Publications

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[diagnosis of oroya fever in europe; electron microscopic section investigation of bartonellas]. 195613401723
[present status of research on verruca peruviana]. 195713437124
[present treatment of carrion's disease]. 195713444669
verruga peruana. 195713447815
[carrion's disease; trial experimental infection of white mouse with intranasal inoculation of bartonella bacilliformis]. 195713460670
[carrion's disease; morphological study of bartonella bacilliformis by electron microscope]. 195713460671
[carrion's disease; bartonella bacilliformis resistance to lyophilization]. 195713460686
cellular factors in the acquired immunity to bartonella muris. 195713463384
[daniel alcide carrion, heroic & glorious doctor of peru]. 195713494538
[chloramphenicol therapy of acute bartonellosis (carrion's disease) in the initial phase]. 195713509175
bartonellosis. 195813570654
[the life of daniel a. carrión]. 195813579380
lifespan of rat erythrocytes parasitized by bartonella muris. 195913631283
[case of pulmonary hypoplasia with subsequent tuberculosis]. 195813634539
frozen spleen reimplanted and challenged with bartonella. 196113696589
the hemolytic anemia of human bartonellosis. 196113741078
[physiopathology of the anemia of carrion's disease]. 196013741079
[the influence of bartonella anemia on radiation effect in rats]. 196013747973
[grahamella brumpt 1911. biological and morphological research]. 196013753954
mechanism of splenic protection against 'bartonella muris' in the parabiotic rat. 195913817383
mechanism of splenic protection against 'bartonella muris' in the parabiotic rat. 195913817384
[experimental pulmonary lesions after splenectomy in the white rat. relations with bartonella]. 195913818121
activation of bartonella muris infection in x-irradiated rats. 196213867651
transmissible agents and anemia of mouse cancer. 196313973916
[oroya fever (carrion's disease): an acute acquired hemolytic anemia]. 196314054278
a colony of specific pathogen-free rats. 196414110451
miscellaneous tropical diseases. 196414130793
glutathione instability and changes in protein-bound sugar in rats due to mixed bartonella and trypanosome infection. 196414141856
red cell survival studies. 196414171444
quantitative bone marrow studies in rats following subtotal and total splenectomy. 196414197616
a disease of cattle in south australia resembling st. george disease. ii. laboratory investigation. 196514292823
[the effect of recent antibiotics on haemobartonella muris and eperythrozoon coccoides]. 196414309969
bartonellosis and tetracycline. 195514362456
[acute reticulosis in the course of a bartonella infection]. 195414371810
treatment of the acute febrile phase of carrión's disease with chloramphenicol. 195514376776
[further studies on grahamella brumpt 1911]. 196214459317
infectious angiogenesis: bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor.pathological angiogenesis, the development of a microvasculature by neoplastic processes, is a critical component of the development of tumors. the role of oncogenes in the induction of angiogenesis has been extensively studied in benign and malignant tumors. however, the role of infection in inducing angiogenesis is not well understood. verruga peruana is a clinical syndrome caused by the bacterium bartonella bacilliformis, and is characterized by the development of hemangioma-like lesions, in ...200314507641
cloning and expression of bartonella henselae sucb gene encoding an immunogenic dihydrolipoamide succinyltransferase homologous protein.immunoscreening of a zap genomic library of bartonella henselae strain houston-1 expressed in escherichia coli resulted in the isolation of a clone containing 3.5 kb bamhi genomic dna fragment. this 3.5 kb dna fragment was found to contain a sequence of a gene encoding a protein with significant homology to the dihydrolipoamide succinyltransferase of brucella melitensis (sucb). subsequent cloning and dna sequence analysis revealed that the deduced amino acid sequence from the cloned gene showed ...200314524617
long-term serological analysis and clinical follow-up of patients with cat scratch disease.a highly specific enzyme immunoassay (eia) was recently described for use in the diagnosis of cat scratch disease (csd). however, data regarding eia antibody kinetics or its correlation with long-term clinical follow-up data are lacking. the association between antibody kinetics, clinical spectrum, and disease duration were studied in 98 patients with csd. the median duration of follow-up was 35.3 weeks (range, 2-211.3 weeks). results of eia testing for detection of anti-bartonella henselae immu ...200314557957
conjunctival cat-scratch disease simulating rhabdomyosarcoma. 200314560840
vector-borne illnesses and the safety of the blood supply.the protection of patients from diseases carried in blood transfusions is an ongoing effort. the viruses that cause long-term human infection and death have received much of the attention in the united states and testing has significantly diminished the risk of infection from a transfusion. as the risk of these diseases has decreased, other transfusion-transmitted organisms with a lower incidence in the community or newer diseases with rapidly expanding endemic areas are receiving additional att ...200314561396
characterization of the natural population of bartonella henselae by multilocus sequence typing.investigations of the population genetics of bartonella henselae have demonstrated a high level of diversity among strains, and the delineation of isolates into one of two subtypes, type i (houston) and type ii (marseille), represented by specific 16s ribosomal dna (rdna) sequences, has long been considered the most significant genotypic division within the species. this belief is challenged by recent work suggesting a role for horizontal gene exchange in generating intraspecies diversity. we at ...200314605141
pericardial effusion in a homeless man due to bartonella quintana.bartonella quintana may cause trench fever, endocarditis, bacillary angiomatosis, and chronic bacteremia, and a reemergence among homeless populations in cities has been noted. pericarditis from rickettsia conorii and coxiella burnetii infection has been described, but there have been no reports of pericarditis due to bartonella spp. we report a case of pericardial effusion due to bartonella quintana in a homeless man, diagnosed on the basis of pcr detection of bartonella quintana in a pericardi ...200314605187
isolation of bartonella washoensis from a dog with mitral valve endocarditis.we report the first documented case of bartonella washoensis bacteremia in a dog with mitral valve endocarditis. b. washoensis was isolated in 1995 from a human patient with cardiac disease. the main reservoir species appears to be ground squirrels (spermophilus beecheyi) in the western united states. based on echocardiographic findings, a diagnosis of infective vegetative valvular mitral endocarditis was made in a spayed 12-year-old female doberman pinscher. a year prior to presentation, the re ...200314605197
fatal case of endocarditis associated with bartonella henselae type i infection in a domestic cat.we report the first feline case of bartonella henselae endocarditis. despite negative blood cultures, the cat had high bartonella antibody titers and b. henselae type i dna was detected in the damaged aortic valve. microscopic examination of the valve revealed endocarditis with small silver positive coccoid structures in endothelial cells.200314605199
bartonella and coxiella antibodies in 334 prospectively studied episodes of infective endocarditis in sweden.bartonella spp. have been identified as aetiological agents in culture-negative infective endocarditis (ie). coxiella burnetii may cause chronic q-fever with endocarditis, 334 blood samples collected from 329 patients (334 episodes) with ie diagnosed between 1984 and 1996 in göteborg, sweden, were investigated for antibodies to bartonella spp. and c. burnetii. 71 of the episodes (21%) were blood culture negative. a microimmunofluorescence assay revealed immunoglobulin g (igg) antibodies to barto ...200314606611
simplified serological diagnosis of endocarditis due to coxiella burnetii and bartonella.we tested a single-step serological assay against coxiella burnetii and bartonella species and found a sensitivity of 100%, and a positive predictive value of 98% for the diagnosis of blood culture-negative endocarditis (bcne). this assay should be considered as a possible commercial test for the diagnosis of bcne.200314607881
cat or dog ownership and seroprevalence of ehrlichiosis, q fever, and cat-scratch disease. 200314609477
bacterial diversity in worker adults of apis mellifera capensis and apis mellifera scutellata (insecta: hymenoptera) assessed using 16s rrna sequences.high-fidelity pcr of 16s rrna sequences was used to identify bacteria associated with worker adults of the honeybee subspecies apis mellifera capensis and apis mellifera scutellata. an expected approximately 1.5-kb dna band, representing almost the entire length of the 16s rrna gene, was amplified from both subspecies and cloned. ten unique sequences were obtained: one sequence each clustered with bifidobacterium (gram-positive eubacteria), lactobacillus (gram-positive eubacteria), and gluconace ...200314615218
an unusual case of cat-scratch disease from bartonella quintana mimicking inflammatory breast cancer in a 50-year-old woman.cat-scratch disease of the breast has been previously reported. this report describes a very unusual case of cat-scratch disease of the breast caused by bartonella quintana in which the clinical and radiographic presentation mimicked that of inflammatory breast cancer.200314616946
concurrent bartonellosis and babesiosis in a dog with persistent thrombocytopenia.a 12-year-old castrated male west highland white terrier was referred because of recurrent episodes of collapsing. the dog was mildly anemic and severely thrombocytopenic and had high serum alanine aminotransferase activity. infection with bartonella vinsonii (berkhoffii) was initially diagnosed on the basis of serologic testing. despite treatment with a series of antimicrobials and prolonged use of immunosuppressive drugs, thrombocytopenia persisted. after 5 months of treatment, babesia canis o ...200314621218
mitogenic effect of bartonella bacilliformis on human vascular endothelial cells and involvement of groel.bartonellae are bacterial pathogens for a wide variety of mammals. in humans, bartonellosis can result in angioproliferative lesions that are potentially life threatening to the patient, including bacillary angiomatosis, bacillary peliosis, and verruga peruana. the results of this study show that bartonella bacilliformis, the agent of oroya fever and verruga peruana, produces a proteinaceous mitogen for human vascular endothelial cells (huvecs) that acts in a dose-dependent fashion in vitro with ...200314638782
neuroretinitis associated with cat-scratch disease in japanese patients.to clarify the prevalence and clinical profile of neuroretinitis associated with cat-scratch disease (csd) in japan.200314641271
bartonella vinsonii subspecies berkhoffi as a possible cause of anterior uveitis and choroiditis in a dog.a 2-year old, neutered, female spaniel mixed breed was referred to the north carolina state university veterinary teaching hospital for evaluation of bilateral anterior uveitis. the dog was febrile and, in addition to anterior uveitis, multifocal hyporeflective lesions were present in the tapetal fundus of both eyes. the antibody titer for bartonella vinsonii subspecies berkhoffi was positive (1 : 512). aqueous paracentesis was performed for pcr in an attempt to detect b. vinsonii in the eye but ...200314641826
from trench fever to endocarditis.the case of a 44 year old woman with infective endocarditis due to bartonella quintana, an organism long recognised to cause a condition known as trench fever, is reported. this case illustrates the lengthy differential diagnosis of "culture negative" endocarditis. in addition the presence of serological cross reactivity of bartonella spp and chlamydia spp demonstrates the potential for misdiagnosis in these circumstances.200314654579
carrión's disease: an altitude-associated infectious disease. 200314656265
identification and characterization of the ddlb, ftsq and ftsa genes upstream of ftsz in bartonella bacilliformis and bartonella henselae.homologues of the cell division protein ftsz were previously identified in bartonella bacilliformis and bartonella henselae. we report herein that ftsz is located at the distal end of an operon that includes ddlb, ftsq, and ftsa. these genes code for homologues of d-alanine d-alanine ligase, an enzyme involved in cell wall biosynthesis, and ftsq, and ftsa, which are involved in cell division. the ddlb, ftsq, and ftsa proteins from bartonella species are most homologous to proteins in closely rel ...200314659047
the x-linked hyper-igm syndrome: clinical and immunologic features of 79 patients.the x-linked hyper-igm (xhigm) syndrome is an uncommon primary immunodeficiency disease caused by mutations in the gene for cd40 ligand and characterized by normal or elevated serum igm, reduced levels of igg and iga, and defective t-cell function. because of its rarity, it has been difficult for any single investigator or institution to develop a comprehensive clinical picture of this disorder. accordingly, a national registry was developed in the united states to provide demographic, genetic, ...200314663287
etiologic diagnosis of 204 pericardial effusions.the etiologic evaluation of pericardial effusion is frequently unsuccessful when noninvasive methods are used. to determine the cause of the current episode, all patients with echographically identified pericardial effusion from may 1998 to december 2002 underwent noninvasive diagnostic testing of blood, throat, and stool samples. patients with postpericardiotomy syndrome were excluded. to analyze the value of our tests, we tested randomly selected blood donors as negative controls. among 204 in ...200314663288
high prevalence of antibodies to bartonella henselae among italian children without evidence of cat scratch disease.few data are available on the seroprevalence of antibodies to bartonella henselae among children. we retrospectively evaluated the presence of immunoglobulin g and m class antibodies to b. henselae in 508 children living in central italy who were apparently free of any features suggesting b. henselae infection. we found that b. henselae infection is common among children in central italy, occurs early in life, is in most cases asymptomatic, and resolves spontaneously.200414679462
causes of febrile illnesses after a tick bite in slovenian children.to establish the etiology in slovenian children with febrile illnesses occurring after a tick bite.200314688569
pathologic quiz case: a 17-year-old renal transplant patient with persistent fever, pancytopenia, and axillary lymphadenopathy. bacillary angiomatosis of the lymph node in the renal transplant recipient. 200414692837
bartonella henselae infection associated with neuroretinitis, central retinal artery and vein occlusion, neovascular glaucoma, and severe vision loss.to report a case of bartonella henselae infection.200414700670
images in clinical medicine. optic neuritis due to bartonella henselae infection. 200414711929
factors affecting the component community structure of haemoparasites in common voles ( microtus arvalis) from the mazury lake district region of poland.the prevalence and abundance of infections with haemoparasites were studied over a 4-year period in microtus arvalis (common vole, n =321) sampled from fallow grassland sites in north-eastern poland. total species richness was five (prevalence= haemobartonella sp. 63.9%, bartonella spp. 27.7%, babesia microti 9.0%, trypanosoma sp. 8.4% and and hepatozoon lavieri 3.1%) with 76.9% of the voles carrying at least one species and a mean infracommunity species richness of 1.1. variation in species ric ...200414714180
prevalence of bartonella henselae in italian stray cats: evaluation of serology to assess the risk of transmission of bartonella to humans.bartonella henselae is the major etiological agent of cat scratch disease in humans. cats act as the natural reservoir of b. henselae and can transmit the infection to humans by a bite or scratch. the prevalence of b. henselae in cat populations was evaluated by serological and bacteriological tests. a total of 769 stray cats from three urban and three rural areas in northern italy were sampled between january 1999 and december 2000. the positive and the negative predictive values of serological ...200414715763
comparative molecular and microbiologic diagnosis of bacterial endocarditis.sequencing of 16s rdna, and of sodaint and rpobint in some cases, was applied to dna from heart valves of 46 patients (36 with definite and 10 with possible endocarditis). sequence-based identifications were compared with those obtained with conventional methods. among the 36 definite cases, 30 had positive blood cultures and 6 had negative cultures. among the 30 positive cases, sequencing of 16s rdna permitted identification of species (18), genus (8), or neither (4); sodaint and rpobint sequen ...200314720393
infective endocarditis.despite improvements in health care, the incidence of infective endocarditis has not decreased over the past decades. this apparent paradox is explained by a progressive evolution in risk factors; while classic predisposing conditions such as rheumatic heart disease have been all but eradicated, new risk factors for infective endocarditis have emerged. these include intravenous drug use, sclerotic valve disease in elderly patients, use of prosthetic valves, and nosocomial disease. newly identifi ...200414726169
bartonella: a new etiological agent of feline ocular disease. 200414736899
identification of bartonella strains isolated from wild and domestic ruminants by a single-step pcr analysis of the 16s-23s intergenic spacer region.of the 20 species or subspecies of bartonella currently known, 7 cause various diseases in humans with many being zoonotic. however, some bartonella species appear only to cause asymptomatic bacteraemia in their hosts. in ruminants, three bartonella species (b. bovis, b. capreoli and b. schoenbuchensis) have recently been described. however, limited or no information has yet been published concerning their mode of transmission and their possible pathogenicity for domestic cattle. the phylogeneti ...200414738783
bartonella chomelii sp. nov., isolated from french domestic cattle (bos taurus).two strains of bacteria isolated from the blood of french domestic cows were found to be similar to bartonella species on the basis of phenotypic characteristics. genotypic analysis based on sequence comparison of the 16s rrna and citrate synthase (glta) genes and on dna-dna hybridization showed that the two isolates represent a distinct and new species of bartonella. moreover, the phylogenetic analysis inferred from comparison of 16s rrna and glta sequences demonstrated that the new bartonella ...200414742483
hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature.hemophagocytic syndrome (hps) combines febrile hepatosplenomegaly, pancytopenia, hypofibrinemia, and liver dysfunction. it is defined by bone marrow and organ infiltration by activated, nonmalignant macrophages phagocytizing blood cells. hps is often caused by an infectious or neoplastic disease and has rarely been described in renal transplant recipients.200414742988
necrotizing glomerulonephritis caused by bartonella henselae endocarditis.glomerulonephritis secondary to endocarditis is uncommon and usually associated with valvular infection by blood culture-positive bacteria. we report 3 cases of necrotizing glomerulonephritis associated with culture-negative endocarditis caused by bartonella henselae. two of the patients presented with renal abnormalities and were investigated for endocarditis after results of renal biopsy. all 3 patients had an immune complex-mediated necrotizing and crescentic glomerulonephritis with mesangial ...200414750122
role of bartonella henselae endocarditis in the nucleation of aortic valvular calcification.a 6-year-old boy presented with fatigability, shortness of breath, and bulging neck veins. echocardiography revealed large vegetations, aortic insufficiency, a dilated left ventricle, and bicuspid aortic valve. there was no history of immunocompromise, fevers, or feline exposures. blood cultures were negative; antibodies against bartonella henselae were positive. gentamicin was administered intravenously. ross procedure was performed and patient was discharged on antibiotics in 5 days. native va ...200414759468
antinuclear antibodies can be detected in dog sera reactive to bartonella vinsonii subsp. berkhoffii, ehrlichia canis, or leishmania infantum antigens.the presence of antinuclear antibodies (anas) is used to support a clinical diagnosis of systemic lupus erythematosus (sle) in dogs. however, clinicians must interpret the detection of anas with caution, particularly in light of increasing evidence that dogs with known bacterial and protozoal infections can have high ana titers. retrospectively, medical records were reviewed for all dogs that were concurrently tested for antinuclear antigens and bartonella vinsonii (berkhoffii), ehrlichia canis, ...200414765731
a prospective study of canine infective endocarditis in northern california (1999-2001): emergence of bartonella as a prevalent etiologic agent.a prospective study was performed (june 1999 to may 2001) to determine the incidence of infective endocarditis (ie) due to bartonella in dogs in northern california and to compare these patients with other dogs with ie. ie was diagnosed antemortem based on clinical signs and echocardiography in 18 dogs. the etiologic agent was bartonella sp. in 5 dogs (28%) and was diagnosed by high seroreactivity to bartonella (titer > 1:512; range, 1:1,024-1:4,096); and confirmed postmortem by positive polymer ...200414765733
growth characteristics of bartonella henselae in a novel liquid medium: primary isolation, growth-phase-dependent phage induction, and metabolic studies.bartonella henselae is a zoonotic pathogen that usually causes a self-limiting infection in immunocompetent individuals but often causes potentially life-threatening infections, such as bacillary angiomatosis, in immunocompromised patients. both diagnosis of infection and research into the molecular mechanisms of pathogenesis have been hindered by the absence of a suitable liquid growth medium. it has been difficult to isolate b. henselae directly from the blood of infected humans or animals or ...200414766538
prevalence, risk factors, and genetic diversity of bartonella henselae infections in pet cats in four regions of the united states.blood was collected from a convenience sample of 271 pet cats aged 3 months to 2 years (mean age, 8 months, median and mode, 6 months) between may 1997 and september 1998 in four areas of the united states (southern california, florida, metropolitan chicago, and metropolitan washington, d.c.). sixty-five (24%) cats had bartonella henselae bacteremia, and 138 (51%) cats were seropositive for b. henselae. regional prevalences for bacteremia and seropositivity were highest in florida (33% and 67%, ...200414766832
structure and biological activity of the short-chain lipopolysaccharide from bartonella henselae atcc 49882t.the facultative intracellular pathogen bartonella henselae is responsible for a broad range of clinical manifestations, including the formation of vascular tumors as a result of increased proliferation and survival of colonized endothelial cells. this remarkable interaction with endotoxin-sensitive endothelial cells and the apparent lack of septic shock are considered to be due to a reduced endotoxic activity of the b. henselae lipopolysaccharide. here, we show that b. henselae atcc 49882(t) pro ...200414766898
chemoprophylactic effectiveness of aureomycin and terramycin in murine bartonellosis. 195014781155
complement fixation and weil-felix reaction in rabbits inoculated with bartonella bacilliformis. 195014794897
the influence of penicillin and streptomycin on experimental bartonellosis of rats. 195014821754
chemotherapeutic effectiveness of alloxan in murine bartonellosis. 195114844245
the effect of x-irradiation on rats with and without bartonella muris. 195114850746
absence of bartonella infection in rats with intestinal culs-de sac and macrocytic anaemia. 195114874170
[adrenalectomy causing activation of latent blood infections (hematozoa and bartonella) in the white rat]. 195114905724
observations on a bartonella organism in cattle. 195214922264
[premunitive vaccination against bovine anaplasmosis]. 195214944295
[typical knee pain in girls]. 195214951632
[new investigations on bartonella bacilliformis. i. morphology of cultured variety]. 195214951682
[an endoglobular parasite in the dendrohyrax]. 195214953083
[new investigations on bartonella muris mayer. ii..]. 195214959268
[new investigations on bartonella bacilliformis. ii. effects of sulfonamides & antibiotics in vitro]. 195214959269
mr signal changes in a child with cat scratch disease encephalopathy and status epilepticus. 200414963382
the influence of climate on the epidemiology of bartonellosis in ancash, peru.the aim of this study was to evaluate the association between bartonellosis and selected climatic factors during the time periods 1983-1988 and 1995-99, which included two events of the el niño phenomenon (1986-88, 1997-98), and to identify a reliable climate parameter to be used as an alert indicator for bartonellosis outbreaks in ancash. the study site was ancash and its province carhuaz, peru. time-series cross-correlation analysis was used to assess the association between bartonellosis and ...200414964812
first isolation of bartonella henselae type i from a cat-scratch disease patient in japan and its molecular analysis.we isolated bartonella henselae from an inguinal lymph node of a 36-year-old male patient with cat-scratch disease. the patient had many areas of erythema on his body, swelling of the left inguinal lymph nodes with pain and slight fever. the diagnosis was made on the basis of polymerase chain reaction for b. henselae dna from the lymph node biopsies and blood sample, and isolation of the organism, histology of the lymph node and serology with an indirect immunofluorescent antibody test. we also ...200414978335
[carrión-disease--history of a long-forgotten malady]. 200414978887
clinicopathological abnormalities and treatment response in 24 dogs seroreactive to bartonella vinsonii (berkhoffii) antigens.bartonella vinsonii (b. vinsonii) subspecies berkhoffii is a recently recognized cause of endocarditis, myocarditis, and granulomatous disease in dogs. in an effort to elucidate other potential disease manifestations, the case records of 24 dogs that were seroreactive to b. vinsonii (berkhoffii) antigens were studied retrospectively. diagnoses included immune-mediated hemolytic anemia, neutrophilic or granulomatous meningoencephalitis, neutrophilic polyarthritis, cutaneous vasculitis, and uveiti ...200415007043
[cutaneous infections in the homeless]. 200315008208
natural breeding places of phlebotomine sandflies.methods of finding larvae and pupae of phlebotomine sandflies (diptera: psychodidae) are described and the known types of breeding sites used by sandflies are listed. three ways of detecting sandfly breeding places are the use of emergence traps placed over potential sources to catch newly emerged adult sandflies; flotation of larvae and pupae from soil, etc., and desiccation of media to drive out the larvae. even so, remarkably little information is available on the ecology of the developmental ...200415009450
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