| a microsporidan contaminant of a nonhuman primate cell culture: ultrastructural comparison with nosema connori. | | 1979 | 109606 |
| inhibition of rat passive cutaneous anaphylaxis by 3-(tetrazol-5-yl)quinolines. | quinoline-3-carboxylic acid (3) was found to have weak oral activity in the rat passive cutaneous (pca) assay. in an effort to increase activity, the synthesis of structurally related compounds was initiated. this led to substituted 3-(tetrazol-5-yl)quinolines, some of which are equal in potency, when given orally, to doxantrazole. further work resulted in the synthesis of 4-oxoquinolines, one of which, 8-chloro-1,4-dihydro-4-oxo-3-(tetrazol-5-yl)quinoline (132), is 33-fold more active than diso ... | 1979 | 109613 |
| human granulocyte and reticuloendothelial system function during intralipid infusion. | in six patients, the phagocytic and catabolic functions of the res (reticuloendothelial system), as measured by using 125i-microaggregated human serum albumin as a test substance, were not affected by intralipid infusion. the nitroblue tetrazolium (nbt) reduction of granulocytes, the nbt reduction and the bacplasma, was significantly lower in eight patients during intralipid infusion than before this treatment. when heat-killed e. coli were added for phagocytic stimulation in vitro, the same res ... | 1978 | 109632 |
| effect of controlled electromagnetic radiation on the growth of cells in tissue culture. | | 1979 | 109700 |
| major sex-determining genes. | | 1978 | 109750 |
| the emergence of antimicrobial resistance in new zealand. | | 1979 | 109800 |
| studies on the synthesis of plasmid-coded proteins and their control in bacillus subtilis minicells. | | 1979 | 109873 |
| pseudomonas resistance to gentamicin. | 66 burned patients admitted to the burn unit from jan. to sept., 1977, were studied. topical therapy employed was mafenide or silver sulfadiazine. the most common pathogens isolated in 288 burn wound cultures were pseudomonas aeruginosa (42%), klebsiella-enterobacter (16%), and staph, aureus (13%). pseudomonas was sensitive to gentamicin in only 36.2% of instances. in 1976, 42% of pseudomonas isolates was sensitive. during the period 1969-1973, 85.7% of the pseudomonas was sensitive to gentamici ... | 1979 | 109913 |
| identification and evaluation of noninvasive blood pressure measuring techniques. | | 1979 | 109947 |
| theoretic and experimental analysis of the ability of a commercially prepared system to detect mixtures of bacteria. | the validity of the biochemical identification of bacteria presumes that the inoculum consists of a pure growth of bacteria. the detection of mixtures of bacteria with the analytab enteric (api 20e) system was tested. using a computer to predict the response of the api 20e system to mixed cultures, the presence of a mixture was not detected in 15% of all pairwise combinations of 324 common organisms of the enterobacteriaceae family and in 19% of all pairwise combinations of enterobacteriaceae wi ... | 1979 | 110136 |
| host selection patterns of some pakistan mosquitoes. | the host selection patterns of 18 species of pakistan mosquitoes are described, emphasizing the presumed malaria vectors, anopheles culicifacies, an. fluviatilis, and an. stephensi, and the probable vectors of west nile virus, culex pipiens fatigans and cx. tritaeniorhynchus. all species tested, with the exception of cx, p. fatigans, were considered to be essentially zoophilic. few human feeds were recorded for an. annularis (0.7%), an. culicifacies (0.5%), an. fluviatilis (1.1%), an. nigerrimus ... | 1979 | 110157 |
| epidemiologic studies among amerindian populations of amazônia. i. pyoderma: prevalence and associated pathogens. | pyoderma was studied among a representative sample of the residents of four remote amerindian villages, amazonas state, brazil, during july-august 1976. the overall prevalence among the 775 inhabitants examined was 11%, with little intervillage variation. when the attack rates for the entire sample population were calculated by 5-year age intervals, the 0- to 4-year-olds had the highest rate, 31%. the highest prevalence, 38%, was found among 3-year-olds. attack rates were not apparently related ... | 1979 | 110164 |
| iron requirement and chelator production of staphylococci, streptococcus faecalis and enterobacteriaceae. | the effect of iron deprivation on growth of 101 aerobic strains of gram-positive and gram-negative bacteria was studied on agar media in the presence of various concentrations of the synthetic iron chelator ethylene diamine diorthohydroxyphenyl acetic acid (edda) and the iron binding protein transferrin. growth of staphylococcus epidermidis was inhibited by 15 mm edda and 1.5 mm transferrin. staphylococcus aureus was only inhibited by 44 mm edda and not by transferrin. none of the strains of s. ... | 1978 | 110252 |
| waldenström's macroglobulinemia associated with a mixed cryoglobulin. report of a case with partial precipitation in vitro at 37 degrees c. | a 68-year-old man had waldenström's macroglobulinemia associated with a mixed cryoglobulin (monoclonal igm kappa and polyclonal igg, 0.96 g/dl) manifested by purpura, weight loss, hepatosplenomegaly, and proteinuria. on cooling of serum warmed to 50 degrees c, the cryoglobulin begins to precipitate above 40 degrees c, with substantial precipitation at body temperature. incubation at 37 degrees c (after equilibration at 50 degrees c) causes approximately two thirds of the cryoglobulin to precipit ... | 1979 | 110284 |
| a new principle of injectable depot contraceptives. i drug selection and studies in monkeys. | the aim of the investigations was to develop a long-acting depot contraceptive on the basis of norethisterone or levonorgestrel. disappointing results with levonorgestrel nonanoate and levonorgestrel undecylate showed that elongation of the fatty acid, esterified with the steroid, decreased the bioavailability of the latter due to incomplete hydrolysis of the ester. therefore, several new compounds were synthesized which contained a bifunctional molecule between the steroid and the fatty acid. i ... | 1979 | 110513 |
| the comparative efficacy of minocycline and penicillin-v in staphylococcus aureus skin and soft tissue infections. | the antistaphylococcal properties of orally administered minocycline and penicillin-v were compared for one hundred and fifteen patients receiving minocycline and one hundred and twenty-eight receiving penicillin-v for various types of cutaneous infections. the majority of bacterial isolates were staphylococcal organisms. of these 82 percent showed initial in vitro sensitivity to minocycline while only 20 percent did to penicillin-v. the percentage of clinical cures was higher with minocycline ( ... | 1979 | 110520 |
| fetal response to thyrotropin-releasing hormone after thyroid hormone administration to the rhesus monkey: lack of pituitary suppression. | | 1979 | 110579 |
| further studies on the effects of lesions in the rostral hypothalamus on gonadotropin secretion in the female rhesus monkey (macaca mulatta). | bilateral radiofrequency lesions were stereotaxically placed in the rostral hypothalamus of four adult female rhesus monkeys. these lesions resulted in extensive destruction of the ventromedial preoptic-anterior hypothalamic area (poa-aha) and included the suprachiasmatic nucleus as well as, with the exception of one animal, the organum vasculosum of the lamina terminalis. in three of these four animals, gonadotropin surges similar to those observed before surgery were elicited in response to ei ... | 1979 | 110581 |
| the distribution and concentration of thyrotropin-releasing hormone in discrete human hypothalamic nuclei. | | 1979 | 110582 |
| deoxyribonucleic acid sequence common to staphylococcal and streptococcal plasmids which specify erythromycin resistance. | plasmids from erythromycin-resistant staphylococcus aureus, streptococcus sanguis, and streptococcus faecalis show deoxyribonucleic acid sequence homology. the homologous sequences can be localized to specific restriction endonuclease fragments, which in the case of s. aureus plasmid pi258 involves a single fragment from either ecori or hindiii digest known to contain the erythromycin resistance determinant. complementary ribonucleic acid probes prepared from s. aureus plasmid pi258 and s. sangu ... | 1979 | 110774 |
| the primary structure of the alpha subunit of protocatechuate 3,4-dioxygenase. i. isolation and sequence of the tryptic peptides. | the carboxymethylated alpha subunit of protocatechuate 3,4-dioxygenase was digested with trypsin. the 14 tryptic peptides were isolated by ion exchange chromatography on deae-sephadex and by gel filtration chromatography. automated edman degradation and carboxypeptidase y and b digestion were used to establish the sequence of these peptides. further fragmentation of two tryptic peptides, t3 and t5, by staphylococcus aureus protease and cyanogen bromide, respectively, was necessary to complete th ... | 1979 | 110807 |
| standardization of direct susceptibility test for blood cultures. | insufficient data are available to establish the reliability of direct disk diffusion susceptibility tests performed utilizing positive blood culture broth as inoculum. when staphylococcus aureus atcc 25923, escherichia coli atcc 25922, and pseudomonas aeruginosa atcc 27853 were used, 0.03 ml of turbid overnight blood culture broth was found to produce zone diameters closely approximating the size of diameters obtained by a standardized method. results of direct (0.03 ml of inoculum) and standar ... | 1979 | 110825 |
| measurement of endotoxins with the limulus test in burned patients. | high titres of endotoxin as measured by the limulus test were usually found in burned patients who had raised body temperatures, and were colonized with gram-negative bacteria; also some infected patients showed raised endotoxin without a raised temperature. patients vaccinated with an antipseudomonas vaccine rarely showed endotoxin in their plasma but occasional plasma samples from vaccinated patients had a high titre of endotoxin which appeared unrelated to infection or to a raised temperature ... | 1979 | 110875 |
| effect of nutritional status and 5-fluorouracil on protein synthesis in parenterally alimented lew/mai rats. | lew/mal rats bearing transplantable adenocarcinomas were maintained parenterally for 4 days on 1) a regimen adequate in amino acids and glucose and 2) severely hypocaloric glucose. rats from both groups were given 17.5 mg 5-fluorouracil (fura)/kg/day as a continuous infusion for 3 days. cumulative nitrogen balance, fractional tissue protein synthesis rates, and liver and muscle distribution of fura and its metabolites were determined. results were compared to those found with a series of control ... | 1979 | 110969 |
| baseline blood chemistry determinations in the squirrel monkey (saimiri sciureus). | sera from 129 squirrel monkeys, saimiri sciureus, were analyzed for 15 chemical constituents. the values obtained were then analyzed for statistical significance causing the following sets of variables: (1) colony-bred versus noncolony-bred, (2) karyotype (3) vendor, (4) sex and (5) dietary iodine supplementation versus nonsupplementation. calcium, inorganic phosphorous, albumin, uric acid, blood urea nitrogen, glucose, alkaline phosphatase and potassium were high in colony-bred animals. cholest ... | 1979 | 110977 |
| a comparison of bacterial flora isolated by transtracheal aspiration and pharyngeal swabs in macaca fascicularis. | the pulmonary flora of 30 monkeys (macaca fascicularis) was sampled by the transtracheal aspiration technique and the pharyngeal swab method, and the results were compared. the transtracheal aspiration technique yielded lower numbers of bacteria in both aerobic and anaerobic cultures. the bacteria isolated by transtracheal aspiration were predominately pure culture, thereby lowering the possibility of contamination from commensal flora. bordetella bronchiseptica was isolated from 23.3% of the mo ... | 1979 | 110978 |
| physico- and immunochemical properties of staphylococcal protein a extracellularly produced by a set of mutants from staphylococcus aureus cowan i. | mutant strains of staphylococcus aureus have been isloated using a simple cosedimentation technique. while the parental strain contains predominantly a cell-bound protein a, the mutant strains exclusively produce extracellular protein a. the mutant forms of protein a all have lower molecular weights than that of protein a from the parental strain. they showed the same antigenicity as the parental protein a and gave similar reactivity with immunoglobulin to the parental one except for one mutant. ... | 1979 | 111003 |
| transfection of enterobacteriaceae and its applications. | | 1978 | 111022 |
| evidence for the protection of specific rna sequences in globin messenger ribonucleoprotein particles. | purified 15 s globin mrna-protein (mrnp) complexes obtained by edta dissociation of duck reticulocytes polyribosomes were digested with the calcium dependant staphylococcus aureus nuclease (ec 3. 1. 4. 7.). 25% of the globin mrna sequences were resistant to extensive nuclease digestion as determined by tca precipitation of the digested 15 s particles labelled in vivo with tritiated uridine. polyacrylamide gel electrophoresis of the rna from nuclease digested 15 s particles showed that the protec ... | 1979 | 111230 |
| effects of tube-feeding iso-energetic amounts of various dietary lipids on energy balance in the rat. | | 1979 | 111256 |
| tryptophan-free diet: effects on the acoustic startle reflex in rats. | in experiment 1, body weights of rats fed a powdered tryptophan-free (tf) diet decreased monotonically during a 13-day period. control animals fed the same diet supplemented with 0.5% l-tryptophan gained weight. the groups did not differ significantly in acoustic startle amplitude measured at 2, 4, 6, 7, 9, 11, and 13 days despite a 28% decrease in whole-brain serotonin in the tf rats. in experiment 2, daily intubation of rats with a syrup form of each diet maintained the two groups' body weight ... | 1979 | 111272 |
| progressive-ratio performance in the rhesus monkey maintained by opiate infusions. | | 1979 | 111282 |
| naloxone enhancement of dmt and lsd-25 induced suppression of food-rewarded bar pressing behavior in the rat. | the narcotic antagonist naloxone was tested to determine its possible interaction with n,n-dimethyltryptamine (dmt) and lysergic acid diethylamide-25 (lsd) in adult male holtzman rats trained to press a bar on a fixed-ratio four schedule (fr4), i.e., every fourth press earned a reward of 0.01 ml sugar sweetened milk. lsd (0.1 mg/kg) or increasing doses of dmt (1.0, 3.2, and 10.0 mg/kg) were administered i.p. to disrupt food-rewarded fixed ratio bar pressing in a dose related fashion. pretreatmen ... | 1979 | 111285 |
| naloxone effects on schedule-controlled behavior in morphine-pelleted rats. | the effects of morphine pellet implantation and naloxone administration were examined in rats lever pressing under inter-response time schedules of food presentation. subcutaneous implantation of a morphine pellet initially decreased lever-pressing rates. tolerance to this effect developed within 3--4 days. naloxone (0.25--1.0 mg/kg) decreased response rates in morphine-pelleted rats in a dose-dependent and time-dependent manner. all doses of naloxone severely decreased rates of lever pressing o ... | 1979 | 111298 |
| the protective effect of non-immunologic granulomatous inflammation in trypanosoma cruzi infection of mice. | | 1979 | 111311 |
| [meningitis caused by listeria monocytogenes]. | | 1979 | 111319 |
| interfering factors in the assay of plasminogen activators by the fibrin plate method. occurrence of different inhibitors against tissue plasminogen activator and urokinase. | the assay of plasminogen activator activities on fibrin plates was re-evaluated with special reference to fibrinolysis inhibitors present in samples and in fibrin plates. the nature, action and stability of inhibiting material were studied in tissue with considerable differences in activator and inhibitor contents: human lung, liver and placenta. extracts were tested for inhibitory capacity against purified human uterine tissue plasminogen activator, urokinase and plasmin of fibrin plates prepar ... | 1979 | 111368 |
| effects of the inhalation of manganese dioxide dust on monkey lungs. | | 1978 | 111373 |
| sarcosporidiosis in cattle in el salvador. | | 1979 | 111382 |
| experimental neurogenic bladder disorder in non-human primates. | these studies indicate that the monkey macaca nemestrina provides a suitable model to evaluate the neurological mechanism of micturition. this animal has a sacral spinal center for micturition whereby the classification of primary patterns of neurogenic disorder into spinal reflex after suprasacral spinal cord section and autonomous after cauda equina section is validated. attempts at dissociation of the spinal and vesical neurons by section of the cauda equina were characterized generally by ra ... | 1978 | 111389 |
| [dynamics of urea concentration in blood cells of the domestic fowl during early post-incubation ontogenesis]. | urea was determined by means of diacetyl monoxim in the blood cells of 80 cockerels of the initial breed white leghorn, commercial hybrid primant. the highest urea concentration was ascertained on the 15th day of life: 392.33 +/- 85 mg per 10(12) blood cells. the content of urea in the blood cells irregularly deceased with the age of the cockerels. the minimum urea concentration was obtained on the 40th day of post-incubation life: 63.40 +/- 56.5 mg per 10(12) blood cells. | 1979 | 111396 |
| [resistance of staphylococcus-aureus strains, isolated from food, to antibiotics]. | resistance to selected antibiotics was studied in 325 strains of staphylococcus aureus, isolated from foodstuffs. out of these strains, 50.46% were resistant to penicillin, 15.7% to ampicillin, 4% to streptomycin, 5.2% to erythromycin, 5.8% to chloramphenicol, 18.5% to tetracycline, 18.2% to oxytetracycline, 2.5% to gentamycin, 1.6% to canamycin, 53.5% to colistine and 9.2% to bacitracin. eighty-five strains (26.15%) were sensitive to all the antibiotics used; 107 strains (32.92%) were resistant ... | 1979 | 111401 |
| [cleavage of lactulose by bacillus megaterium]. | | 1978 | 111429 |
| neurotoxicity of sodium cyanate. new pathological and ultrastructural observations in maccaca nemestrina. | the effects of sodium cyanate (nanco) on the nervous system of maccaca nemestrina were studied at 2, 4, and 6 months of administration of the drug. the two groups injected with daily doses of 35 and 25 mg/kg/day of na-cyanate developed a predominantly demyelinating lesion in the pyramidal tracts of the spinal cord. no neuronal changes were observed in the motor cortex, basal ganglia, midbrain, medulla or anterior horn cells of the spinal cord. there was no evidence of peripheral neuropathy. a co ... | 1979 | 111462 |
| inhibitory effect of charcoal-treated porcine follicular fluid upon serum fsh levels and follicular development in the rhesus monkey. | injection of charcoal treated porcine follicular fluid into 4 intact, 4 long term castrate and 2 postmenopausal rhesus monkeys brought about a selective decline in serum fsh levels. luteinizing hormone levels were not significantly decreased. intraperitoneal injection of 4 ml porcine follicular fluid every 8 hours for the first 4 days of the menstrual cycle led to a decrease in follicle and granulosa cell growth observed at that midcycle. treatment with porcine serum did not exert this effect. | 1979 | 111474 |
| a golgi study of radial glial cells in developing monkey telencephalon: morphogenesis and transformation into astrocytes. | | 1979 | 111580 |
| [gentamycin activity in combination with etonium in relation to pseudomonas aeruginosa]. | gentamicin is one of the most effective drugs for treatment of infections caused by ps. aeruginosa. however, isolation of the strains resistant to the antibiotics was not infrequent. it was shown in the experiments with 40 cultures that the activity of gentamicin against ps. aeruginosa increased approximately 20 times when it was used in combination with ethonium, a derivative of bis-quaternary ammonium compounds. | 1979 | 111608 |
| [comparative electrophoretic properties of histones from trout and chicken erythrocytes and calf thymus at different concentrations of edta]. | an introduction of edta into an electrophoretic system was found to cause specific changes in the histone distribution patterns. the electrophoretic mobility of histones h3, h2b and h2a from three evolutionally unrelated sources (trout and chicken erythrocytes and calf thymus) is increased and that for histones h1 and h5 is decreased with respect to histone h4. in general the decrease of electrophoretic mobility of the histones in the presence of edta is correlated with the content of basic amin ... | 1979 | 111722 |
| [effects of s-adenosylmethionine and s-adenosylhomocysteine on in vivo synthesis of noradrenaline and serotonin in different parts of the rat brain]. | s-adenosylmethionine (0,1 mg/kg/ip) decreases in vivo, norepinephrine (ne) synthesis and does not affect 5-hydroxytryptamine (5 ht) synthesis in the rat brain. s-adenosylhomocysteine (7 mg/kg/ip) increases ne synthesis and decreases 5 ht synthesis. neither nucleoside affects dopamine synthesis. | 1979 | 111855 |
| the interaction of ligands with enzymes. a starting point in drug design. | the problem of inhibiting a specific enzyme of a pathogen without inhibiting the corresponding enzyme of the host is one which has intrigued medicinal chemists for years. while it is easy to find potent inhibitors of purified enzymes transforming these inhibitors into effective drugs, it still is a very poorly understood business. this report discusses studies with two enzymes, papain and dihydrofolate reductase, and the nonspecific (phi and mr correlated) interaction of ligands with them. the q ... | 1979 | 111968 |
| experimental bacterial keratitis in neutropenic guinea pigs: polymorphonuclear leukocytes in corneal host defense. | quantitative techniques were used to determine the relative concentrations of viable bacteria and polymorphonuclear leukocytes (pmns) in the corneas of neutropenic and non-neutropenic guinea pigs with experimental bacterial keratitis induced with three strains of pseudomonas aeruginosa. neutropenia was produced by whole-body x-irradiation 1 week before infection. significantly greater numbers of bacteria were present in the cornea of neutropenic animals 48 h after infection than were present in ... | 1979 | 112062 |
| bile salts, obstructive jaundice and renal blood flow. | | 1979 | 112085 |
| purification and partial characterization of rat liver bilirubin glucuronoside glucuronosyltransferase. | bilirubin glucuronoside glucuronosyltransferase (ec 2.4.1.95) converts bilirubin monoglucuronide to bilirubin diglucuronide and is concentrated in plasma membrane-enriched fractions of rat liver homogenates. the enzyme was purified 2,000-fold to homogeneity from rat liver. the pi of the enzyme is 7.9 +/- 0.2. the enzyme has a molecular weight of 160,000 and is an oligomer of 28,000 dalton subunits. km for purified enzyme was 35 microm and vmax was 2.2 mumol of bilirubin diglucuronide formed/min/ ... | 1979 | 112100 |
| intravenous feeding in a gastroenterological unit: a prospective study of infective complications. | we have assessed the bacteriological safety of a system of intravenous feeding by culturing catheters on removal, swabs taken from the catheter's skin entry sites, and samples of infusion fluid. among 38 treatment periods using 51 catheters over 1551 patient days, septicaemia due to staphylococcus aureus was observed in one treatment period and bacteraemias due to staphylococcus albus and diphtheroid species in two others. the staph. aureus and the diphtheroids probably gained access via the ski ... | 1979 | 112124 |
| very low frequency and small intensity electromagnetic and magnetic fields as an oecological factor. | the effect on microorganisms of electromagnetic and magnetic fields (emf, mf), the frequency and intensity of which were similar to natural ones, was studied. they were found to influence the physiology of bacteria. changes in the rate of proliferation of microbes, in their susceptibility to antibiotic the frequency of formation of recombinants and partial diploids during conjugation of colibacterium were observed during cultivation in these fields. | 1978 | 112178 |
| effect of thyrotropin releasing hormone instillation on canine senile cataracts. | | 1979 | 112310 |
| [clinical evaluation of cefazedon on patients with urinary tract infections (author's transl)]. | the efficacy and tolerance of cefazedon, a new antibiotic, was investigated clinically on 90 patients with urinary tract infections who also required surgical treatment. good clinical results were achieved in over 90% of patients after 6 to 7 days of treatment. the bacteriological examination revealed complete elimination of the initially identified pathogens in 89 cases. no difference in treatment results could be established when applying the dose 2 or 3 times daily. on the third day of treatm ... | 1979 | 112365 |
| [resistance to tetracycline and doxycycline in bavaria (author's transl)]. | the in vitro sensitivity of tetracycline and doxycycline is compared. streptococcus and staphylococcus are more sensitive to doxycycline whereas pseudomonas and proteus spec. are more sensitive to tetracycline. | 1979 | 112366 |
| [microbiological analysis of the results of treatment of urinary tract infections with epicillin]. | | 1979 | 112587 |
| [periosteal new bone formation in the horse induced by trauma. (author's transl)]. | the radiological interpretation of periosteal new bone formation in the horse induced by trauma is described and illustrated by some casereports. the better the margins of the new bone can be defined the lesser the activity. the greater the density of the new bone, the longer the duration of time since injury. | 1979 | 112712 |
| a study of leptospirosis among animals in barbados w.i. | microscopic agglutination tests performed during 1971 and 1972 on barbadian livestock showed positive serological reactions for leptospirosis as follows: cattle 51%, pigs 13%, sheep 18%, horses 64% and goats 19%. the serogroup autumnalis predominated in all but horses in which the reactions to the pyrogenes group appeared slightly higher. after the isolation of a strain of leptospira serotype fort-bragg (barbadian strain no. 119) of the autumnalis serogroup in 1973, and its subsequent inclusion ... | 1979 | 112729 |
| [magnetotherapy in infected open bone fractures]. | | 1979 | 112779 |
| immunization against bovine tropical theileriosis, using 60co-irradiated infective particles of theileria annulata (dschunkowsky and luhs 1904) derived from ticks. | portions of ground supernate material from theileria annulata-infected and prefed adults of the hyalomma anatolicum anatolicum were irridiated by 60co source at 0, 3, 5, 6, 7, or 9 krads. these portions were injected subcutaneously into different groups of cross-bred calves. the calves injected with 0-, 3-, or 5-krad irradiated tick supernate had severe reactions (rectal temperature 39.8 to 41.6 c, two- to fourfold enlargement of prescapular lymph gland, mean peak parasitemia 27.3% to 32.5% infe ... | 1979 | 112890 |
| antibacterial activity of a new parenteral cephalosporin--hr 756: comparison with cefamandole and ceforanide. | hr 756, a new parenteral cephalosporin that is beta-lactamase resistant, was tested against 271 bacterial isolates. both agar and broth dilution testing were employed, using two media and two inoculum sizes of bacteria. antibacterial activity of the drug was compared to that of cefamandole (cfm) and ceforanide (cfn). in agar, hr 756 was more active than cfm and cfn against all bacteria tested except isolates of staphylococcus aureus, which were better inhibited by cfm. hr 756 exhibited some anti ... | 1979 | 112919 |
| karyotypic abnormalities and clinical aspects of patients with multiple myeloma and related paraproteinemic disorders. | karyotypic abnormalities were detected in the malignant cells of 6 of 18 patients with multiple myeloma (mm). six patients with benign monoclonal gammopathy, one with amyloidosis of immunoglobulin origin, and two with waldenström's macroglobulinemia had normal karyotypes. all six mm patients with aneuploidy were in a group of 10 patients in an accelerated or relapse phase of their disease and four had high serum paraprotein levels (7.92, 6.24, 6.80, and 4.24 g/dl, respectively) when their abnorm ... | 1979 | 113076 |
| [topography of soluble gliofibrillar protein (gfa) in aged human brain]. | a great variation was observed in the amount of soluble gfa depending on the brain area. large amounts were found in the chiasma and in the pons whereas the cortical grey matter was poor. it is suggested that soluble gfa represents a potentiality of defense of the nervous tissue. | 1979 | 113120 |
| a comparison of the in vitro activity of tobramycin and gentamicin against 6,042 clinical isolates. | 6,042 strains of staphylococcus aureus, streptococcus faecalis, proteus mirabilis, escherichia coli, klebsiella sp. and pseudomonas sp. were tested against tobramycin and gentamicin. among all species studies, except pseudomonas sp, gentamicin turned out to be slightly superior to tobramycin. | 1979 | 113179 |
| the in vitro activity of mezlocillin when combined with cefoxitin or clavulanic acid. | | 1979 | 113377 |
| primary structure of a human iga1 immunoglobulin. v. amino acid sequence of a human iga lambda light chain (bur). | the sequence of the lambda light chain of the bur iga1 molecule has been determined. it comprises 214 amino acid residues with a blocked nh2 terminus and lacks carbohydrate. the v-region sequence is of the vlambdaii subgroup and contains the coupled interchanges arg-7 and cys-87. the lv3 region is comparatively short and hydrophobic in nature and lends support for the designation of this area as a hypervariable deletion region. the c-region exhibits the mcg+ kren+ oz- isotypes. these appear coup ... | 1979 | 113407 |
| heterogeneity of binding of human iga subclasses to protein a. | the ability of human iga myeloma immunoglobulins to interact with protein a-containing staphylococcus aureus was examined. some iga1 and iga2 immunoglobulins bound to s. aureus although others of both subclasses failed to do so. these results were obtained by using both direct binding of radiolabeled immunoglobulins to s. aureus and with inhibition-type assays. binding was dependent on the fc fragment of iga since there was no binding to s. aureus by an f(ab')2 fragment of iga1. nonprotein a-con ... | 1979 | 113457 |
| purification of antibodies to bacterial antigens by an immunoadsorbent and a method to quantify their reaction with insoluble bacterial targets. | a combination of procedures was employed to develop a radioimmunoassay which quantified the binding of antibodies to antigens of either intact propionibacterium acnes or to antigens of insoluble extracts derived from the bacteria. reactive antibody populations were purified by use of bacterial immunoadsorbents which were prepared by coupling p. acnes to diethylaminoethyl cellulose. binding of antibodies was detected with [125i]staphylococcal protein a ([125i]spa) and optimal conditions for the a ... | 1979 | 113462 |
| astrovirus infection in volunteers. | an extract and a filtrate prepared from feces of a child with mild gastroenteritis were shown by electron microscopy to contain numerous astrovirus particles and were given to eight volunteers by mouth. one subject developed diarrheal illness and concurrently shed large amounts of astrovirus in feces, and one other had mild constitutional symptoms with a lower level of virus shedding. nine other volunteers were given fecal filtrate from the volunteer with diarrhea, and astrovirus shedding subseq ... | 1979 | 113503 |
| use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis. | serum bactericidal titers against staphylococcus aureus were measured in 63 children who were receiving mafcillin or methicillin intravenously, or dicloxacillin, penicillin, or cephalexin orally. the sbts obtained following unit does of 25 mg/kg of dicloxacillin, 35 mg/kg of penicillin, or 25 mg/kg of cephalexin with probenecid were comparable to those seen following intravenous doses of 40 mg/kg nafcillin or methicillin. twenty-two children with acute hematogenous osteomyelitis proven or presum ... | 1979 | 113517 |
| different specific activities of the monomeric and oligomeric forms of plasmid dna in transformation of b. subtilis and e. coli. | (1) the low residual transforming activity in preparations of monomeric, supercoiled, circular (ccc) forms of the plasmids pc194 and phv14 could be attributed to the presence in such isolates of a small number of contaminating multimeric molecules. (2) e. coli derived preparations of phv14, as in vitro recombinant plasmid capable of replication in both e. coli and b. subtilis, contain oligomeric forms of plasmid dna in addition to the prevalent monomeric ccc form. the specific transforming activ ... | 1979 | 113646 |
| the effect of bilateral ventral noradrenaline bundle lesions on lever pressing for food in rats. | food reward has been associated with activation of noradrenergic mechanisms in the brain. using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food reward. we found that performance in the food-rewarded task was significantly impaired following such lesions, and that this was especially marked when the task was made more difficult ... | 1979 | 113830 |
| [non-specific positive milk ring test(s) in tank milk and estrumate in the treatment of cattle (author's transl)]. | the fact that non-specific milk ring tests were occasionally observed in tank milk provided the reason for doing a survey to detect the possible cause. among others, non-specific reactions were found to occur after treatment with estrumate. a regressing corpus luteum may also give rise to non-specific milk ring tests in animals which have not been treated with estrumate. | 1979 | 113907 |
| the relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice. | | 1979 | 114074 |
| diffusion disk susceptibility testing with cefotaxime. | the diffusion disk susceptibility of staphylococcus aureus, enterobacteriaceae, and pseudomonas aeruginosa to cefotaxime was determined. a 30-mug disk provided data for the susceptibility of p. aeruginosa, but yielded extremely large zones of inhibition against enterobacteriaceae. a 5-mug disk seemed to provide the most useful susceptibility data for s. aureus and enterobacteriaceae. | 1979 | 114106 |
| characterization of the exfoliative antispermatogenic agent 1-(2,4-dichlorobenzyl)-h-indazole-3-carboxylic acid in the rhesus monkey. | the effects of oral doses of 1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylic acid (dica) on spermatogenesis in the rhesus monkey (macaca mulatta) was studied. four animals given five daily 50 mg/kg doses or three or five daily 500 mg/kg doses showed that dica was an exfoliating antispermatogenic compound. the inhibition of spermatogenesis was only partially reversible following 500 mg/kg doses of dica. weekly and monthly 50 mg/kg doses of dica only partially inhibiting spermatogenesis as measure ... | 1979 | 114129 |
| effects of hyperbaric oxygen upon s. aureus, ps. aeruginosa and c. albicans. | numerous in vitro investigations have reported that prolonged, continuous hyperbaric oxygen (ohp) exposure to certain bacteria and yeast is bacteriostatic. while it is tempting to attribute the lower infection rates reported in ohp-treated patients to this bacteriostatic effect, the duration and intensity of ohp exposure in these experimental studies exceeds that of normal therapeutic use. this study was designed to investigate the effects of human ohp treatment protocols upon the in vitro growt ... | 1979 | 114160 |
| synergism between cefazedone and gentamicin in vitro. | | 1979 | 114188 |
| [specific phosphorylation of a calf serum protein by a kinase from the cell surface]. | a protein of molecular weight approximately 200,000, which exists in trace amounts in calf serum, is specifically phosphorylated by an enzyme located at the surface of cultured cells. the emzymatic reaction utilizes atp, is enhanced by mg++ and zn++ ions, and is not dependent on cyclic amp. this kinase activity is associated with normal growing fibroblasts but disappears when they are contact-inhibited. it remains high, however, in transformed and malignant cells, whatever their growth state. | 1979 | 114333 |
| acidic ribosomal proteins from eukaryotic cells. effect on ribosomal functions. | precipitation of saccharomyces cerevisiae ribosomes by ethanol under experimental conditions that do not release the ribosomal proteins can affect the activity of the particles. in the presence of 0.4 m nh4cl and 50% ethanol only the most acidic proteins from yeast and rat liver ribosomes are released. at 1 m nh4cl two more non-acidic proteins are lost from the ribosomes. the release of the acidic proteins causes a small inactivation of the polymerizing activity of the particles, additional to t ... | 1979 | 114391 |
| enzymatic measurement of adenine and guanine (plus inosine) triphosphates and diphosphates in isolated cells and the mitochondrial matrix compartment obtained from rat liver. | | 1979 | 114422 |
| in vitro interaction between normal cynolmolgus monkey alveolar macrophages and legionnaires disease bacteria. | the interaction between normal cynomolgus monkey alveolar macrophages and legionnaires disease bacteria was studied by transmission electron microscopy. after ingestion of legionnaires disease bacteria, the organisms replicated within macrophages and destroyed the phagocytic cell. | 1979 | 114492 |
| effect of concentration on bactericidal activity of cefotaxime. | | 1979 | 114510 |
| comparison of a slide coagglutination technique with the minitek system for confirmation of neisseria gonorrhoeae. | the phadebact gonococcus test was performed on 314 bacterial isolates to compare the coagglutination technique with the minitek system for the confirmation of neisseria gonorrhoeae. direct testing, using colonies of n. gonorrhoeae mixed with the phadebact gonococcus test reagents, produced noninterpretable results in many cases. however, an alternative method, described by the manufacturer, of heating several colonies in distilled water for 20 min before testing alleviated most interpretation d ... | 1979 | 114531 |
| measles in monkeys: an epidemiological study. | this study describes aspects of measles in non-human primates. monkeys infected before importation are shown to produce non-immune offspring in captivity in england. the high antibody titres found in most recently imported monkeys decline slowly during captivity in england. while measles is often fatal to monkeys, we have described an outbreak in which a number of symptomless infections occurred. histological examination of fatal cases produced evidence of infection in the wall of the urinary bl ... | 1979 | 114578 |
| central sites controlling pituitary secretion in the rhesus monkey. | | 1979 | 114716 |
| the diagnosis of gonorrhoea in women. | gonorrhoea was diagnosed in 258 of 1500 women. the diagnosis was made from urethral plus cervical cultures in only 184 cases (71.3%). the percentage of positive diagnoses rose to 96.5% when cervical smear microscopy was also performed. this highlights the need to carry out all three investigations. concurrent trichomonas infection was present in 14% of cases. | 1979 | 114741 |
| experimental infections with staphylococcus aureus, streptococcus sanguis, pseudomonas aeruginosa, and bacteroides fragilis in the jaws of dogs. | | 1979 | 114906 |
| [ultrastructural localization of the acetylcholinesterase (ache) activity in the diaphragm of the rat embryo (author's transl)]. | electron histochemistry revealed intense ache activity in the diaphragm of 15 days old rat embryos. the reaction product was localized to the perinuclear cisterna and the cisternae of the sarcoplasmic reticulum of myoblasts. the development of myoneural contacts at day 17 of gestation was preceded by the appearance of ache activity of muscle cells. sarcoplasmic cisternae and vesicles in the subjunctional sarcoplasm may play an important role in the development of the ache activity of the postjun ... | 1979 | 115211 |
| medical ethics and controlled clinical trials. | the controlled clinical trial is a relatively new phenomenon; the first large clinical trial on evaluation of streptomycin in therapy of pulmonary tuberculosis occurred in 1946. in such a study, two or more groups of patients with similar characteristics are chosen by random allocation to receive one or more therapies. the essential ethical dilemma is based on the risk-benefit ratio of the new therapy. ethical factors that must be considered in the design of controlled clinical trials include pr ... | 1979 | 115367 |
| sterilization by means of hydrogen chloride: influence of process parameters on biocidal activity. | | 1979 | 115827 |
| transcriptional regulation of escherichia coli k-12 major outer membrane protein 1b. | eleven independent insertion mutations were isolated that prevented expression of major outer membrane protein 1b. seven of the mutations were mucts insertions located at ombp. these ompb::mucts strains fell into two phenotypic classes with regard to expression of proteins 1a and 1b. the remaining four mutants were comprised of one tn5 and three mucts insertions mapping at par. the mucts insertions at par were used to construct fusions of the lac operon to the par promoter. expression of beta-ga ... | 1979 | 115844 |
| rabbit testis proacrosin. purification, molecular weight estimation, and amino acid and carbohydrate composition of the molecule. | | 1979 | 115871 |
| cephalosporin-sensitive penicillin-binding proteins of staphylococcus aureus and bacillus subtilis active in the conversion of [14c]penicillin g to [14c]phenylacetylglycine. | breakdown of the covalent complex formed between [14c]penicillin g and higher molecular weight, cephalosporin-sensitive penicillin-binding proteins was studied using mixtures of the purified proteins isolated from membranes of staphylococcus aureus and bacillus subtilis. these penicillin-binding proteins were found to release the bound 14c label in a first order process characterized by half-lives of 10 to 300 min at 37 degrees c. denaturation of the penicilloyl.penicillin-binding proctein compl ... | 1979 | 115876 |
| [profile of cefmetazole. ii. absorption, excretion, distribution and metabolism (author's transl)]. | | 1979 | 115937 |
| [initial bacterial flora in the throat and nose of newborns and effect of administration of chemotherapeutics to mothers on its establishment. (i) study of newborn babies (author's transl)]. | | 1979 | 115946 |
| experimental delayed radiation necrosis of the brain. part 1: effect of early dexamethasone treatment. | the authors have designed an experiment to detect a hitherto unrecognized interaction between high doses of the glucocorticoid, dexamethasone, and brain irradiation. eighteen juvenile male rhesus monkeys received 1800 rads to the whole brain in 8.5 minutes. for 1 1/2 days before and 10 1/2 days after the irradiation, nine animals received approximately 2.9 mg/kg/day of dexamethasone intramuscularly in addition to irradiation, while the remaining nine animals served as the control group and recei ... | 1979 | 115970 |