| the chemotherapy of rodent malaria, xxi. action of quinine and wr 122 (a 9-phenanthrenemethanol) on the fine structure of plasmodium berghei in mouse blood. | the effects of quinine and a 9-phenanthrenemethanol, wr 122,455 on the fine structure of plasmodium berghei have been investigated. changes consequent upon quinine treatment were noted in the outer membranes (including those that surround the "food vacuole") and the digestive vacuoles. these changes were followed by cytoplasmic degeneration and vacuolization. wr 122,455 caused morphological changes in at least three areas of the parasite, (1) the outer membranes, (2) the digestive vacuole and (3 ... | 1975 | 1098583 |
| the chemotherapy of rodent malaria, xxii. the value of drug-resistant strains of p. berghei in screening for blood schizontocidal activity. | data are provided on the activity of a variety of antimalarial drugs against drug-sensitive and drug-resistant lines of plasmodium berghei in albino mice. parallel data for the response of the drug-sensitive parasites to these compounds in vitro indicate whether the drugs have a chloroquine-like or quinine-like type of action, or neither. the value of this test system for drug evaluation is debated. it is concluded that the in vivo tests do provide a valuable indication of the potential use of a ... | 1975 | 1098584 |
| sudden increase in virulence in a strain of plasmodium berghei yoelii. | the mild and chronic 17x strain of plasmodium berghei yoelii showed a sudden increase in virulence following a period of 110 days in the deep freeze. the enhanced virulence was seen in a very high and early parasite peak in the blood and a 100% mortality of all infected mice. the exalted virulence remained unaltered following a number of blood transfers of the strain and after four cyclical transmissions through anopheles stephensi. enzyme pattern studies revealed that the virulent strain posses ... | 1975 | 1098585 |
| role of complement components in the susceptibility to plasmodium berghei infection among inbred strains of mice. | inbred strains of mice, sensitive and resistant to plasmodium berghei infections, including a complement deficient strain were infected with p. berghei. daily levels of parasitaemia were determined and serum levels of complement components (c3 and c5) measured by standard haemolytic assay. serum levels of c3 and c5 were depressed in all strains of mice infected with p. berghei. there was no difference in the infectivity and course of p. berghei infection in the co-isogenic c5 deficient and non-d ... | 1975 | 1098586 |
| chloroquine resistance of plasmodium falciparum in west irian and east kalimantan. | evidence is presented of the chloroquine-resistance in plasmodium falciparum in west irian and east kalimantan as shown by clinical observation and quantitative parasite counts in two patients hospitalized in tokyo where no natural transmission of malaria occurs. the evidence is supported by the determination of plasma chloroquine levels, and in vitro sensitivity tests. the highest plasma level of chloroquine in the patient infected in west irian was 197 ng/ml (fourth treatment) and 435 ng/ml (f ... | 1975 | 1098587 |
| purification and some properties of malarial pigment. | malarial pigment from erythrocytes infected with plasmodium berghei was purified by treatment with sodium dodecyl sulphate solution, followed by incubation with pancreatin. the purified pigment retained the apparently crystalline form of pigment within the parasite, rotated polarised light and had the same solubility characterisation as crude malarial pigment. it contained about 1% iron, all of which could be accounted for in terms of haemin. the iron of the pigment molecule is oxidised by the p ... | 1975 | 1098588 |
| immunological studies in rodent malaria. i: protective immunity induced in mice by mild strains of plasmodium berghei yoelii against a virulent and fatal line of this plasmodium. | mild and virulent lines of plasmodium berghei yoelii are readily distinguished both by their course of infection and by the preference of the virulent line for mature red blood cells. mice given either mild line were fully protected against the virulent p.b. yoelii one week after they had become negative. mice given the mild line of p.b. yoelii 17x were fully protected against a challenge by the virulent line on the third day of infection (d+3). mice given the mild and virulent lines of p.b. yoe ... | 1975 | 1098589 |
| the chemotherapy of rodent malaria, xxiii causal prophylaxis, part ii: practical experience with plasmodium yoelii nigeriensis in drug screening. | data are presented on the causal prophylactic action of about 100 compounds of various types against plasmodium yoelii nigeriensis n67 in mice. examples are given to show how action against pre-erythrocytic schizonts may be differentiated from action on emerging erythrocytic stages. in a series of 35 8-aminoquinolines, all but 10 showed definite causal prophylactic activity at tolerated doses. the data permit the compounds to be ranked in order of activity, and many are shown to be more active i ... | 1975 | 1098590 |
| a comparison of pigment from schistosoma mansoni and plasmodium berghei. | the structures of malarial and schistosomal pigment within the parasites are distinct. the two pigments are distinguishable both before and after extraction from host liver. | 1975 | 1098591 |
| antimalarials: screening of (orally administered) silver solfonamides against plasmodium berghei. | orally administered silver sulfadiazine is effective against plasmodium berghei. attempts to synthesize an active analogue with antimalarial activity failed. although several of the analogues were chemically stable (like silver sulfadiazine) in sodium chloride, none of the analogues were biologically active. this suggests that the antimalarial activity of silver sulfadiazine is stereo-specific. | 1975 | 1098869 |
| thiosemicarbazones and hydrazones of alpha-methylchalkone as potential chemotherapeutic agents. | the effectiveness of chalkones and derivatives as antibacterial and antifungal agents stimulated our interest in the possibility of coupling this type of compound with certain hydrazines and thiosemicarbazides to determine the potential chemotherapeutic activity of these combinations as anticancer and antimalarial agents. accordingly, 18 hydrazine and thiosemicarbazide derivatives of alpha-methylchalkone (dypnone) have been synthesized for study as potential antitumor agents in animal tumor syst ... | 1975 | 1099024 |
| alterations in the permeability of mouse erythrocytes infected with the malaria parasite, plasmodium berghei. | | 1975 | 1099038 |
| studies on atp level in erythrocytes of patients with plasmodium falciparum malaria. | | 1975 | 1099162 |
| antimalarial phenanthrene amino alcohols. 3. halogen-containing 9-phenanthrenemethanols. | a series of new 9-phenanthrene amino alcohols has been prepared in which each compound bears from one to five halogen or halogen-containing moieties. a number of these compounds are extremely active against plasmodium berghei in the mouse. some structural requirements for optimal efficacy are considered. | 1975 | 1099200 |
| [malaria tropica--diagnosis and diagnostic errors]. | | 1975 | 1099398 |
| [evaluation of malaria diseases]. | | 1975 | 1099424 |
| [letter: mechanism of hemolysis in the pernicious attack caused by plasmodium falciparum]. | | 1975 | 1099538 |
| [immunodiagnosis of malaria(author's transl)]. | | 1975 | 1099572 |
| malaria prophylaxis. | a trial of malaria prophylaxis was carried out on 744 army personnel who were camping in an endemic area over a 3-month period. three antimalarial drugs were used under strict control and the local population was used as a control, to prove that malaria was present during this time. no cases of malaria occurred in the trial group during this period. | 1975 | 1099692 |
| comparison of tritiated hypoxanthine, adenine and adenosine for purine-salvage incorporation into nucleic acids of the malarial parasite, plasmodium berghei. | this study was accomplished to examine the relative importance of different metabolic precursors of nucleic acid synthesis in the malarial parasite, p. berghei. three possible pathways for incorporation of adenine (type) compounds exist: 1) incorporation via hypoxanthine, 2) via adenine, or 3) via adenosine. the parasitized cell and erythrocyte-free malarial parasite were both examined because of possible metabolic differences that could be encountered. hypoxanthine was clearly the best precurso ... | 1975 | 1099747 |
| surveillance of some infectious diseases among aircrew personnel in southeast asia. | a 2-year analysis of specimens among aircrew personnel in southeast asia is reported. stool specimens were examined for intestinal parasites and enteric bacteria, blood smears for blood parasites, and sera tested for transaminases (sgot) and antibodies to entamoeba histolytica, toxoplasma gondii, chikungunya and japanese encephalitis viruses, rickettsia tsutsugamushi, leptospira sp. and pseudomonas pseudomallei. one to four specimens each were obtained from 537 adult males and 20 females. there ... | 1975 | 1100040 |
| [duration of action of the pyrimethamine-sulfametopyrazine combination in a plasmodium falciparum endemic zone]. | the duration of action of the drug antemal, a combination of pyrimethamine and sulfametopyrazine, was eveluated in bobo-dioulasso, upper volta, west africa, and endemic zone for plasmodium falciparum malaria. the study was held during the season of maximum malaria transmission. 79 persons presenting with an acute attack of malaria were studied; 37 persons received a single dose of chloroquine sulfate (nivaquine), at a dose of 15 mg./kg.; 42 persons received a single dose of antemal at a dose of ... | 1975 | 1100287 |
| mass isolation of anopheles stephensi salivary glands infected with malarial sporozoites. | | 1975 | 1100801 |
| antimalarials. 7.2,8-bis(trifluoromethyl)-4-quinolinemethanols. | based on the high antilalarial activity of alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol, ten additional 2,8-bis(trifluoromethyl)-4-quinolinemethanols were prepared in which the amino alcohol side chain was structurally varied. synthesis of the compounds is described and antimalarial activity data against plasmodium berghei are presented and discussed in terms of the structure variations. | 1975 | 1100828 |
| [malaria in children, with special reference to cerebral malaria (author's transl)]. | those who live in areas where malaria is endemic, acquire immunity by continuous contact. this immunity cannot be acquired during a short holiday. children in endemic areas acquire a more severe form of malaria during the period of developing immunity and more often suffer complications like acute hemolytic anemia and, in the case of plasmodium falciparum infection, cerebral malaria. this is a report of 39 cases of cerebral malaria which corresponds to an acute encephslopathy with high temperatu ... | 1975 | 1100897 |
| [problem of malaria and antimalarial measures in northern afghanistan. 1. malaria in northern afghanistan]. | | 1975 | 1101014 |
| [the problem of the transfer of malaria across the boundaries of the ussr]. | | 1975 | 1101019 |
| evidence for a malaria mitogen in human malaria. | | 1975 | 1101075 |
| probable chloroquine-resistant plasmodium falciparum malaria from mozambique a case report. | a female patient with plasmodium falciparum malaria apparently resistant to chloroquine is descirbed. she had recently returned from mozambique, which may prove to be a new endemic are with resistant strains. the infection was successfully treated with quinine. | 1975 | 1101388 |
| neutralizing antibody in rodent malaria. | small numbers of rat erythrocytes infected with viable p. berghei, when inoculated into susceptible rats together with hyperimmune rat serum (his), are fully neutralized. serum from convalescent rats delays the onset of patency but does not neutralize. the neutralizing efficiency of his rises in proportion to the number of successive reinoculations of hyperimmune rats. in contrast, mice inoculated with parasites together with either his or normal rat serum succumbed to the disease at the same ti ... | 1975 | 1101458 |
| some effects of partial malaria suppression in ugandan children during the first 3 years of life. | | 1975 | 1101459 |
| letter: the durian season in peninsular malaysia as a factor in the epidemiology of malaria. | | 1975 | 1101460 |
| letter: multiple thick films on the same slide. | | 1975 | 1101462 |
| comparison of a 9-phenanthrene methanol (wr33063), a 4-quinoline methanol (wr30090), and quinine for falciparum malaria in thailand. | quinine was compared with a 9-phenanthrene methanol (wr33063) and a 4-quinoline methanol (wr30090) for the treatment of 207 patients with falciparum malaria in southeast thailand. quinine eradicated parasitaemia (average 70 hours) more rapidly than either wr30090 (72 hours) or wr33063 (77 hours). but wr33063 had a higher cure rate (92%) than wr30090 (86%) or quinine (85%). the mean duration of fever and of parasitaemia were combined with the failure rate to form an arbitrary efficacy index. usin ... | 1975 | 1101464 |
| longitudinal malaria studies in rural northeast thailand. chloroquine treatment of falciparum malaria infections. | the efficacy of chloroquine in the treatment of falciparum malaria was studied in two villages in northeast thailand, an area endemic for chloroquine-resistant falciparum infections. chloroquine did not appear to reduce the duration or density of parasitemias experienced by asymptomatic villagers, but did benefit, usually temporarily, many subjects with symptomatic or high-density infections. these observations suggest that the high prevalence of chloroquine-resistant infections in the villages ... | 1975 | 1101487 |
| applications of immunofluorescence to the seroepidemiology of malaria. | | 1975 | 1101775 |
| letter: malaria in britain. | | 1975 | 1102056 |
| the cytocentrifuge for the isolation of parasites from the blood. | | 1975 | 1102109 |
| failure to protect mus musculus against plasmodium berghei with footpad injections of killed parasites incorporated in complete freund's adjuvant. | the stimulation of cell-mediated immunity by the injection of antigen from killed parasites incorporated in complete freund's adjuvant did not protect mus musculus from the erythrocytic stages of plasmodium berghei. agglutinating antibodies could not be detected, but delayed hypersensitivity was demonstrable. apparently thymocyte sensitization alone was not sufficient to afford protection. | 1975 | 1102649 |
| enhanced trypanosoma musculi infections in mice with concomitant malaria. | | 1975 | 1102992 |
| t-cell activation in murine malaria. | | 1975 | 1102993 |
| the nature of age immunity to plasmodium berghei in the rat. | the intensity of plasmodium berghei infections decreases as the age of the rat host increases. the nature of this 'age immunity' was investigated. no experimental support was found for innate resistance involving either serum non-antibody factors or changes in the erythrocytes that inhibit parasites in older rats. a cross reacting immune response active against p. berghei was not found. evidence is presented which shows that rats less than 7 weeks old lack at least part of the functional immunol ... | 1975 | 1103066 |
| [course of trypanosoma musculi infections in plasmodium berghi-infected mice (author's transl)]. | trypanosoma musculi brought into plasmodium berghei-infected mice in the later stages of the malaria infection shows rapid, approximately logarithmic multiplication in the peripheral blood. the trypanosome number increases by a factor of 2-9 per day, multiplication of the parasites kills most mice in a few days. many multiplicative forms of the trypanosomes and a few trypanosomes without nuclei are seen in blood smears. histologically and in touch preparations, masses of multiplicative forms of ... | 1975 | 1103389 |
| [altered reproductive behaviour of trypanosoma musculi after several years of passage in mice (author's transl)]. | the modified strain multiplied less in pregnant and in plasmodium berghei-infected mice, more in heavily infected normal mice, and more or less in weakly infected normal mice. the discordant behaviour in weakly infected mice was due to the occurrence in some animals of a second phase of more rapid increase of the parasitemia. this behaviour could be seen occasionally in the original strain, too. in inbred mice (balb/chan) the length of parasitemia clearly depended on inoculum size and height of ... | 1975 | 1103390 |
| fatal falciparum malaria among narcotic injectors. | eleven narcotic injectors from a prison in saigon were hospitalized with falciparum malaria. coma and intense parasitemia were common and eight patients died soon after admission. two of three autopsied cases also had purulent pulmonary infections. no non-addicted prisoners were hospitalized for malaria. nine more unsuspected falciparum infections were found among 29 other addicts in the prison. the clustering of malaria infections among narcotic injectors who had not been in malarious areas ind ... | 1975 | 1103639 |
| acetylator phenotype and response of individuals infected with a chloroquine-resistant strain of plasmodium falciparum to sulfalene and pyrimethamine. | acetylator phenotype was determined in 33 volunteers who were infected with a chloroquine-resistant strain of plasmodium falciparum and who received, for cure, 2 g of sulfalene and 50 mg of pyrimethamine. this drug combination did not cure 5 of 14 rapid acetylators and 3 of 19 slow acetylators. this difference is not significant. plasma levels of non-acetylated sulfalene, acetylated sulfalene, acetylation, and biologic half-life of non-acetylated sulfalene after administration of the combination ... | 1975 | 1103640 |
| comparison of the complement fixation, indirect immunofluorescence, and indirect hemagglutination tests for malaria. | the complement fixation (cf), indirect immunofluorescence (iif), and indirect hemagglutination (iha)tests for malaria were compared by using sera from u.s. citizens with either natural infections or heroin-associated, needle-induced infections. in natural plasmodium vivax infections, the cf, iif, and iha tests apparently detect malarial antibodies equally efficiently for the first 2 months after the onset of symptoms, but the titers obtained by cf and iif rapidly decline within a year, while the ... | 1975 | 1103641 |
| effects of lowered environmental temperature on the growth of exoerythrocytic stages of plasmodium berghei. | the effect of lowered host-environmental temperature upon the development and maturation of the preerythrocytic tissue stages of rodent malaria parasites has been investigated in two strains of plasmodium berghei originating from the highlands of katanga. young albino rats inoculated with massive sporozoite doses of p. berghei nk 65 and maintained for 48 hours at 12 degrees c developed small, stunted tissue schizonts, averaging 11 x 15 microns, of a distinct morphology. control rats kept at room ... | 1975 | 1103642 |
| nucleoside analogs as antiparasitic agents. | | 1975 | 1103685 |
| detection of antibody in white mice infected with plasmodium berghei by means of the indirect immunofluorescence test. | experiments have been conducted in order to test the efficacy of the immunofluorescence test in the detection of antibody in mice infected with plasmodium berghei vincke et zips, 1948. this method enables the detection of antibody in subclinical and latent cases when an occasional parasite only is present in the blood cells. of the various methods used for the preparation of antigen, and of the various fixatives, a satisfactory immunofluorescence reaction was obtained if unfixed erythrocytes wit ... | 1975 | 1104419 |
| evaluation of a method for in vitro ookinete development of the rodent malarial parasite, plasmodium berghei. | | 1975 | 1104798 |
| chloroquine resistance in malaria: variations of substrate-stimulated chloroquine accumulation. | the response of [14c]chloroquine accumulation to the provision of substrate was evaluated using washed erythrocytes infected with plasmodium berghei cs (chloroquine-susceptible), with p. berghei cr (chloroquine-resistant), with plasmodium vinckei cs, with p. vinckei cr, or with a strain of p. berghei spontaneously resistant to chloroquine, plasmodium berghei yoelii 17x. erythrocytes infected with chloroquine-resistant parasites had a blunted response, particularly to low glucose concentrations. ... | 1975 | 1104805 |
| antimalarials. synthesis and antimalarial activity of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine and derivatives. | the preparation and activity against plasmodium berghei of derivatives of 1-(4-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine are described. replacement of the cinnamoyl group was accomplished by acylation or alkylation of 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)piperazine. modifications of the 5-phenyl group were prepared either by a sequence of reactions involving mandelic ester-pemoline-piperazine pemoline or by the reaction of 5-aryl-2-thio-2,4-oxazolidinedione with piperazine or n ... | 1975 | 1104830 |
| antimalarials. 3. 3-substituted 1-naphthalenemethanols. | the synthesis and antimalarial activity of 22 3-substituted 1-naphthalenemethanols whose substitution was patterned after the antimalarial 2-substituted 4-quinolinemethanols are described. the compounds were active against plasmodium berghei in mice, the most active being 6-chloro-alpha-(dibutylaminomethyl)-3-(3,4-dichlorophenyl)-1-naphthalenemethanol hydrochloride (3b). the naphthalenemethanols tested, 1b and 2b, were not photosensitizing to albino mice. structure-activity relationships between ... | 1975 | 1104831 |
| antimalarials. 10. substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(di-n-butylaminomethyl)methanols. | four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with br, cl, f, or ome in position 3 were synthesized by modifications of standard reactions. the antimalarial activity decreased with increased size of the 3-substituent. the 3-f-4',6,8-cl3 compound was the most active (at 2.5 mg/kg) and was completely curative at 80 mg/kg against p. berghei in mice. | 1975 | 1104832 |
| the treatment of malaria. | | 1975 | 1105541 |
| mefloquine (wr 142,490) in the treatment of human malaria. | mefloquine hydrochloride, a new 4-quinolinemethanol, was administered as a single oral dose to 47 volunteers infected with malaria. treatment resulted in rapid clearence of fever and parasitemia. no recrudescence of parasites was observed after treatment of chloroquine-sensitive infections of plasmodium falciparum. more significantly, in nonimmune persons with chloroquine-resistant infections, 1 gram of mefloquine cured 10 of 12 patients and 1.5 grams cured all 8 patients who received this dose ... | 1975 | 1105787 |
| [subclinic infections and low parasitemia (plasmodium malariae)]. | | 1975 | 1105828 |
| chemosuppressive field trials in thailand. ii. the suppression of plasmodium falciparum and plasmodium vivax parasitemias by a diformyldapsone-pyrimethamine combination. | in an area of thailand where chloroquine-resistant falciparum malaria is known to exist, a chemosuppressive field trial was undertaken to test the efficacy of the preparation diformyldapsone (dfd) combined with pyrimethamine (py) in suppressing falciparum and vivax parasitemias. six hundred and fifty-nine thai villagers were randomly assigned to one of five treatment groups: dfd-py; dapsone (dds)-py; dfd alone; py alone; and placebo. five hundred and ninety-three study subjects completed the 26- ... | 1975 | 1106229 |
| bilateral pleural effusions with plasmodium falciparum infection. | | 1975 | 1106230 |
| intramuscular immunization of mice with irradiated plasmodium berghei sporozoites. enhancement of protection with albumin. | | 1975 | 1106231 |
| [immunosuppression in protozoan infections]. | | 1975 | 1107126 |
| chloroquine in malaria chemotherapy. | | 1975 | 1107292 |
| evaluation of in vitro drug sensitivity of human plasmodium falciparum by incorporation of radioactive isoleucine. | | 1975 | 1107459 |
| antimalarial amino alcohols ii: anthraceneaminoethanols and anthraceneaminopropanols (1- and 9-substituted). | the syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. these compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. the antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published work. | 1975 | 1107515 |
| synthesis of 2-pyridyl-alpha-toluenesulfonates as antimalarials. | a series of substituted 2-pyridyl-alpha-toluenesulfonates was synthesized for antimalarial testing. they were prepared by treating various 2-pyridinols with alpha-toluenesulfonyl chlorides in the presence of an alkali. in tests against plasmodium berghei in mice at 640 mg/kg, only 3,5-dichloro-2-pyridyl-alpha-toluenesulfonate was considered active, i.e., doubled the mean survival time. | 1975 | 1107516 |
| difference in antimalarial activity between certain amino alcohol diastereomers. | a striking difference in antimalarial activity between the diastereomers of 6-bromo-alpha-[2-(1-methylpiperidyl)]-9-phenanthrenemethanol, alpha-(3-peperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol, and alpha-(3-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol was observed. a possible explanation involving the n-o distance and active site binding requirements is suggested. | 1976 | 1107548 |
| editorial: new antimalarial agents. | | 1975 | 1107583 |
| comparative efficiency of pyrimethamine-sulphormethoxine in malaria suppression given as single weekly, fortnightly and monthly doses. | 2. one hundred and seventy inhabitants of the ilorin area, nigeria, were observed over a period of five months during the season of maximum malaria transmission while taking pyrimethamine-sulphormethoxine weekly, fortnightly and every four weeks. 2. there was no episode of malaria parasitaemia in the group receiving weekly doses of 25 mg. pyrimethamine and 0-5 mg. sulphormethoxine throughout the course of the trials. 3. there was one episode of asexual parasitaemia at the second month in the gro ... | 1975 | 1107584 |
| [the campaign against malaria at a crossroad]. | | 1975 | 1107697 |
| [tropical malaria infections. diagnostic and therapeutic problems]. | | 1976 | 1107745 |
| [salmonella bacteremia and cerebral malaria. a case with fatal coincidence of 2 imported diseases]. | | 1976 | 1108331 |
| pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in plasmodium berghei. | | 1975 | 1108883 |
| serum complement and immunity in experimental simian malaria. ii. preferential activation of early components and failure of depletion of late components to inhibit protective immunity. | the role of complement in the control of parasitemia was examined. depletion of late components (3-9) by cobra venom factor did not alter either the degree or course of parasitemia during the pre-immune or immune stages of infection. the pattern of consumption of complement components was therefore examined. concomitant with schizont rupture there was depletion of early-acting components (c1, c4, and c2) of the clasical complement pathway. the magnitude and remporal relationships of the fall wer ... | 1975 | 1110307 |
| deep vascular schizogony in plasmodium fragile: organ distribution and ultrastructure of erythrocytes adherent to vascular endothelium. | erythrocytes infected with plasmodium fragile, like those infected with p. falciparum and p. coatneyi, adhere to vessels in heart, adipose tissue and, to a lesser ex00 nm knob protrusions on the plasma membrane of infected erythrocytes. the close apposition between knobs and endothelium (1 nm or less) excludes macromolecules such as fibrinogen or antibodies as the adhesive force. the components on the membrane responsible for adhesion at the knobs remain unknown. | 1975 | 1111348 |
| malaria (plasmodium knowlesi) merozoites: immunity and the surface coat. | immune serum agglutinated merozoites of plasmodium knowlesi in culture. agglutinated merozoites attached to erythorcytes but were usually unable to invade. marked aggregation of merozoites was associated with reduced invasion of erythrocytes in these cultures. the agglutination and reduced invasion were immunologically specific, for the effect of serum was greatest against homologous strains of p. knowlesi. merozoite agglutination was caused by the binding of surface coats on adjacent parasites. ... | 1975 | 1117140 |
| genetic studies on plasmodium chabaudi: recombination between enzyme markers. | two lines of plasmodium chabaudi differing in three characters have been crossed, using a technique previously described for p. yoelii. one line, termed 47as, was characterized by an electrophoretic form of 6-hosphogluconate dehydrogenase, denoted 6pgd-2, a form of lactate dehydrogenase, denoted ldh-3, and was pyrimethanime-resistant. the second line, termed 10aj, possessed enzyme forms of 6pgd-3 and ldh-2 and was pyrimethamine-sensitive. the cross was made by permitting mosquitoes to feed on a ... | 1975 | 1118185 |
| cytology and kinetics of microgametogenesis and fertilization in plasmodium yoelii nigeriensis. | the sexual development of the microgametocyte of plasmodium yoelii nigeriensis may be subdivided into microgametogenesis which includes exflagellation, dispersal of the gametes and fertilization. under our experimental conditions microgametogenesis takes about 8-15 min at 20 degrees c, the duration of this period being inversely related to temperature. exflagellation takes less than 1 min, subsequent dispersal of gametes may continue for 40 min. we find that exflagellation is totally inhibited i ... | 1975 | 1118188 |
| in vitro incorporation of 1-14c acetate by blood cells of normal ducks and ducks infected with plasmodium lophurae. | several investigations have been made, on a qualitative basis, of in vitro incorporation of 1-14c acetate into the lipids of whole blood from normal ducks and ducks infected with plasmodium lophurae (1,3,4). it was found generally that the percent labeling in blood cells and plasma was higher for infected ducks than for normal ducks. the present study was concerned with quantitative determination of the incorporation of 1-14 c acetate into the lipids of purified erythrocytes (rbc) and leukocytes ... | 1975 | 1120033 |
| plasmodium lophurae: quantitative in vitro incorporation of 14c-1-acetate into lipids. | | 1975 | 1123014 |
| circular mitochondrial dna from the avian malarial parasite plasmodium lophurae. | the avian malarial parasite, plasmodium lophurae, was liberated from duck erythrocytes with antiduck erythrocyte serum and freed from host cell nuclei by differential centrifugation followed by treatment with trypsin and dnaase. total as well as mitochondrial dna isolated from such a preparation of free parasites showed overlapping densities of 1.679 g/ml in cscl density gradients. to retain the structural integrity of mitochondrial dna, the treatment of liberated parasites with trypsin and dnaa ... | 1975 | 1125317 |
| malaria in iowa. | | 1975 | 1127274 |
| erythrocyte receptors for (plasmodium knowlesi) malaria: duffy blood group determinants. | duffy blood group negative human erythrocytes (fyfy) are resistant to infection by plasmodium knowlesi, a simian malaria that infects duffy positive human erythrocytes. the p. knowlesi resistance factor, duffy negative erythrocytes, occurs in high frequency in west africa, where the people are resistant to vivax malaria. this suggests that duffy blood group determinants (fya or fyb) may be erythrocyte receptors for p. vivax. | 1975 | 1145213 |
| plasmodium circumflexum: age as a factor in isodiagnosis in anatidae. | | 1975 | 1149870 |
| new observations on the malaria parasites of rodents of the central african republic - plasmodium vinckei petteri subsp. nov. and plasmodium chabaudi landau, 1965. | the morphology and enzyme forms of malaria parasites isolated from 50 wild caught specimens of thamnomys rutilans from the central african republic have been studied and three distinct species of plasmodium identified. one species has been confirmed as plasmodium yoelii yoelii. morphological features of both the remaining species correspond to those given by landau (1965) in her original description of plasmodium chabaudi. for one of these species the name p. chabaudi has been retained; the othe ... | 1975 | 1155987 |
| merozoite vaccination against plasmodium knowlesi malaria. | free malarial merozoites isolated from in vitro cultures of p. knowlesi and emulsified with freund's complete (fca) or incomplete (fia) adjuvant were used to vaccinate twelve rhesus monkeys against the uniformly lethal infection caused by p. knowlesi. initial challenge of six monkeys with the same parasite variant as used for vaccination produced no detectable infection in three monkeys, while three others developed low-grade parasitaemia (maximum 1.5 per cent), which terminated after 6-11 days. ... | 1975 | 1158390 |
| studies on the transmission of simian malaria. vi. mosquito infection and sporozoite transmission of plasmodium fragile. | anopheles b. balabacensis mosquitoes were infected with plasmodium fragile when fed upon splenectomized macaca mulatta monkeys. highest level mosquito infections were obtained when feedings were made from 2 to 4 days prior to the peak in the parasitemia. transmission to m. mulatta monkeys was obtained via mosquito bite on 2 occasions and via intrahepatic and intravenous inoculation of dissected infected salivary glands on 9 occasions. the prepatent periods ranged from 12 to 17 days with a median ... | 1975 | 1165555 |
| letter: splenectomy and susceptibility to malaria and babesia infection. | | 1975 | 1168520 |
| [the metabolism of c14-labeled phenylalanine and tyrosine in malaria-infected culex females (author's transl)]. | 1. culex females are fed on c14-phenylalanine or c14-tyrosine in sugar solution. autoradiographic studies on homogenated females 1 or 4 days after feeding, show that the labeled amino acids are metabolized on the first day and are not detectable on the fourth day. 2. after increase of the amino acid concentration by saturation of the sugar solution with the unlabeled amino acid, the labeled acid and its metabolites are visable over a longer period of time. 3. phenylalanine is metabolized to tyro ... | 1975 | 1170696 |
| malaria and hemogregarines from lizards of the western caribbean islands of san andrés and providencia. | | 1975 | 1181636 |
| malaria in chordeiles minor (aves: caprimulgidae), an intercontinental migrant. | | 1975 | 1181640 |
| incorporation of nucleic acid precursors by plasmodium cynomolgi in anopheles balabacensis. | autoradiography was used to study the incorporation of tritium-labelled nucleic acid precursors into the sporogonic stages of plasmodium cynomolgi in anopheles b. balabacensis. infected mosquitoes were fed on either 3h-adenine (5, 25 and 50 muci/ml or 3h-thymidine (50 muci/ml) for various periods after the blood meal. 3h-adenine was incorporated into dna and rna of the developing oocysts and the resulting sporozoites. midgut epithelial cells incorporated label from 3h-adenine into nuclear and cy ... | 1975 | 1189024 |
| the seroepidemiology of malaria in middle america. i. longitudinal studies on populations in a low incidence area of el salvador. | serologic profiles were established using the indirect fluorescent antibody test in a longitudinal study of six villages in an interior area of el salvador. positive serologic responses as well as active cases found through the voluntary collaborator posts occurred primarily in adult males, suggesting that much of the malaria experience in the study area resulted from exposure of this segment of the population in more malarious areas where they traveled to engage in temporary agricultural labor. ... | 1975 | 1190363 |
| the seroepidemiology of malaria in middle america. ii. studies on the pacific coast of costa rica. | serologic studies for malaria using the indirect fluorescent antibody technique suggest that active transmission is either absent or very low in 6 villages on the pacific side of costa rica. positive titers (1:20 or higher) were seen in the under-15-year age group in three of the study localities, but only 5 such responses were encountered among 249 people examined in this age range. in the adults (15 years and over) from the same 3 villages there were 68 positive titers among 161 examined. ther ... | 1975 | 1190364 |
| growth in vitro and metabolism of plasmodium vinckei chabaudi. | an in vitro system, based on the rocker dilution technic, has been developed that supports intraerythrocytic growth of a rat-adapted strain of plasmodium vinckei chabaudi from ring to schizont stages; some reinvasion was obtained, although invariably, this was associated with a decrease in parasite numbers. pertinent features were the very high buffer content of the medium and the low oxygen tension of the gaseous phase. lactate production, glucose utilization, and 3h-leucine and 3h-adenosine in ... | 1975 | 1195158 |
| [distribution of apiosomae on the body of fishes in the light of the parasite-host relationship]. | the paper deals with the distribution of apiosomae over the body of fishes. the microecological condition (inhabitation on the skin, fins and gills) are analysed. quantitative regularities are revealed in the distribution of apiosomae which are associated with differences in the inhabitation conditions on various parts of the nost's body and the character or morphological variability resulting from these differences. it was established that the fins, espeically the paired ones, and the surface o ... | 1975 | 1196672 |
| structure and invasive behaviour of plasmodium knowlesi merozoites in vitro. | the structure and invasive behaviour of extracellular erythrocytic merozoites prepared by a cell sieving method have been studied with the electron microscope. free merozoites contain organelles similar to those described in late schizonts of plasmodium knowlesi. their surface is lined by a coat of short filaments. on mixing with fresh red cells, merozoites at first adhere, then cause the red cell surface to invaginate rapidly, often with the formation of narrow membranous channels in the red ce ... | 1975 | 1202413 |
| [antimalaria campaign in the world and in mexico. vectors and pathogenic agents. drugs and insecticides]. | | 1975 | 1205089 |
| parasitic protozoa of the blood of rodents. v. plasmodium vinckei brucechwatti subsp. nov. a malaria parasite of the thicket rat, thamnomys rutilans, in nigeria. | a description is given of the blood stages of a new subspecies of plasmodium vinckei in the blood of naturally infected thicket rats (thamnomys rutilans) from nigeria and experimentally infected mice. sporogony was obtained at 25 degrees c in anopheles stephensi a. quadrimaculatus and a.l. atroparvus, but sporozoites in the salivary glands of the mosquitoes were never infective. the new parasite is differentiated from 7 other species of malaria parasites of african rodents principally on the mor ... | 1975 | 1211764 |
| [description of plasmodium aegyptensis n. sp., presumed parasite of the muridae arvicanthis noloticus in upper egypt]. | | 1975 | 1211772 |