| phytochemical composition, anti-biofilm and anti-quorum sensing potential of fruit, stem and leaves of salvadora persica l. methanolic extracts. | emergence of antibiotic resistance among pathogenic bacteria encourages us to search for new molecules as an alternative treatment. the aim of this study was to evaluate the antiquorum sensing (anti-qs) and antibiofilm potential of salvadora persica l. methanolic extracts to prevent the infections due to staphylococcus as an alternate to antibiotics. the methanolic extracts of s. persica l. fruit, leaves and stems was assessed for their activity in inhibiting qs-depedent phenomenon such as viola ... | 2017 | 28552808 |
| novel rag1 mutation and the occurrence of mycobacterial and chromobacterium violaceum infections in a case of leaky scid. | severe combined immunodeficiency (scid) is a potentially fatal primary immunodeficiency (pid) that is caused by mutations in genes such as il2rg, jak3, il7ra, rag1, rag2, and ada. the products of these genes are involved in the development of several immune cells such as t, b and natural killer (nk) cells. most of the scid forms are autosomal recessive with the exception of il2rg defects that cause an x-linked scid. among the different scid types, there is a rare scid form called leaky scid, whi ... | 2017 | 28552805 |
| anti-quorum sensing activity of forsythia suspense on chromobacterium violaceum and pseudomonas aeruginosa. | quorum sensing (qs) plays an important role in the production of virulence factors and pathogenicity in pseudomonas aeruginosa, and the interruption of qs will be a hopeful pathway to combat bacterial infection. | 2017 | 28539728 |
| global transcriptional response to organic hydroperoxide and the role of ohrr in the control of virulence traits in chromobacterium violaceum. | a major pathway for the detoxification of organic hydroperoxides, such as cumene hydroperoxide (chp), involves the marr family transcriptional regulator ohrr and the peroxidase ohra. however, the effect of these peroxides on the global transcriptome and the contribution of the ohra/ohrr system to bacterial virulence remain poorly explored. here, we analyzed the transcriptome profiles of chromobacterium violaceum exposed to chp and after the deletion of ohrr, and we show that ohrr controls the vi ... | 2017 | 28507067 |
| anti-quorum sensing activity of some medicinal plants. | quorum sensing is the key regulator of virulence factors of pseudomonas aeruginosa such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. the aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of p. aeruginosa. | 2016 | 28487896 |
| bacteremia and urinary tract infection caused by chromobacterium violaceum: case reports from a tertiary care hospital in kathmandu, nepal. | chromobacterium violaceum is ubiquitous in the environment of tropical and subtropical regions but the infections caused by this organism are rare and the urinary tract infections caused by it are even rarer. due to the propensity for hematogenous spread leading to fatal sepsis, the infections caused by chromobacterium violaceum have high mortality rate (65-80%) with death occurring in as less as one week of acquiring infection. so, prompt proper treatment is necessary for successful treatment o ... | 2017 | 28479920 |
| glyceryl trinitrate is a novel inhibitor of quorum sensing in pseudomonas aeruginosa. | targeting quorum sensing is an alternative approach to antibiotics.targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. as a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria. | 2016 | 28479904 |
| imaging bacterial interspecies chemical interactions by surface-enhanced raman scattering. | microbes produce bioactive chemical compounds to influence the physiology and growth of their neighbors, and our understanding of their biological activities may be enhanced by our ability to visualize such molecules in vivo. we demonstrate here the application of surface-enhanced raman scattering spectroscopy for simultaneous detection of quorum-sensing-regulated pyocyanin and violacein, produced respectively by pseudomonas aeruginosa and chromobacterium violaceum bacterial colonies, grown as a ... | 2017 | 28460167 |
| a scalable metabolite supplementation strategy against antibiotic resistant pathogen chromobacterium violaceum induced by nad(+)/nadh(+) imbalance. | the leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. this study develops a novel systems biology driven approach for killing antibiotic resistant pathogens using benign metabolites. | 2017 | 28446174 |
| prospective bacterial quorum sensing inhibitors from indian medicinal plant extracts. | as virulence of many pathogenic bacteria is regulated by the phenomenon of quorum sensing (qs), the present study aimed to find the qs-inhibiting (qs-i) property (if any) in 61 indian medicinal plants. the presence of qs-i compound in the leaf extract was evaluated by its ability to inhibit production of pigment in chromobacterium violaceum mtcc 2656 (violacein) and pseudomonas aeruginosa mtcc 2297 (pyocyanin) or swarming of p. aeruginosa mtcc 2297. extracts of three plants, astilbe rivularis, f ... | 2017 | 28421612 |
| inhibition of hafnia alvei h4 biofilm formation by the food additive dihydrocoumarin. | quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism that is implicated in food spoilage caused by bacteria. thus, blocking qs may suppress qs-controlled phenotypes of these bacteria that are responsible for food spoilage. biofilm formation is closely related to bacterial infection, and it is also a major mechanism responsible for the increased resistance of biofilm-associated bacteria to antimicrobial drugs. food spoilage and biofilm formation caused by food-related b ... | 2017 | 28402186 |