| [treatment of brucellosis associated with corynebacterium parvum infection in mice with antibiotics (tetracycline, ampicillin, trimethoprim-sulfamethoxazole)]. | | 1972 | 4639772 |
| protection by corynebacterium parvum against tumour cells injected intravenously. | | 1972 | 4648182 |
| the role of anaerobic coryneforms on specific and non-specific immunological reactions. i. effect on particle clearance and humoral and cell-mediated immunological responses. | | 1973 | 4717941 |
| lympho-reticular stimulatory properties of corynebacterium parvum and related bacteria. | | 1973 | 4726332 |
| microcolony size of microbes on human skin. | | 1973 | 4726334 |
| preliminary results of nonspecific immunotherapy for lung cancer. | | 1973 | 4729331 |
| lasting rejection of mammary adenocarcinoma cell tumors in dba-2 mice with intratumor injection of killed corynebacterium parvum. | | 1974 | 4810906 |
| the effect of transplanted methylcholanthrene induced fibrosarcomata and corynebacterium parvum on the immune response of cba and a-hej mice to thymus dependent and independent antigens. | | 1974 | 4820942 |
| corynebacterium parvum: a synonym for propionibacterium acnes? | | 1974 | 4826546 |
| anti-tumour effect in vitro of lymphocytes and macrophages from mice treated with corynebacterium parvum. | | 1974 | 4830143 |
| proceedings: immunotherapy of moloney sarcoma virus tumours in mice with corynebacterium parvum. | | 1974 | 4832648 |
| increased phagocytic cell activity and anaemia in corynebacterium parvum treated mice. | | 1974 | 4835797 |
| [stimulating effect on in vitro cell growth of spleen cells from tumor bearing mice]. | | 1974 | 4849772 |
| chronic meningitis caused by propionibacterium acnes. a potentially important clinical entity. | | 1974 | 4858158 |
| transitional forms of corynebacterium acnes in disease. | a clear-cut triad of sequential corynebacterium acnes transitional forms from disease has been discovered. this entity includes three major forms which are capable of stabilization in culture, the spherical, the intermediate, and the definitive c. acnes. during conversion or reversion among the three forms, a variety of forms with mixed characteristics was observed. the spherical form was gram-negative and osmotically fragile, but it possessed a vestigial cell wall and mesosomes which excluded i ... | 1969 | 4886295 |
| chronic granulomatous infection of the legs associated with corynebacterium acnes. | | 1969 | 4893869 |
| comparative diagnostic methods for detecting lactate utilization by corynebacterium acnes. | | 1969 | 4896271 |
| the intestinal flora of colonization-resistant mice. | to facilitate the isolation of anaerobes from cultures in which swarming organisms were present roux flasks were adapted to provide anaerobic conditions. using these flasks, five species of anaerobes were isolated from the caecum of mice resistant to colonization with escherichia coli and other gram-negative organisms. these species accounted for the majority of organisms seen in films of caecal material. no aerobes were isolated and the flora of these mice apparently consisted of a limited numb ... | 1971 | 4937854 |
| [sensitivity of corynebacterium acnes toward antibiotics]. | | 1969 | 4976652 |
| differentiation of two groups of corynebacterium acnes. | one hundred and forty-three strains of corynebacterium acnes, isolated from human skin and acne lesions, were compared with three strains of propionibacterium acnes from the american type culture collection. the 146 organisms could be separated into two groups. members of the larger group (129 strains) hydrolyzed gelatin and usually produced indole, gel-in(+), but were unable to ferment trehalose, maltose, or sucrose, tms(-). the deoxyribonucleic acid from selected strains of this group had an a ... | 1970 | 4984071 |
| control of free fatty acids in human surface lipids by corynebacterium acnes. | | 1971 | 4997367 |
| further observations on the effect of c. parvum and anti-tumour globulin on syngeneically transplanted mouse tumours. | | 1972 | 5038327 |
| [importance of specific and nonspecific immunity in anti-tumor defense]. | | 1972 | 5050875 |
| "in vitro" effect of soap containing hexachlorophene on growth and ultrastructure of corynebacterium acnes. | | 1972 | 5055189 |
| cell wall composition and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria, and strains of arachnia propionica. | eighty strains of anaerobic coryneforms were compared with 29 strains of classical propionibacteria and 8 strains of arachnia propionica by cell wall analysis, deoxyribonucleic acid (dna) base compositions, and nucleotide sequence similarities. the anaerobic coryneforms have dna base compositions in the range of 58 to 64% guanine + cytosine (gc) and show at least three homology groups. the largest group corresponds to organisms identified as propionibacterium acnes and shows about 50% homology t ... | 1972 | 5062339 |
| latent corynebacterium acnes infection of bone marrow. | | 1969 | 5355456 |
| ultrastructural changes in bacteria isolated from cases of leprosy. | one of two groups of rod-shaped bacteria (bacilli) isolated from cases of human leprosy have been found, under certain cultural conditions, to give rise to unusual phenotypes. in electron micrographs of ultrathin sections and negatively stained whole cells of these osmotically fragile bacteria, ultrastructural anomalies are apparent and seem to arise from disorder in the process(es) of septum formation or cell envelope biosynthesis or both. two of the four strains examined are related to coryneb ... | 1969 | 5359609 |
| effect of fatty acids on the growth of corynebacterium acnes in vitro. | | 1970 | 5416678 |
| corynebacterium acnes from human skin. identification by morphologic, cultural, biochemical, serological, and chromatographic methods. | | 1970 | 5416791 |
| liver abscess due to corynebacterium acnes. diphtheroid as pathogen. | | 1971 | 5545913 |
| [occurrence of neuraminidase in corynebacterium acnes]. | | 1971 | 5561975 |
| characterization of the c15 branched-chain fatty acids of corynebacterium acnes by gas chromatography. | | 1968 | 5636822 |
| lipolytic activity of corynebacterium acnes. | | 1968 | 5673309 |
| [chemical analysis of the cell wall of corynebacterium acnes and c. parvum]. | | 1968 | 5744273 |
| triglyceride hydrolysis by corynebacterium acnes in vitro. | | 1969 | 5774353 |
| tryptophanase in diverse bacterial species. | the distribution of tryptophanase was studied. the highest observed specific activity, mumoles per minute per milligram (dry weight) cells, is given in parentheses after each species. tryptophanase was inducible and repressible in escherichia coli (.914), paracolobactrum coliforme (.210), proteus vulgaris (.146), aeromonas liquefaciens (.030), photobacterium harveyi (.035), sphaerophorus varius (.021), bacteroides sp. (.048), and corynebacterium acnes (.042). the enzyme was constitutive and nonr ... | 1969 | 5781572 |
| role of extracellular ribonuclease in growth of corynebacterium acnes. | | 1969 | 5796118 |
| scalp pustules due to corynebacterium acnes. | | 1967 | 6046393 |
| cultural characteristics and fatty acid composition of corynebacterium acnes. | a detailed study of the cultural characteristics and cellular fatty acid composition of 27 isolates of corynebacterium acnes was performed to establish the properties by which this organism may be identified and characterized. the fatty acids were extracted directly from whole cells and examined as methyl esters by gas-liquid chromatography. each strain possessed a similar fatty acid profile which was characterized by a large percentage of c15 branched-chain acid. uniformity in certain biochemic ... | 1967 | 6057790 |
| antitumor therapy based on the use of an immune modulator, arginine butyrate and interferon. | the analysis of the likely physiological role of interferon during pregnancy and antitumor protection can be employed in developing a new strategy in antitumor therapy. indeed, pretreatment of the patients with a potent immune stimulation compensates to some extent interferon's immune repressive effects. through the modulation of the cytoskeleton, interferon enhances macrophage activity. moreover, butyrate by its own effect on the malignant phenotype increases interferon sensitivity in a number ... | 1984 | 6085812 |
| an improved macrophage spreading assay--a simple and effective measure of activation. | the development of a quantitative spreading assay of macrophage activation is described. the assay involved incubation of macrophages on glass coverslips for 1 hour and assessment of cell size using a microscope attached to a microcomputer-assisted digitising system which allowed the diameter of 200 cells to be assessed within 10 minutes. mouse peritoneal macrophages were used in the development of the assay. internal consistency of the assay was shown by minimal inter-observer, intra-observer a ... | 1984 | 6086500 |
| antimicrobial susceptibility of anaerobic bacteria in sweden in 1983. | this review is concerned with anaerobic bacteria and antimicrobial susceptibility. data on the susceptibility to different antimicrobials of anaerobic isolates in sweden during 1983 is presented. among the different bacterial groups, clostridium perfringens, propionibacteria, anaerobic cocci and curved rods were found to be susceptible to beta-lactam antibiotics, clindamycin and chloramphenicol. c. difficile was susceptible to benzylpenicillin and imipenem, but resistant to cefoxitin. most c. di ... | 1984 | 6100139 |
| do anaerobes cause urinary tract infection? | | 1980 | 6101823 |
| autoantibodies in cancer patients given corynebacterium parvum/levamisole immunotherapy. | | 1980 | 6103412 |
| haemagglutinating activity of propionibacterium acnes isolated from the human oral cavity. | | 1980 | 6110490 |
| cellular basis for the loss of carcinogen from methylcholanthrene-impregnated millipore membrane. | millipore 'discs' impregnated with methylcholanthrene dissolved in wax or in crystalline form implanted subcutaneously in mice evoke an early intense macrophage and giant cell reaction; later the discs become covered with connective tissue, and eventually fibrosarcomas develop in their vicinity. studies with tritium-labelled material show that under these conditions methylcholanthrene (mc) is removed from the discs and broken down rapidly (half life about 7 days) to a water-soluble product, whic ... | 1981 | 6111799 |
| in vitro reactivity of natural killer (nk) cells against cryptococcus neoformans. | | 1982 | 6120974 |
| transplantation model for study of microbiology of human skin. | | 1982 | 6124748 |
| an enumeration of black-pigmented bacteroides in human subgingival material using a selective medium. | | 1982 | 6125274 |
| distribution of surface fimbriae in species of the genus propionibacterium. | | 1982 | 6129070 |
| mite fauna, housedust, and kawasaki disease. | | 1983 | 6134934 |
| variant strain of propionibacterium acnes: a clue to the aetiology of kawasaki disease. | by means of anaerobic culture for 3-4 weeks a variant strain of propionibacterium acnes was isolated from one lymph-node biopsy specimen, and from blood samples of five of twenty-three patients with early kawasaki disease, but from only one of fifteen blood samples from patients after 8 days' illness. no anaerobe was isolated from sixty age-matched controls with various disorders, but the same bacillus with the same serotype was isolated from house-dust mites from six patients' homes. patients h ... | 1983 | 6140493 |
| aerobic and anaerobic bacteriologic features of serous otitis media in children. | aspirates of serous ear fluids from 57 children were examined for aerobic and anaerobic bacteria. bacterial growth was noted in 23 patients (40 per cent). aerobic organisms only were recovered in 13 aspirates (57 per cent of the culture-positive aspirates); anaerobic bacteria in four (17 per cent); and mixed aerobic and anaerobic bacteria in six (26 per cent). a total of 45 bacterial isolates were recovered, accounting for 2.0 isolates per specimen (1.4 aerobes and 0.6 anaerobe). there were a to ... | 1983 | 6140881 |
| [anaerobic sepsis]. | | 1983 | 6141318 |
| immunomodulation by corynebacterium parvum in normal humans. | four normal human donors were immunized with 2 mg of heat-killed corynebacterium parvum by subcutaneous and intracutaneous injections, and lymphocyte surface markers, antibody-dependent (adcc), and spontaneous cell-mediated (scmc) cytotoxicities followed for a 28-day period. although no changes were observed in the relative proportions of b, t, and fc receptor-carrying lymphocytes, two t cell subpopulations, namely, the autologous rosette-forming cells and active rosette-forming cells, both exhi ... | 1980 | 6154095 |
| tumor-immunotherapeutic efficacy of serratia marcescens polyribosomes. | the ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous sad2 fibrosarcomas in dba/2 mice were evaluated. suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with serratia marcescens being superior to escherichia coli, streptococcus pneumoniae, mycobacterium bovis (pasteur), mycobacterium smegmatis, and propionibacterium acnes (formerly corynebacte ... | 1980 | 6154530 |
| immunostimulation and host resistance against infection: therapeutic perspectives. | | 1980 | 6157316 |
| species-restricted effects of human and mouse lymphokines on macrophages. | lymphokines produced by antigenic or mitogenic stimulation of human, guinea pig and mouse lymphocytes were tested for their effects on monocytes or macrophages of the same and heterologous species, to determine whether there is any species restriction in their reactivity. supernatants from lymphocyte cultures were tested for migration inhibitory activity in an indirect agarose microdroplet assay and for their ability to augument cytolytic activity of macrophages or monocytes in a [3h]thymidine-r ... | 1980 | 6157542 |
| human peripheral null lymphocytes. ii. producers of type-1 interferon upon stimulation with tumor cells, herpes simplex virus and corynebacterium parvum. | human blood lymphocytes, exposed for 6 to 24 h in vitro to tumor cells (k 562, igr3, l1210), herpes simplex virus type 1 (hsv) or corynebacterium parvum (cp), produced high levels of anti-viral activity which was identified as type-1 interferon (if). in mixed lymphocyte tumor cell cultures (mltc), the generated type-1 if was definitely shown to originate from the lymphocytes and not from the tumor cells. supplementation of leukocyte cultures with 10% fetal calf serum instead 10% human ab serum h ... | 1980 | 6157543 |
| cancer immunology. | | 1980 | 6157656 |
| effective outpatient combination chemotherapy for advanced cancer of the head and neck. | forty-six patients with advanced cancer of the head and neck, 42 of whom had failed conventional radiotherapy or surgical excision, or both, were treated on an outpatient basis with a regimen consisting of bleomycin, methotrexate and cis-diamminedichloroplatinum ii. objective responses were noted in 29 patients, with eight having apparent complete remissions. the median duration of partial response was only five months, but the median duration of complete remission was 11 months. median survival ... | 1980 | 6159692 |
| immunotherapy and genitourinary neoplasia. | | 1980 | 6161466 |
| modulation of the rats' immune status by monoassociation with anaerobic bacteria. | the capacity of a pure culture of anaerobic intestinal bacteria to influence the host's cellular and humoral immune systems was investigated with germfree, monoassociated, and conventionally reared rats. monoassociation of germfree rats with bacteroides fragilis stimulated the production of serum gamma globulin, agglutinating antibodies, and an apparent igg (immunoelectrophoresis) band. a comparison of the in vitro blastogenic potential of lymphocytes (spleen cells and mesenteric lymph node cell ... | 1980 | 6161685 |
| effects of topical erythromycin on aerobic and anaerobic surface flora. | the contents of acne lesions from 30 men with inflammatory acne vulgaris, obtained before and at the conclusion of 4 weeks of topical 2% erythromycin therapy, were cultured on aerobic and anaerobic plates. sensitivity testing of cultures was performed with discs containing 50 mg erythromycin, in order to ascertain the prevalence of erythromycin-resistant strains of propionibacterium acnes and aerobic micrococci. the percentages of patients in whom erythromycin-resistant micrococci could be isola ... | 1980 | 6162344 |
| benzoyl peroxide. | the mode of action of benzoyl peroxide in acne is three-fold, i.e. sebostatic, comedolytic and inhibitory to p. acnes in-vivo. benzoyl peroxide is the topical treatment of choice in acne vulgaris. this agent is well tolerated by most patients. primary irritant dermatitis can be avoided by less frequent application and the true incidence of contact sensitivity is low. the gel preparation has achieved a high degree of cosmetic acceptability. a synergistic effect with retinoic acid can be demonstra ... | 1980 | 6162349 |
| [therapeutic use of immunostimulants against infections (author's transl)]. | | 1980 | 6162607 |
| interferon production by corynebacterium parvum and bcg-activated murine spleen macrophages. | macrophages were identified to be a major source of interferon produced in murine spleen cell cultures after intravenous injection of corynebacterium parvum (c. parvum), strain cn 6134 or bacille calmette guérin (bcg). another strain of c. parvum, cn 5888, which lacks res stimulating activity and adjuvant activity in vivo, was not effective when injected intravenously. protein synthesis was required for interferon activity to be produced and protein synthesis was also required for the antiviral ... | 1980 | 6162779 |
| activated macrophages mediate interferon-independent inhibition of herpes simplex virus. | | 1981 | 6164494 |
| role of macrophage in in vitro augmentation of rat, mouse, and human natural killer activities. | requirement for macrophages in in vitro augmentation, by interferon (ifn), polyinosinic-polycytidylic acid (poly i:c), or corynebacterium parvum, of rat, mouse, and human natural killer (nk) activities was examined. several differences were seen among the species. mouse nk activity demonstrated some lability at 37 degrees c and a strict macrophage requirement for in vitro production of ifn, and augmentation of nk activity was demonstrated by either poly i:c or c. parvum. in contrast, human perip ... | 1981 | 6164813 |
| protection of mice against mouse hepatitis virus by corynebacterium parvum. | c57bl/6 mice that are highly susceptible to infection with mouse hepatitis virus type 3 were protected against intraperitoneal viral infection by simultaneous intraperitoneal injection of corynebacterium parvum. no protection was observed when c. parvum was given intravenously or when it was injected intraperitoneally 3 days before viral infection. protective effects were, however, consistently found when c. parvum was given 2 h before or 2 h after viral infection. activity was seen only against ... | 1981 | 6166566 |
| the effect of benzoyl peroxide on acne. | a double-blind study of two commonly used (5%) benzoyl peroxide-containing preparations showed that they were equally effective in the treatment of acne. with these treatments there was a reduction in p. acnes, micrococcaceae and surface-free fatty acids. these data support the continued use of benzoyl peroxide preparations in the treatment of acne. | 1981 | 6167116 |
| the relationship between bacteria and the abnormal follicular keratinization in acne vulgaris. | the structural organization and bacteriological profile of follicular casts and early comedones in prepuberal children were investigated. follicular casts were present in all samples but were not as abundant as usually seen in older individuals with acne. when examined with the light microscope, all casts and comedones were composed of numerous layers of horny cells and sebum, but were devoid of bacteria. neither follicular casts nor comedones yielded bacteria when cultured. electron microscopy ... | 1981 | 6167647 |
| intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: effects on cytotoxicity of tumor-associated macrophages and nk cells. | | 1981 | 6168590 |
| bacteriologic investigation and histologic observations of variably acid-fast bacteria in three cases of cutaneous kaposi's sarcoma. | skin biopsy specimens from 3 consecutive patients with lesions of kaposi's sarcoma limited to the skin were cultured for bacteria, and also examined histopathologically for the presence of acid-fast wall deficient (cwd) bacteria. corynebacterium sp and propionibacterium acnes were isolated from two repeated cultures from the first case. both staphylococcus epidermidis and streptococcus viridans were isolated from the second case. bacteriologic culture of the third case was negative. utilizing th ... | 1981 | 6169593 |
| the induction of at least two distinct types of interferon in mouse spleen cell cultures by corynebacterium parvum. | | 1981 | 6170460 |
| immunotherapy of sarcomas. | numerous attempts have been made at immunotherapy of sarcomas in man, and in most of these, tumor cells were used as a source of antigen. the cells were given by direct immunization with an adjuvant such as bcg or in adoptive immunotherapy trials in which tumor-immunized donors were a potential source of immune cells. these series of studies have shown consistent evidence of effect on the immune response of the patients to tumor antigens but no consistent clinical effect. nonspecific immunothera ... | 1981 | 6170891 |
| effect of immunostimulating agents on viral infections. | | 1981 | 6171144 |
| a comparison of the antiproliferative and antiviral activities of alpha-, beta- and gamma-interferons: description of a unified assay for comparing both effects simultaneously. | an assay system is described which allows simultaneous measurement of antiviral (av) and antiproliferative (ap) activities of various interferons (ifns) with the same indicator cells and tests one biological function, i.e. the reduction of dna synthesis. human ifn-alpha, -beta, and -gamma preparations were investigated for their respective av and ap activities. in repeated independent experiments the ap:av ratio was found to be constant for each ifn preparation. however, striking difference in t ... | 1981 | 6174633 |
| specific unresponsiveness to corynebacterium parvum as measured by delayed hypersensitivity. | in order to induce specific unresponsiveness to c. parvum mice were given seven daily i.v./i.p. injections of a high dose of the vaccine, or were given a single dose i.v. injection of c. parvum followed by an i.p. injection of cyclophosphamide (cy). mice given the high-dose procedure had a significant level of residual footpad reactivity to c. parvum challenge, but subsequent sensitizing injections did not stimulate delayed hypersensitivity (dh). in contrast, mice given c. parvum and cy did not ... | 1981 | 6176532 |
| immunopotentiation of allergic contact dermatitis in the guinea pig with c. parvum (p. acnes). | | 1981 | 6177174 |
| murine lymph node natural killer cells: regulatory mechanisms of activation or suppression. | the kinetics and organ distribution patterns of lymph node natural killer (nk) cell activation or suppression were found to vary according to the type, dose, and route of administration of corynebacterium parvum or polyinosinic-polycytidylic acid (poly i . poly c). activation of lymph node nk cells by local injections of c. parvum into the footpad or the peritoneum was restricted to the regional lymph nodes; contralateral and distant lymph nodes were not involved. this selectivity persisted even ... | 1982 | 6180211 |
| interferons and bacterial infections. | viruses have been established initially as interferon inducers and interferons have been considered to be antiviral proteins only. by our article we wish to draw attention to two observations: a) bacteria and derivatives thereof also are inducing the production of interferon b) interferons activate a number of defense mechanisms that are of potential relevance in antibacterial resistance. these two observations are not new. however, we believe, they deserve renewed attention within the framework ... | 1982 | 6181288 |
| propionibacterium acnes infection complicating craniotomy. | | 1980 | 6182220 |
| antitumor effect of arginine butyrate in conjunction with corynebacterium parvum and interferon. | the antitumor effect of arginine butyrate, used alone or in conjunction with interferon (ifn), was studied using randomly selected swiss mice inoculated i.p. with 10(6) 180 tg crocker tumor cells. the results of these different therapeutic regimens were estimated by tumor incidence at 10 days, by the time necessary to protect 50% of the animals, and by the final survival rate. combined treatment by ifn and arginine butyrate was effective; but in order to compensate for ifn's immune repressive ef ... | 1982 | 6183228 |
| modulation of suppressor mechanisms in allergic contact dermatitis: 5. evidence that inhibition of suppressor t lymphocytes by corynebacterium parvum is mediated by interferon. | using a contact hypersensitivity model in balb/c mice we have previously been able to show that corynebacterium parvum or c. parvum serum (c.p.s.) of mice treated 24 hr before with c. parvum inhibited the suppressor t-lymphocyte (ts-cell) response induced by epicutaneous antigen overload with 2,4-dinitrofluorobenzene (dnfb) or by i.v. injection of 2,4-dinitrobenzene sulfonic acid (dnbso3) without inhibition of the t effector cell response (tdh-cell). in the present investigation we further analy ... | 1982 | 6183368 |
| treatment of advanced renal cell carcinoma. | | 1982 | 6183675 |
| endotoxin-induced release of tumour necrosis factor and interferon in vivo is inhibited by prior adrenoceptor blockade. | the effect of alpha- and beta-adrenoceptor blocking agents on endotoxin-induced release of tumour necrosis factor (tnf), and of interferon in the circulation of corynebacterium parvum-treated mice was the subject of this study. tnf was quantified after injection of tnf containing heated serum (tns) into meth a sarcoma-bearing mice by determining colour, extent, and incidence of haemorrhagic necrosis. the release of tnf was weakly inhibited by the competitive alpha-blocker phentolamine and the be ... | 1982 | 6186366 |
| suppression of in vitro maintenance and interferon-mediated augmentation of natural killer cell activity by adherent peritoneal cells from normal mice. | the ability of adherent peritoneal cells (apc) to inhibit murine natural killer (nk) cell activity was examined. nylon wool-nonadherent splenic effector cells were incubated overnight with or without different numbers of apc. nk activity was then measured against yac-1 in a 4-hr 51cr-release cytotoxicity assay. proteose peptone-elicited or unstimulated resident apc from normal mice markedly suppressed nk activity of splenic effector cells in the presence or absence of exogenously added interfero ... | 1983 | 6187831 |
| interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon. | the interferon (ifn)-induced enzyme 2-5a synthetase was elevated in mononuclear cells from both serum ifn-positive and -negative systemic lupus erythematosus (sle) patients. this suggests that a much higher percentage of patients than previously thought produce endogenous ifn. these results may partly explain findings that mononuclear cells from sle patients are deficient in ifn production in vitro in response to certain ifn inducers. although normal lymphocytes can produce an acid-labile alpha ... | 1983 | 6189954 |
| effects of various coryneforms on mononuclear phagocyte system function and on production of tumour necrosis factor in mice. | vaccines of 6 strains of the genera corynebacterium and propionibacterium were tested for induction of hepatosplenomegaly and stimulation of clearance of injected colloidal carbon and viable listeria monocytogenes. these effects were compared with the ability of these strains to support the endotoxin-induced liberation of tumour necrosis factor, interferon and heat-stable cytostatic factors in mouse circulation. five strains caused good stimulation of macrophage functions and induced high levels ... | 1983 | 6190428 |
| [immunology - results of two decades of immunological research]. | the discipline of immunology has made very rapid progress during the past twenty years. a general introductory part was followed by a discussion of immunological components in resistance. subsequently, the importance of controlling the immunological system was stressed. the significance of the network theory was briefly referred to. attention was then drawn to specific and non-specific stimulation of the immune response, which are essential both in theory and in actual practice. a number of inst ... | 1983 | 6191405 |
| regulation of cytotoxic reactivity to minor histocompatibility antigens by administration of corynebacterium parvum. | b10.br(h-2k) mice were primed with h-2-identical allogeneic cba/j(h-2k) spleen cells and restimulated in vitro 14 days later to generate specific secondary cytotoxic lymphocytes. a single intravenous injection of primed mice with 700 micrograms of corynebacterium parvum 7 days after alloimmunization markedly inhibited the subsequent secondary in vitro generation of cytotoxic cells. in addition, regulatory spleen cells were detected in alloimmunized c-parvum-injected mice that prevented the resti ... | 1983 | 6191416 |
| inhibition of natural killer cell lysis by natural killer-inhibitory substance: mechanism of suppression. | the mechanism of suppression of nk-mediated lysis by a soluble product of peritoneal cells (nk-is, natural killer-inhibitory substance) was investigated. pretreatment of effector cells resulted in depressed nk lysis while pretreatment of targets had no effect, indicating suppression is due to alterations in effector cell function rather than changes in target cells. nk-is had no effect on the formation of conjugates between effectors and nk-susceptible targets. when nk-is was added to effector-t ... | 1983 | 6191875 |
| effect of coordinated therapeutic assays using c. parvum, interferon and arginine butyrate on spontaneous disease and survival of akr mice. | akr mice, known to develop spontaneous leukemia in almost 100% of cases, were studied throughout their life-span. different treatments combining a potent immune stimulator, corynebacterium parvum (cp), with interferon (ifn) and arginine butyrate were initiated at the 15th week of life. in a preliminary series of experiments, cp (200 micrograms), ifn (20,000 units) and butyrate 50 mm) were employed in a well-defined chronological order. in controls, the mean survival time (mst) was 35.17 +/- 1.67 ... | 1983 | 6193071 |
| immunotherapy of ovarian cancer. | | 1983 | 6193921 |
| isolation of anaerobic and aerobic bacteria from clean surgical wounds: an experimental and clinical study. | a pad imprint method was evaluated for quantitative sampling of anaerobic and aerobic bacteria from clean surgical wounds. the best recovery of bacteria from the pads was obtained when they were treated with a rinsing solution in a 'stomacher' apparatus. pads of three different fabrics were compared, but no difference was noted in their efficiency in sampling anaerobic and aerobic bacteria from clean surgical wounds. sampling of known quantities of staphylococcus aureus from experimental wounds ... | 1983 | 6195222 |
| mode of protection of mice against herpes simplex virus type 2 infection by propionibacterium. | we compared various strains of propionibacterium with regard to protection of young adult mice against lethal infection with herpes simplex virus type 2 (hsv-2). propionibacterium acnes, p. granulosum, and p. avidum were protective, while p. acidi-propionici and p. lymphophilum were ineffective. the protective effect proved to be in the cell wall fraction. attempts were made to elucidate possible mechanisms of the protection using both effective and ineffective strains. the results strongly sugg ... | 1983 | 6195512 |
| immunologic therapies of kidney carcinoma. | | 1983 | 6198729 |
| [antitumor effect of corynebacterium parvum and poly iclc on experimental brain tumors]. | | 1983 | 6201759 |
| immunostimulation: synthetic and biological modulators of immunity. | | 1984 | 6203479 |