| analysis of the integrin β3 receptor for pathogenic orthohantaviruses in rodent host species. | host reservoir specificity of pathogens is complex and may depend on receptor variability. for pathogenic orthohantaviruses, integrin β3 had been previously identified as entry receptor and the presence of aspartic acid residue at position 39 (d39) in human integrin β3 was described to be a prerequisite for infection of primate cells with hantaan virus (htnv). however, the role of integrin β3 in orthohantavirus infection of host animals is not completely understood. therefore, we analyzed the nu ... | 2019 | 31054291 |
| the competition between immatures of ixodes ricinus and dermacentor reticulatus (ixodida: ixodidae) ticks for rodent hosts. | the numbers of ixodes ricinus (l.) and dermacentor reticulatus (fabricius) larvae and nymphs attached to small mammals are influenced by interspecific competition. the present study analyses data collected over several years in two study areas: kosewo górne (mazurian district, n poland; between july 1997 and july 2009) and białowieża primeval forest (e poland; in july 2007). in total, 975 ticks were collected from striped field mice (apodemus agrarius), yellow-necked mice (a. flavicollis), bank ... | 2019 | 30346558 |
| evidence for co-invasion events: different chigger species (actinotrichida, trombidioidea: trombiculidae) share a host. | cases of co-invasion of various chigger species parasitizing murids and cricetids in various habitats were analysed using morphological and molecular approaches. here we provide evidence for 25 new cases of co-parasitism of chigger mites on rodent hosts (myodes glareolus, apodemus flavicollis, apodemus agrarius) accounting for 8.6% of all host-parasite associations observed in this study. the results confirm higher incidence of co-parasitism in vertebrate-associated parasitengona mites compared ... | 2018 | 30206798 |
| intraspecific variation of body size in fleas: effects of host sex and flea phenology. | we investigated the effects of host sex and flea phenology (estimated as periods of high versus low abundance) on individual body size in four fleas of small mammals. amalaraeus penicilliger and ctenophthalmus uncinatus are ectoparasites of the bank vole myodes glareolus, whereas doratopsylla dasycnema and palaeopsylla soricis are ectoparasites of the common shrew sorex araneus. we found significant effects of host sex and phenology on the body size of all flea species, although there was no gen ... | 2020 | 32888066 |
| the content of dioxins and furans in soils, bottom sediments of water bodies, and tissues of small mammals near the landfill site with municipal solid wastes (moscow, russia). | for the first time, the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdd/fs) were characterized in the tissues of wild small mammals living in contaminated sites near a municipal solid waste landfill (moscow, russia). the ural field mice sylvaemus uralensis, the bank voles clethrionomys glareolus, and the common shrews sorex araneus were trapped at 1- and 5-km distances from the landfield "salariyevo." high-resolution chromatography-mass spectrometry was used to measure the le ... | 2018 | 30121772 |
| generalist eimeria species in rodents: multilocus analyses indicate inadequate resolution of established markers. | intracellular parasites of the genus eimeria are described as tissue/host-specific. phylogenetic classification of rodent eimeria suggested that some species have a broader host range than previously assumed. we explore whether eimeria spp. infecting house mice are misclassified by the most widely used molecular markers due to a lack of resolution, or whether, instead, these parasite species are indeed infecting multiple host species.with the commonly used markers (18s/coi), we recovered monophy ... | 2020 | 32076521 |
| patchy occurrence of cowpox virus in voles from germany. | cowpox virus (cpxv), genus orthopoxvirus, family poxviridae, is a zoonotic pathogen in eurasian wild rodents. high seroprevalences have been reported previously for vole and murine species in europe. in contrast, viral dna was only rarely detected, and very few reservoir-derived cpxv isolates exist. in this study, cpxv dna and cpxv-reactive antibodies were monitored in wild small mammals for 5 years in four german federal states. screening of liver tissues of 3966 animals by cpxv real-time pcr ( ... | 2020 | 32013767 |
| molecular detection and characterization of the first cowpox virus isolate derived from a bank vole. | cowpox virus (cpxv) is a zoonotic orthopoxvirus (opv) that infects a wide range of mammals. cpxv-specific dna and antibodies were detected in different vole species, such as common voles (microtus arvalis) and bank voles (myodes glareolus). therefore, voles are the putative main reservoir host of cpxv. however, cpxv was up to now only isolated from common voles. here we report the detection and isolation of a bank vole-derived cpxv strain (germygek 938/17) resulting from a large-scale screening ... | 2019 | 31752129 |
| parasites in brains of wild rodents (arvicolinae and murinae) in the city of leipzig, germany. | small rodents serve as intermediate or paratenic hosts for a variety of parasites and may participate in the transmission of these parasites into synanthropic cycles. parasites with neuroinvasive stages, such as toxoplasma gondii or toxocara canis, can cause detrimental damage in the brain of intermediate or paratenic hosts. therefore, the occurrence of neuroinvasive parasite stages was evaluated in brains of wild rodents captured in the city of leipzig, germany. in addition, a few specimens fro ... | 2019 | 31667084 |
| inheritance of the acoustic signal parameters in interspecific hybrids of the bank (myodes glareolus) and the tien shan (m. centralis) voles. | the continuity of behavioral responses in the traits of offspring can be interpreted ambiguously because animal behavior can be transmitted from generation to generation genetically or can be trained. inheritance of the sound signals characteristics in the absence of directional selection is of particular interest, and that was the purpose of the present work. | 2019 | 30813911 |
| borrelia spp. in small mammals in romania. | small mammals play an important role in the life-cycle of ticks and are reservoirs for several zoonotic pathogens. the aim of this study was to provide epidemiological data regarding the presence of borrelia spp. in tissues of small mammals from romania. | 2019 | 31551069 |
| relationship between heavy metal accumulation and histological alterations in voles from alpine and forest habitats of the west carpathians. | the interaction between toxic heavy metals and bio-elements in internal organs and femoral bones and their potential impacts on bone structural properties and renal histopathological changes in bank voles and snow voles were investigated. our results reveal that heavy metals hg and pb accumulate more in femoral bones of alpine habitats than forests. in snow voles, the parameters of the primary osteons' vascular canals (length, average perimeter and area) simultaneously decreased with an increase ... | 2020 | 32562226 |
| revealing mechanisms of mating plug function under sexual selection. | mating plugs are produced by many sexually reproducing animals and are hypothesized to promote male fertilization success under promiscuous mating. however, tests of this hypothesis have been constrained by an inability to discriminate ejaculates of different males in direct competition. here, we use stable isotope labeling in vivo and proteomics to achieve this in a promiscuous rodent, myodes glareolus we show that, although the first male's plug is usually dislodged, it can be retained through ... | 2020 | 33077605 |
| two hundred and fifty-four metagenome-assembled bacterial genomes from the bank vole gut microbiota. | vertebrate gut microbiota provide many essential services to their host. to better understand the diversity of such services provided by gut microbiota in wild rodents, we assembled metagenome shotgun sequence data from a small mammal, the bank vole myodes glareolus (rodentia, cricetidae). we were able to identify 254 metagenome assembled genomes (mags) that were at least 50% (n = 133 mags), 80% (n = 77 mags) or 95% (n = 44 mags) complete. as typical for a rodent gut microbiota, these mags are d ... | 2020 | 32968071 |
| implication of membrane androgen receptor (zip9) in cell senescence in regressed testes of the bank vole. | here, we studied the impact of exposure to short daylight conditions on the expression of senescence marker (p16), membrane androgen receptor (zip9) and extracellular signal-regulated kinase (erk 1/2), as well as cyclic amp (camp) and testosterone levels in the testes of mature bank voles. animals were assigned to groups based on an analysis of testis diameter, weight, seminiferous tubule diameter and the interstitial tissue area: group 1, not fully regressed (the highest parameters); group 2 (m ... | 2020 | 32961828 |
| the utility of bank voles for studying prion disease. | the transmission of prions between species is typically an inefficient process due to the species barrier, which represents incompatibility between prion seed and substrate molecules. bank voles (myodes glareolus) are an exception to this rule, as they are susceptible to a diverse range of prion strains from many different animal species. in particular, bank voles can be efficiently infected with most types of human prions and have played a critical role in validating variably protease-sensitive ... | 2020 | 32958232 |
| two distinct prions in fatal familial insomnia and its sporadic form. | fatal familial insomnia is a genetic prion disease, which is associated with the aspartic acid to asparagine substitution at codon 178 of the prion protein gene. although the hallmark pathological feature is thalamic and olivary degeneration, there is a patient with an atypical fatal familial insomnia without the hallmark feature. the cause of the pathological variability is unclear. we analysed a japanese fatal familial insomnia kindred and compared one atypical clinicopathological fatal famili ... | 2019 | 32954274 |
| do bank voles (myodes glareolus) trapped in live and lethal traps show differences in tick burden? | in studies assessing tick abundance, the use of live traps to capture and euthanize rodent hosts is a commonly used method to determine their burden. however, captive animals can experience debilitating or fatal capture stress as a result prior to collection. an alternative method is the use of lethal traps, but this can potentially lead to tick drop-off between the time of capture and collection. in this study, in order to determine whether subjecting animals to capture stress is inevitable, we ... | 2020 | 32941509 |
| applying the anna karenina principle for wild animal gut microbiota: temporal stability of the bank vole gut microbiota in a disturbed environment. | gut microbiota play an important role in host health. yet, the drivers and patterns of microbiota imbalance (dysbiosis) in wild animals remain largely unexplored. one hypothesised outcome of stress on animal microbiomes is a destabilised microbial community that is characterised by an increase in inter-individual differences compared with microbiomes of healthy animals, which are expected to be (a) temporally stable and (b) relatively similar among individuals. this set of predictions for respon ... | 2020 | 32939769 |
| detection and genetic characterization of puumala orthohantavirus s-segment in areas of france non-endemic for nephropathia epidemica. | puumala virus (puuv) in europe causes nephropathia epidemica (ne), a mild form of hemorrhagic fever with renal syndrome (hfrs). the incidence of ne is highly heterogeneous spatially, whereas the geographic distribution of the wild reservoir of puuv, the bank vole, is essentially homogeneous. our understanding of the processes driving this heterogeneity remains incomplete due to gaps in knowledge. little is known about the current distribution and genetic variation of puuv in the areas outside th ... | 2020 | 32882953 |
| effectiveness of antivirals in a type 1 diabetes model and the move toward human trials. | a picornavirus (ljungan virus [lv]) originally found in bank voles has been associated with type 1 diabetes (t1d) in its wild rodent reservoir, but also associated with t1d in a laboratory rat model for the disease, the diabetes prone (dp) bio breeding (bb) rat. successful treatment of diabetes in this rat model, using experimental antiviral compounds directed against picornavirus, has been reported. in the present study we show significant clinical response in dp-bb rats using antiviral compoun ... | 2020 | 32758075 |
| the effect of chronic low-dose environmental radiation on organ mass of bank voles in the chernobyl exclusion zone. | animals are exposed to environmental ionizing radiation (ir) externally through proximity to contaminated soil and internally through ingestion and inhalation of radionuclides. internal organs can respond to radioactive contamination through physiological stress. chronic stress can compromise the size of physiologically active organs, but studies on wild mammal populations are scarce. the effects of environmental ir contamination on organ masses were studied by using a wild rodent inhabiting the ... | 2020 | 32658635 |
| prevalence of the puumala orthohantavirus strains in the pre-kama area of the republic of tatarstan, russia. | puumala orthohantavirus (puuv) causes nephropathia epidemica (ne), a mild form of hemorrhagic fever with renal syndrome (hfrs) commonly diagnosed in europe. the majority of hfrs cases in the european part of russia are diagnosed in the volga federal district, which includes the republic of tatarstan (rt). the current study aims to analyze the genetic variability of puuv in pre-kama region of the rt bounded by the volga, kama, and vyatka rivers. in 2017, bank voles were caught in seven isolated f ... | 2020 | 32640614 |
| the metabolic performance predicts home range size of bank voles: a support for the behavioral-bioenergetics theory. | the pace-of-life syndrome describes covariation between life-history, behavioral and physiological traits; while, the emerging behavioral-bioenergetics theory proposes mechanistic links between those traits in a spatial-ecological context. however, little is known about the association between the limits to metabolic rate and spatial performance (i.e., mobility, home range size) in free-living individuals. here we show, for the first time at the intra-specific level, that mobility traits increas ... | 2020 | 32638120 |
| does selection for behavioral and physiological performance traits alter glucocorticoid responsiveness in bank voles? | one of the key elements of an animal's darwinian fitness is its ability to adequately respond to and cope with challenging situations. glucocorticoid hormones, such as corticosterone, affect an organism's ability to overcome such challenges. we hypothesized that changes in the glucocorticoid response curve contribute to the evolution of increased performance during challenging conditions, and tested it on bank voles (myodes glareolus) from a multidirectional artificial selection experiment, whic ... | 2020 | 32561625 |
| balancing selection in pattern recognition receptor signalling pathways is associated with gene function and pleiotropy in a wild rodent. | pathogen-mediated balancing selection is commonly considered to play an important role in the maintenance of genetic diversity, in particular in immune genes. however, the factors that may influence which immune genes are the targets of such selection are largely unknown. to address this, here we focus on pattern recognition receptor (prr) signalling pathways, which play a key role in innate immunity. we used whole-genome resequencing data from a population of bank voles (myodes glareolus) to te ... | 2020 | 32374503 |
| isolation and characterization of new puumala orthohantavirus strains from germany. | orthohantaviruses are re-emerging rodent-borne pathogens distributed all over the world. here, we report the isolation of a puumala orthohantavirus (puuv) strain from bank voles caught in a highly endemic region around the city osnabrück, north-west germany. coding and non-coding sequences of all three segments (s, m, and l) were determined from original lung tissue, after isolation and after additional passaging in veroe6 cells and a bank vole-derived kidney cell line. different single amino ac ... | 2020 | 32328924 |
| orthohantavirus isolated in reservoir host cells displays minimal genetic changes and retains wild-type infection properties. | : orthohantaviruses are globally emerging zoonotic pathogens. while the reservoir host role of several rodent species is well-established, detailed research on the mechanisms of host-othohantavirus interactions has been constrained by the lack of an experimental system that is able to effectively replicate natural infections in controlled settings. here we report the isolation, and genetic and phenotypic characterization of a novel puumala orthohantavirus (puuv) in cells derived from its reservo ... | 2020 | 32316667 |
| isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease. | prions are transmissible agents causing lethal neurodegenerative diseases that are composed of aggregates of misfolded cellular prion protein (prpsc). despite non-fibrillar oligomers having been proposed as the most infectious prion particles, prions purified from diseased brains usually consist of large and fibrillar prpsc aggregates, whose protease-resistant core (prpres) encompasses the whole c-terminus of prp. in contrast, prpsc from gerstmann-sträussler-scheinker disease associated with ala ... | 2020 | 32303068 |
| cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation. | prion diseases are caused by the misfolding of a host-encoded glycoprotein, prpc, into a pathogenic conformer, prpsc. infectious prions can exist as different strains, composed of unique conformations of prpsc that generate strain-specific biological traits, including distinctive patterns of prpsc accumulation throughout the brain. prion strains from different animal species display different cofactor and prpc glycoform preferences to propagate efficiently in vitro, but it is unknown whether the ... | 2020 | 32294141 |
| high genomic diversity in the bank vole at the northern apex of a range expansion: the role of multiple colonizations and end-glacial refugia. | the history of repeated northern glacial cycling and southern climatic stability has long dominated explanations for how genetic diversity is distributed within temperate species in eurasia and north america. however, growing evidence indicates the importance of cryptic refugia for northern colonization dynamics. an important geographic region to assess this is fennoscandia, where recolonization at the end of the last glaciation was restricted to specific routes and temporal windows. we used gen ... | 2020 | 32248595 |
| combining genome-wide association study and fst -based approaches to identify targets of borrelia-mediated selection in natural rodent hosts. | recent advances in high-throughput sequencing technologies provide opportunities to gain novel insights into the genetic basis of phenotypic trait variation. yet to date, progress in our understanding of genotype-phenotype associations in nonmodel organisms in general and natural vertebrate populations in particular has been hampered by small sample sizes typically available for wildlife populations and a resulting lack of statistical power, as well as a limited ability to control for false-posi ... | 2020 | 32163646 |
| ticks on the channel islands and implications for public health. | the channel islands are british crown dependencies located in the english channel to the west of the normandy coast in northern france. whilst there have been studies investigating tick occurrence and distribution in different habitats on the mainland of the uk and in france, the channel islands have been relatively understudied. as such, little is known about whether the sheep tick, ixodes ricinus, is present, and whether there is a potential risk of lyme borreliosis on the channel islands. to ... | 2020 | 32046929 |
| spatio-temporal variation of metals and organic contaminants in bank voles (myodes glareolus). | environmental contamination with metals and organic compounds is of increasing concern for ecosystem and human health. still, our knowledge about spatial distribution, temporal changes and ecotoxicological fate of metals and organic contaminants in wildlife is limited. we studied concentrations of 69 elements and 50 organic compounds in 300 bank voles (myodes glareolus), europe's most common mammal, sampled in spring and autumn 2017-2018 in five monitoring areas, representing three biogeographic ... | 2020 | 31955071 |
| deciphering copper coordination in the mammalian prion protein amyloidogenic domain. | prions are pathological isoforms of the cellular prion protein that is responsible for transmissible spongiform encephalopathies (tse). cellular prion protein interacts with copper, cu(ii), through octarepeat and nonoctarepeat (non-or) binding sites. the molecular details of cu(ii) coordination within the non-or region are not well characterized yet. by the means of small angle x-ray scattering and x-ray absorption spectroscopic methods, we have investigated the effect of cu(ii) on prion protein ... | 2020 | 31952810 |
| infection load and prevalence of novel viruses identified from the bank vole do not associate with exposure to environmental radioactivity. | bank voles (myodes glareolus) are host to many zoonotic viruses. as bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated dna repair activity, we predicted an association between virome composition and exposure to radionuclides. to test this hypothesis, we studied the bank vole virome in samples of plasma derived from animals inhabiting areas of ukraine (contaminated areas surrounding the former nuclear power plant at che ... | 2019 | 31905955 |
| quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents. | detection of misfolded prion protein, prptse, in biological samples is important to develop antemortem tests for transmissible spongiform encephalopathies (tses). the real-time quaking-induced conversion (rt-quic) assay detects prptse but requires dedicated equipment and relatively long incubation times when applied to samples containing extremely low levels of prptse. it was shown that a microplate shaker with heated top (thermomixer-c) accelerated amplification of prptse in brain suspensions o ... | 2019 | 31830760 |
| use of different rt-quic substrates for detecting cwd prions in the brain of norwegian cervids. | chronic wasting disease (cwd) is a highly contagious prion disease affecting captive and free-ranging cervid populations. cwd has been detected in united states, canada, south korea and, most recently, in europe (norway, finland and sweden). animals with cwd release infectious prions in the environment through saliva, urine and feces sustaining disease spreading between cervids but also potentially to other non-cervids ruminants (e.g. sheep, goats and cattle). in the light of these consideration ... | 2019 | 31819115 |
| wildfire-induced short-term changes in a small mammal community increase prevalence of a zoonotic pathogen? | natural disturbances like droughts and fires are important determinants of wildlife community structure and are suggested to have important implications for prevalence of wildlife-borne pathogens. after a major wildfire affecting >1,600 ha of boreal forest in sweden in 2006, we took the rare opportunity to study the short-term response (2007-2010 and 2015) of small mammal community structure, population dynamics, and prevalence of the puumala orthohantavirus (puuv) hosted by bank voles (myodes g ... | 2019 | 31788190 |
| retraction: in vitro studies of interactions between frequent and unique mrnas and cytoplasmic factors from brain tissue of several species of wild timber voles of northern eurasia, clethrionomys glareolus, clethrionomys frater and clethrionomys gapperi: a new criticism to a modern molecular-genetic concept of biological evolution. | | 2020 | 31701785 |
| levels, patterns, and biomagnification potential of perfluoroalkyl substances in a terrestrial food chain in a nordic skiing area. | perfluoroalkyl substances (pfass) are used in a wide range of consumer products, including ski products, such as ski waxes. however, there is limited knowledge on the release of pfass from such products into the environment and the resultant uptake in biota and transport in food webs. we investigated levels, patterns, and biomagnification of pfass in soil, earthworms (eisenia fetida), and bank voles (myodes glareolus) from a skiing area in trondheim, norway. in general, there was higher pfas lev ... | 2019 | 31691564 |
| heterogeneous puumala orthohantavirus situation in endemic regions in germany in summer 2019. | puumala orthohantavirus (puuv) causes most human hantavirus disease cases in europe. puuv disease outbreaks are usually synchronized germany-wide driven by beech mast-induced irruptions of its host (bank vole, myodes glareolus). recent data indicate high vole abundance, high puuv prevalence and high human incidence in summer 2019 for some regions, but elsewhere values were low to moderate. this significant lack of synchrony among regions in germany is in contrast to previous studies. health inst ... | 2020 | 31674714 |
| one-decade-spanning transgenerational effects of historic radiation dose in wild populations of bank voles exposed to radioactive contamination following the chernobyl nuclear disaster. | the concept of historic radiation doses associated with accidental radioactive releases and their role in leading to radiation-induced non-targeted effects on affected wild animals are currently being evaluated. previous research studying fukushima butterfly, chernobyl bird and fruit fly populations shows that the effects are transgenerational, underlined by the principles of genomic instability, and varied from one species to another. to further expand on the responses of and their sensitivity ... | 2020 | 31627157 |
| stress coping and evolution of aerobic exercise performance: corticosterone levels in voles from a selection experiment. | the locomotor performance achieved in a challenging situation depends not only on physiological limitations, such as the aerobic exercise capacity, but also on behavioral characteristics, such as adequate coping with stress. the stress response is mediated largely by the hypothalamic-pituitary-adrenal (hpa) axis, through modulated release of glucocorticoids. we used a unique experimental evolution model system to test the hypothesis that the evolution of an increased aerobic exercise performance ... | 2019 | 31548286 |
| maternal antibodies provide bank voles with strain-specific protection against infection by the lyme disease pathogen. | multistrain microbial pathogens often induce strain-specific antibody responses in their vertebrate hosts. mothers can transmit antibodies to their offspring, which can provide short-term, strain-specific protection against infection. few experimental studies have investigated this phenomenon for multiple strains of zoonotic pathogens occurring in wildlife reservoir hosts. the tick-borne bacterium borrelia afzelii causes lyme disease in europe and consists of multiple strains that cycle between ... | 2019 | 31540991 |
| exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent. | wildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in dna damage and/or oxidative stress commonly associated with radiation exposure. to examine the effects of exposure to radiation on gene expression in wildlife, we conducted a de novo rna sequencing study of liver and spleen tissues from a rodent, the bank vole myodes glareolus. bank voles were collected from the chernobyl exclu ... | 2019 | 31498518 |
| rodent mothers increase vigilance behaviour when facing infanticide risk. | infanticide, the killing of unrelated young, is widespread and frequently driven by sexual conflict. especially in mammals with exclusive maternal care, infanticide by males is common and females suffer fitness costs. recognizing infanticide risk and adjusting offspring protection accordingly should therefore be adaptive in female mammals. using a small mammal (myodes glareolus) in outdoor enclosures, we investigated whether lactating mothers adjust offspring protection, and potential mate searc ... | 2019 | 31427633 |
| effect of estrogen-related receptor silencing on mirna protein machinery expression, global methylation, and deacetylation in bank vole (myodes glareolus) and mouse tumor leydig cells. | the function of estrogen-related receptor (err) in testicular cells is at the beginning of exploration. our previous findings showed that expression pattern of estrogen-related receptor (err) in mouse leydig cell depends on physiological status of the cell. exogenous hormones/hormonally active chemicals affect err expression. in leydig cells in vitro, errα and errγ show opposing regulatory properties. the aim of this study was to examine the role of err in epigenetic processes in cells with alte ... | 2019 | 31421412 |
| the effect of monoamines reuptake inhibitors on aerobic exercise performance in bank voles from a selection experiment. | exercise performance depends on both physiological abilities (e.g., muscle strength) and behavioral characteristics (e.g., motivation). we tested the hypothesis that evolution of increased aerobic exercise performance can be facilitated by evolution of neuropsychological mechanisms responsible for motivation to undertake physical activity. we used a unique model system: lines of bank voles myodes glareolus selected for high swim-induced aerobic metabolism ("aerobic" a lines). in generation 21, v ... | 2019 | 31413714 |
| experimental evolution of personality traits: open-field exploration in bank voles from a multidirectional selection experiment. | evolution of complex physiological adaptations could be driven by natural selection acting on behavioral traits. consequently, animal personality traits and their correlation with physiological traits have become an engaging research area. here, we applied a unique experimental evolution model-lines of bank voles selected for (a) high exercise-induced aerobic metabolism, (h) ability to cope with low-quality herbivorous diet, and (p) intensity of predatory behavior, that is, traits shaping evolut ... | 2019 | 31413710 |
| early life of fathers affects offspring fitness in a wild rodent. | intergenerational fitness effects on offspring due to the early life of the parent are well studied from the standpoint of the maternal environment, but intergenerational effects owing to the paternal early life environment are often overlooked. nonetheless, recent laboratory studies in mammals and ecologically relevant studies in invertebrates predict that paternal effects can have a major impact on the offspring's phenotype. these nongenetic, environment-dependent paternal effects provide a me ... | 2019 | 31390473 |
| phylogeography of puumala orthohantavirus in europe. | puumala virus is an rna virus hosted by the bank vole (myodes glareolus) and is today present in most european countries. whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, puumala virus (puuv) evolutionary history is still controversial and so far has not been studied at the whole european level. this study attempts to reconstruct the phylogeographical spread of modern puuv throughout europe during the last postglacial period in the light of an upg ... | 2019 | 31344894 |
| zoonotic virus seroprevalence among bank voles, poland, 2002-2010. | bank voles in poland are reservoirs of zoonotic viruses. to determine seroprevalence of hantavirus, arenavirus, and cowpox virus and factors affecting seroprevalence, we screened for antibodies against these viruses over 9 years. cowpox virus was most prevalent and affected by extrinsic and intrinsic factors. long-term and multisite surveillance is crucial. | 2019 | 31310209 |
| individual variation in cognitive style reflects foraging and anti-predator strategies in a small mammal. | balancing foraging gain and predation risk is a fundamental trade-off in the life of animals. individual strategies to acquire, process, store and use information to solve cognitive tasks are likely to affect speed and flexibility of learning, and ecologically relevant decisions regarding foraging and predation risk. theory suggests a functional link between individual variation in cognitive style and behaviour (animal personality) via speed-accuracy and risk-reward trade-offs. we tested whether ... | 2019 | 31300696 |
| cytokine storm combined with humoral immune response defect in fatal hemorrhagic fever with renal syndrome case, tatarstan, russia. | hemorrhagic fever with renal syndrome (hfrs) is endemic in tatarstan, where thousands of cases are registered annually. puumalaorthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. the pathogenesis of hfrs is still not well described, although the cytokine storm hypothesis is largely accepted. in this study, we present a comprehensive analysis of a fatal hfrs case compared with twenty four non-fatal cases where activation of the humoral a ... | 2019 | 31269734 |
| consistent within-group covariance of septal and temporal hippocampal neurogenesis with behavioral phenotypes for exploration and memory retention across wild and laboratory small rodents. | striking differences in the septo-temporal distribution of neurogenesis are found in small rodents. here, we assessed the association of adult hippocampal neurogenesis with behavioral responses to novelty, temporal and spatial sequence and reversal learning in wild, wild-derived and laboratory rodents using an automated testing apparatus, the intellicage. behaviorally, dba/2 and wild-derived house mice were quickest to explore a novel environment, wild wood mice and bank voles were slowest, and ... | 2019 | 31201873 |
| seroprevalence of trichinella spp. infection in bank voles (myodes glareolus) - a long term study. | rodents play an important role as reservoir hosts of zoonotic diseases. as a component of our long-term programme of monitoring parasitic infections in bank vole populations in three ecologically similar sites in ne poland, we screened blood samples for signs of a serological response to the presence of trichinella spp. the overall seroprevalence of trichinella spp. was 1.52%, but prevalence was largely concentrated in one of our three study sites and confined to the oldest individuals in the st ... | 2019 | 31193257 |
| is experimental evolution of an increased aerobic exercise performance in bank voles mediated by endocannabinoid signaling pathway? | the level of physical activity achieved in a given situation depends on both physiological abilities and behavioral characteristics (motivation). we used a unique animal model to test a hypothesis that evolution of an increased aerobic exercise performance can be facilitated by evolution of motivation to undertake physical activity, mediated by brain endocannabinoid system. bank voles (myodes glareolus) from "aerobic" a lines selected for 22 generations for high swim-induced aerobic metabolism ( ... | 2019 | 31191344 |
| intergenerational fitness effects of the early life environment in a wild rodent. | the early life environment can have profound, long-lasting effects on an individual's fitness. for example, early life quality might (a) positively associate with fitness (a silver spoon effect), (b) stimulate a predictive adaptive response (by adjusting the phenotype to the quality of the environment to maximize fitness) or (c) be obscured by subsequent plasticity. potentially, the effects of the early life environment can persist beyond one generation, though the intergenerational plasticity o ... | 2019 | 31162628 |
| the role of juvenile dermacentor reticulatus ticks as vectors of microorganisms and the problem of 'meal contamination'. | juvenile dermacentor reticulatus ticks inhabit nests and burrows of their rodent hosts and cannot be collected from vegetation. to detect vertical transmission of babesia canis in d. reticulatus, we studied larvae and nymphs collected from rodents. however, the molecular techniques used for detection of pathogen dna are sensitive enough to detect not only pathogens vectored by ticks but also those taken up with current or previous blood meals ('meal contamination') or just present in the environ ... | 2019 | 31119415 |
| do phase-dependent life history traits in cyclic voles persist in a common environment? | phenotype and life history traits of an individual are a product of environmental conditions and the genome. environment can be current or past, which complicates the distinction between environmental and heritable effects on the phenotype in wild animals. we studied genome-environment interactions on phenotype and life history traits by transplanting bank voles (myodes glareolus) from northern and southern populations, originating from low or high population cycle phases, to common garden condi ... | 2019 | 31065806 |
| how general are generalist parasites? the small mammal part of the lyme disease transmission cycle in two ecosystems in northern europe. | the pathogens causing lyme disease are all vectored by generalist tick species found on a wide range of vertebrates, but spatial and annual variation in host use has rarely been quantified. we here compare the load of ixodes ricinus (the vector) on small mammals and investigate the infection prevalence of borrelia burgdorferi s.l. (the pathogen) involved in the enzootic transmission cycle of lyme disease in two contrasting ecosystems in norway from 2014 to 2016. the most common larval tick host ... | 2019 | 31062166 |
| susceptibility to infection with borrelia afzelii and tlr2 polymorphism in a wild reservoir host. | the study of polymorphic immune genes in host populations is critical for understanding genetic variation in susceptibility to pathogens. controlled infection experiments are necessary to separate variation in the probability of exposure from genetic variation in susceptibility to infection, but such experiments are rare for wild vertebrate reservoir hosts and their zoonotic pathogens. the bank vole (myodes glareolus) is an important reservoir host of borrelia afzelii, a tick-borne spirochete th ... | 2019 | 31040326 |
| identifying the patterns and drivers of puumala hantavirus enzootic dynamics using reservoir sampling. | hantaviruses are zoonotic hemorrhagic fever viruses for which prevention of human spillover remains the first priority in disease management. tailored intervention measures require an understanding of the drivers of enzootic dynamics, commonly inferred from distorted human incidence data. here, we use longitudinal sampling of approximately three decades of puumala orthohantavirus (puuv) evolution in isolated reservoir populations to estimate puuv evolutionary rates, and apply these to study the ... | 2019 | 31024739 |
| experimental evolution of aerobic exercise performance and hematological traits in bank voles. | the maximum rate of aerobic exercise metabolism (vo2max) is a trait informative from both medical and evolutionary perspective, and both the physiological mechanisms limiting its level and its evolution are subject to vivid debate. both comparative analyses and studies on the effects of training or acclimation to aerobically-demanding conditions suggest a role of oxygen transport-related properties of blood in limiting vo2max. here we used a unique experimental evolution model - lines of bank vo ... | 2019 | 31004810 |
| the polar clasps of a bank vole prp(168-176) prion protofibril revisiting. | on 2018-01-17 two electron crystallography structures (with pdb entries 6axz, 6btk) on a prion protofibril of bank vole prp(168-176) (a segment in the prp β2-α2 loop) were released into the pdb bank. the paper published by gallagher-jones et al. (nat struct mol biol 25(2):131-134, 2018) reports some polar clasps for these two crystal structures, and "an intersheet hydrogen bond between tyr169 and the backbone carbonyl of asn171 on an opposing strand."-this hydrogen bond is not directly between t ... | 2019 | 30937536 |
| full restoration of specific infectivity and strain properties from pure mammalian prion protein. | the protein-only hypothesis predicts that infectious mammalian prions are composed solely of prpsc, a misfolded conformer of the normal prion protein, prpc. however, protein-only prpsc preparations lack significant levels of prion infectivity, leading to the alternative hypothesis that cofactor molecules are required to form infectious prions. here, we show that prions with parental strain properties and full specific infectivity can be restored from protein-only prpsc in vitro. the restoration ... | 2019 | 30908557 |
| a single amino acid substitution, found in mammals with low susceptibility to prion diseases, delays propagation of two prion strains in highly susceptible transgenic mouse models. | specific variations in the amino acid sequence of prion protein (prp) are key determinants of susceptibility to prion diseases. we previously showed that an amino acid substitution specific to canids confers resistance to prion diseases when expressed in mice and demonstrated its dominant-negative protective effect against a variety of infectious prion strains of different origins and characteristics. here, we show that expression of this single amino acid change significantly increases survival ... | 2019 | 30847740 |
| detection of antibodies to borrelia burgdorferi s.l. in wild small mammals and sensitivity of pcr and cultivation. | the aim of this study was to determine the seroprevalence of antibodies to b. burgdorferi s.l. in wild small mammals in the czech republic and compare sensitivity of pcr and cultivaton. wild small mammals (n = 691) were trapped in years 2010-2014 in three localities of the czech republic. heart rinses (n = 340) and sera (n = 351) were examined by modified indirect elisa. seventy animals were randomly selected for comparison of results of cultivation and pcr. mean annual antiborelian positivity w ... | 2019 | 30827395 |
| individuals in space: personality-dependent space use, movement and microhabitat use facilitate individual spatial niche specialization. | personality-dependent space use and movement might be crucially influencing ecological interactions, giving way to individual niche specialization. this new approach challenges classical niche theory with potentially great ecological consequences, but so far has only scarce empirical support. here, we investigated if and how consistent inter-individual differences in behavior predict space use and movement patterns in free-ranging bank voles (myodes glareolus) and thereby contribute to individua ... | 2019 | 30826867 |
| molecular identification of puumala orthohantavirus in bulgaria. | in bulgaria, only dobrava orthohantavirus has been detected in patients and in rodents. in order to elucidate possible puumala orthohantavirus (puuv) circulation, 131 bank voles (myodes glareolus) were captured. puuv rna was detected in 14 (10.7%). partial l segment sequences were recovered from six m. glareolus. phylogenetic analysis showed that all puuv sequences from this study clustered together among the alpe-adrian lineage. it is the first genetic evidence of the virus circulation in a bal ... | 2019 | 30798033 |
| major histocompatibility complex class i diversity limits the repertoire of t cell receptors. | major histocompatibility complex (mhc) genes encode proteins that initiate adaptive immune responses through the presentation of foreign antigens to t cells. the high polymorphism found at these genes, thought to be promoted and maintained by pathogen-mediated selection, contrasts with the limited number of mhc loci found in most vertebrates. although expressing many diverse mhc genes should broaden the range of detectable pathogens, it has been hypothesized to also cause deletion of larger frac ... | 2019 | 30796191 |
| isosporan oocysts in the faeces of bank voles (myodes glareolus; arvicolinae, rodentia): real parasites, or pseudoparasites? | coccidia of the genus isospora, their origin, taxonomy, and host specificity have been discussed for many years. the crucial point in question being the division of the genus, based on distinct evolutionary history and the presence/absence of the stieda body, into the genera isospora (eimeriidae) parasitizing mainly birds and reptiles, and cystoisospora (sarcocystidae) parasitizing mammals. the description of the majority of isospora species from rodents is based solely on the oocysts found in t ... | 2019 | 30738338 |
| exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length. | telomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. in some species, the enzyme telomerase is expressed in adult somatic tissues, and potentially protects or lengthens telomeres. telomeres can be damaged by ionizing radiation and oxidative stress, although the effect of chronic exposure to elevated levels of radiation on telomere maintenance is unknown for natural populations. we quantified telomerase expression and telomere l ... | 2019 | 30696885 |
| [first case of nephropathia epidemica in southern sweden]. | nephropathia epidemica (ne) is the european version of hemorrhagic fever with renal syndrome. ne is caused by the puumala type of hantavirus with the bank vole (clethrionomys glareolus) as the natural reservoir. endemic regions include northern sweden with an incidence of 53 to 569 cases per year, depending on the cyclic variation of rodent populations. in southern sweden, south of the mälardalen region, no cases of ne have been described without a historical account of travel to endemic areas i ... | 2019 | 30694519 |
| phase- and season-dependent changes in social behaviour in cyclic vole populations. | social behaviour has been linked to hypotheses explaining multiannual population cycles of small rodents. in this paper we aimed to test empirically that the degree of space sharing among adult breeding female voles is higher during the increase phase than in the crash phase, and that the degree of sociality is positively related to population growth rate as suggested by lambin and krebs (oikos 61:126-132, 1991) and andreassen et al. (oikos 122:507-515, 2013). we followed 24 natural bank vole my ... | 2019 | 30683090 |
| diet shift in bank voles induced by competition from grey-sided voles? | grey-sided voles (myodes rufocanus) and bank voles (myodes glareolus) co-exist in boreal forests in northern scandinavia. previous studies suggest that the 2 species interact interspecifically, the grey-sided vole being the dominant species. we tested the hypothesis that bank voles shift their diet due to competition with the dominant grey-sided vole by studying stable isotope ratios in both species. muscle samples were taken from voles in patches of old forest occupied by only bank voles and pa ... | 2019 | 30585416 |
| olfactory cues and the value of information: voles interpret cues based on recent predator encounters. | prey strategically respond to the risk of predation by varying their behavior while balancing the tradeoffs of food and safety. we present here an experiment that tests the way the same indirect cues of predation risk are interpreted by bank voles, myodes glareolus, as the game changes through exposure to a caged weasel. using optimal patch use, we asked wild-caught voles to rank the risk they perceived. we measured their response to olfactory cues in the form of weasel bedding, a sham control i ... | 2018 | 30573941 |
| variable protease-sensitive prionopathy transmission to bank voles. | variably protease-sensitive prionopathy (vpspr), a recently described human sporadic prion disease, features a protease-resistant, disease-related prion protein (resprpd) displaying 5 fragments reminiscent of gerstmann-sträussler-scheinker disease. experimental vpspr transmission to human prp-expressing transgenic mice, although replication of the vpspr resprpd profile succeeded, has been incomplete because of second passage failure. we bioassayed vpspr in bank voles, which are susceptible to hu ... | 2019 | 30561322 |
| skin and gut microbiomes of a wild mammal respond to different environmental cues. | animal skin and gut microbiomes are important components of host fitness. however, the processes that shape the microbiomes of wildlife are poorly understood, particularly with regard to exposure to environmental contaminants. we used 16s rrna amplicon sequencing to quantify how exposure to radionuclides impacts the skin and gut microbiota of a small mammal, the bank vole myodes glareolus, inhabiting areas within and outside the chernobyl exclusion zone (cez), ukraine. | 2018 | 30477569 |
| exposure to chemical cues from predator-exposed conspecifics increases reproduction in a wild rodent. | predation involves more than just predators consuming prey. indirect effects, such as fear responses caused by predator presence, can have consequences for prey life history. laboratory experiments have shown that some rodents can recognize fear in conspecifics via alarm pheromones. individuals exposed to alarm pheromones can exhibit behavioural alterations that are similar to those displayed by predator-exposed individuals. yet the ecological and evolutionary significance of alarm pheromones in ... | 2018 | 30464245 |
| the scent of infanticide risk? behavioural allocation to current and future reproduction in response to mating opportunity and familiarity with intruder. | the killing of young by unrelated males is widespread in the animal kingdom. in short-lived small rodents, females can mate immediately after delivery (post-partum oestrus) and invest in future reproduction, but infanticide may put the nestlings, their current reproductive investment, at risk. here, we investigated the behavioural trade-offs between mating interest and nest protection in an arena experiment with bank voles (myodes glareolus). non-gravid females (n = 33) were housed at one end of ... | 2018 | 30459482 |
| telocytes are localized to testis of the bank vole (myodes glareolus) and are affected by lighting conditions and g-coupled membrane estrogen receptor (gper) signaling. | we aim to explore the presence of a novel cell type, telocytes (tcs), in the bank vole testis interstitium following g-coupled membrane estrogen receptor (gper) signaling withdrawal. in addition, the involvement of interstitial cells in lipid homeostasis was investigated. bank voles (actively reproducing or regressed) were administered with gper antagonist (g-15; 50 μg/kg bw) injections. to examine tc distribution, ultrastructure, function, and their connotation in the interstitial tissue lipid ... | 2019 | 30391242 |
| playing hide-and-seek in beta-globin genes: gene conversion transferring a beneficial mutation between differentially expressed gene duplicates. | increasing evidence suggests that adaptation to diverse environments often involves selection on existing variation rather than new mutations. a previous study identified a nonsynonymous single nucleotide polymorphism (snp) in exon 2 of two paralogous β-globin genes of the bank vole (clethrionomys glareolus) in britain in which the ancestral serine (ser) and the derived cysteine (cys) allele represent geographically partitioned functional variation affecting the erythrocyte antioxidative capacit ... | 2018 | 30321987 |
| fibroblasts from bank voles inhabiting chernobyl have increased resistance against oxidative and dna stresses. | elevated levels of environmental ionizing radiation can be a selective pressure for wildlife by producing reactive oxygen species and dna damage. however, the underlying molecular mechanisms that are affected are not known. | 2018 | 30157751 |
| oxidative damage and antioxidant defense are assay and tissue-dependent both in captive and wild-caught bank voles (myodes glareolus) before and after reproduction. | reproduction is costly and life-history theory predicts that current parental investment will result in lower survival or decreased future reproduction. the physiological mechanisms mediating the link between reproduction and survival are still under debate and elevated oxidative damage during reproduction has been proposed as a plausible candidate. previous studies of oxidative stress during reproduction in animals under natural conditions have been restricted to analyses of blood. herein, we m ... | 2018 | 30151169 |
| seroprevalence of tbev in bank voles from poland-a long-term approach. | rodents are known to play a significant role as reservoir hosts for tbev. during three sequential expeditions at 4-year intervals to three ecologically similar study sites in ne poland, we trapped bank voles (myodes glareolus) and then tested their blood for the presence of specific antiviral antibodies to tbev. the strongest effects on seroprevalence were the extrinsic factors, site of capture of voles and year of sampling. seroprevalence increased markedly with increasing host age, and our ana ... | 2018 | 30108201 |
| profiling of the tcrβ repertoire in non-model species using high-throughput sequencing. | in recent years, immune repertoire profiling with high-throughput sequencing (hts) has advanced our understanding of adaptive immunity. however, fast progress in the field applied mostly to human and mouse research, with only few studies devoted to other model vertebrates. we present the first in-depth characterization of the t-cell receptor (tcr) repertoire in a non-model mammal (bank vole, myodes glareolus), widely used in ecological and evolutionary research. we used rna from spleens, 5'race ... | 2018 | 30072736 |
| a domain responsible for spontaneous conversion of bank vole prion protein. | bank vole is a small rodent that shows high susceptibility to infection with diverse prion strains. to determine whether the increased susceptibility of bank voles to prion diseases can be attributed to the intrinsic nature of bank vole prion protein (prp) or to host factors other than prp, we produced transgenic mice overexpressing bank vole prp. these transgenic mice spontaneously developed neurological illness with spongiform changes and the accumulation of abnormal prp in the brain. then, we ... | 2019 | 30051525 |
| small-scale spatial variation in infection risk shapes the evolution of a borrelia resistance gene in wild rodents. | spatial variation in pathogen-mediated selection is predicted to influence the evolutionary trajectory of host populations and lead to spatial variation in their immunogenetic composition. however, to date few studies have been able to directly link small-scale spatial variation in infection risk to host immune gene evolution in natural, nonhuman populations. here, we use a natural rodent-borrelia system to test for associations between landscape-level spatial variation in borrelia infection ris ... | 2018 | 30040159 |
| high throughput sequencing and network analysis disentangle the microbial communities of ticks and hosts within and between ecosystems. | we aimed to develop a framework, based on graph theory, to capture the ecological meaning behind pure pair comparisons of microbiome-derived data. as a proof of concept, we applied the framework to analyze the co-occurrence of bacteria in either ixodes ricinus ticks or the spleen of one of their main hosts, the vole myodes glareolus. as a secondary lymphoid organ, the spleen acts as a filter of blood and represents well the exposure to microorganisms circulating in the blood; including those acq ... | 2018 | 30038903 |
| peculiarities of hematopoiesis in small rodents from the chornobyl exclusion zone on the background of extreme environment. | radiobiological investigations of natural populations of myodes glareolus (bank vole) from the chornobyl exclusion zone, namely within a highly radioactive site of the red forest were carried out. the complex of hematological and cytogenetic parameters of the bank voles inhabiting the contaminated site was studied before the site was flooded, in 2012, and after it drained, in 2015. a significant increase in micronucleated polychromatic erythrocytes, alterations in bone marrow and peripheral bloo ... | 2020 | 30033147 |
| socio-reproductive conflicts and the father's curse dilemma. | evolutionary conflicts between males and females can manifest over sexually antagonistic interactions at loci or over sexually antagonistic interests within a locus. the latter form of conflict, intralocus sexual conflict, arises from sexually antagonistic selection and constrains the fitness of individuals through a phenotypic compromise. these conflicts, and socio-reproductive interactions in general, are commonly mediated by hormones, and thus predictive insights can be gained from studying t ... | 2018 | 30016171 |
| parasites in myodes glareolus and their association with diet assessed by stable isotope analysis. | vertebrates are hosts to numerous parasites, belonging to many different taxa. these parasites differ in transmission, being through either direct contact, a faecal-oral route, ingestion of particular food items, vertical or sexual transmission, or by a vector. assessing the impact of diet on parasitism can be difficult because analysis of faecal and stomach content are uncertain and labourious; and as with molecular methods, do not provide diet information over a longer period of time. we here ... | 2018 | 29988840 |
| environmental radiation alters the gut microbiome of the bank vole myodes glareolus. | gut microbiota composition depends on many factors, although the impact of environmental pollution is largely unknown. we used amplicon sequencing of bacterial 16s rrna genes to quantify whether anthropogenic radionuclides at chernobyl (ukraine) impact the gut microbiome of the bank vole myodes glareolus. exposure to elevated levels of environmental radionuclides had no detectable effect on the gut community richness but was associated with an almost two-fold increase in the firmicutes:bacteroid ... | 2018 | 29988064 |
| analysis of heteroplasmy in bank voles inhabiting the chernobyl exclusion zone: a commentary on baker et al. (2017) "elevated mitochondrial genome variation after 50 generations of radiation exposure in a wild rodent." | | 2018 | 29875822 |
| signatures of balancing selection in toll-like receptor (tlrs) genes - novel insights from a free-living rodent. | selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by multiple components of the immune system, gaining a better understanding of the mechanisms of parasite-driven selection requires the study of multiple genes and pathogens. toll-like receptors (tlrs) are a large gene family that code for antigen-presen ... | 2018 | 29849060 |
| tissue trace elements and lipid peroxidation in breeding female bank voles myodes glareolus. | recent studies have demonstrated that reproduction reduces oxidative damage in various tissues of small mammal females. the present work was designed to determine whether the reduction of oxidative stress in reproductive bank vole females was associated with changes in tissue trace elements (iron, copper, zinc) that play an essential role in the production of reactive oxygen species. lipid peroxidation (a marker of oxidative stress) and iron concentration in liver, kidneys, and skeletal muscles ... | 2019 | 29704204 |
| long-term dim light during nighttime changes activity patterns and space use in experimental small mammal populations. | artificial light at night (alan) is spreading worldwide and thereby is increasingly interfering with natural dark-light cycles. meanwhile, effects of very low intensities of light pollution on animals have rarely been investigated. we explored the effects of low intensity alan over seven months in eight experimental bank vole (myodes glareolus) populations in large grassland enclosures over winter and early breeding season, using led garden lamps. initial populations consisted of eight individua ... | 2018 | 29627754 |
| dna damage in a liver tissue of metal exposed clethrionomys glareolus. | it is widely known that some toxic agents may act on dna strand resulting in its damages. one of the possible impairments is formation of abasic sites in dna. the aim of this study was to indicate a presence of these dna sites in the liver tissue of bank voles inhabiting the vicinity of zinc/lead smelters. samples that were used originated from animals collected from unpolluted (niepołomice, teleśnica oszwarowa, mikołajki) and polluted (miasteczko śląskie, katowice, olkusz) populations. they sig ... | 2018 | 29459353 |