| structure and function of the maize spm transposable element. | the spm's primary transcript is alternatively spliced to give at least 4 different transcripts which code for proteins with extensive overlapping domains. two of these proteins, the tnpa and tnpd gene products, are necessary and sufficient to promote dspm transposition in tobacco. moreover, the tnpa gene product is also sufficient to suppress the basal level of expression observed in some dspm-disrupted genes, and probably to activate the expression of inactive elements and of other dspm-disrupt ... | 1991 | 1851643 |
| analysis of the serratia marcescens proba operon and feedback control of proline biosynthesis. | the proba operon, coding for gamma-glutamyl kinase (gk) and gamma-glutamyl phosphate reductase (gpr), was cloned from the chromosome of the wild-type strain of serratia marcescens sr41. from our sequence data the prob (1101 bp) and proa (1472 bp) genes were shown to code for two proteins of mr 39,169 and 44,640, respectively. analysis of expression of the lacz structural gene fused with the proba promoter showed that the proba operon is not subject to proline-mediated feedback repression. amplif ... | 1991 | 1851803 |
| miniature manipulator with microelectrode for chronic recording of single units from freely-moving animals. | we report a simple recording and stimulating system, a miniature manipulator with a microelectrode (mmm) that can be mounted on animal's skull. the system consists of a miniature manipulator and a microelectrode which are used in one body. several mmms can be implanted simultaneously into the brain as the part of the manipulator is small. with this device, recording of single units from several different cortices is possible from awake and unrestricted animals. | 1991 | 1851979 |
| high blood pressure during pregnancy and working conditions among hospital personnel. | the relationship between working conditions and high blood pressure during pregnancy was analysed in a sample of 621 women hospital employees in the paris region over the period 1979-1981. data were collected by interviews during the routine medical visit at the end of postnatal leave. women who had to work standing up for extended periods of time, who had to carry heavy loads or who had to perform heavy cleaning tasks had high blood pressure during their pregnancy more often than women not expo ... | 1991 | 1855606 |
| validation of protocols for assessing early pregnancy failure in the rat: clomiphene citrate. | a battery of protocols for the assessment of maternally mediated toxicity during early pregnancy in the rat is being evaluated for its utility in detecting and defining mechanisms of early pregnancy failure. in this report, clomiphene citrate (cc), an estrogen agonist/antagonist, was used as a model compound in this evaluation process. the protocols involve dosing rats with cc during, and evaluation of multiple endpoints following, (a) the first 8 days of pregnancy; (b) early pseudopregnancy, ac ... | 1991 | 1855622 |
| antimutagenic and anticarcinogenic effects of betel leaf extract against the tobacco-specific nitrosamine 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk). | earlier studies showed that betel leaf inhibits the mutagenic action of standard mutagens like benzo[a]pyrene and dimethylbenz[a]anthracene. since tobacco-specific nitrosamines are the major carcinogens present in unburnt forms of tobacco, we studied the effect of an extract of betel leaf on the mutagenic and carcinogenic actions of one of the most potent, 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk). betel-leaf extract and hydroxychavicol suppressed the mutagenicity of nnk in both th ... | 1991 | 1855909 |
| concomitant dissemination of three extended-spectrum beta-lactamases among different enterobacteriaceae isolated in a french hospital. | from january 1988 to august 1989, 267 non-repetitive strains of enterobacteriaceae producing extended-spectrum beta-lactamases (esbla) derived from tem (ctx-1/tem-3, caz-6) or shv (caz-5) were isolated from 219 colonized or infected patients. esblas were characterized by analytical isoelectric focusing. biotypes, resistance phenotypes and plasmid patterns were determined in order to differentiate the isolates in each species. among the 116 ctx-1-producing enterobacteriaceae, 48 strains were diff ... | 1991 | 1856124 |
| arterial wall and smooth muscle cell development in young wistar rats and the effects of surgical denervation. | development of the muscular saphenous artery and the effect of surgical denervation on normal development was investigated in young rats at 3 and 6 weeks of age. during this interval, the weight and blood pressures (systolic, diastolic, and mean) of the animals increased significantly. the tunica media of the artery and the lumen increased significantly with age, but the proportion of smooth muscle cell to paracellular matrix did not alter. computer-assisted three-dimensional reconstructions wer ... | 1991 | 1860184 |
| susceptibility of xanthomonas maltophilia and amikacin-resistant gram-negative bacteria to newer antimicrobials. | the susceptibility of xanthomonas maltophilia and amikacin-resistant gram-negative bacteria to a variety of newer antimicrobials was determined. sixty-three amikacin-resistant isolates were collected from 61 inpatients at a tertiary-care hospital between 1985 and 1988. the organisms included xanthomonas maltophilia (24 isolates), pseudomonas aeruginosa (16), pseudomonas species (3), serratia marcescens (10), flavobacterium meningosepticum (4), enterobacter species (3), acinetobacter calcoaceticu ... | 1991 | 1860303 |
| [induced bacterial chemiluminescence]. | oxygen-peroxide-induced superweak luminescence of some microorganisms has been studied by means of the native chemiluminometer khlm1ts-01. it is established that total chemiluminescence decrease in the bacteria as follows: escherichia coli----bacillus subtilis----proteus vulgaris----bacillus mycoides----b. licheniformis----pseudomonas aeruginosa----staphylococcus epidermidis----s. aureus----serratia marcescens----salmonella enteritidis. a hypothesis is put forward on a possible mechanisms of app ... | 1991 | 1861655 |
| [malaria. quid novi?]. | | 1991 | 1863604 |
| mode of antibacterial action of cefprozil, a new cephalosporin, on escherichia coli, serratia marcescens and morganella morganii. | the mode of antibacterial action of cefprozil (cfpz, bmy-28100), a newly developed cephalosporin, was investigated using escherichia coli k12, serratia marcescens ifo 12648 and morganella morganii ifo 3848 as test organisms, in comparison with the action of cefaclor (ccl). the minimum inhibitory concentrations (mics) of cfpz for these organisms were 1.56, 800 and 25 micrograms/ml, whereas those of ccl were 1.56, 800 and 100 micrograms/ml, respectively. the addition of a subinhibitory concentrati ... | 1991 | 1864765 |
| adaptive modeling of the human rib cage in median sternotomy. | this paper describes a limited computer-analyzed kinematic model of the rib cage that can be adapted to individual subjects. also described is its validation and use in assessing the changes in chest wall shape after coronary artery bypass graft (cabg) surgery in 12 patients. the positions of a small number of anatomic locations on the thoracic spine, ribs, manubrium, and sternum are measured from lateral and posterior-anterior chest radiographs. the computer program puts these two views togethe ... | 1991 | 1864807 |
| [free interpretations of facts on the hiv epidemic among drug addicts]. | | 1991 | 1865715 |
| experience with calcium antagonists nitrendipine, diltiazem, and verapamil and beta 2-agonist salbutamol in salvaging ischemic skin flaps in rabbits. | this study investigated the efficacy of selected agents in the salvage of experimental skin flaps in rabbits after 21 hours of 25 degrees c ischemia. calcium channel antagonists nitrendipine, diltiazem, and verapamil increased ischemic skin flap survival in rabbits from 33.3% for buffered saline infused controls to 71.4% (p less than 0.05), 71.4% (p less than 0.05), and 50.0% (not significant) respectively. the beta 2-adrenoceptor agonist salbutamol produced an increase in survival to 64.3%, whi ... | 1991 | 1865808 |
| comparative efficacies of soft contact lens disinfectant solutions against microbial films in lens cases. | biofilms of pseudomonas aeruginosa, serratia marcescens, staphylococcus epidermidis, streptococcus pyogenes, and candida albicans, established in the wells of a polyethylene contact lens case, retained viability to certain soft contact lens disinfectant solutions after exposure for the manufacturer's minimum recommended disinfection times. the relative order of resistance of bacterial biofilms was as follows: s marcescens was greater than p aeruginosa, which was greater than s epidermidis, which ... | 1991 | 1867561 |
| inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits. | we studied the inhibitory effects of chicken egg-white ovomacroglobulin (ovom) on keratitis induced by 56,000-da protease (56 kp) of serratia marcescens and by elastase (pe) and alkaline protease (pap) of pseudomonas aeruginosa. the effects of ovom on the serratial and pseudomonal keratitis in rabbits were also elucidated. in one model, four drops of 56 kp, pe, or pap (1 mg/ml) were applied to wounded corneas of eight eyes. thereafter, 80 microliters ovom (10 mg/ml) was dropped into four eyes an ... | 1991 | 1869068 |
| in vitro activity of an oxycephem ocp 9-176 compared with its sulfur analog and other beta-lactams. | ocp 9-176 is an oxycephem antibiotic that contains a 2-aminothiazolyl, carboxypropyl side chain at c-7 and a pyridinium thiomethyl group at c-3. ocp 9-176 was generally twofold less active than its sulfur-containing analog me 1228 against escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, providencia stuartii, proteus vulgaris, and serratia marcescens. activity against enterobacter cloacae and citrobacter freundii was equivalent. ocp 9-176 was twofold less active than me-1228 against p ... | 1991 | 1873972 |
| adherence of serratia marcescens in the pathogenesis of urinary tract infections in diabetic mice. | the adherence of serratia marcescens to bladder epithelial cells of mice with alloxan-induced diabetes was studied. s. marcescens adhered more strongly to the bladder epithelial cells of diabetic mice than to those of normal mice both in vitro and in vivo. the susceptibility of diabetic mice to urinary tract infection may be due to an increased adhesive capacity of bladder epithelial cells. | 1991 | 1875397 |
| [combined antibacterial activity of aztreonam and clindamycin against clinically isolated strains]. | it has been reported in some studies that the combination of aztreonam (azt) and clindamycin (cldm) have high clinical effectiveness in the treatment of intractable infections. we, therefore, studied combined in vitro antibacterial activity of these 2 compounds using many freshly isolated strains. 1. azt and cldm in combination had synergistic effects on staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, and haemophilus influenzae, which are sensitive or quasi-sensitive ... | 1991 | 1880932 |
| plasmid mediated ceftazidime resistance identified in a strain of serratia marcescens isolated in belgium. | | 1991 | 1885428 |
| combination effect of sce-2787 and cefepime with aminoglycosides on nosocomial gram-negative bacteria. | the in vitro activity of cefepime and sce-2787, two new parenteral cephalosporins, and the combination effect with tobramycin and gentamicin against nosocomial gram-negative rods was studied using checkerboard agar dilution technique. cefepime showed excellent in-vitro activity against klebsiella pneumoniae, enterobacter cloacae, serratia marcescens and proteus vulgaris (mic90 0.03-0.125 mg/l) and good to moderate activity against acinetobacter anitratus, pseudomonas aeruginosa and pseudomonas c ... | 1991 | 1889877 |
| serratia marcescens meningitis. | a case of serratia marcescens meningitis in a 66-year-old man is reported. the infection occurred 4 weeks after apparently successful otic surgery, and a nidus of infection in the middle ear was established at autopsy. this is the second case of s. marcescens meningitis following ear surgery reported in the english-language literature. | 1991 | 1890185 |
| community- and hospital-acquired respiratory syncytial virus infections in chile. | nasopharyngeal aspirates were obtained on admission from 614 patients younger than 2 years of age who were hospitalized in a ward for acute respiratory infections from june 1988 through october, 1989, in santiago, chile. patients in two rooms were followed during the cold seasons by sampling aspirates every other day during the child's entire hospital stay. clinical features were recorded daily. indirect monoclonal immunofluorescent assay and isolation in hep-2 were used for respiratory syncytia ... | 1991 | 1891287 |
| association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution. | in order to direct antisense oligonucleotides to specific tissues or cell types in vivo, we are exploring the possibility to utilize lipoproteins as transport vehicles. a 16-mer oligonucleotide (odn) was derivatized at the 5' prime through a 32p phosphate spacer with cholesterol, yielding a 32p-labeled amphiphatic cholesteryl-oligonucleotide (cholodn). incubation of cholodn with low-density lipoprotein (ldl) for 2 hr at 37 degrees c resulted in the formation of a cholodn-ldl complex that migrate ... | 1991 | 1891360 |
| d-value determinations are an inappropriate measure of disinfecting activity of common contact lens disinfecting solutions. | determination of a d value for specific test organisms is a component of the efficacy evaluation of new contact lens disinfecting solutions. this parameter is commonly defined as the time required for the number of surviving microorganisms to decrease 1 logarithmic unit. the assumption made in establishing a d value is that the rate of kill exhibits first-order kinetics under the specified conditions. such exponential kill rates are seen with thermal contact lens disinfection system. a compariso ... | 1991 | 1892391 |
| disinfecting activities of non-peroxide soft contact lens cold disinfection solutions. | the antimicrobial activities of three non-peroxide soft contact lens chemical disinfection systems--renu multi-purpose solution (0.00005% polyaminopropyl biguanide), opti-soft disinfecting solution (0.001% polyquaternium-1), and opti-free rinsing, disinfecting & storage solution (0.001% polyquaternium-1)--were compared to soft mate disinfecting solution (0.005% chlorhexidine digluconate). each product was separately inoculated with each of five microorganisms at approximately 10(6) microorganism ... | 1991 | 1893538 |
| serratia species isolated from bovine intramammary infections. | intramammary infections from which serratia spp. were isolated were studied over a 32-mo period in a research dairy herd consisting of approximately 120 lactating cows. a total of 29 serratia spp. intramammary infections were detected and accounted for 9% of all gram-negative bacterial intramammary infections. serratia marcescens was the most common serratia spp. isolated. origin of intramammary infections was 48.3% during the first half of the dry period, 31% during the last half of the dry per ... | 1991 | 1894795 |
| altered organ growth and zinc and copper distribution in endotoxin-treated neonatal mice. | organ weights and the distribution of zinc and copper were compared in hla/icr mice that received intraperitoneal injections of 10 micrograms of serratia marcescens lipopolysaccharide w or of sterile physiologic saline at 2 d of age. between 5 and 28 d of age, body weight gains were similar in both groups. at 5 and 7 d of age, lipopolysaccharide w-treated mice had significantly lower thymus weights (p less than 0.01). at 7 d of age, liver weight was significantly increased (p less than 0.01) in ... | 1991 | 1896259 |
| persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-a2 activity via stimulation of 5-lipoxygenase. | human recombinant interleukin-1 beta (hril-1 beta) potentiated cacl2-induced contractions of isolated stomach strip preparations from adrenalectomized rats (adxss). associated with this effect were increased prostaglandin e2 and peptidyl leukotriene (lt) synthesis. unlike preparations from normal rat stomach strips or sham-operated animals, tissue responses and eicosanoid production of adxss failed to return to pre-hril-1 beta control levels after washout of the interleukin, these effects being ... | 1991 | 1899119 |
| monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins. | monoclonal antibodies against partially purified adenylyl cyclase from bovine brain cortex were raised in mice. three types of antibody were obtained. type 1 was specific for the calmodulin-sensitive enzyme. type ii also recognized this enzyme, but recognized the calmodulin-insensitive enzymes from a variety of species and tissues as well. type i antibodies precipitated their antigens in both the native and denatured forms, while type ii strongly favored the denatured forms. type iii antibodies ... | 1991 | 1899384 |
| monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins. | monoclonal antibodies against partially purified adenylyl cyclase from bovine brain cortex were raised in mice. three types of antibody were obtained. type 1 was specific for the calmodulin-sensitive enzyme. type ii also recognized this enzyme, but recognized the calmodulin-insensitive enzymes from a variety of species and tissues as well. type i antibodies precipitated their antigens in both the native and denatured forms, while type ii strongly favored the denatured forms. type iii antibodies ... | 1991 | 1899384 |
| effect of diabetes and aging on carboxymethyllysine levels in human urine. | carboxymethyllysine (cml) has been identified as a modified amino acid that accumulates with age in human lens proteins and collagen. cml may be formed by oxidation of fructoselysine (fl), the amadori adduct formed on nonenzymatic glycosylation of lysine residues in protein, or by reaction of ascorbate with protein under autoxidizing conditions. we proposed that measurements of tissue and urinary cml may be useful as indices of oxidative stress or damage to proteins in vivo. to determine the ext ... | 1991 | 1899406 |
| insect immune response to bacterial infection is mediated by eicosanoids. | inhibition of eicosanoid formation in larvae of the tobacco hornworm manduca sexta, using specific inhibitors of phospholipase a2, cyclooxygenase, and lipoxygenase, severely weakened the ability of larvae to clear the bacterium serratia marscescens from their hemolymph. the reduced capability to remove bacteria is associated with increased mortality due to these bacteria. there is a dose-dependent relationship between the phospholipase a2 inhibitor dexamethasone and both the reduced bacterial cl ... | 1991 | 1899480 |
| viability and distribution of bacteria after passage through a circle anaesthetic system. | we have assessed in vitro the viability of eight species of micro-organism suspended as aerosols and passed through a soda-lime absorber rebreathing system. as had been predicted, the soda-lime exerted a potent cidal effect on non-sporing organisms, all of which were rendered non-viable. one percent of the spore bearing organism, bacillus subtilis, was still viable after 30 min contact. although bacillus subtilis is an organism of low pathogenicity, spores may be more resistant to the alkaline m ... | 1991 | 1901723 |
| [combination antibacterial effects between aztreonam and eight other antibiotics]. | in vitro interactions between aztreonam (azt) and 8 other antibiotics were studied using the agar dilution checkerboard technique against 88 clinical isolates of escherichia coli, proteus vulgaris, serratia marcescens and pseudomonas aeruginosa. combinations of azt with 8 other antibiotics were generally additive or indifferent. synergism was occasionally seen against s. marcescens or p. aeruginosa with azt plus isepamicin (isp). antagonism was observed only between azt and latamoxef against p. ... | 1991 | 1904106 |
| in vitro and in vivo evaluation of ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. | ro 09-1428, a new parenteral cephalosporin with a catechol moiety attached at position 7 of the cephalosporin ring, showed high in vitro activity against escherichia coli, klebsiella pneumoniae, proteus mirabilis, proteus vulgaris, and streptococcus pyogenes, with mics for 90% of strains tested (mic90s) of less than or equal to 0.39 micrograms/ml. morganella morganii, providencia rettgeri, citrobacter freundii, haemophilus influenzae, staphylococcus aureus, and streptococcus pneumoniae were inhi ... | 1991 | 1906261 |
| efficacy of once- and thrice-daily dosing of aminoglycosides in in-vitro models of infection. | the bactericidal efficacy of amikacin, isepamicin and netilmicin was studied against pseudomonas aeruginosa and serratia marcescens over a treatment period of 30 h using two one-compartment in-vitro models with differently designed culture compartments. high bacterial inocula were exposed to fluctuating drug concentrations, simulating human serum concentrations (t1/2 = 2 h) during clinical treatment. the same daily dose was administered as 1 h infusions given every 8 h or every 24 h, resulting i ... | 1991 | 1906863 |
| renal blood flow response to angiotensin ii infusions in conscious pregnant rabbits. | renal blood flow (rbf) was measured in conscious rabbits while nonpregnant and during pregnancy using chronically implanted ultrasonic transit-time flow probes. the effects of the cyclooxygenase inhibitor meclofenamate (5 mg/kg) and the angiotensin-converting-enzyme inhibitor captopril (5 mg/kg) on basal rbf and on rbf responses to systemic angiotensin ii infusions (2.5-80 ng.kg-1.min-1) were determined. basal rbf declined (p less than 0.001 to p less than 0.005) with meclofenamate by 9-16% in p ... | 1991 | 1907106 |
| formaldehyde-resistance in enterobacteriaceae and pseudomonas aeruginosa: identification of resistance genes by dna-hybridization. | a 4.1. kb large dna fragment of a e. coli plasmid pvu 3695, on which the genes for formaldehyde-resistance are located, was used as a dna probe to identify bacteria that carry this segment among formaldehyde-resistant bacteria. it was shown by southern blot-, dot blot-, and colony blot- hybridization studies that the dna of all formaldehyde-resistant e. coli, serratia marcescens, enterobacter cloacae, citrobacter freundii and klebsiella pneumoniae strains tested hybridize with the dna probe from ... | 1991 | 1909132 |
| in vitro antimicrobial activity of sparfloxacin (at-4140, ci-978, pd 131501) compared with numerous other quinolone compounds. | sparfloxacin (at-4140, ci-978, pd 131501) was tested against over 800 recent bacteremic strains and compared with ciprofloxacin and six other fluoroquinolones. the 90% minimum inhibitory concentration (mic90) ranges for the enterobacteriaceae species were (a) sparfloxacin, 0.03-1 microgram/ml and (b) ciprofloxacin, 0.015-0.25 microgram/ml. moraxella catarrhalis, haemophilus influenzae, and neisseria gonorrhoeae were very susceptible to sparfloxacin (mic90s, 0.004- less than or equal to 0.03 micr ... | 1991 | 1909615 |
| human platelet-specific antigen, siba, is associated with the molecular weight polymorphism of glycoprotein ib alpha. | platelet-specific antigen sib(a) has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (hla)-matched platelet transfusions in japan. we provide evidence that the sib(a) antigen is located on the glycoprotein (gp) ib alpha and has a close association with the molecular weight (mol wt) polymorphism of gpib. in modified antigen-capture elisa (mace), anti-sib(a) antibody reacted only with gpib/ix held by a murine anti-gpib/ix monoclonal antibody (moab). the reac ... | 1991 | 1912562 |
| [synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-ht1b and 5-ht1d binding sites of the central nervous system]. | we describe here the synthesis of a new serotonin conjugate, s-cm-gtnh2, and its radioiodinated derivative. quantitative autoradiographic studies on rat and guinea pig brain sections incubated with 2 nm [3h]5-ht showed a preferential affinity of s-cm-gtnh2 for 5-ht1b and 5-ht1d sites. autoradiograms from brain sections incubated with 0.02 nm s-cm-g[125i]tnh2 showed a heterogeneous anatomical distribution of the labelling with high densities in regions rich in 5-ht1b or 5-ht1d binding sites, and ... | 1991 | 1913239 |
| [functional inactivation of centrosome of mouse 3t3 cells by heat shock]. | the microtubule assembly capacity of centrosome has been tested in mouse 3t3 cells. following heat shock (30 min. at 43.5 degrees c), centrosomes display a total lack of microtubule nucleation. this stress leads to functional arrest of the organelle. the natural control of the activity of the centrosome is therefore questionable. | 1991 | 1913241 |
| biosynthesis of isochorismate in klebsiella pneumoniae: origin of o-2. | the shikimate metabolites are key precursors to a large number of natural products, including aromatic amino acids. chorismic acid is an important branch point in the biosynthetic pathway to aromatic amino acids. chorismic acid is also unique among natural products since it is the only compound known to undergo an enzymatic claisen rearrangement. a metabolite of chorismic acid, isochorismic acid, first observed in aerobacter aerogenes differs in its chemical structure by the location of the hydr ... | 1991 | 1913340 |
| competition between strains of escherichia coli with and without plasmid rp4 during chemostat growth. | escherichia coli strains j53(nal) and j53(rp4) were grown together in glucose-limited continuous cultures. based on the measured growth kinetic constants of the two strains, take-over of the cultures by j53(rp4) was predicted. however, in practice, an initial period of predominance by j53(rp4) was always followed by a prolonged period in which relative numerical proportions of the two strains oscillated widely. this period of oscillation was removed or greatly reduced when the difference between ... | 1991 | 1913355 |
| primary lymphoma of the heart. prolonged survival with early systemic therapy in a patient. | primary lymphoma of the heart is an uncommon malignancy usually recognized at autopsy or fatal within a few weeks of diagnosis. recently, it was reported in patients with acquired immune deficiency syndrome. a patient with diffuse large cell lymphoma of the heart is reported who had chest pain and rapidly evolving cardiac arrhythmias. the human immune deficiency virus antibody test was negative. because of an aggressive diagnostic approach, therapy with cyclophosphamide, doxorubicin, vincristine ... | 1991 | 1913464 |
| [a case of adrenomyeloneuropathy with marked spinal cord atrophy on magnetic resonance imaging]. | a 29-year-old man complained of increasing paraplegia and sphincter disturbances. on admission, he was 23 years old. he had moderate pigmentation of the skin, and his neurological examinations revealed spastic paraplegia, hyperreflexia of both legs with babinski's signs, a pinprick sensation deficit below the l-1 level, loss of vibration sense in the lower extremities and horizontal nystagmus on lateral gaze. endocrinological examinations revealed adrenocortical insufficiency. csf, eeg, emg, bra ... | 1991 | 1914336 |
| in vitro activity of cefpodoxime against bacterial isolates obtained from patients with cancer. | the in vitro activity of cefpodoxime, an oral cephalosporin ester, against 792 bacterial isolates representing 36 species was evaluated in comparison to that of ciprofloxacin and trimethoprim/sulfamethoxazole (tmp/smx). cefpodoxime inhibited the majority of streptococcus spp., haemophilus influenzae and proteus mirabilis at a concentration of less than or equal to 0.12 microgram/ml. it was also active against citrobacter diversus, escherichia coli, klebsiella spp., proteus vulgaris, serratia mar ... | 1991 | 1915401 |
| unusual aminoglycoside susceptibility pattern and mechanisms of resistance of serratia marcescens strains from italy. | | 1991 | 1917041 |
| rufloxacin once daily in acute exacerbations of chronic bronchitis. | in this open study the efficacy and tolerability of rufloxacin in a single dose of 400 mg the first day and 200 mg the nine consecutive days was studied in 26 patients with an acute exacerbation of chronic bronchitis. twenty-two patients were evaluable for efficacy. four patients stopped treatment prematurely after five days because of clinical cure. at the enrollment visit a pathogen was isolated in the sputum sample in 19 of 22 evaluable patients. the predominant pathogens were streptococcus p ... | 1991 | 1917050 |
| genes coding for integration host factor are conserved in gram-negative bacteria. | a genetic system for the selection of clones coding for integration host factor and hu homologs is described. we demonstrate that the hima and hip genes of serratia marcescens and aeromonas proteolytica can substitute for the escherichia coli genes in a variety of biological assays. we find that the sequence and genetic organization of the hima and hip genes of s. marcescens are highly conserved. | 1991 | 1917861 |
| erwinia carotovora subsp. carotovora extracellular protease: characterization and nucleotide sequence of the gene. | the prt1 gene encoding extracellular protease from erwinia carotovora subsp. carotovora ec14 in cosmid pca7 was subcloned to create plasmid psk1. the partial nucleotide sequence of the insert in psk1 (1,878 bp) revealed a 1,041-bp open reading frame (orf1) that correlated with protease activity in deletion mutants. orf1 encodes a polypeptide of 347 amino acids with a calculated molecular mass of 38,826 da. escherichia coli transformed with psk1 or psk23, a subclone of psk1, produces a protease ( ... | 1991 | 1917878 |
| serratia cellulitis and secondary infection of leg ulcers by serratia. | | 1991 | 1918497 |
| genetic studies of the ends of a locked-in kappa prophage in serratia marcescens by transductional and vegetative crosses. | in temperate phage kappa of serratia marcescens several special features of different phages are combined. the unessential genes li, iny, cii and, at least to some extent, even the integrase gene int are not subject to negative control by the repressor, the product of gene ciii. a genetic map of the prophage was established using defective, heat-induced lysates of int- lysogens both in vegetative crosses with sus mutants of essential genes and in transduction of the four unessential genes to lys ... | 1991 | 1920083 |
| university of north carolina caries risk assessment study. iii. multiple factors in caries prevalence. | the baseline caries experienced of approximately 5,000 children in south carolina and maine was used as the dependent variable in caries risk assessment analyses. clinical, microbiologic, and demographic factors served as independent variables in a multivariate relationship to caries through regression and discriminant function analyses. four factors--number of dental visits by the child in the past year, presence of white spot lesions, and both the urgency of need for restorative care and the f ... | 1991 | 1920265 |
| [clinical evaluation of imipenem/cilastatin sodium in the internal medicine]. | fifty-two patients with moderate or severe infections associated with internal medicine were treated with imipenem/cilastatin sodium (ipm/cs) and the efficacy and the safety of this drug were evaluated. there were 20 patients with pneumonia, 10 with acute exacerbation of chronic respiratory tract infections, 9 with sepsis, 2 with pyothorax, 3 with intraabdominal infection, 2 with urinary tract infection, 1 with pulmonary abscess, 1 with infective endocarditis, 4 with fever of unknown origin. for ... | 1991 | 1920813 |
| serratia infections in patients with neutropenia. | we report on six cases of sepsis caused by serratia marcescens in patients with neutropenia. four cases showed an additional involvement of the upper respiratory and digestive tract with oral and pharyngeal mucositis, haemorrhagic laryngo-tracheo-bronchitis, and oedematous swelling of the face. one patient showed a serratia marcescens carrier state in the pharynx over a period of months without neutropenia. the isolated strains showed a broad spectrum of resistance against antibiotics; only aztr ... | 1991 | 1921232 |
| serratia marcescens surgical wound infection following breast reconstruction. | surgical wound infections due to gram-negative bacilli have been rarely reported following breast implant surgery. from april to november 1989, four patients from one plastic surgeon's practice developed serratia marcescens surgical wound infection (swi) following breast reconstruction procedures with implantation of six expandable mammary implants. all six implants were removed for unabated s. marcescens swi. symptoms developed 13-161 days (median, 66 days) after surgery. when compared with non ... | 1991 | 1928161 |
| significance of inducible cephalosporinase remaining in the experimentally infected rat granuloma pouch after beta-lactam therapy. | we studied the influence of inducible cephalosporinase on levels of secondarily administered beta-lactam antibiotics in exudates using experimentally infected rat granuloma pouches. cefoperazone or cefmetazole was administered intramuscularly at a dose of 100 mg/kg of body weight to rats at 2 and 8 h after infection of rat pouches with serratia marcescens w-24, which possesses an inducible type i beta-lactamase (cephalosporinase). subsequently, cefotaxime or cefbuperazone was administered at an ... | 1991 | 1929254 |
| influence of beta-lactamase inhibitors on the potency of their companion drug with organisms possessing class i enzymes. | the ability of beta-lactamase inhibitors to induce class i beta-lactamases in certain organisms in vitro suggests a potential for antagonism in vivo. therefore, a study was designed to assess the ability of sulbactam and clavulanate to induce beta-lactamases in two strains each of enterobacter cloacae, citrobacter freundii, serratia marcescens, and pseudomonas aeruginosa both in vitro and in vivo. induction in vitro was observed only with s. marcescens and p. aeruginosa and generally only when i ... | 1991 | 1929291 |
| l-prolineaminopeptidase activity as a tool for identification and differentiation of serratia marcescens, serratia liquefaciens and hafnia alvei strains. | s. marcescens (316 strains), s. liquefaciens (10 strains) and hafnia alvei (20 strains), in contrast to 18 other enterobacteriaceae species, hydrolyzed l-proline-4-nitroanilide within 30 min at 37 degrees c. in this way, rapid identification of these species is possible. the substrate is applied in solution or in a paper disc. the substrate optimum of hafnia alvei strains proved to be 16 times lower than that of the serratia spp. application of a tenth of the substrate concentration necessary fo ... | 1991 | 1930558 |
| the gene for the alpha 4 subunit of the vla-4 integrin maps to chromosome 2q31-32. | the vla-4 integrin (cd49d/cd29), initially discovered on lymphoid cells, is actually known to be highly expressed on t cells, b cells, monocytes, and derived cell lines. unlike other vla integrins, mainly involved in cell-matrix adhesive interactions, vla-4 has also been implicated in several cellular interactions. based on the published alpha 4 cdna sequence, a 1,142-bp alpha 4 cdna fragment was amplified using the polymerase chain reaction. this fragment was used to isolate three overlapping g ... | 1991 | 1932750 |
| changes over time in heroin and cocaine use among injecting drug users in amsterdam, the netherlands, 1985-1989. | three hundred and eighty six injecting drug users entered into an hiv study through methadone programs over a 40 month period. differences in oral, intranasal and parenteral use of heroin and cocaine were assessed between four consecutive 10 month intake groups. heroin smoking and cocaine freebasing were increased in the later intake groups, while there were no significant changes in injecting variables. no relationship between sexual risk behaviour and cocaine freebasing was found. hiv seroposi ... | 1991 | 1932880 |
| ultrasound-guided aspiration of a neonatal brain abscess. | the authors successfully treated a serratia marcescens brain abscess in the right parieto-occipital region of a newborn infant born at 27 weeks' gestation and weighing 800 g. bedside ultrasound-guided aspiration techniques and local anesthesia were used to treat the abscess. | 1991 | 1933928 |
| complete amino acid sequence of endo-beta-n-acetylglucosaminidase from flavobacterium sp. | the complete amino acid sequence of endo-beta-n-acetylglucosaminidase from flavobacterium sp. has been determined by analysis of peptides after cleavage with lysyl endopeptidase, pepsin and chymotrypsin. the protein consists of a single polypeptide chain consisting of 267 amino acid residues and a molecular mass of 27972 da. the sequence of flavobacterium endo-beta-n-acetylglucosaminidase is very close to that of the streptomyces enzyme (endo-h), having 60% similarity and very similar hydropathy ... | 1991 | 1935974 |
| factors affecting duration of in-vivo postantibiotic effect for aminoglycosides against gram-negative bacilli. | a murine thigh-infection model was used to determine the effect of certain host- and drug-related factors on the duration of the in-vivo postantibiotic effect (pae) observed with aminoglycosides against gram-negative bacilli. the role of neutrophils (pmns), pharmacokinetics and variation among species and strains were studied. paes were quantitated after a single injection of gentamicin or amikacin. paes were several hours longer in normal mice than in neutropenic mice, in mice with renal impair ... | 1991 | 1938689 |
| in vitro activity of chlorhexidine against enteric rods, pseudomonads and acinetobacter from human periodontitis. | fifty-eight periodontal isolates of the families enterobacteriaceae and pseudomonadaceae, and the genera acinetobacter and achromobacter were studied to determine their susceptibility to peridex (0.12% chlorhexidine digluconate solution; procter & gamble). in an agar dilution assay, about 50% of the study strains grew in the presence of 70 micrograms/ml of chlorhexidine. enterobacter cloacae, klebsiella pneumoniae, pseudomonas aeruginosa, pseudomonas cepacia, and serratia marcescens comprised th ... | 1991 | 1945483 |
| epidemiological picture of respiratory viral infections in croatia. | this paper presents the epidemiological study of respiratory viral infections in croatia from 1 september 1986 till 31 august 1987. a total of 527 patients with acute respiratory diseases were examined. their nasopharyngeal secretion and/or throat swab were taken and the viruses were demonstrated by the method of direct viral diagnosis (isolation and rapid immunofluorescent detection). this 12-month study on acute respiratory infections in croatia in 1986/1987 shows that viruses were the agents ... | 1991 | 1950639 |
| orphan drug for hiv wasting syndrome. | | 1991 | 1950976 |
| [a case of delayed mediastinitis after coronary bypass grafting]. | we experienced a case of delayed mediastinitis, who had coronary bypass surgery using saphenous vein graft fifteen months before. at that time, a gore-tex pericardial sheet had been used for protection from adhesion. persistent discharge from unhealed small fistula, which appeared at ten months after surgery, gave notice of mediastinitis. it was supposed that complicated diabetes mellitus might be causative of this infection. a bacterial examination detected serratia marcescence and a fistulogra ... | 1991 | 1956145 |
| ultrastructural features of the serotonin innervation in adult rat hippocampus: an immunocytochemical description in single and serial thin sections. | this study was aimed at characterizing the fine-structural features of the normal serotonin (5-ht) innervation in adult rat hippocampus, by means of electron microscopic immunocytochemistry with a polyclonal antiserum against 5-ht-glutaraldehyde-protein conjugate (donated by michel geffard, bordeaux). two hippocampal sectors were examined, at mid-level along the septo-temporal axis: ca3-a of ammon's horn and crest of the dentate gyrus (dg-c). a large number of axonal varicosities (terminals) wer ... | 1991 | 1956515 |
| structure of a mannan isolated from the lipopolysaccharide of the reference strain (s3255) for a new serogroup of serratia marcescens. | both a neutral and an acidic polymer have been isolated from a lipopolysaccharide extract of serratia marcescens strain s3255. the neutral polymer is a linear mannan with the repeating unit shown. the same repeating unit has been described for the o-specific polymers from escherichia coli o8 and klebsiella o5. | 1991 | 1959117 |
| characterization of two aminoglycoside-(3)-n-acetyltransferase genes and assay as epidemiological probes. | two genes encoding for aminoglycoside-(3)-n-acetyltransferases (aac(3)s) of different substrate patterns, present in multiresistance plasmids of hospital strains of serratia marcescens and escherichia coli isolated from urine, have been cloned and characterized. the first, aacc1 with aac(3)i activity, contained a 531 base pair open reading frame which encodes a polypeptide of 177 aminoacids and 19,392 daltons, confirmed by minicell analysis. its sequence differed from previously published work i ... | 1991 | 1960117 |
| characterization of fce 22101-resistant enterobacteriaceae and the effect of fce 22101 upon the activity of anti-pseudomonal beta-lactams for pseudomonas aeruginosa. | twenty-five strains of enterobacteriaceae (five each of enterobacter cloacae, citrobacter freundii, serratia marcescens, morganella morganii, and providencia stuartii) were exposed to fce 22101 in agar containing 3, 5, or 10 x the mic. any putative mutant with a greater than or equal to four-fold increase in the mic was examined for beta-lactamase expression and outer membrane protein (omp) profile. mutant colonies were selected at a frequency of 10(-7)-10(-11) with decreased susceptibility to f ... | 1991 | 1960118 |
| [antibacterial activities of ofloxacin against recent isolates from patients with community-acquired infections]. | in order to survey antibacterial activities of ofloxacin (oflx) against 1,440 bacterial strains isolated from patients with community-acquired infections in 1987 and 1990, minimum inhibitory concentrations (mics) of the drug as well as those of other new quinolones and oral cephems were determined. the following conclusions were reached. 1. comparison of the mic distribution for strains isolated in 1987 with those in 1990 suggested a tendency toward an increase in the frequency of oflx-resistant ... | 1991 | 1960856 |
| [intraocular penetration of dr-3355, a new quinolone derivative]. | we studied the intraocular penetration of dr-3355, a new quinolone derivative in white mature rabbits. dr-3355 concentration in the aqueous humor reached the maximum, 1.06 micrograms/ml, at 2 hours after oral administration of 20 mg/kg in single dose. six hours after it was 0.37 micrograms/ml. at 2 hours, the concentration ratio in the aqueous humor and serum was 23.3%. the pharmacokinetic parameters of dr-3355 levels in both of the aqueous humor and serum were: cmax, 1.02 micrograms/ml and 4.56 ... | 1991 | 1960857 |
| effects of protease inhibitors on growth of serratia marcescens and pseudomonas aeruginosa. | the growth inhibitory effects of chicken egg white ovomacroglobulin (ovom) on serratia marcescens and pseudomonas aeruginosa were studied. the growth of protease-producing strains was greater than that of the strains producing little protease, and was inhibited in a dose-dependent manner by ovom, a potent protease inhibitor. dose-dependent enhancement of growth of strains of s. marcescens and p. aeruginosa that produce little protease was observed with the medium treated with proteases. these re ... | 1991 | 1961110 |
| [infection with serratia marcescens in newborn infants. clinical aspects, therapy and disease course]. | until the 1950's serratia marcescens was generally considered as non-pathogenic for humans. since then the organism has been reported repeatedly as a cause of nosocomial infections. the major clinical concern about serratia marcescens is its implication in epidemic infections and its resistance to usual antibiotics causing therapy to be difficult. we report the occurrence of serratia marcescens as the cause of severe septicemia in three premature infants. two infants showed a severe course of se ... | 1991 | 1961210 |
| [ascorbic acid radicals induced by the action of radiation in tissues from rat organs frozen at 77 k]. | subsequent annealing technique and computer assistant analysis of epr spectra were used to isolate an asymmetric epr signal rs(g = 2,0051; delta h = 0.8 mt) from the epr spectrum of rat spleen gamma-irradiated at 77 k. radicals with the same epr spectrum were registered in: 1) water solution of ascorbic acid (2.10(-2) m, ph 3.4) frozen and irradiated at 77 k and 2) water-glycerol solution of ascorbic acid (10(-2) m, ph 10.3) frozen rapidly at the moment of intensive autooxidation. these model ex ... | 1990 | 1963628 |
| [isolation of isoforms and crystallization of endonucleases of serratia marcescens]. | two isoforms of an extracellular endonuclease, nuclease sm1 and nuclease sm2, were isolated from the culture filtrate of serratia marcescens strain b10 m1 by the ligand-exchange chromatography on iminodiacetate-agarose in cu2(+)-form, and chromatography on phosphocellulose and deae-toyopearl 650s. the pi for nucleases sm1 and sm2 were found to be 7.1 and 6.7, respectively. the amino acid analysis and n-terminal amino acid sequencing of the proteins showed a significant degree of homology between ... | 1990 | 1965284 |
| cloning, expression, and sequence analysis of the haemophilus influenzae type b strain m43p+ pilin gene. | by using antiserum against haemophilus influenzae type b (hib) strain m43p+ denatured pilin, we screened a genomic library of hib strain m43p+ and identified a clone that expressed pilin, but not assembled pili, on its surface. southern blot analysis revealed the presence of one structural gene, which was also present in strain m42p-, a nonpiliated variant. five exonuclease iii deletion mutants, two of which had deletions that extended into the structural gene and failed to express pilin, were u ... | 1990 | 1969389 |
| nosocomial serratia marcescens individualized by five typing methods in a regional hospital. | the relationships between 69 isolates obtained from 26 patients who were affected by two serratia marcescens hospital outbreaks occurring in the urology and postnatal wards, were examined by five typing methods for epidemiological purposes. serotyping, antibiotic resistance profile and electrophoretic analysis of enzymes identified three groups of isolates, while biotyping and bacteriocin typing identified only two. these surveys allowed us to demonstrate the existence of independent episodes of ... | 1990 | 1969439 |
| hygienic hand disinfection: a comparative study with chlorhexidine detergents and soap. | the efficacy of two chlorhexidine hand-wash detergents and liquid soap was compared in a laboratory trial using artificial contamination of fingers with micrococcus and serratia. agents were assessed for both a rapid and sustained effect after a single contact, and for a cumulative persistent effect after multiple contact over four days. disinfectant activities were compared by statistical analysis of log reduction factors and log count time gradients (decimal reduction times). the latter analys ... | 1990 | 1972948 |
| fetal pulmonary vasodilation by histamine: response to h1 and h2 stimulation. | we measured pulmonary vasodilation induced by histamine, h1 and h2 antagonists, and h1 and h2 agonists in chronically prepared, normally oxygenated fetal sheep in order to study the response of h1 and h2 stimulation in late gestation. blood flow was measured in the left pulmonary artery; pressures were measured in the main pulmonary artery and abdominal aorta. histamine administered into the left pulmonary artery caused dose-dependent increases in left pulmonary blood flow without changes in eit ... | 1990 | 1973090 |
| suitability of colchicine and superoxide dismutase for the suppression of renal scarring following an infection with bacteria showing mannose-sensitive pili. | two new strains of serratia marcescens were constructed by the gene manipulation method from the clinical isolate us 46, which has two kinds of pili--mannose-sensitive (ms) and mannose-resistant (mr) ones--on the cell surface. after cloning the genes of the ms and mr pili, either the ms or the mr gene was transferred to the nonpiliated escherichia coli, and ms- or mr-piliated strains were obtained. in the experimental pyelonephritis model of rats, ms- or mr-piliated bacteria were inoculated dire ... | 1990 | 1978735 |
| increased renal scarring by bacteria with mannose-sensitive pili. | renal scars are thought to be the end stage of chronic pyelonephritis and one of the most important causes of renal insufficiency and renal hypertension. the role of bacterial pili was examined in scar formation after an infection of newly constructed bacterial strains using the recombinant dna technique, which possessed either mannose resistant (mr) or mannose sensitive (ms) pili of serratia marcescens. strains that differed in only a single virulence factor, namely, mr or ms pili, were used in ... | 1990 | 1979456 |
| structural studies of acidic polymers produced by the o23 reference strain of serratia marcescens: presence of amide-linked glutamic acid. | the major fraction of an acidic galactoglucomannan present in lipopolysaccharide extracts from cell walls of the o23 reference strain of serratia marcescens has the tetrasaccharide repeating-unit shown. in a minor fraction, l-glutamic acid was amide-linked to about half of the d-glucuronic acid residues. the possible contributions of the acidic polymers and a neutral polymer produced by the organism to cross-reactions with other serogroups are discussed. | 1990 | 1980630 |
| characterization of the type 1 fimbrial subunit gene (fima) of serratia marcescens. | the nucleotide sequence of a dna fragment that contains the fima gene, encoding the major fimbrial subunit, of serratia marcescens ia506 and associated flanking sequences has been elucidated. in addition, the origin of transcription has been identified and is located 120 base pairs upstream of the fima initiation codon. the predicted amino acid sequence of the fima polypeptide exhibits some degree of sequence homology with the fimbrial subunits encoded by the fima determinants of klebsiella pneu ... | 1990 | 1982455 |
| effect of prior cancer chemotherapy on human tumor-specific cytotoxicity in vitro in response to immunopotentiating biologic response modifiers. | tumor-specific cytotoxicity was measured in fresh human biopsy specimens by a modification of the differential staining cytotoxicity assay. imuvert, a cytokine inducer derived from serratia marcescens, which produces broad-spectrum activation of both macrophages and lymphocytes, was dramatically more effective when it was tested in tumors obtained from patients with previously treated, chemotherapy-responsive adenocarcinomas (breast and ovary) than when it was tested in tumors obtained from eith ... | 1991 | 1984515 |
| isolation and characterization of ilva, ilvbn, and ilvd mutants of caulobacter crescentus. | caulobacter crescentus strains requiring isoleucine and valine (ilv) for growth were shown by transduction and pulsed-field gel electrophoresis to contain mutations at one of two unlinked loci, ilvb and ilvd. other c. crescentus strains containing mutations at a third locus, ilva, required either isoleucine or methionine for growth. biochemical assays for threonine deaminase, acetohydroxyacid synthase, and dihydroxyacid dehydratase demonstrated that the ilva locus encodes threonine deaminase, th ... | 1991 | 1991719 |
| production and characterization of a monoclonal antibody specific for enterohemorrhagic escherichia coli of serotypes o157:h7 and o26:h11. | a monoclonal antibody (mab 4e8c12) specific for escherichia coli o157:h7 and o26:h11 was produced by immunizing balb/c mice with a rough strain of e. coli o157:h7. the antibody reacted strongly by a direct enzyme-linked immunosorbent assay with each of 36 strains of e. coli o157:h7. no cross-reactivity was observed with strains of salmonella spp., yersinia enterocolitica, shigella dysenteriae, proteus spp., escherichia hermanii, klebsiella pneumoniae, campylobacter jejuni, serratia marcescens, c ... | 1991 | 1993773 |
| immune mechanisms in experimental and essential hypertension. | | 1991 | 2000994 |
| cloning and expression in escherichia coli of the serratia marcescens metalloprotease gene: secretion of the protease from e. coli in the presence of the erwinia chrysanthemi protease secretion functions. | the serratia marcescens extracellular protease sm is secreted by a signal peptide-independent pathway. when the prtsm gene was cloned and expressed in escherichia coli, the cells did not secrete protease sm. the lack of secretion could be very efficiently complemented by the erwinia chrysanthemi protease b secretion apparatus constituted by the prtd, prte, and prtf proteins. as with protease b and alpha-hemolysin, the secretion signal was located within the last 80 amino acids of the protease. t ... | 1991 | 2007544 |
| mutations replacing the leucine codons or altering the length of the amino acid-coding portion of the ilvgmeda leader region of escherichia coli. | the specificity of regulation by attenuation of the ilvgmeda operon of escherichia coli was examined by making alterations in the peptide-coding portion of the leader region. the effects of the alterations on attenuation control were monitored by operon fusions with the lacz or cat gene. substitution of the tandem leucine codons with arginine codons did not result in arginine control of attenuation even though the altered leader transcripts contained three consecutive arginine codons. substituti ... | 1991 | 2007556 |
| killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils. | the susceptibility of opportunist pathogens associated with chronic granulomatous disease (cgd) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. the dose and ph-dependency of killing of aspergillus fumigatus, candida albicans, escherichia coli, nocardia asteroides, serratia marcescens and staphylococcus aureus differed markedly and may partly explain their virulence in cgd, in which oxygen-dependent killing mechani ... | 1991 | 2010902 |
| malaria parasite chitinase and penetration of the mosquito peritrophic membrane. | malaria parasites (ookinetes) appear to digest the peritrophic membrane in the mosquito midgut during penetration. previous studies demonstrated that lectins specific for n-acetylglucosamine bind to the peritrophic membrane and proposed that the membrane contains chitin [rudin, w. & hecker, h. (1989) parasitol. res. 75, 268-279]. in the present study, we show that the peritrophic membrane is digested by serratia marcescens chitinase (ec 3.2.1.14), leading to the release of n-acetylglucosamine an ... | 1991 | 2011589 |
| antimicrobial effects of the combination of ceftibuten and an orally absorbed penem sch 29482. | ceftibuten is a new beta-lactamase-stable 3-aminothiazolyl cephalosporin that lacks activity against staphylococci and group-b streptococci. we determined the effect of the combination of ceftibuten with sch 29482, an orally absorbed penem. the combination of the two agents was additive for 25% or indifferent for 57% of the gram-positive species, haemophilus, and moraxella tested with a mean fractional inhibitory concentration (fic) index of 0.75. the combination of ceftibuten and sch 29482 was ... | 1991 | 2013213 |
| ability of ceftibuten to induce the class-i beta-lactamases of enterobacter cloacae, serratia marcescens, and enterobacter aerogenes. | ceftibuten, like cefotaxime, was observed to be a weak inducer of the class-i beta-lactamases of enterobacter cloacae, serratia marcescens, and enterobacter aerogenes. in contrast, cefoxitin and imipenem induced these enzymes strongly at subinhibitory concentrations. | 1991 | 2013214 |
| impact of dosage schedule on the efficacy of gentamicin, tobramycin, or amikacin in an experimental model of serratia marcescens endocarditis: in vitro-in vivo correlation. | aminoglycosides are usually considered to be concentration-dependent antibiotics and to have similar pharmacodynamic and pharmacokinetic properties. to verify the equivalent activity of the aminoglycosides on a susceptible strain, we tested the killing rate of three aminoglycosides (gentamicin, tobramycin, and amikacin) on one strain of serratia marcescens both in vitro and in vivo by using a rabbit model of left-ventricle endocarditis. despite, similar mics, the time-kill curve of gentamicin wa ... | 1991 | 2014965 |