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[clinical case of the month. an unusual sepsis].lemierre's syndrome is a rare, but significant pathology to recognize. it most often affects young patients in good health; a late diagnosis can be fatal. it consists in an anaerobic septicemia (usually, fusobacterium necrophorum) originating from a suppurative thrombophlebitis of the internal jugular vein. infection occurs during a common sore throat and spreads by contiguity. the clinical presentation is a sepsis with pulmonary embolisations, but other sites of dissemination can also occur. tr ...201624053095
the oral microbial community of gingivitis and lumpy jaw in captive macropods.gingivitis and lumpy jaw are diseases of polymicrobial aetiology. although fusobacterium necrophorum has been associated with these diseases in macropods, little is known about other organisms associated with these diseases in this animal species. pcr-dgge analysis revealed the potential pathogens associated with gingivitis and lumpy jaw in macropods. pcr-dgge profile comparison between the healthy and disease groups indicated a shift in the oral bacterial community structures with similarity co ...201324012349
fusobacterium necrophorum in an abdominal aortic aneurysm, treated by once daily ertapenem.inflammatory aneurysms may make up a small percentage of the total number of abdominal aortic aneurysms, but they present their own unique challenges. we present a case of a 65-year-old man whose aneurysm was found to be colonized by fusobacterium necrophorum.201223997565
establishment of a new murine model of liver abscess induced by fusobacterium necrophorum injected into the caudal vein.anaerobic bacterial infection is often accompanied by abscess formation; however, few in vivo studies have been published with descriptive data specifically evaluating antimicrobial activity in the presence of abscesses. the aim of this study was to establish a murine model of anaerobic infection with abscess formation and to verify the utility of this model for evaluating the in vivo efficacy of an antimicrobial agent. a clinical isolate of fusobacterium necrophorum was inoculated into the caud ...201323973984
fusobacterium necrophorum: a rare cause of hepatic abscess in an immunocompetent individual.in the present case a 30-year-old african american man was admitted with fever and chills secondary to two large hepatic abscesses diagnosed on an ultrasound. the patient was started on antibiotics after blood cultures were drawn. initially the abscess was drained and showed dramatic improvement upon repeat imaging. the blood cultures revealed gram-negative rods that were identified as fusobacterium necrophorum. at that time the patient was switched to levofloxacin and metronidazole based on sen ...201323964050
lemierre's syndrome presenting with neurological and pulmonary symptoms: case report and review of the literature.lemierre's syndrome (ls) is a potentially life-threatening condition, characterized by clinical or radiologic evidence of internal jugular vein thrombosis following an oropharyngeal infection, most commonly by fusobacterium necrophorum. a high index of suspicion and early recognition is important for successful management and to prevent systemic complications like multiorgan failure with extremely high morbidity, prolonged hospitalization and, not uncommonly, death. we are reporting a rare case ...201323956578
primary lumbar epidural abscess without spondylodiscitis caused by fusobacterium necrophorum diagnosed by 16s rrna pcr.we report the case of a 71-year-old woman who presented a primary spinal epidural abscess caused by fusobacterium necrophorum. this is the second report in the medical literature to associate this organism with a primary spinal epidural abscess without spondylodiscitis. after treatment with emergency laminectomy followed by 8 weeks of antibiotic treatment the patient was cured. oral metronidazole (500 mg every 8 h) was the definitive choice of treatment. f. necrophorum spinal epidural abscess is ...201323845584
lemierre syndrome associated with 12th cranial nerve palsy--a case report and review.since the widespread availability and use of antibiotics the prevalence of lemierre syndrome (l.s.) has decreased. it is a well-described entity, consisting of postanginal septicaemia with thrombophlebitis of the internal jugular vein with metastatic infection, most commonly in the lungs. the most common causative agent is a gram-negative, non-spore-forming obligate anaerobic bacterium, fusobacterium necrophorum (f.n.). we describe the unusual clinical features of a 12-year-old boy with lemierre ...201323845534
lemierre syndrome from a neck abscess due to methicillin-resistant staphylococcus aureus.lemierre syndrome is characterized by acute septic thrombophlebitis of the internal jugular vein (ijv) that develops after an oropharyngeal infection, and can be complicated by septic emboli to lungs and other organs. the most frequent causative agent is fusobacterium necrophorum, an anaerobic bacillus found in normal oropharyngeal flora. staphylococcus aureus has emerged as a cause of lemierre syndrome in the last decade. we report a case of a 24-year-old man who developed septic ijv thrombosis ...201623797007
lemierre syndrome: study of 11 cases and literature review.lemierre syndrome is a rare but serious illness that associates throat infection and thrombosis of the internal jugular vein (ijv) or one of its tributaries with subsequent distant septic emboli. the purpose of our study was to review the pathogenesis, clinical presentation, and treatment of this disease.201423784917
characterization of fusobacterium necrophorum isolated from llama and alpaca.fusobacterium necrophorum, a gram-negative, anaerobic bacterium, is an opportunistic animal and human pathogen that causes a variety of infections termed necrobacillosis. there are 2 subspecies of f. necrophorum (subsp. necrophorum and subsp. funduliforme) that differ morphologically and biochemically and in virulence. leukotoxin, a secreted protein, is considered to be the major virulence factor. in camelids, f. necrophorum causes a variety of infections, generally involving the lips, tongue, p ...201323780933
rehabilitation and functional outcomes after extensive surgical debridement of a knee infected by fusobacterium necrophorum: a case report.joint infection is a rare but serious complication after knee injury that should be part of a physical therapist's differential diagnosis. this case report presents the care of a 17 year-old female athlete with septic arthritis from a fusobacterium infection after sustaining a right lateral meniscus tear. joint pathology combined with the aggressive infectious agent led to arthrofibrosis of her knee joint and resultant activity limitations and participation restrictions. the purpose of this case ...201323772347
outer membrane proteins of fusobacterium necrophorum subsp. necrophorum and subsp. funduliforme.fusobacterium necrophorum, classified into subsp. necrophorum (fnn) and subsp. funduliforme (fnf), is frequently associated with necrotic infections of animals and humans. the outer membrane proteins (omp) of many gram negative bacteria play an important role in bacterial adhesion and establishment of infection. the omp profile of f. necrophorum has not been well characterized. we analyzed omp of bovine strains of fnn and fnf and human strains of f. necrophorum. electrophoretic separations of ex ...201423712857
severe narrowing of left cavernous carotid artery associated with fusobacterium necrophorum infection.severe oropharyngeal infection can result in lemierre's disease, a syndrome with high mortality secondary to inflammation and thrombosis of cervical and intracranial veins with involvement of contiguous structures; however arterial involvement is rare. we report a case of lemierre's disease in a 12 year old boy with severe narrowing of the left cavernous carotid artery.201323664903
binding and activation of plasminogen at the surface of fusobacterium necrophorum.fusobacterium necrophorum is a gram-negative, anaerobic bacterium, which has been suggested to be a normal inhabitant of the oral flora. in rare cases, it can invade the tonsils and deeper tissues, causing the serious condition lemièrre's syndrome. recruitment of host plasminogen is a well-known bacterial virulence mechanism, and plasmin activity at the bacterial surface is thought to be important for bacterial invasion. herein we show that plasminogen can be recruited to the surface of f. necro ...201323583624
lemierre's syndrome: a rare case of pulmonic valve vegetation.lemierre's syndrome is an uncommon complication of pharyngitis commonly associated with an anaerobic gram negative bacterium, fusobacterium necrophorum. the syndrome usually affects young healthy adults with the mean age of 20 and is characterized by recent pharyngitis followed by ipsilateral internal jugular vein thrombosis and septic thromboembolism. the treatment is at least 6 weeks of antibiotics; the role of anticoagulation is unclear. the following presentation is a case of lemierre's synd ...201323573433
smoking promotes peritonsillar abscess.peritonsillar abscess (pta) is a frequent complication to acute tonsillitis, in particular in adolescents and young adults. smoking is most commonly initiated during adolescence and young adulthood. the study examines whether smoking increases the risk of pta and whether smoking is associated with the bacterial findings in pta. all patients with pta admitted to the ear-nose-throat department at aarhus university hospital from january 2001 through december 2006 were included in the study. age- an ...201323568043
rare but numerous serious complications of acute otitis media in a young child.acute otitis media is a very common disease in children. most children recover with symptomatic therapy like potent analgesics, but occasionally serious complications occur. we present a 3-year-old girl who suffered from acute otitis media for already 2 weeks and presented with fever, abducens nerve palsy of her left eye and vomiting. she was finally diagnosed with an acute otitis media complicated by a mastoiditis, sinus thrombosis, meningitis and cerebellar empyema. fusobacterium necrophorum w ...201323486343
uterine bacterial flora in postpartum danish holstein dairy cows determined using dna-based fingerprinting: correlation to uterine condition and calving management.the overall aim of this study was to describe uterine bacterial flora during the postpartum period in danish holstein cows using the terminal restriction fragment length polymorphism (t-rflp) method. this method produces a pattern of nucleic acid fragments from the microorganisms present, reflecting the "fingerprint" of the actual microbial flora. as well as characterizing changes in flora with time from calving and between herds, data were examined for strong relations between uterine bacterial ...201323477754
a molecular survey of a captive wallaby population for periodontopathogens and the co-incidence of fusobacterium necrophorum subspecies necrophorum with periodontal diseases.periodontal diseases (pd) are diseases of polymicrobial aetiology and constitute major health problems in captive macropods. increasing knowledge of the causal pathogens is therefore crucial for effective management and prevention of these diseases. pcr survey and sequence analyses of potential periodontopathogens in captive wallaby populations revealed a co-incidence of the diseases with the detection of fusobacterium necrophorum subsp. necrophorum (fnn) and its encoded leukotoxin (lkta) gene. ...201323428381
lemierre's syndrome: a sinister sore throat every clinician should remember.fusobacterium necrophorum is an anaerobic gram-negative bacterium that can present as a painful sore throat. although uncommon, clinicians need to be aware of this condition as this can present a diagnostic challenge, with the initial symptoms being non-specific followed by a fulminant course. we present the case of a previously healthy girl who presented with a sore throat but later developed a full-fledged picture of lemierre's disease. she developed bilateral pleural effusion and internal jug ...201323427519
early diagnosis of lemierre's syndrome based on a medical history and physical findings.a 37-year-old woman presented with fever and rigor after experiencing respiratory symptoms the previous week that had resolved within a few days. on presentation, her neck was swollen along the right sternocleidomastoid muscle, and chest ct showed pulmonary septic embolisms. lemierre's syndrome was strongly suspected based on the patient's medical history and physical findings. further examination revealed venous thrombus, and fusobacterium necrophorum was later isolated from blood cultures. ant ...201323318865
"cycliplex pcr" confirmation of fusobacterium necrophorum isolates from captive wallabies: a rapid and accurate approach.isolation and identification of obligate anaerobic bacteria is labour intensive and time consuming. this has led to the increased application of molecular tools to circumvent part of this problem. we report here the development of a rapid, accurate and cost-effective method to isolate and identify fusobacterium necrophorum species from south australian wallaby populations using a supplemented medium (bhirs) in conjunction with a "cycliplex pcr" method which involves a stepwise-selective amplific ...201323246462
microbiological profile and antimicrobial susceptibility pattern of infected root canals associated with periapical abscesses.the aim of this investigation was to identify microorganisms from root canals with periapical abscesses and assess the susceptibility of specific anaerobic bacteria to selected antimicrobials and their β-lactamase production. sixty root canals were microbiologically investigated. the susceptibility of anaerococcus prevotii, fusobacterium necrophorum, f. nucleatum, parvimonas micra, and prevotella intermedia/nigrescens to antimicrobials was evaluated with the etest, whereas β-lactamase production ...201323224675
lemierre's syndrome: diagnosis in the emergency department.a 15-year-old boy presented with signs of sepsis and a history of sore throat, fevers and shortness of breath. full examination revealed an erythematous oropharynx and mild tonsillar swelling. he rapidly deteriorated requiring admission to intensive care. blood cultures grew fusobacterium necrophorum and an ultrasound scan performed for left neck tenderness confirmed internal jugular vein thrombosis. he was diagnosed with lemierre's syndrome. this condition results from pharyngitis or tonsilliti ...201223216731
lemierre's syndrome: rare, but life threatening-a case report with streptococcus intermedius.lemierre's syndrome (ls) is a rare, but a life-threatening complication of an oropharyngeal infection. combinations of fever, pharyngitis, dysphagia, odynophagia, or oropharyngeal swelling are common presenting symptoms. infection of the lateral pharyngeal space may result in thrombosis of the internal jugular vein, subsequent metastatic complications (e.g., lung abscesses, septic arthritis), and significant morbidity and mortality. ls is usually caused by the gram-negative anaerobic bacillus fu ...201223197986
adhesion of fusobacterium necrophorum to bovine endothelial cells is mediated by outer membrane proteins.fusobacterium necrophorum, a gram-negative anaerobe, is frequently associated with suppurative and necrotic infections of animals and humans. the organism is a major bovine pathogen, and in cattle, the common fusobacterial infections are hepatic abscesses, foot rot, and necrotic laryngitis. the species comprises two subspecies: f. necrophorum subsp. necrophorum and f. necrophorum subsp. funduliforme. bacterial adhesion to the host cell surface is a critical initial step in the pathogenesis, and ...201323153522
in vitro degradation of lysine by ruminal fluid-based fermentations and by fusobacterium necrophorum.the objective of these studies was to characterize some factors affecting lysine degradation by mixed ruminal bacteria and by ruminal fusobacterium necrophorum. mixed ruminal bacteria degraded lysine, and addition of pure cultures of f. necrophorum did not increase lysine degradation. addition of acetic or propionic acid strikingly reduced nh(3) production from lysine by mixed ruminal bacteria at ph 6, but not at ph 7. although typical ruminal environments with acidic ph and normal concentration ...201323141820
fusobacterium necrophorum mastoiditis in children - emerging pathogen in an old disease.anaerobic bacteria are uncommon etiologic agents of acute mastoiditis in children. however, recent studies suggest an increase in the incidence of fusobacterium necrophorum mastoid infections in the last two decades.201323102657
lemierre syndrome.lemierre syndrome is an uncommon disease which commonly arise from acute bacterial oropharyngeal infection. this disease was first described in 1900 by courmont and cade lemierre. it is commonly caused by fusobacterium necrophorum. lemierre syndrome has been reported to be serious and potentially fatal in the preantibiotic era. it is characterized by an oropharyngeal infection leading to secondary septic thrombophlebitis of the internal jugular vein with embolization to the lungs and other organ ...201223082433
post-partum, post-sterilization tubo-ovarian abscess caused by fusobacterium necrophorum: a case report. 201223031581
ovarian venous thrombosis during septicemia due to fusobacterium necrophorum. 201223021870
neurologic manifestations of fusobacterium infections in children.fusobacterium necrophorum causes various clinical syndromes, ranging from otitis media to life-threatening lemierre's syndrome. the purpose of this study was to review our experience with pediatric fusobacterium infections. the medical records of all children aged 0 to 18 years who were diagnosed between 1999 and 2011 with fusobacterium infection were reviewed. fusobacterium was isolated from clinical samples of 27 children: blood cultures (n = 16), abscesses (n = 8), joint fluids (n = 2), and c ...201323015047
mastoiditis and gradenigo's syndrome with anaerobic bacteria. 201222978305
a cost-effectiveness analysis of identifying fusobacterium necrophorum in throat swabs followed by antibiotic treatment to reduce the incidence of lemierre's syndrome and peritonsillar abscesses.the main purpose of this paper was to estimate the cost per quality-adjusted life year (qaly) saved by identifying fusobacterium necrophorum in throat swabs followed by proper antibiotic treatment, to reduce the incidence of lemierre's syndrome and peritonsillar abscesses (pta) originating from a pharyngitis. the second purpose was to estimate the population size required to indicate that antibiotic treatment has an effect. data from publications and our laboratory were collected. monte carlo si ...201322886057
caudal vena caval thrombosis following treatment of deep digital sepsis.a diagnosis of caudal vena caval thrombosis was made by ultrasonography of a holstein cow presented for lethargy and poor milk production. medical treatment was unsuccessful and the cow was euthanized. the diagnosis was confirmed at necropsy and fusobacterium necrophorum was isolated from the thrombus. this paper discusses potential novel sources of caval thrombosis in this case.201222851781
a lemierre syndrome variant caused by klebsiella pneumoniae.lemierre syndrome is an extremely rare disease characterized by oropharyngeal infection, septicemia, internal jugular vein thrombosis, and skip lesions. the most common causative pathogen is fusobacterium necrophorum. we reported a 45-year-old woman who presented with left neck painful swelling and septicemia. magnetic resonance imaging of the head and neck demonstrated venous thrombosis extending from the left internal jugular vein to the sigmoid sinus. during admission we discovered that the p ...201222817819
acute phase response in lame cattle with interdigital dermatitis.this study was undertaken to evaluate acute phase response via assessing the concentration of serum sialic acids (total, lipid-bound and protein-bound), inflammatory mediators (ifn-γ and tnf-α) and acute phase proteins [haptoglobin (hp) and serum amyloid a (saa)] in lame cattle with interdigital dermatitis. fifteen hoof scrapings from lame cows were collected from eight commercial dairy farms. as a consequence of the difficulty in culturing and isolation, a pcr technique was used to detect the o ...201222805961
[brain abscess due to fusobacterium necrophorum in a patient with convulsion and no signs of meningitis].here, we report brain abscess due to fusobacterium necrophorum (f. necrophorum) in a 78-year-old healthy man. he developed convulsion and did not have any signs of meningitis. although the brain magnetic resonance imaging findings of the left occipital lobe were typical of a brain abscess, his cerebrospinal fluid examination revealed only slight pleocytosis and mild increase in protein levels. thus, it was difficult to rule out the possibility of metastatic brain tumor; the patient's condition w ...201222790806
fulminant fusobacterium necrophorum meningitis in an immunocompetent adolescent.fusobacterium necrophorum is an anaerobic, gram-negative highly virulent bacillus, isolated from the oropharingeal cavity, the gastrointestinal tract, and the female genital tract. it is responsible of several clinical syndromes, mainly in children or adolescents, ranging from localized abscess, usually in the upper respiratory sites, to severe septicemic diseases, including meningitis. we report the fatal case of an immunocompetent male with suppurative otitis media and meningitis. initial empi ...201222766589
[a man with a painful, swollen neck and fever].lemierre's syndrome is a rare condition mostly secondary caused by an oropharyngeal infection with fusobacterium necrophorum. we report a 62-year-old man with a classic case of lemierre's syndrome, most likely caused by a diminished immunity as a result of an underlying chronic lymphatic leukemia.201222742440
a case of lemierre's syndrome in association with liver abscess without any other metastatic lesions.lemierre's syndrome (ls) is characterized by pharyngitis followed by septicemia, internal jugular vein thrombophlebitis, and metastatic embolization in general. ls is commonly caused by fusobacterium necrophorum. herein, we present a case of ls with liver abscesses that presented as a sole metastatic lesion. we were not able to diagnose ls until fusobacterium necrophorum was isolated due to the lack of the common involvement. doripenem was effective against the pathologic features including the ...201222687854
[lemierre's syndrome following peritonsillar abscess].lemierre's syndrome is a rare but serious condition, characterized by disseminated infection with fusobacterium necrophorum, most often originating from the oropharynx. thrombophlebitis of the internal jugular vein and septic embolisms to various organs is the typical clinical picture. we describe a 16-year-old man with peritonsillar abscess who developed abscesses in lungs, liver and spleen. the patient was admitted to the icu and treated with surgical drainage of infectious foci, antibiotics a ...201222668650
[lemierre's syndrome as differential diagnosis of lung cancer].lemierre's syndrome is a disseminated infection which is usually caused by fusobacterium necrophorum. an oropharyngeal infection progresses to a septic thrombophlebitis of the internal jugular vein and later metastatic infections throughout the body occur. we present a clinical case in which a patient, initially presenting with symptoms characteristic of pulmonary cancer, turned out to have a rare variant of lemierre's syndrome caused by fusobacterium nucleatum.201222668649
lemierre's syndrome due to fusobacterium necrophorum.we present a case of a patient with lemierre's syndrome caused by fusobacterium necrophorum who developed a right frontal lobe brain abscess. we summarise the epidemiology, microbiology, pathogenesis, clinical presentation, diagnosis, complications, therapy, and outcomes of lemierre's syndrome. f necrophorum is most commonly associated with lemierre's syndrome: a septic thrombophlebitis of the internal jugular vein. patients usually present with an exudative tonsillitis, sore throat, dysphagia, ...201222633566
lemierre syndrome.lemierre's syndrome is an uncommon complication of pharyngitis in the united states and caused most commonly by the bacterium fusobacterium necrophorum. the syndrome is characterized by a history of recent pharyngitis followed by ipsilateral internal jugular vein thrombosis and metastatic pulmonary abscesses and is a disease for which patients will seek medical care and advice. as most patients are admitted to the hospital under internal medicine, practitioners should be familiar with the usual ...201222561543
lemierre's syndrome due to klebsiella pneumoniae in a 63-year-old man with diabetes: a case report.lemierre's syndrome was originally documented to be caused by fusobacterium necrophorum. it is a very rare condition with a prevalence of one to 14.4 instances per million. its presentation is varied, not only in composition but also in the infecting organism. treatment with anticoagulants has been controversial and applied only on a case-by-case basis.201222472458
[lemierre syndrome: thrombosis of the cavernous sinus and internal carotid artery occlusion secondary to acute sphenoid sinusitis].lemierre syndrome (ls) typically consists of a septic thrombophlebitis of the internal jugular vein caused by fusobacterium necrophorum. we present an unusual variant of ls with cavernous sinus thrombosis and occlusion of the ipsilateral internal carotid artery secondary to sphenoid sinusitis caused by streptococcus viridans.201322424548
[treatment of peritonsillar abscess].peritonsillar abscess (pta) is associated with high morbidity and can cause serious and life-threatening complications. in denmark, the most commonly isolated bacteria are fusobacterium necrophorum and streptococcus pyogenes gr. a. the incidence of pta in denmark is 41/100,000/year, the highest incidence ever reported for pta. there is no definite consensus on the treatment. we recommend most patients treated with puncture and antibiotics as outpatients, and if necessary acute tonsillectomy inst ...201222310005
[fusobacterium necrophorum is a research field with a distinct danish imprint]. 201222293070
fusobacterium necrophorum--beyond lemierres syndrome.fusobacterium necrophorum is a non-sporulating anaerobic gram negative bacillus and has traditionally been associated with lemierre's syndrome. the authors report a 34-year-old male who presented to the emergency department with a week's history of dull epigastirc pain. significant medical history included chronic pancreatitis secondary to alcohol use. the patient had radiological evidence of acute on chronic pancreatitis with thrombosis of the portal vein and multiple intrahepatic abscesses. ct ...201122674593
bilateral lemierre syndrome secondary to periodontitis: a case report and review of the literature.lemierre syndrome is the typical presentation of human necrobacillosis. it is characterized by an initial infection, progressing to septic thrombophlebitis, septicemia, and multisystem embolic necrotic abscesses. it is usually caused by fusobacterium necrophorum, but its pathophysiology remains obscure. a case of bilateral lemierre syndrome secondary to periodontitis is reported.200923168512
presence of bacteria in the endometrium and placentomes of pregnant cows.bacterial invasion of the bovine uterus during the postpartum period occurs in most cows, but the general consensus is that these bacteria are eliminated before the next pregnancy. the pregnant uterus has therefore hitherto been considered a sterile environment, but this assumption has now been challenged by recent studies in humans, which indicate that bacteria can be present in the placenta of term pregnancies without causing abortion. the aim of the present study was therefore to investigate ...201728708498
prevalence of fusobacterium necrophorum and other upper respiratory tract pathogens isolated from throat swabs.fusobacterium necrophorum, an anaerobic, gram-negative rod, has been identified recently as a significant cause of persistent sore throat syndrome (psts). this disease is characterised by chronic, recurrent or persistent sore throat, which is believed to respond poorly to penicillin in vivo. the aim of this study is to examine the prevalence of f. necrophorum in all throat swabs received in our diagnostic microbiology department and to compare the results with those for other recognised respirat ...200528705126
blood as a route of transmission of uterine pathogens from the gut to the uterus in cows.metritis is an inflammatory disease of the uterus caused by bacterial infection, particularly bacteroides, porphyromonas, and fusobacterium. bacteria from the environment, feces, or vagina are believed to be the only sources of uterine contamination. blood seeps into the uterus after calving; therefore, we hypothesized that blood could also be a seeding source of uterine bacteria. herein, we compared bacterial communities from blood, feces, and uterine samples from the same cows at 0 and 2 days ...201728841911
mathematical modeling of ovine footrot in the uk: the effect of dichelobacter nodosus and fusobacterium necrophorum on the disease dynamics.dichelobacter nodosus is a virulent, invasive, anaerobic bacterium that is believed to be the causative agent of ovine footrot, an infectious bacterial disease of sheep that causes lameness. another anaerobe, fusobacterium necrophorum, has been intimately linked with the disease occurrence and severity. here we examine data from a longitudinal study of footrot on one uk farm, including quantitative pcr (qpcr) estimates of bacterial load of d. nodosus and f. necrophorum. the data is at foot level ...201728461081
bacteraemia and liver abscess due to fusobacterium necrophorum.fusobacterium necrophorum is the oropharyngeal pathogen usually associated with lemierre's syndrome, a pharyngeal infection which evolves to sepsis, septic emboli and thrombophlebitis of the adjacent neck vessels. it is an uncommon causative bacteria of a liver abscess, and an extensive workup should, therefore, be performed in order to rule out potential sources of the infection. this case report describes the workup that led to the diagnosis of a colorectal carcinoma, which was deemed to be th ...201728754755
pulmonary empyema caused by co-infections of mycoplasma pneumoniae and fusobacterium necrophorum: a rare case of lemierre syndrome. 201728698043
fissuration of vertebral artery mycotic aneurysm due to lemierre syndrome. 201728652095
the long shadow of lemierre's syndrome.lemierre's syndrome is a rare and feared complication of pharyngitis, occurring most commonly in adolescents and young adults. it is typically defined by the constellation of septic internal jugular vein thrombophlebitis, pulmonary and other septic emboli, and sterilesite infection by fusobacterium necrophorum. the rarity and severity of lemierre's syndrome has made it an attractive subject for case reports but there is a paucity of evidence to inform areas of persistent uncertainty. in recent y ...201728646962
septic thrombophlebitis of the internal jugular vein, a case of lemierre's syndrome.an 18-year-old gentleman with a history of recurrent tonsillitis presented to the emergency room complaining of worsening sore throat. he was found to have a peritonisillar abscess, and imaging revealed a non-occlusive left internal jugular vein thrombosis. lemierre's syndrome is a rare, potentially fatal condition characterized by internal jugular vein thrombosis with septicemia following an acute oropharyngeal infection. while anticoagulation is the mainstay of treatment of deep venous thrombo ...201728580216
pathogenesis and treatment of bovine foot rot.bovine foot rot (bfr) is an infectious disease of the interdigital skin and subcutaneous tissues of beef and dairy cattle that occurs under a variety of management and environmental settings. the anaerobic, gram-negative bacteria fusobacterium necrophorum, porphyromonas levii, and prevotella intermedia are commonly isolated from lesions. a multitude of host, agent, and environmental factors contribute to the development of bfr. initiation of systemic antimicrobial therapy early in the course of ...201728579042
mixed species biofilms of fusobacterium necrophorum and porphyromonas levii impair the oxidative response of bovine neutrophils in vitro.biofilms composed of anaerobic bacteria can result in persistent infections and chronic inflammation. host immune cells have difficulties clearing biofilm-related infections and this can result in tissue damage. neutrophils are a vital component of the innate immune system and help clear biofilms. the comparative neutrophilic response to biofilms versus planktonic bacteria remains incompletely understood, particularly in the context of mixed infections. the objective of this study was to generat ...201728526497
a six-month audit of the isolation of fusobacterium necrophorum from patients with sore throat in a district general hospital.fusobacterium necrophorum is an obligate anaerobe believed to be a member of the normal flora of the human oropharangeal and urogenital tract. it has been associated with deep-seated infections and was first described in 1936 by lemierre, a french microbiologist. there is now strong evidence to suggest that it is also a cause of recurrent sore throat and persistent sore throat syndrome (psts) without leading to full systemic infection. it is considered to be the second most common cause of sore ...200728696888
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