| [european aspects of lyme disease. 8 cases]. | a case of meningo-radiculitis consecutive to tick bite with isolation, for the first time in france, of a borrelia burgdorferi strain prompted us to review the records of patients admitted to our hospital department with lyme disease. meningo-radiculitis was the predominant feature of the clinical syndrome. it seems to be one of the usual forms of lyme disease in europe. | 1987 | 2949308 |
| [neurologic aspects of lyme disease]. | the neurological manifestations of lyme disease--a condition caused by a spirochete (borrelia burgdorferi) and transmitted by a tick ixodes dammini)--consist of chronic lymphocytic meningitis, cranial neuritis and radiculoneuritis associated to varying degrees. the tick-borne meningoradiculitis well known in europe (garin-bujadoux-bannwarth syndrome) appears, with very slight differences, as equivalent to the neurological manifestations of lyme disease. lesions of the central nervous system, whi ... | 1987 | 2949311 |
| [lyme disease: diagnostic value of quantitative determination of antibodies in the cerebrospinal fluid]. | | 1987 | 2950472 |
| cellular immune response in lyme disease: the response to mitogens, live borrelia burgdorferi, nk cell function and lymphocyte subsets. | although some manifestations of lyme disease may be secondary to the presence of b. burgdorferi, the immune system appears to play a significant role in the clinical manifestations of the disease. the humoral response is well characterized, however the cellular response remains poorly defined. to further define cellular immunity in lyme disease, the responses of lymphocytes from patients with active lyme disease were assessed to con a, pha, pwm, tetanus toxoid, and whole live b. burgdorferi. in ... | 1986 | 2953150 |
| giant cell arteritis and borrelia infection. | | 1987 | 2958514 |
| [borrelian meningoencephalomyelitis. a case]. | a 22-year old man had spastic paraparesis and cerebellar syndrome of 5 months duration. csf showed lymphocytosis, elevated protein content, hypoglycorachia, hypochlorurachia and oligoclonal banding. ct scan and mri were normal. extensive laboratory procedures disclosed no bacterial, viral, fungic, parasitic or inflammatory disease. anti-borrelia burgdorferi antibodies were present in blood (1/4000) and in csf (1/1024). with antibiotics (penicillin g 20 millions units per day for 10 days, followe ... | 1987 | 2962086 |
| [multiple plaque scleroderma with seroconversion for borrelia burgdorferi]. | | 1987 | 2962112 |
| [lyme disease--a new infection from natural foci]. | | 1988 | 2965619 |
| [current status of foci of tick-borne relapsing fever in kashka-darya province]. | | 1987 | 2966279 |
| [identification and initial results of the study of lyme disease in northwestern ussr]. | | 1988 | 2966893 |
| [serologic examination of convalescents and members of their families in tick-borne central asian borreliosis]. | | 1988 | 2973554 |
| [current epidemiology of central asiatic tick-borne borreliasis (based on the example of the fergana region)]. | | 1988 | 2976473 |
| [comparative evaluation of 2 methods for demonstrating borrelia in ticks--the vectors of lyme disease]. | | 1988 | 2978047 |
| absence of spirochaetes (borrelia burgdorferi) and piroplasms (babesia microti) in deer ticks (ixodes dammini) parasitized by chalcid wasps (hunterellus hookeri). | an entomophagous wasp (hunterellus hookeri howard) parasitizes about a third of the host-seeking nymphal ixodes dammini spielman et al. ticks on naushon island in massachusetts (u.s.a.) where the agents of lyme disease (borrelia burgdorferi johnson et al.) and human babesiosis (babesia microti franca) are enzootic. following blood-feeding, wasp-parasitized ticks are destroyed by the developing wasp. the prevalence of either human pathogen in host-seeking ticks collected in wasp-infested sites is ... | 1987 | 2979518 |
| [meningoradiculitis caused by a spirochete (borrelia burgdorferi) after arthropod bite]. | eight cases of meningoradiculitis (garin-bujadoux-bannwarth's syndrome) are presented; the first case followed an "unidentified insect" bite and erythema chronicum migrans, whereas the second and third cases were not preceded by any documented insect bite or erythema; they occurred during summer in 1984 and 1985 and were characterized by cranial or radicular neuritis, lymphocytic meningitis, positive serology by immunofluorescence against borrelia burgdorferi and a good response to penicillin (2 ... | 1985 | 3008294 |
| neuropathy of vasculitic origin in a case of garin-boujadoux-bannwarth syndrome with positive borrelia antibody response. | a 42-year-old man suffered from erythema chronicum migrans on different parts of the body after repeated tick bites. a few months after the last tick bite he developed a painful neuropathy in both legs with patchy disturbance of sensibility, mild weakness of the feet and loss of the right ankle jerk. repeated determinations of antibodies against borrelia spirochetes revealed increasing igg titres. biopsy of the left sural nerve, which was clinically and electrophysiologically affected, showed a ... | 1986 | 3009723 |
| [double infection with early summer meningoencephalitis virus and borrelia burgdorferi]. | a 68-year-old woman developed a meningoencephalitis 18 days after a tick bite. igg and igm antibodies against tick-encephalitis virus were demonstrated, by enzyme-linked immunoabsorbent assay, in both serum and cerebrospinal fluid (csf). lymphoplasmocytic pleocytosis was present in csf for over six weeks, as was an increased igm level. three weeks after the onset of neurological symptoms and clearing of the encephalitis there occurred multiple peripheral pareses in the left leg which were slow t ... | 1986 | 3011378 |
| organization of genes encoding two outer membrane proteins of the lyme disease agent borrelia burgdorferi within a single transcriptional unit. | ospa and ospb are major outer membrane proteins and antigens of the lyme disease spirochete, borrelia burgdorferi. we examined the organization of ospa and ospb, the genes encoding these proteins. the location and direction of transcription of each osp gene was determined by subcloning, deletion analysis, and transposon tn5 mutagenesis. transposon tn5 insertions within the ospa gene abrogated expression of ospb, suggesting that these genes are transcribed from a common promoter. northern blot an ... | 1986 | 3019889 |
| lymphomatous meningitis appearing as garin-bujadoux-bannwarth meningopolyneuritis. | | 1987 | 3029334 |
| infectious bursal disease and spirochetosis in pullet chicks. | infectious bursal disease and spirochetosis were diagnosed simultaneously in a flock of 100 six-week-old babcock pullet chicks. larvae of the fowl tick argas persicus were found on the bodies of the chicks. thirty-nine of the chicks died 5 days after the onset of clinical signs. | 1987 | 3034231 |
| unusual manifestations of nervous system borrelia burgdorferi infection. | borrelia burgdorferi infection may show disease manifestations in different organ systems, including the skin, heart, central nervous system, peripheral nervous system, and joints. we report two hitherto unknown (to our knowledge) disease manifestations, an arteritis in the central nervous system, and a neuromyopathy of 11 years' duration. diagnoses were made by demonstrating specific antibodies against b burgdorferi in the cerebrospinal fluid, and elevated specific antibody index. both patients ... | 1987 | 3036051 |
| [neurologic diseases transmitted by ticks]. | apart from causing various dermatological disorders, ticks, which also widespread in our part of the world, can transmit diseases that affect the nervous system. the difficulty of carrying out differential diagnosis and the possibility of administering causal treatment in cases of meningopolyneuritis garin-bujadoux-bannwarth and progressive borrelian encephalomyelitis are giving rise to demands for an improvement in immunodiagnosis. | 1987 | 3037808 |
| clinical and serologic evaluations of induced borrelia burgdorferi infection in dogs. | adult beagles were used to evaluate clinical signs and serologic response after inoculation with, or exposure to, borrelia burgdorferi. an indirect immunofluorescent assay (ifa) and 2 elisa were used to monitor the serologic response to b burgdorferi. feeding infected ticks on 4 dogs (group 1) failed to cause seroconversion, and sc inoculation with 500 organisms caused minimal seroconversion in 2 of 4 dogs (group 2). at 56 days, approximately 3.01 x 10(8) b burgdorferi organisms were injected iv ... | 1988 | 3041881 |
| [serodiagnosis of lyme borreliosis]. | there are various serodiagnostic tests available for the detection of antibodies against borrelia burgdorferi. an indirect hemagglutination assay, which can detect both igm and igg antibodies, was developed for antibody screening. regarding the confirmation and differentiation of igm and igg, we use the indirect immunofluorescence assay (most specific when performed with sera previously absorbed with treponema phagedenis) as well as the elisa test. the detection of significantly elevated antibod ... | 1988 | 3043955 |
| [ecology of tick-borne infections in fennoscandia--a review]. | | 1988 | 3045463 |
| [suspected syphilis during pregnancy due to cross reactions in borrelia infection]. | a weakly positive titre (1:20) in the treponema pallidum haemagglutination test and a highly positive titre (1:1280) in the fluorescence treponema antibody absorption test, but negative result for igm antibodies, were found in the serum of a 23-year-old pregnant woman. the cardiolipin microflocculation test was at first borderline positive, but negative on repeat. in the absence of a history of syphilis tests for borrelia antibodies were performed. those for antibodies against b. burgdorferi wer ... | 1988 | 3048959 |
| serodiagnosis of early lyme disease: analysis of igm and igg antibody responses by using an antibody-capture enzyme immunoassay. | we used an antibody-capture enzyme immunoassay (eia) to evaluate the early antibody responses to borrelia burgdorferi in paired sera from 30 patients with erythema chronicum migrans. during acute disease, 20 (67%) patients had elevated specific igm responses, and by convalescence (one to four weeks after treatment), 28 (93%) patients had increased igm or igg responses. in acute specimens, elevated igm responses correlated with disseminated infection; however, by convalescence, most patients with ... | 1988 | 3049839 |
| seronegative lyme disease. dissociation of specific t- and b-lymphocyte responses to borrelia burgdorferi. | the diagnosis of lyme disease often depends on the measurement of serum antibodies to borrelia burgdorferi, the spirochete that causes this disorder. although prompt treatment with antibiotics may abrogate the antibody response to the infection, symptoms persist in some patients. we studied 17 patients who had presented with acute lyme disease and received prompt treatment with oral antibiotics, but in whom chronic lyme disease subsequently developed. although these patients had clinically activ ... | 1988 | 3054554 |
| antigenic variation of surface proteins of borrelia species. | during relapsing fever, the etiologic spirochetes employ antigenic variation to avoid early immune clearance. in borrelia hermsii, an agent of tick-borne relapsing fever, a switch in serotype is associated with a change in the predominant protein on the surface of the cells. the variable major proteins differ from one another in primary structure along their lengths. genes encoding the different variable major proteins can be found in both "silent" and "active" environments. at the active site t ... | 1988 | 3055207 |
| [lyme disease. clinical, biological and developmental aspects. 29 cases in the orléans region]. | the description of lyme's disease (ld) in 3 stages (like syphilis), has now become classical. 29 cases of ld, between june 1981 and november 1986, have been recorded at the hospital in orleans. the first twelve patients that were clinically diagnosed before the serology was introduced in france, have been recalled in order to search for possible late forms and assay their antibody level of anti-borrelia burgdorferi. the preponderance of neurological forms (22 cases) and the scarcity of periphera ... | 1988 | 3055243 |
| modulation of natural killer cell activity by borrelia burgdorferi. | | 1988 | 3056196 |
| serologic diagnosis of lyme disease. | indirect fluorescent antibody tests and enzyme-linked immunosorbent assays are being used as laboratory aids for the diagnosis of lyme disease and related disorders. depending on the needs, polyvalent or class-specific reagents can be used to detect total immunoglobulins (ig) or igm and igg antibodies. the sensitivities of these assays are relatively low when serum samples are obtained from patients within 3 weeks after onset of erythema migrans and are tested by either the ifa method or elisa. ... | 1988 | 3056197 |
| mammalian and avian reservoirs for borrelia burgdorferi. | | 1988 | 3056198 |
| antibiotic therapy of early european lyme borreliosis and acrodermatitis chronica atrophicans. | in a study on 121 consecutive patients with erythema migrans, 65 patients obtained oral penicillin, 36 tetracyclines, and 20 amoxicillin-clavulanic-acid. follow-up was carried out for a median of 29, 17, and 7 months, respectively. in another limited trial on 29 patients with acrodermatitis chronica atrophicans (aca), 14 patients received oral penicillin, 9 parenteral penicillin, and 6 tetracyclines. there was no statistically significant difference among treatment groups in both therapeutic tri ... | 1988 | 3056202 |
| new chemotherapeutic approaches in the treatment of lyme borreliosis. | 1. it was demonstrated that while b. burgdorferi may be sensitive to relatively small concentrations of penicillin and ceftriaxone, the organism is killed slowly. this implies that, as in syphilis, prolonged blood levels of these drugs may be necessary in order to ensure cure. in contrast, the activity of tetracycline is more rapid in its action but is more dependent on drug concentration achieved. unfortunately, the mic and mbc for some strains are at or above the peak level achieved under opti ... | 1988 | 3056203 |
| early and late cutaneous manifestations in ixodes-borne borreliosis (erythema migrans borreliosis, lyme borreliosis). | | 1988 | 3056204 |
| synovial fluid eosinophilia in lyme disease. | we describe three 14-year-old boys who developed synovial fluid eosinophilia associated with lyme disease. one patient, with arthritis that began in 1975, had the first documented case of lyme disease in new jersey. lyme disease should be considered when eosinophilia is noted on analysis of synovial fluid from patients with undiagnosed arthritis. | 1988 | 3056421 |
| [possibilities for preserving material for the serologic diagnosis of tick-borne borreliosis]. | | 1988 | 3057339 |
| clinical and neuroimmunological findings in chronic borrelia burgdorferi radiculomyelitis (lyme disease). | | 1988 | 3058745 |
| [acute and chronic borreliosis transmitted by ticks in europe]. | ticks are direct pathogenic agents, and also transmit some infectious diseases such as borreliosis. clinical manifestations of borreliosis are multiple. they most often affect the skin, nervous system, joints and heart. cutaneous pseudolymphomas, erythema chronicum migrans of afzelius, acrodermatitis chronica atrophicans of pick-herxheimer, meningo-radiculitis and various arthropathies are the most commonly encountered diseases. | 1988 | 3059096 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 51-1988. a 92-year-old woman with several cranial-nerve defects and weakness of the left leg. | | 1988 | 3059193 |
| atrophoderma (pasini-pierini). findings on direct immunofluorescent, monoclonal antibody, and ultrastructural studies. | a patient with atrophoderma (pasini-pierini) was studied. microscopic examination showed small collections of mononuclear cells around dermal blood vessels. electron microscopic study demonstrated macrophages and lymphocytes around vessels and between fibers in the dermis; the epidermis, dermis, collagen, and elastic fibers appeared normal. monoclonal antibody studies of the cells in the perivascular infiltrate demonstrated cells reacting with anti-leu-1 (pan-t-cell antibody), anti-leu-3a (the h ... | 1988 | 3065258 |
| laboratory aspects of lyme borreliosis. | lyme borreliosis (lyme disease), a common tick-borne disorder of people and domestic animals in north america and europe, is caused by the spirochete borrelia burgdorferi. following the discovery and initial propagation of this agent in 1981 came revelations that other tick-associated infectious disorders are but different forms of lyme borreliosis. a challenge for the clinician and microbiology laboratory is confirmation that a skin rash, a chronic meningitis, an episode of myocarditis, or an a ... | 1988 | 3069200 |
| [intermittent fever attacks. lyme disease without erythema chronicum migrans]. | | 1988 | 3069790 |
| [multiple neurologic manifestations of borrelia burgdorferi infection]. | the neurological spectrum of borrelia burgdorferi infections is still enlarging. we review epidemiological, pathological and serological data of lyme disease. the course of the disease is divided in three stages: stage 1 during the first month is characterised by erythema chronicum migrans and associated manifestations; stage 2 includes not only the classical european meningoradiculitis but also less specific neurological symptoms: isolated lymphocytic meningitis with an acute or even relapsing ... | 1988 | 3070690 |
| [a new type of spirochete infection: lyme disease]. | | 1988 | 3071626 |
| [cutaneous b cell lymphoma in chronic borrelia burgdorferi infection. report of 2 cases and a review of the literature]. | low-grade malignant b-cell lymphomas of the skin can be distinguished from lymphadenosis benigna cutis (bäfverstedt) by immunohistological methods developed in the last few years. its coexistence with borrelia burgdorferi infection can be shown by clinical and serological findings. in the chronic stage of this infection, lymphocytic cell infiltrations consistent with histological and immunohistological findings of malignant b-cell lymphoma can be found. predominantly at the extremities, multiple ... | 1988 | 3072322 |
| [identification of borrelia isolated in the ussr from ixodes persulcatus schulze ticks]. | the data on the identification of 7 spirochetal isolates from ixodes persulcatus ticks collected in leningrad province and the khabarovsk territory are presented. these isolates, studied with the use of monoclonal antibodies, have been shown to belong to borrelia burgdorferi. | 1988 | 3072807 |
| lyme disease in canada? | | 1986 | 3079659 |
| lyme disease in a hampshire child--medical curiosity or beginning of an epidemic? | | 1986 | 3087517 |
| [sinoatrial and atrioventricular conduction disorders in lyme disease. apropos of 2 case reports]. | lyme's disease due to borrelia burgdorferii is a rare cause of acute atrioventricular block (avb) which is the commonest cardiac complication. cutaneous, neurological and articular involvement complete the clinical picture of this condition. these two cases, confirmed by serology, support previously reported data describing the favourable prognosis of these conduction defects (suprahisian and/or hisian in our 2 cases) which regress completely, irrespective of their degree of severity. the author ... | 1986 | 3101641 |
| oligoclonal antibodies in csf of patients with meningopolyneuritis garin-bujadoux-bannwarth: ig class, light chain type and specificity. | detection of intrathecally produced antibodies in cerebrospinal fluid (csf) of patients with meningopolyneuritis garin-bujadoux-bannwarth (mpn-gbb) is well documented. analysis of csf has revealed the oligoclonal nature of these antibodies. we investigated oligoclonal antibodies (oa) in csf and serum of mpn-gbb patients with regard to immunoglobulin class, light chain type and specificity and compared the findings with those in other neurological diseases (ond). for this purpose an immunofixatio ... | 1987 | 3109143 |
| treatment and course of erythema chronicum migrans. | 72 patients with erythema chronicum migrans were treated with phenoxymethyl penicillin, 1,5 mill. iu p.o. three times a day for 14 days. two children got the same therapy, but in a dosage of 400,000 iu three times a day for 10 days. in three of 15 skin samples, taken from the periphery of ecm lesions, spirochetal organisms were isolated. of the 72 patients 16 had raised igg (greater than or equal to 128) and 9 had raised igm (greater than or equal to 64) titers to borrelia burgdorferi. under tre ... | 1987 | 3109145 |
| borrelia burgdorferi in a newborn despite oral penicillin for lyme borreliosis during pregnancy. | | 1988 | 3130607 |
| [thrombocytopenic purpura caused by borrelia burgdorferi?]. | in november 1983 a woman born in 1902 was found to have thrombocytopenic purpura with a platelet count of 14,000/microliter. examination of the sternal marrow resulted in a suspected diagnosis of werlhof's disease. platelet counts dropped at times to below 7,000/microliter during immunosuppressive treatment with corticosteroids and azathioprine of three months' duration. when this treatment was discontinued spontaneous remission occurred until july 1984. acrodermatitis chronica atrophicans was d ... | 1988 | 3133191 |
| [case report of lyme disease showing large erythematous lesion in the abdomen]. | | 1988 | 3138324 |
| lyme disease with acute purulent meningitis. | | 1988 | 3139148 |
| broad-host-range plasmid and m13 bacteriophage-derived vectors for promoter analysis in escherichia coli and pseudomonas aeruginosa. | a set of bacteriophage and plasmid vectors containing xyle as a reporter gene was constructed for the analysis of promoters functional in escherichia coli and in other gram-negative bacteria. two m13 bacteriophage derivatives, m13mvdx18 and m13mmk010, were designed for rapid cloning, screening and sequencing of dna fragments promoting transcription in e. coli. to demonstrate their utility, total cellular dna from a variety of bacterial species including pseudomonas aeruginosa strain pao was shot ... | 1988 | 3149945 |
| the use of doxycycline in nervous system borrelia burgdorferi infection. | alternatives to high dose benzylpenicillin treatment are sought for in patients with mild borrelia burgdorferi nervous system infection. doxycycline 100 mg twice daily for 10-20 days was used in nine patients with radicular pains, vertigo or weakness in the legs caused by b. burgdorferi infection. the patients had suffered from neurologic symptoms for a median time of five months. in eight patients doxycycline was orally administered and in one intravenously. all nine patients had remission of r ... | 1988 | 3166545 |
| intensity and duration of borrelia burgdorferi and babesia microti infectivity in rodent hosts. | | 1988 | 3170076 |
| relapsing fever (borrelia) in an adolescent tourist in israel. | a case of an adolescent tourist who contracted relapsing fever (borrelia) in israel is presented. travel in an infested area, a fever of irregular nature, and a strong history of tick bites are clues to diagnosis. | 1988 | 3170308 |
| ticks and biting insects infected with the etiologic agent of lyme disease, borrelia burgdorferi. | members of 18 species of ticks, mosquitoes, horse flies, and deer flies were collected in southeastern connecticut and tested by indirect fluorescent-antibody staining methods for borrelia burgdorferi, the etiologic agent of lyme disease. an infection rate of 36.2% (116 tested), recorded for immature ixodes dammini, exceeded positivity values for all other arthropod species. prevalence of infection for hematophagous insects ranged from 2.9% of 105 hybomitra lasiophthalma to 14.3% of seven hybomi ... | 1988 | 3170711 |
| lyme borreliosis in the soviet union: a cooperative us-ussr report. | we identified 90 patients with tick-borne erythema migrans in the union of soviet socialist republics (ussr) in areas from the western baltic republics to the maritime territory on the pacific ocean. symptoms associated with the erythema included fever, malaise and fatigue, headache, myalgias, arthralgias, or regional lymphadenopathy. within two weeks to four months, 58 (64%) of the patients developed neurological abnormalities, particularly radicular pain, cranial neuritis, or lymphocytic menin ... | 1988 | 3171226 |
| cultivation of borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to lyme borreliosis. | | 1988 | 3171237 |
| [clinical picture of the acute period in tick-borne lyme borreliosis]. | | 1988 | 3173244 |
| [chronic atrophic acrodermatitis as a late manifestation of lyme borreliosis]. | | 1988 | 3174136 |
| characterization of a circular plasmid from borrelia burgdorferi, etiologic agent of lyme disease. | borrelia burgdorferi, the etiologic agent of lyme disease, was recently shown to contain plasmid dna. two plasmid species have been described in strain ct1, a wisconsin tick isolate: a 9.2-kilobase entity; and a larger, 70-kilobase entity. characterization of the 9.2-kilobase entity by using dnase i and restriction endonucleases demonstrated that the plasmid is supercoiled and exists as a stable dimer in this strain. the role played by the plasmid in b. burgdorferi is unknown. | 1988 | 3183006 |
| new borrelia burgdorferi antigenic variant isolated from ixodes dammini from upstate new york. | a previously undescribed borrelia burgdorferi antigenic variant was isolated from each of four ixodes dammini larvae removed from white-footed mice, peromyscus leucopus, captured in millbrook, n.y. this site is in the northern range of the known distribution of the tick in the northeastern united states. the molecular weights of approximately 32,500 and 35,500 for outer surface a and outer surface b proteins, respectively, were distinctly higher than those for previously characterized isolates f ... | 1988 | 3183008 |
| optic neuropathy in borrelia infection. | | 1988 | 3183410 |
| [ocular findings in tick borreliosis]. | tick-transmitted borreliosis is by no means a rare infectious disease. it is found especially in southern parts of germany. eyes are seldom affected. the disease can lead to nerve palsy of the eye muscles. one case of panophthalmitis and one of optic disk edema have been described. the authors found a bilateral palsy of the abducens nerve in one patient with tick-transmitted borreliosis. motility normalized under therapy with highly-dosed penicillin. | 1988 | 3184742 |
| [recurrent fevers]. | | 1988 | 3187258 |
| [epidemiology of lyme disease]. | | 1988 | 3187264 |
| [borrelia burgdorferi encephalomyelitis]. | we report two patients with chronic encephalomyelitis due to borrelia burgdorferi in whom the definite diagnosis was delayed because of atypical clinical features. the first patient presented with chronic spastic paraparesis, slight ataxia and nystagmus of several years' duration. a tentative diagnosis of multiple sclerosis was made in spite of important abnormalities of the csf biological characteristics. the second patient presented with an acute aphasia and a bilateral babinski's sign. he was ... | 1988 | 3187297 |
| lyme disease and related disorders. | | 1988 | 3190087 |
| lyme disease: antigens of borrelia burgdorferi and immune responses to them. | | 1988 | 3190088 |
| the genes encoding major surface proteins of borrelia burgdorferi are located on a plasmid. | | 1988 | 3190089 |
| development of borrelia burgdorferi in ixodid tick vectors. | | 1988 | 3190091 |
| prospects for suppressing transmission of lyme disease. | a variety of methods have been developed to prevent human infection by the lyme disease spirochete in the northeastern united states, mainly based on the observations that nymphal ixodes dammini serve as vector, that deer serve as hosts for the reproductive stage of this tick, that white-footed mice serve as the reservoir of infection, and that nymphs are most abundant in early summer and must attach for 2 days before infection is transmitted. methods for personal protection included seasonal av ... | 1988 | 3190093 |
| host responses to borrelia burgdorferi in dogs and horses. | by using paired sera the igm and igg host responses were analyzed in dogs with elisa and western blot techniques. antibodies in clinical seropositive dogs bound to 4-25 igm and up to 40 or more igg antigenic determinants. early igm response to the 41-kda flagellin persisted for at least 9 months and involved as many as seven other peptides. igg response expanded later in the disease and involved more immunogens than are currently recognized in late human disease. a percentage of asymptomatic dog ... | 1988 | 3190094 |
| borrelia burgdorferi infection in wisconsin horses and cows. | blood samples from wisconsin horses and cows suspected of having clinical disease due to borrelia burgdorferi infection were submitted by veterinary practitioners. all serum, milk, colostrum, and synovial samples were tested for b. burgdorferi antibodies by immunofluorescence. whole blood, milk, colostrum, and synovial fluid samples were cultured for b. burgdorferi. records were kept on the clinical signs of antibody-positive animals, date of sample, and location of the animal by county. of the ... | 1988 | 3190095 |
| epidemiologic studies of lyme disease in horses and their public health significance. | a serologic survey of horses in the new jersey-pennsylvania area demonstrated that about 10% (6.2-14.2%) have significant levels of serum antibody to borrelia burgdorferi. however, in a highly endemic area of central new jersey, up to 60% of the mares and yearlings samples on one farm were seropositive. in 1983, sera from this same farm exhibited only 12% positives in mares and 35% positives in yearlings. longitudinal studies of paired sera obtained from individual yearlings over a 6-month perio ... | 1988 | 3190097 |
| experimental infection of the hamster with borrelia burgdorferi. | | 1988 | 3190098 |
| occupational risk of lyme disease in endemic areas of new york state. | although lyme disease (ld) is the most common tick-borne disease in the united states, little is known about the frequency of and risk factors for infection with borrelia burgdorferi in occupational groups. in 1986, we recruited primarily outdoor workers from six employee groups in southeastern new york where ld is endemic. of 414 participants who completed questionnaires and had blood samples tested for antibodies against b. burgdorferi by elisa and western immunoblot, 27 (6.5%) were seropositi ... | 1988 | 3190100 |
| clinical manifestations and epidemiological characteristics of lyme disease in hailin county, heilongjiang province, china. | clinical manifestations and epidemiological characteristics of lyme disease in hailin county, heilongjiang province, china have been reported. the clinical picture of erythema chronicum migrans (ecm) is variable. ecm in the form of annular erythematous patch is uncommon. it is an extensive and indurated lesion. in some instances, a vesicle or necrosis appears in the center of the lesion. secondary erythema may present in some patients. the neurologic abnormalities consist of meningitis, facial p ... | 1988 | 3190101 |
| clinical manifestations and diagnosis of neuroborreliosis. | lyme borreliosis has in a few years turned out to be a health problem not only in the united states, but also in many european countries. when it affects the nervous system, lyme borreliosis acts as the great disease imitator. because of this characteristic it is often difficult to diagnose on clinical grounds. patients with neuroborreliosis might appear within all medical disciplines. clinical markers, such as preceding tick bite and/or ecm, are important clues to the diagnosis. mononuclear ple ... | 1988 | 3190103 |
| borrelia burgdorferi in the nervous system: the new "great imitator". | there are many obvious similarities between lyme disease and syphilis. the major ones are their spirochetal etiology, the ability of the spirochetes to stay alive in human tissue for years, occurrence of clinical manifestations in stages, early disease in the skin and later disease in the brain, and susceptibility to antibiotic treatment. thus, one can assume that many of the same lessons learned from the centuries of experience with syphilis will apply to lyme disease. one of these lessons that ... | 1988 | 3190104 |
| first isolations of borrelia burgdorferi from rodents collected in northern europe. | spirochetes were found in 13% of ixodes ricinus collected from an island, near stockholm where human borreliosis is endemic. borrelia burgdorferi was cultivated from the kidney and/or spleen of wild rodents (clethrionomys glareolus and apodemus flavicollis) from the same island. spirochetes were identified as borrelia burgdorferi by indirect immunofluorescence assays using species and genus specific monoclonal antibodies. in these tests the spirochetes could not be differentiated from strains pr ... | 1988 | 3190915 |
| relapsing fever in pregnancy: analysis of high-risk factors. | the diagnosis of tick-borne relapsing fever was established in 27 pregnant patients by demonstration of borrelia spirochaetes in a thick blood smear and the borrelia index was estimated to calculate the density of the spirochaetaemia. clinical findings are described and compared with those reported from rwanda. the results suggest that the density of the spirochaetaemia and the gestational age are the main high-risk factors. | 1988 | 3191046 |
| [lymphocytic meningoradiculitis (bannwarth's syndrome)]. | | 1988 | 3191865 |
| neuroborreliosis in morphea and lichen sclerosus et atrophicus. | nine cases of different types of morphea and two of lichen sclerosus et atrophicus were investigated for the presence of neurologic symptoms. the borrelia origin of morphea and lichen sclerosus et atrophicus was verified by the presence of antibodies against borrelia burgdorferi and by the visualization of spirochetes on histologic sections by immunohistochemical methods. one patient had intrathecally synthesized igg antibodies against b. burgdorferi that indicated intrathecal infection. a secon ... | 1988 | 3192771 |
| ability to ixodes scapularis, dermacentor variabilis, and amblyomma americanum (acari: ixodidae) to acquire, maintain, and transmit lyme disease spirochetes (borrelia burgdorferi). | | 1988 | 3193425 |
| ixodes dammini: occurrence and prevalence of infection with borrelia spp. in minnesota. | the distribution of ixodes dammini in minnesota was studied by collecting adult ticks from hunting dogs during the grouse seasons in september and october of 1985 and 1986. the tick was most frequently found in the east-central part of the state. borrelia spp. were observed by immunofluorescence in 10% of the ticks. the locations where ticks were found coincide with the primary endemic areas for lyme disease in the state. | 1988 | 3193571 |
| diagnosing lyme disease: the contribution of serologic testing. | lyme disease is a multisystem disorder caused by a tick-transmitted spirochete, borrelia burgdorferi. the diagnosis is based on clinical findings in most patients, particularly those with erythema migrans or exposure to geographic locations endemic for the disease. detection of a specific antibody to b. burgdorferi is a useful confirmatory test in many patients. in atypical cases, however, a positive test result can be pivotal for determining the diagnosis and can lead to institution of definiti ... | 1988 | 3193820 |
| [the results of clinico-immunologic research on patients with tick-borne lyme borreliosis]. | | 1988 | 3193922 |
| [predominant involvement of the central nervous system in a secondary form of borreliosis]. | the clinical features of a patient with a secondary stage of borrelia burgdorferi infection are reported. severe symptoms and signs of central nervous involvement were present. | 1988 | 3194610 |
| greater risk of borrelia burgdorferi infection in dogs than in people. | | 1988 | 3198950 |
| lyme borreliosis in romania. | | 1988 | 3202685 |
| lyme disease in italy: isolation of borrelia burgdorferi from a patient. | a strain of borrelia burgdorferi was isolated from a 48-year-old female patient suffering from a chronic form of polyarthritis. significant titers of specific anti-borrelia antibodies were not found. this is the first report of isolation of borrelia burgdorferi from a patient in italy. | 1988 | 3203735 |
| seroconversion to borrelia burgdorferi in a patient with juvenile arthritis in ontario, canada. | a seroconversion to borrelia burgdorferi, the etiological agent of lyme disease, was documented in a 5 year old girl from central ontario. our patient developed juvenile arthritis in january, 1984 when she was 14 months old. it was relatively well controlled with aspirin. her arthritis flared in april, 1986 at which time seroconversion to b. burgdorferi was demonstrated by indirect immunofluorescence and by enzyme linked immunosorbent assay. she was treated with phenoxymethyl penicillin and has ... | 1988 | 3204603 |
| [antibody activity of csf oligoclonal igg in infectious neurological diseases. detection using immunoblotting]. | the authors describe various applications of an immunoblot technique which allows the qualitative determination of the specific antibody activity of oligoclonal igg intrathecally synthesized in infectious diseases of the nervous system. after dilution of sera to the same igg concentration as the paired csf samples, 10 microliters of both fluids are applied side by side on agarose gel plates and isoelectrically focused. precipitated igg or specific igg antibodies are then blotted onto a nitrocell ... | 1988 | 3206996 |