| swine influenza virus vaccine: potentiation of antibody responses in rhesus monkeys. | polyriboinosinic-polyribocytidylic acid stabilized with poly-l-lysine and carboxymethylcellulose [poly(iclc)] enhances the antibody response in rhesus monkeys immunized with swine influenza virus subunit vaccine. monkeys given the vaccine-adjuvant combination had earlier and significantly (p less than .05) higher titers by 14 days compared to those that received vaccine alone. the potentiation of the antibody response of young monkeys given a split-virus vaccine in combination with poly(iclc) su ... | 1977 | 408923 |
| visual input to the visuomotor mechanisms of the monkey's parietal lobe. | a newly identified class of neurons of the parietal cortex, studied in waking monkeys (macaca mulatta), is activated by visual stimuli, perhaps via the retino-collicular visual pathway. this afferent input is thought to provide the visual cues activating the visuomotor mechanisms of the parietal lobe for the direction of visual attention. | 1977 | 408924 |
| comparative distribution and embryotoxicity of acetylsalicylic acid in pregnant rats and rhesus monkeys. | | 1977 | 408942 |
| [comparative characteristics of corticosteroid metabolism in lower simians and man]. | corticosteroid metabolism has been investigated in macaca mulatta, papio hamadryas, cercopithecus aethiops, erithrocebus patas and man. similar character of corticosteroid metabolism in monkeys and man was found. significant interspecific differences with respect to quatitative and qualitative parameters of the metabolism of steroid hormones were found. in this respect m. mulatta and p. hamadryas are most similar to man as compared with other monkeys. these two species may be used as an adequate ... | 1977 | 409003 |
| relationship between catecholamines and the periodicity of spontaneous uterine activity in a nonpregnant primate (macaca mulatta). | rhesus monkeys weighing 6-8 kg and demonstrating regular menstrual cycles were used to delineate the relationships between the circadian patterns in spontaneous uterine activity, the urinary excretion of 2 catecholamines, norepinephrine and epinephrine, and the alterations in adrenergic neuroreceptors. in experiment 1 norepinephrine and epinephrine concentrations were determined by the zuspan and cooley method. these values were correlated with the circadian patterns of spontaneous uterine ac ... | 1977 | 409290 |
| the effect of photocoagulation on the choroidal vasculature and retinal oxygen tension. | light microscopy and latex-pigment injection of rhesus monkey eyes studied at varying times after retinal laser and xenon photocoagulation of varying intensity showed that the choriocapillaris was obliterated by a wide range of intensities but that the choroidal arteries and veins remained open. retinal oxygen tensions acutely increased over the lesion but later subsided to normal. multiple treatment sessions several days apart may reduce the risk of hemorrhage associated with hypermia secondary ... | 1977 | 409296 |
| the effect of systolic hypertension on rhesus monkey eyes after ocular sympathectomy. | systolic hypertension was induced in rhesus monkeys by obstructing the thoracic aorta and by ocular sympathectomy obtained with the retrobulbar injection of 6-hydroxydopamine. during the late phase of fluorescein angiography, fluorescein leaked from the choroidal circulation into the retina. the retinal vessels did not leak fluorescein. the effect was not permanent since fluorescein did not leak into the retina after the blood pressure returned to normal. | 1977 | 409298 |
| an electron microscope study of the perfusion-fixed spleen. ii. fine structure of the sinus lining cells with respect to filamentous structures in monkey spleens. | in the perfusion-fixed spleen of monkey (macaca mulatta) were studied with the electron microscope the cytoplasmatic structures of the sinus lining cells. the particular interest find the contractile filaments in this cells, which are important for the cell contraction. the connections to the smooth endoplasmatic reticulum are very strong as in the muscle fiber or muscle cell. | 1977 | 409310 |
| sperm/egg interaction: the specificity of human spermatozoa. | human spermatozoa display unusually limited affinities in their interaction with oocytes of other species. they adhered to and, when capacitated, penetrated the vestments of the oocyte of an ape--the gibbon, hylobates lar--both in vivo and in vitro. on the other hand, human spermatozoa would not even attach to the zona surface of sub-hominoid primate (baboon, rhesus monkey, squirrel monkey), nor to the non-primate eutherian oocytes tested. among the apes the gibbon stands furthest from man. thus ... | 1977 | 409311 |
| [comparison of the field formation in the frontal area during prenatal period in macaca (macacus rhesus, s. macaca mulatta) and man]. | a developmental comparison of the fields 8, 9, 10, 11, 12, 47 during prenatal life in macacus rhesus and man was performed. cytomyeloarchitectonic and morphometric methods of investigation were applied: the areas of the fields in question, the transverse thickness of the cortex, separate cortical layers, neuronal dimentions were measured. alongside, general regularities in the development of these fields in both species (the frontal cortex is laid earlier than other parts of the cortex, the term ... | 1977 | 409377 |
| optic disc edema in raised intracranial pressure. vi. associated visual disturbances and their pathogenesis. | the pattern and pathogenesis of nonlocalizing visual disturbances, associated with optic disc edema (ode). raised cerebrospinal fluid pressure, and intracranial space-taking lesions were investigated experimentally in rhesus monkeys with simulated progressive brain tumor and clinically in patients with benign intracranial hypertension. the visual disturbances occurring in one of both eyes were of three types: recurrent attacks of transient obscuration, permanent blindness, and various types of v ... | 1977 | 409382 |
| cardiopulmonary vagal afferents in the monkey: a survey of receptor activity. | a survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the rhesus monkey. recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. a total of 425 receptors were identified in sixteen animals. these consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricula ... | 1977 | 409390 |
| effect of toloxatone on behaviour of primates. | 1. the effects of (3-methyl)-3-phenyl-5-hydroxy-methyl-2-oxazolidinone (toloxatone) were studied on the behaviour of three species of primates: baboon, rhesus monkeys and chimpanzee. 2. the activity against reserpine-induced depression is observed in baboon as in rodents. 2. the administration of toloxatone induces three effects which probably have the same origin: suppression of feeding inhibition of the subordinate baboon, improvement of escape reaction in the conditioned chimpanzee, increase ... | 1977 | 409416 |
| the animal pharmacology of buprenorphine, an oripavine analgesic agent. | 1. the general pharmacology of buprenorphine, a potent analgesic agent derived from oripavine, is described. 2. after cute administration of buprenorphine, the spontaneous locomotor activity of mice was increased; rats displayed stereotyped licking and biting movements; behavioural depression was marked in guinea-pigs but mild in rhesus monkeys. the behaviour of cats was unchanged. 3. in general, buprenorphine reduced heart rate but had no significant effect on arterial blood pressure in conscio ... | 1977 | 409449 |
| an experimental study of the efferent connections of the superior cerebellar peduncle in the rhesus monkey. | unilateral electrolytic lesions were made in the right superior cerebellar peduncle immediately lateral of its decussation or in the dentate nucleus of 6 monkeys. the course of the contralateral ascending and descending degenerated fibers and sites of preterminal degenerated fibers were studied in material stained by fink-heimer, nissl and weil methods. major thalamic sites of preterminal degeneration were in the rostral part of vplo, and in vpi, vlo, vapc, cl and pcn. in other thalamic nuclei o ... | 1977 | 409452 |
| estrogen inhibition of basal and gonadotropin-stimulated progesterone production by rhesus monkey luteal cells in vitro. | | 1977 | 409599 |
| estrogen-induced gonadotropin surges in decerebrated female rhesus monkeys with medial basal hypothalamic peninsulae. | hypothalamic peninsulae, posteriorly continuous with the brain stem, were produced in ovariectomized rhesus monkeys by aspiration of the cerebral hemispheres and all brain structures anterior and dorsal to the optic chiasm. these preparations were sustained for 52 to 60 h postoperatively by maintaining blood gases and ph within physiological limits and by supporting arterial blood pressure, when necessary, with infusions of rhesus monkey blood and norepinephrine. the sc injection of estradiol be ... | 1977 | 409600 |
| biosynthesis of the blood-group-b-specific trisaccharide in a rhesus monkey. | a rhesus monkey, serologically grouped as b, has been shown to excrete low-molecular-weight carbohydrate material in urine closely related to that found in human urine. galactose feeding resulted in the excretion of a trisaccharide which was shown to be identical to the trisaccharide isolated from the urine of group b humans under the same conditions. experiments in which [14c]galactose was administered both orally and via an intestinal vein demonstrated that the intestine is the site of biosynt ... | 1977 | 409603 |
| salutary effects of early experience on deficits caused by lesions of frontal association cortex in developing rhesus monkeys. | | 1977 | 409614 |
| anovulatory menstrual cycles in the rhesus monkey: the significance of serum follicle-stimulating hormone/luteinizing hormone ratios. | | 1977 | 409623 |
| virulence and immunogenicity of a temperature-sensitive dengue-2 virus in lower primates. | clones of dengue-2 virus were tested for virulence by inoculation of rhesus monkeys and chimpanzees. although primates showed no overt signs of illness, inoculation with the parent virus or a subline of a large-plaque clone resulted in a viremia lasting 1 to 7 days. by these criteria, sublines of a small-plaque clone were significantly less virulent and produced little or no viremia in primate hosts. although they had a substantially reduced viremia, primates inoculated with the small-plaque sub ... | 1977 | 409682 |
| biologic and antigenic characteristics of epstein-barr virus-related herpesviruses of chimpanzees and baboons. | leukocyte-transforming agents were isolated in baboon leukocytes inoculated with oral excretions from immunosuppressed chimpanzees. the transformed lymphoblasts had b cell surface markers and harbored herpes-type virus particles; 5-10% of the cells contained cytoplasmic antigens reactive with epstein-barr virus (ebv)-antibody-positive chimpanzee, human and baboon sera. these sera also neutralized the transforming activity of the chimpanzee virus. long-term lymphoid cell lines were established fr ... | 1977 | 409690 |
| reflection of light by small areas of the ocular fundus. | light reflected from 50 micrometer spots on the fundi of two rhesus monkeys and three human volunteers was measured as a function of wavelength in 10 nm. jumps from 400 to 900 nm. the areas measured were a retinal artery and vein, areas of the disk, macula, and retina devoid of visible blood vessels, and the fovea. | 1977 | 409694 |
| genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons. | | 1977 | 409739 |
| immunization with shigella dysenteriae type 1: evaluation of antitoxic immunity in prevention of experimental disease in rhesus monkeys (macaca mulatta). | the role of serum antitoxic antibody in protection against the dysentery caused by shigella dysenteriae type 1 (shiga's bacillus) was studied in monkeys fed 10(10) virulent organisms after parenteral immunization with a formalin-inactivated shiga toxoid preparation standardized in mice. two 125-microgram doses of toxoid adsorbed on aluminum hydroxide adjuvant and given 14 days apart provided mice with a 54-fold increase in resistance to parenteral toxin. in rhesus monkeys (macaca mulatta), the s ... | 1977 | 409782 |
| transoral, transsphenoidal microsurgical exposure of the pituitary gland and infundibulum in the rhesus monkey. description of operative technique. | a transoral, transsphenoidal microsurgical technique for exposing the pituitary stalk and gland of the rhesus monkey is described and illustrated. the technique has proved to be a safe and practical method for performing a variety of pituitary operations in a total of 37 animals. the procedures have included complete hypophysectomy, posterior lobe resection, pituitary stalk section, collection of portal venous blood, collection of pituitary venous blood, and placement of lessions in the organum ... | 1977 | 409810 |
| ketamine self-administration by the rhesus monkey. | intravenously administered ketamine served as a reinforcer of self-administration behavior in rhesus monkeys during daily 2-hour sessions. when the dose of ketamine was varied over a wide range at fixed-ratio schedules of reinforcement of 1, 8 and 64, the response rate was an inverted u-shaped function of the dose. maximal response rates occurred at progressively higher doses as the fixed-ratio size was increased; drug intake per session was positively related to the dose. when the ketamine dose ... | 1977 | 409837 |
| quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after-nystagmus. | 1. velocity characteristics of optokinetic nystagmus (okn) and optokinetic after-nystagmus (okan) induced by constant velocity full field rotation were studied in rhesus monkeys. a technique is described for estimating the dominant time constant of slow phase velocity curves and of monotonically changing data. time constants obtained by this technique were used in formulating a model of the mechanism responsible for producing okn and okan.2. slow phase velocity of optokinetic nystagmus in respon ... | 1977 | 409838 |
| synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials. | a series of 2-benzyloxy and 2-benzylthio analogues of primaquine has been synthesized and evaluated against plasmodium berghei in the mouse and plasmodium cynomolgi in the rhesus monkey. 8-aminoquinoline toxicity, as measured in the rane mouse screen, was reduced, and these compounds showed significant blood schizonticidal antimalarial activity in mice. in monkeys, significant tissue-schizonticidal activity was observed. | 1977 | 409843 |
| myocardial fibrosarcoma in rhesus monkey. | | 1977 | 409880 |
| chronic effects of acetylmethadol and methadone in rhesus monkeys. | | 1977 | 409895 |
| leukocytes are consistently associated with degenerating embryos in iud-bearing rhesus monkeys. | | 1977 | 409954 |
| [enterohepatic circulation of bile acids and biliary lipid secretion]. | the enterohepatic circulation of bile acids in man is reviewed. the chemistry of biliary bile acids is summarized and related to the formation of primary bile acids in the liver and secondary bile acids in the intestinal lumen. new findings showing that lithocholic acid is absorbed in man are presented, and the recent experiments showing that lithocholic acid is extensively sulfated are reviewed. the consistent hepatotoxicity of chenodeoxycholic acid in the rhesus monkey, which contrasts with it ... | 1977 | 409965 |
| protein deprivation in primates: xii. food preferences of juvenile rhesus monkeys. | 21 male and 18 female juvenile rhesus monkeys whose mothers' prenatal diets varied according to protein content (either 1-, 2-, or 4-gm protein/kg body weight/day) were given a food-preference task. 20 monkeys were between 3 and 4 yr. old; 19 were between 1 1/2 and 2 1/2 yr. old. for each trial small pieces of the same type food were placed in 8 equally spaced wells about the circumference of a circular tray held outside each monkey's cage. responsiveness to the 21 natural foods (assorted cheese ... | 1977 | 409989 |
| effects of pgf2alpha and pgf2alpha, 1-15 lactone on the corpus luteum and on early pregnancy in the rhesus monkey. | the effects of prostaglandin (pg)f2alpha and pgf2alpha, 1-15 lactone were compared in luteal phase, non-pregnant and in early pregnant rhesus monkeys. animals treated with either pg after pretreatment with human chorionic gonadotropin (hcg) had peripheral plasma progesterone concentrations that were not statistically different from those in animals treated with hcg and vehicle. however, menstrual cycle lengths in monkeys treated with pgf2alpha, 1-15 lactone were significantly (p less than 0.02) ... | 1977 | 410075 |
| hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. | the subiculum of the primate hippocampal formation stands at the end of a polarized sequence of intrinsic hippocampal efferents and is the source of efferents to the medial frontal cortex, the caudal cingulate gyrus, and the parahippocampal area and amygdala in the temporal lobe. in addition, the subiculum sends subcortical efferents to the septum and diencephalon. | 1977 | 410102 |
| premotor cortical ablations in monkeys: contralateral changes in visually guided reaching behavior. | in rhesus monkeys (macaca mulatta), ablation of the premotor and supplementary motor areas and the adjoining rostral half of the precentral gyrus impairs the capacity of the contralateral arm to reach around a transparent obstacle to a visible food reward, and results in a tendency of this arm to reach around a transparent obstacle to a visible food reward, and results in a tendency of this arm to reach straight to where the food is visible. this may reflect a disinhibition of brainstem pathways ... | 1977 | 410103 |
| biological spectrum of two spirolactone derivatives with some observations on anti-fertility activity. | bioassays were conducted to determine various endocrinological properties of two spirolactone derivatives, 4',5'-dihydrospiro-[estr-4-ene-17,2'(3'h)-furan]-3-one (compound i) and dispiro[cyclopropane-1,6'-estr-4'-ene-17',2"(3"h)-furan]-3'-one (compound ii). they proved to be very potent estrogen antagonists in immature mice and castrate ewes and neither exhibited inherent estrogenicity. they were moderately active as progestins and gonadotropin inhibitors. compound ii possessed slight androgenic ... | 1977 | 410120 |
| effects of antihypertensive drugs on blood velocity in rhesus monkeys. | increasing evidence suggests that higher blood velocity, by causing turbulence and high shear rates at the endothelial surfaces of arteries, may be important in the pathogenesis of atherosclerosis. in order to measure the effects of antihypertensive agents on blood velocity, an improved method has been developed for analysis of doppler ultrasound velocity recordings. the audio signal from a doppler velocity meter is subjected to spectral analysis; the sonagraph thus obtained is digitized with th ... | 1977 | 410122 |
| [influence of a complex of poly(i). poly(c) and poly-l-lysine on the course of vaccinia in monkeys]. | experiments of 22 macaca rhesus monkeys were carried out to study the interferon-inducing and antiviral activity of poly(i) - poly(c) and of its complex with poly-l-lysine. the complexed double-stranded polyribonucleotide induced active production of serum interferon and markedly protected the monkeys inoculated intradermally with vaccinia virus (10 monkey id50 by intradermal inoculation). the effectiveness of the protective effect depended on the schedule and routes of administration of the pre ... | 1977 | 410162 |
| systemic and regional blood flow during epidural anesthesia with epinephrine in the rhesus monkey. | hemodynamic and regional blood flow measurements were made in five rhesus monkeys before and 10, 20, 40 and 80 min after induction of high epidural anesthesia (t1) with lidocaine (1%) containing 1:200,000 epinephrine. following induction of epidural anesthesia with epinephrine, there were significant decreases in heart rate, mean arterial pressure, cardiac output and myocardial and renal blood flow. the percentage of cardiac output received by the brain was significanly increased following epidu ... | 1977 | 410229 |
| complement depletion following envenomation by russell's viper and echis carinatus (saw-scaled viper) in the rhesus monkey. | significant depletion of c3 was observed following administration of lethal and sublethal doses of russell's viper and echis carinatus venom to rhesus monkeys. a sequential study carried out over a period of 3 weeks following sublethal envenomation showed a steady rise in the c3 level from 48 hours onwards. by the 20th day the c3 values had attained the pre-envenomation levels. the extent of depletion of c3 was similar in both russell's viper and e. carinatus envenomation. because of the close i ... | 1977 | 410316 |
| quantitative aspects of pyrimethamine-sulfonamide synergism. | the experiments described in this report have dealt with the dimensions of therapeutic potentiation achieved when combinations of pyrimethamine and sulfadiazine were administered to rhesus monkeys infected with a drug-susceptible strain of plasmodium cynomolgi or its pyrimethamine-resistant variant and to owl monkeys infected with strains of p. falciparum and p. vivax of varying degrees of resistance to this pyrimidine. these evaluations showed: 1) that when delivered in combination, the activit ... | 1977 | 410317 |
| the activity of a benzothiopyranoindazole (ia-4 n-oxide) against schistosoma mansoni infection in rhesus monkeys. | the prophylactic and therapeutic efficacies of ia-4 n-oxide against schistosoma mansoni in rhesus monkeys (macaca mulatta) have been evaluated. ten monkeys were divided into 5 groups of 2 monkeys each. all monkeys were exposed to s. mansoni cercariae on day 0 and treatment groups were established as follows: untreated controls, oral prophylactic administration, intramuscular prophylactic administration, oral therapeutic administration, and intramuscular therapeutic administration. analysis of pa ... | 1977 | 410318 |
| methyl alcohol poisoning iii. ocular toxicity. | the ocular toxicity of methyl alcohol has been investigated in six rhesus monkeys. all the animals developed fundus changes within 43 to 171 hours after its ingestion. the only fundus lesion seen was optic disc edema and associated changes, usually of a marked degree. fluorescein fundus angiography confirmed the findings. the retinal and choroidal circulations, including the retinal capillary bed, were normal. ophthalmoscopically and angiographically, optic disc edema in methyl alcohol poisoning ... | 1977 | 410394 |
| radioimmunoassay of parathyroid hormone (parathyrin) in monkey and man. | a radioimmunoassay for rhesus monkey and human immunoreactive parathyrin was developed in which a selected anti-bovine parathyrin antiserum, radioiodinated purified bovine parathyrin tracer, and human parathyroid tissue-culture media standards were used. the resulting data indicate that (a) the method is sensitive, specific, accurate and reproducible; (b) it is valid for both the rhesus monkey and the human; (c) the serum immunoreactive parathyrin concentration of the monkey is essentially the s ... | 1977 | 410564 |
| endocrine function in female rhesus monkeys after hypothalamic disconnection. | | 1977 | 410633 |
| organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey. | in 25 rhesus monkeys horseradish peroxidase was injected in different parts of the frontal cortex. the retrogradely labelled thalamic neurons formed longitudinal bands, some of which crossed the internal medullary lamina, and extended from one thalamic nucleus into another. on the basis of these findings the frontal cortex was subdivided into seven transverse cortical strips which receive afferents from seven longitudinal bands of thalamic neurons. the most rostral transverse strip receives affe ... | 1977 | 410652 |
| the shift-effect in the lateral geniculate body of the rhesus monkey. | responses to sudden shifts of a pattern far away from the receptive field (shift-effect) were found in 73 out of 81 cells of the ventral, magnocellular lgn layers, but in only 26 out of 85 cells of the dorsal, parvocellular layers. most of the former responses were clear and excitatory, and most of the latter were weak and inhibitory. excitatory responses were stronger for steady receptive field illumination which when turned on also yielded an excitation. no convincing dependence on the colou ... | 1977 | 410653 |
| response plasticity of neurons in auditory cortex of the rhesus monkey. | auditory-evoked responses in single neurons from rhesus monkey auditory cortex were measured under four relatively well defined behavioral and physiological conditions: (1) monkey awake and performing a simple auditory reaction time task; (2) monkey awake but not performing a task (stage a); (3) monkey in a drowsy or stage 1 sleep state (state b); and (4) monkey anesthetized with a short-acting nonbarbiturate anesthetic. for most units studied the response evoked by the auditory stimulus was gre ... | 1977 | 410654 |
| the effects of danazol on the pituitary-ovarian axis in the rhesus monkey (macaca mulatta). | | 1977 | 410687 |
| effects of maternal mobility, partner, and endocrine state on social responsiveness of adolescent rhesus monkeys. | the social behavior of rhesus monkeys raised for the 1st year of life with mobile (ms) or stationary (ss) cloth surrogate mothers was investigated when the animals reached 4-5 yr of age. the ms males generally refrained from social interaction during initial pairings with females, whereas ss males interacted frequently, but were more often the targets of attacks and chases from adult females than were ms males. the ms males were more likely to vary their social behavior according to the behavior ... | 1977 | 410688 |
| effects of geographic transfer on the timing of seasonal breeding of rhesus monkeys. | this is a study of the effects of geographic transfer on the timing of seasonal breeding of free-living rhesus monkeys on cayo santiago and la parguera islands in puerto rico. the results demonstrated a progressive shift in the breeding season of the transferred group. the full shift required a period of 2 years. change from one environment to another produced shifts in onset of estrous. the explanation for this phenomenon proposes an interaction between the specific reproductive state of the fe ... | 1977 | 410708 |
| uveoscleral aqueous outflow in the rhesus monkey: importance of uveal reabsorption. | the uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of ringer's solution containing both fluorescein and 125i albumin. at 20 mm. hg, an excess of fluorescein equivalent in amount to 0.45 microliter/min. of anterior chamber perfusate and an excess of 125i albumin equivalent to 0.18 microliter/min. of perfusate was found in the vortex vein blood compared to systemic blood. at 32 ... | 1977 | 410750 |
| vitreal syneresis in rhesus monkeys. | the eyes of 15 rhesus monkeys were evaluated. various degrees of vitreal syneresis were observed in 28 of the 30 eyes. the observed vitreal structures varied from fine strands randomly spaced throughout the vitreous to thick, intertwining, fibrous networks with some clumping of the collagenous condensate at the fiber junctions. qualitatively, the degree of syneresis was slightly more extensive in the eight older mature males than in the seven younger animals. in all animals a clear view of the f ... | 1977 | 410752 |
| systemic versus intraovarian progesterone replacement after luteectomy in rhesus monkeys: differential patterns of gonadotropins and follicle growth. | similar to luteectomy (clx) alone, systemic replacement of progesterone (p) to maintain circulating midluteal phase levels after clx, and p withdrawal 10-11 days later were not accompanied by changes in serum fsh or lh levels. the next preovulatory gonadotropin surges, however, were delayed by about 10 days, relative to clx alone. in contrast, a marked rise in serum fsh was observed after unilateral introvarian p replacement at clx, even though accompanying patterns of serum estradiol (e2) and p ... | 1977 | 410825 |
| prevalence of haemolytic streptococcal infection in rhesus monkeys. | seventy-six monkeys arriving in 10 batches were investigated within a day or two of their arrival for beta-haemolytic streptococcal infections. 10.53 per cent of monkeys yielded group a beta haemolytic streptococcus. majority of the isolates were t pattern i. with aso test, 44.7 per cent monkeys had low titres while with a-dnase 'b' 'test, 64.5 per cent of the monkeys had low titres. | 1977 | 410875 |
| sources of error in measuring cerebrospinal fluid formation by ventriculocisternal perfusion. | ventriculocisternal perfusion is regarded as a precise method of measuring the rate of formation of cerebrospinal fluid (csf) but it possesses inherent potential sources of error. using the technique to measure csf formation rate in the rhesus monkey, we have observed rate changes when none were expected. most puzzling has been the steady decline of csf formation rate at 4 percent each hour during the final five hours of a seven hour perfusion although variables known to affect csf formation rem ... | 1977 | 410910 |
| abnormal morphology of the fetal monkey (macaca mulatta) thymus exposed to a corticosteroid. | | 1977 | 410938 |
| effects of greater superficial petrosal neurectomy on nasal mucosa in rhesus monkeys (macaca mulatta). | the effects of greater superficial petrosal neurectomy on normal nasal mucosa was studied in ten rhesus monkeys by light microscopy at four, six, and eight weeks postoperatively. greater superficial petrosal neurectomy caused no histological alteration in the nasal mucosa of these monkeys. these procedures were accomplished with no complications. | 1977 | 410999 |
| long-term results after intentional tooth reimplantation in monkeys. | the purpose of this study was to evaluate histologically the long-term response to intentional tooth reimplantation in six rhesus monkeys. the study revealed that cervical and apical root resorption is a universal complication after tooth reimplantation and that arrested areas of resorption will show repair by deposition of cementum. a highly cellular periodontal membrane usually will develop. periodontal fibers will reattach to reparative bone and cementum but seldom regain functional orientati ... | 1977 | 411079 |
| experimental brugia malayi infections in the rhesus monkey. | twenty-eight rhesus monkeys in 3 groups were exposed to single (group i), double (group ii), and multiple (group iii) inoculations with b. malayi infective larvae. infections were monitored by microfilarial and blood counts, selected biochemical tests, ifa responses, and records of body temperature and lymphadenopathy before and/or after treatment with dec. as a whole, the highest microfilaraemia levels were observed in group ii and lowest in group iii monkeys. eosinophilia was a common occurren ... | 1977 | 411182 |
| some effects of bunnell suture on otherwise uninjured tendons in subhuman primates. | an experimental study was performed in rhesus monkeys (m. mulatta) to examine the contribution of bunnell tendon suture to the production of postoperative tendon adhesions. it was found that bunnell suture used with atraumatic technique caused a significant depression of in vitro tendon surface plasminogen activator activity, allowing the in vivo persistence and fibrous organization of fibrinous postoperative adhesions to sutured areas. bunnell suture also produced coagulation necrosis of the su ... | 1977 | 411189 |
| chronic toxicity of 2,5,4'-trichlorobiphenyl in young rhesus monkeys. i. body distribution, elimination, and metabolism. | | 1977 | 411198 |
| chronic toxicity of 2,5,4'-trichlorobiphenyl in young rhesus monkeys. ii. histopathology. | | 1977 | 411199 |
| influence of cage material on amount of zinc in blood of the rhesus monkey (macaca mulatta). | | 1977 | 411229 |
| [effect of a poly i-poly c complex with poly-l-lysine on experimental tick-borne encephalitis]. | the influence of the poly(i)-poly(c) complex with poly-l-lysine on the development and course of experimental tick-borne encephalitis was studied in macaca rhesus monkeys. prophylactic administration of the substance under study, although not preventing the disease, modified its course and facilitated recovery of the animals. poly(i)-poly(c) and its complex with poly-l-lysine were shown to have no effect on production of infectious virus or its antigen demonstrable by the immunofluorescence proc ... | 1977 | 411260 |
| limb blood flow in the presence of a tourniquet. | there is little accurate data on the blood flow to a limb distal to the site of application of a tourniquet. this has been studied in rhesus monkeys with 50 mu diameter microspheres labelled with 51cr and by the washout of 22na injected into the tissues. one limb was exsanguinated and the circulation occluded with a pneumatic tourniquet and the opposite limb used as a control. the results show that blood flow to the occluded limb is less than 1 per cent of the flow to the control limb. it is unl ... | 1977 | 411320 |
| evolution and regression of aortic fatty streaks in rhesus monkeys. | | 1977 | 411341 |
| [ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. ii. mid-phase changes of the damaged retinal pigment epithelial cells (author's transl)]. | | 1977 | 411360 |
| endocrine activation and altered muscle metabolism after hemorrhagic shock. | studies were conducted to examine glucose and amino acid metabolism by skeletal muscle isolated from rhesus monkeys before and sequentially after an episode of resuscitated hemorrhagic shock. after shock and reinfusion, the tissue exhibited decreased effect of insulin on glucose utilization increased leucine oxidation, and a reduced rate of leucine incorporation into protein. these changes were observed 15 min after reinfusion and persisted in part for at least 3 days. all of the observed abnorm ... | 1977 | 411378 |
| behavioural and hormonal responses of male rhesus monkeys introduced to females in the breeding and non-breeding seasons. | six adult male rhesus monkeys were introduced individually to an all-female group for 10 days during the mating season. the initial aggressive responses of the females were rapidly replaced by positive social behaviour, and each male achieved alpha status and had access to social and sexual partners. a repetition of this paradigm in the non-breeding season produced significantly more female aggression, and no male attained high rank or engaged in sexual or other social behaviour. male testostero ... | 1977 | 411396 |
| comparison of cardiorenal functions between women and female rhesus macaques. | selected cardiorenal functions for conscious and chaired rhesus macaques were compared directly and indirectly with corrections for body weights and surface areas to well-established base-line values for human subjects. certain functional differences between species and conditions of measurement do not allow all experimental results from the rhesus macaque to be extrapolated to man. however, this comparative study provides evidence that can be useful in attempting to evaluate cardiorenal data fr ... | 1977 | 411401 |
| comparative pharmacology of amphotericin b and amphotericin b methyl ester in the non-human primate, macacca mulatta. | the pharmacokinetics of amphotericin b methyl ester hydrochloride (ame) and commercial deoxycholate-stabilized amphotericin b (amb) were compared after single doses of 5 mg and 1 mg/kg of body weight, respectively, given intravenously in a period of 3 h to adult female rhesus monkeys (macaca mulatta). by bioassay, the concentrations of ame were 12.2 to 7.2 times higher in the serum and 7.8 to 2.5 times higher in the urine during the 8 h after infusion. the decline in concentrations of the drugs ... | 1977 | 411419 |
| vascular clearance of venezuelan equine encephalomyelitis viruses as a correlate to virulence for rhesus monkeys. | the epizootic trinidad donkey strain of venezuelan equime encephalomyelitis virus (vee) was cleared slowly from the circulation of rhesus monkeys following intravenous inoculation, while the live, attenuated vaccine strain, tc-83, was cleared rapidly. the efficent clearance of tc-83 vaccine may be a factor in the lower viremia and benign course of tc-83 virus infection in rhesus monkeys. | 1977 | 411457 |
| effects of suloctidil on lipid metabolism in experimental animals. | a novel potent vasoactive agent, 1-(4-isopropyl-thiophenyl)-2-n-octylaminopropanol (suloctidil, sulocton), lowers excess of plasma cholesterol and tends to normalize the plasma hyperbetalipoproteinemia of rhesus monkeys fed a high-cholesterol, high-fat diet. the drug shows an inhibitory effect on the cholesterol biosynthesis in rat liver homogenates. | 1977 | 411499 |
| luteinizing hormone and progesterone secretion during sexual maturation of the rhesus monkey: short luteal phases during the initial menstrual cycles. | | 1977 | 411527 |
| neurophysiological correlates of sensory discrimination performance to electrical cutaneous stimuli in rhesus monkey. | | 1977 | 411542 |
| limbic and sensory connections of the inferior parietal lobule (area pg) in the rhesus monkey: a study with a new method for horseradish peroxidase histochemistry. | the caudal part of the inferior parietal lobule (area pg) was injected with horseradish peroxidase (hrp) in 6 hemispheres of 5 rhesus monkeys. the retrograde transport of hrp resulted in the labeling of neurons in diverse cortical and subcortical areas. in cortex, labeled neurons were noted in prefrontal cortex (areas 8, 45, 46), in the banks of the intraparietal and superior temporal sulci, in medial parietal cortex, in cingulate cortex, in the retrosplenial area, in area tf and the caudal port ... | 1977 | 411543 |
| projections from the paraventricular nucleus to the zona externa of the median eminence of the rhesus monkey: an immunohistochemical study. | immunoperoxidase techniques and light microscopy were used to investigate the origin of the fibers containing vasopressin, oxytocin and related neurophysins (neurohypophyseal peptides), in the zona externa of the median emience of the rhesus monkey. unilateral lesions were produced in the paraventricular nucleus using a modified halasz-type knife. complete destruction of the paraventricular nucleus resulted in a total depletion of all four neurohypophyseal peptides in the ipsilateral zona extern ... | 1977 | 411546 |
| effect of cyproterone acetate on prolactin secretion in the female rhesus monkey. | adult female rhesus monkeys were given cyproterone acetate orally in doses of 0.04, 0.4, 4 and 40 mg per kg per day for 12 weeks. its effects were assessed on serum prolactin (prl) concentration, the morphology of the prl cells, and the development of the mammary glands. serum prl was relatively unchanged in the control animals from the fourth through the twelfth weeks of the study. in contrast, prl was significantly elevated in each group of drug-treated animals during the same time periods. th ... | 1977 | 411573 |
| effect of dopamine infusion on the hemodynamics of normal and sympathectomized rhesus monkeys in endotoxin shock. | infusion of endotoxin in chemically sympathectomized monkeys caused a fall in the mean aortic pressure, but the cardiac output, stroke volume, and central venous pressure were well maintained. endotoxin-induced tachycardia in monkeys with functional sympathetics was not seen in the sympathectomized animals. infusion of dopamine improved the hemodynamic and cardiovascular status, probably by causing vasoconstriction of the splenic and hepatic artery where the pooling of blood is believed to occur ... | 1977 | 411604 |
| [steroid metabolism in primates. xix. urinary excretion of c21-steroids in cercopithecus aethiops and erythrocebus patas]. | in male cercopithecus aethiops (green monkey; grivet) and erythrocebus patas (dancing red monkey; patas monkey), the pattern of urinary c21 steroids was estimated and compared with those of man, baboon and rhesus monkey. the results indicate diminished 11 beta- and 17 alpha-hydroxylation in steroid biosynthesis as well as diminished delta 4-3-keto reduction and increased 20 beta-reduction in metabolism in these two species. | 1977 | 411649 |
| comparative effects of ursodeoxycholic acid and chenodeoxycholic acid in the rhesus monkey. biochemical and ultrastructural studies. | | 1978 | 411708 |
| an endemic focus of trypanosoma cruzi infection in a subhuman primate research colony. | leishmanial forms of trypanosoma cruzi with multifocal pseudocysts were identified in a deceased adult female rhesus monkey (macaca mulatta) that had been maintained in an outdoor primate colony in southern texas. subsequent clinical investigation of the remainder of the colony identified 20 additional monkeys seropositive for t cruzi. concurrent epizootiologic surveys confirmed the presence of sylvatic reservoirs and triatomine vectors of t cruzi infection and identified a natural t cruzi trans ... | 1977 | 411770 |
| amyloidosis in rhesus monkeys with rheumatoid arthritis and enterocolitis. | generalized amyloidosis was diagnosed by light and electron microscopy in 4 of 5 monkeys (macaca mulatta) that had a history of chronic arthritis or chronic intermittent diarrhea, or both. clinical signs and lesions of arthritis in the monkeys were compatible with diagnostic criteria for rheumatoid arthritis. shigella sp was cultured from 1 monkey, and 2 other monkeys had colonic lesions characteristic of shigellosis. at necropsy, gross changes attributed to amyloid were seen only in the liver. ... | 1977 | 411771 |
| experimental fetal anencephaly in the rhesus monkey: effect on gestational length and fetal and maternal plasma steroids. | | 1977 | 411801 |
| the effects of retraction cords and electrosurgery upon blood pressure and tissue regeneration in rhesus monkeys. | | 1977 | 411811 |
| separation and characterization of plasma lipoproteins of rhesus monkeys (macaca mulatta). | a group of 14 adult male rhesus monkeys was maintained on a low cholesterol-high fat diet. periodically, animals were fasted and blood samples were taken for characterization of the plasma lipoproteins. complete separation of individual plasma lipoprotein classes was not achieved by traditional sequential ultracentrifugation techniques. rather, initial separation of lipoprotein classes according to size was effected and density centrifugation was used subsequently for further separation. at leas ... | 1977 | 411861 |
| effects of luteinizing hormone releasing hormone on the ultrastructure of gonadotrophs in the foetus of the rhesus monkey near term. | eighty micrograms of synthetic luteinizing hormone releasing hormone (lh-rh) were infused systemically into male and female foetuses of rhesus monkeys near term. control animals were given infusions of saline. morphologically, the control gonadotrophs varied from cells filled with secretory granules to highly stimulated cells with numerous cytoplasmic vesicles. in the lh-rh-treated animals, however, many cells showed depletion of secretory granules, dilatation of the endoplasmic reticulum and co ... | 1977 | 411864 |
| control of responding by location of auditory stimuli: adjacency of sound and response. | four rhesus monkeys were trained to respond on one key when a one-second noise burst was presented through one speaker and to respond on a second key when the noise burst was presented through a second speaker. the acquisition of stimulus control was studied under three conditions, in each of which the relationship between the sound source and the response-key positions varied: an adjacent condition in which the noise burst was presented through the key and a response on this key was reinforced; ... | 1977 | 411871 |
| effects of single dose supervoltage whole brain radiation in macaca mulatta. | three groups of four macaca mulatta were exposed respectively to a single dose of 1000, 1500, and 2000 rads of 20 mev whole brain radiation with one animal from each group and a control scheduled for sacrifice at 6, 12, 18, and 24 months. with 1000 rads there were no abnormalities. the characteristic lesions in the animals exposed to 1500 and 2000 rads were small foci of delayed radiation necrosis that in the acute phase were relatively large due to marked local accumulation of edema fluid and a ... | 1977 | 411893 |
| binocular interaction and depth sensitivity in striate and prestriate cortex of behaving rhesus monkey. | | 1977 | 411898 |
| effects of perinatal malnutrition on lipid composition of neural tissues from rhesus monkeys. | | 1977 | 411902 |
| antimalarials. 10. synthesis of 4-substituted primaquine analogues as candidate antimalarials. | primaquine (i) has been extensively used in combination with other drugs in the radical cure of relapsing malaria as well as for prophylaxis or the interruption of transmission. this, coupled with the activity data reported for 4-methylprimaquine (ii), has led to the synthesis of a series of 14 4-substituted analogues of i. in addition, three side-chain analogues of ii were prepared. the compounds were tested for suppressive antimalarial activity against plasmodium berghei in the rane mouse scre ... | 1977 | 411930 |
| fda studies of estrogen, progestogens, and estrogen/progestogen combinations in the dog and monkey. | a study begun by a drug company and taken over by the fda (food and drug administration) in 1970 attempted to assess the role of oral contraceptives in tumorigenesis and clotting abnormalities in animals. the study used ethynerone (mk 665) + mestranol; chloroethynyl norgestrel (wy-4355) + mestranol; anagestone acetate + mestranol; ethynerone, and; mestranol administered at levels up to 25 times the human use level to female beagle dogs and 50 times the human use level to female rhesus monkeys. ... | 1977 | 411941 |
| biotransformation of diethylstilbestrol in the rhesus monkey and the chimpanzee. | diethylstilbestrol (des) is considered a teratogen and a transplacental carcinogen in humans. in order to compare its biotransformation in nonhuman primates to that in humans, a metabolic study was carried out in rhesus monkeys and chimpanzees. after an oral dose of 1 mg/kg [14c]des, approximately 59% of the ingested radioactivity was found in the urine and 28% in the feces of two female rhesus monkeys after 4 days, while in male rhesus monkeys urinary radioactivity accounted for 43% and fecal r ... | 1977 | 411947 |
| [paths of corticosteroid biosynthesis in the adrenal glands of rhesus monkeys]. | in experiments in vitro corticosteroid formation from radioactive cholesterol in tha adrenal glands of monkeys (macaca rhesus) was studied. a conclusion was drawn that pregnenolone and its hydroxy-derivatives were of the leading significance in the cortizol and corticosterone synthesis in the adrenal glands of monkeys. progesteron was produced in insignificant amounts and was almost unutilized for steroidogenesis. the formation of 17.21-dioxypregnenolone was revealed; its role in the capacity of ... | 1977 | 412183 |
| effects of light intensity and edge density on visually evoked potentials in rhesus monkeys. | | 1977 | 412219 |
| membrane actions of daunorubicin in mammalian erythrocytes. | fresh erythrocytes from unanesthetized beagles, rhesus monkeys, rabbits and mice have increased susceptibility to hypotonic lysis after incubation for 30 minutes with high concentrations of daunorubicin. the effect is biphasic in that lower concentrations of drug decrease lytic susceptibility. edta diminishes the susceptibility of cells to lysis after treatment with the drug. red cells from humans and from sprague-dawley rats may show either increased or decreased susceptibility to hypotonic lys ... | 1977 | 412241 |