| trypanosomal cardiac valvulitis in vervet monkeys. | quarantined vervet monkeys (cercopithecus aethiops) were infected with trypanosoma brucei (10(4) parasites/animal) in a tsetse free area. thirteen monkeys (11 infected with t.b. rhodesiense and 2 with t.b. brucei) were studied. animals became parasitaemic within one week after infection. the infection time lasted between 21 and 129 days; in 8 monkeys it was between 50 and 70 days. macroscopically massive pericarditis was observed in one, pericardial effusion in one, small apical aneurysms in thr ... | 1985 | 4023556 |
| trypanosoma brucei: infectivity and immunogenicity of cultured parasites. | trypanosoma brucei brucei, derived from the salivary glands of infected tsetse flies (glossina morsitans morsitans) and maintained in culture for over 4 years, were infective to both albino rats and tsetse flies. virulence was markedly enhanced during the first passage in albino rats or tsetse flies. irradiated cultured trypanosomes induced immunity to homologous challenge but not to tsetse fly or blood-induced challenge with the same stock. | 1985 | 4029345 |
| characterization of the trypanosoma brucei 5s ribosomal rna gene and transcript: the 5s rrna is a spliced-leader-independent species. | recent studies have shown that transcription occurs discontinuously for many genes in trypanosoma brucei. to further investigate details of transcription in trypanosomes, the genes for the 5s ribosomal rna from trypanosoma brucei rhodesiense and trypanosoma brucei brucei were cloned. sequence analysis and southern blotting showed the genes to be arranged in highly conserved tandem repeats of approx. 740 bp, which have no relation to the conserved 35-base spliced-leader repeat element. the genes ... | 1985 | 4029619 |
| differentiation in trypanosoma brucei: host-parasite cell junctions and their persistence during acquisition of the variable antigen coat. | acquisition of the variable antigen-containing surface coat of trypanosoma brucei occurs at the metacyclic stage in the salivary glands of the tsetse fly vector. the differentiation of the metacyclic trypanosome in the gland has been studied by scanning electron microscopy and by transmission electron microscopy of thin sections and freeze-fracture replicas. the uncoated epimastigote trypanosomes (with a prenuclear kinetoplast) divide while attached to the salivary gland epithelium brush border ... | 1985 | 4030903 |
| transport of ethanolamine and its incorporation into the variant surface glycoprotein of bloodstream forms of trypanosoma brucei. | the membrane-attached form of the variant surface glycoprotein (mf-vsg) of bloodstream forms of trypanosoma brucei is anchored to the plasma membrane by a hydrophobic c-terminal lipo-oligosaccharide containing ethanolamine. analysis by polyacrylamide gel electrophoresis showed that several different cloned t. brucei strains (strain eatro 110 and variants 117 and 118 of strain 427) incorporated [3h]ethanolamine into both mf-vsg and the soluble vsg derived from it, but not into other proteins. oth ... | 1985 | 4033688 |
| suppression of trypanosoma congolense, t. vivax and t. brucei infection rates in tsetse flies maintained on goats immunized with uncoated forms of trypanosomes grown in vitro. | significant suppression in the incidence of cyclical development of trypanosoma congolense, t. vivax and t. brucei occurred in glossina morsitans centralis maintained on goats immunized with in vitro-propagated uncoated forms of t. congolense, t. vivax and t. brucei, respectively. this was observed when tsetse given a t. congolense-infected feed were subsequently maintained on uninfected immunized goats and also when uninfected tsetse were fed on immunized goats infected with t. congolense, t. v ... | 1985 | 4034247 |
| colostral transfer of antibodies to trypanosoma brucei in goats. | | 1985 | 4037899 |
| inhibition of trypanosoma brucei brucei peptidyl transferase activity by sparsomycin analogs and effects on trypanosome protein synthesis and proliferation. | peptidyl transferase activity of trypanosoma brucei brucei polyribosomes was competitively inhibited by analogs of sparsomycin (ki = 1-100 microm). the analogs were also potent inhibitors of [3h]-leucine and [3h]mannose incorporation into the proteins of intact trypanosomes with little or no effect on overall respiratory rate, suggesting a specific site of action for these analogs on protein synthesis. the peptidyl transferase inhibitors were effective at low concentrations at limiting the proli ... | 1985 | 4038323 |
| tubulin genes of the african trypanosome trypanosoma brucei rhodesiense:nucleotide sequence of a 3.7-kb fragment containing genes for alpha and beta tubulins. | most tubulin genes of the african trypanosome trypanosoma rhodesiense are contained in 3.7-kb tandemly repeating units. one member of the 3.7-kb repeat family has been isolated from a t. rhodesiense genomic library, cloned, and sequenced. the 3646-bp fragment contains a complete alpha-tubulin gene and portions of two beta-tubulin genes. no introns are present. the genes are separated by 634- and 333-bp intergenic regions, which lack typical eukaryotic promoter and poly(a) signal sequences. howev ... | 1985 | 4043732 |
| cysteine eliminates the feeder cell requirement for cultivation of trypanosoma brucei bloodstream forms in vitro. | in all previous studies, bloodstream forms of trypanosoma brucei could be grown in vitro only when supported by a feeder layer of mammalian fibroblasts. we have axenically cultivated bloodstream t. brucei by adding l-cysteine at regular intervals and appropriate concentrations. the optimum cysteine concentration depends on cell density and is close to physiological serum levels. at concentrations greater than 24 mg/liter (2 x 10(-4) m), cysteine was acutely toxic to trypanosome concentrations of ... | 1985 | 4045385 |
| a new method for the rapid purification of both the membrane-bound and released forms of the variant surface glycoprotein from trypanosoma brucei. | a simple new technique was developed for the rapid purification of either the membrane-bound or the released forms of the variant surface glycoprotein of trypanosoma brucei in high yield. whole cells were used as the source of the membrane-bound form, and the supernatant of benzyl alcohol-treated cells was used as the source of the released form. the technique was based on extraction of the acid-treated protein into chloroform/methanol, followed by selective re-partition into aqueous salt soluti ... | 1985 | 4052037 |
| trypanosoma brucei: the extent of conversion in antigen genes may be related to the dna coding specificity. | the boundaries of gene conversion in variant-specific antigen genes have been determined in six clones of trypanosoma brucei. in each clone, antigenic switching involved interaction between two telomeric members of the antat 1.1 multigene family, which share extensive homology throughout their coding regions. all conversion events occurred by substitution of faithful copies of donor sequences. conversion endpoints were nonrandomly distributed. in four clones, the 5' conversion limit was near the ... | 1985 | 4053185 |
| glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to trypanosoma brucei variant surface glycoprotein. | the cooh terminus of the externally disposed variant surface glycoprotein (vsg) of the eukaryotic pathogenic protozoan trypanosoma brucei strain 427 variant mitat 1.4 (117) is covalently linked to a novel phosphatidylinositol-containing glycolipid. this conclusion is supported by analysis of the products of nitrous acid deamination or staphylococcus aureus phosphatidylinositol-specific phospholipase c treatment of purified membrane-form vsg. lysis of trypanosomes is accompanied by release of sol ... | 1985 | 4055788 |
| comparison of african trypanosomes of different antigenic phenotypes, subspecies and life cycle stages by two-dimensional gel electrophoresis. | high resolution two-dimensional polyacrylamide gel (2d gel) electrophoresis and autoradiography were used to analyze the protein gene products of african trypanosomes biosynthetically labelled with [35s]methionine. using cloned populations of parasites it was found that: antigenically different bloodstream trypanosomes from the same serodeme differed only in their variant surface glycoproteins; trypanosoma brucei, t.b. rhodesiense and t.b. gambiense subspecies could be distinguished on the basis ... | 1985 | 4058485 |
| trypanosoma brucei: differentiation of in vitro-grown bloodstream trypomastigotes into procyclic forms. | trypanosoma brucei strain 366d trypomastigotes grown at 37 degrees c in the presence of a human fibroblast cell line formed foci underneath the feeder cells whereas trypanosomes grown in the presence of a human epithelial cell line grew only in the culture supernatant. a culture system was developed to study the differentiation of bloodstream trypomastigotes grown in the epithelial cell system into procyclic trypomastigotes at 27 degrees c. the morphological differentiation into the procyclic fo ... | 1985 | 4067881 |
| protection of the sleeping sickness trypanosome from chemotherapy by different parts of the brain. | | 1985 | 4076024 |
| trypanosoma brucei: five commonly used trypanocides assayed in vitro with a mammalian feeder layer system for cultivation of bloodstream forms. | the in vitro activity of five commonly used trypanocides on bloodstream forms of trypanosoma brucei brucei tc 221 was examined in 24-well culture plates in the presence of bovine fibroblast feeder layer cells. the minimum effective concentrations determined were as follows: berenil 1.0 microgram/ml; samorin 10.0 micrograms/ml; antrycide dimethylsulfate 0.1 microgram/ml; arsobal 0.01 microgram/ml; naganol 1.0 microgram/ml. contrary to values obtained with other in vitro assays, minimum effective ... | 1985 | 4076388 |
| trypanosoma brucei: infection in murine diabetes. | the course of infection due to trypanosoma brucei infection was observed in genetically diabetic and streptozotocin-induced diabetic mice. a strain of t. brucei, treu 667, was used which produces a chronic infection in c57bl/6(b6) mice lasting greater than 60 days. genetic diabetic mice (+db/+db) are obese, and have elevated blood glucose levels, normal levels of insulin, and impaired cell-mediated immunity. their littermates (m+/m+, m+/+db) are of normal weight, and are normoglycemic and immuno ... | 1985 | 4076389 |
| preferential activation of telomeric variant surface glycoprotein genes in trypanosoma brucei. | during an infection, trypanosoma brucei expresses diverse variant surface glycoprotein (vsg) genes in a quasi-sequential order. numerous vsg genes have intrachromosomal locations but many are located adjacent to telomeres. we have tested whether telomeric vsg genes are preferentially activated compared to intrachromosomal vsg genes during an antigenic switch. the frequency with which the istat 11 vsg gene is expressed in first relapse populations has been compared for variant antigenic types (va ... | 1985 | 4079965 |
| nucleotide sequence of the 5s ribosomal rna gene repeat of trypanosoma brucei. | the 750 base pair tandem repeat specifying the 5s ribosomal rna of trypanosoma brucei brucei has been cloned and four independent clones sequenced to completion. the repeat specifies only a single 5s rrna and is unusually long when compared with other 5s gene repeats. the sequenced copies contain a number of sequence polymorphisms similar to those seen in the ribosomal genes of other organisms. by comparison with the consensus sequence for rna polymerase iii promoters ('internal control regions' ... | 1985 | 4079966 |
| characterization of potentially man-infective trypanosoma brucei from an endemic area of sleeping sickness in kenya. | human trypanosomiasis caused by trypanosoma brucei rhodesiense has affected the human population in lambwe valley, western kenya, for more than 20 years. a characteristic feature of the disease has been the repeated recrudescense at restricted residual foci. studies carried out on the incidence of trypanosome infection rates in the vector glossina pallidipes during the last two years have shown high incidence of pathogenic african trypanosomes in the area. an overall trypanosome infection rate o ... | 1985 | 4081544 |
| immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following berenil treatment. | four quarantined vervet monkeys were treated with intramuscular berenil in patent cns infection after experimental trypanosome inoculation with trypanosoma brucei rhodesiense or t. brucei brucei. all four animals relapsed in the post-therapeutic survival time of 37 to 209 days when they had fully developed meningoencephalitis in histological sections with the presence of interstitial intracerebral trypanosomes, which were confirmed in two monkeys by electron microscopy. in both, sequential sampl ... | 1985 | 4082265 |
| [persistence of pleomorphism and the presence of multinuclear forms in experimental infection with t.b. brucei]. | thirty white male mice swiss ico nmri (iops) were inoculated intraperitoneally with blood-forms of t.b. brucei of a strain belonging to the laboratory of parasitology of the medicine faculty of the u.a.m. (autonom university of madrid). this strain was preserved during 8 years through inoculation from mice to mice. this strain was received from the pasteur institute from paris. once infected the mice were submitted to a controle through giemsa coloured smears. the various blood-forms registered ... | 1985 | 4091436 |
| a comparison of counterimmunoelectrophoresis and indirect haemagglutination tests for the immunoepidemiological investigation of kala-azar. | counterimmunoelectrophoresis (cie) using cell-free extracts of leishmania donovani promastigotes and trypanosoma brucei as antigens and indirect haemagglutination (iha) using commercially prepared reagents were compared for their diagnostic efficacy and applicability to immunoepidemiological studies in an area of bangladesh where kala-azar is present. the cie was positive for all parasitologically confirmed cases whereas the iha positivity was only 60%. the t. brucei antigen was equally as good, ... | 1985 | 4095600 |
| characterization of trypanozoon stocks from the south nyanza sleeping sickness focus in western kenya. | 220 trypanosoma (trypanozoon) brucei sp. stocks isolated between 1969 and 1983 from the lambwe valley sleeping sickness focus in south nyanza, western kenya, were characterized by isoenzyme electrophoresis using 12 enzymes. 12 different zymodemes of t. (t.) b. rhodesiense were isolated from patients during the 13-year period and identical stocks were also found in cattle, reedbuck (redunca redunca) and tsetse (glossina pallidipes). cattle may have played an important role in maintaining and incr ... | 1985 | 4095748 |
| [survival time of various consanguineous strains of mice infected with metacyclic forms of trypanosoma brucei]. | | 1985 | 4096556 |
| [experimental infection of mice with trypanosoma brucei brucei: effect of the route of inoculation]. | | 1985 | 4096561 |
| survival and reproductive performance of female glossina morsitans morsitans when maintained on livestock infected with salivarian trypanosomes. | | 1985 | 4096568 |
| the nature of the 4s antigens of the brucei subgroup trypanosomes. | | 1972 | 4111561 |
| diaminobenzidine staining of the mitochondrion of trypanosoma brucei. | | 1972 | 4116720 |
| the efficiency of different diagnostic methods in animal trypanosomiasis; based on surveys carried out in nyanza province, kenya. | | 1972 | 4125897 |
| the capillary-tube agglutination (ca) test. a proposed aid for the diagnosis of trypanosomiasis in the field. | | 1973 | 4126164 |
| separation of the components of t. brucei subgroup 4s (surface) antigen. | | 1973 | 4131627 |
| preliminary observations on the use of the latex agglutination test for detecting circulating trypanosomal antibodies in game animals in the lambwe valley. | the first use of the latex agglutination test (lat) for determining the frequency of circulating trypanosomal antibodies in a sample of game animals collected in the lambwe valley, kenya, is described. the immunological examination of animals belonging to 9 species revealed an incidence of circulating antibody of 25.5%, which was only slightly higher than, and therefore in close agreement with, the results of a concurrent parasitological survey. it is concluded that the lat is very suitable for ... | 1972 | 4132052 |
| antigens and antigenic variability of the african trypanosomes. | | 1974 | 4141372 |
| [trypanosoma brucei gambiense. antigenic study. ii. immunogenic fractions. partial results]. | | 1974 | 4142866 |
| sleeping sickness survey in the serengeti area (tanzania) 1971. i. examination of large mammals for trypanosomes. | | 1973 | 4144952 |
| sleeping sickness survey in the serengeti area (tanzania) 1971. ii. the vector role of glossina swynnertoni austen. | | 1973 | 4144955 |
| isolation of trypanosoma (trypanozoon) rhodesiense from game and domestic animals in musoma district, tanzania. | | 1973 | 4144957 |
| histological examination of wild animals naturally infected with pathogenic african trypanosomes. | | 1973 | 4144958 |
| on the ultrastructure of trypanosoma (trypanozoon) brucei in the course of its life cycle and some related aspects. | | 1973 | 4144959 |
| new animal reservoirs of t. rhodesiense sleeping sickness. | | 1973 | 4147877 |
| the penetration of the peritrophic membrane of the tsetse flies by trypanosomes. | | 1973 | 4149681 |
| on the use of membrane feeding to study the development of trypanosoma brucei in glossina. | | 1974 | 4155241 |
| comparison of specific and relative alanine and aspartate aminotransferases of trypanosoma brucei subgroup trypanosomes. | | 1974 | 4155242 |
| autoimmunity in trypanosome infections. iv. natural infections in hartebeest, hyaena and lion in the serengeti national park, tanzania. | | 1974 | 4155599 |
| lack of incorporation of tritiated thymidine in trypanosoma vivax in vitro. | | 1974 | 4155600 |
| principles of viable preservation of parasitic protozoa. | | 1972 | 4196316 |
| blood parasites of the impala (aepyceros melampus) in the serengeti national park. | | 1973 | 4202696 |
| antigenicity and stilbamidine resistance in trypanosoma brucei rhodesiense. | | 1973 | 4204739 |
| influence of methods of preparation on the infectivity, agglutination, activity, and ultrastructure of bloodstream trypanosomes. | | 1974 | 4206929 |
| effects of immunosuppressive agents on the course of trypanosoma (trypanozoon) brucei infections in heat-stressed mice. | | 1973 | 4207574 |
| autoimmunity in trypanosome infections. i. tissue autoantibodies in trypanosoma (trypanozoon) brucei infections of the rabbit. | | 1974 | 4211823 |
| autoimmunity in trypanosome infections. ii. anti-fibrin-fibrinogen (anti-f) autoantibody in trypanosoma (trypanozoon) brucei infections of the rabbit. | | 1974 | 4214795 |
| the effect of the parasite burden on the curative dose in experimental trypanosomiasis. | | 1973 | 4274036 |
| [isolation of strain- and group-specific partial antigens from trypanosomes of the brucei-group (author's transl)]. | | 1972 | 4282916 |
| changes in the allantoic fluid composition during the development of the chicken embryo. influence of some factors on the viability of trypanosoma brucei. | | 1972 | 4334129 |
| the effect of diphenylamine on terminal respiration in bloodstream and culture forms of trypanosoma brucei. | | 1972 | 4338080 |
| changes in the concentration of lipids at different stages of growth in the blood trypomastigotes of t. brucei. | | 1972 | 4340245 |
| m-chlorobenzhydroxyamic acid--an inhibitor of cyanide-insensitive respiration in trypanosoma brucei. | | 1973 | 4347869 |
| biochemical studies in the vole, microtus montanus. ii. the effects of a trypanosoma brucei gambiense infection on the diurnal variation of hepatic glucose-6-phosphatase and liver glycogen. | | 1973 | 4351430 |
| some interface phenomena in parasitic protozoa and platyhelminths. | | 1973 | 4354671 |
| changes in oxidative metabolism and ultrastructure accompanying differentiation of the mitochondrion in trypanosoma brucei. | | 1973 | 4354962 |
| the nature of the establishment barrier for trypanosoma brucei in the gut of glossina pallidipes. | | 1973 | 4360226 |
| letter: assay of serum enzymes in trypanosomal infection: interference by pyruvate. | | 1973 | 4360227 |
| [studies on the occurrence of trypanosomes in wild carnivores in serengeti national park, tanzania]. | | 1971 | 4400308 |
| experimental trypanosoma brucei infection in lions. | | 1971 | 4400309 |
| some aspects of the surface coat formation in trypanosoma brucei. | | 1971 | 4400311 |
| influence of bloodmeals from different donors on the infection rates of trypanosoma brucei in glossina. | | 1971 | 4400550 |
| sleeping sickness survey in musoma district, tanzania. 3. survey of cattle for the evidence of t. rhodesiense infections. | | 1971 | 4400763 |
| sleeping sickness survey in musoma district, tanzania. iv. examination of wild mammals as a potential reservoir for t.rhodesiense. | | 1971 | 4400764 |
| morphometric data on the ultrastructure of the pleomorphic bloodforms of trypanosoma brucei, plimmer and bradford, 1899. | | 1972 | 4402810 |
| [indirect immunofluorescence method in sleeping sickness (t. rhodesiense) with trypanosoma brucei as antigen]. | | 1972 | 4402811 |
| ethiopian strains of trypanosoma brucei subspecies. | | 1974 | 4413288 |
| the effects of photoperiod and a trypanosoma brucei gambiense infection on the reproductive organs of male microtus montanus. | | 1974 | 4416242 |
| cell disruption and subcellular fractionation of trypanosoma brucei. | | 1974 | 4417067 |
| a statistical study of the sensitivity of the haematocrit centrifuge technique in the detection of trypanosomes in blood. | | 1974 | 4418045 |
| proceedings: effects of infection with trypanosoma brucei brucei on the macrophages of the mouse spleen. | | 1974 | 4419368 |
| proceedings: studies on the fibrinolytic system of rabbits infected with trypanosoma (trypanozoon) brucei. | | 1974 | 4419455 |
| microrespirometry applied to vector forms of trypanosoma brucei brucei. | | 1974 | 4423053 |
| the suppressive effect of trypanosoma brucei on the growth of leishmania mexicana in mice. | | 1974 | 4424335 |
| [the trypanocidal effect of the cleavage products of berenil in acid solution and the possibility of their in vivo recoupling in nmri mice (author's transl)]. | | 1974 | 4432277 |
| the effect of hepes buffered media on the in vitro cultivation of trypanosoma vivax and t. brucei. | | 1974 | 4432278 |
| the nature of immunosuppression in trypanosoma brucei infections in mice. i. the role of the macrophage. | | 1974 | 4435838 |
| quantitative ultrastructural differences between strains of the tryponasoma brucei subgroup during transformation in blood. | | 1974 | 4449091 |
| monosaccharide composition of the surface glycoprotein antigens of trypanosoma brucei. | | 1974 | 4449656 |
| base compisition heterogeneity in kinetoplast dna from four species of hemoflagellates. | | 1974 | 4455258 |
| sleeping sickness survey in musoma district, tanzania: further study on the vector rôle of glossina. | | 1974 | 4458151 |
| letter: some observations on the indentification of trypanosoma (trypanozoon) brucei species strains isolated from non-human hosts. | | 1974 | 4460302 |
| surface antigenic changes in trypanosoma brucei transforming in culture. | | 1974 | 4472494 |
| [trypanosoma brucei gambiense. antigenic study. i. experimental protection of mice. partial results]. | | 1974 | 4480458 |
| [study of infectivity after incubation in the presence of human blood allowing the differentiation of trypanosoma brucei from trypanosoma rhodesiense]. | | 1974 | 4480530 |
| the composition of the trypanosoma brucei subgroup in nonhuman reservoirs in the lambwe valley, kenya, with particular reference to the distribution of t. rhodesiense. | identification by means of the blood incubation infectivity test (biit) of 159 trypanosoma brucei subgroup strains recently isolated from non-human hosts in the lambwe valley, kenya, has defined the distribution in these hosts of both t. brucei and t. rhodesiense in an endemic sleeping sickness area. the presence of a small third group strongly suggestive of a population intermediate between these two species has also been revealed for the first time.repeated testing of a number of these strains ... | 1972 | 4538538 |
| comparative properties of trypanosomal and mammalian thymidine kinases. | | 1972 | 4539354 |
| chromatographic evidence for the synthesis of possible sleep-mediators in trypanosoma brucei gambiense. | | 1973 | 4543926 |
| the response of mice infected with t. brucei to the administration of sheep erythrocytes. | | 1973 | 4544657 |
| a history of rhodesian sleeping sickness in the lambwe valley. | the main events in the spread of rhodesian sleeping sickness around the eastern shores of lake victoria during the 1930s and 1940s are summarized and the history of the disease in the lambwe valley area of western kenya is described since its appearance there in 1959. the area was very receptive to the introduction and dispersal of t. rhodesiense on account of a close association between human communities and their domestic livestock, a large tsetse (glossina pallidipes) population, and game ani ... | 1972 | 4544821 |
| the epidemiology of human sleeping sickness in the lambwe valley, south nyanza, kenya. | human infection with trypanosoma rhodesiense in the lambwe valley area of south nyanza, kenya, was first reported in 1959 although t. gambiense sleeping sickness had been the present there since the turn of the century. the two forms of the disease are associated with the presence of the tsetse glossina fuscipes, which is plentiful and widespread throughout the hinterland, including part of the study area, and g. fuscipes in the thickets near the shores of lake victoria and along some of the riv ... | 1972 | 4544822 |
| trypanosomiasis in domestic livestock in the lambwe valley area and a field evaluation of various diagnostic techniques. | a preliminary survey of 2 073 domestic animals in the lambwe valley, kenya, showed a 7.4% rate of infection with trypanosoma congolense and t. vivax. in comprehensive surveys covering 6 384 domestic stock, pathogenic trypanosomes were found in 17.0% of cattle, 5.0% of sheep, and 2.1% of goats. adults were more often infected than young animals, and males more often than females. t. congolense was the trypanosome most frequently diagnosed, followed by t. vivax and the t. brucei subgroup. t. theil ... | 1972 | 4544823 |
| the role of game animals in the maintenance of endemic and enzootic trypanosomiases in the lambwe valley, south nyanza district, kenya. | rhodesian sleeping sickness and bovine trypanosomiasis were endemic in the lambwe valley of western kenya, where the vector of both diseases was a tsetse fly glossina pallidipes. since a large resident population of game animals also inhabited the valley, a programme was designed to assess the relationships between game animals, tsetse, and trypanosome populations and the results were collated with some aspects of local human ecology and the general epidemiological situation in the valley. of 13 ... | 1972 | 4544824 |