| possible involvement of mycoplasma hominis in inhibiting the formation of biofilms by uropathogenic escherichia coli (upec). | here we examined the involvement of mycoplasma hominis in the formation of biofilms by uropathogenic escherichia coli (upec) strain cft073. initially, we thought that m. hominis does not affect the fitness of upec, including the growth and production of signaling molecules, such as autoinducer-2 and indole. we found, however, that the presence of m. hominis significantly decreased the degree of biofilm formation by upec cft073 (approximately a 60% reduction for 10(5) ccu/ml of m. hominis as comp ... | 2013 | 24096662 |
| improved method for expression and isolation of the mycoplasma hominis arginine deiminase from the recombinant strain of escherichia coli. | arginine deiminase is a promising anticancer drug active against melanoma, hepatocarcinoma and other tumors. recombinant strains of escherichia coli that express arginine deiminase from pathogenic bacteria mycoplasma have been developed. however, production costs of heterologous arginine deiminase are high due to use of an expensive inducer and extraction buffer, as well as using diluted culture for enzyme induction. we report on a new advanced protocol for mycoplasma hominis arginine deiminase ... | 2013 | 23928331 |
| mycoplasma agalactiae mag_5040 is a mg2+-dependent, sugar-nonspecific snase recognised by the host humoral response during natural infection. | in this study the enzymatic activity of mycoplasma agalactiae mag_5040, a magnesium-dependent nuclease homologue to the staphylococcal snase was characterized and its antigenicity during natural infections was established. a uga corrected version of mag_5040, lacking the region encoding the signal peptide, was expressed in escherichia coli as a gst fusion protein. recombinant gst-mag_5040 exhibits nuclease activity similar to typical sugar-nonspecific endo- and exonucleases, with dna as the pref ... | 2013 | 23469065 |
| pregnancy-induced changes in immune protection of the genital tract: defining normal. | both the state of pregnancy as well as disruption of vaginal flora and immune mediators may increase the risk of human immunodeficiency virus-1 acquisition. the objective of this study was to define immune changes in lower genital and systemic immunity associated with normal pregnancy. | 2013 | 23313311 |
| fetal membrane biomarker network diversity and disease functions induced by intra-amniotic pathogens. | intra-amniotic pathogens and by-products activate innate immune responses encompassing multitudes of signaling molecules and pathways that can result in spontaneous preterm birth (ptb). this study investigates fetal membrane response to bacterial stimulation using a bioinformatics approach. | 2013 | 23216633 |
| amniotic fluid and maternal race influence responsiveness of fetal membranes to bacteria. | spontaneous preterm birth (ptb) and preterm prelabor rupture of membranes (pprom) occur more frequently in african-american women than in other racial groups. this may be due to an enhanced inflammatory response to pathogens associated with the condition. it is also possible that amniotic fluid (af) has different immunomodulatory properties in african-american women that increase their risk of ptb and pprom. to test this, we cultured fetal membranes from european-american and african-american wo ... | 2012 | 23021257 |
| bacterial modulation of human fetal membrane toll-like receptor expression. | preterm premature rupture of fetal membranes (pprom) occurs in 30-40% of spontaneous preterm births (ptb) and is associated with intra-amniotic infection and inflammation. the membranes may sense and respond to microbes via toll-like receptors (tlrs); however, little is known about their expression and regulation in this tissue. the objective of this study was to evaluate the expression of tlrs 1-10 in fetal membranes after exposure to pathogens associated with intra-amniotic infection and ptb. | 2013 | 22967004 |
| combinations and loads of bacteria affect the cytokine production by fetal membranes: an in vitro study. | the polybacterial invasion and inflammation of the amniotic cavity is a common scenario in ptb, and then, we analyzed the cytokine production by human fetal membranes to better understand the host response to polybacterial infections. | 2016 | 27870156 |
| anti-inflammatory elafin in human fetal membranes. | elafin is a low molecular weight protein with antileukoproteinase, anti-inflammatory, antibacterial and immunomodulating properties. the profile of elafin in fetal membranes is not well characterized. this study determined the changes in elafin expression and concentration in human fetal membrane from patients with preterm prelabor rupture of membranes (pprom) and in vitro in response to intra-amniotic polymicrobial pathogens. | 2017 | 27580179 |
| mycoplasma hominis and gardnerella vaginalis display a significant synergistic relationship in bacterial vaginosis. | gardnerella vaginalis plays an important role in bacterial vaginosis (bv,) while the role of genital mollicutes is less obvious. the diagnosis of bv by use of the current gram stain nugent score is also suboptimal for defining the role of mollicutes that lack a cell wall. since bacterial load and diversity is an important prerequisite for bv, real-time quantitative polymerase chain reaction (qpcr) assays enable these to be assessed. the purpose of this study was to define the role of genital mol ... | 2016 | 26796553 |
| the common vaginal commensal bacterium ureaplasma parvum is associated with chorioamnionitis in extreme preterm labor. | to assess the association of vaginal commensal and low-grade pathogenic bacteria including ureaplasma parvum, ureaplasma urealyticum, mycoplasma hominis, mycoplasma genitalium, group b streptococcus (gbs), and gardnerella vaginalis, in women who delivered preterm at less than 37-week gestation in the presence or absence of inflammation of the chorioamnionitic membranes. | 2016 | 26795404 |
| severe pelvic abscess formation following caesarean section. | we report a case of a 24-year-old woman with severe pelvic abscess formation 2 weeks after secondary caesarean section. the isolated pathogens were a mixture of gardnerella vaginalis, mycoplasma hominis and ureaplasma urealyticum. after initial resistance to systemic antibiotic treatment, she underwent radiologically-guided drainage of the abscesses, whereon she had a continuous recovery. | 2015 | 25911355 |
| ethnic variations in cervical cytokine concentrations and vaginal flora during pregnancy. | pregnancy-mediated changes in immunity may influence risk of hiv-1 acquisition. this risk appears greatest among non-caucasian women. | 2015 | 25041358 |
| microbial and vaginal determinants influencing mycoplasma hominis and ureaplasma urealyticum genital colonization in a population of female patients. | mycoplasma hominis and ureaplasma urealyticum are associated with chorioamnionitis, preterm delivery and pelvic inflammatory disease. the aim of this study was to evaluate the possible risk factors of co-colonization by m. hominis in patients already colonized by u. urealyticum and compare demographic parameters, vaginal ph and microbiota of women colonized by u. urealyticum or m. hominis. a total of 452 patients positive for u. urealyticum or m. hominis were analysed, 421 (93.1%) of whom were p ... | 2013 | 24008852 |
| a case of mycoplasma hominis disseminated infection in a human immunodeficiency virus-1-infected pregnant woman with hypogammaglobulinemia. | | 2017 | 25648665 |
| vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis. | in this study, we sought to find novel bacterial and metabolic hallmarks for bacterial vaginosis (bv). we studied the vaginal microbiome and metabolome of vaginal fluids from bv-affected patients (n = 43) and healthy controls (n = 37) by means of an integrated approach based on quantitative polymerase chain reaction (qpcr) and proton nuclear magnetic resonance ((1)h-nmr). the correlations between the clinical condition and vaginal bacterial communities were investigated by principal component an ... | 2015 | 26385347 |
| epidemiology and outcomes of deep surgical site infections following lung transplantation. | we conducted a retrospective study of deep surgical site infections (ssis) among consecutive patients who underwent lung transplantation (ltx) at a single center from 2006 through 2010. thirty-one patients (5%) developed ssis at median 25 days after ltx. empyema was most common (42%), followed by surgical wound infections (29%), mediastinitis (16%), sternal osteomyelitis (6%), and pericarditis (6%). pathogens included gram-positive bacteria (41%), gram-negative bacteria (41%), fungi (10%) and my ... | 2013 | 23710593 |
| [effect of low temperature plasma on various mycoplasma species]. | study the influence of low temperature (cold) electrolyte plasma (cep) on survivability of some mycoplasma strains growing in agar as well as mycoplasma that most frequently contaminate transplantable human cell lines of normal and malignant origin with the aim of decontamination. | 2013 | 23805670 |
| simultaneous detection of mycoplasma pneumoniae, mycoplasma hominis and mycoplasma arthritidis in synovial fluid of patients with rheumatoid arthritis by multiplex pcr. | it has been recognized that infectious agents, such as different bacteria and viruses, may play a role in the developing of rheumatoid arthritis (ra). recently, the mycoplasma species has been implicated in the pathogenesis of ra. | 2015 | 26058928 |
| analysis of the complete mycoplasma hominis lbd-4 genome sequence reveals strain-variable prophage insertion and distinctive repeat-containing surface protein arrangements. | the complete genome sequence of mycoplasma hominis lbd-4 has been determined and the gene content ascribed. the 715,165-bp chromosome contains 620 genes, including 14 carried by a strain-variable prophage genome related to mycoplasma fermentans mfv-1 and mycoplasma arthritidis mav-1. comparative analysis with the genome of m. hominis pg21(t) reveals distinctive arrangements of repeat-containing surface proteins. | 2015 | 25720686 |
| [antimycoplasmic activity of fermentation broth of trichoderma harzianum rifai f-180, an organism producing l-lysine-α-oxidase, an antitumor and antiviral enzyme]. | a concentrate of the fermentation broth of trichoderma harzianum rifai f-180, an organism producing l-lysine-α-oxidase, an antitumor and antiviral enzyme, with the activity in the fermentation broth of 0.54-0.56 u/mi was recovered. the effect of the concentrate on the mycoplasmas growth was investigated for the first time. two representatives of mycoplasmafaceae, i.e. mycoplasma hominis and mycoplasma fermentans and one representative of aholeplasmataceae. i. e. aholeplasma laidlawii were used. ... | 2014 | 26448986 |
| the prevalence of six species of mycoplasmataceae in an hiv/aids population in jiangsu province, china. | this study employed culture and polymerase chain reaction (pcr) to examine the prevalence of ureaplasma urealyticum, mycoplasma hominis, mycoplasma genitalium, mycoplasma fermentans, mycoplasma penetrans and mycoplasma pirum in 210 hiv/aids patients, 455 sexually transmitted infection (sti) clinic attendees and 245 healthy volunteers from first-void urine specimens for men and endocervical swabs for women. u. urealyticum and m. hominis were detected in 107 (51.0%) and 69 (32.9%) patients in the ... | 2012 | 22930310 |
| in vitro antimycoplasmal activity of citrus bergamia essential oil and its major components. | forty-two strains of mycoplasma hominis (including pg21), 2 strain of mycoplasma fermentans (pg18 and k7), 1 strain of mycoplasma pneumoniae (strain m129) were investigated for their susceptibilities to citrus bergamia essential oil and to its major components (limonene, linalyl acetate and linalool). c. bergamia essential oil inhibited mycoplasmas at concentrations from 0.5 to 1% (mic value as % v/v). m. hominis showed mic(50) values of 0.5% and mic(90) values of 1%; m. pneumoniae showed a mic ... | 2012 | 22465092 |
| microbial invasion of the amniotic cavity in midtrimester pregnancies using molecular microbiology. | the objective of the study was to determine the frequency of microbial invasion of the amniotic cavity in the midtrimester of pregnancy in patients undergoing amniocentesis for clinical indications. | 2017 | 28268197 |
| mollicutes in vaginal microbiology: mycoplasma hominis, ureaplasma urealyticum, ureaplasma parvum and mycoplasma genitalium. | mycoplasma hominis was isolated in 1937 from the human genital tract, followed 17 years later by ureaplasma urealyticum and 27 years after that by mycoplasma genitalium. the first two proved relatively easy to culture but the latter required a polymerase chain reaction assay for further studies. in sexually mature women, m. hominis may be found in the vagina/cervix of about 20-50%, ureaplasmas in 40-80% and m. genitalium in 0-5%. some heterogeneity has been found among strains of all these speci ... | 2017 | 28263902 |
| mycoplasma/ureaplasma infection in pregnancy: to screen or not to screen. | mycoplasmata have been linked to pregnancy complications and neonatal risk. while formerly a limited number of species could be discovered by cultures, molecular biology nowadays discovers both lower quantities and more diverse species, making us realize that mycoplasmata are ubiquitous in the vaginal milieu and do not always pose a danger for pregnant women. as the meaning of mycoplasmata in pregnancy is not clear to many clinicians, we summarized the current knowledge about the meaning of diff ... | 2017 | 28099135 |
| prevalence and antibiotic susceptibility of mycoplasma hominis and ureaplasma urealyticum in genital samples collected over 6 years at a serbian university hospital. | mycoplasma hominis and ureaplasma urealyticum are implicated in a wide array of infectious diseases in adults and children. since some species have innate or acquired resistance to certain types of antibiotics, antibiotic susceptibility testing of mycoplasma isolated from the urogenital tract assumes increasing importance. | 2016 | 26728808 |
| mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis. | the relationship between mycoplasma and ureaplasma infection and male infertility has been studied widely; however, results remain controversial. this meta-analysis investigated the association between genital ureaplasmas (ureaplasma urealyticum, ureaplasma parvum) and mycoplasmas (mycoplasma hominis, mycoplasma genitalium), and risk of male infertility. differences in prevalence of ureaplasma and mycoplasma infection between china and the rest of the world were also compared. study data were co ... | 2015 | 26311339 |
| detection of genital mycoplasmal infections among infertile females by multiplex pcr. | women reproductive system is a suitable environment for growth of various pathogen and nonpathogenic microorganisms. mycoplasmataceae is a family of bacteria which cause oligosymptomatic genital infections. the complications caused by these bacteria may lead to infertility in women. the aim of this study was detection of genital mycoplasma hominis, ureaplasmaurealyticum and mycoplasma genitalium among infertile females who referred to the infertility clinics. | 2014 | 25926957 |
| development and clinical application of an invaderplus® assay for the detection of genital mycoplasmas. | we developed a pcr-based assay involving invader® technology for detection of the genital mycoplasmas of mycoplasma genitalium, mycoplasma hominis, ureaplasma urealyticum, and ureaplasma parvum. we compared its performance with that of a pcr-microtiter plate hybridization assay, which we developed previously, in detecting genital mycoplasmas in first-voided urine (fvu) specimens from men with non-gonococcal urethritis. the tests targeting each of the genital mycoplasmas were specific for the res ... | 2015 | 25892209 |
| isolation and molecular identification of mycoplasma genitalium from the secretion of genital tract in infertile male and female. | mycoplasmas can cause acute and chronic diseases at multiple sites with wide-range complications and have been implicated as cofactors in diseases. the infections influenced form genital mycoplasmas specifically mycoplasma hominis and mycoplasma genitalium potentially affect reproductive disorders, and infertility. | 2014 | 25469132 |
| trichomonas vaginalis infection in symbiosis with trichomonasvirus and mycoplasma. | trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. this review focuses on symbiotic trichomonasvirus and mycoplasma carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. improved diagnostics and larger clinical inte ... | 2017 | 28366838 |
| pelvic abscess due to mycoplasma hominis following caesarean section. | mycoplasma hominis is associated with genito-urinary tract infection and adverse pregnancy outcomes. however, whether the species is a true pathogen or part of the genito-urinary tracts natural flora remains unclear. | 2016 | 28348780 |
| mycoplasma hominis periaortic abscess following heart-lung transplantation. | we report the first case of mycoplasma hominis periaortic abscess after heart-lung transplantation, to our knowledge. the absence of sternal wound infection delayed the diagnosis, but the patient successfully recovered with debridement surgeries and long-term antibiotic therapy. owing to the difficulty in detection and the intrinsic resistance to beta-lactams, m. hominis infections are prone to being misdiagnosed and undertreated. m. hominis should be suspected in cases where conventional microb ... | 2017 | 28294481 |
| case report of a 6-year-old girl with mycoplasma hominis ventriculoperitoneal shunt infection. | mycoplasma hominis is a rare causative pathogen for surgical site infections after neurosurgical procedures. this organism lacks a cell wall, rendering it undetectable by gram staining and making it resistant to beta-lactam antibiotics. in addition, some special techniques are required to identify this organism. thus, it is very difficult to diagnose infections caused by this pathogen. here, the authors report a pediatric case of m. hominis ventriculoperitoneal shunt (vps) infection with central ... | 2017 | 28291426 |
| comparison of mycoplasma ies, mycofast revolution and mycoplasma ist2 to detect genital mycoplasmas in clinical samples. | culture is regarded as the gold standard for the detection of genital mycoplasma in clinical samples. commercially available diagnostic kits, based on liquid broth cultures, provide interesting alternatives to conventional culture. we assessed the laboratory performances of mycoplasma ies (ies), the mycofast revolution (rev) and mycoplasma ist 2 (ist2) compared to a7 agar plates for the detection of ureaplasma urealyticum and mycoplasma hominis in clinical samples. | 2017 | 28141596 |
| cloning, stability, and modification of mycoplasma hominis genome in yeast. | mycoplasma hominis is a minimal human pathogen that is responsible for genital and neonatal infections. despite many attempts, there is no efficient genetic tool to manipulate this bacterium, limiting most investigations of its pathogenicity and its uncommon energy metabolism that relies on arginine. the recent cloning and subsequent engineering of other mycoplasma genomes in yeast opens new possibilities for studies of the genomes of genetically intractable organisms. here, we report the succes ... | 2017 | 28118540 |
| association between preterm labor and genitourinary tract infections caused by trichomonas vaginalis, mycoplasma hominis, gram-negative bacilli, and coryneforms. | preterm labor (ptl) is responsible for most cases of neonatal death. in most of these cases, the causes of ptl have not been established although several risk factors have been described. therefore, the aim of this study was to investigate risk factors for ptl before 37 gestational weeks among egyptian women. | 2017 | 28094234 |
| prevalence of mycoplasma hominis and ureaplasma urealyticum in women undergoing an initial infertility evaluation. | mycoplasma hominis and ureaplasma urealyticum are potentially pathogenic bacterial species that are frequently isolated from the urogenital tract of women. these pathogens could be responsible for various genitourinary diseases and have been associated with adverse pregnancy outcomes and female fertility problems. the aim of this study was to analyse the presence of m. hominis and u. urealyticum in the cervical canal of uterus of women with and without fertility problems. | 2016 | 28078900 |
| postoperative mycoplasma hominis brain abscess: keep it in mind! | a temporal lobe abscess was diagnosed in a 57-year-old man. a urethral catheter had been inserted 12 days earlier, just prior to clot evacuation of a subacute haematoma secondary to an arterio-venous malformation. fever persisted despite debridement and treatment with meropenem and vancomycin. gram stains of operative samples showed no bacteria. extended cultures grew pinpoint colonies after 5 days. meanwhile, sequencing of bacterial 16s rdna from operative specimens had identified mycoplasma ho ... | 2017 | 28069785 |
| mycoplasma hominis induces mediastinitis after a tonsillar abscess. | mycoplasma hominis is commonly involved in genitourinary tract infections. we report a 59-year-old man who developed a m. hominis-associated mediastinitis following acute tonsillar infection. | 2016 | 27957362 |
| genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of mycoplasma hominis. | mycoplasma hominis is an opportunistic human pathogen, associated with clinically diverse disease. currently, there is no standardised method for typing m. hominis, which would aid in understanding pathogen epidemiology and transmission. due to availability and costs of whole genome sequencing and the challenges in obtaining adequate m. hominis dna, the use of whole genome sequence analysis to provide clinical guidance is unpractical for this bacterial species as well as other fastidious organis ... | 2016 | 27881098 |
| asymptomatic infection with mycoplasma hominis negatively affects semen parameters and leads to male infertility as confirmed by improved semen parameters after antibiotic treatment. | to elucidate the association between asymptomatic infections caused by mycoplasma hominis and male infertility and to evaluate the role of antibiotic therapy in the treatment of this failure. | 2017 | 27871827 |
| antibiotic resistance among ureaplasma spp. isolates: cause for concern? | there is growing global concern regarding the rise of antibiotic-resistant organisms. many of these reports have focused on various gram-positive and gram-negative pathogens, with little attention to the genus ureaplasma. ureaplasma spp. are associated with numerous infectious diseases affecting pregnant women, neonates and the immunocompromised. treatment options are extremely limited due to high levels of intrinsic resistance resulting from the unique physiology of these organisms and further ... | 2017 | 27798207 |
| neonate with mycoplasma hominis meningoencephalitis given moxifloxacin. | mycoplasma hominis is a commensal organism in the genitourinary tract that can cause life-threatening cns infections in neonates after intrauterine infection or through vertical transmission during birth. we present a case of an 11-day-old neonate presenting with fever and supporting laboratory evidence of a cns infection. no systemic maternal infection or maternal genitourinary tract infection occurred at the time of delivery. empirical treatment was initiated, consisting of amoxicillin, cefota ... | 2016 | 27641775 |
| mycoplasma hominis vertebral spine infection: case report and a review of infections of bone and joints. | mycoplasma hominis (m. hominis) is a common commensal that colonizes the human urogenital tract, wherein it is also known to cause genito-urinary infections. it has rarely been reported to cause spinal infections. | 2016 | 27234356 |
| meningitis in a chinese adult patient caused by mycoplasma hominis: a rare infection and literature review. | mycoplasma hominis, a well known cause of neonatal infection, has been reported as a pathogen in urogenital infections in adults; however, central nervous system (cns) infections are rare. we report here the first case of m. hominis meningitis in china, post neurosurgical treatment for an intracerebral haemorrhage in a 71-year-old male. | 2016 | 27729031 |
| in vitro activities of omadacycline (ptk 0796) and other antimicrobial agents against human mycoplasmas and ureaplasmas. | in vitro activities of omadacycline, a new aminomethylcycline, were determined for mycoplasma and ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. all omadacycline mics were <2 μg/ml. mic90s were 0.063 μg/ml for mycoplasma hominis, 0.25 μg/ml for mycoplasma pneumoniae, and 2 μg/ml for ureaplasma spp. omadacycline had the lowest mic90 among all drugs tested against m. hominis omadacycline activity was not affected by macrolide, tet ... | 2016 | 27671057 |
| comparative analysis of male and female populations on prevalence and antibiotic resistance of mycoplasma hominis in china, 2005-2014. | the aim of this study was to estimate the prevalence and antimicrobial resistance rate of mycoplasma hominis among male and female populations. a total of 67921 individuals were examined. all samples were isolated from patients at an outpatient clinic from january 2005 to december 2014. species identification and antibiotic susceptibility testing were performed using mycoplasma ist2. in this study, 523 (0.8%) and 4625 (6.8%) cultures, respectively, were positive for single m. hominis identificat ... | 2016 | 27530842 |
| prevalence and antibiotic susceptibility of ureaplasma urealyticum and mycoplasma hominis in xi'an, china. | this study analyzed the prevalence and antibiotic susceptibility of urogenital ureaplasma urealyticum and mycoplasma hominis isolated in xi'an, china. a total of 2161 individuals from 2011 to 2015 were included, and antibiotic susceptibility tests were performed by using the mycoplasma ist kit. of the individuals studied, 1018 (47.11 %) were identified to be positive for urogenital mycoplasmas. the single u. urealyticum, single m. hominis, and dual u. urealyticum and m. hominis infections accoun ... | 2016 | 27530531 |
| leukocyte lysis and cytokine induction by the human sexually transmitted parasite trichomonas vaginalis. | trichomonas vaginalis (tv) is an extracellular protozoan parasite that causes the most common non-viral sexually transmitted infection: trichomoniasis. while acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased hiv susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. heightened inflammation resulting from tv infection could account for these complication ... | 2016 | 27529696 |
| epidemiology of ureaplasma urealyticum and mycoplasma hominis in the semen of male outpatients with reproductive disorders. | the aim of the present study was to investigate the association between mycoplasma infection and infertility in male outpatients among a chinese population. epidemiological data, including prevalence, age distribution and antibiotic resistance profile of patients with an ureaplasma urealyticum or mycoplasma hominis infection were collected between 2009 and 2012. among the 7,374 individuals analyzed, 3,225 patients (43.7%) were determined to be positive for infection with u. urealyticum, m. homin ... | 2016 | 27443698 |
| prevalence and antibiotic susceptibility of mycoplasma hominis and ureaplasma urealyticum in pregnant women. | mycoplasma hominis (m. hominis) and ureaplasma urealyticum (u. urealyticum) are important opportunistic pathogens that cause urogenital infections and complicate pregnancy. the aim of this study was to investigate the prevalence, effects on pregnancy outcomes, and antimicrobial susceptibilities of m. hominis and u. urealyticum. we tested vaginal swabs obtained from 1035 pregnant women for the presence of genital mycoplasmas between june 2009 and may 2014. the laboratory and clinical aspects of g ... | 2016 | 27401661 |
| symbiotic association with mycoplasma hominis can influence growth rate, atp production, cytolysis and inflammatory response of trichomonas vaginalis. | the symbiosis between the parasitic protist trichomonas vaginalis and the opportunistic bacterium mycoplasma hominis is the only one currently described involving two obligate human mucosal symbionts with pathogenic capabilities that can cause independent diseases in the same anatomical site: the lower urogenital tract. although several aspects of this intriguing microbial partnership have been investigated, many questions on the influence of this symbiosis on the parasite pathobiology still rem ... | 2016 | 27379081 |
| survey on association between mycoplasma hominis endocervical infection and spontaneous abortion using polymerase chain reaction. | mycoplasma infections are suggested as etiology of adverse pregnancy outcomes. | 2016 | 27294216 |
| fatal nosocomial meningitis caused by mycoplasma hominis in an adult patient: case report and review of the literature. | meningitis due to mycoplasma hominis in adults is rarely described, with only three cases having been reported to date. a case of fatal meningitis in a 39-year-old patient after a neurosurgical procedure for a subarachnoid haemorrhage is reported herein. identification and treatment were significantly delayed because of the rarity of the aetiology and difficulty identifying this organism with the routinely used conventional methods, such as gram staining and agar growth on standard agar plates. ... | 2016 | 27208637 |
| association between maternal genital mycoplasma colonization and histologic chorioamnionitis in preterm births. | genital mycoplasmas (gms) can be associated with chorioamnionitis and preterm birth, but are viewed as commensal organisms with low virulence. we sought to determine if cervical gm colonization is associated with histologic chorioamnionitis independent of infection with other bacteria. | 2016 | 27197925 |
| postoperative mycoplasma hominis infection after robot-assisted laparoscopic radical prostatectomy: a case report. | a 59-year-old man developed a high fever, elevated white blood cell count, elevated c-reactive protein level, and perineal pain 5 days after robot-assisted laparoscopic radical prostatectomy. treatment with cefmetazole was ineffective. a urine specimen was submitted for culture on postoperative day 7, and mycoplasma hominis (m. hominis) was detected 1 week later. cefmetazole was therefore switched to quinolone. the clinical symptoms and laboratory data immediately showed marked improvement. m. h ... | 2016 | 27117965 |
| mycoplasma hominis meningitis in a full-term neonate: rapid recovery without specific treatment. | | 2016 | 27113078 |
| prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology. | although the idea of bacteria causing different types of cancer has exploded about century ago, the potential mechanisms of carcinogenesis is still not well established. many reports showed the involvement of m. hominis in the development of prostate cancer, however, mechanistic approach for growth and development of prostate cancer has been poorly understood. in the current study, we predicted m. hominis proteins targeting in the mitochondria and cytoplasm of host cells and their implication in ... | 2016 | 27027344 |
| [usefulness of conventional polymerase chain reaction for the detection of mycoplasma hominis, ureaplasma spp. and trichomonas vaginalis in female outpatient's genital samples]. | trichomonas vaginalis, mycoplasma hominis and ureaplasma spp. are microorganisms responsible for genitourinary and pregnancy pathologies. nucleic acid amplification methods have shown several advantages, but have not been widely studied for the detection of these microorganisms. | 2016 | 26965874 |
| genetic passive immunization with adenoviral vector expressing chimeric nanobody-fc molecules as therapy for genital infection caused by mycoplasma hominis. | developing pathogen-specific recombinant antibody fragments (especially nanobodies) is a very promising strategy for the treatment of infectious disease. nanobodies have great potential for gene therapy application due to their single-gene nature. historically, mycoplasma hominis has not been considered pathogenic bacteria due to the lack of acute infection and partially due to multiple studies demonstrating high frequency of isolation of m. hominis samples from asymptomatic patients. however, r ... | 2016 | 26962869 |
| computational prediction of mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology. | cancer has long been assumed to be a genetic disease. however, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. the cause and mechanism of the growth and development of prostate cancer due to mycoplasma hominis remain unclear. prostate cancer cells are infected and colonized by enteroinvasive m. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. we investigated ... | 2016 | 26874727 |
| surface lipoproteome of mycoplasma hominis pg21 and differential expression after contact with human dendritic cells. | to assess the lipoproteins that are involved in the interaction between mycoplasma hominis and human dendritic cells. | 2016 | 26849083 |
| antimicrobial susceptibility patterns of ureaplasma urealyticum and mycoplasma hominis isolated from pregnant women. | mycoplasma hominis and ureaplasma urealyticum bring with them an increased risk of pregnancy complications, such as premature membrane rupture, vaginitis and preterm birth. | 2015 | 26756001 |
| prevalence of ureaplasma urealyticum and mycoplasma hominis in high vaginal swab samples of infertile females. | mycoplasma hominis and ureaplasma urealyticum are important causative agents of vaginitis, cervicitis, postpartum sepsis, reproductive infections and infertility in both males and females. | 2015 | 26756000 |
| correction for gagneux-brunon et al., mycoplasma hominis, a rare but true cause of infective endocarditis. | | 2016 | 26719585 |
| a disseminated mycoplasma hominis infection in a patient with an underlying defect in humoral immunity. | non-urogenital mycoplasma hominis infections are rare, but may cause life-threatening complications. we describe a case of disseminated m. hominis infection with extensive abscess formation in an immunocompromised patient with iatrogenic hypogammaglobulinemia under rituximab treatment. | 2016 | 26546371 |
| ureaplasma urealyticum and mycoplasma hominis infections and semen quality in 19,098 infertile men in china. | this study aimed to determine the incidence of ureaplasma urealyticum and mycoplasma hominis infections in infertile and fertile men and to investigate their effects on the semen quality. the study also aimed to analyze the drug susceptibility of uu and mh to provide guidance for reasonable antibiotic use. | 2016 | 26537883 |
| culture-negative endocarditis: mycoplasma hominis infection. | | 2015 | 26481285 |
| [persistence of mycoplasma during urolithiasis]. | study the frequency of detection of mycoplasma and ureaplasma in clinical material from urolithiasis patients. | 2015 | 26470428 |
| antibiotic susceptibility and sequence type distribution of ureaplasma species isolated from genital samples in switzerland. | antibiotic resistance in ureaplasma urealyticum/ureaplasma parvum and mycoplasma hominis is an issue of increasing importance. however, data regarding the susceptibility and, more importantly, the clonality of these organisms are limited. we analyzed 140 genital samples obtained in bern, switzerland, in 2014. identification and antimicrobial susceptibility tests were performed by using the mycoplasma ist 2 kit and sequencing of 16s rrna genes. mics for ciprofloxacin and azithromycin were obtaine ... | 2015 | 26195516 |
| an excision-competent and exogenous mosaic transposon harbors the tetm gene in multiple mycoplasma hominis lineages. | | 2015 | 26195506 |
| [microbial communities on kidney stones]. | the clinical material obtained surgically in patients with kidney stone disease (ksd) was tested for content of the stone microflora using pcr and standard microbiological methods. it was demonstrated that about 50% of stones in patients with ksd were infected with various infection agents as observed using standard microbiological and molecular genetic methods. the percentage of detection of the mycoplasma hominis using cultural method is lower than the percentage detected using pcr, which is d ... | 2015 | 26182663 |
| high rates of double-stranded rna viruses and mycoplasma hominis in trichomonas vaginalis clinical isolates in south brazil. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in world, with 276.4 million new cases each year. t. vaginalis can be naturally infected with mycoplasma hominis and trichomonasvirus species. this study aimed to evaluate the prevalence of t. vaginalis infected with four distinct t. vaginalis viruses (tvvs) and m. hominis among isolates from patients in porto alegre city, south brazil. an additional goal of this study w ... | 2015 | 26160539 |
| complete genome sequence of mycoplasma hominis strain sprott (atcc 33131), isolated from a patient with nongonococcal urethritis. | presented here is the complete and annotated genome sequence of mycoplasma hominis sprott (atcc 33131). the chromosome comprises 695,214 bp, which is approximately 30 kb larger than the syntenic genome of m. hominis pg21(t). tetracycline resistance of strain sprott is most probably conferred by the tetm determinant, harbored on a mosaic transposon-like structure. | 2015 | 26159538 |
| mycoplasma hominis, a rare but true cause of infective endocarditis. | mycoplasma spp. are rarely recognized agents of infective endocarditis. we report a case of mycoplasma hominis prosthetic valve endocarditis diagnosed by 16s ribosomal dna (rdna) pcr and culture of valves in a 74-year-old man. we reviewed the literature and found only 8 other cases reported. | 2015 | 26135868 |
| colonization of mycoplasma hominis and ureaplasma urealyticum in pregnant women and their transmission to offspring. | mycoplasma hominis and ureaplasma urealyticum are important opportunistic pathogens that cause urogenital infections and accelerated newborn delivery in pregnant women. moreover genital mycoplasmas have been implicated in different neonatal diseases such as pneumonia, sepsis and meningitis. this study was conducted to find out the prevalence and transmission rate of these two organisms in pregnant women and their neonates. | 2014 | 25802703 |
| epidemiology of mycoplasma acquisition in male hiv-1 infected patients: a multistage cross-sectional survey in jiangsu, china. | mycoplasma infections are most frequently associated with disease in the urogenital or respiratory tracts and, in most cases, mycoplasmas infect the host persistently. in hiv-infected individuals the prevalence and role of genital mycoplasmas has not been well studied. to investigate the six species of mycoplasma and the risk factors for infection in jiangsu province, first-void urine and venous blood samples were collected and epidemiological questionnaires were administered after informed cons ... | 2015 | 25792346 |
| in vitro antimicrobial susceptibility of mycoplasma hominis genital isolates. | | 2015 | 25791859 |
| isolation and molecular identification of mycoplasma hominis in infertile female and male reproductive system. | infection of urogenital system with mycoplasma potentially affect reproductive system and increases infants mortalities. therefore, detection of these organisms is an important issue that should be considered and appropriate diagnostic methods should be used to identify these microorganisms. in the female reproductive system, infection can affect different parts of the cervix, endometrium, and fallopian tube. the extent of this infection in different diseases and its pathogenesis might be relate ... | 2014 | 25738116 |
| mycoplasma hominis ssp. associated endocarditis with myocardial necrosis in an alpaca (vicugna pacos) in manitoba in 2011. | severe endocarditis with myonecrosis, moderate to severe pleural and pericardial effusions, and mild ascites were found on necropsy in 3 alpacas. mycoplasma hominis ssp. was detected on polymerase chain reaction (pcr) of fresh affected endocardial tissue in 1 alpaca. | 2015 | 25694661 |
| identification of a gene in mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection. | microbial invasion of the amniotic cavity is associated with spontaneous preterm labor and adverse pregnancy outcome, and mycoplasma hominis often is present. however, the pathogenic process by which m hominis invades the amniotic cavity and gestational tissues, often resulting in chorioamnionitis and preterm birth, remains unknown. we hypothesized that strains of m hominis vary genetically with regards to their potential to invade and colonize the amniotic cavity and placenta. | 2015 | 25637842 |
| genome-wide analysis of mycoplasma hominis for the identification of putative therapeutic targets. | ever increasing propensity of antibiotic resistance among pathogenic bacteria raises the demand for the development of novel therapeutic agents to control this grave problem. advances in the field of bioinformatics, genomics, and proteomics have greatly facilitated the discovery of alternative drugs by swift identification of new drug targets. in the present study, we employed comparative genomics and metabolic pathway analysis with an aim of identifying therapeutic targets in mycoplasma hominis ... | 2014 | 25574133 |
| [the comparison of tests for qualitative evaluation of ureaplasma parvum, mycoplasma hominis: "mycoplasma duo", "ureaplasma microtest", "mycoplasma microtest" and "amplisens-florocenosis-mycoplasma-fl"]. | the genital mycoplasma is an opportunistic bacteria and its detection is to be implemented in qualitative format. the study was organized to compare reagents kits "mycoplasma duo", "ureaplasma microtest", "mycoplasma microtest" and "amplisens-florocenosis-mycoplasma-fl". the study resulted in high indicators of diagnostic sensitivity and diagnostic specificity for all kits. at that, the lowest indicators were registered under application of "mycoplasma duo" kit. the study reveled correlation of ... | 2014 | 25552055 |
| a new case of mycoplasma hominis mediastinitis and sternal osteitis after cardiac surgery. | we report a case of nosocomial mediastinitis and sternal osteitis due to m. hominis after open-heart surgery in an immuno-competent patient. this infection has been diagnosed by incubating the culture media for an extended period of time, and sequencing 16s rdna directly from the clinical samples. | 2015 | 25532483 |
| an 8-month history of meningitis in an extremely low birth weight infant? - long-lasting infection with ureaplasma parvum. | ureaplasma spp. have been implicated in the pathogenesis of both preterm labor and neonatal morbidity including pneumonia and sepsis and the development of chronic lung disease of prematurity. data on ureaplasma meningitis are limited and partly controversially discussed. | 2015 | 25525814 |
| autoinfection as a cause of postpartum subdural empyema due to mycoplasma hominis. | mycoplasma hominis is a commensal of the genitourinary tract, which is infrequently associated with urogenital infections. extra-urogenital infections due to m. hominis are rare. here, we report an unusual case of m. hominis subdural empyema in a woman occurring shortly after delivery. the patient presented with symptoms suggestive of bacterial meningitis. spinal imaging revealed a subdural empyema that required neurosurgical intervention. cultures from intraoperatively obtained biopsies identif ... | 2015 | 25491170 |
| a case report of mycoplasma hominis brain abscess identified by maldi-tof mass spectrometry. | we report the case of a 43-year-old man with a mycoplasma hominis brain abscess occurring after a cranial trauma, which was identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms). the presence of colonies on classic blood agar plates and the use of maldi-tof ms, a valuable diagnostic tool that identified m. hominis due to its presence in the vitek ms database, allowed the rapid diagnosis of this infection. | 2014 | 25449252 |
| ureaplasma species and mycoplasma hominis in cervical fluid of pregnancies complicated by preterm prelabor rupture of membranes. | to evaluate ureaplasma species and mycoplasma hominis dna in the cervical fluid and their association with microbial invasion of the amniotic cavity (miac) and/or histological chorioamnionitis (hca) in pregnancies complicated by preterm prelabor rupture of membranes (pprom). | 2016 | 25369771 |
| performance of four commercial kits for laboratory diagnosis of urogenital mollicute infection. | we have empirical evidence for the unsatisfactory performance of the most accessible commercial kits for mollicute culture. we aimed to evaluate the performance of the 4 commercial kits available for diagnosis of urogenital mollicute infections, compared with culture media (cmmc) produced in our research laboratory. we demonstrated that the newprov kit had a sensitivity of 17% for ureaplasma sp. and 33% for mycoplasma hominis. the laborclin kit presented a sensitivity of 25% for ureaplasma sp., ... | 2014 | 25188579 |
| prevalence and antimicrobial susceptibility of ureaplasma urealyticum and mycoplasma hominis in female outpatients, 2009-2013. | the aim of this study was to estimate the prevalence and antimicrobial susceptibility of ureaplasma urealyticum and mycoplasma hominis among female outpatients treated for genital infection at a chinese hospital from january 1, 2009 to december 31, 2013. | 2016 | 25081985 |
| [measurement of genital mycoplasma concentration by using a microbiological and molecular-biological methods]. | establishment of ratios that would allow to execute recalculation of mycoplasma concentration from cfu/ml and/or ccu/ml into units obtained during pcr analysis--geq/ml. | 2014 | 25051693 |
| epidemiological investigation and antimicrobial susceptibility analysis of ureaplasma species and mycoplasma hominis in outpatients with genital manifestations. | the aim of this study was to assess the prevalence and drug resistance of ureaplasma species and mycoplasma hominis in outpatients with genital manifestation from 2005 to 2013 in hangzhou, china. | 2014 | 24982440 |
| molecular mechanism of fluoroquinolones resistance in mycoplasma hominis clinical isolates. | to evaluate the molecular mechanism of fluoroquinolones resistance in mycoplasma hominis (mh) clinical strains isolated from urogenital specimens. 15 mh clinical isolates with different phenotypes of resistance to fluoroquinolones antibiotics were screened for mutations in the quinolone resistance-determining regions (qrdrs) of dna gyrase (gyra and gyrb) and topoisomerase iv (parc and pare) in comparison with the reference strain pg21, which is susceptible to fluoroquinolones antibiotics. 15 mh ... | 2014 | 24948939 |
| a potential pathogenic factor from mycoplasma hominis is a tlr2-dependent, macrophage-activating, p50-related adhesin. | mycoplasma hominis has been implicated in many inflammatory conditions of the human urogenital tract in particular amniotic infections that lead to fetal and neonatal disease and pre-term labor. the mechanisms responsible are poorly defined. | 2014 | 24938999 |
| intra-abdominal mycoplasma hominis infection in a liver transplant recipient: a case report. | | 2014 | 24858617 |
| postoperative mycoplasma hominis infections after neurosurgical intervention. | mycoplasma hominis is a rare cause of infection after neurosurgical procedures. the mycoplasma genus contains the smallest bacteria discovered to date. mycoplasma are atypical bacteria that lack a cell wall, a feature that complicates both diagnosis and treatment. the gram stain and some types of culture media fail to identify these organisms, and typical broad-spectrum antibiotic regimens are ineffective because they act on cell wall metabolism. mycoplasma hominis commonly colonizes the genitou ... | 2014 | 24856879 |
| treatment of genital mycoplasma in colonized pregnant women in late pregnancy is associated with a lower rate of premature labour and neonatal complications. | mycoplasma hominis and ureaplasma spp. may colonize the human genital tract and have been associated with adverse pregnancy outcomes such as preterm labour and preterm premature rupture of membranes. however, as these bacteria can reside in the normal vaginal flora, there are controversies regarding their true role during pregnancy and so the need to treat these organisms. we therefore conducted a retrospective analysis to evaluate the treatment of genital mycoplasma in 5377 pregnant patients sh ... | 2014 | 24849820 |
| vacuum-assisted closure (vac)-instill(®) with continuous irrigation for the treatment of mycoplasma hominis mediastinitis. | a 56-year-old patient who underwent ascending aorta replacement postoperatively developed mediastinitis with atypical mycoplasma hominis. we present the first successful treatment of m. hominis mediastinitis after cardiac surgery with vacuum-assisted closure (vac)-instill(®) therapy combined with dilute antiseptic irrigation for bacterial eradication. | 2015 | 24684727 |