatment of mice with 50 mg (wet weight) of killed pityrosporum 4 days prior to the intraperitoneal (i.p.) challenge of 4 x 10(5) (10 ld50) s. typhimurium elicited resistance comparable to that induced by 500 micrograms (dry weight) of killed propionibacterium acnes and over 30% of the infected mice survived ... | 1984 | 6368372 |
| combination chemotherapy (vac/fmc) with immunostimulation in metastatic breast cancer: a randomized study comparing different times and routes of administration of corynebacterium parvum. | from january 1978 to december 1980, 222 patients with metastatic breast cancer were included into a prospective multicenter trial. all patients were treated once a month with six cycles of vac- (vincristine, adriamycin, cyclophosphamide) chemotherapy, followed by fmc (5-fluorouracil, methotrexate, cyclophosphamide) until progression was documented. by random assignment, the patients received immunostimulation with corynebacterium parvum (cp) by one of four methods: subcutaneous (sc) on either da ... | 1984 | 6368960 |
| ineffectiveness of adjuvant chemotherapy using dtic and cyclophosphamide in patients with resectable metastatic melanoma. | a randomized, prospective trial of adjuvant chemoimmunotherapy was compared in a group of 136 patients with melanoma after complete surgical resection of advanced regional metastasis (stage iii) or isolated distant metastasis (stage iv). all patients received a 2-year course of nonspecific adjuvant immunotherapy of subcutaneous injections of corynebacterium parvum (4 mg/m2 divided among the four extremities in 1- to 2-week cycles). half of the patients also received a 6-month course of dimethyl ... | 1984 | 6369594 |
| controlled study with imidazole carboxamide (dtic), dtic + bacillus calmette-guérin (bcg), and dtic + corynebacterium parvum in advanced malignant melanoma. w.h.o. collaborating centres for evaluation of methods of diagnosis and treatment of melanoma. | from 1976 to 1980, 377 randomized patients were entered in a multicentric study supported by the w.h.o. melanoma group. in this report, only 196 patients are considered for analysis: 31.6% were excluded because of inadequate treatment or protocol violations. three arms of treatment were compared: dtic alone, dtic plus bacillus calmette-guérin, and dtic plus corynebacterium parvum. no significant difference in terms of complete response plus partial response was detected among the three regimens. ... | 1984 | 6369694 |
| bactericidal activity of wet cerumen. | the viable populations of seven species of bacteria were reduced 17% to 99% by treatment with a 3% suspension of human cerumen of the soft or "wet" type. species tested for susceptibility to cerumen were staphylococcus aureus, staphlylococcus epidermidis, streptococcus pyogenes, propionibacterium acnes, corynebacterium spp, escherichia coli, and serratia marcescens. the reduction depended upon the species of bacterium and the age of the culture. pathogenic species appeared to be more susceptible ... | 1984 | 6370076 |
| a longitudinal study of actinomyces israelii in the female genital tract. | a prospective longitudinal investigation was performed to study variations in the occurrence of actinomyces israelii with reference to four microorganisms, staphylococci, e. coli, p. acnes and c. albicans, in the female genital tract. fifteen healthy women were studied during all phases of the menstrual cycle. sampling was made from the cervix, vagina and perineal area three times a week during two consecutive menstrual periods and during menstruation from napkins and tampons. altogether 1108 sa ... | 1984 | 6375245 |
| [mechanisms of production of tumor necrosis factor (tnf)--reconstitution experiment white nude mice]. | in order to investigate the role of t cells in the production of tumor necrosis factor (tnf), a reconstitution experiment was performed with nude mice (balb/c, nu/nu). the results obtained were as follows: the cytotoxic activity of tumor necrosis serum (tns) from balb/c, nu/nu mice treated with p. acnes-lps was 1/22 against that from balb/c, nu/+ mice. tnf activity increased 14 times in reconstituted nude mice against balb/c, nu/nu mice. investigation of the production of the cytotoxic activity ... | 1984 | 6375575 |
| [postoperative immunostimulation in non-small-cell bronchial carcinoma. outcome and complications]. | in two prospective, randomized clinical studies corynebacterium parvum (c.p.), bcg or 0.9% saline solution were injected intrapleurally once between the 6th and 12th postoperative day in 878 patients with resected, non-oatcell bronchial carcinoma (stage i and ii). the rate of complications following c.p.-instillation (chest pain, fever) was relatively low compared to partially serious complications following injection of bcg, especially in patients who underwent pneumonectomy (21.8% empyema comp ... | 1984 | 6376041 |
| frequent isolation of propionibacterium acnes from sarcoidosis lymph nodes. | isolation of propionibacterium acnes from biopsied lymph nodes of sarcoidosis patients and from the lymph nodes or other tissues of non-sarcoidosis patients was carried out, carefully avoiding contamination by skin-resident p. acnes. out of 40 sarcoidosis lymph nodes examined, 31 nodes (77.5%) showed a positive culture of p. acnes, while 38 of 180 (21.1%) non-sarcoidosis tissues revealed positive results, the difference being significant (p less than 0.001). among non-sarcoidosis tissues, the in ... | 1984 | 6377763 |
| immunomodulators in the treatment of peritonitis in burned and malnourished animals. | deficiencies in the immune system that lead to increased morbidity and mortality from infectious complications have been well documented in patients suffering from trauma, malnutrition, sepsis, and thermal injuries. we investigated the potential benefit of immune stimulation for preventing infection in such conditions in an animal model by evaluating three drugs: corynebacterium parvum, thymopentin (tp-5), and cp-46,665. one-hundred eighty female guinea pigs were rendered immunodeficient by firs ... | 1984 | 6379960 |
| role of natural killer cells in host defense against cancer metastasis. | | 1983 | 6382510 |
| differences in tumour necrosis factor productive ability among rodents. | large differences in tumour necrosis factor (tnf) productive ability 05337257erved among various strains of mice. ddy, cd-1, icr and dba/2 mice could produce a high titre of tnf activity, whereas balb/c, c3h/hejms and a/j mice produced a low titre of tnf activity. administration of 200 micrograms/mouse of lps to some strains of mice, i.e. ddd and c57b1/6j resulted in good production of tnf. icr nu/nu mice produced the highest tnf activity among the nude mice. balb/c nu/nu and ddd nu/nu mice exhi ... | 1984 | 6386027 |
| immunosuppressive activities of peritoneal and splenic macrophages in murine leprosy: effect on lymphocyte transformation and tumor growth. | the ability of peritoneal macrophages (pm) and splenic macrophages (sm) to suppress tumor growth and lymphocyte transformation in vitro was studied in infected mice with mycobacterium lepraemurium (mlm). both pm and sm of leprous mice showed cytostatic activity against tumor cells in vitro. however, such cells showed significantly less cytostatic activity on a per cell basis than highly activated macrophages obtained from corynebacterium parvum-immunized mice. furthermore, this cytostatic activi ... | 1984 | 6387401 |
| isolation of obligate anaerobic bacteria from bovine abscesses in sites other than the liver. | a survey in japan showed that of 2036 slaughtered cattle 58(3%) had abscesses in sites other than the liver. in 21 of the affected animals the lesions were pulmonary and in 32 abdominal (excluding hepatic); in five animals the lesions were found elsewhere (muscle 2, skin 2, bone 1). nineteen (33%) of the 58 cattle also had abscesses in the liver. obligate anaerobes alone were isolated from 17(29%) of the affected animals (fusobacterium necrophorum 14, bacteroides spp. 2, peptostreptococcus anaer ... | 1984 | 6389873 |
| treatment of inoperable non-small cell carcinoma of the lung with radiation therapy, with or without levamisole. a randomized trial of the southeastern cancer study group. | in a randomized trial, 251 patients with inoperable non-small cell lung cancer received radiation therapy (rt) with or without levamisole (2.5 mg/kg twice weekly for 1 year, or until progression). radiation therapy was delivered to 6000-6500 rad for stages i and ii, and 4000-4500 rad by continuous or split course for stage iii disease. responses were observed in 40% of patients receiving placebo, and in 29% of patients taking levamisole. relapse occurred at local sites only in 53% of the placebo ... | 1984 | 6391141 |
| role of first stimulating agents in the production of tumor necrosis factor. | the conditions and kinetics of tumor necrosis factor (tnf) production were examined. for tnf production, dual stimulation is necessary. priming agents such as bcg, corynebacterium parvum, and zymosan, which can stimulate the reticuloendothelial system (res), are good substances for tnf production with the aid of lipopolysaccharide. wide differences are observed in tnf producibility among different priming agents. the producibility of tnf depends on the degree of stimulation of the res by the pri ... | 1984 | 6391657 |
| [clinical trials of immunotherapy in lung cancer]. | | 1984 | 6393588 |
| [corynebacteria--stimulators of antitumor resistance]. | the results of clinical and experimental studies with corynebacteria stimulation of antitumour resistance are described. it is shown that antitumour effect depends on the mode, dose and period of corynebacteria administration as well as on the stage of the tumour process. the mode of corynebacteria action is under discussion. there are doubts as to expediency of such a method of nonspecific immunotherapy of malignant tumours. | 1984 | 6396064 |
| radiosensitivity of c. parvum-stimulated spleen to acute 60co and low dose rate 137cs and 252cf irradiation. | stimulation of spleen growth by injection of c. parvum led to rapid organ enlargement, and acute 60co or low dose rate (ldr) 137cs or 252cf irradiation reduced the maximum enlargement achieved. irradiations were carried out 3 days after cp injection. sigmoid dose-response curves were observed for the fraction of maximum enlargement achieved after acute 60co. after low dose rate 137cs or 252cf irradiation, exponential dose-response curves of very different slope were observed. acute and ldr gamma ... | 1984 | 6396264 |
| propionibacterium, corynebacterium, mycobacterium and lepra bacilli. | evidence is presented which suggests that certain key markers of lepra bacilli reside collectively in proprionibacterium acnes, corynebacterium tuberculostearicum and mycobacterium leprae. the unrestricted replication of mycobacterium leprae depends most probably upon the presence of an immune-deficiency-inducing viral agent or possibly on the combined effects of the organisms considered. | 1984 | 6398580 |
| studies of the extracellular proteolytic activity produced by propionibacterium acnes. | of several commercial media tested, trypticase soya both containing 0.4% (w/v) d-sorbitol was superior as a growth medium for the production of extracellular proteinase by propionibacterium acnes (strain p-37). extracellular proteinase, production of which was shown to be growth-associated by both batch and continuous culture studies, was partially purified by 70% (nh4)2so4 saturation. sephadex g-75 chromatography and ion exchange on deae-sephadex a-50. it was shown to be a heterogeneous mixture ... | 1983 | 6406421 |
| an evaluation of the antifungal effect of bifonazole on torulopsis glabrata and candida albicans under various in vitro test conditions. | 1-[(4-biphenylyl)-phenylmethyl]-1h-imidazole (bifonazole, bay h 4502, mycospor) showed in vitro significant inhibitory activity against torulopsis glabrata, candida albicans, pityrosporum ovale, corynebacterium acnes and staphylococcus epidermidis. the antifungal activity of bifonazole against t. glabrata and c. albicans varied with the in vitro test conditions. there was a tendency for minimal inhibitory concentrations to increase as fungal inoculum size was increased and as incubation time was ... | 1983 | 6409128 |
| kinetics of killing listeria monocytogenes by macrophages: rapid killing accompanying phagocytosis. | the kinetics of bactericidal activity of activated macrophages can be precisely described by a mathematical model in which phagocytosis, killing, digestion, and release of degraded bacterial material are considered to occur continuously. to gain a better understanding of these events, i have determined the period of time between first contact of bacteria with macrophages and the onset of killing. activated rat peritoneal macrophages were incubated for various times up to 15 min with listeria mon ... | 1983 | 6411918 |
| adjuvant immune stimulation with corynebacterium parvum during maintenance chemotherapy of acute myeloid leukemia. a prospective randomized study. | of 93 consecutively treated patients with acute myeloid leukemia 36 (39%) achieved complete remission (cr). thirty-five patients were randomized to receive either maintenance chemotherapy alone (c) or a combination of active nonspecific immunotherapy with corynebacterium parvum and chemotherapy (c + i). maintenance therapy was given monthly for 1 year or until relapse. the median survival time was 21 months for patients treated with chemotherapy alone, compared with 30 months for patients treate ... | 1983 | 6420046 |
| oxygen radical production by peritoneal macrophages and kupffer cells elicited with lactobacillus casei. | balb/c mice were injected intraperitoneally (i.p.) or intravenously (i.v.) with lactobacillus casei yit9018 (lc 9018). the i.p. injected lc 9018 augmented oxygen radical (or) production by peritoneal macrophages (pm) and suppressed the production of prostaglandin e2 by pm. the growth of i.p. inoculated meth a fibrosarcoma was also inhibited by an i.p. injection of lc 9018. i.v. injection of lc 9018 stimulated or production by fixed macrophages and inhibited the growth of listeria monocytogenes i ... | 1984 | 6423544 |
| adoptive immunization against an established tumor with cytolytic versus memory t cells. immediate versus delayed onset of regression. | intradermal injection of an admixture of p815 tumor cells and corynebacterium parvum results in the emergence of a tumor that grows progressively for 9-10 days and then undergoes complete regression. tumor regression is preceded by a cytolytic t cell response in the spleen that peaks on day 10 and then undergoes progressive decay until days 15-16 when cytolytic t cells can no longer be detected. passive transfer of 10-day or 30-day spleen cells to t-cell-deficient recipients bearing a 4-day tumo ... | 1984 | 6427998 |
| adjuvant requirements for protective immunization of mice using a trypanosoma cruzi 90k cell surface glycoprotein. | a wide range of adjuvants including alhydrogel, saponin, corynebacterium parvum, ddab, pfizer cp-20,961, oil adjuvants and several mdp analogues have been compared for their adjuvant activity in protecting mice against lethal trypanosoma cruzi infection following immunization with a t. cruzi 90k cell surface glycoprotein. only saponin was found to be effective. promotion did not correlate with the ability to promote a particular ig isotype; however, saponin was unique in its ability to promote c ... | 1984 | 6429057 |
| [isolation of propionibacterium acnes and enterobacter cloacae from a case of infective endocarditis]. | | 1984 | 6431026 |
| diffuse sclerosing osteomyelitis of the mandible. | the medical care of patients with diffuse sclerosing osteomyelitis (dso) of the mandible has been unsatisfactory. the main reasons for this have been insufficient knowledge of the disease and its natural history, difficulties in establishing the correct diagnosis, and the unknown etiology. the clinical features and natural history of the disease were studied by means of repeated radiographic and scintigraphic recordings. the biopsy technique was improved by using a slowly rotating coarse trepan ... | 1984 | 6437998 |
| comparison of antitumor activity of lactobacillus casei with other bacterial immunopotentiators. | antitumor activity of lactobacillus casei yit 9018 (lc9018) was demonstrated by intralesional (i.l.) or intravenous (i.v.) administration into tumor-bearing mice which were inoculated with methylcholanthrene-induced fibrosarcoma (meth a) or kirsten murine sarcoma virus-transformed tumor (k234) cells. its activity was significantly superior to the activity of two other species of lactobacilli but was nearly the same as that of corynebacterium parvum or mycobacterium bovis bacille calmette-guérin ... | 1984 | 6438456 |
| [experimental studies on the treatment and prophylaxis of cancer by immunoactivators and interferon]. | | 1984 | 6440934 |
| cytotaxin production by comedonal bacteria (propionibacterium acnes, propionibacterium granulosum and staphylococcus epidermidis). | the potential role of different species of comedonal bacteria as chemotactic stimuli in the inflammatory phase of acne vulgaris was investigated by comparing 12 strains of staphylococcus epidermidis, 11 strains of propionibacterium acnes, and 5 strains of p. granulosum for production of cytotaxin in vitro. results indicated that not only were there marked differences in cytotaxin production between different strains of the same species grown under identical growth conditons, but there were often ... | 1980 | 6444322 |
| immune-complex glomerulonephritis secondary to nonspecific immunotherapy. | hematuria and renal failure developed in two patients with metastatic breast carcinoma while they were receiving nonspecific immunotherapy and chemotherapy. the electron microscopy picture was suggestive of immune-complex glomerulonephritis. | 1980 | 6444365 |
| acne vulgaris: is the bacterial population size significant? | the levels of propionibacterium acnes (p. acnes) and members of the micrococcaceae were enumerated in two separate studies. the first investigation on the foreheads of thirty-five mild and thirty-five moderate acne patients showed no significant difference in the bacterial populations of the two groups. the second investigation of twelve patients on 250 mg tetracycline twice daily for 3 months showed no significant difference compared to pre-treatment data in the bacterial population during the ... | 1980 | 6445202 |
| polymorphonuclear leukocyte lysosomal release in response to propionibacterium acnes in vitro and its enhancement by sera from inflammatory acne patients. | propionibacterium acnes cells were tested for the ability to trigger lysosomal hydrolase release from human polymorphonuclear leukocytes. representative strains of p. acnes serotype i and ii failed to stimulate lysosomal release in the absence of serum. p. acnes growth culture supernatants failed to trigger release under any test condition. addition of fresh or heat-inactivated human serum resulted in lysosomal hydrolase release directly proportional to the number of p. acnes/pmn. pooled sera fr ... | 1980 | 6445921 |
| in vitro effects of skin lipid extracts on skin bacteria in relation to age and acne changes. | skin lipid extracts of 185 persons of different age were tested in vitro against single representatives of skin bacteria: staphylococcus aureus, s. epidermidis, propionibacterium acnes, p. granulosum and corynebacterium sp. in order to find differences in their inhibitory effects. percentages of the extracts inhibiting the first 4 bacteria were nearly the same (about 20%) while corynebacteria were inhibited by only 3 extracts. extracts showing these properties were isolated mainly from adolescen ... | 1980 | 6445923 |
| [inhibition of propionibacteria in the sebaceous gland duct using photochemotherapy and 8-methoxypsoralen]. | it was shown by in vitro studies that 8-methoxypsoralen (= 8 mop) alone and uva irradiation alone produces relatively little inhibition of the growth of propionibacterium acnes and propionibacterium granulosum, whereas a combination leads to an intense suppression of bacterial growth. it was further demonstrated by in vivo studies on 14 subjects that local treatment with 8 mop and uva significantly reduces the propionibacteria in the pilosebaceous duct. these results afford a possible explanatio ... | 1980 | 6446813 |
| [antibacterial effect of an erythromycin-containing topical preparation on the auxanogram test]. | | 1980 | 6447418 |
| the treatment of acne. | | 1980 | 6447680 |
| penetration of topical clindamycin into comedones. | comedones were removed from patients on topical clindamycin and assayed for that antibiotic by of two methods. prominent levels were found in eight of ten patients by one bioassay method. once whole comedones from a patient were found to be positive, other comedones were microdissected to separate the external and internal portions. prominent levels of clindamycin were found in the inner portion as early as 2 weeks. further, the antibiotic could always be found in the internal portion when it wa ... | 1980 | 6447714 |
| topical clindamycin treatment of acne. clinical, surface lipid composition, and quantitative surface microbiology response. | a double-blind study has been conducted to examine the effect of topical 1% clindamycin hydrochloride hydrate in a hydroalcoholic vehicle as compared to the effect of the vehicle alone. fourteen patients applied clindamycin or vehicle alone twice daily for eight weeks. free fatty acid surface lipid percentages, quantitative bacterial counts, and clinical response were assessed every two weeks. a significant reduction (88%) in the percentage of free fatty acids in the surface lipids was seen in t ... | 1980 | 6448025 |
| immune-complex disease in mice and humans given c. parvum. | the present studies in mice and cancer-bearing patients, treated with c. parvum (cp) immunotherapy, were to determine the effects of cp on the production of immune complexes (ic) and associated disease. using the clq-binding assay, circulating immune complexes were detected in mice given a single high dose of cp (466 microgram) and repeated human-equivalent doses (70 microgram). all mice treated with cp developed proliferative glomerulonephritis, the severity of which was dose-related. the histo ... | 1980 | 6448615 |
| acne vulgaris: pathogenesis and treatment. | | 1980 | 6448651 |
| non-specific inhibitory processes of immunological and mitogenic cellular responses. | the suppressive effects of four agents on several types of in vitro immune response and on in vitro responses to t and b mitogens were studied comparatively in spleen cells from c57b1/6 mice, previously injected with each of these agents. it was found that the in vitro pfc response to sheep erythrocytes was the most constantly and extensively inhibited: from 56% after treatment with con a to 85% after treatment with hsa; lps and c. parvum also provoked a strong inhibition (74-78%). inhibition of ... | 1980 | 6448806 |
| isolation, purification, and properties of neuraminidase from propionibacterium acnes. | neuraminidase activity was discovered in 32 of 38 strains of propionibacterium acnes. enzyme production was studied in yeast extract bouillon of different ph containing various amounts of human milk as neuraminidase inductor. enzyme activity was found in the bacterial sediments as well as in the culture filtrates. since neither ultrasonic treatment nor lysozyme incubation of bacterial sediments did release reasonable amounts of enzyme, culture filtrates were used for enzyme preparation. neuramin ... | 1980 | 6449120 |
| taxonomy and clinical significance of actinomycetaceae and propionibacteriaceae. | in spite of considerable advances during the last years, classification and identification of actinomycetaceae and propionibacteriaceae still present major problems. uncertainties about the systematic position and taxonomic status of several genera and species, the lack of reliable distinguishing characteristics or use of inadequately adapted techniques of investigation interfere with both micribiological and clinical research and also with routine work in the diagnostic laboratory. nevertheless ... | 1980 | 6450169 |
| delayed skin test reactivity to propionibacterium acnes correlates with severity of inflammation in acne vulgaris. | propionibacterium acnes is the bacterial species most consistently isolated from acne lesions. intradermal injection of a heat-killed suspension of p. acnes induced a delayed erythematous and often popular inflammatory reaction which was maximal after 24-48 h. this response was dose related and was probably mediated at least partly by immune mechanisms. in eighty-one subjects with acne of varying severity of the acne. these findings indicate that the host response to p. acnes is an important var ... | 1980 | 6450605 |
| p. acnes and the chemistry of sebum. | | 1980 | 6451123 |
| use of systemic antibiotics in acne. | | 1980 | 6451129 |
| topical antibiotics and topical antimicrobial agents in acne therapy. | | 1980 | 6451130 |
| general considerations by a clinical bacteriologist regarding antibiotic therapy in acne. | | 1980 | 6451131 |
| experience gained in immunotherapy from the immunopharmacology of bcg leading to a second generation of systemic immunity adjuvants. | | 1980 | 6451350 |
| in vitro augmentation of rat natural killer (nk) cell activity. | in vitro augmentation of rat natural killer (nk) cell activity was produced by 2 types of treatment. increased activity occurred "spontaneously" when spleen cells were cultured alone at 37 degrees c. this augmentation was dependent on the presence of adherent, phagocytic cells, presumably macrophages, and was independent of lps of fcs. normally low levels of nk activity, present in macrophage-depleted cultured cells, could also be boosted in vitro by incubation with corynebacterium parvum. this ... | 1981 | 6451648 |
| proliferative glomerulonephritis in mice given intravenous corynebacterium parvum. | mice given a killed suspension of corynebacterium parvum (c.p.) developed nephritis as part of an immune complex disease. the nephritis was dose-related. after a single dose of 70 microgram (a human-equivalent dose) or of 466 microgram there was a mesangiopathic glomerulonephritis and after repeated human-equivalent doses there was a mesangiocapillary glomerulonephritis. antibodies to c.p. increased and circulating immune complexes were detected. mice receiving repeated doses also developed an a ... | 1981 | 6451676 |
| suppressor t cells and suppressor macrophages induced by corynebacterium parvum. | | 1981 | 6452218 |
| [on the propionibacteria in the pilosebaceous ducts of uninvolved skin of acne patients. investigations on juvenile acne patients with predominant comedones and healthy controls (author's transl)]. | | 1980 | 6452296 |
| topical erythromycin for acne vulgaris. | the clinical response of topical erythromycin (1%) in a new penetrative vehicle was evaluated in a double-blind investigation on 28 patients with severe and moderate acne vulgaris. the verum preparation was superior to the placebo in 21 of the patients, while in 4 the reverse was true and in 3 no differences were seen. it is thus obvious that topical erythromycin in the penetrative vehicle is a potent agent for acne treatment. the risk for development of resistant propionibacterium acnes strains ... | 1980 | 6452297 |
| contribution to the interpretation of the occurrence of unsuccessful therapeutical results in acne vulgaris with topical erythromycin (propionibact. acnes). | investigations are reported which attempt to contribute towards an understanding of those cases in which topical treatment with erythromycin is unsuccessful. in 13 acne patients no resistance of p. acnes was observed after seven weeks of topical treatment with erythromycin. this demonstrates that the 20% frequency of resistance induction reported in the literature is too high. in the 13 treated patients there was no essential reduction in the number of inflammatory lesions although a decrease in ... | 1981 | 6452774 |
| is acne a bacterial disease? | | 1981 | 6453166 |
| modulation of suppressor mechanisms in allergic contact dermatitis: 2. inhibition of suppressor t-lymphocytes by corynebacterium parvum. | pretreatment of balb/c mice with corynebacterium parvum inhibited the induction of tolerance to the contact sensitizing agent 2,4-dinitrofluorobenzene induced by intravenous injection of dnbso3. the suppressive effect on tolerance induction has further been analyzed by adoptive transfer experiments. injection of c. parvum intraperitoneally (0.7-2.8 mg/mouse) before injection of the tolergen inhibited the generation of t-suppressor cells as shown by transfer of spleen cells from the tolerized don ... | 1981 | 6453168 |
| antibodies against extractable components from propionibacterium acnes in humans with and without acne vulgaris. | acidic polysaccharides (ap) are released from propionibacterium acnes i and ii during growth. similar antigens are released from two strains of p. avidum, but in a smaller amount. furthermore, prostaglandin-like substances (pls) have been isolated from the lipid fraction of p. acnes. the ap antigens give rise to a precipitation reaction against a large proportion of normal sera. however, significantly higher antibody titre levels towards the ap fraction were found in patients with severe acne vu ... | 1980 | 6453560 |
| enzyme activities in spleen lymphocytes of tumor-bearing rats, and effect of propionibacterium acnes, bcg, and toxohormone on the enzyme activities in spleen lymphocytes of rats. | | 1981 | 6453649 |
| modulation of suppressor mechanisms in allergic contact dermatitis: 1. effect of c. parvum on the induction phase of contact allergy. | the effect of a pretreatment with corynebacterium parvum (c. parvum) on contact allergy in balb/c mice was studied. mice sensitized with 50 microliter (supraoptimal dose) 2.4-dinitrofluorobenzene (dnfb, 0.5%) showed a suppressed response as measured by ear swelling after painting the right ear with 0.3% dnfb in comparison to an allergic response obtained with an optimal sensitization dose (15 microliter dnfb 0.5%). by transfer of spleen cells from donors sensitized with a supraoptimal or an opti ... | 1981 | 6453904 |
| reduction of bacterial skin flora during oral treatment of severe acne with 13-cis retinoic acid. | | 1981 | 6454395 |
| acne vulgaris: therapy directed at pathophysiologic defects. | an effective therapeutic regimen for the treatment of acne vulgaris is presented. the emphasis is based upon correcting a defect in keratinization of the sebaceous follicles with a combination of vitamins a and e. this prevents the formation of milia and comedones, thus depriving the propionibacterium acnes of a culture medium. vitamin e also prevents irritating lipid peroxidation of sebum, damaged by bacterial growth, which may be responsible for the inflammatory aspects of acne. no antibiotics ... | 1981 | 6455256 |
| [propionibacterium acnes in acne vulgaris (comparative biochemical study of the comedone and the pustule]. | the biochemical properties of the propionibacterium acnes in 22 patients with inflammatory acne vulgaris was studied. group i/ii was found in most cases. there was no difference between the biochemical properties of the comedone and the pustule. the authors suggest that factors other than those depending on the pa degradative metabolism can be responsible for the purulent inflammatory process of the pil-sebaceous follicle. | 1980 | 6455573 |
| the role of propionibacterium acnes in the pathogenesis of acne. | | 1981 | 6456241 |
| [leukocyte migration inhibition factor in acne vulgaris]. | the inhibition factor of the leucocytic migration was studied in 26 patients with acne vulgaris, stages iii and iv, being positive in all the cases. the lif positive shows the mobilisation of lymphocytic population, answering an active and constant immunologic conflict. as the pa is antigenic, because it produces a blastification (ttl positive), we can say that it acts as antigen provoking immunologic mechanisms which help to explain the inflammatory processes at the pilo-sebaceous follicle in t ... | 1980 | 6456387 |
| [physiopathological mechanisms in acne vulgaris]. | the physiopathological mechanisms of the different degrees of the acne vulgaris are reviewed. the observations show the important antigenic activity of the "propionibacterium acnes" and the cellular immunity in the inflammation. an immunologic concept could explain this process. | 1981 | 6457226 |
| [immunology in surgery]. | | 1981 | 6457260 |
| activation and mechanism of action of suppressor macrophages. | | 1981 | 6457695 |
| immunosuppression of marrow b lymphocytes by administration of corynebacterium parvum in mice. | | 1981 | 6457877 |
| modulation of suppressor mechanism in allergic contact dermatitis. iv. selective inhibition of suppressor t-lymphocytes by serum obtained from corynebacterium parvum treated mice. | we have previously shown that corynebacterium parvum treatment reduced tolerance induced by intravenous injection of 2,4-dinitrobenzene sulfonic acid (dnbso3) or by sensitizing balb/c mice with a supraoptimal dose of 2,4-dinitrofluorobenzene (dnfb). further analysis by transfer experiments revealed that the generation and/or functional expression of suppressor t-lymphocytes (ts-cells) was inhibited in both tolerance models. inhibition of ts-cells was not entirely correlated with suppression of m ... | 1981 | 6458637 |
| hybrid resistance to el-4 lymphoma cells. ii. association between loss of hybrid resistance and detection of suppressor cells after treatment of mice with 89sr. | (c57bl/6 x dba/2)f1 hybrid (b6d2f1) mice resist the growth of parental-strain (b6) el-4 lymphoma cells inoculated intraperitoneally; that is, b6d2f1 mice survive longer than b6 mice and do not develop ascites. as compared with b6 mice, b6d2f1 mice have higher levels of natural killer (nk) activity against 51cr-labelled el-4 cells in their lymphoid organs. b6d2f1 mice treated with 89sr lose nk activity for certain lymphoma cell targets, e.g. yac-1, but nk(el-4) function is usually intact. however ... | 1981 | 6458878 |
| neuraminidase production by propionibacterium acnes-strains isolated from patients with acne vulgaris, seborrheic eczema and healthy subjects. | among cutaneous propionibacteria, synthesis of neuraminidase is highest in strains of the species p, acnes. in the present study, neuraminidase activity was discovered in 90.0% of p. acnes strains isolated from acne lesions compared with 72.7% of strains from normal human skin. neuraminidase-positive strains from acne lesions, moreover, produced statistically significant higher amounts of the enzyme (x = 727 microunits/ml bacterial suspension) than isolates from normal skin (x - 392 microunits/m ... | 1981 | 6458977 |
| follicular ph and the development of acne. | | 1981 | 6460005 |
| immunomodulation by cancer chemotherapeutic agents and antineoplastic activity. | | 1981 | 6460217 |
| [pathomechanism of acne vulgaris]. | | 1981 | 6460271 |
| tetracycline and minocycline treatment. | the effect of 1,000 mg of tetracycline hydrochloride and 200 mg of minocycline hydrochloride on propionibacterium acnes levels and skin-surface lipid levels was measured in 15 patients with acne. minocycline produced a significantly greater reduction in the p acnes counts that persisted even up to three weeks after discontinuation of the minocycline therapy, in contrast to the return of p acnes to baseline counts within three weeks after discontinuation of tetracycline therapy. a similar persist ... | 1982 | 6460472 |
| in vitro cytochemical and cytophysiological study of in vivo activated mouse peritoneal macrophages. | the morphological, cytochemical (acid phosphatase activity) and cytophysiological (phagocytosis) features of mouse peritoneal macrophages activated in vivo by two bacterial agents. corynebacterium parvum parvum and polidin, were investigated in vitro. both immunostimulants induced an increase in cytochemical and phagocytic activities of the activated peritoneal macrophages but in different degrees, the changes being more extensive in the case of corynebacterium parvum-activated macrophages. | 1981 | 6460939 |
| osteomyelitis of cervical spine from propionibacterium acnes. | | 1982 | 6461331 |
| action of isotretinoin in acne rosacea and gram-negative folliculitis. | good to excellent clinical results have been obtained in the treatment of severe inflammatory acne (acne conglobata, acne fulminans, and acne conglobata with hidradenitis and dissecting cellulitis of the scalp) with orally administered isotretinoin (13-cis-retinoic acid). similar promising results have been obtained in patients with severe rosacea and gram-negative folliculitis. isotretinoin probably has multiple modes of action, including (1) inhibition of sebaceous gland activity, (2) inhibiti ... | 1982 | 6461680 |
| the effect of nonspecific immune stimulation with corynebacterium parvum and polidin on the ehrlich ascites tumor growth. | investigations were performed: a) to compare the effect of two nonspecific immunostimulants, polidin and corynebacterium parvum, on the development of ehrlich ascites carcinoma in mice; b) to determine whether the effects are dependent on the tumor cell dose inoculated into the animals. c. parvum and polidin administered prior to ehrlich ascites tumor inoculation have a protective effect evidenced by a delay in tumor development, a retardation in tumor growth and a prolonged survival of the tumo ... | 1982 | 6461826 |
| phospholipase c of an oral strain of propionibacterium acnes purification and partial characterization. | phospholipase c of the oral propionibacterium acnes strain d 7 was purified from culture supernatants and partially characterized. the molecular weight was found to be 32.000 and the optimum ph was situated between 7.0 to 8.0. this nonhemolytic enzyme hydrolyzed relative intensively acidic glycerophospholipids and produced 1,2-diglyceride from phosphatidyl choline. | 1984 | 6464569 |
| adjuvant immunotherapy of n-[4(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced bladder tumors. | the prophylactic effect of maltose tetrapalmitate (mtp), a newly developed non specific immunoadjuvant in preventing or delaying bladder cancer induction by n-[4(5-nitro-2-furyl)-2-thiazolyl] formamide (fanft) or in reducing the growth rate of the induced tumor was compared to other well-known immunoadjuvants (bcg, c. parvum, levamisole and pyran copolymer). the evaluation of the prophylactic role of immunoadjuvants demonstrated that mtp, levamisole and c. parvum were the most effective in prolo ... | 1984 | 6465859 |
| effects of soluble mediators generated during growth of the landschütz ascites carcinoma on the chemotaxis of normal and corynebacterium parvum-stimulated peritoneal leucocytes. | the influence of ascites fluid on the chemokinetic and chemotactic responses of mouse peritoneal leucocytes was investigated using modified boyden chambers and the 'leading front' technique. the migration of normal cells towards endotoxin-activated mouse serum was significantly enhanced at high concentrations of fluid (40 and 20%) but was inhibited at lower concentrations (5 and 1%). by comparison, the chemotactic responsiveness of cells harvested 3 days after corynebacterium parvum (c. parvum) ... | 1984 | 6466553 |
| role of vasoactive amines in the antitumor activity of endotoxin. | to estimate a possible role of vasoamines in the antitumor action of endotoxin, effects of isoproterenol, serotonin and adrenaline on subcutaneously transplanted murine meth a sarcoma and the capacity of these agents to elicit antitumor factors were studied. macroscopically all agents induced tumor necrosis and a temporal tumor growth stop, but only endotoxin was capable of induction of complete tumor regression. histology showed that all agents induced hyperemia by 4 h and hemorrhagic necrosis ... | 1984 | 6469605 |
| role of inflammatory neutrophils in antitumor effects induced by intraperitoneal administration of corynebacterium parvum in mice. | we studied the role of inflammatory neutrophils in the antitumor effects that follow i.p. injection of corynebacterium parvum (1400 micrograms) into c3heb/fej mice challenged with the murine ovarian teratocarcinoma. peritoneal neutrophils, obtained from mice 6 hr after injection of c. parvum, exerted significant antitumor effects when injected admixed with murine ovarian terato-carcinoma cells into the peritoneal cavities of normal mice. treatment of recipient mice with whole-body irradiation or ... | 1984 | 6488171 |
| augmentation of organ-associated natural killer activity by biological response modifiers. isolation and characterization of large granular lymphocytes from the liver. | natural killer (nk) activity in the rat and human has been attributed to cells having the morphology of large granular lymphocytes (lgl). however, this association has been less clear in the mouse, largely because of difficulties in obtaining highly enriched populations of lgl from normal spleen and blood. we have previously observed that the administration of the biological response modifier (brm) maleic anhydride divinyl ether (mve-2) strongly augmented nk activity in lung and liver, and the a ... | 1984 | 6491601 |
| [influence of corynebacterium parvum, bcg, ok-432 and lactobacillus casei on the hepatic drug-metabolizing systems and on the oxygen radical production by fixed macrophages in liver of balb/c mouse]. | | 1984 | 6491874 |
| [antitumor activity of bacterial fractions and related synthetic compounds]. | we have purified the cell-wall skeletons (cws) of mycobacterium bovis bcg, nocardia rubra, propionibacterium acnes and listeria monocytogenes as the adjuvant-active principles of these bacterial cells. these cell-wall skeleton preparations were shown to have antitumor activities in experimental tumor systems. especially bcg-cws and n. rubra-cws were applied for the treatment of human cancer. the synthetic immunoadjuvants such as cord factor, mycoloyl and quinonyl derivatives of n-acetylmuramyldi ... | 1984 | 6508322 |
| bimodal effects of mve-2 on cytotoxic activity of natural killer cell and macrophage tumoricidal activities. | maleic anhydride divinyl ether of molecular weight 15,500 (mve-2) increased tumoricidal activity of nk cells and m phi in a dose-dependent manner with the peak response of both effector cells occurring 3 days following treatment. both effector cell responses were sustained for over 7 days following one injection. however, repeated injections with mve-2 led to a hyporesponsiveness of nk cells whereas m phi activity remained high. poly iclc, but not c. parvum, reconstituted nk cell activity in mic ... | 1984 | 6511143 |
| [studies on experimentally induced acute hepatic failure: the significance of adherent cell activation in the liver]. | | 1984 | 6513114 |
| the importance of parasite load in the killing of plasmodium vinckei in mice treated with corynebacterium parvum or alloxan monohydrate. | mice pre-treated with corynebacterium parvum and later challenged with plasmodium vinckei become infected but do not die whereas control mice do. when pre-treated mice were challenged with 1, 10, 1 x 10(2), 1 x 10(4), 1 x 10(5) or 1 x 10(6) parasites, the pre-patent periods correlated directly with the number of parasites injected, but the subsequent parasitaemias reached similar levels. this suggests that parasite killing, resulting from pre-treatment with c. parvum, is not triggered until the ... | 1984 | 6514377 |
| influence of ph on porphyrin production in propionibacterium acnes. | propionibacterium acnes was grown on eagle's medium for 4-15 days at ph 5.3-7.2 the porphyrin production was measured both by direct fluorometry and by high pressure liquid chromatography (hplc). the greatest concentration of porphyrins was produced at ph 6.1. protoporphyrin was the dominant porphyrin species present in the bacteria in all samples. the relative amount of coproporphyrin was greatest at ph 6.7 after 4 days of incubation. in human skin there are local variations in the ph; therefor ... | 1984 | 6517611 |
| the effect of the immunomodulator corynebacterium parvum on hemisplenectomized mice. | the immunomodulator corynebacterium parvum stimulates the reticuloendothelial system and causes splenic hypertrophy. the ability of c parvum to stimulate splenic regeneration in hemisplenectomized mice and decrease susceptibility to intranasal pneumococcal challenge was studied. mice were divided into two groups, control sham-operated (n = 48) and hemisplenectomized (n = 47) animals. ten days later, each group was divided into two subgroups, those injected with c parvum (700 mcg ivp) and those i ... | 1984 | 6520680 |
| effect of some immunomodulators on the delayed-type hypersensitivity to nonviable mycoplasma pulmonis in mice. | | 1984 | 6521151 |
| an electrophoretic analysis of superoxide dismutase in campylobacter spp. | superoxide dismutase (sod, superoxide:superoxide reductase, ec 1.15.1.1) activity was studied in 23 strains of campylobacter spp. using disc polyacrylamide gel electrophoresis. different enzyme patterns were observed with extracts of different species of campylobacter; three migration bands were found in all strains of c. sputorum subsp. sputorum and c. sputorum subsp. bubulus (relative mobilities, rm, 0.57, 0.76 and 0.85), and c. fetus subsp. fetus (rm 0.60, 0.72 and 0.81), while four migration ... | 1984 | 6527124 |
| fatty acid composition of a propionibacterium acnes vaccine and its relationship to immunostimulatory activity. | the distribution of lipids of propionibacterium acnes (corynebacterium parvum) vaccine strain in chloroform-methanol, ethanol and light petroleum extracts was determined. firmly bound lipids released by hydrolysis were also investigated. the petroleum extract differs from other lipidic fractions in its fatty acid composition. the presence of linolic, tuberculostearic and 10-ketostearic acids and branched fatty alcohols was observed in addition to previously described fatty acids of p. acnes. cha ... | 1984 | 6532023 |
| [composition of normal bacterial flora of human skin in relation to the age and sex of examined persons]. | | 1984 | 6536032 |