Publications

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the smoking gun. 20102857863
connective tissue responses in blacks in relation to disease: further observations.additional information is presented in support of the hypothesis (polednak: am. j. phys. anthropol. 41:49-58, 1974) that in some black populations certain connective-tissue responses, which are involved in protection against infection and repair after injury, also may predispose to specific chronic diseases. these diseases include some autoimmune disorders (i.e., systemic lupus erythematosus, sarcoidosis, and scleroderma) and various benign and malignant tumors involving connective-tissue cells. ...20103322033
eftu provides an internal kinetic standard for translational accuracy. 20103072707
pharmacokinetics of postoperative intravenous indomethacin in children.the disposition of indomethacin was studied in children aged one to four years. indomethacin 0.35 mg/kg was administered as an intravenous infusion during 15 min. venous blood samples were collected until 24 hr after infusion. serum indomethacin was determined with gas chromatography. using a non-linear regression analysis, the individual data were fitted by a two-compartment open mammillary model with central elimination. calculated pharmacokinetic parameters were (mean +/- sd); alpha half-life ...20102813287
mixed hematopoietic chimerism following bone marrow transplantation for hematologic malignancies.twenty-nine of 172 patients (17%) who received an allogeneic bone marrow transplant (bmt) from histocompatible sibling donors for hematologic malignancies were mixed hematopoietic chimeras; ie, they had a mixture of donor and host hematopoietic or lymphohematopoietic cells at greater than or equal to 14 days after transplantation. twenty-four of the 29 mixed chimeras (83%) have remained in continuous complete remission for up to 116 months (greater than 9 years) following bmt. four of the 29 pat ...20113311201
pediatric emergency care: a survey of michigan emergency departments. 20113250954
clinical alternative. formulating your own concept of occlusion. 20113163180
[l.v. gromashevskiÄ­'s paradigm]. 20113321779
[development of l.v. gromashevskiÄ­'s theory within the socio-ecological concept of the epidemiological process]. 20113321777
the microbiologic etiology of periodontal disease. 20113087693
the contribution of large granular lymphocytes to b cell activation and differentiation after t-cell-depleted allogeneic bone marrow transplantation.immunoglobulin and specific antibody levels are well maintained in the recipients of t-cell-depleted allogeneic bone marrow transplants (bmt), even though up to 99% of mature t cells are removed from the donor graft. for 3-8 weeks after the procedure, natural killer (nk) cells with an activated pattern of target cell killing have been shown to circulate in the recipient. this study investigates whether these recipient nk cells spontaneously secrete lymphokines that modulate b cell function in a ...20113092411
[an experience of a nursing instructor as a patient. 8. suffering imposed on the patient (2): problems related to treatment]. 20113204763
[urinary hydrogen ion concentration as one of the pathogenetic factors of urinary calculi]. 20123445570
[immunologic abnormality of collagen diseases, with special reference to rheumatoid arthritis]. 20123388147
bowenoid papulosis of the penis: successful management with neodymium:yag laser.bowenoid papulosis of the penis is a recently described entity that clinically resembles benign verruca-like papular lesions but, histologically, it is identical to carcinoma in situ, bowen's disease or erythroplasia of queyrat. although a few cases of spontaneous regression of bowenoid papulosis in men have been reported, conservative therapy, consisting of topical 5-fluorouracil, electrodissection or excision, is recommended. with these treatment modalities recurrences are not uncommon. we rep ...20123373609
[differential diagnosis of gunshot wounds in shots from a smoothbore gun with the usual equipment and one using a wad-container]. 20123433312
[use of the exercise test to identify high-risk patients. correlation with coronariography]. 20124001510
the role of intravenous digital subtraction angiography as an adjunct to computed tomography in the preoperative assessment of patients with abdominal aortic aneurysm.the purpose of this article is to determine the role of intravenous digital subtraction angiography (iv-dsa) as an adjunct to computed tomography (ct) in the preoperative evaluation of patients with abdominal aortic aneurysm. sixty-six patients underwent iv-dsa as well as ct during a 2-year period. sixty-four of the 66 patients underwent abdominal aortic aneurysm repair. the results of the 66 patients were analyzed to assess what additional information was obtained by iv-dsa concerning aneurysm ...20123298699
[ectopic parathyroid adenoma disclosed by cortical blindness and hypercalcemic encephalopathy]. 20123269289
ventricular arrhythmias.sudden cardiac death claims thousands of canadians annually. ventricular tachycardia and fibrillation account for up to 85% of these deaths. identifying the patients at risk remains a major challenge. those who have recurrent ventricular tachycardia or have been resuscitated from ventricular fibrillation are generally considered to be at highest risk. although ventricular premature beats in the absence of previous ventricular tachycardia or fibrillation are not helpful in identifying such patien ...20123284626
[treatment of chronic bursitis with fistula by a cryogenic method]. 20123247124
[endoscopic polypectomy in pediatrics. nursing care]. 20133854901
effect of seat belts on injuries to front and rear seat passengers.data on 2520 occupants of cars involved in accidents were analysed in relation to injury and the severity of the crash to investigate the effect of rear seat passengers on injury to restrained and unrestrained front seat occupants and vice versa. unrestrained front seat occupants showed a higher incidence of serious injury when there were rear seat passengers. the presence of a rear seat passenger did not affect significantly the overall incidence of injury among restrained front seat occupants ...20133924192
[magnesium and calcium metabolism in peptic ulcer patients]. 20133798889
a case of hypertension due to unilateral hydronephrosis in a child.a case of hypertension secondary to unilateral hydronephrosis due to congenital obstruction of ureteropelvic junction in a 6-year-old boy is reported. preoperatively, the plasma renin activity (pra) in the peripheral vein and in the affected kidney was elevated. blood pressure decreased significantly following administration of converting enzyme inhibitor. after nephrectomy, peripheral vein pra and blood pressure returned to normal, despite withdrawal of antihypertensive medication and sodium re ...20133780805
ruptured abdominal aortic aneurysm in a 24-year-old african woman. unusual presentation--unknown aetiology.24-year-old black female presenting with progressive paralysis of the left lower limb. the clinical examination and investigations describe an extensive retroperitoneal mass. an exploratory laparotomy reveals a ruptured saccular infrarenal aortic aneurysm, a narrowing of the distal aorta and a complete obstruction of the left common iliac artery. the aneurysm was resected, an aortoiliac bypass and femorofemoral crossover bypass were performed, with success. the clinical presentation of this rupt ...20133766024
multiple flexor tendon xanthomas and contractures in the hands of a child with familial hypercholesterolemia.a 6-year-old girl with familial hypercholesterolemia had flexion contractures of the fingers due to tendon and joint xanthomas. this unique problem was corrected by the combination of local hand surgery and a portacaval shunt.20133722777
hyperphosphaturia associated with hypercalciuria in renal calcium stone patients. 20133691118
utility of the routine electrocardiogram before surgery and on general hospital admission. critical review and new guidelines.no consensus has been reached regarding the need for a routine 12-lead electrocardiogram (ecg) preoperatively or on general admission in adult patients. critical review of relevant studies reveals important weaknesses and gaps in the data needed to formulate definitive recommendations. available data, however, do not support the necessity for obtaining a baseline or screening ecg in all adult patients before surgery involving general or regional anesthesia or on hospital admission for other indi ...20133752762
[clinical significance of atrial fibrillation]. 20133647493
systemic absorption of adrenaline after aerosol, eye-drop and subcutaneous administration to healthy volunteers.adrenaline is the drug of choice for management of the anaphylactic reaction. the objective of this study was to compare systemic absorption of adrenaline after administration by different routes to healthy volunteers. ten puffs (1.5 mg as adrenaline base) with 10-15 s intervals between them followed 2 h later by 20 puffs (3 mg) of adrenaline from a pressurized aerosol (medihaler-epi, 3m riker, 14.0 mg/ml adrenaline acid tartrate) were sprayed into the cheek pouch or inhaled through the mouth or ...20133592145
implantable myoelectric control system with sensory feedback. 20133974327
the transcapillary exchange of sodium fluorescein in ischaemic limbs measured by fluorescein flowmetry.the transcapillary exchange of sodium fluorescein in the skin of 36 extremities (19 patients) with arterial occlusive disease was measured using two different ways of analysing the tissue fluorescence, fluorescein flowmetry (ff) and dynamic fluorescein angiography (fa). 7 mg sodium fluorescein/kg body weight was given intravenously. with ff, the transcapillary exchange of sodium fluorescein is expressed in arbitrary units as a fluorescence index. with fa, the time interval from the bolus injecti ...20133568585
cancer of the breast in women born in southern italy and who migrated to the city of torino.individual demographic data of 459 women living in torino with incident breast cancer diagnosed in 1979 were compared with those of a random sample of 1800 women drawn from the list of residents in the same city. among women aged 25-44 and 45+ years, age-adjusted odds ratios for birth in southern italy were respectively 1.3 (95% cl, 0.1-2.1) and 0.7 (95% cl, 0.5-0.9). in women aged 45+ years, odds ratios increased with length of residence in torino.20133603717
graduate medical education: who will pay how much for what? 20133541729
[cancer of the ethmoid sinus and socio-occupational categories]. 20144257530
[therapy with chlorambucil in progressive chronic polyarthritis]. 20144187786
electroencephalograms in children suffering from migraine. 20144183402
[distribution of bacterioplankton in the sea of azov]. 20144261526
[scid proteinase and phosphatase activity of the blood serum in patients with osteoarthritis deformans]. 20144155566
the timing of sensitisation and its relevance to the prevention of rh-haemolytic disease. 20144178383
cineangiocardiographic observation of a right ventricular string. 20144080579
effect of temperature on rheological properties of four dental restorative materials. 20144519057
auditory evoked potentials during alterations in "attention". 20144165615
pulmonary vascular overreactivity in systemic hypertension. a pathophysiological link between the greater and the lesser circulation.this study was undertaken to test whether the emphasized systemic vasomotion during sympathetic activation in hypertension is shared by the pulmonary circulation. to this end, 10 normotensive and 29 primary hypertensive subjects were investigated during adrenergic stimulation by mental arithmetic and cold pressor test. both stimuli induced a systemic pressor reaction in both groups, which was mediated through an increase in cardiac output and a mild reduction in vascular resistance during arithm ...20144077227
erythromelalgia without thrombocythemia. 20144026098
should we worry about gastric cancer in duodenal ulcer patients?in three patients with active duodenal ulcer, carcinoma of the stomach was detected early during routine endoscopic examination. in all patients subtotal gastrectomy was performed, and pathological examination of the resected stomach revealed carcinoma confined to the mucosa. we review evidence for and against any association between gastric carcinoma and peptic ulcer disease.20144020082
estimating gestational age from biparietal diameter: a simple formula. 20143944845
diathermy-induced loss of ddd pacemaker identity. 20144015251
[kidney transplant in patients with polycystic nephropathy]. 20143914713
reactivation kinetics of diethylphosphoryl acetylcholine esterase.the kinetics of reactivation of diethylphosphorylated acetylcholine esterase by pyridine-2-aldoxime methochloride has been studied using the approach of following the course of the hydrolysis of acetylcholine during the reactivation of the phosphorylated enzyme by the reactivator [tsou, c.-l. (1965) acta biochem. biophys. sin. 5, 398-417]. equations are derived based on the scheme of the formation of a complex between the phosphorylated enzyme and the reactivator and the rate of dissociation of ...20144029145
[preleukemic state with symptoms of aplastic anemia]. 20154674957
[noble's operation for acute adhesional intestinal obstruction]. 20154658071
[suicide and attempted suicide. trends, statistics, prevention, help]. 20154595018
the definition of the hospital catchment area and its population as a denominator for the evaluation of hospital returns in developing countries. 20154774785
the prognosis of untreated and of treated hypertension and advantages of early treatment. 20154559696
[separation of corrinoids by elution chromatography on columns of the non-polar adsorbent amberlite xad-2]. 20154689609
joseph john brownlee. 20154568851
cytosol androgen receptor from kidney of normal and testicular feminized (tfm) mice. 20154369902
assessment of biological age. methodological study in two finnish populations. 20154367143
[an impressive death]. 20154487539
[factors affecting the function of the gall bladder and biliary ducts. the physiology of gall bladder filling (author's transl)]. 20154371677
enzymic cleavage of post-proline peptide bonds: degradation of arginine-vasopressin and angiotensin ii. 20154344264
retinal image: larger and more illuminous for a nocturnal than for a diurnal lizard. 20154706357
[ambulatory chemotherapy of pulmonary tuberculosis with special reference to strictly supervised intermittent drug dosage]. 20154699465
[glucagon and its effect on the gastrointestinal tract]. 20154365192
microchemical assays of glucose and glucose-6-phosphate in mammalian pancreatic beta-cells. 20154301817
drug use, drug-use attitudes, and the authoritarianism-rebellion dimension. 20165088031
[iatrogenic accident. trial of a case involving the accidental death of a blood donor at the chiba university hospital]. 20164994305
[case of the lumbar disc herniating into the subdural space]. 20165106825
[heteroplastic transplants with kiel bone]. 20164912781
effect of dipyridamole on the incidence of arterial emboli after cardiac valve replacement. 20164893436
[the hypoplastic thumb]. 20164874597
[epidemiology of histiocytic sarcomatosis of hemopoietic tissues. clinico-statistical considerations and remarks on predisposing, premorbid and morbid conditions in 545 cases in certain regions of lazio]. 20164861511
cross-cultural evaluation of schneider's first-rank symptoms of schizophrenia: a report from the international pilot study of schizophrenia. 20164827800
sampling issues in family studies of schizophrenia. 20164809929
[compulsory continuing medical education?]. 20164778859
[editorial: asplenia]. 20164776005
gas chromatographic-mass spectrometric studies of tricyclic compounds used in psychiatry. 20164765105
ectrodactyly, ectodermal dysplasia, and clefting syndrome. 20164759861
metabolism of 2,4-dichlorophenoxyacetic acid. v. identification of metabolites in soybean callus tissue cultures. 20164736996
[classification of intersexuality]. 20164906763
ultrastructure manifestations of g m1 and g m2 gangliosidosis in fetal tissues. 20164701390
saliva, salivary gland, and hemolymph collection from ixodes scapularis ticks.ticks are found worldwide and afflict humans with many tick-borne illnesses. ticks are vectors for pathogens that cause lyme disease and tick-borne relapsing fever (borrelia spp.), rocky mountain spotted fever (rickettsia rickettsii), ehrlichiosis (ehrlichia chaffeensis and e. equi), anaplasmosis (anaplasma phagocytophilum), encephalitis (tick-borne encephalitis virus), babesiosis (babesia spp.), colorado tick fever (coltivirus), and tularemia (francisella tularensis) (1-8). to be properly trans ...201222371172
natural blood feeding and temperature shift modulate the global transcriptional profile of rickettsia rickettsii infecting its tick vector.rickettsia rickettsii is an obligate intracellular tick-borne bacterium that causes rocky mountain spotted fever (rmsf), the most lethal spotted fever rickettsiosis. when an infected starving tick begins blood feeding from a vertebrate host, r. rickettsii is exposed to a temperature elevation and to components in the blood meal. these two environmental stimuli have been previously associated with the reactivation of rickettsial virulence in ticks, but the factors responsible for this phenotype c ...201324155949
assessment of real-time pcr assay for detection of rickettsia spp. and rickettsia rickettsii in banked clinical samples.two novel real-time pcr assays were developed for the detection of rickettsia spp. one assay detects all tested rickettsia spp.; the other is specific for rickettsia rickettsii. evaluation using dna from human blood and tissue samples showed both assays to be more sensitive than nested pcr assays currently in use at the cdc.201323135935
unusual bacterial infections and the pleura.rickettsiosis, q fever, tularemia, and anthrax are all bacterial diseases that can affect the pleura. rocky mountain spotted fever (rmsf) and mediterranean spotted fever (msf) are caused by rickettsia rickettsii and rickettsia conorii, respectively. pleural fluid from a patient with msf had a neutrophil-predominant exudate. coxiellaburnetii is the causative agent of q fever. of the two cases described in the literature, one was an exudate with a marked eosinophilia while the other case was a tra ...201222977649
detection of rickettsia rickettsii, rickettsia parkeri, and rickettsia akari in skin biopsy specimens using a multiplex real-time polymerase chain reaction assay.rickettsia rickettsii, rickettsia parkeri, and rickettsia akari are the most common causes of spotted fever group rickettsioses indigenous to the united states. infected patients characteristically present with a maculopapular rash, often accompanied by an inoculation eschar. skin biopsy specimens are often obtained from these lesions for diagnostic evaluation. however, a species-specific diagnosis is achieved infrequently from pathologic specimens because immunohistochemical stains do not diffe ...201424829214
immunoproteomic profiling of rickettsia parkeri and rickettsia amblyommii.rickettsia parkeri is an amblyomma-associated, spotted fever group rickettsia species that causes an eschar-associated, febrile illness in multiple countries throughout the western hemisphere. many other rickettsial species of known or uncertain pathogenicity have been detected in amblyomma spp. ticks in the americas, including rickettsia amblyommii, "candidatus rickettsia andeanae" and rickettsia rickettsii. in this study, we utilized an immunoproteomic approach to compare antigenic profiles of ...201526234571
comparative genomics and transcriptomics of trait-gene association.the order rickettsiales includes important tick-borne pathogens, from rickettsia rickettsii, which causes rocky mountain spotted fever, to anaplasma marginale, the most prevalent vector-borne pathogen of cattle. although most pathogens in this order are transmitted by arthropod vectors, little is known about the microbial determinants of transmission. a. marginale provides unique tools for studying the determinants of transmission, with multiple strain sequences available that display distinct a ...201223181781
differences in intracellular fate of two spotted fever group rickettsia in macrophage-like cells.spotted fever group (sfg) rickettsiae are recognized as important agents of human tick-borne diseases worldwide, such as mediterranean spotted fever (rickettsia conorii) and rocky mountain spotted fever (rickettsia rickettsii). recent studies in several animal models have provided evidence of non-endothelial parasitism by pathogenic sfg rickettsia species, suggesting that the interaction of rickettsiae with cells other than the endothelium may play an important role in pathogenesis of rickettsia ...201627525249
a fatal urban case of rocky mountain spotted fever presenting an eschar in san jose, costa rica.this study reports the first urban human case of rocky mountain spotted fever caused by rickettsia rickettsii, in costa rica. an 8-year-old female who died at the national children's hospital 4 days after her admission, and an important and significant observation was the presence of an "eschar" (tache noire), which is typical in some rickettsial infections but not frequent in rocky mountain spotted fever cases.201222855769
chloroform-methanol residue of coxiella burnetii markedly potentiated the specific immunoprotection elicited by a recombinant protein fragment rompb-4 derived from outer membrane protein b of rickettsia rickettsii in c3h/hen mice.the obligate intracellular bacteria, rickettsia rickettsii and coxiella burnetii, are the potential agents of bio-warfare/bio-terrorism. here c3h/hen mice were immunized with a recombinant protein fragment romp-4 derived from outer membrane protein b, a major protective antigen of r. rickettsii, combined with chloroform-methanol residue (cmr) extracted from phase i c. burnetii organisms, a safer q fever vaccine. these immunized mice had significantly higher levels of igg1 and igg2a to rompb-4 an ...201525909586
failure of a heterologous recombinant sca5/ompb protein-based vaccine to elicit effective protective immunity against rickettsia rickettsii infections in c3h/hen mice.spotted fever group (sfg) rickettsial species are obligate intracellular tick-borne pathogens that are responsible for important human diseases. previous reports have demonstrated the feasibility of using recombinant surface cell antigen sca5/ompb to elicit protective immunity against homologous challenges using murine models of mediterranean spotted fever and rocky mountain spotted fever. in addition, the feasibility of generating cross-protective immunity against related rickettsial species ha ...201526519448
identification of novel surface-exposed proteins of rickettsia rickettsii by affinity purification and proteomics.rickettsia rickettsii, the causative agent of rocky mountain spotted fever, is the most pathogenic member among rickettsia spp. surface-exposed proteins (seps) of r. rickettsii may play important roles in its pathogenesis or immunity. in this study, r. rickettsii organisms were surface-labeled with sulfo-nhs-ss-biotin and the labeled proteins were affinity-purified with streptavidin. the isolated proteins were separated by two-dimensional electrophoresis, and 10 proteins were identified among 23 ...201424950252
synanthropic mammals as potential hosts of tick-borne pathogens in panama.synanthropic wild mammals can be important hosts for many vector-borne zoonotic pathogens. the aim of this study was determine the exposure of synanthropic mammals to two types of tick-borne pathogens in panama, spotted fever group rickettsia (sfgr) and borrelia relapsing fever (rf) spirochetes. one hundred and thirty-one wild mammals were evaluated, including two gray foxes, two crab-eating foxes (from zoos), four coyotes, 62 opossum and 63 spiny rats captured close to rural towns. to evaluate ...201728060928
geographical distribution of amblyomma cajennense (sensu lato) ticks (parasitiformes: ixodidae) in brazil, with description of the nymph of a. cajennense (sensu stricto).until recently, amblyomma cajennense (fabricius, 1787) was considered to represent a single tick species in the new world. recent studies have split this taxon into six species. while the a. cajennense species complex or a. cajennense (sensu lato) (s.l.) is currently represented by two species in brazil, a. cajennense (sensu stricto) (s.s.) and amblyomma sculptum berlese, 1888, their geographical distribution is poorly known.201627036324
ticks and rickettsiae from wildlife in belize, central america.the agents of spotted fevers in latin america are rickettsia rickettsii, r. parkeri, rickettsia sp. strain atlantic rainforest, and r. massiliae. in continental central america, r. rickettsii remains the only known pathogenic tick-borne rickettsia. in the present study, ticks were collected from wild mammals in natural areas of belize. besides providing new data of ticks from belize, we investigated rickettsial infection in some of these ticks. our results provide ticks harboring rickettsial age ...201626831147
experimental infection of horses with rickettsia rickettsii.rickettsia rickettsii is vectored by ticks, and some vertebrate hosts can be sources of infection to ticks during bacteremic periods. in brazil, the main vector for r. rickettsii is the tick amblyomma sculptum, a member of the a. cajennense complex. horses, in turn, are one of the major hosts for a. sculptum. in this study, horses experimentally infected with r. rickettsii were assessed for clinical changes and their capability to transmit the infection to a. sculptum ticks.201627624315
high seroprevalence for rickettsia rickettsii in equines suggests risk of human infection in silent areas for the brazilian spotted fever.equines play a role in the epidemiology of brazilian spotted fever (bsf) since they are a primary host for the tick amblyomma sculptum. we studied the seroprevalence for three species of rickettsia in equines in four endemic (with human cases) and in four non-endemic areas (no human cases) in the piracicaba river basin, são paulo, brazil. a serological survey of 504 equines was performed: around 63 animals were sampled in each area and tested through indirect immunofluorescence assay for r. rick ...201627064788
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