| zinc deficiency: effects on brain and behavior of rats and rhesus monkeys. | | 1977 | 412269 |
| comparative sulfite metabolism in the rat, rabbit, and rhesus monkey. | | 1977 | 412276 |
| serum estradiol and progesterone during pregnancy and the status of the corpus luteum at delivery in cynomolgus monkeys (macaca fascicularis). | levels of estradiol and progesterone in peripheral serum of seven cynomolgus monkeys (macaca fascicularis) were measured from about the 30th day of pregnancy until parturition. although the pattern of each steroid in circulation differed somewhat from the respective patterns in rhesus monkeys (macaca mulatta), there were basic similarities. on the day of delivery, the corpus luteum was excised and in vitro incubation of dispersed luteal cells was performed. isolated luteal cells produced progest ... | 1977 | 412283 |
| gynecologic pathology in the rhesus monkey (macaca mulatta). ii. findings in laboratory and free-ranging monkeys. | the most prevalent findings in reproductive tracts of 38 laboratory and 17 free-ranging rhesus female monkeys were vaginitis, cervicitis, metritis, pelvic endometriosis and uterine adenomyosis. several monkeys had cervical dysplasia and one had a serous cystadenoma. the findings in the two groups were similar although prevalence for several diseases differed. there was a significant relationship between the occurrence of vaginitis, metritis, adenomyosis and endometriosis and gravidity, time sinc ... | 1977 | 412291 |
| metabolism of arylacetic acids. 2. the fate of [14c]hydratropic acid and its variation with species. | 1. (+/-)-[methyl-14c]-hydratropic acid was administered to man, rhesus monkey, cat, rabbit and fruit bat. 2. all species excreted 60-100% of administered 14c in the urine in 24 h, and unchanged hydratropic acid accounted for 0-17% of the dose. 3. in man, the urinary 14c consisted of a very small quantity (1%) of unchanged hydratropic acid with the remainder as hydratropylglucuronide. 4. hydratropylglucuronide was the major urinary excretion product in the 4 animal species, while the glycine conj ... | 1977 | 412331 |
| oral immunization of monkeys with polyvalent dysentery vaccine. | macaca mulatta monkeys were immunized orally with polyvalent boivin extract of shigella flexneri 2a, 3a, 4a, 4b, 6 and shigella sonnei. the total immumizing dose for each component was equivalent to 1.2 x 10(12) cells. after challenge with 7.5 x 10(10) cells of a virulent s. flexneri 2a strain, out of 20 immunized animals 2 developed dysentery and 4 showed mild dyspepsia; all 6 control animals became ill with dysentery. vaccination failed to influence the incidence, duration or the intermittent ... | 1977 | 412396 |
| adult monkey coronoid process after resection of trigeminal nerve motor root. | a smaller or absent coronoid process has been reported, by some investigators but not by others, in growing animals following resection of the temporalis muscle. the trauma of resection, altered function, hemorrhage, scar tissue, and changes in vascularity may have influenced the results. the purpose of this experiment was to observe in adult macaca mulatta the fully grown coronoid process after decreasing or eliminating neurofunctional activity of the temporalis muscle unilaterally without the ... | 1977 | 412408 |
| pulmonary functions in conscious and anesthetized rhesus macaques. | techniques for measurements of selected pulmonary functions for a period of 6 hours in conscious and lightly anesthetized rhesus macaques are described. among all variables measured, only higher paco2 (367 +/- 32 mm of hg) occurred in macaques breathing o2 as compared with those breathing room air. tidal volume, respiratory rate, minute volume, o2 consumption, and specific ventilation in conscious and anesthetized monkeys were not significantly different. further, respiratory and metabolic value ... | 1977 | 412444 |
| cardiovascular and hepatic responses of rhesus macaques to staphylococcal enterotoxin b. | certain cardiovascular and hepatic functions were measured for a period of 6 to 14 hours in conscious, chaired, male rhesus macaques given (intravenously (iv) or orally) staphylococcal enterotoxin b (seb). in macaques orally given seb (1 mg/kg), there was little change in the cardiovascular variables. the half-life of injected indocyanine green was apparently prolonged in macaques given seb as compared with that in the controls. however, in macaques given seb (0.05 or 1.0 mg/kg) by iv injection, ... | 1977 | 412445 |
| lymphocyte subpopulations in spontaneous disease of rhesus macaques. | the immunologic status of rhesus macaques (macaca mulatta) with naturally occurring disease was evaluated by determining the percentages of b and t lymphocytes and mitogen responsiveness of lymphocytes in peripheral blood and lymph nodes. the b lymphocytes were identified by the presence of cell surface immunoglobulin and receptors for complement. the t lymphocytes were identified by their ability to form spontaneous rosettes with sheep red blood cells. rhesus macaques with idiopathic or primary ... | 1977 | 412446 |
| human pb, human post-pb, and nonhuman primate pb proteins: immunological and biochemical relationships. | the isolation and characterization of a protein from human parotid saliva termed the "post-pb protein" is described. by several criteria, this protein is closely related to the human pb proteins. when reacted against antisera to human pb protein in double diffusion, the post-pb protein is found to be related to the pb proteins by lines of identity. however, when the partial n-terminal amino acid sequences of the post-pb protein and pb proteins are compare, the sequences are not identical. becaus ... | 1977 | 412494 |
| behavioural and pharmacokinetic studies in the monkey (macaca mulatta) with diazepam, nordiazepam and related 1,4-benzodiazepines. | 1. behavioural activity (delayed differentiation and spatial delayed alternation) and pharmacokinetics of diazepam and its metabolites, n-desmethyldiazepam (nordiazepam), 3-hydroxydiazepam (temazepam) and 3-hydroxy-n-desmethyldiazepam (oxazepam), and of dipotassium clorazepate (clorazepate), were studied in the monkey (macaca mulatta). diazepam and its metabolites (1.8 and 3.0 mg/kg) and clorazepate (2.6 and 4.3 mg/kg) were given by intraperitoneal injection. 2. hydroxylation of diazepam (temaze ... | 1977 | 412540 |
| behavioural studies in the monkey (macaca mulatta) with sotalol and with (+)-, (+/-)- and (-)-propranolol [proceedings]. | | 1977 | 412542 |
| assessment of the effectiveness of drugs to substitute for morphine in the opiate-dependent rhesus monkey [proceedings]. | | 1977 | 412543 |
| total hepatic ischaemia in the rhesus monkey. | during operations for major hepatic trauma it may be necessary temporarily to deprive the liver of its blood supply by occlusion of the hepatic artery and portal vein. the maximum 'safe period' of total hepatic ischaemia in man is unknown. in the monkey the ischaemic liver 'leaks' potassium, and levels of this element in the hepatic veins rise during ischaemia reaching a peak immediately after blood supply to the liver is restored. however, critical systemic levels of potassium are never reached ... | 1977 | 412546 |
| osmotic opening of the blood-brain barrier in the rhesus monkey without measurable brain edema. | the blood-brain barrier in the rhesus monkey was opened to intravascular evans blue-albumin, without causing brain edema or altering brain electrolytes, by perfusing 2.5 molal recrystallized d,l-lactamide into the internal carotid artery for 20--30 sec. gross neurological and behavioral sequelae were absent in 7 of 8 animals with barrier opening, and 2 days after perfusion no statistically significant changes were observed in sodium, potassium or water contents of perfused as compared to unperfu ... | 1977 | 412564 |
| shock-induced inhibition in the lateral geniculate nucleus of the rhesus monkey. | | 1977 | 412566 |
| labelling of membrane glycoprotein in erythrocytes infected with plasmodium knowlesi. | normal rhesus monkey erythrocytes and erythrocytes infected by p. knowlesi were labelled with galactose oxidase (ec 1.1.3.9) and tritiated sodium borohydride. the glycoproteins of normal erythrocytes were not labelled unless the cells were pretreated with neuraminidase, when peaks of activity with apparent molecular weights of 170 000, 126 000, 90 000, 50 000, and 35 000 were observed. schizont-infected erythrocytes showed an absence of glycoprotein labelling even after neuraminidase treatment. ... | 1977 | 412601 |
| effect of d-norgestrel on lh levels and ovulation in the rhesus monkey. | | 1977 | 412640 |
| a dose ratio comparison of the interaction between morphine and cyclazocine with naloxone in rhesus monkeys on the shock titration task. | dose-response curves for morphine (0.5-20 mg/kg) were obtained in 4 rhesus monkeys performing the discrete trials shock titration task. naloxone (5-500 microgram/kg) uniformly produced a dose dependent, parallel shift of the morphine dose-response curves to right. plots for the 4 animals of the log (dose ratio--1) versus --log (naloxone) revealed that the line had a slope of -0.96. the value of the pa2 was 7.2. similar experiments were carried out in two rhesus monkeys using cyclazocine. naloxon ... | 1977 | 412680 |
| three-dimensional architecture of the suspensory apparatus of the lens of the rhesus monkey. | | 1977 | 412688 |
| the difference in effect of predosing with antiallergic compounds between the rat pca model and the monkey asthma model. comparison of the effects of prd-92-ea and disodium cromoglycate. | dscg and prd-92-ea showed tachyphylaxis in the rat pca test when a large intravenous dose (40 mg/kg of dscg and 20 mg/kg of prd-92-ea) was given 30 min before administering intravenously the expected effective doses at the time of antigen challenge. this predosing led to a marked loss of effectiveness. cross-reacting tachyphylaxis was also demonstrated in this model. predosing rats with dscg led to a great loss of effectiveness of a subsequent expected active dose of prd-92-ea and predosing with ... | 1977 | 412794 |
| monkey glutathione s-aryltransferases. ii. properties of the major enzyme purified from the liver. | 1. the molecular and enzymatic properties of the major component (fraction iv) of glutathione s-aryltransferases [ec 2.5.1.13] purified from the liver of monkey (mainly rhesus monkey) have been investigated. the enzyme had a molecular weight of about 48,000 and was composed of two subunits of apparently identical molecular weight (ca. 24,000) bound to each other non-covalently. each subunit contained one sh group. the amino acid composition showed characteristic high contents of leucine and glut ... | 1977 | 412843 |
| the locus and cytoarchitecture of the projection areas of the olfactory bulb in macaca mulatta. | a study was made of the normal and experimental anatomy of the olfactory system of the young adult male rhesus monkey. the cytoarchitecture of the central olfactory areas was studied with cell and fiber stains, while the extent and pattern of the projections of the olfactory bulb were determined by the fink-heimer and autoradiographic methods. the brain of one animal that had sustained damage to the olfactory bulb two days prior to sacrifice, and of one that had a transection of the olfactory tr ... | 1978 | 412879 |
| characterization and measurement of an androgen receptor protein in the cytosol of rhesus monkey prostate [proceedings]. | | 1977 | 412908 |
| asphyxia-induced disaggregation of cerebral polyribosomes in rhesus monkey fetuses. | the effects of 3 hours of controlled intrauterine asphyxia (acidotic hypoxia) on the sedimentation patterns of cerebral polyribosomes and on polyribosome supported in vitro protein synthesis were examined in 16 term monkey fetuses. three outcomes resulted. four fetuses showed no changes in polyribosome sedimentation profile or in sedimented polyribosome supported in vitro protein synthesis. four showed changes in sedimentation profiles indicating partial breakdown of polyribosomes and significan ... | 1978 | 412923 |
| histopathologic evaluation of three ultraviolet-activated composite resins on monkey pulps. | the pulpal responses of three ultraviolet-activated composite resins, nuva-fil, experimental uv no. 1 and experimental uv no. 2, were tested on adult monkey teeth using silicate and zinc oxide eugenol (zoe) as positive and negative controls. all materials were placed in class v cavity preparations in rhesus monkey teeth using approximately 48 anterior and 63 posterior teeth of both the maxillary and mandibular arches. a total of 111 teeth were utilized and all materials were evaluated at 3 days, ... | 1977 | 412925 |
| effects of intravenous cocaine, diethylpropion, d-amphetamine and perphenazine on responding maintained by food delivery and shock avoidance in rhesus monkeys. | the effects of perphenazine, cocaine, diethylpropion and d-amphetamine on responding maintained by both food delivery and electric shock avoidance were determined using a multiple schedule of reinforcement in rhesus monkeys. this schedule had three components, each separated by a timeout: a fixed-ratio schedule of food delivery, a schedule of spaced responding (differential reinforcement of low rates) maintained by food delivery and a fixed-ratio schedule of shock avoidance. control rates of res ... | 1978 | 412947 |
| antischistosomal effects of 5-(2,4,5-trichlorophenyl)hydantoin and related compounds. | 5-(2,4,5-trichlorophenyl)hydantoin and several analogues effected an 80-90% reduction of live schistosomes in infected mice at doses ranging from 265 to 329 mg/kg per day when administered orally in the diet for 14 days. the sodium salt of 5-(2,4,5-trichlorophenyl)hydantoin, when given by gavage to rhesus monkeys infected with schistosoma mansoni at 200 mg/kg/day for 5 or 10 days, removed all but a few live worms with no evidence of intolerance. | 1977 | 412964 |
| cholelithiasis in a male rhesus monkey (macaca mulatta) fed a cholesterol-containing diet. | in this report we describe the development of cholelithiasis in a male rhesus monkey fed a cholesterol-containing diet for 24 months. this represents the only case of cholelithiasis in this species of nonhuman primate that we have observed out of a population of over 500 rhesus monkeys fed similar cholesterol-containing diets. associated with the appearance of gallstones was the production of bile saturated with cholesterol, and the excretion of bile with an abnormal bile acid composition. | 1977 | 412973 |
| gastric secretion with feeding and restraint in conscious rhesus monkeys. | four chair-housed rhesus monkeys (macaca mulatta) were surgically prepared with vagally-innervated fundic gastric pouches. as in man, basal acid secretion was evident in all subjects. in response to a test meal, acid output rose twofold over basal values and remained elevated up to 6 h. compared to control values, food-stimulated acid output was reduced significantly during periods of restraint. | 1977 | 412974 |
| ovulation in rhesus monkeys suppressed by intranasal administration of progesterone and norethisterone. | | 1977 | 413055 |
| a note on ecg changes observed during pavlovian conditioning in a rhesus monkey following coronary arterial occlusion. | changes in the ecg of a rhesus monkey during a classical aversive conditioning trial conducted 10 minutes after occlusion of the marginal branch of the left circumflex coronary artery have been observed. this appears to reflect an instance where myocardial ischemia following coronary occlusion was exacerbated by presentation of a conditional stimulus. | 1977 | 413087 |
| second-order schedules of intravenous drug self-administration in rhesus monkeys. | lever-pressing behavior was generated and maintained in 3 rhesus monkeys by intravenous infusions of morphine or cocaine under a second-order schedule of reinforcement. under this schedule, every tenth lever-press response (fr 10) during a fixed interval of time produced a 2 sec stimulus light. the first fr 10 completed after a 60 min interval had elapsed produced the stimulus light and an intravenous infusion of morphine or cocaine. the stimulus light remained on for the duration of the drug in ... | 1977 | 413115 |
| social interaction and serum insulin values in the monkey (macaca mulatta). | social interaction studies were conducted with two groups of rhesus monkeys with abnormally elevated serum insulin values. in both studies, the animals that were lowest on the dominance-submissiveness scale showed a fall in insulin levels to within the normal range for the monkey. upon removal from the group, insulin values in these animals returned to their previous elevated level. in neither instance was the fall in insulin level accompanied by fasting hyperglycemia. | 1977 | 413152 |
| congenital cerebral and ocular malformations induced in rhesus monkeys by venezuelan equine encephalitis virus. | rhesus monkey fetuses were inoculated with venezuelan equine encephalitis (vee) vaccine virus by the direct intracerebral route at approximately 100 days gestation to determine possible teratogenicity of the virus. congenital micrencephaly, hydrocephalus and cataracts were found in all animals and porencephaly in 67 percent of the cases. the virus replicated in the brain and other organs of the fetus. vee vaccine virus is teratogenic for non-human primates and must be considered a potential tera ... | 1977 | 413204 |
| a review of metozoite vaccination against plasmodium knowlesi malaria. | techniques for the isolation of merozoites of plasmodium knowlesi malaria have allowed their use in experimental vaccines. rhesus monkeys were protected to a very great extent from otherwise lethal challenge with this malaria when freund's complete adjuvant was a vaccine component. | 1977 | 413214 |
| mechanisms of malarial immunity. | immunity to malaria in many species, including man, is acquired only after long exposure to infection and is associated with chronic low-grade parasitaemia. vaccination of rhesus monkeys with p. knowlesi merozoites in fca induces sterilizing immunity which is species specific. merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera. however, vaccination using adjuvants other than fca may induce inhibitory ant ... | 1977 | 413215 |
| the zonal anatomy of the prostate in man and in the rhesus monkey (macaca mulatta). | study of whole sections of human prostate has confirmed mcneal's (4) concept of a dual morphology of the external glands (2) in the terms of a central zone cranially and a peripheral zone caudal to this. a study of the non-human primate, macaca mulatta, has shown cranial and caudal prostatic entities in this animal whose anatomical relationships and histological characteristics suggest homology with the central and peripheral zones of the human. | 1977 | 413235 |
| androgen receptors in the prostate of the rhesus monkey. | the presence of an androgen receptor protein in the supernatant preparation of the prostate from rhesus monkey (macaca mulatta) is described. the molecular weight of this receptor protein was found to be 2.8 - 2.9 x 10(5) daltons. the levels of free and bound androgen receptors were measured in the caudal and cranial lobes of the prostate by an exchange assay using methyltrienolone (r1881). the concentration of the free binding sites in the caudal lobe ranged between 3.7 - 23.7 fmol/mg proteial ... | 1977 | 413236 |
| the ultrastructure of rhesus monkey prostate. | an ultrastructural study of immature and mature rhesus monkey prostate is described and a comparison is made with human tissue. the immature gland consists of largely undifferentiated epithelium showing little or no secretory activity. the mature gland exhibits the general characteristics of prostates of the other species studied. columnar epithelial cells and undifferentiated basal cells are observed. the two lobes of the gland show several differences, the caudal lobe being rich in secretory g ... | 1977 | 413237 |
| alcohol withdrawal reactions in rhesus monkeys. | the magnitude of the ethanol withdrawal reaction was assessed in rhesus monkeys (macaca mulatta) following 96 hours of either constant or systematically fluctuating blood ethanol concentrations (bec) using both physiological tremor and scores on a behavioral checklist as dependent measures. although specific bec (50, 100, 200 or 300 mg/dl) were not reliably related to changes in mean frequency of tremor, this measure was a statistically significant curvilinear function of time as measured before ... | 1977 | 413338 |
| drinking of ethanol by rhesus monkeys: experimental strategies for establishing ethanol as a reinforcer. | | 1977 | 413339 |
| slow maxillary expansion: skeletal versus dental response to low magnitude force in macaca mulatta. | low-magnitude continuous force (1 to 2 pounds) was applied in a transverse direction to the palatal vault and posterior teeth of three rhesus monkeys to assess linear and angular changes of the maxilla versus those of the maxillary posterior teeth. | 1978 | 413440 |
| reversibility of cholesterol-adrenaline-induced atherosclerosis in rhesus monkeys: evaluation of safflower oil and low-fat low-calorie diet. | | 1977 | 413557 |
| characterization of the collagen chains synthesized by cultured smooth muscle cells derived from rhesus monkey thoracic aorta. | five different collagen chains and one smaller collagenous fragment have been isolated from the collagens found in the combined cell layer and medium of rhesus monkey aortic smooth muscle cell cultures. the collagen chains which can be identified are alpha1 (iii), alpha1(i), alpha2, a and b. the smaller collagenous peptide exhibits an apparent molecular weight of 45 000 and has been designated cp45 (mayne, r., et al. (1977), arch. biochem. biophys. 181, 462). smooth muscle cells continue to synt ... | 1978 | 413572 |
| fetal or maternal hypophysectomy in rhesus monkeys (macaca mulatta): effects on the development of testes and other endocrine organs. | | 1977 | 413589 |
| differential androgen uptake by the lobes of the rhesus monkey prostate. | the prostate of the rhesus monkey (mucacca mulatta) consists of a cranial and a caudal lobe. the uptake of [3h] testosterone by these 2 lobes has been measured and compared with control tissues. a significantly higher uptake of radioactivity was found in the caudal lobe when compared to cranial as well as other control tissues. the uptake of radioactivity by the caudal and cranial lobes was suppressed when unlabelled testosterone was introduced into the incubation media. the relationship between ... | 1977 | 413603 |
| the circadian variation of catecholamine metabolism in the subhuman primate. | cerebrospinal fluid (csf) was removed continuously in 2- or 3-h aliquots from the lateral and fourth cerebral ventricles of chronic chair restrained rhesus monkeys. under conditions of 12 h light (06.00-18.00 h) and 12 h darkness (18.00-06.00 h) the concentrations of norepinephrine (ne) were found to describe a circadian pattern, with maximal concentrations occurring during the light hours and minimal concentrations occurring during the dark hours. the patterns were generally coincident with the ... | 1978 | 413608 |
| cortico-striate projections in the rhesus monkey: the organization of certain cortico-caudate connections. | the organization of cortical projections to the caudate nucleus was investigated in the rhesus monkey, using the autoradiographic tracing method. following injections of tritiated leucine and proline into selected pre- and post-rolandic association areas in the frontal, parietal, occipital and temporal lobes, widespread projections were observed to one, or more typically, more than one of the major subdivisions of the caudate nucleus. when cortical areas having strong reciprocal cortico-cortical ... | 1978 | 413609 |
| retinal damage secondary to chronic light exposure, thresholds and mechanisms. | the effect upon the retina of exposure to large fields of bright visible light has been evaluated. the thresholds for permanent retinal damage for four hour exposures in rhesus monkeys have been established for white light, and laser lines of 514.5 nm, 488 nm, 457.9 nm, and 590 nm. the damage has been evaluated by ophthalmoscopy, electroretinography and light and electron microscopy. the shortest wavelength light (457.9 nm) is more effective in causing damage, particularly histological damage, w ... | 1977 | 413705 |
| vestibular responses in the rhesus monkey ventroposterior thalamus. ii. vestibulo-proprioceptive convergence at thalamic neurons. | the vestibular thalamic relay in the rhesus ventrobasal complex, identified in a previous field potential study (part i, deecke et al., 1974), has now been investigated with neuronal recordings in the thalamus in order to clarify its functional role. in part i, short latency responses (2.5 msec) were found in the corner between vpl, vpm and vpi nuclei, largely including dorsal portions of the vpi nucleus. field potentials of somewhat longer latency (4-5 msec) were recorded in vpl and in other th ... | 1977 | 413724 |
| stimulus dependent colour specificity of monkey lateral geniculate neurones. | from six flaxedilized rhesus monkeys neuronal activity of 75 cells in the dorsal, and 45 cells in the ventral layers of the lateral geniculate body was recorded. responses to large fields switched on and off, to moving slits, and to moving spots were obtained for several wavelengths. in the dorsal layers, colour selectivity was strong for large field stimuli but weak for moving spots. residual colour selectivity for spots was more evident for smaller eccentricities. in comparison, ventral layer ... | 1977 | 413725 |
| vestibular nuclei activity during optokinetic after-nystagmus (okan) in the alert monkey. | neurons which receive an input from the horizontal semicircular canals were recorded from the vestibular nuclei in chronically prepared monkeys (macaca mulatta) during optokinetic after-nystagmus (okan). in complete darkness the vestibular neurons showed activity changes which closely paralleled the strength of nystagmus. the activity of vestibular units returned to baseline levels of spontaneous discharge only when all after-nystagmus had ceased, or when it was inhibited by stationary visual st ... | 1977 | 413726 |
| [cardiac contraction frequency in macaca rhesus monkeys occupying different position in a group hierarchy]. | four variants of heart rate ratio were revealed in 8 groups of the monkeys of different hierarchic positions. dependence of the heart rate in low-ranking monkeys on the character of their interrelationships with the dominant individual, was shown. the lowest heart rate was revealed in the monkeys protected by the drominand individual. the heart rate at rest and its shifts during feeding reflect the degree of emotional tension in monkeys of different ranks. | 1977 | 413749 |
| immunological relationships of human and subhuman primate pregnancy-associated plasma proteins. | (1) four pregnancy-associated plasma proteins cross-reactive with antibodies to the human pregnancy proteins were detected in several species of pregnant subhuman primates. in the case of the two apes studied (chimpanzee and orangutan), these appeared to be immunologically identical to the human papps (papp-a, -b, -c, and hcs). in the old world monkeys analyzed, equivalent partially cross-reactive papps were found; while in the new world squirrel monkey, only faint traces of cross-reactive papp- ... | 1978 | 413796 |
| development of social behavior in an adult total isolate rhesus monkey (macaca mulatta). | a 12-year-old female total isolate rhesus monkey was pretested with age mates and subsequently housed for 20 weeks with an infant "therapist" monkey. daily observations during that period revealed a 24-fold increase in the probability of social behavior. self-directed behaviors also increased significantly. disturbance behaviors (self-slapping, self-biting, bizarre limb movements, etc.) remained unchanged. although problems obviously exist in cross-species generalization, and are here considered ... | 1977 | 413825 |
| cortico-cortical connections of somatic sensory cortex (areas 3, 1 and 2) in the rhesus monkey. | | 1978 | 413844 |
| effects of prestriate, inferotemporal, and superior temporal sulcus lesions on attention and gaze shifts in rhesus monkeys. | the role of extrastriate cortical areas in selective attention was studied in 12 rhesus monkeys. animals learned a series of color-form pattern discrimination problems, with either color or form cues relevant. after each problem was mastered, correct behavior required a shift in attention, i.e., that responses be made to be previously irrelevant dimension. on some problems shifting attention required that the animal maintain the same fixation; on other problems the color and form cues were separ ... | 1977 | 413847 |
| quantitative assessment of free gingival grafts with and without periosteum and osseous perforation. | forty free gingival grafts were performed on 5 adult rhesus monkeys as follows: 10 grafts were placed on recipient sites with periosteum; 10 grafts on periosteum and perforated cortical plate; 10 grafts on bared bone; and 10 grafts on perforated bared bone. all free autografts (7 x 5 x 1 mm) were taken from the palatal mucosa and were sutured in place. clinical evaluation and photographs were taken at 1, 2, 4, 8, 12, 16, 20 and 24 weeks postoperatively. at 24 weeks, a device was used to measure ... | 1978 | 413900 |
| continuous intravenous naltrexone effects on morphine self-administration in rhesus monkeys. | rhesus monkeys, surgically prepared with intravenous catheters, were given opportunities to self-administer morphine for 3 days, methamphetamine for 2 days and saline for 2 days in a constantly repeating cycle. access to drugs was limited to a 15-minute period every 4 hours. after stable base-line self-administration rates, saline or various concentrations of naltrexone were infused continuously through the catheter. in the first phase of the study each concentration of naltrexone was infused fo ... | 1978 | 413904 |
| synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines. | 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzazocine (1) has been synthesized via a four-step sequence from benzo-norbornadiene. this compound and its n-methyl derivative are more active than codeine in the mouse hot-plate antinociceptive assay and will not suppor morphine dependence in rhesus monkeys. | 1978 | 413922 |
| induction of monooxygenases in rhesus monkeys by 3-methylcholanthrene: metabolism and mutagenic activation of n-2-acetylaminofluorene and benzo(a)pyrene. | induction of content and activity of hepatic and lung cytochrome p450-dependent monooxygenases by 3-methylcholanthrene (mca) was studied in male rhesus monkeys. hepatic microsomes were concomitantly studied for mutagenic activation of n-2-acetylaminofluorene (aaf) as well as with the use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. hepatic n-hydroxylation of aaf was increased sixfold to sevenfold after mca treatment; aryl hydrocarbon hydroxylase was similarly increased in both l ... | 1978 | 413928 |
| incorporation of (3h) lysine into the brain and spinal cord of the cebus (cebus appella) and rhesus (macacca mulata) monkeys. | the relative amounts of incorporation of [3h] lysine into various brain areas and segments of the spinal cord in adult cebus and rhesus monkeys were studied. one hour after subcutaneous injection of [3h] lysine, animals were sacrificed and the brain and spinal cord samples taken and processed for [3h] lysine incorporation into protein (lowry et al., 1951; wells and bernstein, 1976). analysis revealed marked differences in metabolism among brain areas within each species of monkey as well as acro ... | 1977 | 413933 |
| thoracic duct cannulation of the rhesus monkey (macaca mulatta) for lymphocyte collection: thoracic approach. | the thoracic duct of the rhesus monkey (macaca mulatta) was cannulated with medical grade tubing through a thoracatomy at right interspace 9-10. in 42 monkeys successfully cannulated, a mean of 1.194 x 10(9) lymphocytes was collected in the 70-hour period after surgery. a second collection, 1-3 weeks later, was possible for a shorter period (up to 60 hours) in a portion of these monkeys (15) with a smaller mean yield of lymphocytes (1.076 x 10(9). a third, but still shorter, collection period of ... | 1977 | 414020 |
| lumbar puncture for obtaining cerebrospinal fluid in the rhesus monkey (macaca mulatta). | | 1977 | 414022 |
| identification of hemoglobins within individual rhesus monkey (macaca mulatta) erythrocytes. | rabbit and goat antibodies to monkey adult and fetal hemoglobin were prepared and purified to apparent monospecificity. after conjugation with fluorescein isothiocyanate, the antibodies were employed to identify the hemoglobin types within individual cells in peripheral erythrocyte smears. the percentage of neonatal monkey erythrocytes containing fetal hemoglobin was found to decrease with time. the existence of adult or fetal hemoglobin in the erythrocytes appeared to be mutually exclusive. | 1977 | 414023 |
| measurement of hemolytic complement and the third component of complement in nonhuman primates. | complement, determined by hemolytic assay, and the third component of complement (c3), determined by radial immunodiffusion assay, were measured in nine nonhuman primate species. the species studied were the titi (callicebus mollach). the sooty mangabey (cercocebus atys), the thick-tailed galago or bushbaby (galago crassicaudatus panganiensis), the crab-eating monkey (macaca fascicularis), the rhesus monkey (macaca mulatta), the bonnet monkey (macaca radiata), the stumptailed macaque (macaca spe ... | 1977 | 414024 |
| conspecific images as elements of compound stimuli controlling operant responding in female rhesus monkeys. | six adult female rhesus monkeys (macaca mulatta) performed food-reinforced button presses in a compound stimulus discrimination paradigm. three subjects were trained on a compound stimulus consisting of a color motion picture of an adult male rhesus superimposed over a homogeneous blue field of color. a second group of three subjects was trained on a compound consisting of a color slide depicting an adult male rhesus and the blue field. subsequent testing of relative stimulus control exerted by ... | 1977 | 414197 |
| the effects of hypotension and hypovolaemia on the liberation of vasopressin during haemorrhage in the unanaesthetized monkey (macaca mulatta). | using unanaesthetized monkeys, experiments were performed to examine the effects of haemorrhage on the liberation of arginine vasopressin (avp). haemorrhages of 10%, 15% or 20% total blood volume were performed via a catheter with its tip in the abdominal vena cava. a catheter in the left internal jugular vein was used for blood sampling. arterial blood pressure was monitored via a catheter whose tip resected in an iliac artery. the monkeys showed no signs of discomfort from this catheterisation ... | 1977 | 414200 |
| regulation of appetite during total parenteral nutrition. | to study effects of total parenteral nutrition (tpn) on appetite, in an effort to obtain an objective assessment of hunger separated from underlying pathology, caloric intake and levels of tpn were measured in two male rhesus monkeys. tpn was found to affect appetite by reducing voluntary food intake. one monkey showed precise regulation of daily oral caloric intake and maintained stable body weight during this period. the other monkey did not show such precise regulation. when tpn was stopped, ... | 1978 | 414211 |
| effects of clomipramine and other inhibitors of monoamine uptake on the sexual behaviour of female rats and rhesus monkeys. | | 1977 | 414218 |
| cholesterol and hormone levels in sera of juvenile female rhesus monkeys. | | 1978 | 414237 |
| changes in testosterone and behavior during adolescence in the male rhesus monkey. | five adolescent male rhesus were followed for 3 years, from age 2 through age 4, with the collection of monthly testosterone levels, along with observation of behavior. testosterone levels showed initial rises by age 3, but did not show the adult male seasonal pattern until 4. play behavior fell significantly from age 2 to age 3, while sex behavior showed seasonal increases in both year 2 and year prior to the rise in plasma testosterone. the number of adult males in the social group may influen ... | 1978 | 414289 |
| development and evaluation of a new water-soluble iodinated myelographic contrast medium with markedly reduced convulsive effects. | a new water-soluble myelographic contrast agent with more hydrophilic properties than metrizamide was developed and tested in the primate (macaca mulatta) and the cat. a new animal model that allows study of the convulsive effects of intrathecally administered contrast agents in the awake monkey was designed. with this sensitive model the new contrast agent was shown to have a remarkable reduced convulsive effect when compared with metrizamide and other media. intrathecal hypertonic solutions in ... | 1978 | 414304 |
| the hypothalamic regulation of lh and fsh secretion in the rhesus monkey. | | 1978 | 414314 |
| measurement of regional substrate utilization rates by emission tomography. | emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. the concept was validated by measuring brain glucose utilization with carbon--11-labeled glucose in rhesus monkeys. | 1978 | 414358 |
| [antibodies in rhesus-monkeys after experimental infection with african lung-worms (paragonimus uterobilateralis and p. africanus) (author's transl)]. | the following publication gives a report about serological studies on experimentally infected macaca mulatta with paragonimus uterobilateralis and p. africanus supplied by parasitological findings and chest x-ray experiments from other authors. it was shown that at first in the chronological sequence serological changes were noticed in the animals followed by x-ray changes of the lungs. somewhat later the monkeys started with the excretion of worm-eggs. egg production did not take place in all m ... | 1977 | 414393 |
| the metabolism of ftorafur in the beagle dog and rhesus monkey. | 1. ftorafur, a fluorinated pyrimidine nucleoside antimetabolite, is metabolized by the beagle dog and rhesus monkey to 5-fluorouracil, which is subsequently biotransformed to the corresponding nucleosides, to alpha-fluoro-beta-ureidopropionic acid, to urea and to co2. 2. in the dog, urea was the primary urinary metabolite while in the monkey, alpha-fluoro-beta-ureidopropionic acid predominated. 3. the dog and monkey excrete about 35 percent of the recovered dose as co2. 4. the possibility that f ... | 1977 | 414463 |
| evaluation of central nervous adaptability to low stress and high stress categories in rhesus monkeys by multivariate evoked potential analyses [proceedings]. | | 1977 | 414507 |
| histological analysis of the growth of the mandibular condyle in the rhesus monkey (macaca mulatta). | | 1978 | 414614 |
| effects of androgen administration on sexual invitations by female rhesus monkeys (macaca mulatta). | pairs of adult rhesus monkeys of opposite sexes (12 pairs) were studied during 1-h mating tests (986 tests). ovariectomized females received 5 microgram oestradiol intravaginally throughout to keep them attractive to males and maintain a relatively constant level of male sexual activity. females were given subcutaneous silastic implants of testosterone to change their sexual receptivity. a threefold change in sexual invitations resulted from the implantation and removal of testosterone in the ab ... | 1977 | 414641 |
| effects of immunisation on dental caries in the first permanent molars in rhesus monkeys. | | 1977 | 414700 |
| empirical model of intracranial pressure and head motion resulting from a vibrating seated rhesus. | a series of experiments was designed to measure the head x and z accelerations and the intracranial pressure in the unrestrained head of a rhesus monkey. the subject was exposed to a continuum of vibration frequencies from 2 to 35 hz and peak acceleration amplitudes of 5, 10, 20, and 40 m/s2. the resulting data was used to build a frequency response model relating the head accelerations and pressures to the torso acceleration. the head-to-torso relationships, based upon a single subject, were bo ... | 1978 | 414728 |
| conjugated and unconjugated bilirubins in bile of humans and rhesus monkeys. structure of adult human and rhesus-monkey bilirubins compared with dog bilirubins. | 1. bilirubin-ixalpha, -ixalpha diglucuronide, -ixalpha monoglucuronide, -ixalpha monoglucoside -ixalpha monoxyloside, a bilirubin-ixalpha diconjugate containing glucose and another unknown compound, and bilirubin-ixbeta are present in gall-bladder bile of adult human, rhesus monkey and dog. dog bile normally also contains other bilirubin-ixalpha diconjugates, i.e. compounds containing two conjugating sugars such as glucuronic acid and glucose, glucuronic acid and xylose and glucose xylose. 2. az ... | 1977 | 414741 |
| patch-like termination of thalamic fibers in the putamen of the rhesus monkey: an autoradiographic study. | | 1978 | 414821 |
| heterosexual, autosexual and social behavior of adult male rhesus monkeys with medial preoptic-anterior hypothalamic lesions. | bilateral radiofrequency lesions were made in the medial preoptic-anterior hypothalamic (mp-ah) area of 6 adult male rhesus monkeys; 5 sham-lesioned subjects served as controls. behavioral analysis consisted of observations on copulatory behavior, yawning, masturbation and some aspects of social behavior. mp-ah lesions reduced or completely eliminated the display of manual contacts of the partner, mounts, intromissions and ejaculations without interfering with masturbation. yawning, a sexually d ... | 1978 | 414825 |
| comparison of the convulsant effects of cocaine and pseudococaine in the rhesus monkey. | the convulsant effects of cocaine and its c2-epimer, pseudococaine on eeg, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain. intravenous injections of cocaine (3.0 to 8.0 mg/kg) and pseudococaine (3.0 to 7.0 mg/kg) in the animals produced a similar pattern of clonic convulsions accompanied by marked increases in the heart and respiratory rates with mydriasis and excessive salivation. however, both isomers showed different effects on t ... | 1977 | 414826 |
| harmonic analysis of the left ventricular pressure waveform of the primate. | most attempts to quantitate myocardial function rely on morphologic features of complex pressure waveforms to reflect the functional properties of the ventricular myocardium. relationships between waveform components and the function of the organ generating them were examined in 38 rhesus monkeys by harmonic analysis of left ventricular pressure waveforms. in the basal state, harmonic content was closely correlated (r=0.98) with hemodynamic state, as quantitated by heart rate, systolic and diast ... | 1978 | 414837 |
| induction of hapten-specific cell-mediated immunity in rhesus monkeys treated with adsorbent purified antilymphocyte antibody. | rhesus monkeys were treated with sufficient amounts of rabbit antilymphocyte sera and immunoadsorbent purified antilymphocyte antibody to retain full-thickness skin grafts 23 and 29 days respectively. during this immunosuppressed period hapten-specific cell-mediated immunity was induced in six of seven rhesus monkeys immunized with p-azophenylarsono-n-acetyltyrosine (r-tyr) in complete freund's adjuvant. these observations suggest that in rhesus monkeys different populations of t cells may be re ... | 1977 | 414990 |
| antibody mediated mechanisms of immunity to malaria induced by vaccination with plasmodium knowlesi merozoites. | rhesus monkeys vaccinated with merozoites in fca are protected against challenge with several strains and variants of plasmodium knowlesi. vaccination induces sterilizing immunity which is species specific. merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. however, vaccination using adjuvants other than fca may induce inhibitory antibody without ... | 1978 | 414993 |
| regional differences in the metabolism of testosterone in vitro in the epididymis & ductus deferens of the adult rhesus monkey macaca mulatta. | regional differences in the metabolism of testosterone in vitro in the epididymis (1.5 cm segments) and ductus deferens (2 cm segments) were investigated in the adult rhesus monkey, macaca mulatta. the conversion of tritiated testosterone to its 5alpha-reduced derivatives increased from the proximal to the distal regions of the epididymis. the total amount of 5alpha-reduced products in the subsequent segments of the epididymis was highest in the intact monkey and on the intact side of the unil ... | 1977 | 414995 |
| histochemical localization of dehydrogenases in different regions of the epididymis of the adult rhesus monkey macaca mulatta. | | 1977 | 414996 |
| histochemical distribution of metabolites & lipolytic enzymes in different regions of the epididymis of the adult rhesus monkey macaca mulatta. | | 1977 | 414997 |
| mammalian cones: disc shedding, phagocytosis, and renewal. | during the past several years we have examined a variety of different mammalian retinas for ultrastructural evidence of cone disc shedding and rpe phagocytosis. in this paper we review our previously published evidence from squirrel and human retinas as well as present new evidence of cone disc shedding in rhesus monkey and cat. all these species show definitive evidence for the shedding of discs from cone outer segments and the phagocytosis of shed discs by apical processes of the rpe; both of ... | 1978 | 415019 |
| accuracy of aqueous humor flow determination by fluorophotometry. | after corneal iontophoresis of fluorescein, freshly enucleated rhesus monkey eyes were perfused at a known rate with glutathione-bicarbonate-ringer's solution. total fluorescein mass and aqueous fluorescein concentration were measured with a fluorophotometer every 15 min for 6 to 8 hr. the aqueous flow was calculated from the fluorophotometry data by the second method of jones and maurice. this flow was then compared to the known perfusion rate. the curve for total fluorescence decay was not pre ... | 1978 | 415021 |
| the thalamic afferents to the inferior parietal lobule of the rhesus monkey. | | 1978 | 415071 |
| the effects of severe keratitis on corneal transmission. | an investigation into the effects of keratitis on corneal light transmission is presented. transmission data from 9 diseased corneas are compared to those of 22 normal corneas in the 0.3-0.8 micron spectral range. rhesus monkey corneas were used in the study. several color photographs illustrate varieties of idiopathic keratitis in rhesus monkeys. | 1978 | 415084 |
| diurnal variation in plasma testosterone and cortisol in rhesus monkeys living in social groups. | concentrations of cortisol and testosterone in the plasma of adult male rhesus monkeys living in social groups were determined during a 27-h period. capture and venipuncture of experienced, conditioned animals did not lead to a fall in the concentration of testosterone in the plasma during the 90 min immediately after removal from the group. both plasm cortisol and plasma testosterone concentrations showed a significant fall and rise in samples collected every 3 h during a 27-h period, even thou ... | 1978 | 415103 |
| tubulin and microtubule-like structures in mammalian acrosomes. | immunofluorescence and electron microscopy were used to demonstrate the presence of tubulin and microtubule-like structures in rabbit and rhesus monkey sperm acrosomes. the distribution of tubulin within the acrosome appeared similar to the distribution of proteolytic activity, suggesting an association of proteinase with these structures. electron microscopy of rhesus monkey sperm incubated in vitro demonstrated a progressive condensation of the acrosomal matrix into microtubule-like structure. ... | 1978 | 415112 |