| factor viii concentrate from cold sterilized human plasma. | beta-propiolactone (beta-pl) in combination with uv irradiation (uv) is an established method for the sterilization of factor ix concentrate or stabilized human serum. because of the extreme sensitivity of factor viii to beta-pl, the standard beta-pl/uv procedure cannot be used to obtain hepatitis-safe factor viii concentrate. it has been shown in chimpanzees that from a cryoprecipitate containing hepatitis non-a, non-b viruses in addition to hepatitis b viruses a factor viii concentrate (160 u/ ... | 1983 | 6418593 |
| effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in the mammalian penis. | plasma levels of vasoactive intestinal polypeptide (vip) in the corpora cavernosa penis and dorsal penile veins greatly exceeded those measured in the limb or caudal veins during anaesthesia in various mammals (bennett's wallaby, barbary sheep, cheetah, puma, sooty mangabey, pigtail macaque and chimpanzee). tactile stimulation of the penis immediately before or during collection of blood samples resulted in an increase. in the wallaby, vip levels (mean +/- s.e.m.) in blood samples collected from ... | 1984 | 6420493 |
| experimental infection of chimpanzees with the hbsag-associated delta (delta) agent: an ultrastructural study. | characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non-a, non-b hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. the ultrastructural changes were maximal during the intrahepatic production of the delta antigen, but were detected also independently of delta-ag expression. the ultrastructural analogies provide further evidence that delt ... | 1984 | 6420512 |
| a comparative evaluation of the cognitive skills of the chimpanzee and the monkey. | a review of selected aspects of cognitive performance in apes and in monkeys suggests that only rarely can we at this time demonstrate greater cognitive competence in the ape than in the monkey. instead it seems that the ape's cognitive style differs qualitatively from that of the monkey: not in the direction of greater capacity (using this term as a measure of continuously increasing ability), but in the way that the ape applies itself to a novel situation. from this it would follow that the gr ... | 1983 | 6421764 |
| inactivation of hepatitis b and hutchinson strain non-a, non-b hepatitis viruses by exposure to tween 80 and ether. | titrated stocks of hepatitis b virus and hutchinson strain non-a, non-b hepatitis virus were diluted in normal serum to contain, respectively, greater than or equal to 10(6) and greater than or equal to 10(4) chimpanzee infectious doses (cid50) per milliliter and exposed to 1% tween 80 and 20% ether at 4 degrees c for 18 h. after evaporation of the ether, the treated sera were each inoculated into two chimpanzees. the animals remained free of serologic and biochemical evidence of hepatitis durin ... | 1984 | 6422634 |
| beta-propiolactone for the inactivation of non-a/non-b type 1 hepatitis virus capable of inducing cytoplasmic tubular ultrastructures in chimpanzees. | non-a/non-b type 1 hepatitis virus may be recognized because it induces characteristic tubular ultrastructures in the hepatocyte cytoplasm of chimpanzees. 3 chimps received 0.1 ml of a chimp serum containing more than 100 chimp infecting units of non-a/non-b type 1 hepatitis virus after it had been treated with beta-propiolactone with or without combined ultraviolet irradiation. all of the chimps escaped infection throughout the observation period of 23 weeks. the treatment of the serum with bet ... | 1984 | 6422638 |
| [analytical description and comparison of profiles and sections of the skull by polynomial equations. illustration of the procedure]. | skull profiles and related sections may be worked in order to obtain the equation of the curve for best fitting. polynomials of 6-7 nth degree give very high values of coefficient of determination. the technique is fully automatized and requires a tv-camera interfaced with a computer with specific hardware devices and software packages. main routine gives coefficients of the equation, their standard deviation, standard errors, variance and covariance matrix. accessory routines provide standardiz ... | 1984 | 6422961 |
| the evolutionary relationships of man and orang-utans. | man shares uniquely few morphological features with either the chimpanzee or the gorilla, whereas there are many features that suggest affinities between man and the orang-utan, to whom the fossil sivapithecus appears to be closely related. if these are unique features, inclusion of sivapithecus, man and the orang-utan in a single clade, distinct from that containing the african apes, is justified but contrary to current opinion. | 1984 | 6424028 |
| ultrastructural changes in human hepatocytes in acute non-a, non-b hepatitis. | ultrastructural findings in the liver of a 52-year-old man with acute non-a, non-b (nanb) post-transfusion hepatitis are described. apart from non-specific alterations also known to occur in hepatocytes in hepatitis a and b--such as proliferation of membranes of smooth endoplasmic reticulum, formation of membrane-bound cytoplasmic vacuoles containing electron-dense material, and accumulation of distorted peroxisomes--unique cytoplasmic changes were observed that have not previously been describe ... | 1983 | 6424227 |
| x-linked, polymorphic genetic variation of thyroxin-binding globulin (tbg) in baboons and screening of additional primates. | x-linked polymorphic variation of thyroxin-binding globulin (tbg) is observed in several human groups. isoelectric focusing of plasma samples labeled in vitro with [125i]thyroxin, followed by autoradiography, also reveals genetically determined polymorphic electrophoretic variation in baboon tbg. the protein detected by this method in baboon plasma is immunologically similar to human tbg and is distinct from the other thyroxin-binding proteins, albumin and prealbumin. the isoelectric patterns of ... | 1984 | 6424646 |
| non-a, non-b hepatitis-like nuclear particles in nonparenchymal cells of the liver. | nuclear particles, morphologically similar to those seen in hepatocytes during non-a, non-b (nanb) hepatitis, were detected in several types of nonparenchymal cells in 10 human liver-biopsy specimens, including cases of hepatitis a and b and nonviral hepatic disease. they were also found in nonparenchymal cells of the liver in two of four normal chimpanzees and in two of four chimpanzees during experimental nanb viral hepatitis. in nonparenchymal cells the particles formed loose-to-intermediate ... | 1984 | 6425423 |
| nuclear particles of non-a, non-b type in healthy volunteers and patients with hepatitis b. | in an electron microscopic study, nuclear aggregates of virus-like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis b and 17 of 18 patients with hepatitis non-a, non-b. the incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. we conclude that these nuclear particles are not specific ultrastructural markers of hepatitis ... | 1984 | 6427089 |
| face touching in monkeys, apes and man evolutionary origins and cerebral asymmetry. | the evolution of face touching, i.e. the use of the hand to touch the individual's own face, was studied in monkeys, apes and man with the object of examining which hand is used and which part of the face is touched. monkeys show little if any face touching. gorillas, orang- utans and chimpanzees show face-touching comparable to man. left-hand face touching was superior to right-hand touching for both apes and humans. one feature which distinguished humans from other apes was the frequency of ch ... | 1984 | 6427652 |
| additional evidence for more than one agent of human non-a, non-b hepatitis. transmission and passage studies in chimpanzees. | evidence supporting the existence of two agents of human non-a, non-b hepatitis was obtained by the inoculation of chimpanzees sequentially with serum from a chronically infected human (inoculum i) and with fibrinogen prepared from pooled plasma (inoculum iv), each of which had transmitted non-a, non-b hepatitis to humans. passage inoculations of serum samples obtained during the acute stages of chimpanzee infections transmitted by either the agent in inoculum i or iv also transmitted non-a, non ... | 1984 | 6427990 |
| the phylogeny of the hominoid primates, as indicated by dna-dna hybridization. | the living hominoid primates are man, the chimpanzees, the gorilla, the orangutan, and the gibbons. the cercopithecoids (old world monkeys) are the sister group of the hominoids. the composition of the hominoidea is not in dispute, but a consensus has not yet been reached concerning the phylogenetic branching pattern and the dating of divergence nodes. we have compared the single-copy nuclear dna sequences of the hominoid genera using dna-dna hybridization to produce a complete matrix of delta t ... | 1984 | 6429338 |
| electron microscopic evidence of non-a, non-b hepatitis markers and virus-like particles in immunocompromised humans. | characteristic pathological alterations of the liver in chimpanzees inoculated with non-a, non-b hepatitis sera have been described, but no corresponding findings have been reported in humans. electron microscopic studies of the liver biopsy specimens of two homosexual patients with acquired immune deficiency syndrome, one without hepatitis (patient 1) and one with chronic active hepatitis in remission (patient 2), revealed the cytoplasmic tubular structures which are characteristic of chimpanze ... | 1984 | 6430774 |
| reduction in risk of hepatitis transmission by heat-treatment of a human factor viii concentrate. | a human factor viii concentrate containing both a non-a, non-b hepatitis agent and 300 or 30,000 chimpanzee infectious doses of added hepatitis b virus (hbv) was heated to 60 c in the lyophilized state for more than 10 hr. none of the four test chimpanzees that received the heated concentrate developed biochemical or ultrastructural evidence of non-a, non-b hepatitis, whereas both control animals receiving unheated product acquired the disease four to five weeks after infusion. in one of these a ... | 1984 | 6432922 |
| comparative immunocytochemical study of the subcommissural organ. | the subcommissural organs (sco) of 76 specimens belonging to 25 vertebrate species (amphibians, reptiles, birds, mammals) were studied by use of the immunoperoxidase procedure. the primary antiserum was obtained by immunizing rabbits with bovine reissner's fiber (rf) extracted in a medium containing edta, dtt and urea. antiserum against an aqueous extract of rf was also produced. the presence of immunoreactive material in cell processes and endings was regarded as an indication of a possible rou ... | 1984 | 6435876 |
| susceptibility of hepatitis b virus to disinfectants or heat. | using direct chimpanzee inoculation as an assay method, we tested the abilities of the following chemical or physical treatments to inactivate hepatitis b virus in human plasma: 1% aqueous glutaraldehyde at 24 degrees c for 5 min, 0.1% aqueous glutaraldehyde at 24 degrees c for 5 min, 80% ethyl alcohol at 11 degrees c for 2 min, and heat at 98 degrees c for 2 min. all treatments were shown to be effective, indicating that the resistance level of the hepatitis b virus is not extreme. | 1984 | 6436295 |
| apolipoprotein a-i of primates. | monkey apoa-i was isolated by ultracentrifugation or immunoprecipitation and analyzed by isoelectric focusing and two-dimensional polyacrylamide gel electrophoresis. the plasma apoa-i of 26 old world monkeys (12 cynomolgus and 14 rhesus), 40 new world monkeys (8 cebus, 8 squirrel, 8 spider, 8 owl, and 8 marmosets), 6 prosimians (lemurs) and 10 apes (5 gibbons and 5 chimpanzees) were compared with each other as well as with human apoa-i. these analyses showed that monkey apoa-i contained one majo ... | 1984 | 6436418 |
| [electron microscopy findings in non-a, non-b hepatitis]. | contrary to some reports electron microscopy up to now has not yielded any characteristic or specific changes of liver parenchyma in hepatitis non-a-non-b of man. in man as well as in chimpanzees intranuclear particles of 20-27 nm diameter (interchromatin granula) have been found; however, they are unspecific. in chimpanzees characteristic changes of cytoplasma (type i-iv) have been demonstrated; however, there is no equivalent of that in human liver tissue to be observed. | 1984 | 6436604 |
| an alternative method of estimating the cranial capacity of olduvai hominid 7. | the cranial capacity of olduvai hominid 7 is estimated to be 690 cc, with a standard uncertainty range of 538 to 868 cc. the estimate is derived from a systematic consideration of the relationships between bregma-asterion chords and cranial capacities obtained from a large sample of homo sapiens and pan troglodytes and from available fossil hominids. the estimation technique is applicable to other characters and specimens. | 1984 | 6437236 |
| comparison of research cost: man--primate animal--other animal models. | the costs of research in human subjects are compared to those in primate animals and in other animal models on the basis of data available from a u.s. institution. the cost of experimentation in a chimpanzee is 3.59% of the per diem cost of clinical research in man. the cost for the dog is 37.1% of that of the chimpanzee, and the mouse costs 2.02% of the cost of the dog. | 1983 | 6438331 |
| epidemic non-a, non-b hepatitis in nepal. recovery of a possible etiologic agent and transmission studies in marmosets. | an epidemic of non-a, non-b hepatitis occurred in kathmandu valley, nepal, during 1981-1982, with approximately 7.6% of households and 1.4% of individuals affected. cases occurred preponderantly in the 15- to 34-year-old age group (70%), with most cases (75%) occurring in males. a high mortality rate (21%) occurred in pregnant women admitted to the hospital. no single water source was implicated, but epidemic peaks occurred during monsoon rains, and multiple opportunities for enteric transmissio ... | 1984 | 6438353 |
| the distribution of serum high density lipoprotein subfractions in non-human primates. | the ultracentrifugal flotation patterns in 1.2 g/ml solvent and ultracentrifugal gradient distribution of high density lipoproteins (hdl) from the primates--human, apes and monkeys--were determined, with emphasis on the gorilla species of apes and rhesus monkeys. diets for non-human primates were commercial chow, which is low in cholesterol. molecular weights and protein, cholesterol, phospholipid and triglyceride compositions of various density fractions were determined on human, gorilla and rh ... | 1984 | 6438429 |
| serological analysis of ureaplasmas isolated from various animals. | ureaplasmas from various animal species were serologically characterized by the growth inhibition test as well as by the metabolism inhibition test. the animals positive for ureaplasmas included 9 common squirrel monkeys, 9 green monkeys, 164 cynomolgus monkeys, 58 chimpanzees, 73 goats, 11 sheep, 102 dogs, 116 cats, 64 cattle, 290 chickens, 3 red jungle fowls and 5 japanese bantams. simian ureaplasmas were divided into four serogroups in accordance with the zoological classification of the prim ... | 1984 | 6439681 |
| phylogeny, neoteny and growth of the cranial base in hominoids. | this study tests the hypothesis that there is a general pattern in the growth of the cranial base of homo sapiens that is 'essentially neotenous' [gould, 1977]. juvenile and adult crania of homo sapiens, gorilla gorilla, pan troglodytes and pongo pygmaeus were studied and the cross-sectional growth curves for 10 measurements made on the cranial base (as viewed in norma basilaris) were compared. the results of this study suggest that relatively simple modifications to the timing or pattern of gro ... | 1984 | 6440838 |
| [non-a, non-b hepatitis. a progress report]. | the present state of the art in non-a, non-b hepatitis is reviewed. eight years of world-wide efforts in research have not yielded a definite characterization of agent(s) and markers of this viral infection. diagnosis is therefore established mainly by exclusion of the hepatitis viruses a and b, epstein-barr virus and cytomegalovirus, and drug-induced liver disease. currently available serological, electron microscopic, immune electron microscopic and clinical information on non-a, non-b hepatit ... | 1983 | 6443590 |
| structure and evolution of human y chromosome dna. | two repeated sequences account for 70% of the dna of the human y chromosome. they are located in the heterochromatin of the long arm. these sequences are related to others found on human chimpanzee and gorilla autosomes, and on the human x chromosome but have diverged in a characteristic way from the non y copies. they have no detectable phenotypic effect when translocated to autosomes. we have cloned dna from the human y chromosome using fluorescence activated cell sorting. at least one single ... | 1983 | 6444175 |
| andrenarche and its relationship to the onset of puberty. | during normal human sexual development the adrenal gland undergoes a maturational process, termed adrenarche, which results in increased adrenal secretion of androgens and estrogens. adrenarche begins several years before the onset of gonadal maturation and correlates with the appearance of the adrenal reticular zone. in normal puberty, adrenarche and gonadarche (gonadal maturation) are closely linked, but in pathological situations adrenarche can occur without gonadarche, and gonadarche without ... | 1980 | 6445284 |
| mixed lymphocyte reactivity in chimpanzees. i. some technical and genetic aspects. | one-way mixed lymphocyte culture (mlc) tests were performed among the members of five chimpanzee harems in all possible combinations: parents, parent-child, siblings and half-siblings. the technical aspects of mcl testing in chimpanzees appeared to be very similar to those observed for human and rhesus monkey mlc's. two unexpected observations were made for which no satisfactory explanation can as yet be give: firstly, the occurrence of animals with consistently high autologous values and second ... | 1980 | 6451051 |
| immunotherapy of murine leukemia. v. protection against friend leukemia virus-induced immune complex glomerulonephritis by passive serum therapy. | the development of immune complex glomerulonephritis in dba/2 mice infected with friend murine leukemia virus (f-mulv) was compared with that in mice protected against virus-induced disease by administration of chimpanzee anti-f-mulv antiserum (caf-mulv). morphologic analysis of glomeruli from viremic (infected) normal chimpanzee serum-treated animals revealed significant renal disease within 2 weeks following virus inoculation, with glomerular immune complex deposits and c-type viral particles ... | 1981 | 6456369 |
| live recombinant vaccinia virus protects chimpanzees against hepatitis b. | hepatitis b virus (hbv) is an important human pathogen responsible for over 200 million cases of chronic infection, many of which progress to hepatocellular carcinoma. although hbv cannot be propagated in tissue culture, highly effective subunit vaccines obtained from the plasma of chronically infected patients have been developed and licensed. such vaccines are safe but their expense and limited quantities make them unavailable to most third world countries. other approaches to vaccine construc ... | 1984 | 6472464 |
| chimpanzee serum lipoproteins. isolation, characterisation and comparative aspects of the low density lipoprotein and apolipoprotein-bh. | evaluation of the serum lipoprotein profile in non-fasting, adult chimpanzees by analytical ultracentrifugation revealed a lower mean ldl level (269 mg/dl) than typical of man. the major molecular form(s) of low density lipoprotein (ldl) was then isolated in the density interval 1.024-1.050 g/ml by sequential ultracentrifugation. the physicochemical properties of chimpanzee ldl, including net surface charge as judged by electrophoresis, molecular size (220 a) by electron microscopy, and chemical ... | 1984 | 6477668 |
| cardiac startle and orienting responses in the great apes. | cardiac patterns of startle and orienting in response to auditory and vibrotactile stimuli were investigated in the infant chimpanzee and gorilla. results revealed a notable cardiac acceleration in response to the initial presentations of stimuli of either modality. this acceleratory response appeared to reflect the cardiac correlate of startle and was closely associated with the elicitation of somatic startle responses. this initial cardiac acceleration was subject to rapid habituation and was ... | 1984 | 6487420 |
| binding specificities of eight monoclonal antibodies to human glycophorin a--studies with mcm, and mken(uk) variant human erythrocytes and m- and mnv-type chimpanzee erythrocytes. | four newly derived mouse monoclonal antibodies to human glycophorin a are described. three of these antibodies bind preferentially to the n form of glycophorin a; the fourth recognizes a shared determinant of the m and n forms. all four antibodies are directed toward the 39 amino acid, amino-terminal portion of the protein, and the n-specific antibodies require for binding the presence of n-acetyl-neuraminic acid on the glycosidically linked oligosaccharides. cross-reaction of the n-specific ant ... | 1984 | 6491283 |
| occurrence of ausab test positivity unrelated to prior exposure to hepatitis b virus. | positive ausab test results in the absence of all other serological markers for hepatitis b have been seen frequently in serial serum specimens from quarantined chimpanzees. in this study the responsible reactant was found to be similar to igm in terms of both size and charge. after the inoculation of hepatitis b virus, ausab-positive and ausab-negative chimpanzees were found to be equally susceptible to hepatitis b infection. thus, the presence of this reactant did not confer immunity to hepati ... | 1984 | 6491378 |
| erv3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. | a full-length human endogenous provirus termed erv3 was isolated from a human fetal recombinant dna library by low stringency hybridization with two probes: baboon endogenous virus ltr; and a pol-env subclone from the endogenous chimpanzee provirus, ch2. dna sequencing within the clone and comparisons with other retroviruses revealed that erv3 contains gag and pol gene sequences that are significantly related to those of mammalian type c retroviruses and previously described human endogenous pro ... | 1984 | 6495650 |
| evidence of hypertrophic pulmonary osteoarthropathy in a chimpanzee, pan troglodytes. | dissection of a chimpanzee has revealed the association of an intrathoracic disease (probably coccidioidomycosis) with periosteal lesions that are restricted almost entirely to the appendicular skeleton and are distributed with bilateral symmetry. these pathological conditions are compatible with a diagnosis of hypertrophic pulmonary osteoarthropathy. | 1984 | 6502686 |
| research costs: man versus chimpanzee. | | 1984 | 6502692 |
| the tail of the mansonella streptocerca microfilaria. | morphological studies of stained mansonella streptocerca microfilariae from the skin of man and chimpanzees in west africa revealed that the tail is bifid rather than blunt. this feature may be useful in characterization of related species. | 1984 | 6507737 |
| a vocabulary test for chimpanzees (pan troglodytes). | chimpanzees can communicate in american sign language (asl) to independent human observers whose only source of information is the asl signs of the chimpanzees. a vocabulary test was presented to 4 cross-fostered chimpanzees (4-6 years old). thirty-five-millimeter color slides were projected on a screen that could be seen by the chimpanzee subject but not by the human observers. there were two observers: o1 was the questioner in the testing room with the subject; o2 was in a different room. neit ... | 1984 | 6509904 |
| ureaplasmas as a cause of disease in man and animals: fact or fancy? | there is reluctance by some to regard ureaplasmas as a cause of nongonococcal urethritis in men largely because the organisms may also be found in healthy persons. could they be no more than passengers in disease? a review of past work suggests that this is not likely, a notion supported by the results of more recent studies. in certain other human diseases, such as urethritis and arthritis in hypogammaglobulinemic patients, the pathogenicity of ureaplasmas appears beyond question. in a variety ... | 1984 | 6511361 |
| luteinizing hormone and gonadal steroid levels during the menstrual cycle of orangutans. | serum luteinizing hormone (lh), progesterone, 17 beta-estradiol, and testosterone were measured during a single cycle each of five female orangutans, and urinary lh was measured in four of those cycles. midcycle peaks in lh and luteal phase elevations in progesterone (5.7-13.8 ng/ml) suggested that the cycles were ovulatory. 17 beta-estradiol was elevated at midcycle (163-318 pg/ml) and during the luteal phase (56-136 pg/ml) and testosterone was also elevated at midcycle (143-580 pg/ml). these h ... | 1984 | 6520860 |
| [cutaneous achromia and malignant melanoma]. | a cutaneous depigmentation occurring either far, or the primary tumour, or about the excision scar, or appearing in different other conditions was noted 29 times among 500 cases of malignant melanoma. before excision, a vitiliginous depigmentation was present only in two patients. nevertheless 9 patients observed a vitiligo after surgical excision of the tumour (2.5 years after, as an average) this proportion must conjecturally increase thereafter and so represent a minimal score. twice, an achr ... | 1984 | 6524818 |
| intraepithelial inclusions resembling human biondi bodies in the choroid plexus of an aged chimpanzee. | complex intracellular inclusion bodies of the biondi type were observed in the choroidal epithelium (choroid plexus of the lateral ventricle) of a 43-year-old male chimpanzee. the specific components of these inclusions are bundles of filaments 8-15 nm in diameter, which are associated with lipid droplets and a wide variety of unidentified inclusions of differing electron density. biondi bodies are characteristic inclusions of the choroid plexus of aged humans but have been claimed to be absent ... | 1984 | 6538460 |
| [inactivation of viruses in factor xiii concentrate by pasteurization]. | the use of a pasteurization step (heating in solution to 60 degrees c for 10 h) makes it possible to inactivate viruses, thus increasing the safety of the preparations. using factor xiii concentrate solution, it can be shown that hepatitis b virus and 10 other virus species are inactivated. pasteurized factor xiii was produced from starting material containing a total of 10(5.7) cid50 hepatitis-b virus (10(3.5) cid50/ml; cid = chimpanzee infectious dose). this factor xiii preparation was injecte ... | 1984 | 6543127 |
| segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in xenopus oocytes. identification of an ovalbumin signal sequence. | the intramolecular signals for chicken ovalbumin secretion were examined by producing mutant proteins in xenopus oocytes. an ovalbumin complementary dna clone was manipulated in vitro, and constructs containing altered protein-coding sequences and either the simian virus 40 (sv40) early promoter or herpes simplex thymidine kinase promoter, were microinjected into xenopus laevis oocytes. the removal of the eight extreme n-terminal amino acids of ovalbumin had no effect on the segregation of ovalb ... | 1984 | 6543229 |
| in vitro fibrinolytic activity of recombinant tissue-type plasminogen activator in the plasma of various primate species. | the ratio of fibrinolytic to fibrinogenolytic effect of recombinant human tissue-type plasminogen activator was investigated at several concentrations in an in vitro system consisting of 125i-fibrin labeled autologous plasma clots immersed in the plasma of several different primate species. a concentration-dependent fibrinolysis was obtained in each case; however, the degree of fibrinolysis differed markedly from one primate species to the other. at a concentration of 30 iu/ml (300 ng/ml) of rec ... | 1984 | 6543405 |
| [contraceptive agents for men]. | contraceptive drugs for men can control fertility by interrupting the process of spermatogenesis, preventing the maturation of spermatozoids, acting on the transportation of sperm, and by producing specific antispermal antibodies (immunologic fertility control). the effect of various steroid and nonsteroid substances on the process of spermatogenesis has been studied. a combination of gestagens and androgens has been studied as a basis for male contraception. the latest publication by m. kuhl ... | 1984 | 6544022 |
| immunotherapy of murine leukemia. ix. the requirement for the fc portion of antibody for successful passive serum therapy of friend leukemia virus-induced disease. | the possible role of an antibody-dependent cellular cytotoxicity (adcc)-type mechanism in the passive serum therapy of friend leukemia virus (flv)-induced erythroleukemia has been investigated by determining whether successful serum protection requires an intact fc portion on the administered antibody. f(ab')2 fragments of igg extracted from chimpanzee anti-flv and goat anti-flv gp71 antisera were prepared and compared with whole serum and uncleaved igg for their capacity to protect dba/2 mice a ... | 1983 | 6573816 |
| [electrophoretic polymorphism of proteins and the genetic divergence of primates]. | the hypothesis suggesting that genetic distances between primate taxa are smaller than characteristic genetic distances between non-primate taxa having the similar level of phylogenetic affinity, due to the specific features of primate protein evolution, has been probed. to this end, genetic distances between green and rhesus monkeys representing different genera of one subfamily, and between humans and chimpanzees representing related families, have been calculated and compared. it has been sho ... | 1983 | 6574096 |
| transmission of the hepatitis b virus-associated delta agent to the eastern woodchuck. | delta agent of human origin was inoculated into four woodchucks chronically infected with woodchuck hepatitis virus (whv). the animals developed delta infections with serologic patterns similar to those previously observed in human and chimpanzee infections. delta antigen was detected transiently in serum and liver and was followed by seroconversion to anti-delta antibody. analogous to the chimpanzee model of delta infection, serum and hepatocyte markers of whv were suppressed in the woodchuck d ... | 1984 | 6585793 |
| orientation of occlusal contacts in the chimpanzee, pan troglodytes verus, deduced from scanning electron microscopic analysis of dental microwear patterns. | analysis of dental microwear may be used to detect species differences in diet and to secure information about occlusal relationships and biomechanics of the jaw. microscratch-orientation data evaluated with reference to several hypotheses about functional, wear-related, sex and age influences on occlusal contacts indicated significant effects of facet type on scratch orientation, with less marked and sometimes paradoxical effects of molar wear and sex. age per se seemed not to be related to scr ... | 1984 | 6594090 |
| structure and evolution of human and african ape rdna pseudogenes. | we discuss the evolutionary significance of four aberrant 18s rdna clones that were obtained from human, chimpanzee, and gorilla dna libraries. we show that these clones carry representatives of a small 18s rdna pseudogene family that arose in a common ancestor of these species. aspects of their structure and phylogenetic distribution suggest that the 18s pseudogenes no longer interact genetically with normal ribosomal genes and therefore may not be linked to nucleolus organizer regions. | 1983 | 6599961 |
| individual and evolutionary variation of primate ribosomal dna transcription initiation regions. | a 16-kilobase region surrounding the transcription initiation site for ribosomal dna and including the entire ribosomal dna transcription unit has been characterized in man and compared in higher primates. restriction analysis of ribosomal dna from the pygmy chimpanzee (pan paniscus), the common chimpanzee (pan troglodytes), the gorilla (gorilla gorilla), the orangutan (pongo pygmaeus), the gibbon (hylobates lar), and the rhesus monkey (macaca mulatta) allows a primate phylogeny to be constructe ... | 1984 | 6599965 |
| detection of serum antibodies to adult t-cell leukemia virus in non-human primates and in people from africa. | the distribution of serum antibodies to adult t-cell leukemia virus (atlv) was examined as a marker for virus infection among non-human primates as well as people from africa and germany. the virus is present in africa in certain primate species including man. altogether, 468 sera from 27 monkey species were examined. only african green monkeys, less frequently also chimpanzees and crab-eating monkeys, were found to be infected. about 1-2% of people from kenya have antibodies, while atlv-antibod ... | 1983 | 6604034 |
| determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes. | a hybrid gene containing 182 codons of escherichia coli beta-lactamase at the amino terminus of the corresponding protein and 141 codons of alpha-globin at the carboxyl terminus was generated by inserting chimpanzee alpha-globin cdna into the pst i site of plasmid pbr322. rna transcribed in vitro from this plasmid gave a corresponding hybrid protein in a wheat germ cell-free translation system. the hybrid protein was protected from tryptic digestion and the pre-beta-lactamase signal peptide was ... | 1984 | 6607473 |
| a study of the susceptibility of three species of primate to vaginal colonization with gardnerella vaginalis. | in an attempt to develop an animal model of gardnerella-associated vaginitis, several strains of gardnerella vaginalis were inoculated into the lower genital tract of female pig-tailed macaques, tamarins and chimpanzees. g. vaginalis was not recovered from either tamarins or chimpanzees, but was recovered from each of 1o pig-tailed macaques inoculated with either of two freshly isolated gardnerella strains, colonization persisting for 11-39 days. examination of gram-stained vaginal smears obtain ... | 1984 | 6611168 |
| signals regulating hepatitis b surface antigen transcription. | about 200 million people are chronic carriers of hepatitis b surface antigen (hbsag), but since hepatitis b virus (hbv) cannot be propagated in vitro, hbsag transcription has been studied only in cell lines containing hbv dna integrated into chromosomes, and hbsag-related mrnas 2.0 to 2.5 kilobases (kb) long have been described. we have analysed the transcripts produced in an infected chimpanzee liver and in a rat cell line containing hbv dna. in contrast to previous suppositions we report here ... | 1983 | 6621688 |
| notes on the morphology of the chimpanzee and orang-utan placenta. | the placentae of 11 chimpanzees and five orang-utans were collected from japanese zoos immediately after delivery and were examined according to the methods routinely used for the human placenta. placenta extrachorialis (circumvallate and circummarginate placenta) occurred in 80 per cent of the specimens collected from each species. in both groups, the placental vessels were distributed predominantly in the magistral pattern, and the umbilical cord was eccentrically inserted. subchorionic fibrin ... | 1983 | 6622432 |
| contributions to the optimal use of human blood. ix. elimination of hepatitis b transmission by (potentially) infectious plasma derivatives. | investigations were performed concerning the elimination of the risk of hepatitis b transmission of potentially infectious plasma derivatives by the addition of a low dose of hepatitis b immunoglobulin (hbig). to this end, clotting factor viii concentrate, prothrombin complex, c1 esterase inhibitor concentrate, plasminogen and antithrombin iii were prepared from plasma strongly positive for hepatitis b surface antigen (hbsag). to one half of every preparation, hbig was added up to a final concen ... | 1983 | 6624009 |
| acquired preferences for piquant foods by chimpanzees. | humans frequently develop likings for innately unpalatable substances, while this occurs very rarely in non-humans. in this study, we establish a preference for crackers seasoned with chili pepper in two domesticated chimpanzees. chimps were offered a series of increasingly piquant crackers by their caretaker, and gradually came to prefer these crackers to unseasoned crackers. the preferences were stable over months, and generalized to a different piquant cracker. available evidence suggests tha ... | 1983 | 6625565 |
| inactivation of hepatitis b virus by intermediate-to-high-level disinfectant chemicals. | in five separate tests, hepatitis b virus in dried human plasma was exposed for 10 min at 20 degrees c to disinfectant chemicals having activity levels ranging from intermediate (e.g., 70% isopropyl alcohol) to high (e.g., 2% aqueous glutaraldehyde at ph 8.6). five chimpanzees (one animal per disinfectant chemical) received treated material intravenously, and none showed signs of infection after post-inoculation periods of 9 months. two animals were rechallenged with inoculum treated in the same ... | 1983 | 6630443 |
| a monoclonal antibody to rhesus erythrocyte band 3 inhibits invasion by malaria (plasmodium knowlesi) merozoites. | receptors on erythrocytes and malaria parasites mediate specific attachment and junction formation between these cells that lead to invasion of the erythrocytes. we identified monoclonal antibody a9 and its subclone a9d3 that bound to rhesus erythrocytes and blocked invasion of the erythrocytes by plasmodium knowlesi merozoites. the monoclonal antibodies did not block attachment, the initial step in invasion, although swelling and crenation of the erythrocyte, which normally occur after attachme ... | 1983 | 6630511 |
| effects of uricosuric drugs and diuretics on uric acid excretion in oxonate-treated rats. | a practical procedure for evaluating uricosuric agents was demonstrated using clearance experiments with potassium oxonate-treated rats. the fractional excretion value of uric acid showed a reabsorptive net flux of uric acid in the renal tubules of the animal, though the value was obviously higher than those of primates such as men, chimpanzees and cebus monkeys. however, the rats responded well to uricosuric drugs and diuretics. probenecid and uricosuric diuretics such as tienilic acid induced ... | 1983 | 6645117 |
| hepatitis b after infection of a chimpanzee with cloned hbv dna. | transfection of chimpanzee liver cells in vivo or in vitro with cloned hbv dna induced typical hepatitis b in the inoculated animal. intravenous inoculation of a 1000-fold greater dose of the same cloned hbv dna did not induce infection or disease. the experiment proved that cloned hbv dna is fully functional and that the nick gap structure, proteins covalently linked to the hbv genome, or any other hbv particle associated protein are not needed for initiation of virus replication. | 1983 | 6653885 |
| hepatic fibrosis in schistosoma haematobium-infected mice. | swiss mice were exposed subcutaneously to 270 to 500 schistosoma haematobium cercariae and killed 13 to 52 weeks later. less than 10% of applied cercariae were recovered as worms, and the rate of oviposition by adult worm pairs was generally low. however, the adult worms survived well, the females contained an average of 56 eggs one year after infection, and numerous mature eggs were present in the tissues. all worms were located in the portal venous system. s. haematobium eggs in the liver elic ... | 1983 | 6659047 |
| [comparative anatomy of the mandible. functional aspects]. | the structural morphology of the mandibula is presented and correlated to various types of mastication in several mammalian species. the latter include: carnivores (dog, cat, cheetah, lion); omnivores (man, chimpanzee, hog); herbivores (horse, ox, goat, camel, rabbit). while the mandibula is studied as a composite unit, a more analytical, segmental approach has been included, and both are illustrated by x-rays. the aspects presented underline the distribution as well as the local modifications o ... | 1983 | 6679450 |
| structural and evolutionary analysis of the two chimpanzee alpha-globin mrnas. | two distinct alpha-globin mrnas were detected in chimpanzee reticulocyte mrna using a primer extension assay. dna copies of these two mrnas were cloned in the bacterial plasmid pbr322, and their sequence was determined. the two alpha-globin mrnas have obvious structural homology to the two human alpha-globin mrnas, alpha 1 and alpha 2. comparison of the two chimpanzee alpha-globin mrnas to each other and to their corresponding human counterparts revealed evidence of a recent gene conversion in t ... | 1983 | 6689503 |
| identification and quantitation of steroids in sulfate fractions from plasma of pregnant chimpanzee, orangutan, and rhesus monkey. | steroids in the mono- and disulfate fractions from plasma of pregnant chimpanzees (pan troglodytes), orangutans (pongo pygmaeus), and a rhesus monkey (macaca mulatta) were identified by gas chromatography/mass spectrometry and quantitated by gas-liquid chromatography on open tubular glass capillary columns. whereas the average total concentrations were 4-5 times lower, 2.3-5.5 mumol x 1(-1) vs. 10.7-19.8 mumol x 1(-1), the pattern of steroid sulfates in the chimpanzees and orangutans were very s ... | 1984 | 6690281 |
| delta hepatitis agent: structural and antigenic properties of the delta-associated particle. | delta agent (delta) was serially passaged to a second and third hepatitis b surface antigen (hbsag) carrier chimpanzee, using as inoculum the peak delta antigen (delta ag) serum of an animal previously infected with human serum. the characteristics of serially transmitted delta ag were similar to those described in first-passage animals. it was consistently detected before the development of anti-delta, in association with a 35- to 37-nm subpopulation of hbsag particles and a unique low-molecula ... | 1984 | 6698598 |
| species identification of blood and saliva stains by enzyme-linked immunoassay (elisa) using monoclonal antibody. | an indirect enzyme-linked immunoassay (elisa) method for the identification of human blood and saliva stains is reported. the method uses a monoclonal antibody which reacts with human immunoglobulin g (igg) in extracts of blood and saliva stains up to 16 months old. semen stain extracts gave weak or negative results. for routine screening purposes dilutions of 1:1000 for bloodstain extracts and 1:100 for saliva stain extracts would be suitable. of 32 other animal species tested, only chimpanzee, ... | 1984 | 6699607 |
| 'insight' in the pigeon: antecedents and determinants of an intelligent performance. | in 1917 wolfgang köhler reported some rather extraordinary instances of problem solving by a number of chimpanzees, and his observations have been the subject of controversy ever since. the period of quiescence that sometimes preceded the solution, its sudden onset, and its smooth, continuous emergence were proffered as evidence that (1) contrary to suggestions of learning theorists of the day, problem solving was not necessarily a trial-and-error process, and (2) constructs such as 'insight' we ... | 1984 | 6700713 |
| pathology of hepatitis a infection in the owl monkey (aotus trivirgatus). | sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis a virus (hm-175 or pa-33) were examined for histopathologic alterations. preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts and hepatic lobular parenchyma. histopathologic features that were present in biopsies taken during the period of elevated serum alanine aminotransferase activity (16-43 days after the intravenous ino ... | 1984 | 6711675 |
| acute hepatitis a infection in hepatitis b chimpanzee carriers. | two hepatitis b virus carrier chimpanzees which were superinfected with hepatitis a virus developed acute hepatitis followed by the production of antibodies to hepatitis a virus. the southern blot technique employed to monitor liver hepatitis b virus dna revealed that the amount of viral dna in both animals was significantly reduced during the acute phase of hepatitis a infection. the levels of plasma hepatitis b dna polymerase activity were also reduced in one chimpanzee. the high titers of hbs ... | 1984 | 6724518 |
| a dna fragment from the human x chromosome short arm which detects a partially homologous sequence on the y chromosomes long arm. | an x linked human dna fragment (named dxs31 ) which detects partially homologous sequences on the y chromosome has been isolated. regional localisation of the two sex linked sequences was determined using a panel of rodent-human somatic cell hybrids. the x specific sequence is located at the tip of the short arm ( xp22 .3-pter), i.e. within or close to the region which pairs with the y chromosome short arm at meiosis. however the y specific sequence is located in the heterochromatic region of th ... | 1984 | 6728677 |
| nasal polyposis in a chimpanzee. | a 15-year-old female chimpanzee with nasal polyposis sustained respiratory compromise when she was sedated and expired despite resuscitative efforts. postmortem examination revealed very large fibromyxomatous nasal polyps completely obstructing the upper airway. gross examination and histopathologic findings were indistinguishable from those of human polyps. the chimpanzee is a potential animal model for nasal polyposis that could provide basic information concerning the relationship of polyps t ... | 1984 | 6736484 |
| dna: dna hybridization method for the diagnosis of hepatitis b infection. | hepatitis b viral (hbv) dna was detected in a hepatoma cell line which produces hepatitis b surface antigen (hbsag) and in patients with acute hepatitis b. the serum of one patient with acute hepatitis b was found to be infectious when injected i.v. into a chimpanzee up to a dilution of 10(-8). hepatitis b surface antigen (hbsag) and hepatitis b e antigen (hbeag) were detectable in the same serum sample by radioimmunoassay up to a dilution of 10(-5) and of 10(-3), respectively. using dna: dna hy ... | 1984 | 6746840 |
| identification of human blood with hybridoma-derived antibody to human immunoglobulin g. | during production of monoclonal anti-gamma (gm) antibody by the hybridoma technique, an antihuman immunoglobulin g (igg) antibody was obtained. unlike conventional antihuman igg heteroantisera, this antibody reacted with the serum of humans and chimpanzees but did not cross-react with that of other primates or lower animal species in hemagglutination-inhibition tests with anti-d-coated red cells. to examine for the practical utility of the antihuman igg antibody in an enzyme-linked immunosorbent ... | 1984 | 6747588 |
| modulation of hepatitis b infection by intravenous application of an immunoglobulin preparation that contains antibodies to hepatitis b e and core antigens but not to hepatitis b surface antigen. | repeated administration of an intravenous immunoglobulin containing antibody to hepatitis b e antigen (anti-hbe) and antibody to hepatitis b core antigen (anti-hbc) but free of antibody to hepatitis b surface antigen (anti-hbs) before and after the inoculation of 10(4.9) 50% chimpanzee infective doses of hepatitis b virus (hbv) markedly prolonged the incubation period of hbv in experimentally infected chimpanzees. similar administration of an immunoglobulin preparation containing anti-hbc but fr ... | 1984 | 6748163 |
| characterization of viral genomes in the liver and serum of chimpanzee long-term hepatitis b virus carriers: a possible role for supercoiled hbv-dna in persistent hbv infection. | in chimpanzee hepatitis b virus (hbv) carriers, the molecular mechanism for viral persistence has been examined by analyzing the properties of viral dna molecules in liver and serum. two extrachromosomal hbv-dna molecules migrating on southern blots at 4.0 kb and 2.3 kb were observed in chimpanzee liver dna. there was no evidence for integration of hbv sequences into the host genome. the hbv-dna molecule which migrated at 4.0 kb position represents a full-length "nicked," relaxed circular form, ... | 1982 | 6759514 |
| bioenergetics and the origin of hominid bipedalism. | compared to most quadrupedal mammals, humans are energetically inefficient when running at high speeds. this fact can be taken to mean that human dipedalism evolved for reasons other than to reduce relative energy cost durding locomotion. recalculation of the energy expending expended during human walking at normal speeds shows that 1) human bipedalism is at least as efficient as typical mammalian quadrupedalism and 2) human gait is much more efficient than bipedal or quadrupedal locomotion in t ... | 1980 | 6768300 |
| functional articulation of some hominoid foot bones: implications for the olduvai (hominid 8) foot. | previous observations on twelve fossil foot bones (olduvai 8: day and napier, '64) together with multivariate morphometric studies of one of them, the talus (day and wood, '68) suggested human-like bipedality for this foot. subsequent studies showed the conclusions on the talus to be wrong: the fossil talus, as defined by eight measures, does not resemble that of man but is reminiscent of those of creatures known (extant--orangutans) or believed (extinct--some fossil apes and monkeys) to be arbo ... | 1980 | 6768301 |
| an electromyographic study of the pectoralis major in atelines and hylobates, with special reference to the evolution of a pars clavicularis. | among primates there is striking variation in the extent of the origin of pectoralis major from the clavicle. a significant clavicular attachment (pars clavicularis) occurs only in alouatta, lagothrix, hylobates, pan (troglodytes, paniscus and gorilla), and homo. interpreting this trait in nonhuman primates as an adaptation to frequent use of a mobile forelimb in climbing and suspension is contraindicated by the absence of a clavicular origin in ateles and pongo. we have undertaken a telemetered ... | 1980 | 6768302 |
| origin of bipedalism. | human and chimpanzee locomotor behaviors are described and compared using field patterns derived from measurements of the motions at the joints. field patterns of human and ape bipedalism are so different that it is doubted whether the nonhuman type could ever have been a precursor of the human type. chimpanzee quadrupedal vertical climbing and human bipedalism are, on the other hand, similar and a particular variety of this kind of climbing probably was the precursor of human bipedalism. animal ... | 1980 | 6768307 |
| transmission of human non-a, non-b hepatitis to chimpanzees following failure to transmit gb agent hepatitis. | two colony-born infant chimpanzees were inoculated with documented infectious serum containing the gb agent. serum aminotransferase levels remained within normal limits in weekly serum samples, and no abnormalities were detected in weekly liver biopsy specimens. each of these chimpanzees was subsequently inoculated with serum containing an agent of human non-a, non-b hepatitis. each developed non-a, non-b hepatitis characterized by elevation of serum aminotransferase levels and histopathologic c ... | 1980 | 6768842 |
| further evidence of cellular changes associated with non-a, non-b hepatitis. | two distinct types of ultrastructural changes were found in the hepatocytes of chimpanzees infected with two forms of non-a, non-b hepatitis. in the type of infection that was of long incubation, there was a marked cytoplasmic derangement of the endoplasmic reticulum, with the formation of tubules, but no pathological changes in the nuclei. in the short-incubation type of non-a, non-b hepatitis, induced experimentally in a chimpanzee that had recovered from the long-incubation type of infection, ... | 1980 | 6770041 |
| experimental kuru in the rhesus monkey. a clinical study. | serial neurologic examinations of six rhesus monkeys inoculated with a strain of kuru revealed complex clinical signs falling into two distinct syndromes. experimental kuru in the rhesus monkey is different from the disease in man and to a lesser extent in the chimpanzee. two factors are proposed to account for these observations: modification of the strain, and specific host characteristics. | 1980 | 6771400 |
| bacteriological findings in a nonhuman primate colony. | a 5-year review (march 1974-march 1979) of bacteriological findings in old and new world primates is discussed. emphasis is on clinical findings in "sick" animals; the primary clinical problems being pneumonia, tuberculosis, intestinal disorders, and trauma infection. the isolation of infrequently encountered pathogenic organisms is discussed. nonhuman primtes included in this study are baboons (papio cynocephalus), chimpanzees (pan sp.), capuchins (cebus sp.), rhesus (macaca mulatta), marmoset ... | 1980 | 6772506 |
| blood groups : immunogenetic markers in primate animals and their use in breeding and standardization. | the importance of immunogenetics for definition and standardization of laboratory animals has been demonstrated by their successful application for breeding of laboratory mice and rats, and in planned breeding of large domestic animals. among the immunogenetic markers used, blood groups are the best known and generally considered as the most important. for close to two decades, serology and genetics of blood groups have been investigated by this laboratory in the most commonly used laboratory pr ... | 1980 | 6772509 |
| growth standards in the skeletal age of rhesus monkey (m. mulatta) chimpanzee (pan tryglodytes) and man. | various methods of age assessment in nonhuman primates of unknown gestation or chronological age are discussed. the most precise of all methods, the utilization of skeletal age (appendicular bone maturation), is described. the prenatal growth standards and age indicators of m. mulatta are discussed and compared to pan tryglodytes and man. also several post-natal growth standards comparable in m. mulatta, pan tryglodytes and man are presented. the determination of unknown age of experimental anim ... | 1980 | 6772510 |
| an open air holding system for chimpanzees in medical experiments. | chimpanzee models often impose severe mental and physical suffering on these animals. we have developed an alternative system which provides for considerably more three dimensional movement and animal-to-animal interaction. it has been used for a period of 20 months in nonexperimental and 8 months in experimental animals. presently 24 experimental animals, previously held in isolation cages for up to 4 years, are held on outside pads. animals were transferred from isolation to large outdoor cage ... | 1980 | 6772512 |
| blood groups of apes and monkeys: current status and practical applications. | two categories of blood groups, human-type and simian-type, occur in apes and monkeys and can be routinely tested by methods established for grouping human blood. abundant data have been obtained on blood groups of chimpanzees, baboons and macaques. studies of populations of animals, both feral and kept in captivity, resulted in the definition of a number of erythrocyte antigens, some of which fall into separate blood group systems. two complex chimpanzee blood group systems, v-a-b-d and r-c-e-f ... | 1980 | 6775134 |
| antistreptococcal antibodies, rheumatoid factors and haptoglobin in apes and monkeys. | sera of 157 baboons (papio hamadryas and p. anubis) 21 chimpanzees (pan troglodytes) five orang utans (pongo pygmaeus) three mountain gorillas (gorilla gorilla beringei) and three gibbons (hylobates lar lar) were examined for the content of antistreptolysin o, antidesoxyribonuclease b, for the presence of rheumatoid factors as well as for the level and type of haptoglobin. the mean antistreptolysin o titer (ast) in baboons was 106 asu +/- 18 in dextransulfate absorbed sera ("real" ast) and 182 a ... | 1980 | 6775442 |
| viruslike particles in a plasma fraction (fibrinogen) and in the circulation of apparently healthy blood donors capable of inducing non-a/non-b hepatitis in humans and chimpanzees. | two patients who had received a fibrinogen preparation contracted hepatitis of non-a/non-b etiology 3 and 8 wk after the injection. a chimpanzee inoculated with the same preparation developed hepatitis 11 wk later, with an increase in sgpt and a liver pathology compatible with acute viral hepatitis. his preacute serum containing the presumptive etiologic agent induced hepatitis in another chimpanzee. electron microscopic observation of the liver of these chimpanzees biopsied during preacute and ... | 1980 | 6776003 |
| chimpanzee r-c-e-f blood group system: a counterpart of the human rh-hr blood groups. | a chimpanzee blood group system is defined by a set of isoimmune antisera, anti-rc, anti-cc, anti-ec, anti-fc, anti-cc and anti-cc1, that distinguish 19 blood types. population analysis of 285 unrelated animals and the study of 21 chimpanzee families support the postulated model of inheritance by 9 allelic genes. there is a close relationship between the r-c-e-f blood group system and human rh-hr blood groups as indicated by overall structural resemblance of both systems and by serological simil ... | 1980 | 6776021 |
| inactivation of an agent of human non-a, non-b hepatitis by formalin. | samples of serum (0.1 ml each) containing an agent of human non-a, non-b hepatitis of documented infectivity were incubated with formalin in a concentration of 1:1,000 at 37 c for 96 hr. three colony-born infant chimpanzees were then inoculated with this formalin-treated serum; one received a single intravenous inoculation, and two received two subcutaneous inoculations one month apart. a fourth uninoculated chimpanzee served as a control. none developed recognizable non-a, non-b hepatitis durin ... | 1980 | 6780630 |
| [non-a, non-b hepatitis : status of current knowledge (authors' transl)]. | the many studies carried out following post-transfusion hepatitis cases, not due to the a and b viruses identified to date, have provided incontestable evidence that cases with all the clinical, biochemical and histopathological characteristics of a and b hepatitis, but etiologically distinct, do exist. these have been temporarily termed "non-a, non-b" (nanb). the epidemiology, duration of incubation period and type of evolution, including the risk to evolve towards chronic hepatitis are common ... | 1980 | 6781019 |
| persistent non-a, non-b hepatitis in experimentally infected chimpanzees. | non-a, non-b (nanb) hepatitis was transmitted to six chimpanzees by intravenous inoculation of antihemophilic (factor viii) materials, acute-phase chimpanzee liver, and chronic-phase plasma obtained from two nanb hepatitis-infected chimpanzees 10 and 16 months, respectively, after their inoculation. five of six experimentally infected chimpanzees observed for more than one year demonstrated persistent or intermittent elevations in levels of serum alanine aminotransferase (alt) indicative of cont ... | 1981 | 6783708 |