| screening nasal swabs for methicillin resistant staphylococcus aureus: a regional burn center's experience. | methicillin-resistant staphylococcus aureus (mrsa) is a pathogen that can result in substantial morbidity and mortality. early detection of mrsa colonization by screening nasal swabs may be important in the management of burn-injured patients. however, studies examining its use in this population are limited. the aim of this study was to study the utility of admission mrsa screening nasal swabs and determine if being positive for mrsa on admission impacted outcomes. | 2017 | 28412131 |
| effect of antimicrobial and physical treatments on growth of multispecies staphylococcal biofilms. | the prevalence and structure of staphylococcus aureus and staphylococcus epidermidis within multispecies biofilms were found to depend sensitively on physical environment and antibiotic dosage. although these species commonly infect similar sites, such as orthopedic implants, little is known about their behavior in multispecies communities, particularly in response to treatment. this research establishes that s. aureus is much more prevalent than s. epidermidis when simultaneously seeded and gro ... | 2017 | 28411222 |
| construction of a gene knockdown system based on catalytically inactive ("dead") cas9 (dcas9) in staphylococcus aureus. | there has been an absence of an efficient method of gene knockdown in the important human pathogen staphylococcus aureus like rna interference in eukaryotes. the previously developed antisense rna technology is mainly applied for forward genetic screening but is rather limited in specific gene knockdown because of the lack of rational antisense rna design strategies. here we report an efficient and specific system for gene knockdown in s. aureus based on the type ii clustered regularly interspac ... | 2017 | 28411216 |
| direct antimicrobial activity of ifn-β. | type i ifns are a cytokine family essential for antiviral defense. more recently, type i ifns were shown to be important during bacterial infections. in this article, we show that, in addition to known cytokine functions, ifn-β is antimicrobial. parts of the ifn-β molecular surface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobial peptides, and we observed that ifn-β can directly kill staphylococcus aureus further, a mutant s. aureus that is more se ... | 2017 | 28411186 |
| antibacterial efficacy of silver nanoparticles against multi-drug resistant clinical isolates from post-surgical wound infections. | in order to investigate new effective and inexpensive nano-therapeutic approach for p. aeruginosa, staphylococcus aureus and coagulase negative staphylococci (cons), the present study reports an eco-friendly process for rapid synthesis of silver nanoparticles (ag-nps) using aqueous leaf extract of corchorus capsularis (crcp). formation of stable ag-nps at different time intervals gives mostly spherical particles with diameters ranging from 5 to 45 nm. the resulting ag-nps were characterized usin ... | 2017 | 28411059 |
| wearing id badges in the operating room environment: is reconsideration warranted? | surgical site infection and nosocomial infections in general have appropriately undergone increased scrutiny over the last decade. numerous studies have documented pathogenic bacterial contamination of personal items such as cell phones, pagers, ties, and pens in the hospital setting. it is our understanding that joint commission on accreditation of healthcare organizations requires all personnel to wear an identification badge at all times, which includes the operating room environment. | 2017 | 28410834 |
| staphylococcus aureus surface contamination of mobile phones and presence of genetically identical strains on the hands of nursing personnel. | we investigated the genetic relatedness of staphylococcus aureus isolates recovered from mobile phones and palms and fingers of users. genetically identical isolates were detected from mobile phones and their user and multiple users, which is consistent with mobile phones serving as reservoirs of infection in the health care environment. these findings reinforce the need for hand hygiene prior to patient contact as the most effective intervention for preventing health care-associated infection. | 2017 | 28410827 |
| deconstructing the relative benefits of a universal glove and gown intervention on mrsa acquisition. | the 20-site benefits of universal glove and gown (bugg) study found that wearing gloves and gowns for all patient contacts in the intensive care unit (icu) reduced acquisition rates of meticillin-resistant staphylococcus aureus (mrsa). the relative importance of gloves and gowns as a barrier, improved hand hygiene, and reduced healthcare worker (hcw)-patient contact rates is unknown. | 2017 | 28410760 |
| accessory gene regulator (agr) functionality in staphylococcus aureus derived from lower respiratory tract infections. | characterization of staphylococcus aureus clinical isolates derived from lower respiratory tract infections (lrtis), and correlation between the functionality of the accessory gene regulator (agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome. | 2017 | 28410390 |
| ccr-2 neutralization augments murine fresh bmc activation by staphylococcus aureus via two distinct mechanisms: at the level of ros production and cytokine response. | ccr-2 signaling regulates recruitment of monocytes from the bone marrow into the bloodstream and then to sites of infection. we sought to determine whether ccl-2/ccr-2 signaling is involved in the killing of staphylococcus aureus by murine bone marrow cells (bmcs). the intermittent link of reactive oxygen species (ros)-nf-κb/p38-mapk-mediated ccl-2 production in ccr-2 signaling prompted us to determine whether neutralization of ccr-2 augments the response of murine fresh bmcs (fbmcs) after s. au ... | 2017 | 28409543 |
| hospital dissemination of tst-1-positive clonal complex 5 (cc5) methicillin-resistant staphylococcus aureus. | methicillin-resistant staphylococcus aureus (mrsa), is one of the most prevalent clinical pathogens isolated from hospital settings, and has increasingly identified in community settings. in china, the sccmeciii-st239 strains are disseminated in different geographic regions, accounting for >75% of all mrsa isolates in some national studies. here we characterized 150 non-duplicate mrsa isolates collected from february 2012 to may 2013 in a tertiary hospital in suzhou, eastern china, to explore th ... | 2017 | 28409124 |
| anti-bacterial and anti-biofilm evaluation of thiazolopyrimidinone derivatives targeting the histidine kinase yycg protein of staphylococcus epidermidis. | staphylococcus epidermidis is one of the most important opportunistic pathogens in nosocomial infections. the main pathogenicity associated with s. epidermidis involves the formation of biofilms on implanted medical devices, biofilms dramatically decrease the efficacy of conventional antibiotics and the host immune system. this emphasizes the urgent need for designing novel anti-staphylococcal biofilm agents. based on the findings that compound 5, targeting the histidine kinase domain of s. epid ... | 2017 | 28408903 |
| shape-dependent antibacterial effects of non-cytotoxic gold nanoparticles. | gold nanoparticles (aunps) of various shapes (including spheres, stars and flowers), with similar dimensions, were synthesized and evaluated for their antibacterial effects toward staphylococcus aureus, a bacterium responsible for numerous life-threatening infections worldwide. optical growth curve measurements and gompertz modeling showed significant aunp shape- and concentration-dependent decreases in bacterial growth with increases in bacterial growth lag time. to evaluate prospective use in ... | 2017 | 28408817 |
| draft genome sequences of two clinical methicillin-resistant staphylococcus aureus strains isolated from healthy children in brazil. | we report here the draft genome sequences of two community-associated methicillin-resistant staphylococcus aureus (ca-mrsa) strains, c18 and c80, isolated from healthy children from day care centers. to our knowledge, these are the first draft genome sequences of ca-mrsa st398/cc398/sccmecv and ca-mrsa st5/cc5/sccmeciva isolated from healthy children in brazil. | 2017 | 28408675 |
| draft genome sequence of methicillin-resistant staphylococcus aureus strain lc33 isolated from human breast milk. | here, we report the draft genome sequence of staphylococcus aureus strain lc33, isolated from human breast milk in brazil. this microorganism has been typed as st1/t127/sccmecv. to our knowledge, this is the first draft genome sequence of a methicillin-resistant s. aureus strain isolated from human breast milk. | 2017 | 28408673 |
| pharmacokinetics of linezolid during continuous hemodiafiltration: a case report. | the pharmacokinetics of linezolid clearance (cllzd) during continuous hemodiafiltration (chdf) has not been comprehensively analyzed. here, we examined cllzd by chdf in a patient with septic shock and disseminated intravascular coagulation due to methicillin-resistant staphylococcus aureus. the extraction ratio of lzd by chdf was 22.6%, and the protein-binding rate was 17.9% ± 7.7%. in addition, it was determined that the calculated total body clearance of lzd was 30.2 ml/min, plasma elimination ... | 2017 | 28408302 |
| prevalence of methicillin-resistant staphylococcus aureus (mrsa) infection and the molecular characteristics of mrsa bacteraemia over a two-year period in a tertiary teaching hospital in malaysia. | methicillin-resistant staphylococcus aureus (mrsa) is an established pathogen that causes hospital- and community-acquired infections worldwide. the prevalence rate of mrsa infections were reported to be the highest in asia. as there is limited epidemiological study being done in malaysia, this study aimed to determine the prevalence of mrsa infection and the molecular characteristics of mrsa bacteraemia. | 2017 | 28407796 |
| erratum to: antibiotic resistance and biofilm production among the strains of staphylococcus aureus isolated in a tertiary care hospital in nepal. | | 2017 | 28407762 |
| the expression of fibronectin is significantly suppressed in macrophages to exert a protective effect against staphylococcus aureus infection. | fibronectin (fn) plays a major role in the attachment of staphylococcus aureus to host cells by bridging staphylococcal fibronectin-binding proteins (fnbps) and cell-surface integrins. a previous study demonstrated that the phagocytosis of s. aureus by macrophages is enhanced in the presence of exogenous fn. we recently found that fnbps overexpression also enhances phagocytic activity. the effect of s. aureus infection on the expression of macrophage fn was investigated. | 2017 | 28407745 |
| staphylococcus sciuri bacteriophages double-convert for staphylokinase and phospholipase, mediate interspecies plasmid transduction, and package meca gene. | staphylococcus sciuri is a bacterial pathogen associated with infections in animals and humans, and represents a reservoir for the meca gene encoding methicillin-resistance in staphylococci. no s. sciuri siphophages were known. here the identification and characterization of two temperate s. sciuri phages from the siphoviridae family designated ϕ575 and ϕ879 are presented. the phages have icosahedral heads and flexible noncontractile tails that end with a tail spike. the genomes of the phages ar ... | 2017 | 28406168 |
| daptomycin-associated eosinophilic pneumonia with rechallenge: a case report
. | a case of daptomycin-associated acute eosinophilic pneumonia (aep) with positive rechallenge is reported. | 2017 | 28406091 |
| comparison of whole-genome sequencing methods for analysis of three methicillin-resistant staphylococcus aureus outbreaks. | whole-genome sequencing (wgs) can provide excellent resolution in global and local epidemiological investigations of staphylococcus aureus outbreaks. a variety of sequencing approaches and analytical tools have been used; it is not clear which is ideal. we compared two wgs strategies and two analytical approaches to the standard method of smai restriction digestion pulsed-field gel electrophoresis (pfge) for typing s. aureus forty-two s. aureus isolates from three outbreaks and 12 reference isol ... | 2017 | 28404677 |
| the effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by mrsa in rats. | to investigate the microbiological, inflammatory and oxidant effects of adjuvant ozone administration in experimental rat vascular graft infection model which has not been previously investigated. | 2017 | 28403346 |
| bacterial osteomyelitis or nonbacterial osteitis in children: a study involving the german surveillance unit for rare diseases in childhood. | although bacterial osteomyelitis (bo) is a commonly recognized diagnosis in pediatrics, it is often difficult to distinguish from nonbacterial osteitis (nbo). the goal of our study was to distinguish between the 2 disease entities and better define nbo. | 2017 | 28403046 |
| investigation of a staphylococcal food poisoning outbreak from a chantilly cream dessert, in umbria (italy). | on august 28, 2015, a staphylococcal food poisoning outbreak occurred in umbria, italy, affecting 24 of the 42 customers who had dinner at a local restaurant. about 3 h after ingesting a variety of foods, the customers manifested gastrointestinal symptoms. within 24 h of notification from the hospital emergency department, sanitary inspectors of the local public health unit performed an epidemiological investigation. a retrospective cohort study was conducted among the customers. food and enviro ... | 2017 | 28402712 |
| tight binding of heme to staphylococcus aureus isdg and isdi precludes design of a competitive inhibitor. | the micromolar equilibrium constants for heme dissociation from isdg and isdi reported in the literature call into question whether these enzymes are actually members of the iron-regulated surface determinant system of staphylococcus aureus, which harvests heme iron from a host during infection. in order to address this question, the heme dissociation constants for isdg and isdi were reevaluated using three approaches. the heme dissociation equilibrium constants were measured using a uv/vis abso ... | 2017 | 28401968 |
| vancomycin prophylaxis for total joint arthroplasty: incorrectly dosed and has a higher rate of periprosthetic infection than cefazolin. | in total joint arthroplasty (tja), vancomycin is used as perioperative antibiotic prophylaxis in patients with penicillin allergy or in patients colonized with methicillin-resistant staphylococcus aureus (mrsa). although vancomycin dosing should be weight-based (15 mg/kg), not all surgeons are aware of this; a fixed 1-g dose is instead frequently administered. | 2017 | 28401341 |
| metastatic endogenous endophthalmitis: a rare presentation with methicillin-resistant staphylococcus aureus prostatic abscess. | a 62-year-old male with the previous history of uncontrolled diabetes and hypertension on irregular treatment presented with a history of fever, dysuria, and urinary retention with progressive painful loss of vision over a period of 2 days. his eye examination showed hypopyon, and he was diagnosed to have rapidly progressive endogenous endophthalmitis. he was started on vancomycin and piperacillin-tazobactam empirically. his blood and urine cultures grew methicillin-resistant staphylococcus aure ... | 2017 | 28400691 |
| amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein a affect bond strength and fibronectin conformation. | the staphylococcus aureus cell surface contains cell wall-anchored proteins such as fibronectin-binding protein a (fnbpa) that bind to host ligands (e.g. fibronectin; fn) present in the extracellular matrix of tissue or coatings on cardiac implants. recent clinical studies have found a correlation between cardiovascular infections caused by s. aureus and nonsynonymous snps in fnbpa. atomic force microscopy (afm), surface plasmon resonance (spr), and molecular simulations were used to investigate ... | 2017 | 28400484 |
| derepression of sapibov1 is independent of φnm1 type 2 dutpase activity and is inhibited by dutp and dump. | staphylococcus aureus is an opportunistic human pathogen able to transfer virulence genes to other cells through the mobilization of s. aureus pathogenicity islands (sapis). sapis are derepressed and packaged into phage-like transducing particles by helper phages like 80α or φnm1. phages 80α and φnm1 encode structurally distinct dutpases, dut80α (type 1) and dutnm1 (type 2). both dutpases can interact with the sapibov1 stl master repressor, leading to derepression and mobilization. that two stru ... | 2017 | 28400210 |
| east and west african milk products are reservoirs for human and livestock-associated staphylococcus aureus. | staphylococcus aureus frequently isolated from milk products in sub-saharan africa (ssa) is a major pathogen responsible for food intoxication, human and animal diseases. ssa hospital-derived strains are well studied but data on the population structure of foodborne s. aureus required to identify possible staphylococcal food poisoning sources is lacking. therefore, the aim was to assess the population genetic structure, virulence and antibiotic resistance genes associated with milk-derived s. au ... | 2017 | 28400021 |
| effect of sub-inhibitory concentrations of biocides on the architecture and viability of mrsa biofilms. | the effect of sub-minimum inhibitory concentrations (sub-mics) of three biocides (benzalkonium chloride [bzk], trisodium phosphate [tsp] and sodium hypochlorite [shy]) upon the architecture and viability of the biofilms formed by a methicillin-resistant staphylococcus aureus strain of food origin (mrsa 48a) was investigated. images were examined through confocal laser scanning microscopy (clsm) after staining with syto9 and propidium iodide. sub-mics of bzk or tsp reduced the ability of mrsa to ... | 2017 | 28400016 |
| effect of food-related stress conditions and loss of agr and sigb on seb promoter activity in s. aureus. | staphylococcal enterotoxin b (seb) causes staphylococcal food poisoning and is produced in up to ten times higher quantities than other major enterotoxins. while staphylococcus aureus growth is often repressed by competing flora, the organism exhibits a decisive growth advantage under some stress conditions. so far, data on the influence of food-related stressors and regulatory mutations on seb expression is limited and largely based on laboratory strains, which were later reported to harbor mut ... | 2017 | 28400004 |
| prevalence and molecular characterization of staphylococcus aureus in commercially available meat over a one-year period in iowa, usa. | methicillin-resistant staphylococcus aureus (mrsa) is a leading cause of infectious disease morbidity and mortality. previous studies have confirmed the presence of s. aureus, including mrsa, on raw meat products. we investigated the prevalence and molecular epidemiology of s. aureus and mrsa in commercially-distributed antibiotic-free and conventional raw meat products (n = 3290) purchased in 8 iowa retail stores weekly for a period of one year. isolates were characterized using spa typing, and ... | 2017 | 28399994 |
| factors associated with staphylococcus aureus nasal carriage and molecular characteristics among the general population at a medical college campus in guangzhou, south china. | the nasal cavity is the main colonization site of staphylococcus aureus (s. aureus) in human body. nasal carriage may be a strong risk factor for some serious infection. there was still limited information about the nasal carriage for s. aureus in south china. | 2017 | 28399856 |
| frequent isolation of methicillin resistant staphylococcus aureus (mrsa) st398 among healthy pigs in portugal. | although livestock-associated st398 methicillin-resistant staphylococcus aureus (mrsa) has been widely reported in different geographic regions, mrsa carriage studies among healthy pigs in portugal are very limited. | 2017 | 28399155 |
| the recent emergence in hospitals of multidrug-resistant community-associated sequence type 1 and spa type t127 methicillin-resistant staphylococcus aureus investigated by whole-genome sequencing: implications for screening. | community-associated spa type t127/t922 methicillin-resistant staphylococcus aureus (mrsa) prevalence increased from 1%-7% in ireland between 2010-2015. this study tracked the spread of 89 such isolates from june 2013-june 2016. these included 78 healthcare-associated and 11 community associated-mrsa isolates from a prolonged hospital outbreak (h1) (n = 46), 16 other hospitals (n = 28), four other healthcare facilities (n = 4) and community-associated sources (n = 11). isolates underwent antimic ... | 2017 | 28399151 |
| staphylococcus aureus central nervous system infections in children. | central nervous system (cns) infections due to staphylococcus aureus are uncommon in pediatric patients. we review the epidemiology, clinical features, and treatment in 68 patients with a s. aureus cns infection evaluated at texas children's hospital (tch). | 2017 | 28399057 |
| potential involvement of the epidermal growth factor receptor ligand epiregulin and matrix metalloproteinase-1 in pathogenesis of chronic rhinosinusitis. | chronic rhinosinusitis (crs) is a heterogeneous chronic inflammatory disease of the nose and paranasal sinuses that presents without (crssnp) or with nasal polyps (crswnp). features of crswnp are the frequent presence of type 2 allergic inflammation and high prevalence of staphylococcus aureus (sa) colonization. as inflammation persists, sinus tissue undergoes epithelial damage and repair along with polyp growth. since one feature of damaged tissue is enhancement of growth factor signaling, we e ... | 2017 | 28398769 |
| prognosis associated with redo cardiac resynchronization therapy following complete device and lead extraction due to device-related infection. | an increase in the number of cardiac resynchronization therapy (crt) device implantations worldwide has led to a consequent increase in the number of infections associated with the device, making extraction of the crt device inevitable. redo crt implantation after treatment and recovery following device extraction is challenging. this study aimed to evaluate the success rate, complications, and long-term prognosis of redo crt implantation, including the rates of subclavian, cava, and coronary si ... | 2017 | 28398556 |
| antibiotic-loaded mos<sub>2</sub> nanosheets to combat bacterial resistance via biofilms inhibition. | the emergence of antibiotic resistance has resulted in an increasing difficulty treating clinical infections associated with biofilms formation, one of the key processes contributed to enhance antibiotic resistance in return. with the rapid development of nanotechnology, a new way to overcome antibiotic resistance was opened up. based on multiple properties especially antibacterial potential of mos<sub>2</sub> nanosheets that have aroused wide attention, herein, a novel antimicrobial agent to co ... | 2017 | 28398220 |
| ph-dependent antimicrobial properties of copper oxide nanoparticles in staphylococcus aureus. | the antimicrobial properties of cuo nanoparticles have been investigated, but the underlying mechanisms of toxicity remain the subject of debate. here, we show that cuo nanoparticles exhibit significant toxicity at ph 5 against four different staphylococcus aureus (s. aureus) strains, including newman, sa113, usa300, and atcc6538. at this ph, but not at ph 6 and 7, 5 mm cuo nanoparticles effectively caused reduction of sa113 and newman cells and caused at least 2 log reduction, whereas 20 mm kil ... | 2017 | 28397766 |
| the incidence of mrsa infections in the united states: is a more comprehensive tracking system needed? | a review of epidemiological studies on the incidence of mrsa infections overtime was performed along with an analysis of data available for download from hospital compare (https://data.medicare.gov/data/hospital-compare). we found the estimations of the incidence of mrsa infections varied widely depending upon the type of population studied, the types of infections captured and in the definitions and terminology used to describe the results. we could not find definitive evidence that the inciden ... | 2017 | 28396730 |
| methicillin-resistant staphylococcus aureus and antibiotic use in septorhinoplasty: case report and review of literature. | septorhinoplasty is a commonly performed procedure for facial aesthetics and obstructed nasal breathing. there have been only 4 reported cases of methicillin-resistant staphylococcus aureus (mrsa)-associated postoperative complications following septorhinoplasty reported in the literature across all specialties. in this article, we report a case of mrsa-associated infection after an uncomplicated septorhinoplasty. risk stratification and outcome of treatment are described, followed by a review o ... | 2017 | 28396072 |
| vancomycin-intermediate staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors. | vancomycin-intermediate staphylococcus aureus (visa) is associated with genetic changes that may also impact upon pathogenicity. in the current study, we compared the virulence of clinical visa strains with their isogenic vancomycin-susceptible progenitors (vssa). | 2017 | 28396035 |
| [efficacy and safety of linezolid among patients with methicillin-resistant staphylococcus aureus bacteremia]. | objective: to study the efficacy and safety of linezolid for the treatment of patients with bacteremia caused by methicillin-resistant staphylococcus aureus (mrsa). methods: totally 52 cases of mrsa bacteremia patients, from january 2010 to april 2014 in the first affiliated hospital, school of medicine, zhejiang university, were retrospectively analyzed. they were classified into two groups based on linezolid therapeutic regimen: primary treatment with linezolid (19 cases) and alternated to lin ... | 2017 | 28395434 |
| how are the ancient cystic fibrosis patients? cystic fibrosis diagnosed over 60 years-old. | to specify the prevalence of patients diagnosed with cf at age of ≥60 year-old and to analyze their characteristics. | 2017 | 28393935 |
| anti-inflammatory activity of crateva adansonii dc on keratinocytes infected by staphylococcus aureus: from traditional practice to scientific approach using hptlc-densitometry. | leaves of crateva adansonii dc (capparidaceae), a small bush found in togo, are widely used in traditional medicine to cure infectious abscesses. traditional healers of lomé harvest only budding leaves early in the morning, in specific area in order to prepare their drugs. | 2017 | 28392456 |
| ester- and amide-containing multiqacs: exploring multicationic soft antimicrobial agents. | quaternary ammonium compounds (qacs) are ubiquitous antiseptics whose chemical stability is both an aid to prolonged antibacterial activity and a liability to the environment. soft antimicrobials, such as qacs designed to decompose in relatively short times, show the promise to kill bacteria effectively but not leave a lasting footprint. we have designed and prepared 40 soft qac compounds based on both ester and amide linkages, in a systematic study of mono-, bis-, and tris-cationic qac species. ... | 2017 | 28392192 |
| design and development of some thiazole-based flavanoids as novel antibacterial against pathogens causing surgical site infection for possible benefit in bone trauma via inhibition of dna gyrase. | in this study, a novel class of hybrid thiazole-based flavanoid derivatives were synthesized and characterized by ft-ir, (1) h-nmr, (13) c-nmr, mass and elemental analysis. these derivatives were evaluated for antibacterial activity for possible benefit in bone trauma via inhibition of dna gyrase enzyme. results suggested that compounds 9n, 9o, and 9p showed considerable inhibition of dna gyrase with considerable activity against tested forty strains of staphylococcus aureus clinical isolates. m ... | 2017 | 28388011 |
| biological characteristics of staphylococcal enterotoxin q and its potential risk for food poisoning. | to elucidate the biological characteristics and stability of a newly identified staphylococcal enterotoxin q (seq) against heating and digestive enzymes and to evaluate the risk of seq-harbouring staphylococcus aureus in food poisoning. | 2017 | 28375567 |
| ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction in a 13-year-old male. | we present the case of an adolescent male developing an ankylosis of the knee after septic arthritis following anterior cruciate ligament reconstruction (aclr). the patient was shifted to our institution with postoperative septic arthritis associated with a systemic septic condition. before, repeated arthroscopic surgery had been conducted without any improvement. mri showed a concomitant osteomyelitis. the infection (gächter iv, staphylococcus aureus) was controlled by an open surgical approach ... | 2017 | 28342819 |
| international experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines. | the management of infective endocarditis (ie) may differ from international guidelines, even in reference centres. this is probably because most recommendations are not based on hard evidence, so the consensus obtained for the guidelines does not represent actual practices. for this reason, we aimed to evaluate this question in the particular field of antibiotic therapy. | 2017 | 28323194 |
| the effect of negative pressure wound therapy with antiseptic instillation on biofilm formation in a porcine model of infected spinal instrumentation. | this study evaluates the effect of negative pressure wound therapy with antiseptic instillation (npwti) in the clearance of infection and biofilm formation in an in vivo model of infected spinal implants compared to traditional treatment modalities. | 2017 | 28267679 |
| comparing the cost-effectiveness of linezolid to trimethoprim/sulfamethoxazole plus rifampicin for the treatment of methicillin-resistant staphylococcus aureus infection: a healthcare system perspective. | few industry-independent studies have been conducted to compare the relative costs and benefits of drugs to treat methicillin-resistant staphylococcus aureus (mrsa) infection. we performed a stochastic cost-effectiveness analysis comparing two treatment strategies-linezolid versus trimethoprim-sulfamethoxazole plus rifampicin-for the treatment of mrsa infection. | 2017 | 28232163 |
| prevention of staphylococcus aureus ventilator-associated pneumonia: conventional antibiotics won't cut it. | | 2017 | 28158521 |
| staphylococcus aureus in the intensive care unit: are these golden grapes ripe for a new approach? | staphylococcus aureus is the leading cause of infection in the setting of critical illness and injury. this pathogen causes life-threatening infection in otherwise healthy individuals and also complicates the clinical course of patients requiring intensive care as a result of their primary medical or surgical disease processes. s. aureus infection in the intensive care unit (icu) most commonly manifests as sepsis, ventilator-associated pneumonia, and infection of surgical sites and indwelling me ... | 2017 | 28003353 |
| antimicrobial properties of diamond-like carbon/silver nanocomposite thin films deposited on textiles: towards smart bandages. | in the current work, a new antibacterial bandage was proposed where diamond-like carbon with silver nanoparticle (dlc:ag)-coated synthetic silk tissue was used as a building block. the dlc:ag structure, the dimensions of nanoparticles, the silver concentration and the silver ion release were studied systematically employing scanning electron microscopy, energy dispersive x-ray spectroscopy and atomic absorption spectroscopy, respectively. antimicrobial properties were investigated using microbio ... | 2016 | 28773494 |
| deposition of antimicrobial copper-rich coatings on polymers by atmospheric pressure jet plasmas. | inanimate surfaces serve as a permanent reservoir for infectious microorganisms, which is a growing problem in areas in everyday life. coating of surfaces with inorganic antimicrobials, such as copper, can contribute to reduce the adherence and growth of microorganisms. the use of a dc operated air plasma jet for the deposition of copper thin films on acrylonitrile butadiene styrene (abs) substrates is reported. abs is a widespread material used in consumer applications, including hospitals. the ... | 2016 | 28773396 |
| prevalence of vancomycin resistant staphylococcus aureus (vrsa) in methicillin resistant s. aureus (mrsa) strains isolated from burn wound infections. | the increase in resistance of methicillin resistant staphylococcus aureus (mrsa) strains to vancomycin has been perceived as a formidable threat in the therapeutic fields. the present study investigated the vancomycin resistance traits of mrsa isolates [vancomycin resistant s. aureus (vrsa)] collected from burn patients. | 2017 | 28757721 |
| corrigendum to "cloning and characterization of l-lactate dehydrogenase gene of staphylococcus aureus" [anaerobe 24 (2013) 43-48]. | | 2016 | 28754300 |
| extraction of a cardiofix neurostimulator with concomitant laser-assisted lead and intracardiac cardiac defibrillator extraction due to staphylococcus aureus pocket infection. | | 2016 | 28491671 |
| inhibited bacterial adhesion and biofilm formation on quaternized chitosan-loaded titania nanotubes with various diameters. | titania nanotube-based local drug delivery is an attractive strategy for combating implant-associated infection. in our previous study, we demonstrated that the gentamicin-loaded nanotubes could dramatically inhibit bacterial adhesion and biofilm formation on implant surfaces. considering the overuse of antibiotics may lead to the evolution of antibiotic-resistant bacteria, we synthesized a new quaternized chitosan derivative (hydroxypropyltrimethyl ammonium chloride chitosan, hacc) with a 27% d ... | 2016 | 28773281 |
| clonal diversity of methicillin-sensitive staphylococcus aureus from south australian wallabies. | seven methicillin-sensitive staphylococcus aureus nasal isolates from apparently healthy captive and wild wallabies were characterised by dna microarray and antibiotic susceptibility assays. isolates were found to belong to uncommon clonal complexes including those previously associated with birds, pigs and humans. | 2016 | 28616475 |
| synthesis, characterization, antimicrobial studies and corrosion inhibition potential of 1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane: experimental and quantum chemical studies. | the macrocylic ligand, 1,8-dimethyl-1,3,6,8,10,13-hexaazacyclotetradecane (mhacd) was synthesized by the demetallation of its freshly synthesized ni(ii) complex (nimhacd). successful synthesis of nimhacd and the free ligand (mhacd) was confirmed by various characterization techniques, including fourier transform infra-red (ft-ir), proton nuclear magnetic resonance (¹h-nmr), carbon-13 nuclear magnetic resonance ((13)c-nmr), ultraviolet-visible (uv-vis), and energy dispersive x-ray (edx) spectrosc ... | 2016 | 28787909 |
| the effect of mupirocin- and fusidic acid-nasal packings, placed after septoplasty, on the nasal bacterial profile. | to examine the effects, after septoplasty, of local antibiotic pomades as an alternative to prophylactic antibiotic use, which is a controversial matter among the otolaryngologists, on nasal flora and bacterial growth. | 2016 | 28683247 |
| [outpatient management of community acquired meticillin resistant staphylococcus aureus (mrsa) in belgium]. | meticillin resistance is observed among s.aureus strains since 1961 and is due to the synthesis by s.aureus of a modified penicillin binding proteins named pbp2a with decreased affinity to meticillin. meticillin-resistant s.aureus (mrsa) strains are resistant to all betalactam antibiotics except ceftaroline. three epidemiological type of mrsa are now described globally in europe and certainly in belgium. these different types of mrsa differ by their genetic composition, the presence of virulence ... | 2016 | 28525232 |
| methicillin-resistant staphylococcus aureus from infections in horses in germany are frequent colonizers of veterinarians but rare among mrsa from infections in humans. | a total of 272 methicillin-resistant staphylococcus aureus (mrsa) from equine infections originating from 17 equine hospitals and 39 veterinary practices in germany as well as 67 isolates from personnel working at equine clinics were subjected to molecular typing. the majority of isolates from horses was attributed to clonal complex (cc) 398 (82.7%). within cc398, 66% of isolates belonged to a subpopulation (clade) of cc398, which is associated with equine clinics. mrsa attributed to cc8 (st254, ... | 2016 | 28616471 |
| nothing inside the heart - combining epicardial pacing with the s-icd. | | 2015 | 28491598 |
| antibacterial modification of kirschner wires with polyluteolin toward methicillin-resistant staphylococcus aureus (mrsa). | in this study we report antibacterial modification of kirschner wires (k-wires) with polyluteolin (pl) toward methicillin-resistant staphylococcus aureus (mrsa). k-wires were modified by immersing them in the luteolin-containing aqueous solution for 24 h. characterizations using scanning electron microscopy and electrochemical methods confirmed the presence of the pl coatings on the k-wires. the pl-coated k-wires were further found to show antibacterial activity toward mrsa and remained unimpair ... | 2015 | 28793478 |
| staphylococcus aureus infections following knee and hip prosthesis insertion procedures. | staphylococcus aureus is the most common and most important pathogen following knee and hip arthroplasty procedures. understanding the epidemiology of invasive s. aureus infections is important to quantify this serious complication. | 2015 | 28428876 |
| nanostructured titanium-10 wt% 45s5 bioglass-ag composite foams for medical applications. | the article presents an investigation on the effectiveness of nanostructured titanium-10 wt% 45s5 bioglass-1 wt% ag composite foams as a novel class of antibacterial materials for medical applications. the ti-based composite foams were prepared by the combination of mechanical alloying and a "space-holder" sintering process. in the first step, the ti-10 wt% 45s5 bioglass-1 wt% ag powder synthesized by mechanical alloying and annealing mixed with 1.0 mm diameter of saccharose crystals was finally ... | 2015 | 28788008 |
| clinical and bacteriological efficacy of twice daily topical retapamulin ointment 1% in the management of impetigo and other uncomplicated superficial skin infections. | cutaneous bacterial infections are common in children and adults and frequently are caused by staphylococcus aureus (s. aureus). treatment failures with topical agents are not uncommon and have been shown to be secondary to bacterial resistance. | 2015 | 28491950 |
| evaluation of antimicrobial activity of curcuma longa rhizome extract against staphylococcus aureus. | the in vitro antimicrobial activity of different fractions obtained from rhizome of curcuma longa was investigated against standard strain and clinical isolates of staphylococcus aureus. the clinical isolates were found more sensitive for different fractions, than the standard strain of s. aureus. scanning electron microscopic observations revealed that test pathogen treated with c. longa extract showed morphological deformity, with partial lack of the cytoplasmic membrane, which leads to cell d ... | 2015 | 28626697 |
| is methicillin-resistant staphylococcus aureus colonization associated with worse outcomes in copd hospitalizations? | although methicillin-resistant staphylococcus aureus (mrsa) colonization is common in chronic obstructive pulmonary disease (copd) patients, its effect on the course of copd hospitalization remains unknown. | 2015 | 28626792 |
| an organometallic structure-activity relationship study reveals the essential role of a re(co)3 moiety in the activity against gram-positive pathogens including mrsa. | the worrying appearance of microbial resistance to antibiotics is a worldwide problem which needs to be tackled urgently. microbial resistance to the common classes of antibiotics involving purely organic compounds unfortunately develops very rapidly and in most cases, resistance was detected soon after or even before release of the antibiotic to the market. therefore, novel concepts for antibiotics must be investigated, and metal-containing compounds hold particular promise in that area. taking ... | 2015 | 28553471 |
| septic shock due to implantable cardiac defibrillator related infection. | infection is an important complication of cardiac device implantation. we report the case of a 61 year old patient presenting with septic shock caused by cardiac device infection (cdi) three-weeks after device implantation. at initial presentation, there was an absence of both localising signs and echocardiographic evidence of cdi. later, staphylococcus aureus was cultured from blood and the pre-pectoral pocket. 48 hours after admission the device and leads were explanted in theatre by simple tr ... | 2017 | 28496687 |
| lack of horizontal gene transfer of methicillin-resistance genetic determinants from pbp2a-positive, coagulase-negative staphylococci to methicillin-sensitive staphylococcus aureus using transcutaneous electrical nerve stimulation (tens). | previous research shows that approximately half of the coagulase-negative staphylococci (cns) isolated from patients in the intensive care unit (icu) at belfast city hospital were resistant to methicillin. the presence of this relatively high proportion of methicillin-resistance genetic material gives rise to speculation that these organisms may act as potential reservoirs of methicillin-resistance genetic material to methicillin-sensitive staphylococcus aureus (mssa). mechanisms of horizontal g ... | 2007 | 28700890 |
| differential growth of epidemic methicillin-resistant staphylococcus aureus in vancomycin. | this study examines the ability of isolates representing the 17 epidemic methicillin-resistant strains of staphylococcus aureus to grow in increasing levels of vancomycin. only emrsas 1, 2, 8, 11, 12 and 15 showed any growth and were designated emrsas 1a, 2a, 8a, 11a, 12a and 15a. on population analysis, these strains all produced clones that grew on 32 µg/ml vancomycin, while emrsa 12a and 15a grew at 128 µg/ml. this was associated with increased resistance to lysostaphin and teicoplanin, a los ... | 2005 | 28700863 |
| screening for methicillin resistance in staphylococcus aureus and coagulase-negative staphylococci: an evaluation of three selective media and mastalex-mrsa latex agglutination. | laboratory confirmation of mrsa is important for the implementation of infection control; conventional screening culture methods take up to five days for confirmation. the purpose of this study is to ascertain the efficiency of three selective media for growth of methicillin-resistant staphylococcus aureus (mrsa) before and after enrichment in salt broth, and to evaluate the mastalex-mrsa latex agglutination kit for detection of methicillin resistance. screening swabs were collected from 63 pati ... | 2003 | 28700886 |
| bacteriophage pattern and methicillin resistance of staphylococcus aureus isolated from hospitalised patients. | ninety two strains of staphylococcus aureus isolated from hospitalized patients were phage grouped and phage typed and their resistance pattern to methicillin were studied. forty five (48.9%) strains were nontypable, followed by mixed group in 23 (25%). the phage groups i, ii, iii, v and miscellaneous groups were 3.3 per cent, 7.6 per cent, 8.7 per cent, 1 per cent and 3.3 per cent respectively. majority of the strains were methicillin resistant. out of 45 nontypable strains 33 (73.3%) were meth ... | 1997 | 28769482 |
| use of amoxicillin and clavulanic acid (augmentin) in the treatment of skin and soft tissue infections in children. | the efficacy and safety of amoxicillin plus clavulanic acid, a combination of antibiotics potentially effective against beta-lactamase producing bacteria, was compared with that of amoxicillin, erythromycin and co-trimoxazole in an open label, randomized trial in 200 children with mild to severe skin and soft tissue infections. the majority (47%) had impetigo. fifty (25%) children had mild pyodermas, 56 (28%) had moderate and 94 (47%) children had severe pyodermas. a pure growth of staphylococcu ... | 1997 | 28769450 |
| efficacy of a fatty acid-lactic acid postmilking teat germicide in reducing incidence of bovine mastitis. | the efficacy of a postmilking teat germicide containing lauricidin(®), and caprylic, capric, and lactic acids was evaluated against new udder infections caused by staphylococcus aureus and streptococcus agalactiae . the germicide was evaluated in two controlled infection trials using two dilutions of a concentrate. active ingredients of the concentrate were 1% lauricidin(®), 5% caprylic/capric acids, and 6% lactic acid. the first dilution contained one part germicide to seven parts distilled wat ... | 1988 | 28398858 |