| viral etiology of bronchiolitis among pediatric inpatients in northern taiwan with emphasis on newly identified respiratory viruses. | viral etiology of bronchiolitis in children in taiwan has been fragmentary. we conducted a prospective study to figure out the viral epidemiology of bronchiolitis in taiwan. | 2014 | 23040235 |
| clinical features of different genotypes/genogroups of human metapneumovirus in hospitalized children. | to explore the clinical features of different human metapneumovirus (hmpv) genotypes/genogroups in hospitalized children. | 2013 | 23022463 |
| evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays. | the impact of viral co-infections and recently discovered viruses on the epidemiology of respiratory infections in children is still unclear. to simultaneously detect viruses that are involved in the aetiology of respiratory infections, we used a dna/rna microarray assay that identifies 17 different viruses or viral subtypes. rhinopharyngeal washes were taken from 611 children (aged 1 month to 14 years) who presented in the emergency department with respiratory infections from june 2010 to june ... | 2013 | 23020634 |
| human metapneumovirus m2-2 protein inhibits innate cellular signaling by targeting mavs. | human metapneumovirus (hmpv) is a leading cause of respiratory infections in pediatric populations globally, with no prophylactic or therapeutic measures. recently, a recombinant hmpv lacking the m2-2 protein (rhmpv-δm2-2) demonstrated reduced replication in the respiratory tract of animal models, making it a promising live vaccine candidate. however, the exact nature of the interaction between the m2-2 protein and host cells that regulates viral infection/propagation is largely unknown. by taki ... | 2012 | 23015697 |
| [molecular epidemiological and clinical feature of human metapneumovirus in children with acute lower respiratory tract infection in changsha area from 2007 to 2011]. | to understand the epidemiological characteristics of human metapneumovirus (hmpv) infection in children with acute lower respiratory tract infection (alrti) in changsha area, china. | 2012 | 23002544 |
| respiratory viruses in neonates hospitalized with acute lower respiratory tract infections. | the burden of respiratory syncytial virus (rsv) in neonates has not been clearly studied. the aims of this study were to determine the overall distribution of respiratory viruses in neonates hospitalized with acute lower respiratory tract infectiosns (alri) and to describe the clinical characteristics of rsv infections in these neonates. | 2013 | 22978535 |
| human metapneumovirus in jordan: prevalence and clinical symptoms in hospitalized pediatric patients and molecular virus characterization. | respiratory viral infections account for significant morbidity and mortality especially in young children worldwide. human metapneumovirus (hmpv) causes illnesses ranging from mild respiratory problems to bronchiolitis and severe pneumonia. from january to december 2007, 220 nasopharyngeal aspirates were collected from children younger ≤ 13 years old hospitalized with lower respiratory tract infection to detect hmpv by revese transcription-polymerase chain reaction and to clone and sequence the ... | 2012 | 22959817 |
| prevalence and characteristics of human metapneumovirus infection among hospitalized children at high risk for severe lower respiratory tract infection. | human metapneumovirus (hmpv) is a significant cause of respiratory tract infections. little is known about hmpv in children who are at high risk for lower respiratory tract infection (lrti). | 2012 | 26619409 |
| the influence of virus infections on the course of copd. | chronic obstructive pulmonary disease (copd) is extensively influenced by viral infections. the mechanisms of how viral agents affect the pathogenesis and prognosis of copd are numerous. in general, patients with infectious exacerbations are characterized by longer hospitalization periods and greater impairment of several lung function parameters than those with non-infectious exacerbations. prodromal, clinical, and outcome parameters fail to distinguish virally from non-virally induced illnesse ... | 2012 | 24688763 |
| the human metapneumovirus fusion protein mediates entry via an interaction with rgd-binding integrins. | paramyxoviruses use a specialized fusion protein to merge the viral envelope with cell membranes and initiate infection. most paramyxoviruses require the interaction of two viral proteins to enter cells; an attachment protein binds cell surface receptors, leading to the activation of a fusion (f) protein that fuses the viral envelope and host cell plasma membrane. in contrast, human metapneumovirus (hmpv) expressing only the f protein is replication competent, suggesting a primary role for hmpv ... | 2012 | 22933271 |
| acute viral lower respiratory tract infections in cambodian children: clinical and epidemiologic characteristics. | viruses are detected in most hospitalized children admitted for acute respiratory infections. etiologic understanding is needed to improve clinical management and prevention, particularly in resource-limited tropical countries. | 2013 | 22926214 |
| human metapneumovirus infection among family members. | the transmission of human metapneumovirus (hmpv) among family members is not well understood. we identified 15 families in which multiple members were diagnosed with hmpv infection by real-time pcr in 2008 and 2010. index patients ranged in age from 2 years to 11 years (median 5 years), and all 15 index cases were children who attended primary school, kindergarten, or nursery school. contact patients ranged in age from 2 months to 46 years (median 6 years). excluding five adult cases, contact pa ... | 2013 | 22874773 |
| high rates of detection of respiratory viruses in tonsillar tissues from children with chronic adenotonsillar disease. | chronic tonsillar diseases are an important health problem, leading to large numbers of surgical procedures worldwide. little is known about pathogenesis of these diseases. in order to investigate the role of respiratory viruses in chronic adenotonsillar diseases, we developed a cross-sectional study to determine the rates of viral detections of common respiratory viruses detected by taqman real time pcr (qpcr) in nasopharyngeal secretions, tonsillar tissues and peripheral blood from 121 childre ... | 2012 | 22870291 |
| diagnostic performance of two highly multiplexed respiratory virus assays in a pediatric cohort. | rapid detection of respiratory viruses is important for management and infection control in hospitalized patients. multiplex nucleic acid tests (nats) have begun to replace conventional methods as gold standards for respiratory virus detection. | 2012 | 22832060 |
| fatal human metapneumovirus and influenza b virus coinfection in an allogeneic hematopoietic stem cell transplant recipient. | human metapneumovirus (hmpv) infection can occur in all age groups with significant morbidity and mortality. coinfection with influenza virus occurs mainly with influenza type a and all reported cases recovered completely. we report the case of a 61-year-old man who had hematopoietic stem cell transplant for myelodysplastic syndrome. he was admitted to hospital for septic shock and neutropenia, and blood culture was positive for pseudomonas aeruginosa. he rapidly developed respiratory failure an ... | 2012 | 22823898 |
| molecular epidemiology of human metapneumovirus from 2009 to 2011 in okinawa, japan. | to clarify the molecular epidemiology of human metapneumovirus (hmpv) in okinawa prefecture, located in a subtropical region of japan, we performed genetic analysis of the f gene in hmpv from patients with acute respiratory infection from january 2009 to december 2011. hmpv was detected in 18 of 485 throat swabs (3.7%). phylogenetic analysis showed that 17 strains belonged to subgroup a2 and 1 strain belonged to subgroup b1. we did not observe seasonal prevalence of hmpv during the investigation ... | 2012 | 22814160 |
| chapter 11: the infant and toddler with wheezing. | recurrent wheezing is common in young infants and toddlers with 27% of all children having at least one wheezing episode by the age of 9 years. the initial wheezing episodes in young children often are linked to respiratory infections due to viral pathogens such as respiratory syncytial virus, rhinovirus, human metapneumovirus, and influenza virus. bacterial colonization of the neonatal airway also may be significant in the late development of recurrent wheeze and asthma. some 60% of children wh ... | 2016 | 22794684 |
| human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation. | the clinical characteristics of human metapneumovirus (hmpv)-associated lower respiratory tract infection (lrti) after allogeneic hematopoietic stem cell transplantation (hsct) is not well described. we describe the clinical course in eight hsct recipients suffering from hmpv infection. | 2012 | 22802096 |
| human metapneumovirus (hmpv) associated pulmonary infections in immunocompromised adults--initial ct findings, disease course and comparison to respiratory-syncytial-virus (rsv) induced pulmonary infections. | to describe computed tomography (ct)-imaging findings in human metapneumovirus (hmpv)-related pulmonary infection as well as their temporal course and to analyze resemblances/differences to pulmonary infection induced by the closely related respiratory-syncytial-virus (rsv) in immunocompromised patients. | 2012 | 22795844 |
| potential electrostatic interactions in multiple regions affect human metapneumovirus f-mediated membrane fusion. | the recently identified human metapneumovirus (hmpv) is a worldwide respiratory virus affecting all age groups and causing pneumonia and bronchiolitis in severe cases. despite its clinical significance, no specific antiviral agents have been approved for treatment of hmpv infection. unlike the case for most paramyxoviruses, the fusion proteins (f) of a number of strains, including the clinical isolate can97-83, can be triggered by low ph. we recently reported that residue h435 in the hrb linker ... | 2012 | 22761366 |
| viral infection in patients with severe pneumonia requiring intensive care unit admission. | the role of viruses in pneumonia in adults and the impact of viral infection on mortality have not been elucidated. previous studies have significant limitations in that they relied predominantly on upper respiratory specimens. | 2012 | 22700859 |
| detection and genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in southwest china. | human metapneumovirus (hmpv) is the main pathogen causing respiratory tract infection in susceptible populations, particularly in children and the elderly. specimens were collected from hospitalized children with acute lower respiratory tract infections (alrti), and the hmpv was detected by using real-time reverse transcription-pcr (rt-pcr). the full-length g gene of hmpv was amplified by rt-pcr. a total of 1,410 nasopharyngeal aspirates (npas) were collected from april 2008 to march 2011, and 1 ... | 2012 | 22692746 |
| real-time reverse transcriptase pcr assay for improved detection of human metapneumovirus. | human metapneumovirus (hmpv) is a paramyxovirus with multiple genetic lineages that is a leading cause of acute respiratory disease. several rt-pcr assays have been described based on limited available sequence data. | 2012 | 22677006 |
| sirna against the g gene of human metapneumovirus. | human metapneumovirus (hmpv) is a significant viral respiratory pathogen of infants and children, the elderly and immunocompromised individuals. disease associated with hmpv infection resembles that of human respiratory syncytial virus (rsv) and includes bronchiolitis and pneumonia. the glycosylated g attachment protein of hmpv is required for viral entry in vivo and has also been identified as an inhibitor of innate immune responses. | 2012 | 22676157 |
| respiratory failure secondary to human metapneumovirus requiring extracorporeal membrane oxygenation in a 32-month-old child. | human metapneumovirus (hmpv) is a common virus that can cause respiratory problems ranging from mild upper respiratory tract disease to respiratory failure requiring mechanical support. here, we report a case of a 32-month-old male with a previous history of asthma, who developed respiratory failure two weeks after onset of cough and rhinorrhea and required extracorporeal membrane oxygenation (ecmo) for 9 days after failing high-frequency oscillatory ventilation (hfov). to our knowledge, this is ... | 2012 | 22675646 |
| etiology and seasonality of viral respiratory infections in rural honduran children. | limited data are available in honduras that describe the etiology and seasonality of respiratory infections, especially in rural outpatient settings. better data may lead to improved therapeutic and preventive strategies. the goal of our study was to determine the viral etiology and seasonality of acute respiratory infections in a rural honduran population of children. | 2012 | 22653487 |
| [in vitro investigation of the antiviral activity of ingavirin against human metapneumovirus]. | the antiviral activity of ingavirin against human metapneumovirus (hmpv) infection was investigated in vitro. the investigation used the human cell line changconjunctiva, permissive for hmpv, clone 1-5c4, and the hmpv strain isolated at the d. i. ivanovsky research institute of virology. the experimental studies suggest that when added at a concentration of 50 to 500 microg/ml to a nutrient medium 24 hours after hmpv infection, ingavirin suppressed effectively virus replication by 2.2-3.3 logs, ... | 2016 | 22624471 |
| [prevalence of human metapneumovirus infection in hospital wards handling patients with severe motor and intellectual disabilities]. | epidemics of infectious diseases often occur in hospital wards handling patients with severe motor and intellectual disabilities. however, the causative pathogens are not identified in half of these epidemics. recently, an epidemic occurred in 2 wards consecutively in the national hospital organization ehime hospital in march-april, 2010. in this epidemic, 18 of 40 patients in one ward and 14 of 60 patients in another ward showed symptoms, and human metapneumovirus (hmpv) was detected from phary ... | 2012 | 22606877 |
| interleukin-12p40 modulates human metapneumovirus-induced pulmonary disease in an acute mouse model of infection. | the mechanisms that regulate the host immune response induced by human metapneumovirus (hmpv), a newly-recognized member of the paramyxoviridae family, are largely unknown. cytokines play an important role in modulating inflammatory responses during viral infections. il-12p40, a known important mediator in limiting lung inflammation, is induced by hmpv and its production is sustained after the resolution phase of infection suggesting that this cytokine plays a role in the immune response against ... | 2012 | 22606349 |
| paramyxovirus fusion and entry: multiple paths to a common end. | the paramyxovirus family contains many common human pathogenic viruses, including measles, mumps, the parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the zoonotic henipaviruses, hendra and nipah. while the expression of a type 1 fusion protein and a type 2 attachment protein is common to all paramyxoviruses, there is considerable variation in viral attachment, the activation and triggering of the fusion protein, and the process of viral entry. in this review, we di ... | 2012 | 22590688 |
| recent developments with live-attenuated recombinant paramyxovirus vaccines. | there is no vaccine currently approved for paramyxovirus-induced respiratory diseases in humans, despite their major clinical importance. we review the development and evaluation of new vaccine strategies based on live-attenuated chimeric and recombinant vaccines against human respiratory syncytial virus, human metapneumovirus and human parainfluenza viruses types 1 to 3, which are significant causes of upper and lower tract respiratory diseases. most promising strategies are based on virus atte ... | 2013 | 22570186 |
| epidemiology of human metapneumovirus in a pediatric long-term care facility. | viral respiratory pathogens cause outbreaks in pediatric long-term care facilities (ltcfs), but few studies have used viral diagnostic testing to identify the causative pathogens. we describe the use of such testing during a prolonged period of respiratory illness and elucidate the epidemiology of human metapneumovirus (hmpv) at our ltcf. | 2012 | 22561708 |
| comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children. | human metapneumovirus (hmpv) and respiratory syncytial virus (rsv) are leading pediatric pathogens. however, risk factors for severe hmpv disease remain unknown. we comparatively assessed environmental, host, and viral determinants for severe hmpv and rsv infections. | 2012 | 22551815 |
| spectrum of respiratory viruses in children with community-acquired pneumonia. | community-acquired pneumonia (cap) remains a significant cause for childhood morbidity worldwide. we designed a study with the objective of describing the frequency of respiratory viruses, especially rhinovirus (rv), human metapneumovirus (hmpv) and human bocavirus (hbov) in hospitalized children with cap. | 2012 | 22531244 |
| rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. | we performed a prospective study to determine the disease burden of respiratory syncytial virus (rsv) and human metapneumovirus (hmpv) in older adults in comparison with influenza virus. | 2012 | 22529314 |
| [preliminary analysis on respiratory syncytial virus identified in children with acute respiratory infections in tibet autonomous region, china]. | to understand the role of respiratory syncytial virus (rsv) in children with acute respiratory infections (ari) in tibet autonomous region and the contribution of two major groups of rsv, nasopharyngeal aspirates (npa) were collected from hospitalized children with ari in department of pediatrics, tibet people's hospital in lasa, tibet from april to july in 2011 and tested for seven common respiratory viruses and human metapneumovirus (hmpv) by direct immunofluorescence assay (dfa). total rnas w ... | 2012 | 22519168 |
| a human metapneumovirus outbreak at a community hospital in england, july to september 2010. | we describe an outbreak of human metapneumovirus (hmpv) which occurred in july-september 2010 at a community hospital in the east of england. based on the medical and nursing records, cases were retrospectively defined as suspected if they had had an influenza-like illness (ili), and probable if they had had an ili and an epidemiological link to a laboratory-confirmed case. of a total of 17 symptomatic inpatients, five were classified as probable cases, five were laboratory confirmed and seven w ... | 2012 | 22516049 |
| risk factors for hospitalization with lower respiratory tract infections in children in rural alaska. | lower respiratory tract infections (lrtis) are a major cause of morbidity for children worldwide and particularly for children from developing and indigenous populations. in this study, we evaluated risk factors for hospitalization with lrti in a region in southwest alaska. | 2012 | 22508919 |
| increase human metapneumovirus mediated morbidity following pandemic influenza infection. | human metapneumovirus (hmpv) is a recently discovered respiratory pathogen, infecting mainly young children. the infected patients suffer from influenza like symptoms (ils). in israel the virus is mainly circulating in february to march. here we report on an increased rate of hmpv infection in the winter season of 2009-10. the 2009-10 infection had several unique characteristics when compared to previous seasons; it started around january and a large number of infants were infected by the virus. ... | 2012 | 22496855 |
| an outbreak of severe respiratory tract infection caused by human metapneumovirus in a residential care facility for elderly in utrecht, the netherlands, january to march 2010. | recognition of infections with human metapneumovirus (hmpv) among institutionalised elderly is rising. when hmpv was found to be the causative agent of an outbreak of pneumonia in a residential care facility for elderly in the netherlands, an elaborate outbreak investigation was set up, including active surveillance for new cases. from clinical cases, defined by fever (> 38°c) and symptoms of respiratory tract infections, respiratory samples for analyses of viral pathogens by real-time reverse t ... | 2012 | 22490384 |
| evolutionary dynamics analysis of human metapneumovirus subtype a2: genetic evidence for its dominant epidemic. | human metapneumovirus (hmpv) is a respiratory viral pathogen in children worldwide. hmpv is divided into four subtypes: hmpv_a1, hmpv_a2, hmpv_b1, and hmpv_b2. hmpv_a2 can be further divided into hmpv_a2a and a2b based on phylogenetic analysis. the typical prevalence pattern of hmpv involves a shift of the predominant subtype within one or two years. however, hmpv_a2, in particular hmpv_a2b, has circulated worldwide with a several years long term high epidemic. to study this distinct epidemic be ... | 2012 | 22479641 |
| viral infections of the lower respiratory tract. | lower respiratory tract infections (lrtis) are a global burden to public health and are frequently caused by respiratory viruses. advances in molecular diagnostic techniques have allowed the identification of previously undetected viral pathogens and have improved our understanding of respiratory virus infections. here we review the epidemiological and clinical characteristics of recently identified viruses including human metapneumovirus, human coronaviruses nl63 and hku1, human rhinovirus c, b ... | 2012 | 22456860 |
| viral load and acute otitis media development after human metapneumovirus upper respiratory tract infection. | the role of human metapneumovirus (hmpv) in acute otitis media complicating upper respiratory tract infection (uri) was studied. nasopharyngeal specimens from 700 uri episodes in 200 children were evaluated; 47 (7%) were positive for hmpv, 25 (3.6%) with hmpv as the only virus. overall, 24% of uri episodes with hmpv only were complicated by acute otitis media, which was the lowest rate compared with other respiratory viruses. hmpv viral load was significantly higher in children with fever, but t ... | 2012 | 22411051 |
| structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. | human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. the virus fusion (f) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. f is also a major target of the neutralizing antibody response. here we show that a potently neutralizing anti-human metapneumovirus antibody (ds7) binds a structurally invariant domain of f, revealing a new epitope that could be targeted in vaccine development. | 2012 | 22388735 |
| incidence of respiratory virus-associated pneumonia in urban poor young children of dhaka, bangladesh, 2009-2011. | pneumonia is the leading cause of childhood death in bangladesh. we conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged <2 years in a low-income urban community in dhaka, bangladesh. | 2012 | 22384139 |
| new respiratory viral infections. | the first era in the discoveries of respiratory viruses occured between 1933 and 1965 when influenza virus, enteroviruses, adenovirus, respiratory syncytial virus, rhinovirus, parainfluenza virus and coronavirus (cov) were found by virus culture. in the 1990s, the development of high throughput viral detection and diagnostics instruments increased diagnostic sensitivity and enabled the search for new viruses. this article briefly reviews the clinical significance of newly discovered respiratory ... | 2012 | 22366993 |
| impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. | little is known about the prevalence of viral infections in children with community-acquired pneumonia (cap). | 2013 | 22329841 |
| evaluation of the primerdesign™ genesig real-time reverse transcription-polymerase chain reaction assay and the infiniti® respiratory viral panel plus assay for the detection of human metapneumovirus in kuwait. | human metapneumovirus (hmpv) is a respiratory pathogen that was discovered in 2001 and is considered a major cause of both upper and lower respiratory tract infections. a sensitive, fast, and high-throughput diagnostic test is needed for the detection of hmpv that may assist in the clinical management as well as in the reduction of inappropriate therapy. therefore, a comparison assessment was performed in this study between the primerdesign™ genesig real-time reverse transcription-polymerase cha ... | 2012 | 22300956 |
| human metapneumovirus (hmpv) in acute respiratory infection: a clinic-based study in egypt. | to estimate the prevalence of human metapneumovirus (hpmv), its epidemiological and clinical features in infants and children with respiratory infections, attending outpatients' clinic of mansoura university children hospital (much). | 2012 | 22294269 |
| rna interference in vitro and in vivo using dsirna targeting the nucleocapsid n mrna of human metapneumovirus. | human metapneumovirus causes respiratory diseases with outcomes that can be severe in children, the immunocompromised, and the elderly. synthetic small interfering rnas (sirnas) that silence targeted genes can be used as therapeutic agents. currently, there is no specific therapy for hmpv. in this study, we designed dicer-substrate sirnas (dsirnas) that target metapneumovirus sequences on the mrnas of the n, p, and l genes. in vitro, six dsirnas were shown to inhibit virus replication using cell ... | 2012 | 22285728 |
| human metapneumovirus-associated hospital admissions over five consecutive epidemic seasons: evidence for alternating circulation of different genotypes. | human metapneumovirus (hmpv) is a pathogen of the respiratory tract with a worldwide distribution. the purpose of this study was to identify hmpv as the cause of acute respiratory diseases in children admitted at spedali civili, a public hospital in brescia, italy. eight hundred forty-six nasopharyngeal aspirate samples negative for the presence of other common respiratory viruses were tested for the presence of hmpv rna by reverse transcription-polymerase chain reaction. of the 846 samples, 79 ... | 2012 | 22246840 |
| human metapneumovirus (hmpv) binding and infection are mediated by interactions between the hmpv fusion protein and heparan sulfate. | human metapneumovirus (hmpv) is a major worldwide respiratory pathogen that causes acute upper and lower respiratory tract disease. the mechanism by which this virus recognizes and gains access to its target cell is still largely unknown. in this study, we addressed the initial steps in virus binding and infection and found that the first binding partner for hmpv is heparan sulfate (hs). while wild-type cho-k1 cells are permissive to hmpv infection, mutant cell lines lacking the ability to synth ... | 2012 | 22238303 |
| human metapneumovirus in the cerebrospinal fluid of a patient with acute encephalitis. | to report, to our knowledge, the first case of detection of human metapneumovirus in the cerebrospinal fluid of a patient during acute encephalitis. | 2012 | 22232205 |
| human metapneumovirus in bronchoalveolar lavage fluid of critically ill patients with suspected pneumonia. | | 2012 | 22218810 |
| phylogenetic analysis of human metapneumovirus from new york state patients during february through april 2010. | human metapneumovirus (hmpv) is the second leading cause of lower respiratory infection (lri) in children around the world and has been linked to lri in multiple studies. currently, hmpv is classified into 2 major subtypes (a and b), each with 2 subgroups (1 and 2). | 2012 | 22217900 |
| seasonality of viral respiratory infections in southeast of brazil: the influence of temperature and air humidity. | viruses are the major cause of lower respiratory tract infections in childhood and the main viruses involved are human respiratory syncytial virus (hrsv), human metapneumovirus (hmpv), influenzavirus a and b (flua and flub), human parainfluenza virus 1, 2 and 3 (hpiv1, 2 and 3) and human rhinovirus (hrv). the purposes of this study were to detect respiratory viruses in hospitalized children younger than six years and identify the influence of temperature and relative air humidity on the detected ... | 2012 | 24031808 |
| [observation over three seasons of respiratory syncytial virus infection in a geriatric health service facility]. | to characterize the impact of respiratory syncytial virus (rsv) infection on respiratory illness in a geriatric health service facility. | 2012 | 23459652 |
| human metapneumovirus and respiratory syncytial virus: subtle differences but comparable severity. | human metapneumovirus (hmpv) is a recently discovered virus that causes respiratory illness in children that can lead to hospitalization. our study was undertaken to further understand hmpv-associated illness, compare clinical characteristics of hmpv and respiratory syncytial virus (rsv), and establish the utility of routine screening for hmpv. we retrospectively identified hmpv-associated illnesses described among children with respiratory symptoms admitted to a tertiary care center in southeas ... | 2010 | 24470892 |
| [virology: the contribution of molecular biology in the microbiologic diagnosis of pediatric respiratory diseases]. | the conventionnal tools used for virological diagnosis include direct antigen detection by immunofluorescence (ifa) or an immunoenzymatic test (eia), and viral isolation technique (vit). in most cases, ifa and eia have a slightly lower sensitivity than vit but are also able to detect some vit-negative samples. results of several teams using rt-pcr technologies show that the molecular methods detect more positive cases than the conventional tools. work is under way to expand the number of viruses ... | 2007 | 18280911 |
| simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin. | respiratory viruses of human origin infect wild apes across africa, sometimes lethally. here we report simultaneous outbreaks of two distinct human respiratory viruses, human metapneumovirus (mpv; pneumoviridae: metapneumovirus) and human respirovirus 3 (hrv3; paramyxoviridae; respirovirus, formerly known as parainfluenza virus 3), in two chimpanzee (pan troglodytes schweinfurthii) communities in the same forest in uganda in december 2016 and january 2017. the viruses were absent before the outb ... | 2019 | 30866768 |
| pulmonary function analysis in cotton rats after respiratory syncytial virus infection. | the cotton rat (sigmodon hispidus) is an excellent small animal model for human respiratory viral infections such as human respiratory syncytial virus (rsv) and human metapneumovirus (hmpv). these respiratory viral infections, as well as other pulmonary inflammatory diseases such as asthma, are associated with lung mechanic disturbances. so far, the pathophysiological effects of viral infection and allergy on cotton rat lungs have not been measured, although this information might be an importan ... | 2020 | 32776985 |
| endangered mountain gorillas and covid-19: one health lessons for prevention and preparedness during a global pandemic. | the world's 1063 mountain gorillas (gorilla beringei beringei) live in two subpopulations at the borders of the democratic republic of congo, rwanda, and uganda. the majority of mountain gorillas are human-habituated to facilitate tourism and research, which brings mountain gorillas into close proximity of people daily. wild great apes are proven to be susceptible to human pathogens, including viruses that have caused fatal respiratory disease in mountain gorillas (e.g., human metapneumovirus1 ) ... | 2021 | 34110030 |
| sendai virus-vectored vaccines that express envelope glycoproteins of respiratory viruses. | human respiratory syncytial virus (hrsv), human metapneumovirus (hmpv), and human parainfluenza viruses (hpivs) are leading causes of respiratory disease in young children, the elderly, and individuals of all ages with immunosuppression. vaccination strategies against these pneumoviruses and paramyxoviruses are vast in number, yet no licensed vaccines are available. here, we review development of sendai virus (sev), a versatile pediatric vaccine that can (a) serve as a jennerian vaccine against ... | 2021 | 34072332 |
| human respiratory syncytial virus detected in mountain gorilla respiratory outbreaks. | respiratory illness (ri) accounts for a large proportion of mortalities in mountain gorillas (gorilla beringei beringei), and fatal outbreaks, including disease caused by human metapneumovirus (hmpv) infections, have heightened concern about the risk of human pathogen transmission to this endangered species, which is not only critically important to the biodiversity of its ecosystem but also to the economies of the surrounding human communities. our goal was to conduct a molecular epidemiologic ... | 2020 | 33345293 |