| presence and localization of bacteria in the bovine endometrium postpartum using fluorescence in situ hybridization. | the aim of this study was to investigate bacterial invasiveness of the bovine endometrium during the postpartum period. fluorescence in situ hybridization was applied to endometrial biopsies using probes for fusobacterium necrophorum, porphyromonas levii, trueperella pyogenes, escherichia coli and a probe for bacteria in general (the overall domain bacteria) to determine their tissue localization. holstein cows were sampled at three time points postpartum (t1: 4-12 days postpartum, t2: 24-32 day ... | 2017 | 28237333 |
| a longitudinal cohort study of acute puerperal metritis cases in swedish dairy cows. | acute puerperal metritis affects cows during the early postpartum period and causes fever, fetid vaginal discharge and general depression. the disease is severe and treatment with antimicrobials is often required. this study followed 79 swedish dairy cows with acute puerperal metritis with registered treatment and outcome in terms of recovery. bacteria isolated from the uterus and their susceptibility to penicillin were studied. clinical cases were assigned by participating practitioners who exa ... | 2016 | 27832812 |
| cell based drug delivery: micrococcus luteus loaded neutrophils as chlorhexidine delivery vehicles in a mouse model of liver abscesses in cattle. | the recent who report on antibiotic resistances shows a dramatic increase of microbial resistance against antibiotics. with only a few new antibiotics in the pipeline, a different drug delivery approach is urgently needed. we have obtained evidence demonstrating the effectiveness of a cell based drug delivery system that utilizes the innate immune system as targeting carrier for antibacterial drugs. in this study we show the efficient loading of neutrophil granulocytes with chlorhexidine and the ... | 2015 | 26011247 |
| bloodstream infections among children with juvenile idiopathic arthritis: a prospective study from the onset of disease. | to describe the incidence and nature of bloodstream infections (bsi) among children with juvenile idiopathic arthritis (jia) followed-up prospectively from disease onset. | 2017 | 25436839 |
| diagnosis of acute puerperal metritis by electronic nose device analysis of vaginal discharge in dairy cows. | the objective of this study was to estimate the diagnostic accuracy of an electronic nose device using vaginal discharge samples to diagnose acute puerperal metritis (apm) in dairy cows. uterine fluid was sampled manually with a gloved hand and under sterile conditions for electronic nose device analysis (day in milk (dim) 2, 5, and 10) and bacteriologic examination (dim 5), respectively, and on additional days, if apm was diagnosed during the daily clinical examinations. a dataset containing sa ... | 2014 | 24746098 |
| development of a multiplex pcr for the identification of major pathogenic bacteria of post-partum endometritis in dairy cows. | post-partum period has an important role in cows' breeding due to its effects on reproductive efficiency and subsequent pregnancy. escherichia coli, trueperella pyogenes (arcanobacterium pyogenes), fusobacterium necrophorum and prevotella melaninogenicus are recognized as major pathogens associated with uterine endometrial lesions. the objective of this study was to identify these pathogens using the polymerase chain reaction (pcr) as a culture-independent sensitive method. a total of 172 cows w ... | 2014 | 24325777 |
| identification of a 43-kda outer membrane protein of fusobacterium necrophorum that exhibits similarity with pore-forming proteins of other fusobacterium species. | a pair of primers was designed in an attempt to amplify outer membrane protein (omp) gene of fusobacterium necrophorum based on nucleotide sequence of the omp of fusobacterium nucleatum. further analysis was performed to characterize its molecular properties and phylogeny in the genus fusobacterium. we identified a predicated 43kda outer membrane protein (43k omp) in f. necrophorum, which showed the same properties as other pore-forming proteins of gram-negative anaerobic bacteria according to a ... | 2013 | 23433684 |
| prevalence of group c streptococcus and fusobacterium necrophorum in patients with sore throat: a meta-analysis. | the prevalence of group c beta-hemolytic streptococcus and fusobacterium necrophorum among patients with sore throat in the outpatient setting has not been previously summarized. we set out to derive prevalence information from the existing literature. | 2016 | 28376443 |
| three variants of the leukotoxin gene in human isolates of fusobacterium necrophorum subspecies funduliforme. | leukotoxin is a well-known virulence factor of animal isolates of fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. in this study we found that the leukotoxin gene was present in all tested f. necrophorum isolates from humans. three sequence variants were found, two of which have not been described previously. the sequence types correlated to source of ... | 2017 | 28330774 |
| peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess. | pta is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. it is considered a complication of acute tonsillitis and is the most prevalent deep neck infection (approximately 2000 cases annually in denmark) and cause of acute admission to danish ent departments. teenagers and young adults are most commonly affected and males may predominate over females. however, no studies of age- and gender-stratified incidence rates have previously been published. fu ... | 2017 | 28260599 |
| bacterial invasion of the uterus and oviducts in bovine pyometra. | pyometra is a common disease of cattle that causes infertility and thereby financial losses to the cattle industry. bacteria involved in the development and progression of pyometra have been investigated by microbial culture but their tissue invading abilities, which is an important aspect of bacterial pathogenicity and development of lesions, have not been investigated. bacterial invasion of the uterus and oviducts was studied in 21 cows diagnosed with pyometra at the time of slaughter by apply ... | 2017 | 28257873 |
| otogenic temporomandibular arthritis in children. | septic arthritis of the temporomandibular joint (satmj) is a very rare but potentially severe complication of pediatric middle ear infections because it presents risks of tmj ankylosis. | 2017 | 28253398 |
| a rare case of fusobacterium necrophorum liver abscesses. | liver abscesses are an uncommon disease that can present with vague symptoms. fusobacterium necrophorum causing liver abscesses is a rare condition and only a few cases have been reported. an 88-year-old female presented to her primary care physician with one week of fevers, night sweats, chills, fatigue and vague right upper quadrant abdominal pain. she denied nausea, vomiting, constipation, diarrhea and unintentional weight loss. a computed tomography scan of the abdomen showed two liver absce ... | 2017 | 28243433 |
| prevalence of fusobacterium necrophorum in children presenting with pharyngitis. | fusobacterium necrophorum, an obligate anaerobic bacterium, was recently reported to be an important cause of bacterial pharyngitis with a prevalence as high as that of group a streptococcus (gas) in adolescents and young adults. importantly, f. necrophorum is the primary causative agent of the life-threatening lemierre's syndrome, and screening of pharyngeal samples may be warranted for its early detection and prevention. the aim of this study was to determine the prevalences of f. necrophorum ... | 2017 | 28122872 |
| in vivo antianaerobe activity of ds-8587, a new fluoroquinolone, against fusobacterium necrophorum in a mouse model. | ds-8587 is a novel parenteral fluoroquinolone, which has an activity equivalent to sitafloxacin against various pathogens including anaerobes. we examined the in vivo anti-anaerobic activity of ds-8587, and compared it with that of levofloxacin (lvfx), using a murine model of fusobacterium necrophorum-induced liver abscess developed via blood borne infection. mice with liver abscess infection caused by f. necrophorum were treated with saline (control), ds-8587 (0.8, 4, and 20 mg/kg twice daily), ... | 2017 | 28109739 |
| fusobacterium necrophorum pharyngitis complicated by lemierre's syndrome. | we report the case of an 18-year-old woman who was referred to our outpatient clinic because of a 2-week history of sore throat, high fever, and neck tenderness unresponsive to a 7-day amoxicillin/clavulanic acid course. infectious mononucleosis was initially suspected, but an extremely high value of procalcitonin and clinical deterioration suggested a bacterial sepsis, prompting the patient admission to our internal medicine ward. blood cultures were positive for fusobacterium necrophorum. ct s ... | 2016 | 28050168 |
| fusobacterium necrophorum tonsillitis with mild case of lemierre's syndrome. | | 2017 | 28040511 |
| methicillin-resistant staphylococcus aureus as a cause of lemierre's syndrome. | lemierre's syndrome (ls) or jugular vein suppurative thrombophlebitis is well described in literature. the organisms most often responsible are fusobacterium necrophorum or anaerobic flora. we present a case of ls with an atypical microbiologic cause, methicillin-resistant staphylococcus aureus. we also present retrospective review of all ls cases from our institution and identified 2 additional children with ls caused by methicillin-resistant s. aureus. | 2017 | 27977559 |
| the role of fusobacterium necrophorum in pharyngotonsillitis - a review. | fusobacterium necrophorum is a gram-negative anaerobic bacterium that is the causative agent of the invasive disease lemierre's syndrome. in addition, it is also associated with peritonsillar abscess formation and otitis media in small children. recent research has shown that f. necrophorum may be involved in pharyngotonsillitis especially in adolescent and young adults and that it may be the second most common bacterial cause of pharyngotonsillitis after streptococcus pyogenes (group a streptoc ... | 2016 | 27693542 |
| semi-quantitative digital analysis of polymerase chain reaction-electrophoresis gel: potential applications in low-income veterinary laboratories. | the interpretation of conventional polymerase chain reaction (pcr) assay results is often limited to either positive or negative (non-detectable). the more robust quantitative pcr (qpcr) method is mostly reserved for quantitation studies and not a readily accessible technology in laboratories across developing nations. the aim of this study was to evaluate a semi-quantitative method for conventional pcr amplicons using digital image analysis of electrophoretic gel. the potential applications are ... | 2016 | 27733792 |
| [let us not forget the lemierre's syndrome.] | lemierre's syndrome is a dangerous potential sequela of pharyngitis that results in septic thrombophlebitis of the internal jugular vein. a high index of suspicion is needed to consider this diagnosis in the workup of pharyngitis and should be aggressively treated once. gram-negative anaerobic bacteria, mainly fusobacterium necrophorum are implicated. before the antibiotic era, lemierre's syndrome was common and often fatal. but with the introduction of penicillin in the 1940s, the incidence of ... | 2016 | 27727258 |
| application of chitosan microparticles for treatment of metritis and in vivo evaluation of broad spectrum antimicrobial activity in cow uteri. | uterine disease such as metritis is associated with multiple bacterial infections in the uteri after parturition. however, treatment of metritis is challenging due to considerably high antibiotic treatment failure rate with unknown reason. recently, chitosan microparticles (cm) have been developed to exert broad spectrum antimicrobial activity against bacterial pathogens, including multi-drug resistant bacteria, without raising cm resistant mutants. in this study, we tested, using metagenomics a ... | 2016 | 27710834 |
| fusobacterium necrophorum findings in denmark from 2010 to 2014 using data from the danish microbiology database. | fusobacterium necrophorum findings in denmark and estimation of the incidence of f. necrophorum bacteraemia was described using data from the nationwide danish microbiology database (miba). all microbiological reports on any fusobacterium species in denmark were extracted for a period of 5 years from 2010 to 2014 from miba and from the local department of clinical microbiology. the overall incidence of f. necrophorum bacteraemia from 2010 to 2014 was 2.8 cases per million/year vs 9.4 in the age ... | 2016 | 27704629 |
| lemierre's syndrome: current perspectives on diagnosis and management. | this is a systematic review of cases with lemierre's syndrome (ls) in the past 5 years. ls is characterized by sepsis often evolving after a sore throat or tonsillitis and then complicated by various septic emboli and thrombosis of the internal jugular vein. symptoms include sepsis, pain, and/or swelling in the throat or neck, as well as respiratory symptoms. laboratory findings show elevated infectious parameters and radiological findings show thrombosis of the internal jugular vein and emboli ... | 2016 | 27695351 |
| prevalence of fusobacterium necrophorum in tonsils from patients with chronic tonsillitis. | there was a high prevalence of fusobacterium necrophorum (fn) in patients with chronic tonsillitis in the age group 15-23 years. this indicates that fn might play an important role in the pathogenesis of chronic tonsillitis in this age group, which is also the age group in which chronic or recurrent tonsillitis is most common. | 2017 | 27659315 |
| a systematic review of fusobacterium necrophorum-positive acute tonsillitis: prevalence, methods of detection, patient characteristics, and the usefulness of the centor score. | the purpose of this study was to review the current evidence for an association between fusobacterium necrophorum (fn) and acute tonsillitis (at), to assess the prevalence of fn in at, to identify the better fn detection method, and to characterize the clinical characteristics of fn-positive patients with uncomplicated at. a systematic literature search was conducted in the pubmed, embase, and swemed+ databases for studies reporting on the recovery rates of fn in patients with at. a total of 498 ... | 2016 | 27568201 |
| a rare cause of hemophagocytic lymphohistiocytosis: fusobacterium infection-a case report and review of the literature. | hemophagocytic lymphohistiocytosis (hlh) is a rare syndrome characterized by excessive activation of the immune system. bacterial infections are very rare precipitants of this disease. a 19-year-old gentleman presented with headache, fatigue, and malaise. he was found to be hypotensive, tachycardic, and febrile. broad spectrum antibiotics were initiated, and a lumbar puncture ruled out meningitis. patient progressively developed shock that required use of vasopressors, as well as renal and respi ... | 2016 | 27563473 |
| [sepsis due to fusobacteria in a young adult]. | fusobacteria belong to the normal population of the pharyngeal mucosa as well as the mucosa of the upper airways and the gastrointestinal tract. infections are comparatively rare. the most common causative organism is fusobacterium necrophorum. a well-known infection caused by this germ is lemierre's syndrome. in the presented case, a 19-year-old man (123 kg body weight, 186 cm body length) was found dead in his bed in the morning after having complained of muscular fatigue and vomiting the prev ... | 2016 | 27386622 |
| severe sepsis associated with lemierre's syndrome: a rare but life-threatening disease. | background. the incidence of lemierre's syndrome has increased in the past decade. this posttonsillitis complication may be life threatening. case presentation. a 19-year-old patient was admitted to surgical intensive care unit of a french university hospital for high fever, low blood pressure, and haemoptysis following a sore throat episode. blood analysis revealed a thrombopenia, an acute renal failure, and an elevated lactate serum. fusobacterium necrophorum was found in blood cultures. compu ... | 2016 | 27127661 |
| modulation of the orodigestive tract microbiome in hiv-infected patients. | more than 37 million people are living with human immunodeficiency virus 1 (hiv), and more people than ever received lifesaving antiretroviral therapy worldwide. hiv-1 infection disrupts the intestinal immune system, leading to microbial translocation and systemic immune activation. we investigated the impact of hiv-1 infection on the gi microbiome and its association with host immune activation. the data indicated that the microbiome was different in hiv-positive and hiv-negative individuals. t ... | 2016 | 27109275 |
| potential bacterial core species associated with digital dermatitis in cattle herds identified by molecular profiling of interdigital skin samples. | although treponemes are consistently identified in tissue from bovine digital dermatitis (dd) lesions, the definitive etiology of this debilitating polymicrobial disease is still unresolved. to study the microbiomes of 27 dd-infected and 10 healthy interdigital skin samples, we used a combination of different molecular methods. deep sequencing of the 16s rrna gene variable regions v1-v2 showed that treponema, mycoplasma, fusobacterium and porphyromonas were the genera best differentiating the dd ... | 2016 | 27016768 |
| fusobacterium necrophorum otitis and mastoiditis in infants and young toddlers. | there is an increased recovery of fusobacterium necrophorum from cases of otitis media and mastoiditis in the pediatric population. these infections may be highly severe, causing local osteomyelitis, bacteremia, and lemierre's syndrome. the severity and difficulties in providing optimal treatment for these infections may be especially difficult in this age group due to immunological immaturity and delayed presentation. in this review of literature, we present and analyze the clinical presentatio ... | 2016 | 26951264 |
| hepatic abscess caused by fusobacterium necrophorum after a trip to the dentist. | a 57-year-old man with no significant medical history was admitted to the hospital, with high-grade fever and right upper quadrant pain. he was found, on abdominal ultrasound, to have a right lobe hepatic cystic lesion. mri of the abdomen confirmed a hepatic abscess. cultures obtained under ct guidance showed the abscess to be caused by fusobacterium necrophorum. this is a rare bacterium that can cause potentially fatal liver abscesses. following drainage and intravenous antibiotic treatment, th ... | 2016 | 26933183 |
| lemierre syndrome of the femoral vein, related to fusobacterium necrophorum abscess of vastus lateralis. | lemierre syndrome is an uncommon, potentially lethal disorder combining acute oropharyngeal infection caused by fusobacterium necrophorum, with jugular vein suppurative thrombosis, complicated by anaerobic sepsis with secondary multiple metastatic abscesses. optimal treatment outcome with reduced or absence of sequelae can be achieved with early diagnosis. | 2016 | 26899519 |
| a case of lemierre's syndrome with a brief literature review. | the last fifteen years have witnessed a remarkable increase in the reported cases of lemierre's syndrome (ls), which was once called the forgotten disease. ls manifests as oropharyngitis and a blood stream infection with fusobacterium necrophorum and internal jugular vein thrombosis. ls is a challenge for clinicians, as it is often difficult to diagnose and is associated with significant morbidity. in recognition of the importance of raising the awareness about rare diseases, herein, we describe ... | 2017 | 26876432 |
| gastrointestinal variant of lemierre's syndrome complicating ruptured appendicitis. | fusobacterium necrophorum is a non-spore-forming, obligate anaerobic, filamentous, gramnegative bacillus that frequently colonizes the human oral cavity, respiratory tract, and gastrointestinal tract. fusobacterium species have rarely been implicated in cases of gastrointestinal variant of lemierre's syndrome. we describe a case of f. necrophorum bacteremia associated with suppurative porto-mesenteric vein thrombosis (pvt) following acute ruptured appendicitis. in addition, we list the documente ... | 2015 | 26793462 |
| unusual neurological presentation of fusobacterium necrophorum disease. | a 2-year-old girl presented to hospital, with reduced consciousness and fever. she had a 4-week history of fever treated with two courses of amoxicillin for tonsillitis diagnosed in primary care. neuroimaging revealed multiple cerebral abscesses and subdural empyema. pus aspirated from the intracranial collections grew fusobacterium necrophorum and meropenem was started. following neurosurgery, the patient continued to be agitated with fluctuating fever. she underwent close monitoring with regul ... | 2016 | 26759436 |
| the forgotten one: lemierre's syndrome due to gram-negative rods prevotella bacteremia. | lemierre's syndrome (ls) is a rare syndrome caused by an acute oropharyngeal infection with metastatic spreading. it was described in 1939 as jugular vein septic thrombophlebitis associated with retropharyngeal infection. different organisms can cause ls, such as fusobacterium species, peptostreptococcus, group b and c, streptococcus, staphylococcus, and enterococcus species, but the most commonly isolated pathogen is fusobacterium necrophorum, a common oral flora. management depends on the init ... | 2016 | 26751621 |
| a case of lemierre's syndrome with septic shock and complicated parapneumonic effusions requiring intrapleural fibrinolysis. | lemierre's syndrome is a septic thrombophlebitis of the internal jugular vein, which can lead to severe systemic illness. we report a case of an otherwise healthy 26-year-old man who suffered from pharyngitis followed by septic shock requiring intubation and vasopressor support from fusobacterium necrophorum bacteremia. the septic emboli to his lungs caused complicated bilateral parapneumonic effusions, which recurred after initial drainage. he required bilateral chest tubes and intrapleural tpa ... | 2015 | 26744664 |
| bacteraemia caused by fusobacterium necrophorum: a clinical approach to lemierre's syndrome. | | 2015 | 26738404 |
| [loco-regional complications of pharyngitis: the example of lemierre's syndrome]. | pharyngitis is a common cause of consultation in ambulatory medicine. although it is benign in most cases, serious complications may happen and must be recognized quickly. lemierre's syndrome is one of them. it consists in the association of thrombosis of the internal jugular vein and septic emboli that generally involve the lungs and is classically associated with fusobacterium necrophorum. it is usually found in young and healthy adults and has an estimated mortality of 5%. diagnosis relies es ... | 2015 | 26638515 |
| bovine vaginal strain kocuria kristinae and its characterization. | kocuria spp. are widely distributed in nature. they are gram-positive, coagulase-negative, coccoid bacteria belonging to the family micrococcaceae, suborder micrococcineae, order actinomycetales, class actinobacteria. in general, limited knowledge exists concerning the properties associated with the representants of the genus kocuria, kocuria kristinae as well. following our previous results, k. kristinae kk2014 biocenol(™) (ccm 8628) was isolated from vagina of a healthy cow. its taxonomical al ... | 2016 | 26494240 |
| pediatric disseminated lemierre syndrome in 2 infants: not too young for an ancient disease. | the lemierre syndrome is characterized by an oropharyngeal infection, thrombosis of the internal jugular vein, and multiple septic metastases. fusobacterium necrophorum is a common cause of it. the incidence is 0.6 to 2.3 cases per million with a mortality rate of 4% to 18%. its fast evolution and the possibility of severe complications require a high index of suspicion for its diagnosis. we present 2 infants with lemierre syndrome. the younger case, a 6-month-old infant, was fully recovered. in ... | 2015 | 26466147 |
| erratum for holm et al., activation of the contact system at the surface of fusobacterium necrophorum represents a possible virulence mechanism in lemièrre's syndrome. | | 2015 | 26450975 |
| lemierre disease: a case with multilevel epidural abscess and aggressive neurological weakness: case report and literature review. | lemierre disease is a rare postanginal sepsis caused by the anaerobe fusobacterium necrophorum. it is associated with a pharyngitis that progresses quickly to thrombophlebitis of the internal jugular vein and metastatic abscesses to pulmonary, soft tissue, articular, and organ systems. it is rarely associated with spinal epidural abscesses. because of the increasing antibiotic resistance, its incidence is on the rise. | 2017 | 26368857 |
| clival osteomyelitis and hypoglossal nerve palsy--rare complications of lemierre's syndrome. | an increasingly reported entity, lemierre's syndrome classically presents with a recent oropharyngeal infection, internal jugular vein thrombosis and the presence of anaerobic organisms such as fusobacterium necrophorum. the authors report a normally fit and well 17-year-old boy who presented with severe sepsis following a 5-day history of a sore throat, myalgia and neck stiffness requiring intensive care admission. blood cultures grew f. necrophorum and radiological investigations demonstrated ... | 2015 | 26323975 |
| lemierre syndrome presenting as acute mastoiditis in a 2-year-old girl with congenital dwarfism. | lemierre syndrome is defined by septic thrombophlebitis of the internal jugular vein caused by fusobacterium. historically, these infections originate from the oropharynx and typically are seen in older children, adolescents and young adults. more recently, otogenic sources in younger children have been described with increasing frequency. we present a case of a two-year old, who initially developed an otitis media with perforation of the tympanic membrane and went on to develop mastoiditis and ... | 2015 | 26294952 |
| invasive fusobacterium necrophorum infections and lemièrre's syndrome: the role of thrombophilia and ebv. | the purpose of this investigation was to describe the clinical spectrum of invasive fusobacterium necrophorum infections and lemièrre's syndrome, to examine the role of underlying thrombophilia and concomitant mononucleosis in lemièrre's syndrome, and to describe thromboembolic complications. patients with invasive f. necrophorum infections were identified either prospectively or retrospectively through the regional database of clinical microbiology from 2000 to 2015. patient records were review ... | 2015 | 26272176 |
| lemierre's syndrome: a neglected disease with classical features. | we report the case of a previously healthy, immunocompetent 23-year-old male who presented to the emergency department with general malaise, difficulty in breathing, fever, and chest pain. he reported a two-week history of progressively worsening sore throat that he presumed to be a viral infection and thus initially neglected. however, when his condition deteriorated, he was admitted to hospital acutely unwell and in respiratory distress. he quickly developed septic shock requiring intensive ca ... | 2015 | 26257787 |
| fusobacterium necrophorum presenting as isolated lung nodules. | fusobacterium necrophorum causes lemierre's syndrome - a dramatic and distinct condition beginning with pharyngitis before proceeding to internal jugular vein septic thrombophlebitis and respiratory tract infection in otherwise healthy individuals. it is rare, but by far the most common pathway to parenchymal lung disease with this organism. here we describe we a 34 year old healthy lady who was nontoxic without any antecedent illness who presented with lung nodules due to fusobacterium necropho ... | 2015 | 26236610 |
| lemierre's syndrome associated with periodontal injury-derived odontogenic infection that did not respond to meropenem. | a 33-year-old previously healthy man injured his gums and subsequently developed dyspnea and fever. a chest x-ray showed nodules and infiltrates in both lungs, and the patient was initially diagnosed with pneumonia and administered meropenem hydrate, although his symptoms did not improve. a blood culture identified fusobacterium necrophorum, and thrombophlebitis in the internal jugular vein of the neck was observed on computed tomography and ultrasound scans. we replaced the meropenem with clind ... | 2015 | 26179541 |
| [pleuro-pneumonia revealing septic thrombophlebitis of the jugular vein: think about the lemierre's syndrome]. | infection by fusobacterium necrophorum, a gram negative anaerobic bacteria, can lead to the development of lemierre's syndrome, an uncommon but potentially fatal infection of the internal jugular vein. since the introduction of antibiotics, the morbidity and mortality associated with this syndrome have been dramatically reduced. this syndrome is characterized by a pharyngeal infection, which leads to the development of septic thrombophlebitis of the internal jugular vein with septic emboli, whic ... | 2016 | 26163394 |
| tonsillar colonisation of fusobacterium necrophorum in patients subjected to tonsillectomy. | fusobacterium necrophorum is a well-known cause of lemirre's disease and accumulating evidence support its pathogenic role in peritonsillar abscess while its role in recurrent and chronic tonsillitis is uncertain. the objective of this study was to assess the prevalence of oropharyngeal colonisation with f. necrophorum and beta-haemolytic streptococci in a cohort of patients scheduled for tonsillectomy due to recurrent or persistent throat pain, and to evaluate the dynamics of colonisation with ... | 2015 | 26159432 |
| importance of blood cultures to aid the diagnosis of lemierre's syndrome. | this is a case report of lemierre's syndrome, a septic thrombophlebitis of the internal jugular vein (ijv) usually preceded by pharyngitis and bacteraemia with an anaerobic organism. fusobacterium necrophorum is ananaerobic gram-negative bacillus and is the most common organism reported to cause lemierre's syndrome which usually occurs one to three weeks post pharyngitis or oropharyngeal surgery. a 21-year-old patient presented with signs of sepsis and a history of sore throat, fever, and tender ... | 2015 | 26117393 |
| disposition of ceftiofur and its active metabolites in fallow deer (dama dama) following single-dose intravenous and intramuscular administration. | septicemia and foot infections associated with fusobacterium necrophorum , pasturella multocida, and streptococcus suis in captive fallow deer (dama dama) are reasonably treated with ceftiofur hydrochloride. this study describes the disposition of ceftiofur after single-dose intravenous and intramuscular administration of 3.65±0.1678 mg/kg in six female adult fallow deer using a nonrandomized crossover design and a 7-day washout period. serial blood samples were collected for 12 hr postdrug admi ... | 2015 | 26056876 |
| uterine necrosis associated with fusobacterium necrophorum infection. | fusobacterium necrophorum is infrequently implicated as a pathogenic organism. when pathogenic, the typical clinical presentation is that of pharyngitis, cervical adenopathy, and unilateral thrombophlebitis of the internal jugular vein. infections caused by fusobacterium necrophorum within the fields of obstetrics and gynecology have been infrequently reported. we describe a 19-year-old woman who underwent a cesarean delivery complicated by sepsis and purulent uterine necrosis secondary to fusob ... | 2015 | 26000185 |
| fusobacterium necrophorum and other fusobacterium spp. isolated from head and neck infections: a 10-year epidemiology study in an academic hospital. | fusobacterium spp. from clinical specimens are increasingly reported. we sought to describe the epidemiology, the microbiological, and the clinical characteristics of head and neck infections caused by fusobacterium necrophorum and other fusobacterium spp. | 2015 | 25988544 |
| infections caused by fusobacterium in children: a 14-year single-center experience. | this study aimed at reviewing our experience with infections caused by fusobacterium in children. | 2015 | 25929419 |
| challenges in the management of acute mastoiditis in children. | acute mastoiditis (am) is a rare but serious complication of otitis media. recent studies consolidated the role of streptococcus pyogenes as the second most important etiologic agent of am and suggested an increased involvement of a relatively new pathogen (fusobacterium necrophorum). the recently accumulated evidence on am epidemiology in children is conflicting and not convincing in demonstrating clear trends during the last years. while a significant decrease was recorded in the incidence of ... | 2015 | 25903167 |
| liver abscessation and multiple septic pulmonary emboli associated with lemierre's syndrome: a case report. | in lemierre's syndrome, patients first exhibit pharyngitis and peritonsillar abscessation, followed by the development of anaerobic bacterial (usually fusobacterium necrophorum) septicemia and metastatic infections throughout the body. however, these infections rarely affect the liver. we describe a case of lemierre's syndrome, in which the first disease manifestation was liver abscess, for drawing attention of emergency physicians to this rare but fatal disease. | 2015 | 25889618 |
| clinical and biochemical characteristics of patients with fusobacterium necrophorum-positive acute tonsillitis. | fusobacterium necrophorum (fn) is the predominant pathogen in peritonsillar abscesses, which is a relatively frequent complication of acute tonsillitis. the study aimed to explore if fn is a significant pathogen in acute tonsillitis, examine the prevalence of fn in acute tonsillitis patients, and describe the clinical and biochemical characteristics of fn-positive patients. a 6-month prospective study was conducted in a danish general practice with eight physicians. one hundred acute tonsillitis ... | 2015 | 25876001 |
| study: bacterium associated with rare "forgotten" disease also responsible for more sore throats than group a strep in young adults. | new findings show that fusobacterium necrophorum, the bacterium responsible for most cases of lemierre's disease, a relatively rare condition that is sometimes called "the forgotten disease," is also the culprit for more sore throats than group a strep bacterium among college-aged patients. however, as there is no point-of-care test for f. necrophorum, providers need to rely on physical examination when determining whether a sore throat is due to the bacterial infection. in an analysis of 312 co ... | 2015 | 25844434 |
| the effects of iron limitation and cell density on prokaryotic metabolism and gene expression: excerpts from fusobacterium necrophorum strain 774 (sheep isolate). | fusobacterium necrophorum is a gram-negative obligate anaerobe associated with several diseases in humans and animals. despite its increasing clinical significance, there is little or no data on the relationship between its metabolism and virulence. previous studies have shown that bacteria grown under iron-limitation express immunogenic antigens similar to those generated in vivo. thus, this paper describes the relationship between f. necrophorum subsp. necrophorum (fnn) metabolism and the expr ... | 2015 | 25771225 |
| isolated facial vein thrombophlebitis: a variant of lemierre syndrome. | lemierre syndrome is a rare complication of acute tonsillitis. it is caused by the anaerobic bacterium fusobacterium necrophorum and is characterized by bacteremia and septic thrombosis of the internal jugular vein. dissemination of septic emboli may occur. the diagnosis can be difficult since different organs can be involved. we discuss a case of lemierre syndrome in a 35-year-old woman with isolated thrombophlebitis of the facial vein and fusobacteria growth in blood culture. this case emphasi ... | 2014 | 25734123 |
| the clinical presentation of fusobacterium-positive and streptococcal-positive pharyngitis in a university health clinic: a cross-sectional study. | pharyngitis guidelines focus solely on group a β-hemolytic streptococcal infection. european data suggest that in patients aged 15 to 30 years, fusobacterium necrophorum causes at least 10% of cases of pharyngitis; however, few u.s. data exist. | 2015 | 25686164 |
| [a case of lemierre's syndrome with septic pulmonary embolisms]. | a 41-year-old-man with sore throat and fever visited a nearby clinic. he was given antibiotics, but on disease day 11, the left side of his neck had swollen. because chest ct on disease day 16 showed bilateral multiple pulmonary nodules, he was admitted to our hospital. he had septic pulmonary embolisms and thrombophlebitis of the left internal jugular vein, and fusobacterium necrophorum was isolated from the blood and neck pus culture, and we diagnosed him as having lemierre's syndrome. we admi ... | 2014 | 25672140 |
| fusobacterium necrophorum tonsillitis: an important cause of tonsillitis in adolescents and young adults. | the role of fusobacterium necrophorum in tonsillitis in adolescents and young adults was retrospectively investigated by culture examination. we compared the prevalence of f. necrophorum in 212 subjects with confirmed clinical tonsillitis and in 176 subjects with confirmed no clinical tonsillitis. the prevalence of f. necrophorum was significantly higher (p < 0.001) in subjects with clinical tonsillitis (27%) compared to subjects with no clinical tonsillitis (6%). these results clearly demonstra ... | 2015 | 25658551 |
| lemierre's syndrome secondary to community-acquired methicillin-resistant staphylococcus aureus infection presenting with cardiac tamponade, a rare disease with a life-threatening presentation: a case report. | lemierre's syndrome is a rare condition characterized by thrombophlebitis of internal jugular vein, septicemia and septic metastatic infection of different organs. it is preceded by an oropharyngeal infection by anaerobic organisms. community-acquired methicillin-resistant staphylococcus aureus is now emerging as a causative organism in lemierre's syndrome. clinical manifestations vary depending on the organ system affected by the infection. although rare, patients may present with life-threaten ... | 2014 | 25635199 |
| identification of an outer membrane protein of fusobacterium necrophorum subsp. necrophorum that binds with high affinity to bovine endothelial cells. | fusobacterium necrophorum, a gram-negative anaerobe, is the primary etiologic agent of liver abscesses in cattle. there are two subspecies; subsp. necrophorum and subsp. funduliforme, which differ in morphological, biochemical, molecular characteristics, and virulence. the subsp. necrophorum, which is more virulent, occurs more frequently in liver abscesses than the subsp. funduliforme. bacterial adhesion to the host cell surface is critical to the pathogenesis of several bacterial infections, a ... | 2015 | 25601800 |
| revisiting bovine pyometra--new insights into the disease using a culture-independent deep sequencing approach. | the bacteria present in the uterus during pyometra have previously been studied using bacteriological culturing. these studies identified fusobacterium necrophorum and trueperella pyogenes as the major contributors to the pathogenesis of pyometra. however, an increasing number of culture-independent studies have demonstrated that the bacterial diversity in most environments is underestimated in culture-based studies. consequently, fastidious pyometra-associated pathogens may have been overlooked ... | 2015 | 25550285 |
| microarray identification of bacterial species in peritonsillar abscesses. | peritonsillar abscess (pta) is the most common otorhinolaryngological infection, requiring management at the special healthcare level. the microbiological findings vary due to geographical, etiological, and methodological factors. this study aimed to identify the bacterial species of ptas by using a novel polymerase chain reaction (pcr)- and microarray-based assay, and to find causative cofactors among patients with different pathogens. we determined the bacterial findings of aspirates of pus pr ... | 2015 | 25547532 |
| fusobacterium necrophorum in a pediatric retropharyngeal abscess: a case report and review of the literature. | we present the case of a 17-year-old boy who developed a deep space neck infection following cervical trauma. he was initially managed conservatively with broad-spectrum antibiotics, but when he failed to improve clinically, he required surgical drainage. wound cultures grew fusobacterium necrophorum, an uncommon pathogen that can cause pediatric deep neck space infections, especially when it is not associated with lemierre syndrome. the prognosis for this infection is favorable when it is ident ... | 2014 | 25531849 |
| [life-threatening appendicitis caused by fusobacterium necrophorum]. | fusobacterium necrophorum is a well-known cause of lemierre's syndrome. recent studies suggest a causative association between f. necrophorum and acute appendicitis. we present a case of a 15-year-old previously healthy girl who presented with acute non-perforated appendicitis, intra-abdominal abscesses and thrombosis that led to omental necrosis. this resulted in a life-threatening septic shock with the need for prolonged intensive care. we suggest that f. necrophorum identified in pus from the ... | 2014 | 25497663 |
| a case of lemierre syndrome secondary to otitis media and mastoiditis. | lemierre's syndrome is a rare clinical condition that generally develops secondary to oropharyngeal infection caused by fusobacterium necrophorum, which is an anaerobic bacteria. a 62-year-old patient with diabetes mellitus presented with internal jugular vein and sigmoid sinus-transverse sinus thrombophlebitis, accompanying otitis media and mastoiditis that developed after an upper airway infection. interestingly, there were air bubbles in both the internal jugular vein and transverse sinus. va ... | 2014 | 25431696 |
| a case of pyogenic liver abscesses in a previously healthy adolescent man. | an 18-year-old, previously healthy man admitted with abdominal pain, high-grade fevers, nausea and emesis was found to have multiple hepatic abscesses. aspiration cultures grew fusobacterium necrophorum, a rare bacterium causing potentially fatal liver abscesses in humans. following sequential percutaneous drainages and narrowing of antibiotics, the patient was discharged on a 6-week antibiotic course and showed no signs of infection. a week after presentation it was discovered that he had exper ... | 2014 | 25389131 |
| lemierre's syndrome after evacuation of the uterus: a case report. | even minor surgical interventions can have serious complications. lemierre's syndrome is rare and to our best knowledge never before described after gynecological surgery; however, it should be considered in case of rapidly developing respiratory problems after even simple surgical procedures. | 2014 | 25356246 |
| septic internal jugular vein thrombosis caused by fusobacterium necrophorum and mediated by a broken needle. | the injection of drugs into the neck is unusual and thrombosis of the internal jugular vein can be a rare clinical presentation with a high risk for severe complications. we report a case of a 31-year-old male intravenous drug user presenting with fever, shortness of breath and right neck oedema. laboratory studies revealed elevated inflammation parameters. x-ray imaging revealed a broken syringe needle inside the soft tissues of the neck. computed tomography (ct) scans of the thorax and brain w ... | 2014 | 25290582 |
| adolescent with fever, hypotension, and respiratory distress. | | 2016 | 25115312 |
| lemierre's disease: a case with bilateral iliopsoas abscesses and a literature review. | lemierre's disease is characterized by sepsis, often with an oropharyngeal source, secondary septic emboli and internal jugular vein thrombosis (lancet 1:701-3, 1936. clin microbiol rev 20(4):622-59, 2007). septic emboli affecting many bodily sites have been reported, including the lungs, joints, bones, and brain. the case report describes an unusual case of lemierre's disease in a 64 year old gentleman causing profound sepsis, acute kidney injury, bilateral iliopsoas abscesses and a right hand ... | 2014 | 24904685 |
| the forgotten disease: bilateral lemierre's disease with mycotic aneurysm of the vertebral artery. | male, 25 final diagnosis: lemierre's disease symptoms: back pain • fever • headache • tachycardia • tachypnoe | 2014 | 24883173 |
| aerobic culture of anaerobic bacteria using antioxidants: a preliminary report. | antioxidants have been shown to help the growth of anaerobic bacteria. we were able to grow six anaerobe species (including fusobacterium necrophorum and ruminococcus gravus) and seven aerobic species all aerobically in schaedler agar tubes and agar plates with high doses of ascorbic acid and/or glutathione. this may deeply change strategies for culturing bacteria. | 2014 | 24820294 |
| antibody development to fusobacterium necrophorum in patients with peritonsillar abscess. | a polymicrobial mixture of aerobic and anaerobic bacteria is commonly recovered from peritonsillar abscess (pta) aspirates. previous studies have suggested a role for fusobacterium necrophorum (fn) in the development of pta. the purpose of the current study was to explore whether anti-fn antibodies were produced in patients with pta. we developed a novel immunofluorescence-based method to measure anti-fn antibody levels in acute and convalescent sera from 15 patients with pta and 47 patients wit ... | 2014 | 24810966 |
| draft genome sequence of fusobacterium necrophorum subsp. funduliforme bovine liver abscess isolate b35. | fusobacterium necrophorum is a gram-negative anaerobic bacterium that causes foot rot and liver abscesses in cattle. f. necrophorum subsp. necrophorum and the less virulent organism f. necrophorum subsp. funduliforme are recognized. we present here a draft genome sequence of the bovine liver abscess isolate f. necrophorum subsp. funduliforme strain b35, which affords a genomic perspective of virulence and bovine adaptation. | 2014 | 24786958 |
| [noma in a 4 year-old girl: a case report from chad]. | this case report describes a 4-year-old girl in chad with noma, also called cancrum oris. this acute gangrenous stomatitis has a combined morbidity-mortality rate that can reach 70%. it occurs worldwide but is most common in sub-saharan africa in children aged 2 to 16 years. its pathogenesis is uncertain, but several bacteria including fusobacterium necrophorum, prevotella intermedia and pseudomonas aeruginosa may be responsible for the development of noma, which develops over the oral lesions t ... | 2016 | 24736219 |
| pediatric otogenic sigmoid sinus thrombosis: 12-year experience. | otogenic sigmoid sinus thrombosis is a rare complication of acute otitis media. treatment remains controversial particularly regarding extent of surgical intervention. the aim of the study was to review the 12-year experience of a major medical center with the treatment of sigmoid sinus thrombosis in children. | 2014 | 24735608 |
| [throat ache ans swelling of the neck: first symptoms of lemierre's syndrome]. | lemierre's syndrome, a thrombophlebitis of the internal jugular vein, is a rare disorder, usually caused by the microorganism fusobacterium necrophorum. throat ache and swelling of the neck are often the first symptoms. without adequate treatment, lemierre's syndrome may result in thrombosis of the internal jugular vein and metastatic lung abscesses, with a mortality rate of 18%. on the basis of 2 cases, lemierre's syndrome is described here. in cases where lemierre's syndrome is suspected, hosp ... | 2014 | 24684132 |
| [sternal osteomyelitis and mediastinitis due to fusobacterium necrophorum]. | | 2014 | 24676245 |
| the significance and epidemiology of fusobacterium necrophorum in sore throats. | | 2014 | 24642207 |
| characterization of fusobacterium isolates from the respiratory tract of white-tailed deer (odocoileus virginianus). | a total of 23 clinical isolates of fusobacterium spp. were recovered at necropsy over a 2-year period from the respiratory tract of white-tailed deer (odocoileus virginianus). isolates were identified as fusobacterium varium (18/23), fusobacterium necrophorum subsp. funduliforme (3/23), and fusobacterium necrophorum subsp. necrophorum (2/23). using polymerase chain reaction-based detection of virulence genes, all f. necrophorum isolates were positive for the promoter region of the leukotoxin ope ... | 2014 | 24590666 |
| lemierre syndrome: not so forgotten! | lemierre syndrome is a rare and life-threatening illness. often referred to as "the forgotten disease," its incidence is reported to be as low as 1 in a million. the microorganism responsible for lemierre syndrome is typically fusobacterium necrophorum. the bacterium starts in the pharynx and peritonsillar tissue, then disseminates through lymphatic vessels. severe sepsis rapidly develops, as does the hallmark of this syndrome: septic thrombophlebitis of the internal jugular vein. this report de ... | 2014 | 24585168 |
| [updated guidelines for acute pharyngotonsillitis provides good support. but more research is needed on fusobacterium necrophorum]. | | 2014 | 24552008 |
| lemierre's syndrome presenting with septic shock. | lemierre's syndrome is a rare condition characterized by septic thrombophlebitis of the internal jugular vein and metastatic abscesses following oropharyngeal infection. though classically caused by fusobacterium necrophorum, a number of other causative organisms have been reported in literature. we report a case of lemierre's syndrome following parapharyngeal abscess due to staphylococcus aureus which progressed to septic shock. | 2013 | 24501493 |
| incidence and microbiology of peritonsillar abscess: the influence of season, age, and gender. | to explore the correlations among the incidence, microbiology, season, gender, and age in patients with peritonsillar abscess (pta) in order to identify risk factors for pta development. all patients with pta treated at private ent practices in aarhus county and in the ear-nose-throat departments at aarhus university hospital and randers hospital from january 2001 to december 2006 were included in the study. age- and gender-stratified population data for aarhus county for the same 6 years were o ... | 2014 | 24474247 |
| preliminary extraction and identification of the 44.5 kda outer membrane proteins isolated from bovine fusobacterium necrophorum (ab). | fusobacterium necrophorum (ab) in the pharynx, respiratory tract, female reproductive tract or urinary system is the causative agent of footrot and hepatic abscesses in animals and acute lemierre's syndrome in humans. current methods do not effectively protect animals and humans against f. necrophorum (ab). the outer membrane proteins (omp) of f. necrophorum (ab) can be used as new material to protect against the diseases induced by f. necrophorum (ab). the aim of this study was to extract omp a ... | 2013 | 24426142 |
| fusobacterium liver abscess. | fusobacterium is well characterized as an oropharyngeal pathogen that may induce a septic thrombophlebitis by direct extension of abscess into an adjacent neck vessel (lemierre's syndrome); its potential for visceral abscess formation, however, remains under-recognized. a 65-year-old man with a recent history of multiple rim-enhancing liver lesions presented to the emergency room with fever and abdominal pain. based on interval increase in the size of the lesions, abscess was suspected. a liver ... | 2013 | 24348321 |
| fusobacterium species infections: clinical spectrum and outcomes at a district general hospital. | fusobacterium species infections are rare. recently, however, this potentially deadly pathogen has been attracting interest, and efforts are being made to characterise its epidemiology and clinical spectrum of disease. the aim of our study is to provide further evidence towards this cause, in what is, to date, the largest study of its kind from the uk. | 2014 | 24326987 |
| gradenigo's syndrome: is fusobacterium different? two cases and review of the literature. | gradenigo's syndrome is a rare but life threatening complication of acute otitis media (aom), which includes a classic triad of otitis media, deep facial pain and ipsilateral abducens nerve paralysis. the incidence of fusobacterium necrophorum infections has increased in recent years. we describe two cases of gradenigo's syndrome caused by f. necrophorum. additional four cases were identified in a review of the literature. gradenigo's syndrome as well as other neurologic complications should be ... | 2014 | 24315216 |
| arterial ischemic stroke as a complication to disseminated infection with fusobacterium necrophorum. | lemierre syndrome (ls) is a rare complication of oropharyngeal and odontogenic infections in otherwise healthy young individuals. it is characterized by septic internal jugular vein thrombophlebitis and disseminated metastatic abscesses. cerebral arterial ischemic stroke is rarely seen in ls. the authors present a 14-year-old, previously healthy girl, who developed cerebral arterial infarction following acute tonsillitis and abscess formations due to fusobacterium necrophorum. | 2014 | 24227208 |
| first case of fusobacterium necrophorum endocarditis to have presented after the 2nd decade of life. | fusobacterium necrophorum, an obligate, anaerobic, filamentous, gram-negative rod, is thought to be a normal inhabitant of the mucous membranes in human beings. fusobacterium species have been implicated in cases of lemierre syndrome and other pathologic conditions. their reported association with infective endocarditis is extremely rare. we describe the case of a previously healthy 34-year-old man who emergently presented with flu-like symptoms and dyspnea on exertion. he had recently undergone ... | 2013 | 24082377 |
| endoscopic sphenoid sinus drainage in lemierre syndrome. | lemierre syndrome is a rare condition arising from an invasive oropharyngeal infection, which leads to septic thrombophlebitis of the internal jugular vein and multi-organ septic embolization. intracranial complications are rare but serious, including subdural empyema, cavernous sinus thrombosis, and internal carotid artery aneurysms. we report a patient with lemierre syndrome with multiple intracranial complications despite aggressive antimicrobial therapy. the patient eventually required trans ... | 2014 | 24060623 |