| insulin levels in primates by immunoassay. | only trace amounts of insulin were detected by an immunoassay system with guinea pig antibody to pork insulin in the new world primates cebus and saimiri. the system found insulin levels in the old world primates rhesus and chimpanzee which were quite like those of human beings. the findings suggest important structural differences in the insulins of the two primate divisions. | 1970 | 4989299 |
| immunization against schistosoma japonicum in chimpanzees by administration of x-irradiated cercariae. | | 1970 | 4991944 |
| the laminar distribution of fibers of the corpus callosum: a comparative study in the rat, cat, rhesus monkey and chimpanzee. | | 1970 | 4992846 |
| man, chimpanzee and monkey: a neuropsychological comparison. | | 1970 | 4992853 |
| clinical laboratory studies of the gorilla, chimpanzee, and orangutan. | | 1971 | 4995083 |
| transfer of gonococcal urethritis from man to chimpanzee. an animal model for gonorrhea. | | 1971 | 4996119 |
| hepatitis-associated antigen in chimpanzees. | | 1971 | 4999908 |
| streptokinase and urokinase activation of human, chimpanzee and baboon plasminogen. | | 1971 | 5004225 |
| [evolution of experimental schistosomiasis in chimpanzees: parasitological, radiological, biochemical and pathological aspects]. | | 1971 | 5005064 |
| a re-evaluation of the "nucleus ventralis lateralis" and its cerebellar connections. a study in man and chimpanzee. | | 1971 | 5005457 |
| urinary chorionic gonadotropin in middle and late pregnancy in the chimpanzee. | | 1972 | 5011051 |
| cytotoxicity reactions of chimpanzee antisera with human lymphocyte donors phenotyped or genotyped for hl-a. | | 1972 | 5011648 |
| hl-a antibodies in chimpanzees after specific treatment with human leukocytes and antihuman lymphocyte globulin. | | 1972 | 5011649 |
| cross-reactions between human, chimpanzee, and streptococcal antigens. | | 1972 | 5011651 |
| histocompatibility matching. vii. mixed leukocyte cultures between chimpanzee and man. | | 1972 | 5011652 |
| the histopathology of experimental pinta in the chimpanzee. | | 1972 | 5013604 |
| chimpanzee bipedalism: cineradiographic analysis and implications for the evolution of gait. | bipedal chimpanzees reorient the pelvis to achieve an upright posture but retain the same pattern of femoral flexion and extension as in quadrupedal walking. major differences from human gait are the abducted, relatively more flexed excursion of the femur and the timing of pelvic tilt, which raises during the swing phase. the femoral head morphology in the fossil hominid australopithecus robustus is evidence of an approximately vertical excursion of the femur in contrast to the adducted pattern ... | 1972 | 5085987 |
| running up and down hills: some consequences of size. | small mammals are able to run at about the same maximum speed vertically as horizontally, but larger mammals cannot do this. during level running a mouse weighing 30 grams uses about eight times as much energy per unit of body weight as does a chimpanzee weighing 17.5 kilograms (42.6 joules per kilogram meter versus 5.17 joules per kilogram meter). the additional energy required to lift 1 kilogram of body weight 1 meter while running uphill was similar for the two species (about 15.5 joules per ... | 1972 | 5086836 |
| experimental infection with schistosoma japonicum in chimpanzees. | | 1971 | 5131694 |
| [smallpox in chimpanzees under natural conditions]. | | 1971 | 5137548 |
| experimental infections of the chimpanzee (pan troglodytes) with trypanosoma brucei brucei and trypanosoma brucei rhodesiense. | | 1971 | 5145112 |
| [artificial opening of the occipital foramen magnum in prehistoric man and recent chimpanzees]. | | 1971 | 5154851 |
| serum chemistry in the chimpanzee and the gorilla. | | 1971 | 5157553 |
| transmission experiments with kuru in chimpanzees and the isolation of latent viruses from the explanted tissues of affected animals. | | 1969 | 5257421 |
| [contribution of the side view to the comparative ontogenic study of the head in man and chimpanzees]. | | 1971 | 5282377 |
| artificial feeding of simulium vectors of human and bovine onchoceriasis. | a technique for feeding simuliids artificially in a feeding-tube containing blood covered by a membrane has been developed with a view to studying the development of onchocerca volvulus of man and o. gutturosa of cattle in their respective vectors. a number of different kinds of membranes were tested, but skin from 2-day-old chicks was found to be most satisfactory. s. ornatum, the vector of o. gutturosa in england, fed readily on human and ox blood. the trials were carried out in a constant-tem ... | 1968 | 5303668 |
| leukocytes antigens of chimpanzees and their relation to human hl-a antigens. | | 1970 | 5315612 |
| neuropathological comparisons of experimental kuru in chimpanzees with human kuru. | | 1969 | 5392818 |
| lesions in the central nervous system of a chimpanzee infected with trypanosoma brucei rhodesiense. | | 1970 | 5442035 |
| transmission of plasmodium schwetzi from the chimpanzee to man by mosquito bite. | | 1970 | 5443069 |
| identity of chimpanzee with human fibrinopeptides. | | 1970 | 5461008 |
| cultivation of hepatic tissue from chimpanzees experimentally infected with adenovirus. | | 1970 | 5462569 |
| inoculation pinta in chimpanzees. | | 1970 | 5470080 |
| human streptococcal disease syndrome compared with observations in chimpanzees. ii. immunologic responses to induced pharyngitis and the effect of treatment. | | 1970 | 5504710 |
| suitability and availability of chimpanzees as organ donors for man. | | 1970 | 5521307 |
| severe enterobiasis in a chimpanzee. | | 1970 | 5530017 |
| silent hemoglobin alpha genes in apes: potential source of thalassemia. | small quantities of unusual hemoglobins were found in 1 of 37 chimpanzees and 2 of 6 gorillas. in each genus these hemoglobins contain unique alpha chains that differ from the ordinary by eight to nine scattered amino acid changes. the unusual chains arise from a hitherto undetected hemoglobin (3)alpha locus. no (3)alpha products are found in most apes; accordingly, (3)alpha is considered synthetically inactive in all but a few reversion mutants. indirect evidence that the inactive (3)alpha locu ... | 1971 | 5540329 |
| cardiac depression in the detection of high environmental co2: a comparative study in rhesus monkeys and chimpanzees. | | 1971 | 5541095 |
| relaxing response to transmural stimulation of isolated taenia coli of the chimpanzee and pig. | | 1971 | 5551848 |
| detection of alloantigens on human and chimpanzee skin fibroblasts by in vitro cytotoxicity and colony inhibition tests. | | 1971 | 5568074 |
| experimental toxoplasmosis in chimpanzees. | two chimpanzees were given by mouth large numbers of viable oocysts of toxoplasma gondii obtained from the faeces of experimentally infected cats. before the experiment the first chimpanzee had a positive dye test reaction (1:250), an indication that it had undergone an earlier infection of toxoplasmosis; the serum antibody titres remained unchanged, no evidence of illness was found, and oocysts did not appear in its faeces during the subsequent six weeks. the second chimpanzee showed a negative ... | 1971 | 5575975 |
| studies on infection and immunity in experimental typhoid fever. vii. the distribution of salmonella typhi in chimpanzee tissue following oral challenge, and the relationship between the numbers of bacilli and morphologic lesions. | | 1968 | 5668032 |
| transmission of experimental kuru to the spider monkey (ateles geoffreyi). | clinical signs and pathological changes characteristic of kuru in man and experimental kuru in chimpanzees were observed in two spider monkeys, ateles geoffreyi, after inoculation with brain tissue from a kuru-affected chimpanzee. the incubation period for one of the monkeys was 23 months, and 26 months for the other. | 1968 | 5687819 |
| experimental pinta in the chimpanzee. | | 1968 | 5695667 |
| serologic characterization of adenoviruses isolated from chimpanzees associated with viral hepatitis. | | 1968 | 5696758 |
| irradiated-wallerian degenerated homographs in dogs and chimpanzees. | | 1968 | 5718697 |
| a chimpanzee naturally infected with schistosoma mansoni; its resistance against a challenge infection of s. japonicum. | | 1968 | 5729576 |
| a new simian adenovirus serologically related to human adenovirus type 2 and a chimpanzee with "viral hepatitis". | | 1969 | 5823445 |
| blood group antigens and cross-reacting antibodies in primates including man. iv. the blood factor dc and its relation to the v-a-b blood group system of chimpanzees. | | 1965 | 5843917 |
| studies on infection and immunity in experimental typhoid fever. vi. response of chimpanzees to endotoxin and the effect of tolerance on resistance to oral challenge. | | 1965 | 5845289 |
| blood group antigens and cross-reacting antibodies in primates including man. v. production of antisera for a "new" blood factor v-1 by immunization of chimpanzees with human blood. | | 1965 | 5845410 |
| eye fixation responses to kittens and infant chimpanzees to onset and offset of a stimulus. | | 1965 | 5848942 |
| the inoculation of human leprosy in the chimpanzee initiation of a long-term project. | | 1965 | 5854575 |
| serological interrelationships between human and chimpanzee antisera to primate leucocyte isoantigens. | | 1965 | 5885046 |
| comparative studies of the respiratory functions of mammalian blood. i. gorilla, chimpanzee and orangutan. | | 1966 | 5916542 |
| transmission and passage of experimenal "kuru" to chimpanzees. | | 1967 | 6015529 |
| chimpanzee red cell isoantibody of a "new" specificity, anti-kc, produced by cross-immunization of chimpanzees with human blood. | | 1967 | 6024979 |
| comparison of antigenic and chemical similarities between vitamin b 12-binders of human gastric juice and vitamin b 12-binders extracted from the mucosa of chimpanzee (pan troglodytes) stomach. | | 1967 | 6052502 |
| discussion on kuru, scrapie and the experimental kuru-like syndrome in chimpanzees. | | 1967 | 6069978 |
| cyclically transmitted infections of trypanosoma brucei, t. rhodesiense and t. gambiense in chimpanzees. | | 1967 | 6080668 |
| an affordable multideterminant plasma-derived hepatitis b virus vaccine. | a new vaccine is reported which contains hepatitis b virus (hbv) e antigen (hbeag) and pre-s determinants, in addition to highly purified hbv surface antigen (hbsag). the rationale for this approach depends on the following data indicating that anti-hbe and antibody to the core antigen (anti-hbc), and antibody to pre-s determinants may play an active role in preventing hbv infection: (1) active immunization of chimpanzees with hbeag(s) devoid of detectable hbsag protected against subsequent chal ... | 1984 | 6085626 |
| leads from the mmwr. experimental infection of chimpanzees with lymphadenopathy-associated virus. | | 1984 | 6086967 |
| experimental infection of chimpanzees with lymphadenopathy-associated virus. | | 1984 | 6087107 |
| hepatitis b virus transcription in the infected liver. | hepatitis b virus (hbv) transcription was studied in the liver of an infected chimpanzee and compared with hbv transcription in heterologous systems. besides the well characterized 2.3-kb surface antigen mrna produced in most systems, a second major transcript was identified in the liver. this 3.8-kb transcript (+/- 300 bases) is slightly larger than the hbv genome and is probably involved both in core/e antigen synthesis and in hbv replication via reverse transcription. in addition, minor varia ... | 1984 | 6092066 |
| transmission of htlv-iii infection from human plasma to chimpanzees: an animal model for aids. | two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (aids) or pre-aids showed serum antibodies to type iii human t-cell leukemia virus (htlv-iii) 10 to 12 weeks after transfusion. one animal also developed lymphadenopathy, transient depression of the ratio of t4 to t8 lymphocytes, and impaired blastogenic responses. no opportunistic infections occurred. adenopathy persisted for 32 weeks, and antibody to htlv-iii persisted for at least 48 weeks. this trans ... | 1984 | 6093251 |
| [viral hepatitis a and b in anthropoid apes of the moscow zoo]. | the rate of occurrence of hepatitis a and b virus specific markers in anthropoid apes of the moscow zoo (3 chimpanzees, 3 gorillas, 8 orang-outangs) was studied. long-term persistence of hbs-antigen in orang-outang accompanied by the presence of hbe-antigen and anti-hbs was demonstrated. the presence of anti-hbs in gorillas and orang-outangs was recorded. antibodies to hepatitis a virus were found in all the animal species examined. cases of acute virus hepatitis a in orang-outangs are described ... | 1984 | 6093384 |
| initial characterization of four cytomegalovirus strains isolated from chimpanzees. brief report. | cytomegalovirus was isolated from chimpanzees. the chimpanzee cmv showed a strong antigenic relationship with human cmv. the genome of the chimpanzee cmv was found to have a molecular weight of 147 +/- 11.3 x 10(6) and showed partial homology to human cmv dna. | 1984 | 6093744 |
| primate animal models and titered inocula for the study of human hepatitis a, hepatitis b, and non-a, non-b hepatitis. | although many primate species have been inoculated with the agents of human hepatitis a, b, and non-a, non-b, only a small number of species have been shown to be susceptible, and only the chimpanzee (pan troglodytes) has been shown to be reproducibly susceptible to all three types of human hepatitis. infectious inocula containing each agent have been identified in different laboratories and the end-point titers of infectivity determined, in most cases by inoculation of chimpanzees. these inocul ... | 1983 | 6094814 |
| predisposition to invasive pneumococcal illness following parainfluenza type 3 virus infection in chimpanzees. | an outbreak of invasive disease, including pneumococcal bacteremia, meningitis, and pneumonia, involved 17 of 83 (20.5%) chimpanzees at a primate rehabilitation unit. invasive disease was more common in splenectomized than in nonsplenectomized animals (42.9% vs 18.4%), but the difference was not statistically significant. the outbreak followed closely an outbreak of upper respiratory tract infection (urti) that occurred with equal frequency in splenectomized and nonsplenectomized chimpanzees. th ... | 1984 | 6096328 |
| hepatitis a virus: growth characteristics of in vivo and in vitro propagated wild and attenuated virus strains. | serial passage of the ms-1 strain hepatitis a virus (hav) in marmosets was shown to increase the yield of virus and to shorten the incubation period from approximately 55 days in the first passage to 3-7 days in the ninth and higher passages. intravenous inoculation of susceptible chimpanzees with ms-1 hav was found to result in a typical course of disease in two animals who had received eighth marmoset-passage virus, including the occurrence of elevated alt activity, presence of hav antigen in ... | 1984 | 6096505 |
| isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee. | the beta-globin gene cluster of human, gorilla and chimpanzee contain the same number and organization of beta-type globin genes: 5'-epsilon (embryonic)-g gamma and a gamma (fetal)-psi beta (inactive)-delta and beta (adult)-3'. we have isolated the psi beta-globin gene regions from the three species and determined their nucleotide sequences. these three pseudogenes each share the same substitutions in the initiator codon (atg----gta), a substitution in codon 15 which generates a termination sign ... | 1984 | 6098690 |
| control of adrenal androgen production. | the major adrenal androgens are dehydroepiandrosterone (dhea), dehydroepiandrosterone sulphate (dheas) and androstenedione (delta 4). studies by cutler et al in 1978 demonstrated that these androgens are detectable in blood of all domestic and laboratory animals studied, but that only 4 species show increase in one or more with sexual maturation: rabbit, dog, chimpanzee and man. studies by grover and odell in 1975 show these androgens do not bind to the androgen receptor obtained from rat prosta ... | 1984 | 6100259 |
| removal of hepatitis-b-virus infectivity from factor-ix complex by hepatitis-b immune-globulin. experiments in chimpanzees. | hepatitis-b-virus infectivity can be removed from a heat-labile clotting factor concentrate by the addition of hepatitis-b immune-globulin. three chimpanzees were each inoculated with samples of factor-ix complex (factor ix) which had been deliberately contaminated with 10(3.5) chimpanzee infectious doses of hepatitis-b virus from a known infectious inoculum. two of these factor ix samples had been incubated with hepatitis-b immune-globulin after the addition of hepatitis-b virus. 10 weeks after ... | 1980 | 6105247 |
| formation and urinary excretion of cyproheptadine glucuronide in monkeys, chimpanzees, and humans. | the urinary excretion of cyproheptadine glucuronide (a quaternary ammonium glucuronide) was studied in monkeys, chimpanzees, and humans after a single 5-mg oral dose of cyproheptadine. humans and chimpanzees excreted, over a 48-hr period, an average 12.4 and 8.6% of the dose, respectively, as cyproheptadine glucuronide. various species of monkeys excreted less than 0.5% of the dose as the quaternary ammonium glucuronide conjugate. according to these and previously published data, these unusual d ... | 1980 | 6109610 |
| experimental non-a, non-b hepatitis: four types of cytoplasmic alteration in hepatocytes of infected chimpanzees. | on the occasion of an outbreak of non-a, non-b hepatitis in a plasmapheresis centre (81 cases, incubation period: 3--6 weeks) a pool of 12 plasma samples was obtained in the early phase of increasing transaminases. two chimpanzees were inoculated, each receiving 12 ml of the pooled plasma. after an incubation period of 10--12 weeks a mild non-a, non-b hepatitis developed. serum transaminases were slightly elevated. needle biopsies, taken fortnightly, showed a slight activation of kupffer cells ( ... | 1980 | 6110271 |
| the major histocompatibility complex of primates: evolutionary aspects and comparative histogenetics. | all mammalian species investigated have a chromosomal region designated as the major histocompatibility complex or m.h.c. the biological significance of the m.h.c. goes far beyond controlling the most important histocompatibility or transplantation antigens; the capacity to respond immunologically, the susceptibility to disease (including cancer), the serum level of several complement factors and numerous other biological traits are regulated by genetic systems closely linked within that chromos ... | 1981 | 6115401 |
| broca's area and the origins of human vocal skill. | chimpanzees appear to be unable to learn to speak. it is usual to attribute their lack of vocal skill to limitations of their vocal tract, and to the absence in their neocortex of any area corresponding to broca's area in the human brain. the first signs of broca's area in hominid endocasts are therefore taken to represent an evolutionary development of great significance. there are two outstanding questions. first, what exactly does broca's area do? secondly, why does broca's area in one hemisp ... | 1981 | 6115406 |
| mycoplasma colonization in primate animal laboratories. | the role of bacterial and protozoal infections in reproductive failure and fetal loss has been difficult to establish in humans. this study was done in 78 female primates to determine if ureaplasma urealyticum was present. the highest overall incidence of positive cultures (36.4%) occurred among the chimpanzees, who also had the highest number of breeders (i.e., sexually active females.) this suggests that the organisms may be transmitted sexually. an opportunity is now available to study the ro ... | 1982 | 6127254 |
| human monkeypox transmitted by a chimpanzee in a tropical rain-forest area of zaire. | a case of monkeypox infection in a six-month-old baby girl who had been bitten by a wild chimpanzee in kivu, zaire, was investigated. the child had not been exposed to any monkeypox-like disease and no cases of such disease had occurred in the surrounding area during previous months. the time of onset of rash was consistent with the virus having been transmitted from the chimpanzee. however, it is still not known whether chimpanzees and other primates or lower mammals are the primary reservoir o ... | 1983 | 6132084 |
| human monkeypox transmitted by a chimpanzee. | | 1983 | 6133144 |
| serum dopamine beta-hydroxylase activity in non-human primates: phylogenetic and genetic implications. | 1. serum dopamine beta-hydroxylase (dbh) activity is one to two orders of magnitude higher in man than in any other species previously studied. the high levels of human serum dbh are associated with the inherited allele dbhh. 2. dbh activity was measured in serum from gorillas, chimpanzees, orangutans, gibbons, rhesus monkeys and squirrel monkeys in an attempt to determine how recently in the course of evolution the allele dbhh had originated. 3. of the non-human primates tested, only gorillas h ... | 1983 | 6135564 |
| morphology of primate's dopaminergic amacrine cells as revealed by th-like immunoreactivity on retinal flat-mounts. | dopaminergic (da) cells have been revealed by immunohistochemical localization of tyrosine hydroxylase in the retina of cynomolgus monkey, chimpanzee and human. the da neurons were visualized in cross-sections as well as in flat-mounts of retina. the comparison revealed a striking morphological similarity between the da neurons in the three species. when observed in flat-mounts, they were of stellate type; when observed in cross-sections, except for a few displaced cells, they were unistratified ... | 1984 | 6143588 |
| ultrastructural alterations in serial liver biopsy specimens from chimpanzees experimentally infected with a human non-a, non-b hepatitis agent. | four chimpanzees experimentally infected with an agent of human non-a, non-b hepatitis were studied to determine the sequence of ultrastructural alterations in hepatocytes during infection. three of the four types of cytoplasmic alterations previously described in association with non-a, non-b hepatitis were observed in the hepatocytes. sponge-like cytoplasmic inclusions (designated c-i) were detected at or near the time of peak serum aminotransferase elevations in two of the four chimpanzees. u ... | 1984 | 6146221 |
| long-term sequelae of non-a, non-b hepatitis in experimentally infected chimpanzees. | we have observed the development of long-term sequelae in four cases of experimentally induced non-a, non-b (nanb) hepatitis in chimpanzees. these sequelae were characterized by the following manifestations: nonprotection against challenge with autologous infectious plasma following acute disease and subtle histopathological alterations typical of long-lasting viral hepatitis. these manifestations were observed in animals infected with either of two human inocula. whether or not these inocula re ... | 1984 | 6148298 |
| evolution of butyrylcholinesterase in higher primates: an immunochemical study. | serum butyrylcholinesterase (buche; ec 3.1.1.8) of man and the higher primates was tested enzymatically and immunochemically, with the aid of monoclonal antibodies (mcab) developed against the enzyme isolated from human blood. enzyme activities showed great differences across species and among individuals, but all samples tested were dibucaine-sensitive. one mcab showed similar affinities for buche of each species, but another showed marked differences in affinity, preferring species in the orde ... | 1984 | 6149875 |
| isolation of a virus from chimpanzee liver cell cultures inoculated with sera containing the agent of non-a, non-b hepatitis. | a membrane-coated virus having a diameter of 85-90 nm and containing a 40-45 nm core was found to replicate in cell cultures derived from chimpanzee liver after inoculation of serum containing infective non-a, non-b (nanb) hepatitis viruses from two independent sources. replication of this agent was not observed when the same cells were inoculated with a chloroform-extracted inoculum or were left uninoculated. replication involves assembly of virus cores on tubular structures similar to those se ... | 1984 | 6150143 |
| infection of chimpanzees with lymphadenopathy-associated virus. | | 1984 | 6150305 |
| two low molecular weight peptides as common determinants to different molecular forms and specificities of hepatitis b e antigen (hbeag). | two fractions, i and ii, corresponding to heavy and light molecular forms of hbeag and respectively associated with the (hbe/1 + hbe/2) and (hbe/3) specificities, were separated by ammonium sulfate precipitation in hbeag positive chimpanzee plasma. i 125-labeling of fractions i and ii and immune precipitation by anti-hbe and anti-human igg were followed by autoradiographic analysis after sds polyacrylamide gel electrophoresis: this revealed that two small peptides (a major 17,000 mw and minor 21 ... | 1980 | 6155438 |
| non-satellite repetitive human dna families. sequence properties and evidence for occurrence in chimpanzee dna. | repetitive human dna, fractionated on cscl gradients following hydroxyapatite isolation, contains two complex dna fractions, the 1.703 and 1.714 dna families (marx, k.a., allen, j.r. and hearst, j.e. (1976) biochim. biophys. acta 425, 129-147). biphasic topt profiles, obtained in dna excess hybridizations with crna tracers from each dna family, have been shown to be the likely result of a fast kinetic component hybridizing at higher temperatures (67 degrees c peak) and this fast plus a slow kine ... | 1980 | 6156704 |
| comparisons of nuclear antigens of epstein-barr virus (ebv) and ebv-like simian viruses. | nuclear antigens (na) of ebv (ebna), herpesvirus gorilla, h. papio, h. pongo and h. pan were tested with sera of human, gorilla, chimpanzee, orangutan, gibbon and baboon origins. both conventional anticomplement immunofluorescence (acif) and acid-fixed nuclear binding of antigen followed by acif (afnb) procedures were used. comparisons of antibody titres by acif and afnb suggested that human sera detected the same antigenic determinants on ebna by the two procedures but gorilla sera measured dif ... | 1980 | 6156993 |
| plc/prf/5 (alexander) hepatoma cell line: further characterization and studies of infectivity. | the alexander hepatoma cell line, plc/prf/5, was studied for evidence of hepatitis b virus markers and alpha-fetoprotein. only hepatitis b surface antigen and alpha-fetoprotein were detected. induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did not reveal evidence of synthesis of additional hepatitis b virus markers or of production of infectious virus. | 1980 | 6160110 |
| investigations on the chromosomal localizations of the human and chimpanzee interferon genes: possible role of chromosomes 9 and 13. | analysis of a great number of independent hamster-human and mouse-chimpanzee somatic cell hybrid clones confirms the role of chromosome 9 as carrying one or more primate beta interferon genes. the presence of chromosome 13 in producing hybrids and its absence in all non producing clones must be kept in mind for future studies. the strong negative regulation of interferon production in the parental hamster cells also affects the human gene product. the uv irradiation target for these regulatory g ... | 1980 | 6164335 |
| current knowledge of the d/dr region of the major histocompatibility complex of rhesus monkeys and chimpanzees. | | 1980 | 6167550 |
| immunological relationship among adenoviruses of humans, simians, and nonprimates as determined by the neutralization test. | 98 antisera prepared against 25 simian adenoviruses and 31 adenovirus types from various nonprimate mammals and birds were tested for their ability to neutralize 35 human adenovirus prototypes. antisera to these human adenovirus types were similarly tested against 25 simian adenovirus prototypes. although very few reactions to the human adenoviruses were found in antisera to nonprimate viruses, cross-reactions among the simian and human adenoviruses were more frequent. the majority of these reac ... | 1981 | 6168602 |
| the antibody response to myoglobin is independent of the immunized species. analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species. | the recent determination of the entire antigenic structure of sperm-whale myoglobin with rabbit and goat antisera has permitted the examination of whether the antigenic structure recognized by antibodies depends on the species in which the antisera are raised. also, by knowledge of the antigenic structure, the molecular factors that determine and influence antigenicity can be better understood in terms of the effects of amino acid substitutions occurring in the antigenic sites and in the environ ... | 1980 | 6169338 |
| light microscopic localization of hepatitis b virus antigens in the human pancreas. possibility of multiplication of hepatitis b virus in the human pancreas. | hepatitis b virus has been considered to be strictly organotropic and to infect and multiply only the hepatocytes of humans and chimpanzees. the localization of hepatitis b surface antigen in extrahepatic tissues has been regarded as due to deposition or phagocytosis of hepatitis b surface antigen circulating in the blood. in the present study, however, we demonstrated hepatitis b virus antigens in the pancreases of autopsied subjects with hepatitis b surface antigenemia by shikata's orcein stai ... | 1981 | 6169587 |
| antiviral treatment of chronic hepatitis b virus infection: infectious virus cannot be detected in patient serum after permanent responses to treatment. | fourteen chimpanzees were inoculated with pre- and posttreatment sera from seven patients with persistent hepatitis b virus infection and chronic hepatitis who had permanent responses of their infection to treatment with interferon and/or adenine arabinoside. inoculation of pretreatment serum at a dilution of 10(-8) from a patient with a type i response to treatment [disappearance of dane particle dna polymerase (dnap) activity, hbeag, and hbsag from serum] resulted in infection, while undiluted ... | 1982 | 6172352 |
| human b cell alloantigens: expression of mb and mt determinants. | four hla-dr-homozygous cell lines were examined in detail to compare alpha and beta subunits precipitated by chimpanzee antisera and alloantisera directed against hla-dr, mb, or mt determinants. for the hla-dr5-homozygous cell line sweig, chimpanzee antisera directed against mt2 and against the hla-dr5 specificity yielded identical patterns. similar findings for mt and mb vs hla-dr were obtained for the cell lines lg14 (hla-dr3-homozygous), pbur (hla-dr7-homozygous), and eld (hla-drw6-homozygous ... | 1982 | 6174619 |
| monoclonal antibodies as a tool for phylogenetic studies of major histocompatibility antigens and beta 2-microglobulin. | the cross-reactivity of several monoclonal antibodies recognizing monomorphic determinants of human hla-a, b, c, and dr antigens and human beta 2-microglobulin (beta 2m) has been studied on peripheral blood leukocytes in 24 different species. an monoclonal hla-a-, b-, and c-specific antibody and four monoclonal hla-dr-specific antibodies cross-reacted with cells from all the primate species tested. furthermore, antibodies hla-dr-specific were positive with peripheral blood leukocytes (pbl) from ... | 1982 | 6176537 |
| amylase levels in the tissues and body fluids of several primate species. | 1. serum amylase levels in the gorilla, orang-utan, chimpanzee and squirrel monkey are similar to man. serum amylase in the rhesus macaque is almost a whole order of magnitude higher than man. 2. of the several species tested, all have appreciable amylase in saliva or the parotid gland except the squirrel monkey. 3. high levels of amylase were found in the pancreas of all species tested. amylase was found in the livers of all species tested. 4. in in vivo experiments with squirrel monkeys, injec ... | 1982 | 6178549 |