| percutaneous absorption of testosterone in the newborn rhesus monkey: comparison to the adult. | percutaneous absorption of testosterone was determined in newborn rhesus monkeys, an animal model which is relevant to man. mean percentage of absorptions of 4 and 40 microng/cm2 in the newborn were, respectively, 22.5 +/- 2.2 (sd) and 6.8 +/- 2.1. statistical comparisons (student's t-test) of these results with those obtained with adults show no significant difference (p greater than 0.05) in skin penetration of testosternoe in newborn and adult rhesus monkeys. in the newborn, the efficiency of ... | 1977 | 405649 |
| radioimmunoassay of a human serum growth factor for balb/c-3t3 cells: derivation from platelets. | a radioimmunoassay has been developed for the detection and quantification of a human serum polypeptide that has growth-promoting activity for confluent balb/c-3t3 cells. antiserum to this growth factor does not recognize antigens in mouse, guinea pig, or bovine serum but does detect some crossreacting antigen in the serum of the new world monkey cebus albifrons and more in the serum of the old world rhesus monkeys macaca mulatta and m. fascicularis, demonstrating that the antigenic determinants ... | 1977 | 405669 |
| failure of copulation to affect serum prolactin, lh, and estrogen levels in female rhesus monkeys. | | 1977 | 405676 |
| ultradian rhythms in hand-mouth behavior of the rhesus monkey. | | 1977 | 405694 |
| attempts to immunize monkeys against plasmodium knowlesi by using heat-stable, serum-soluble antigens. | thirty-six macaca mulatta monkeys were immunized with different concentrations and regimens of heat-stable, serum-soluble (s-) antigens of plasmodium knowlesi prior to challenge with the homologous parasite via sporozoite inoculation. fewer deaths and reduced maximum parasitemias occurred in those animals inoculated with 10 to 40 mg of s-antigen compared to nonimmunized monkeys or those receiving only freund's adjuvant. protection was incomplete, however, suggesting that atibodies to s-antigens ... | 1977 | 405876 |
| chronic methylmercury exposure in the monkey (macaca mulatta). behavioral test of peripheral vision, signs of neurotoxicity, and blood concentration in relation to dose and time. | small daily doses of methylmercury hydroxide were administered to rhesus monkeys for periods of up to 17 months. behavioral tests of peripheral vision and of the accuracy and rapidity of hand movements did not disclose any early subtle deficits preceding the onset of obvious signs of neurotoxicity. these signs appeared suddenly and involved reduced food intake (anorexia), clumsiness of jumping, loss of fine control of the digits, and uncoordinated mastication. with a constant daily dose of 0.1 m ... | 1977 | 405934 |
| [cytological structure of the thymus gland in mature monkeys]. | histological sections of the thymus were studied morphometrically in 5 rhesus monkeys and 3 hamadryas baboons. the ratio of square surfaces of the cortical and cerebral substance, the percentage of hassall's corpuscles and cellular elements (lymphocytes, stromal elements, blasts etc.) were established in the organ. individual and species peculiarities of the structure of thymus elements were found. less amount of parenchyma and growth of the stroma in baboons and a greater mitotic complex in rhe ... | 1977 | 405958 |
| form deprivation without light deprivation produces the visual deprivation syndrome in macaca mulatta. | the previously reported arrest of cell growth in the lateral geniculate nucleus (lgn) following unilateral lid suture during visual immaturity in cats, dogs and monkeys could be caused by deprivation of light or form vision, binocular interaction or a combination of these factors. the lens was surgically removed from one eye of 3 macaques during the first month of life. quantitative histologic comparison between lgn laminae connected with the phakic and aphakic eye revealed reductions of cell si ... | 1977 | 406013 |
| c3b receptors in glomerular disease. | using two indicator systems--sheep erythrocytes or fluoresceinated s. typhi coated with c3b the presence of a receptor for c3b (but not c3d) in the normal human glomerulus is confirmed. no receptor could be detected in other species tested (mouse, rat, guinea-pig, rabbit and rhesus monkey). binding of indicator particles was reduced or lost in diseases associated with glomerular capillary deposition of c3, but not in those with mesangial deposition alone. however in some cases the receptor was l ... | 1977 | 406109 |
| placental and nonplacental drainage of the uterus in the pregnant rhesus monkey. | | 1977 | 406148 |
| a chronic gastrostomy and test system for evaluation of gastric secretions in rhesus monkeys. | we have developed a test system for the evaluation of gastric secretion in the rhesus monkey on a chronic basis that does not require the usual restraining techniques. the system is characterized by ease of animal maintenance and handling, reliability in introducing test substances into the stomach, and long term postsurgical stability. the system comprises a surgical preparation whereby the gastrostomy tube is inserted permanently in the stomach, is passed subcutaneously up the back, and is ext ... | 1977 | 406159 |
| physiological effects of laser trabeculotomy in rhesus monkey eyes. | | 1977 | 406214 |
| the effect of mannitol infusion on retinal function and oxygen tension. | mannitol administered intravenously in rhesus monkeys resulted in a temporary recovery of the visual evoked response (ver) after its decrease due to elevation of the intraocular pressure. mannitol infusion caused an immediate, albeit transitory, increase in retinal oxygen tension. these changes were independent of the ocular hypotensive effect of mannitol, and we conclude that the drug is a far better agent for the treatment of acute glaucoma than heretofore believed. | 1977 | 406217 |
| social and nonsocial behaviors of adult rhesus monkeys after amygdalectomy in infancy or adulthood. | at 6 yr of age six female rhesus monkeys that had sustained bilateral amygdalectomy in infancy, and five intact controls, were transferred to an observation cage where behaviors were recorded while the monkeys were (a) alone, (b) paired with unfamiliar stimulus animals, and (c) paired with familiar monkeys from the opposite experimental group. the five adult controls then underwent amygdalectomy, and all tests were repeated with the infant- and adult-operated animals. infant-operated monkeys cha ... | 1977 | 406291 |
| airway mucosal permeability in the ascaris suum-sensitive rhesus monkey. | the permeability of the airways to technetium 99m-labeled albumin was measured in ascaris suum-sensitive rhesus monkeys. all 8 animals were skin-sensitive to ascaris suum (aa) antigen, 4 being respiratory responders (r) and 4 nonresponders (nr) to aerosolized antigen. in the absence of antigen challenge there were no differences in the accumulation in the blood of radioactive material from the tracheobranchial tree between the r and nr animals. after a five-minute challenge with aerosolized aa, ... | 1977 | 406301 |
| genetic polymorphism of the sixth component of complement (c6) in the rhesus monkey. | with isoelectric focusing, the complement protein c6 has been shown to be genetically polymorphic in the rhesus monkey. three codominant alleles of a single autosomal locus, rh c6, have been recognized: c6a, c6b, and c6r, with gene frequencies of 0.592, 0.354, and 0.053 in a random rhesus monkey population. hardy-weinberg analysis of the phenotypic frequencies in this population yielded observed values very close to those expected. both natural mating between individuals carrying the various all ... | 1977 | 406324 |
| effect of pge1 on immediate-type immunologic and pharmacologic respiratory responses of the rhesus monkey. | the effect of prostaglandin (pg)e1 on the acute, immediate-type airway response to antigen, carbocholine, pgf2alpha, histamine, and physostigmine was studied. in contrast to isoproterenol, which affects all abnormalities of pulmonary function, pge1 selectively reversed only abnormalities of pulmonary resistance and dynamic compliance. prior exposure to pge1 minimally inhibited airway responses but when given simultaneously with antigen, it either selectively inhibited some or dampened all pulmon ... | 1977 | 406337 |
| dengue viruses and mononuclear phagocytes. i. infection enhancement by non-neutralizing antibody. | cultured mononuclear peripheral blood leukocytes (pbl) from nonimmune human beings and monkeys are nonpermissive to dengue 2 virus (d2v) infection at multiplicities of infection of 0.001-0.1, but become permissive when non-neutralizing dengue antibody is added to medium. d2v infection occurred in pbl prepared from anti-coagulated but not from defibrinated plasma. infection enhancement was produced by multiple lots of heterotypic anti-dengue raised in several mammalian species. homotypic anti-den ... | 1977 | 406347 |
| time-dependent kinetics i: exponential autoinduction of carbamazepine in monkeys. | the pharmacokinetics of carbamazepine were studied during a week-long infusion of the drug in 60% polyethylene glycol 400 solution in three rhesus monkeys. serum concentrations approached steady state within 8-16 hr and then rapidly declined, within 72 hr, to a new asymptotic level approximately 46% of the maximum steady-state concentration. serum concentrations remained at that level during the rest of the experimental period. the decline from the maximum value to the asymptotic steady state wa ... | 1977 | 406378 |
| time-dependent kinetics ii: diurnal oscillations in steady-state plasma ethosuximide levels in rhesus monkeys. | morning steady-state (9 am) plasma levels were significantly higher than the corresponding evening (5 pm) plasma levels during a 3-week zero-order infusion of ethosuximide to six monkeys. these differences could not be explained by experimental variables such as glc assay and infusion pump. circadian periodicity in steady-state plasma levels was investigated in three monkeys over 4 months under controlled experimental conditions: blood sampling at 2-hr intervals for 26 hr, 1 day/week; fixed ligh ... | 1977 | 406379 |
| aldosterone antagonism studies in the rhesus monkey. | renal studies in femal rhesus monkeys indicated that 10 micron g was an optimum i.m. sodium-retaining dose of aldosterone. aldosterone was injected i.m. at dosages of 2.5, 5, 10 and 20 micron g/animal. the 10-micron g dose induced about a 50% reduction in sodium excretion (from 3.7 to 1.7 meq/6 hr) and was selected as the standard dose for antagonism studies. k excretion and urine volume remained unchanged. subsequently, the oral antialdosterone activities of spironolactone and canrenone, a delt ... | 1977 | 406381 |
| blood groups of crab-eating macaques (macaca fascicularis) demonstrated by isoimmune rhesus monkey (macaca mulatta) sera. | twenty-one isoimmune sera produced in rhesus monkey (macaca mulatta) containing type-specific antibodies for simian-type red cell antigens were tested for their cross-reactivity with red cells from crab-eating macaques (m. fascicularis). the majority of the antisera gave cross-reactions determining polymorphisms in the red cells of crab-eating macaques, homologous to those of rhesus monkeys. these results attest to the close taxonomic realationship between the two species of macaques, and have t ... | 1977 | 406404 |
| immunogenetic studies on the rhesus monkey (macaca mulatta): xi use of blood groups in problems of parentage. | a battery of 21 alloimmune blood typing reagents was developed and used for resolving cases of disputed parentage in the rhesus monkey (macaca mulatta). using these reagents, the breeding records of a large colony of rhesus monkeys were monitored. among 1263 complete families typed, 46 (3.6%) disputed parentage cases were discovered by excluding an assigned parent. of these disputed parentage cases, 76% were resolved and the most probable parents assigned. in addition, the paternity of 63% of th ... | 1977 | 406479 |
| accidental methyl methacrylate inhalation toxicity in a rhesus monkey (macaca mulatta). | a rhesus monkey (macaca mulatta), accidentally exposed to vapors of methyl methacrylate for 22 hours was found in a comatose condition. attempts to revive the animal were unsuccessful. necropsy revealed a diffusely mottled liver, pulmonary edema, and atelectasis. the thoracic cavities each contained 30 ml of clear yellow fluid. histopathologic review of the tissues showed central lobular liver necrosis, pulmonary edema, pulmonary emphysema, and atelectasis. analysis of a blood sample obtained fr ... | 1977 | 406481 |
| some factors influencing the effects of temporary mother-infant separation: some experiments with rhesus monkeys. | some experiments, reported in detail elsewhere, on the effects of mother-infant separation in rhesus monkeys are here reviewed and compared. they involved 4 groups--one in which mothers were removed for 13 days leaving the infant in the social group; one in which infants were removed; one in which mothers and infants were removed and separated; and one in which mothers and infants were removed but not separated. the nature of separation experience had a profound effect on the infant's response: ... | 1977 | 406620 |
| bacteriophages in live virus vaccines: lack of evidence for effects on the genome of rhesus monkeys. | four juvenile rhesus monkeys were inoculated with 10(12) plaque-forming units of the bacteriophage phiv1 isolated from live virus vaccines. after phiv1 had been cleared from the blood, dna's were isolated from the livers and kidneys and analyzed for the presence of bacteriophage by plaque assays, and for the presence of phiv1 dna by dna-dna reassociation kinetics. no evidence was found for persistence of the bacteriophage or for replication of the phage genome in these rhesus monkeys. | 1977 | 406673 |
| trabecular damage due to blunt anterior segment injury and its relationship to traumatic glaucoma. | gonioscopy, performed within 48 hours of traumatic hyphema, revealed not only angle recession but also a high incidence of damage to the trabecular meshwork and the schlemm canal. these trabecular lesions tend to scar and become much more difficult to recognize over the ensuing weeks. large tears into the ciliary body (angle recession) also had a tendency to "close." using a specially calibrated bb gun hyphema was induced in rhesus monkeys. trabecular tears were recognized by gonioscopic and his ... | 1977 | 406709 |
| placental transfer of glucose-amino acid complexes present in parenteral solutions. | intravenous infusion of glucose-amino acid complexes, formed during heat sterilization of mixtures of glucose and amino acids or protein hydrolysates, has been associated with mild dehydration in infants, and with excessive trace metal ion excretion in both infants and adults. when parenteral solutions containing these glucose-amino acid complexes were infused into pregnant rhesus monkeys, the compounds accumlated in the maternal plasma and were transported to the fetal circulation. although all ... | 1977 | 406775 |
| the effect of marihuana (delta-9-tetrahydrocannabinol) on the secretion of luteinizing hormone in the ovariectomized rhesus monkey. | despite the widespread use of marihuana by large numbers of young adults in the reproductive years, little is known about the effects of this drug on reproductive function. information on the effect of the drug on the woman is particularly meager. the rhesus monkey provides an excellent animal model from which to generalize to man. while the primary purpose of the project is to determine the effect of long-term administration on the cycling female monkey, the initial studies were carried out in ... | 1977 | 406789 |
| effect of antrectomy on gastric hypersecretion induced by distal small bowel resection. | seven male rhesus monkeys, with demonstrated gastric hypersecretory response to 50% distal small bowel resection, were studied. this increase in gastric acid output had persisted for more than 6 months. precise, anatomical antrectomy without vagotomy was performed and intestinal continuity restored by gastroduodenostomy. complete abolition of basal acid secretion and of the secretory response to histamine occurred. these effects could not be reversed by continuous (5 hour) infusions of pentagast ... | 1977 | 406866 |
| [experiments on rhesus-monkeys (macaca mulatta) with the carcinogens methyl- and ethylnitrosourea (author's transl)]. | application of methyl- and/or ethylnitrosourea during intrauterine or postnatal life did not induce tumours in macaca mulatta. most of the animals survived 5 to 10 years after the beginning of the experiments and are in good health at present. complete postmortem examinations were performed in all monkeys who died. | 1977 | 406876 |
| optic disc edema in raised intracranial pressure. i. evolution and resolution. | progressively growing intracranial space-taking lesions were simulated in 32 rhesus monkeys by balloons introduced into the subarachnoid space of the temporal region. optic disc edema (ode) first appeared at the lower pole, then the upper pole, then the nasal part, and last the temporal part of the disc; severity of edema generally followed sult, most severe at the lower pole (p less than .005). fluorescein fundus angiography showed that swelling of the optic disc preceded the vascular changes a ... | 1977 | 406882 |
| optic disc edema in raised intracranial pressure. ii. early detection with fluorescein fundus angiography and stereoscopic color photography. | optic disc edema (ode) due to chronic intracranial hypertension was produced experimentally in rhesus monkeys. serial studies of fundus changes at frequent intervals, by routine ophthalmoscopy, steroscopic color photography, and fluorescein angiography, revealed that swelling of the optic disc was the first sign of ode. other early signs were striation of nerve fibers on the optic disc margins and peripapillary retina, blurring of the disc margins, hyperemia of the disc and capillary dilation, h ... | 1977 | 406883 |
| fluorescein angiography and light microscopy studies of retinas irradiated by oxygen nuclei. | fluorescein angiography and light microscopy techniques were utilized in the rhesus monkey to evaluate retinal damage following oxygen ion irradiation. particle flux ranged from 1.3 x 10(7) particles/cm2 to 1.5 x 10(8) particles/cm2. earliest evidence of damage was detected with fluorescein angiograms 24 h after exposures to 7.7 x 10(7) particles/cm2. no evidence of the hypothesized microlesion was found by either technique. | 1977 | 406890 |
| relative biological effectiveness (rbe) of heavy ions (o+8) for producing retinal lesions. | the relative biological effectiveness (rbe) for oxygen ions (250 mev/nucleon) for producing an ischemic retinal lesion in the rhesus monkey has been shown to be greater than 10. the rbe concept and the use of the standard methodology is discussed with respect to other published reports. | 1977 | 406891 |
| vascular dynamics of the reproductive tract in the female rhesus monkey: relative contributions of ovarian and uterine arteries. | | 1977 | 406940 |
| toxicity of 2,3,7,8-tetrachlorodibenzo-p-diozin for rhesus monkeys: brief report. | | 1977 | 406953 |
| activity of neurones in the inferotemporal cortex of the alert monkey. | the activity of neurones in the inferotemporal cortex of the alert rhesus monkey was recorded while the monkey was shown visual stimuli, which included both food and non-food objects for comparison with the activity of neurones in the lateral hypothalamus and substantia innominata. in the anteroventral part of the inferotemporal cortex, neurones were found with visual responses which were sustained while the animal looked at the appropriate visual stimuli. the latency of the responses was 100 ms ... | 1977 | 406968 |
| a comparison of benzo(a)pyrene metabolism by liver and lung microsomal enzymes from 3-methylcholanthrene-treated rhesus monkeys and rats. | | 1977 | 406987 |
| dose-dependent metabolism of methotrexate in man and rhesus monkeys. | humans and rhesus monkeys receiving high-dose methotrexate (mtx) (greater than 50 mg/kg) excrete significant quantities of the metabolite, 7-hydroxy-mtx. this metabolite, though 200-fold less potent than mtx as an inhibitor of mammalian dihydrofolate reductase, is of very limited aqueous solubility, and thus may contribute to the renal toxicity of the high-dose regimen. the metabolite was not observed in previous pharmacologic studies in which conventional doses of mtx were administered (less th ... | 1977 | 406997 |
| determination of plasma 3-methoxy-4-hydroxyphenyl-glycol by pulsed electron capture gas chromatography. | an improved method is described for determining picogram quantities of 3-methoxy-4-hydroxyphenylglycol (mhpg) in plasma of humans and of other species. the method makes use of gas-liquid chromatography and electron capture detection. low level nonlinearity of detector response was corrected by operating the detector in the pulsed rather then the customary steady state mode. detector overloading was prevented by heat coagulation of plasma proteins and subsequent ultrafiltration. sensitivity was s ... | 1977 | 407037 |
| the conversion of d-norgestrel-3-oxime-17-acetate to d-norgestrel in female rhesus monkeys. | | 1977 | 407050 |
| luteinizing hormone releasing hormone (lhrh) in pituitary stalk blood of rhesus monkeys: relationship to level of lh release. | | 1977 | 407069 |
| studies on the transfer of steroid hormones across the blood-cerebrospinal fluid barrier in the rhesus monkey. ii. | the movement of progesterone (p), cortisol (f) and 17-hydroxyprogesterone (17-ohp) across the blood-cerebrospinal fluid (csf) barrier was determined using six adult male rhesus monkeys with indwelling canulae in the lateral ventricles of their brains. tritiated steroids were given iv as a bolus followed by a constant 6 h infusion with continuous collection of csf and periodic sampling of blood before and during the infusion. the amounts of authentic steroid in the plasma and csf were determined ... | 1977 | 407072 |
| size constancy in rhesus monkeys: effects of pulvinar, prestriate, and inferotemporal lesions. | the present study tested the theory that inferotemporal cortex integrates 1) distance information transmitted via superior colliculus-pulvinar afferents, with 2) form information transmitted via striate-prestriate cortex afferents (gross, 1973a, 1973b). monkeys were trained to choose the larger of two objects, independent of distance, to obtain a reward. based on the integration theory, the following predictions concerning this size constancy discrimination were made: 1) monkeys with pulvinar le ... | 1977 | 407092 |
| the morphology and laminar distribution of cortico-pulvinar neurons in the rhesus monkey. | using autoradiography and the horseradish peroxidase method, the morphology and laminar distribution of cortico-pulvinar neurons and the reciprocity of connections between pulvinar and cortex were examined in five rhesus monkeys which had received medial, lateral and inferior pulvinar nucleus injections of both tritiated amino acids and horseradish peroxidase. cortico-pulvinar neurons were identified in one heterotypical cortical area (area 17) and in many homotypical areas in frontal (areas 45, ... | 1977 | 407094 |
| role of the orbital cortex in cardiac dysfunction in unanesthetized rhesus monkey. | | 1977 | 407098 |
| luteinizing hormone-releasing hormone, ovariectomy, and silastic vaginal rings in the rhesus monkey. | the interaction of estradiol and luteinizing hormone-releasing hormone (lrh) may be a critical physiologic mechanism regulating the occurrence of ovulation in many species. these studies were conducted to assess (1) the effects of intramuscular injections of lrh in the intact female rhesus monkey and (2) the effects of estradiol in a silastic delivery system in ovariectomized female rhesus monkeys. no changes in blood levels of luteinizing hormone (lh) were detected in response to 200 micrograms ... | 1977 | 407108 |
| hypothalamic regulation of insulin release in rhesus monkeys. | evidence of a neurohumoral factor capable of stimulating insulin and glucagon secretion was found in perfusates from ventrolateral hypothalamus (vlh) of rhesus monkeys. the perfusates from the vlh were collected via push-pull cannulas and injected into the peripheral circulation. increase in portal insulin and glucagon was observed following the injection of six different perfusates. the amount of insulin released from isolated rat islets incubated with perfusates was significantly increased at ... | 1977 | 407117 |
| effect of indomethacin on intestinal water transport in salmonella-infected rhesus monkeys. | indomethacin, a nonsteroidal anti-inflammatory agent, will abolish salmonella-induced rabbit ileal secretion when given prior to the establishment of infection. in the present study, we assessed whether indomethacin can inhibit salmonella-induced intestinal secretion when administered after infection and net intestinal secretion are well established. a physiological model of salmonellosis, salmonella-infected rhesus monkeys, was used. this model also permitted an examination of the effects of in ... | 1977 | 407160 |
| effect of a nuclease-resistant derivative of polyriboinosinic-polyribocytidylic acid complex on yellow fever in rhesus monkeys (macaca mulatta). | rhesus monkeys (macaca mulatta) treated with a newly developed nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid, poly-l-lysine, and carboxymethylcellulose [poly (iclc)] did not die after challenge with virulent asibi strain yellow fever (yf) virus. the strain of virus is sensitive to the effects of interferon in vitro and is lethal for rhesus monkeys four to six days after subcutaneous administration of 1,000 plaque-forming units of the virus. the mortality rate was reduced ... | 1977 | 407312 |
| quantitative aspects of proliferation in the nasal epithelium of the rhesus monkey embryo. | proliferation was studied in the nasal epithelium of rhesus monkey embryos ranging in age from 26 through 41 days of gestation (stages 13-20). labeling indices were tabulated 1 h after an intrachorionic injection with [3h]thymidine, and the distribution of labeled cells was determined at intervals ranging from 1h to 11h after injection. the labeling index showed a chronological decrease from 69-4% in the nasal placode at stage 13 to 31-6% in the nasal pit at stage 20. the vomeronasal epithelium ... | 1977 | 407323 |
| effects of behavioral performance on single-unit firing patterns in inferior colliculus of the rhesus monkey. | | 1977 | 407335 |
| distribution of mason-pfizer virus-specific sequences in the dna of primates. | iodinated mason-pfizer virus (mpv) 60-70s rna has been used in molecular hybridization experiments to determine the distribution of mpv-specific proviral sequences in the dnas of primates. approximately 20% of the mpv genome is present as endogenous provirus in rhesus monkeys. competitive hybridization experiments showed no homology between mpv 60-70s rna and the 60-70s rnas of m7, rd-114, and the simian sarcoma virus. no mpv-specific proviral sequences were detected in the dnas of apparently no ... | 1977 | 407372 |
| the effect of vidarabine on the development of the offspring of rats, rabbits, and monkeys. | the effect of vidarabine, a new antiviral agent, on the offspring of rats, rabbits, and monkeys was studied by varying routes of administration during several periods of gestation. vidarabine demonstrated a dose-related teratogenic effect in rats when given parenterally at doses of 30 mg/kg and greater. the drug was also teratogenic in the rabbit at dosages of 5 mg/kg and greater by the parenteral route or when applied topically in 10% concentration to 5 or 10% of the body surface area. the patt ... | 1977 | 407663 |
| a yellow fever epizootic in zika forest, uganda, during 1972: part 1: virus isolation and sentinel monkeys. | the results of the yellow fever immunity survey of central and east africa reported by sawyer & whitman in 1936 prompted scientists to undertake well-planned epidemiological studies on yellow fever in eastern africa. a yellow fever research institute (the present east african virus research institute) was established at entebbe in 1936 for this purpose. one of the areas where much work has been carried out is a strip of typical tropical forest, the zika forest, 12 kilometres from the institute. ... | 1977 | 407675 |
| [radiographic findings in rhesus monkeys experimentally infected with african lung flukes (paragonimus africanus and p. uterobilateralis) (author's transl)]. | the radiographic pattern in the course of experimentally infected rhesus monkeys with the two african fluke species paragonimus africanus and p. uterobilateralis consist of hilar dilatation, streaky, patchy or diffuse shadows, cavities, atelectases and pleural reactions. all animals develop changes in both lungs, those infected with p. africanus preferentially in the lower parts. there is an obvious correlation with the autopsy findings in the same animals as well as radiological features in hum ... | 1977 | 407680 |
| [histopathological alterations in rhesus monkeys after experimental infections with african lung flukes (paragonimus africanus and p. uterobilateralis) (author's transl)]. | histopathological observations in monkeys experimentally infected with african lung flukes are reported. the observations were made on 3 rhesus monkeys, infected with paragonimus africanus from west-cameroon, and on 5 rhesus monkeys, infected with p. uterobilateralis from eastern nigeria. for comparison, the lung of a naturally infected drill (mandrillus leucophaeus) was included in the study. the following lesions were found: formation of parasite cavernae, intense infiltration of the cavern wa ... | 1977 | 407681 |
| vasectomy in rhesus monkeys i. surgical techniques and gross observations. | vasectomy and vaso-occlusion techniques were used in 47 male rhesus monkeys to maximize and minimize the amount of sperm allowed to escape from the vas into surrounding tissues for up to seventy-two weeks postoperatively. body weight changes and blood clinical data indicated that the general health of all the monkeys remained good. normal seasonal changes in body weights and testicular volumes suggested that there were no disturbances to the endocrine system and that the monkeys remained respons ... | 1977 | 407690 |
| vasectomy in rhesus monkeys ii. failure to demonstrate dumoral and cellular immune responses specific for sperm. | | 1977 | 407691 |
| paecilomycosis in a nonhuman primate (macaca mulatta). | focal granulomas caused by fungi in the genus paecilomyces occurred at subcutaneous and laryngeal sites in a rhesus monkey. slight wheezing was noted 8 months before the monkey died. death was unexpected and was caused by asphyxiation after occlusion of the larynx by a fungal granuloma. | 1977 | 407701 |
| fluorescein pattern of the choriocapillaris in the neonatal rhesus monkey. | seven neonatal rhesus monkeys were studied by serial fundus photography and fluorescein angiography at weekly intervals during the first 12 weeks of life. the neonatal rhesus showed little pigmentation of the fundus during the first six weeks of life. the fluorescein angiograms showed a definite sequential as well as segmental filling pattern at the level of the choriocapillaris. this filling pattern was based on individual units called lobules. in addition there was a segmental flow in the macu ... | 1977 | 407797 |
| light microscopic quantitation of the endothelial vacuoles in schlemm's canal. | twelve rhesus monkeys were used for an experiment in which intraocular pressure was maintained at various levels between 0 and 50 mm hg for one hour. a quantitative light microscopic analysis was made of the changes in the vacuolation of the endothelium lining schlemm's canal. at 0 mm hg, giant vacuoles were not found; at 8 mm hg the counts of vacuoles were significantly lower than the corresponding 15 mm hg controls; at 22 and 30 mm hg the counts were significantly higher than the 15 mm hg coun ... | 1977 | 407798 |
| condylar translation and the function of the superficial masseter muscle in the rhesus monkey (m. mulatta). | the relationship between translation of the mandibular condyle during symmetrical mandibular rotation, i.e., symmetrical jaw depression and elevation, and the function of the superficial masseter muscle was examined in light of relative torque and the length-tension relationship for muscle. lateral cephalograms of live adult rhesus monkeys (macaca mulatta) were analyzed using two models: (1) model a, normal symmetrical jaw rotation accompanied by condylar translation; and (2) model b, mandibular ... | 1977 | 407804 |
| differences in the virulence of plasmodium knowlesi for macaca irus (fascicularis) of philippine and malayan origins. | this report summarizes the results of a comparative study of the virulence of the "s-m," h, and c strains of p. knowlesi for indian rhesus monkeys (macaca mulatta) and cynomolgus monkeys [m. irus (fascicularis)] of malayan (west malaysia) and philippine origins. each of the above strains produced fulminating, uniformly fatal infections in the rhesus monkey and mild, chronic infections, characterized by relatively low level parasitemias in cynomolgus monkeys of philippine origin. in striking cont ... | 1977 | 407808 |
| comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers. | this investigation was undertaken to determine whether either d-primaquine or l-primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with plasmodium vivax. it was found: (i) that the capacities of the isomers and the racemate to cure infections with plasmodium cynomolgi in rhesus monkeys were essentially identical; (ii) that the subacute toxicities of the isomers and racemate for this monkey were qualitatively the same, but ... | 1977 | 407841 |
| optic disc edema in raised intracranial pressure. iii. a pathologic study of experimental papilledema. | optic nerve heads of 21 eyes from 13 rhesus monkeys that had developed papilledema secondary to chronically raised intracranial pressure from balloon implantation in the subarachnoid space were studied by light and electron microscopy. nine eyes were also examined with the horseradish peroxidase tracer technique. the pathologic changes in the optic nerve head included severe axonal changes and mild interstitial edema. axonal alteration ranged from axonal swelling to formation of cytoid bodies. i ... | 1977 | 407894 |
| protracted radiation-stressed primate performance. | an experimental investigation has been made of the effects of nuclear radiation on the behavior of four trained primates (rhesus monkeys) proficient in control of the primate equilibrium platform during a hypothetical 72-h aircraft mission. the radiation exposure was assumed to result from a radioactive cloud penetration at the start of the mission, with subsequent low dose rate exposure resulting from radioactive debris in and on the aircraft. minor performance changes were detected in three of ... | 1977 | 407895 |
| histopathology of retinal lesions produced by long-term laser exposure. | the maculae of rhesus monkeys were exposed for 120/s to nd-yag and argon laser radiation at wavelengths of 1060 and 514.5 nm, respectively. histopathology of lesions associated with a thermal and a nonthermal damage mechanism were compared. differences were observed for both lesion development and retinal layers affected, depending upon the damage mechanism involved. | 1977 | 407896 |
| heavy-ion-induced cataractogenesis. | cataract formation following heavy ion exposure (o+8) was noted in three rhesus monkeys secondary to a study of retinal effects. the pathogenesis of these lens changes follows many, but not all, of the characteristics for "radiation cataracts." the ring-shaped opacity was not noted to occur. posterior capsular changes were noted initially and followed through the formation of a mature cataract. | 1977 | 407897 |
| the presence of gonadotropic and thyrotropic cells in the pituitary pars tuberalis of the monkey (macaca mulatta). | immunocytochemistry was utilized to determine if pars tuberalis cells in the pituitary of the monkey (macaca mulatta) have the potential to elaborate gonadotropic and thyrotropic hormones normally secreted by the pars distalis. a total of 7 males and females were studied. the hormones were localized by the peroxidase-antiperoxidase method of sternberger, and utilized with antisera to the following human hormones: somatotropin, mammotropin, beta(1-24)-corticotropin, chorionic gonadotropin, and ... | 1977 | 407948 |
| the concentration maximum concept in intravenous cholangiography. | the excretion of ioglycamate in the bile of the rhesus monkey was measured at 5% and at 100% bile diversion following an intravenous bolus injection of ioglycamate. at 100% diversion the bile volume was reduced and the concentration of ioglycamate was increased, but the quantity excreted was unchanged. a similar study using iodipamide reported previously gave the same result. when the ioglycamate was given by intravenous infusion, the effect of 100% bile diversion was quite different. the concen ... | 1977 | 407962 |
| contributions of the corpus callosum and the anterior commissure to visual activation of inferior temporal neurons. | most neurons in the inferior temporal cortex of the rhesus monkeys have visual receptive fields that extend across the vertical meridian well into both the contralateral and ipsilateral visual half-fields. we examined the role of different portions of the forebrain commissures in providing the ipsilateral input with the following results. (1) combined section of the splenium and anterior commissure eliminated visual activation from the ipsilateral visual half-field. (2) section of the splenium, ... | 1977 | 407973 |
| prefrontal granular cortex of the rhesus monkey. i. intrahemispheric cortical afferents. | | 1977 | 407975 |
| prefrontal granular cortex of the rhesus monkey. ii. interhemispheric cortical afferents. | in 6 adolescent rhesus monkeys, horseradish peroxidase (hrp) was injected into 6 regions of the dorsalateral convexity of the prefrontal granular cortex. the commissural connections originated in both homotopical and heterotopical zones of the hemisphere contralateral to the injection site. the areas affected by the injections, i.e. areas 46,45, 10, 9, 12 and 8a, received extensive homotopical interhemispheric input. hrp-labeled neurons were less extensive in heterotopical as opposed to homotopi ... | 1977 | 407976 |
| inhibition of attachment of neisseria gonorrhoeae to tissue cells by goat milk antigonococcal immunoglobulin g. | an immunoglobulin g (igg)-containing fraction was isolated from milk, obtained from a goat before and after instillation of the mammary gland with neisseria gonorrhoeae colony type 1 (t1). the presence of igg and the absence of immunoglobulins-a and -m in this fraction was confirmed by immunodiffusion in gel and immunoelectrophoresis. postinstillation igg inhibited the attachment of the homologous strain of n. gonorrhoeae (t1) to tissue cells. the percentage of rhesus monkey kidney cells with go ... | 1977 | 407995 |
| [experimental cholera in the monkey]. | experimental studies on cholera in baboons (papio, p. anubis) and rhesus monkeys, have led to unfavourable results. however we have obtained a typical cholera disease in cotton-top marmoset saguines oedipeus. | 1977 | 408045 |
| cortical cells projecting to the dorsal column nuclei of rhesus monkeys. | corticals cells projecting to the dorsal column nuclei (dcn) of rhesus monkeys have been identified after unilateral or bilateral injection of horseradish peroxidase (hrp) into the dorsal medulla. hrp-positive neurons identifiable as the source of cortico-dcn projections were pyramidal cells in layer v whose largest diameters ranged from 12--31 micron. cortico-dcn neurons were concentrated in the trunk, fore- and hindlimb regions of area 4 and of si, and to a lesser extent in sii. this distribut ... | 1977 | 408162 |
| schistosoma japonicum: highly irradiated cercariae as a test for specific immunity in rhesus monkeys. | | 1977 | 408169 |
| peroxidase permeability of the cryogenic chorioretinal adhesion. | under normal conditions the retinal pigment epithelium does not permit passage of peroxidase tracers. photocoagulation disrupts this barrier. rhesus monkeys which received transconjunctival cryotheropy showed a similar disruption, with leakage of horseradish peroxidase into the retina. this leakage persisted for the 6-month duration of the experiment. one month after treatment, a firm chorioretinal adhesion was present, characterized by gliosis, adherent junctions, and cellular interdigitation. ... | 1977 | 408292 |
| fetal rhesus monkey lung development: lobar differences and discordances between stability and distensibility. | | 1977 | 408323 |
| factors influencing sexual performance in male rhesus monkeys. | a 5-yr retrospective study of the sexual behavior of eight adult male rhesus monkeys showed that sexual vigor declined over the years but testosterone levels in peripheral vein plasma did not. two prospective experiments were then carried out on these males during the sixth year. (a) the four poorest performers were injected daily for 28 days with testosterone propionate (1 mg/kg of body weight). there was no significant increase in level of performance, and behavior was not correlated with plas ... | 1977 | 408381 |
| immune neutrality of calf skin collagen gel used to stimulate revitalization in pulpless open apex teeth of rhesus monkeys. | a collagen mineral gel has recently been shown to stimulate revitalization of pulpless open apex teeth when syringed into debrided root canals. experiments were conducted to examine possible stimulation of the immune system by the experimental procedure. ring tests (interface precipitation analysis), ouchterlony plates and hemagglutination tests on plasma samples taken from experimental rhesus monkeys throughout the healing process indicate a complete lack of humoral immune responsiveness to the ... | 1977 | 408383 |
| eruption of the deciduous dentition in the rhesus monkey. | | 1977 | 408386 |
| successful prophylaxis against rabies in mice and rhesus monkeys: the interferon system and vaccine. | addition of interferon to ineffective rabies virus vaccines by the local injection of either exogenous interferon or a potent interferon inducer (a complex of polyriboinosinic-polyribocytidylic acid containing poly-l-lysine and carboxymethylcellulose) into the footpads of mice previously challenged with rabies virus dramatically reduced the mortality rate. a significant reduction in mortality rate was also noted when the interferon system was administered to rhesus monkeys, but only when treatme ... | 1977 | 408427 |
| [the use of primate tissue homogenates for quality control in the creatine kinase-mb determination with inhibiting antibodies (author's transl)]. | the creatine kinase isoenzymes ck-mm, ck-mb and ck-bb from rhesus monkey heart and brain tissue homogenates were separated chromatographically. thereafter it could be demonstrated that the activity of the simian subunit ck-m is completely inhibited by anti-inhibitory-ck-m serum. thus control sera from simian tissue are in principle suited for quality control in an immunological determination of creatine kinase-mb. the intra-assay variance and interassay variance were n = 56, -/x = 29.2 u/1, sd = ... | 1977 | 408459 |
| electrophysiological studies of long-term electrical stimulation of the cerebellum in monkeys. | six rhesus monkeys were stimulated on the paravermal cortex for 205 hours (18 days) with different charge densities in order to determine the electrode performance and neural damage that may result from long-term cerebellar stimulation comparable to that being used in man. the electrode-tissue interface was relatively stable and no neural damage was found when the charge/phase (0.5 muc/ph) or charge density (7.4 muc/sq cm/ph) was very low. at all higher charge levels tested (2.4, 4.8, 10, and 22 ... | 1977 | 408467 |
| tissue reactions to long-term electrical stimulation of the cerebellum in monkeys. | light and electron microscopic analyses were carried out on the stimulated and unstimulated paravermal cortices of six rhesus monkeys that had electrodes implanted on their cerebella for 2 months. the electrodes and the stimulation regime (10 p.p.s.: 8 min on, 8 min off) were similar to those used to stimulate the human cerebellum for treatment of certain neurological disorders. mere presence of the electrode array in the posterior fossa for 2 months resulted in some meningeal thickening, attenu ... | 1977 | 408468 |
| time-dependent kinetics iii: diurnal oscillations in steady-state plasma valproic acid levels in rhesus monkeys. | valproic acid was administered by constant rate intravenous infusion to catheterized chained rhesus monkeys for 8-10 weeks under controlled environmental conditions. steady-state plasma levels were monitored at 2-hr intervals for 26 hr (10 am-12 noon on the following day), 1 day/week for 6 weeks. individual steady-state plasma concentration-time plots exhibited the following characteristics. during period a (10 am-6 pm), plasma levels remained stable or decreased. during period b (6 pm-6 am), pl ... | 1977 | 408478 |
| quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling. | quantification of the suspected metabolites of lidocaine in humans was carried out using the direct insertion probe and chemicalionization mass spectrometry. deuterated analogs of the metabolites of lidocaine were added to serial human plasma and urine samples and were used as internal standards following oral administration of 250 mg of lidocaine hydrochloride monohydrate to two male subjects and 202 mg of lidocaine free base to one male subject. the average results after analysis of the 0-24 h ... | 1977 | 408479 |
| temporal patterns of vasopressin release following electrical stimulation of the amygdala and the neuroendocrine pathway in the monkey. | to evaluate a possible role of the amygdala (amyg) in the neural control of arginine vasopressin (avp) release, adult female monkeys (macaca mulatta) with electrodes chronically implanted in the amyg, hypothalamus and pituitary gland were given 5% dextrose and water infusions and were stimulated electrically at these sites. immediately before and after, and at 5, 10, 15 and 30 min intervals following electrical stimulation, blood samples were withdrawn from unanesthetized monkeys, through implan ... | 1977 | 408726 |
| inferotemporal versus combined pulvinar-prestriate lesions in the rhesus monkey: effects on color, object and pattern discrimination. | | 1977 | 408728 |
| the effects of bilateral frontal eye-field, posterior parietal or superior collicular lesions on brightness thresholds in the rhesus monkey. | | 1977 | 408729 |
| pulp effects of neodymium laser. a preliminary report. | a total of eight teeth from two rhesus monkeys were exposed to various amounts of neodymium laser radiation. the pulp response was found to be much less severe than that in a study of nineteen teeth previously reported for exposure to similar amounts of ruby laser radiation. if additional studies support this initial finding, it is suggested that a re-evaluation of neodymium laser-mediated procedures in vital teeth be initiated. | 1977 | 408778 |
| failure of daily injections of ketamine hcl to adversely alter menstrual cycle length, blood estrogen, and progesterone levels in the rhesus monkey. | failure of daily injections of ketamine hydrogen chloride (hcl) to adversely alter menstrual cycle length, blood estorgen, and progesterone levels in the rhesus monkey is reported. the study was carried out with 30 adult female monkeys to determine the effects of daily administration of 8-10 mg ketamine hcl/kg. in physically restrained control monkeys there were 14 of 25 ovulatory cycles and inketamine-treated monkeys there were 28 of 32 ovulatory cycles. menstrual cycle length was the same i ... | 1977 | 408817 |
| effects of progesterone and estradiol on sexual attractivity of female rhesus monkeys. | | 1977 | 408829 |
| emergence of a kwashiorkor-like syndrome associated with protein-calorie malnutrition in the developing rhesus monkey (macaca mulatta). | | 1977 | 408835 |
| primate information processing under sodium pentobarbital and chlorpromazine: differential drug effects with tachistoscopically presented discriminative stimuli. | sodium pentobarbital and chlorpromazine were evaluated for the degree to which they differentially reduce the speed or efficiency with which sensory information can be processed. rhesus monkeys were tested under comparable doses of sodium pentobarbital and cpz on a visual discrimination problem with varying durations of tachistoscopically presented stimulus information. when unlimited stimulus information was available, no effects of the two drugs were observed at the doses used, but as the dura ... | 1977 | 408852 |
| the effects of electric shock on responding maintained by cocaine injections in a choice procedure in the rhesus monkey. | a choice procedure was used to determine the ability of electric shock to suppress cocaine-maintained responding in a situation where cocaine was also available on a second lever without shock. in each session rhesus monkeys were allowed to self-inject cocaine five times in the presence of a stimulus. thirty minutes after the fifth injection a second dose of cocaine could be self-injected five times in the presence of a different stimulus. at the onset of the injection of this dose a 5 or 10 ma ... | 1977 | 408857 |
| digital k-edge subtraction radiography. | k-edge subtraction images have been produced using a digital video image processor. images formed by three filtered x-ray beams are detected by an image intensifier-plumbicon system, digitilized, and combined in real time to produce bone- and tissue-free k-edge subtraction images of iodinated structures. preliminary studies of rhesus monkey cranial, spinal, and abdominal structures are compared with those of conventional radiography. | 1977 | 408875 |