| species-specific tissue antigens. iii. immunological relationships of enzymic antigens in various species. | immunological relationships have been investigated with acid and alkaline phosphatases, cystine aminopeptidase, beta-acetylglucosaminidase, beta-glucuronidase, catalase and l-glutamate dehydrogenase of human, monkey, mouse, rat, rabbit, dog, cattle, sheep, cat, pig, guinea-pig and chicken organ extracts by means of immunodiffusion and immunoelectrophoresis. extensive cross-reactions among the antigens of most of the enzymes were observed. however, enzymic proteins of acid and alkaline phosphatas ... | 1975 | 55325 |
| studies with the macrophage migration inhibition (mmi) test in patients with malignant disease. | macrophage migration inhibition (mmi) tests have been carried out using lymphocytes from twenty-six patients with malignant disease and from twenty-two other subjects. the antigens used were the same as those employed in the macrophage electrophoretic mobility (mem) test. the results indicate that the inforation obtained using the mmi test is similar to that found with the mem test. | 1975 | 55328 |
| inhibition of anaphylactic histamine release by forssman antiserum. i. characteristics of the reaction and inhibitor. | forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an igg antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. this forssman antibody did not itself cause histamine release or depletion of lung histamine stores. the igm haemolysin component of the forssman antiserum was not associated with inhibitory activity. the inhibition by the igg forssman ant ... | 1976 | 55380 |
| aglycosylantibody. effects of exoglycosidase treatments on autochthonous antibody survival time in the circulation. | rabbit anti-hapten antibodies were purified by affinity chromatography and characterized immunochemical for in vivo studies of their blood clearance rate and organ distribution after treatment with various glycosidases. following sequential removal of sialic acid, galactose, and n-acetylglucosamine with the appropriate cellulose-immobilized exoglycosidases, the antibody populations were recharacterized, radiolabeled, and introduced intravenously into the original animals. using double radioiodin ... | 1976 | 55413 |
| identification of a macrophage-specific cell surface antigen. | a mouse-specific macrophage antigen (msma) was identified in np-40 extracts of 125i-radiolabeled mouse preitoneal macrophages by using a rabbit anti-mouse macrophage serum (ams) and sds-polyacrylamide gel electrophoresis. the antigen was shown to have a m.w. of 83,000 daltons and was present on both normal and "activated" peritoneal macrophages. msma was also present on syngeneic adherent spleen cells, allogeneic peritoneal macrophages, a mouse macrophage cell line (p388d1), and exhibited some c ... | 1976 | 55433 |
| immunochemical studies on blood groups lxii. fractionation of hog and human a, h, and ah blood group active substance on insoluble immunoadsorbents of dolichos and lotus lectins. | the purified lectins from lotus tetragonolobus and dolichos biflorus were coupled to sepharose 2b to make insoluble adsorbents for purification and fractionation of blood group a and h active glycoproteins. with both adsorbents, hog gastric mucin a + h blood substance (hgm), purified by phenol-ethanol precipitation, yielded fractions showing only a, only h, or ah activities. the ah fraction was obtained when the adsorbent column was overloaded with hgm and its a and h specificities seem to be ca ... | 1976 | 55452 |
| proceedings: histamine-releasing activity of soft hemp and flax dusts. | | 1975 | 55479 |
| [biogenic amines in endocrine cells producing polypeptide hormones. the apud-cells (pearse) (author's transl)]. | apud-cells (a = amine, p = pprecursor, u = uptake, d = decarboxylation) are endocrine cells with numerous common characteristics: 1. they produce polypeptide hormones of low molecular weight. 2. they possess specific 1-amino acid decarboxylases to synthesize catecholamines and/or 5-hydroxytryptamine from precursors. 3. a part of the apud-cell family primarily accumulates biogenic amines within their cytoplasm. 4. all apud-cells are rich in specific secretory granules that are the morphological s ... | 1976 | 55515 |
| letter: potentiation of bronchodilators by glucocorticoids. | | 1976 | 55619 |
| essential fatty acids and fetal brain growth. | the fetal brain accumulates long-chain (c20 and 22) polyunsaturated fatty acids--arachidonic and docosahexaenoic--during cell division. de-novo synthesis of these acids does not occur and they are thought to be either directly derived from food or by metabolism from linoleic and linolenic acids, respectively. administration of isotopically labelled linoleic and linolenic acids to pregnant guineapigs showed that only a small proportion of the label was converted to their respective long-chain pol ... | 1976 | 55720 |
| serum-high-density-lipoprotein and atherosclerotic heart-disease. | serum-high-density-lipoprotein (h.d.l.) concentrations were determined in 49 men who had had a myocardial infarction and in 102 healthy, middle-aged men, all from northern sweden. a quantitative immunological assay based on a monospecific antiserum to the main polypeptide (apoprotein a-i) of h.d.l. was used. the mean h.d.l. concentration was significantly lower in the men with coronary heart-disease than in the controls. the results accord with the hypothesis that high levels of h.d.l. to some e ... | 1976 | 55778 |
| letter: a,y, and d determinants in liver cells of hbsag carriers. | | 1976 | 55878 |
| editorial: which prosthetic valve? | | 1976 | 55897 |
| letter: rifampicin: for tuberculosis only? | | 1976 | 55919 |
| [pathogenesis of larval ascariasis]. | | 1975 | 55954 |
| humoral and cellular immune response to uveal and joint tissue antigens. | the antigens of uveal and joint tissues were investigated in view of the close association between anterior non-granulomatous uveitis and ankylosing spondylitis. numerous antigenic determinants common to the uvea, the synovail membrane and articular cartilage were demonstrated using soluble and semi-particulate tissue extracts. no circulating auto-anti-uveal or joint tissue antigens could be detected in the sera of patients with anterior non-granulomatous uveitis or ankylosing spondylitis. cellu ... | 1976 | 55957 |
| regulation of reaginic antibody formation in animals. | | 1975 | 56008 |
| biology of immunoglobulin e. molecular basis of reaginic hypersensitivity. | | 1975 | 56010 |
| [preparation of porcine iga and its detection using the fluorescent antibody technic]. | the preparation of immunoglobulin a (iga) from porcine colostrum, intestinal content and serum is described. the best results were achieved with colostrum, from which an antigen of satisfactory purity was prepared by purification on sephadex g-200, on deae cellulose and subsequent filtration on sephadex g-200. the serum to this antigen raised in rabbits was adsorbed to an immunoadsorbent from porcine serum (ps) or porcine igg. the adsorbtion of the serum against secretory iga (siga) to ps remove ... | 1975 | 56076 |
| [chemically-induced dermatoses, their modeling and selective and nonspecific suppression]. | | 1975 | 56103 |
| [hemagglutinin specificity of cl. botulinum types a, b, and f in reaction with erythrocytes of various animals]. | the following differences were revealed in the haemagglutination reaction with the erythrocytes of man, sheep, rabbit, chicks and mice between the haemagglutinins of cl. botulinum, types a, b and f, having a close affinity with one another: haemagglutinin of type a actively reacted with the erythrocytes of man, sheep, rabbit, rats and chicks; haemagglutinin of type b reacted only with the erythrocytes of man and rabbits; haemagglutinin of type f failed to react with any of the types of the eryth ... | 1975 | 56111 |
| the influence of gramicidin a and valinomycin of the permeability of mammalian erythrocytes. | 1. the k+ transport in erythrocytes induced by gramicidin a or valinomycin is a first-order reaction. the activation energy of the induced transport is low and amounts to 6 and 10 kcal/mole, respectively. the indirect method for calculation of the driving force of diffusion, c, is given; in pig erythrocytes the c value for gramicidin a is 21.7, and for valinomycin 35.4 mm-kcl. 2. the valinomycin-induced transport was found to be the same in erythrocytes and biomolecular lipid membranes. the gram ... | 1975 | 56113 |
| neurogenic mechanisms in the cerebrovascular bed. autonomic nerves, amine receptors and their effects on cerebral blood flow. | | 1975 | 56123 |
| interrelationships among rna tumor viruses and host cells. | | 1975 | 56125 |
| a comparative study of beta-crystallin from six mammals. | | 1976 | 56252 |
| fractionation of immunocompetent cells by free-flow cell electrophoresis. | | 1975 | 56322 |
| g-band patterns of swine chromosomes. | a simple inexpensive and reproducible g-banding technique for swine chromosomes is described that permits precise identification of individual chromosome pairs. the g-bands were obtained by either ssc (saline-citrate-solution), or trypsin pretreatment methods. | 1975 | 56349 |
| antibodies specific to isoniazid and isonicotinic acid. | rabbit antisera to isoniazid (inh) and its major metabolite, isonicotinic acid (ina), were prepared by immunization with conjugates of these compounds with human serum albumin. the antisera were rendered hapten-specific by exhaustive absorption with the immunizing carrier. purified anti-hapten antibodies were also isolated with appropriate immunosorbents. as demonstrated by inhibition of the quantitative precipitin curves and of precipitating immune complexes in immunodiffusion tests, the antibo ... | 1976 | 56409 |
| effects of (na+ + k+)-atpase-specific antibodies of enzymatic activity and monovalent cation transport. | antibodies have been obtained that specifically interact with the transport enzyme (na+ + k+)-activated atpase. the antigen used was purified (na+ + ka+)-atpase from canine renal medulla. purified gamma globulin from immunized animals, but not from control animals or preimmune serum, inhibited (na+ + ka+)-atpase from canine renal medullar with reduction of activity to 33 +/- 4 (sd)% in concentration-dependent manner. maximum inhibition occurred in less than 5 minutes at 37 degrees c. the mg++ -d ... | 1975 | 56442 |
| inhibition of adenosine-3',5'-cyclic monophosphate phosphodiesterase by potential antiallergic compounds. | | 1976 | 56695 |
| immune response of guinea-pigs to chemically abbreviated prepatent metastrongylus apri infection. | the effect of chemical abbreviation of the primary infection dose (pid) of 160 infective larvae of metastrongylus apri on the immune status of the guinea-pig host was studied. the criteria used for assessing the status of immunity consisted of clinical manifestations following administration of a challenge infection dose (cid) of 800 infective larvae of m. apri, the rate of worm recovery 15 days post-cid and the rate of mortality following administration of cid. among the guinea-pigs of the main ... | 1976 | 56737 |
| pharmacologically active substances in venoms of the bald-faced hornet, vespula (dolichovespula) maculata, and the yellow jacket, vespula (vespula) maculifrons. | | 1976 | 56792 |
| rhinitis of pigs: a gross staining method for macroscopic examination of the nasal mucosa. | a phloxine-alcian blue (phab) method has been used to stain the porcine nasal mucosa for macroscopic examination. applied to either fresh or fixed specimens it stains respiratory epithelium dark blue and non-cilated epithelium, including the metaplastic epithelia of rhinitis, bright pink. the phab technique is simple, inexpensive and dependable, and is suitable for routine application in the post mortem room. stained and fixed specimens may be preserved virtually indefinitely. | 1976 | 56799 |
| the activation of antigens of the basement membrane zone by proteolytic enzymes in vitro. | following brief exposure of cryostat sections of human skin to the action of proteolytic enzymes (papain or trypsin), there was a pronounced increase in the antibody binding sites of the basement membrane zone, shown in indirect immunofluorescence by an increased intensity in fluorescence of the basement membrane zone as compared with preparations which had not previously undergone incubation, and by an increase of 5-6 (papain) or 4-5 (trypsin) titre dilution steps. this effect was practically a ... | 1976 | 56855 |
| galactose oxidase as a tool to label a glycoprotein and to study its fixation on isolated guinea-pig ileum receptors. | | 1975 | 56877 |
| proceedings: the immunochemical binding of 14c-histamine. | | 1975 | 56881 |
| a comparison of the fluids from small and large ovarian follicles of the pig. | | 1975 | 56955 |
| incompatibility between c3b and b of guinea-pig and man and its influence on the titration of the alternative pathway factors d and b in these two species. | the incubation of the proteins c3b, b, d and c3 induces enzymatic activation of b and of c3. this system of purified components was applied to the titration of the guinea-pig and human factors d and b in various homologous and heterologous reaction mixtures. on the basis of functional as well as of immunological tests, the d enzymes of both species were found to be related proteins. first, titrations of factor b revealed that both d enzymes activate homologous and heterologous b with comparable ... | 1976 | 57093 |
| late gestation feeding of dichlorvos: a physiological characterization of the neonate and a growth-survival response. | | 1976 | 57112 |
| complement - fixation in the interaction of normal rabbit gamma g' globulin and its fab' fragment. | complement consumption induced by fab' fragments of rabbit igg, irrespectively of their state of aggregation, requires the presence of homologous rabbit igg. up to a certain concentration of fab' fragment, the amount of complement fixed is a linear function of the fab' fragment dose, but further raising of the fab'-fragment concentration does not result in complete complement consumption in the sample. the interaction between fab' fragment and igg is not strictly species specific. | 1976 | 57194 |
| [methods of obtaining standard diagnostic sera to respiratory syncytial virus]. | | 1975 | 57269 |
| [comparative experimental study of the sensitivity of the methods of isolation of tuberculosis antigen with the aid of an antiserum]. | | 1975 | 57318 |
| letter: which prostitute valve? | | 1976 | 57411 |
| possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. | vasoactive intestinal peptide (v.i.p.) has been found in high concentrations both in the gastrointestinal tract and, unexpectedly, in the central nervous system. immunocytochemical studies have demonstrated v.i.p. in nerve-fibers. these findings challenge the concept of v.i.p. as a simple gastrointestinal hormone and suggest a possible neurotransmitter function. | 1976 | 57443 |
| effect of "fractionated" insulins on total plasma insulin binding capacity and insulin requirements in severe diabetes. | serial observations of insulin requirement and total plasma insulin binding capacity have been carried out on six xevere diabetics whose treatment was changed from standard soluble and isophane (nph) insulins to "fractionated" preparations (nordisk insulin ltd). no correlation was found between initial insulin dose and binding capacity, but changes in these two functions during the study period were closely correlated, both for the group as a whole and for individual patients in whom falls in in ... | 1976 | 57444 |
| [the antigenic properties of human prolactin (author's transl)]. | the antigenic properties of human prolactin (hpr) were studied using various methods of radio-immuno assay. the homologous system, the difficulty of which resides in the preparation of the tracer, easily permits measurement of physiological levels. in this systems, blood prolactin in the monkey, has an antigenicity comparable with that of human prolactin, whereas growth hormone and human chorionic somatotropin have feeble or nil antigenic relationship with hpr. human, sheep and pig prolactins ha ... | 1976 | 57589 |
| [development of the ideas of n. n. anichkov at the present stage of our knowledge about atherosclerosis]. | the article discusses the main elements of the infiltrative-combination theory of atherosclerosis, which was formulated and developed by n. n. anichkov. the further development of the main principles of this theory at the current stage of medical science is elucidated. analysis of the mechanisms of penetration of lipids into the vascular wall, the role of metabolism of the main substance and plasmic proteins at the initial stages of atherosclerosis shows that the new data obtained are not at var ... | 1975 | 57767 |
| dna polymerase activity in plasma from leukaemic guinea-pigs. | measurement of dna polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. since the sedimentable dna polymerase is ribonuclease sensitive, uses poly(c).oligo(dg) as template, and bands in a sucrose density gradient at 1-17 g/ml it is thought to be the gplv-associated reverse transcriptase. the soluble dna polymerase is stimulated by ribonuclease and is probably of cellular origin. | 1976 | 57790 |
| on the occurrence of argyrophil cells in salivary glands. | salivary glands (parotid, submandibular and sublingual glands) of nine mammalian species were investigated with respect to presence and localization of argyrophil and argentaffin cells. with the exception of the parotid gland of the rat, no positive staining was observed within the examined glands. in the rat parotid distinctly argyrophil cells could be demonstrated in the intercalated ducts. histochemical studies of the cells, ultrastructural analysis of their cytoplasmic granules as well as th ... | 1976 | 57829 |
| the immunopharmacology of the immediate allergic response in skin. | | 1976 | 57840 |
| rna tumor viruses and human cancer. | | 1976 | 57847 |
| [light- and electron microscopy studies on the nervous network in the gastric mucosa and their relations to the border and mast cells]. | | 1975 | 57851 |
| [pathophysiological significance of endotoxins]. | the biological activities of endotoxin are manifold. besides the drop in platelets and the biphasic change in the number of leukocytes, severe disturbances in the capillary bed are among the first changes observed following the administration of endotoxin. it is well known that endotoxins cause the release of various vasoactive mediators. according to our results endotoxins enhance the activity of histamine and serotonin; these findings may contribute to a better understanding of the action of h ... | 1975 | 57913 |
| blocking the encephalitogenic activity of the c-terminal part of the basic myelin protein in rabbits by treatment with serum. | peptides hnb-92-169 and 116-169, tyr, derivatives of the c-terminal part of bovine myelin basic protein, sensitize rabbits for experimental allergic encephalomyelitis (eae). dissolving these peptides in heat-inactivated normal guinea-pig, human, or monkey serum immediately before emulsification with freund's complete adjuvant (fca) abrogated their disease-inducing activity. dissolving them in homologous or autologous serum only slightly affected the encephalitogenicity. | 1976 | 57920 |
| use of the hemadsorption phenomenon for determining virus and neutralizing antibody titers of rabies. | chicken embryo cells infected with the hep flury strain of rabies virus adapted to tissue culture produced a hemadsorption (had) phenomenon by using goose erthyrocytes. the optimal conditions for had included the incubation of cell cultures at 37c for 3 days after virus inoculation, the use of a 0.4% suspension of goose erythrocytes in phosphate buffer adjusted at ph 6.2, and adsorption of erythrocytes at 4c. this phenomenon was inhibited with anti-rabies serum. virus titer obtained with the had ... | 1976 | 57927 |
| chemical modification of crude timothy grass pollen extract. i. antigenicity and immunogenicity changes following amino group modification. | glutaraldehyde modification was found to reduce the allergenic potency of crude timothy pollen extracts yet even highly substituted materials retained the capability of inducing the formation of allergen-specific antibody in animals. experiments showed that these antibodies were capable of blocking skin test reactions to native timothy allergens in pollen-sensitive human volunteers. the value of glutaraldehyde-modified allergen extracts for use in desensitization vaccine therapy is discussed. | 1976 | 57930 |
| carboxylic ester hydrolases in the thyroid gland of the guinea-pig. a light microscopic study. | the location of cholinesterase and non-specific esterase in the thyroid gland of the guniea-pig was studied with the light microscope. it was found that the idoxyl method for non-specific esterase activity under special conditions is superior to the cholinesterase method in a number of respects for the demonstration of the intra-, inter- and parafollicular cells. when using the indoxyl method the incubation period can be reduced from 2.5-3 hr to 40-50 min. further, the reaction can be followed d ... | 1976 | 57946 |
| a neutral subtilopeptidase inhibitor from porcine serum some evidence for alpha2-macroglobulin. | an inhibitor of neutral subtilopeptidase [ec 3.4.24.4] was purified from porcine serum by salting out with (nh4)2so4, chromatography on anion exchange sephadex, gel filtration with sepharose 6b, and isoelectric focusing. the preparation was homogeneous by electrophoretic and ultracentrifugal criteria, and was shown to be a glycoprotein with a molecular weight of 740,000. it inhibited the caseinolytic activities of thermolysin, subtilisin, trypsin [ec 3.4.21.4], and alpha-chymotrypsin [ec 3.4.21. ... | 1975 | 57960 |
| coated-vesicle shells, particle/chain material, and tubulin in brain synaptosomes. an electron microscope and biochemical study. | coated vesicles (cvs), plain synaptic vesicles (psvs), and nonvesicular flocculent material were isolated from synaptosomes and examined with goniometry and high-resolution electron microscopy after either negative staining or various biochemical procedures. the flocculent material (i.e. the presynaptic matrix material except cv shells) is largely composed of particulate or elongated (chainlike) structures; some of this material (here referred to as particle/chain material) is attached to psvs. ... | 1976 | 57963 |
| letter: cholesterol biosynthesis inhibitor ay9944. | | 1976 | 58136 |
| editorial:m.e.m. and mod-m.e.m. | | 1976 | 58159 |
| letter: insulin resistance during continuous insulin infusion. | | 1976 | 58235 |
| letter: which prosthetic valve? | | 1976 | 58292 |
| a mechanism by which high-density lipoproteins may slow the atherogenic process. | there is a well-documented negative correlation between plasma concentrations of high-density lipoproteins (h.d.l.) and risk of clinically evident atherosclerosis. this may relate to the postulated role of h.d.l. in the transport of cholesterol out of cells. studies of the metabolism of lipoproteins by arterial smooth-muscle cells suggest that a second mechanism also operates, h.d.l. binds to the surface of porcine arterial smooth-muscle cells as effectively as low-density lipoprotein (l.d.l.) b ... | 1976 | 58308 |
| letter: highly purified insulins. | | 1976 | 58350 |
| modulation of the immunologic response of myelin basic protein by extrinsic and intrinsic factors. | | 1976 | 58395 |
| [level of viral antibodies in normal and specific swine and bovine gamma globulin preparations]. | studied were 15 series of normal bovine gamma-globulin, 5 series of normal swine gamma-globulin, 7 series of aujeszky gamma-globulin, 6 series of specific gamma-globulin against edema disease of pigs, 4 series of specific gamma-globulin against paratyphus, 5 series of mixoglobulin-70, and one series of swine poly-globulin. all series of gamma-globulin preparations were studied for the presence of antibodies against mixovirus parainfluenza-3 through the hemagglutinationinhibition reaction, antibo ... | 1975 | 58467 |
| non-specific passive desensitization xx: two important technical details. | for non-specific passive desensitization to be effective two steps are necessary: (1) dialyze concentrated gamma globulin precipitated from plasma or serum by ammonium sulfate and (2) allow time for complete recovery from the initial reaction to antigen aerosols before giving the desensitizing dose of gamma globulin. | 1976 | 58571 |
| induction of tolerance in adult guinea-pigs by two antigen dosage levels and by antigenic competition. | the effect of prior injection of increasing doses of dinitrophenylated bovine serum albumin (dnp-bsa) mixed in freund's complete (fca) or incomplete (ifa) adjuvants on the antibody response to a subsequent challenge with an optimal immunizing dose of dnp-bsa in fca has been examined and compared with the effect of competition with the unrelated antigen bovine gamma-globulin (bgg). an unresponsive state was induced by pretreatments with either a minimal dose of antigen, a large antigen excess or ... | 1975 | 58574 |
| [presence of antigen sv40/t in the nuclear and cytoplasmic fraction of sv40- and para-transformed cells]. | | 1975 | 58585 |
| the importance of calcium for the regulation of cyclic guanosine 3': 5'-monophosphate levels by pancreozymin, carbamoylcholine and ionophore a-23187 in isolated pancreatic acinar cells. | | 1975 | 58614 |
| progressive combined amyloid-elastic stain. | a progressive staining technique is described that will permit demonstration of elastic structures and amyloid deposits in the same section. it is satisfactory for animal as well as human tissues, and for both pericollagen and perirecticulin types of amyloidosis. | 1975 | 58656 |
| release of histamine from lung tissue in vitro by dimethylhydantoin-formaldehyde resin and polyvinylpyrrolidone. | | 1976 | 58664 |
| [immunofluorescent study of antibodies to streptococcus group a polysaccharides in connective tissue sections]. | purified antibodies against a specific determinant of group a streptococcal polysaccharide were obtained. these antibodies were investigated by the immunofluorescent method on tissue sections of the heart and heart valves. no cross-reactions between group a streptococcal polysaccharide and mammalian connective tissue were revealed. | 1976 | 58683 |
| [effects of the electric current on the fundamental processes of stimulation in the heart]. | on the basis of experimental studies on isolated preparations from different regions of the heart and on perfused hearts of animals, it was possible to distinguish at least four basic actions of an electric current: 1. the release of excitations, 2. with continuous current, an electro-tonic influence on the pacemaker activity in the sense of a cathodic advancement, or an anodic inhibition 3. with alternating current, stimulation of the vegetative nerves of the heart, 4. a direct, reversible dama ... | 1975 | 58696 |
| durability of immune protection against experimental autoimmune encephalomyelitis. | | 1976 | 58731 |
| [on the production of anti-human-lymphocyte serum (als) by means of combined local and intravenous immunization in swine]. | lymphocytes of donors' peripheral blood were used for the study of pig antihuman als preparation by means of local and intravenous immunization. the results were compared with those obtained with exclusively local application of the same antigen. antisera were tested from the aspect of activity (lymphoagglutination, lymphocytotoxicity, the rosette inhibition test) and for the presence of unwanted antibodies (haemagglutinins, thromboagglutinins, precipitins to serum proteins). of all alternatives ... | 1976 | 58822 |
| hapten-specific responses to contact sensitizers. use of fluorodinitrobenzene to elicit migration inhibition and macrophage agglutination factors from lymph node cells of contact-sensitive guinea-pigs. | hapten-specific sensitivity of guinea-pigs sensitized to dinitrophenyl (dnp) contactants and to dnp-protein conjugates was investigated by skin test and by antigen-induced elaboration of migration inhibition (mif) and macrophage agglutination factors (maf) from lymph node cells. the delayed contact reaction was highly specific for low doses of contactant and markedly less so for conjugates; lymph node cells elaborted both lymphokines in response to brief exposures to dinitrofluorobenzene (dnfb) ... | 1976 | 58832 |
| the effects of glutaraldehyde treatment and horesradish peroxidase conjugation on the immunoreactivity of bovine myelin encephalitogenic protein. | the effects of the immunoreactivity of bovine myelin encephalitogenic protein (ep) of treatment with glutaraldehyde and conjugation with horeradish peroxidase (hrp) were investigated by complement fixation and immunohistochemistry. both glutaraldehyde treatment and hrp conjugation of ep decreased but did not abolish the reactivity of ep with rabbit anti-ep. conjugation of ep to hrp by the two-step method of avrameas had less detrimental effects on the immunochemical reactivity of ep than did the ... | 1976 | 58926 |
| from the national institute of allergy and infectious diseases of the national institutes of health, the center for disease control, and the bureau of biologics of the food and drug administration: a status report on national immunization against influenza. | | 1976 | 58953 |
| comparison of swine vesicular disease virus and coxsackie b5 virus by serological and rna hybridization methods. | the relatedness of swine vesicular disease virus (svdv) and coxsackie b5 virus has been studied by virus neutralization and immunodiffusion tests and by hybridization of the virus rnas. clearly defined differences between the two viruses were found by the three methods. isolates of svdv from several countries were very closely related but could be differentiated. recent isolates of coxsackie b5 virus also appeared to be similar but clear differences could be detected between these and the protot ... | 1976 | 58963 |
| proceedings: oxidants and human health. | | 1976 | 58982 |
| immunocytochemical localization of mouse alpha 2-macroglobulinlike antigenic determinants on schistosoma mansoni adults. | antiserum prepared in rhesus monkeys against purified mouse alpha 2-macroglobulin (alpha2m) was labeled with peroxidase and incubated with both living and formalin-fixed s. mansoni adults (perfused from mice or rhesus monkeys) in order to test for the presence of mouse alpha2m antigenic determinants on their surfaces. following standard cytochemical processing with the appropriate controls, adult worms of both murine and primate origin were found to have mouse alpha2m-like determinants on their ... | 1976 | 58985 |
| is lactase the receptor and uncoating enzyme for infantile enteritis (rota) viruses? | rotaviruses are now regarded as important causes of diarrhoea in man, cattle, pigs, mice, and possibly other animals. characteristically, disease occurs in newborn and young animals, and infection seems limited to the differentiated gut epithelial cells. the major surface polypeptide of the calf scours rotavirus is glycosylated, and highly purified beta-galactosidase (lactase) interacts with the virus in vitro causing removal of the outer shell of the capsid (uncoating). it is suggested that lac ... | 1976 | 59021 |
| letter: body temperature and malignant hyperthermia. | | 1976 | 59036 |
| swine influenza virus in man. zoonosis or human pandemic? | | 1976 | 59086 |
| virulence for man of a human influenza-a virus antigenically similar to "classical" swine viruses. | the newly isolated human influenza-a strain containing swine antigens isolated in new jersey, u.s.a., was inoculated into six volunteers. clinical reactions were mild although all volunteers were infected. the longest period for which the virus was excreted was 8 days and the shortest 3 days. in its virulence for man the new jersey strain was intermediate between a human and animal virus, and was quite clearly more virulent than known swine viruses. it seems possible that the outbreak in the u.s ... | 1976 | 59094 |
| swine influenza virus and the recycling of influenza-a viruses in man. | sera collected in 1967 and 1972 from people in the 0-100 age-group showed haemagglutination-inhibition (h.i.) antibody to swine virus a/iowa/15/30 (hsw1n1) in greatest number and with highest titre in people born before 1918. a slight decrease was observed from 1967 to 1972 in the number of sera with antibody to swine virus and in the height of the titres. the recently isolated a/new jersey/10/76 (hsw1n1) virus showed a result comparable to that of the swine/1930 virus in sera of 1972. on the an ... | 1976 | 59252 |
| letter: vasoactive intestinal polypeptide. | | 1976 | 59264 |
| prostaglandins and cardiac anaphylaxis. | | 1976 | 59297 |
| hematoxylin substitutes: a survey of mordant dyes tested and consideration of the relation of their structure to performance as nuclear stains. | in the search for hematoxylin substitutes 26 dyes were more or less extensively tested for performance as nuclear stains, usually in combination with aluminum, chronic, ferrous and ferric salts. reports from the literature on hematoxylin substitutes were also considered, and efforts were made to obtain samples of favorably reported dyes and test them. the reports on anthocyanins include isolated reports on several berry juices and a considerable number of studies on sambucus niger and vaccinium ... | 1976 | 59410 |
| a combined silver and acetylcholinesterase method for staining intramuscular innervation. | a combined acetylcholinesterase and silver stain for demonstrating the intramuscular innervation of fresh frozen tissue is described. intramuscular nerves, subterminal axons, and motor end plates are simultaneously stained brown or black with minimal staining of connective tissue and muscle fibers in longitudinal sections 30-100 mu thick. the method has been applied to fetal and adult rat, porcine, and bovine skeletal muscle. antemortem and postmortem tissue samples stained equally well. the met ... | 1976 | 59425 |
| the effect of age and strain on the amount of neurosecretion. | | 1975 | 59484 |
| the cutaneous reactions to kallikrein, prostaglandin and thurfyl nicotinate in chronic urticaria and the effect of polyphloretin phosphate. | the erythema and wealing resulting from the application of thurfyl nicotinate ointment (trafuril) and from the inoculation of kallikrein has been studied in patients with chronic urticaria and normal controls. polyphloretin phosphate (ppp) suppressed the reaction in controls but in patients with urticaria it increased the reactions to trafuril and had little effect on the kallikrein reaction. ppp also suppressed the pge2-induced erythma in normal controls but not in urticaria patients. in a sepa ... | 1976 | 59506 |
| [study of histamine in asthma]. | histamine is generally considered as the principal chemical mediator in experimental allergy of type i and anaphylaxis. however, its part in human bronchial asthma remains discussed, because neither the dosage of histamine in blood, nor the use of antihistaminics have furnished any real evidence. this study is dealing with two elements: the importance of local bronchopulmonary phenomena, and the associated mediators also liberated in asthma, such as srsa. ecfa, kinines, prostaglandins and disord ... | 1976 | 59539 |
| antigenic differences among bovine and porcine factor viii concentrates. | three anti-factor-viii antibodies from hemophiliacs were reacted with samples of batches of maws commerical bovine and porcine factor viii concentrates manufactured over a 12-year period. the apparent antibody concentrations varied widely with the different batches of concentrates. the variations are probably due to intrinsic differences in the antigenic nature of the factor viii in the different preparations. with the older porcine concentrates, the low apparent concentrations may be in part du ... | 1976 | 59540 |
| [study of the complex between porcine plasmin and alpha2-macroglobulin (author's transl)]. | porcine plasmin (ec 3.4.21.7) is obtained from plasminogen activated by human urokinase. this enzyme can bind, in an equimolecular ratio, to an alpha2-macroglobulin isolated from porcine serum. the number of active sites of plasmin has been determined through a burst titration of nitroaniline during the presteady-state hydrolysis of an amide substrate (n-alpha-carbobenzoxy-l-arginine-p-nitroanilide). the kinetic constants relative to a very sensitive ester substrate (n-alpha-carbobenzoxy-l-lysin ... | 1976 | 59608 |
| [autoantibodies to the common antigenic determinant of group a streptococcal polysaccharide and epithelial cells of mammalian thymus and skin]. | a cross-reactive (cr) antigenic determinant in the polysaccharide of group a streptococus and the mammalian thymus and skin was studied. the cr antigen was found in adult humans and human embryos irrespective of the blood group, as well as in the tissues of all the animal species studied, including rabbits immunized with streptococcus and producing antibodies to a polysaccharide. evidence was obtained that the antibodies elaborated to the cr determinant of polysaccharide a and of the tissue epi ... | 1976 | 59613 |
| aspects of the secondary antibody response to ox insulin in the hartley guinea-pig; the use of chemically modified ox insulin to delineate the antigenic determinants of ox insulin. | the use of a quinea-pig model to study the immunogenicity of the insulin molecule is presented. the hartley guinea-pig has been shown consistently to form antibody to ox insulin, when given in a water-in-oil emulsion containing pertussis vaccine as adjuvant. after log transformation of standardized antibody titres to iodo-ox insulin, a valid statistical comparison of the antibody response to different ox insulin preparations could be made. antibody cross-reacting with ox insulin, but not iodo-ox ... | 1976 | 59648 |
| determinant competition during the immune response to n-acyl derivatives of ox insulin in the hartley guinea-pig. | subgroups of female hartley guinea-pigs were immunized with n-carbamylated ox insulin, n-maleylated ox insulin, n-phthaloylated ox insulin, or with the crystalline ox insulin from which the n-acylated insulins had been prepared. the immunogens were administered in water-in-oil emulsions containing pertussis vaccine as adjuvant. sera obtained 20 days after secondary immunization were assayed for their antibody titres to iodo-ox insulin and their insulin-binding capacities. the data were log trans ... | 1976 | 59652 |