| zika virus disease and associated neurologic complications. | the purpose of this article is to review what is currently known about zika virus (zikv) disease and associated neurologic complications. | 2017 | 28220392 |
| zika virus: an overview. | the zika virus has been in the news for quite some time due to the ongoing recent outbreak in the southern america, which started in december 2015. it has been declared a public health emergency by the world health organization in february 2016 owing to its association with the congenital deformities, particularly microcephaly in infants borne to the infected mothers. the rapid spread of the virus throughout the united states of america and subsequently to asia has raised serious international c ... | 2017 | 28217576 |
| zika virus: transmission, detection, control, and prevention. | zika virus (zikv) is a mosquito-borne flavivirus discovered in uganda in the 1940s. to date, three major zikv outbreaks have been reported. zikv infections have known to be primarily asymptomatic while causing mild illness in a few cases. however, the recent emergence and spread of zikv in the americas has resulted in the declaration of "public health emergency of international concern" due to the potential association between the infection and prenatal microcephaly or other brain anomalies. in ... | 2017 | 28217114 |
| differential responses of human fetal brain neural stem cells to zika virus infection. | zika virus (zikv) infection causes microcephaly in a subset of infants born to infected pregnant mothers. it is unknown whether human individual differences contribute to differential susceptibility of zikv-related neuropathology. here, we use an asian-lineage zikv strain, isolated from the 2015 mexican outbreak (mex1-7), to infect primary human neural stem cells (hnscs) originally derived from three individual fetal brains. all three strains of hnscs exhibited similar rates of mex1-7 infection ... | 2017 | 28216147 |
| challenges in fetal surveillance of pregnant women with zika virus. | | 2017 | 28209337 |
| analysis of blood from zika virus-infected fetuses: a prospective case series. | zika virus has spread through the americas and the caribbean since early 2015 and was rapidly declared a public health emergency of international concern by who because of the potential association with fetal anomalies. we analysed fetal and maternal fluids and tissues in fetuses with confirmed zika virus infection prospectively monitored in martinique, a french caribbean island. | 2017 | 28209336 |
| the ins and outs of eukaryotic viruses: knowledge base and ontology of a viral infection. | viruses are genetically diverse, infect a wide range of tissues and host cells and follow unique processes for replicating themselves. all these processes were investigated and indexed in viralzone knowledge base. to facilitate standardizing data, a simple ontology of viral life-cycle terms was developed to provide a common vocabulary for annotating data sets. new terminology was developed to address unique viral replication cycle processes, and existing terminology was modified and adapted. the ... | 2017 | 28207819 |
| transmission of zika virus - haiti, october 12, 2015-september 10, 2016. | zika virus disease is caused by infection with a flavivirus with broad geographic distribution and is most frequently transmitted by the bite of an infected mosquito. the disease was first identified in the world health organization's region of the americas in 2015 and was followed by a surge in reported cases of congenital microcephaly in brazil; zika virus disease rapidly spread to the rest of the region and the caribbean (1), including haiti. infection with the virus is associated with advers ... | 2017 | 28207688 |
| engaging human rights in the response to the evolving zika virus epidemic. | in late 2015, an increase in the number of infants born with microcephaly in poor communities in northeast brazil prompted investigation of antenatal zika infection as the cause. zika now circulates in 69 countries, and has affected pregnancies of women in 29 countries. public health officials, policymakers, and international organizations are considering interventions to address health consequences of the zika epidemic. to date, public health responses have focused on mosquito vector eradicatio ... | 2017 | 28207337 |
| leaking containers: success and failure in controlling the mosquito aedes aegypti in brazil. | in 1958, the pan american health organization declared that brazil had successfully eradicated the mosquito aedes aegypti, responsible for the transmission of yellow fever, dengue fever, chikungunya, and zika virus. yet in 2016 the brazilian minister of health described the situation of dengue fever as "catastrophic." discussing the recent epidemic of zika virus, which amplified the crisis produced by the persistence of dengue fever, brazil's president declared in january 2016 that "we are in th ... | 2017 | 28207332 |
| does zika virus infection affect mosquito response to repellents? | the world health organization (who) recommends that people travelling to or living in areas with zika virus (zikv) outbreaks or epidemics adopt prophylactic measures to reduce or eliminate mosquito bites, including the use of insect repellents. it is, however, unknown whether repellents are effective against zikv-infected mosquitoes, in part because of the ethical concerns related to exposing a human subject's arm to infected mosquitoes in the standard arm-in-cage assay. we used a previously dev ... | 2017 | 28205633 |
| response to "associated ultrasonographic findings in fetuses with microcephaly because of suspected zika virus (zikv) infection during pregnancy". | | 2017 | 28205302 |
| comment on "associated ultrasonographic findings in fetuses with microcephaly because of suspected zika virus (zikv) infection during pregnancy". | | 2017 | 28205300 |
| zika virus (zikv), global public health, disability, and rehabilitation: connecting the dots…. | | 2017 | 28204734 |
| sulfated glycans and related digestive enzymes in the zika virus infectivity: potential mechanisms of virus-host interaction and perspectives in drug discovery. | as broadly reported, there is an ongoing zika virus (zikv) outbreak in countries of latin america. recent findings have demonstrated that zikv causes severe defects on the neural development in fetuses in utero and newborns. very little is known about the molecular mechanisms involved in the zikv infectivity. potential therapeutic agents are also under investigation. in this report, the possible mechanisms of action played by glycosaminoglycans (gags) displayed at the surface proteoglycans of ho ... | 2017 | 28203251 |
| structural features of zika virus non-structural proteins 3 and -5 and its individual domains in solution as well as insights into ns3 inhibition. | zika virus (zikv) has emerged as a pathogen of major health concern. the virus relies on its non-structural protein 5 (ns5) including a methyl-transferase (mtase) and a rna-dependent rna polymerase (rdrp) for capping and synthesis of the viral rna and the nonstructural protein 3 (ns3) with its protease and helicase domain for polyprotein possessing, unwinding dsrna proceeding replication, and ntpase/rtpase activities. in this study we present for the first time insights into the overall structur ... | 2017 | 28202376 |
| real-time assessment of health-care requirements during the zika virus epidemic in martinique. | | 2017 | 28200111 |
| frequent zika virus sexual transmission and prolonged viral rna shedding in an immunodeficient mouse model. | circulation of zika virus (zikv) was first identified in the western hemisphere in late 2014. primarily transmitted through mosquito bite, zikv can also be transmitted through sex and from mother to fetus, and maternal zikv infection has been associated with fetal malformations. we assessed immunodeficient ag129 mice for their capacity to shed zikv in semen and to infect female mice via sexual transmission. infectious virus was detected in semen between 7 and 21 days post-inoculation, and zikv r ... | 2017 | 28199846 |
| [risk of transmission of zika virus in spain: an experience in a health department]. | | 2017 | 28198171 |
| neonatal pigs are susceptible to experimental zika virus infection. | | 2017 | 28196970 |
| a cdna clone-launched platform for high-yield production of inactivated zika vaccine. | a purified inactivated vaccine (piv) using the zika virus (zikv) puerto rico strain prvabc59 showed efficacy in monkeys, and is currently in a phase i clinical trial. high-yield manufacture of this piv is essential for its development and vaccine access. here we report an infectious cdna clone-launched platform to maximize its yield. a single ns1 protein substitution (k265e) was identified to increase zikv replication on vero cells (a cell line approved for vaccine production) for both cambodian ... | 2017 | 28196656 |
| persistence of zika virus in body fluids - preliminary report. | background to estimate the frequency and duration of detectable zika virus (zikv) rna in human body fluids, we prospectively assessed a cohort of newly infected participants in puerto rico. methods we evaluated samples obtained from 150 participants (including 55 men) in whom zikv rna was detected on reverse-transcriptase-polymerase-chain-reaction (rt-pcr) assay in urine or blood in an enhanced arboviral clinical surveillance site. we collected serum, urine, saliva, semen, and vaginal secretions ... | 2017 | 28195756 |
| relative analytical sensitivity of donor nucleic acid amplification technology screening and diagnostic real-time polymerase chain reaction assays for detection of zika virus rna. | zika virus (zikv) has spread rapidly in the pacific and throughout the americas and is associated with severe congenital and adult neurologic outcomes. nucleic acid amplification technology (nat) assays were developed for diagnostic applications and for blood donor screening on high-throughput nat systems. we distributed blinded panels to compare the analytical performance of blood screening relative to diagnostic nat assays. | 2017 | 28194799 |
| vulnerability of primitive human placental trophoblast to zika virus. | infection of pregnant women by asian lineage strains of zika virus (zikv) has been linked to brain abnormalities in their infants, yet it is uncertain when during pregnancy the human conceptus is most vulnerable to the virus. we have examined two models to study susceptibility of human placental trophoblast to zikv: cytotrophoblast and syncytiotrophoblast derived from placental villi at term and colonies of trophoblast differentiated from embryonic stem cells (esc). the latter appear to be analo ... | 2017 | 28193876 |
| simple and highly sensitive molecular diagnosis of zika virus by lateral flow assays. | we have developed a simple, user-friendly, and highly sensitive zika virus (zikv) detection method by incorporating optimized reverse transcription loop-mediated isothermal amplification (rt-lamp) and a lateral flow assay (lfa). the optimized rt-lamp reaction was carried out using bst 3.0 polymerase, which has robust and fast isothermal amplification performance even in the presence of high concentrations of inhibitors; this permitted the amplification of zikv rna in pure water and human whole b ... | 2016 | 28193014 |
| holding back the tiger: successful control program protects australia from aedes albopictus expansion. | the asian tiger mosquito, aedes albopictus, is an important vector of dengue, chikungunya and zika viruses and is a highly invasive and aggressive biter. established populations of this species were first recognised in australia in 2005 when they were discovered on islands in the torres strait, between mainland australia and papua new guinea. a control program was implemented with the original goal of eliminating ae. albopictus from the torres strait. we describe the evolution of management stra ... | 2017 | 28192520 |
| persistence of zika virus in breast milk after infection in late stage of pregnancy. | we detected zika virus in breast milk of a woman in brazil infected with the virus during the 36th week of pregnancy. virus was detected 33 days after onset of signs and symptoms and 9 days after delivery. no abnormalities were found during fetal assessment or after birth of the infant. | 2017 | 28192072 |
| strengthening health systems through international blood product sharing agreements. | blood products are critical to the success of both routine healthcare delivery and emergency response efforts. ensuring the safety and availability of blood products presents nations with considerable collection, screening, and distribution challenges that are often exacerbated by public health crises, particularly mass-casualty events involving traumatic injuries. however, recent outbreaks of ebola and zika virus disease have also illustrated the importance of securing blood product supplies du ... | 2017 | 28192051 |
| zika virus: a pandemic in progress. | the world is facing a number of emerging infections. the latest outbreak of zika virus infection has only added to the suffering. the who declared a state of emergency in the affected countries and has issued alarms worldwide. the paucity of literature leading to lack of clear guidelines is one of the most important factors resulting in a higher number of cases. the absence of clinical vaccine and an antiviral drug may prove to be a really grave situation. the present paper throws some light on ... | 2016 | 28191517 |
| evaluation of possible consequences of zika virus infection in the developing nervous system. | the zika virus (zikv) outbreak that occurred in the northeast of brazil in 2015 led to alarming numbers of babies born with microcephaly in this region. since then, several studies have evaluated the relationship between zikv infection and development of the malformation although the specific mechanistic interaction between zikv and human physiological processes that ultimately manifest as microcephaly remains debated. importantly, most current studies did not consider the specificities of the b ... | 2017 | 28190239 |
| [zika fever]. | zika virus infection is an emerging arboviral disease which presented as a mild flu-like or algo-eruptive syndrome with fever, arthralgia, myalgia and a maculopapulous eruption. severe neurological and fetal complications have recently been highlighted. diagnosis is established by detection of viral rna by reverse transcriptase-polymerase chain reaction (rt-pcr). many publications report on the progress of knowledge on zika and its complications. treatment is symptomatic, mainly with analgesics. ... | 2017 | 28189390 |
| [ocular manifestations of zika virus: what we do and do not know]. | zika virus (zikv) disease outbreak, which was declared by the end of 2015 in brazil, has become the largest one to date. being reported in the americas and in certain islands of the pacific, it has the potential to spread worldwide. although zikv infections are mostly self-limiting and/or asymptomatic in the healthy adult, they are responsible for devastating congenital neurologic malformations zikv (mainly microcephaly) when contracted during the first months of pregnancy. ocular manifestations ... | 2017 | 28189347 |
| zika virus infection and myasthenia gravis: report of 2 cases. | | 2017 | 28188305 |
| what kaplan-meier survival curves don't tell us about cns disease. | central nervous system consequences of viral infections are rare, but when they do occur, they are often serious and clinically challenging to manage. our awareness of the perils of neuroinvasion by viruses is growing: the recently appreciated impact of ebola and zika virus infections on cns integrity, decreases in vaccination coverage for potentially neurotropic viruses such as measles, and increased neurovirulence of some influenza strains collectively highlight the need for a better understan ... | 2017 | 28187911 |
| laboratory strains of aedes aegypti are competent to brazilian zika virus. | the zika virus outbreaks are unprecedented human threat in relation to congenital malformations and neurological/autoimmune complications. since this virus has high potential to spread in regions presenting the vectors, improvement in mosquito control is a top priority. thus, aedes aegypti laboratory strains will be fundamental to support studies in different research fields implicated on zika-mosquito interactions which are the basis for the development of innovative control methods. in this se ... | 2017 | 28187183 |
| characteristics of zika virus disease in children: clinical, hematological and virological findings from an outbreak in singapore. | | 2017 | 28186536 |
| prevention and control of dengue-the light at the end of the tunnel. | advances in the development of new dengue control tools, including vaccines and vector control, herald a new era of desperately needed dengue prevention and control. the burden of dengue has expanded for decades, and now affects more than 120 countries. complex, large-scale global forces have and will continue to contribute to the expansion of dengue, including population growth, unplanned urbanisation, and suboptimal mosquito control in urban centres. although no so-called magic bullets are ava ... | 2017 | 28185870 |
| novel antiviral activity and mechanism of bromocriptine as a zika virus ns2b-ns3 protease inhibitor. | zika virus (zikv) infection is associated with congenital malformations in infected fetuses and severe neurological and other systemic complications in adults. there are currently limited anti-zikv treatment options that are readily available and safe for use in pregnancy. in this drug repurposing study, bromocriptine was found to have inhibitory effects on zikv replication in cytopathic effect inhibition, virus yield reduction, and plaque reduction assays. time-of-drug-addition assay showed tha ... | 2017 | 28185815 |
| zika virus and blood transfusion: the experience of french polynesia. | between october 2013 and march 2014, french polynesia experienced the largest zika virus (zikv) outbreak ever described before the emergence of zikv in the americas in 2015. as arbovirus transfusion-transmitted (tt) infections have been previously reported, we hypothesized that transfusion of blood products could also transmit zikv. | 2017 | 28185278 |
| zika virus pathogenesis and tissue tropism. | although zika virus (zikv) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. the recent spread of zikv to countries in the western hemisphere is associated with reports of microcephaly, congenital malformations, and guillain-barré syndrome. this has resulted in zikv being declared a public health emergency and has greatly accelerated the pace of zikv research and discovery. within a short time period, useful mouse and non-human primate disease mo ... | 2017 | 28182948 |
| prevalence and clinical attributes of congenital microcephaly - new york, 2013-2015. | congenital zika virus infection can cause microcephaly and other severe fetal neurological anomalies (1). to inform microcephaly surveillance efforts and assess ascertainment sources, the new york state department of health and the new york city department of health and mental hygiene sought to determine the prevalence of microcephaly in new york during 2013-2015, before known importation of zika virus infections. suspected newborn microcephaly diagnoses were identified from 1) reports submitted ... | 2017 | 28182608 |
| predicting the potential role of non-human hosts in zika virus maintenance. | arboviruses are often maintained in complex cycles involving vertebrates such as mammals or birds and blood-feeding mosquitoes. however, the role of wildlife hosts in their emergence or re-emergence in human populations has received little attention. the recent emergence of zika virus in america, and previous occurrences of chikungunya and dengue, forces us to confront a potential new disease-emergence phenomenon. using a spatial data mining framework to identify potential biotic interactions, b ... | 2017 | 28180996 |
| the antigenic structure of zika virus and its relation to other flaviviruses: implications for infection and immunoprophylaxis. | zika virus was discovered ∼70 years ago in uganda and maintained a low profile as a human disease agent in africa and asia. only recently has it caused explosive outbreaks in previously unaffected regions, first in oceania and then in the americas since 2015. of special concern is the newly identified link between congenital malformations (especially microcephaly) and zika virus infections during pregnancy. at present, it is unclear whether zika virus changed its pathogenicity or whether the hug ... | 2017 | 28179396 |
| zika virus: practical information for the plastic and reconstructive surgeon. | the ongoing zika virus outbreak in south, central, and, most recently, north america has become a global health care emergency. originally thought to be a benign, self-limiting viral syndrome, the newest epidemic has provided convincing evidence that maternal zika virus infection can lead to neonatal malformations, the so-called congenital zika syndrome. the alarming number of microcephalic neonates being born during the current outbreak is most notable, though several other anomalies, such as a ... | 2017 | 28177969 |
| development of a high-throughput colorimetric zika virus infection assay. | zika virus (zikv) is an emerging pathogen that causes congenital infections which may result in birth defects, such as microcephaly. currently, no approved treatment or vaccination is available. zikv can be readily detected in cell culture where virally infected cells are normally stained by specific antibodies. as zikv regularly causes a cytopathic effect, we were wondering whether this viral property can be used to quantitatively determine viral infectivity. we here describe the use of an 3-[4 ... | 2017 | 28176006 |
| does zika virus infection induce prolonged remissions in children with idiopathic nephrotic syndrome? | zika is an emerging mosquito-borne flavivirus. we report two pediatric patients diagnosed with idiopathic nephrotic syndrome who achieved complete remission of the disease after suffering zika virus (zikv) infection. | 2017 | 28175986 |
| zika virus serology: more diagnostic targets, more reliable answers? | | 2017 | 28174133 |
| zika: how safe is india? | zika virus, which originated from a forest in uganda, has affected countries in africa, latin america and asia. most people infected with zika are asymptomatic and present with clinical manifestations ranging from mild fever to severe neurological disorders. recent outbreaks in southeast asian countries, centers for disease control and prevention has warned pregnant woman to avoid nonessential traveling to 11 asian countries. reports about the sexual transmission route of zika have pushed the wo ... | 2017 | 28173851 |
| larvicidal activity of blumea eriantha essential oil and its components against six mosquito species, including zika virus vectors: the promising potential of (4e,6z)-allo-ocimene, carvotanacetone and dodecyl acetate. | the effective and environmentally sustainable control of mosquitoes is a challenge of essential importance. this is due to the fact that some invasive mosquitoes, with special reference to the aedes genus, are particularly difficult to control, due to their high ecological plasticity. moreover, the indiscriminate overuse of synthetic insecticides resulted in undesirable effects on human health and non-target organisms, as well as resistance development in targeted vectors. here, the leaf essenti ... | 2017 | 28168560 |
| using twitter to identify and respond to food poisoning: the food safety stl project. | foodborne illness affects 1 in 4 us residents each year. few of those sickened seek medical care or report the illness to public health authorities, complicating prevention efforts. citizens who report illness identify food establishments with more serious and critical violations than found by regular inspections. new media sources, including online restaurant reviews and social media postings, have the potential to improve reporting. | 2017 | 28166175 |
| first zika-positive donations in the continental united states. | zika virus (zikv) has spread in the americas, including parts of the southern united states, and infection can be associated with serious complications, including congenital brain abnormalities. probable transfusion transmission of zikv has been documented in brazil. | 2017 | 28164310 |
| amustaline (s-303) treatment inactivates high levels of zika virus in red blood cell components. | the potential for zika virus (zikv) transfusion-transmission (tt) has been demonstrated in french polynesia and brazil. pathogen inactivation (pi) of blood products is a proactive strategy to inactivate tt pathogens including arboviruses. inactivation of west nile, dengue, zika, and chikungunya viruses was previously demonstrated by photochemical treatment with amotosalen and ultraviolet a (uva) illumination. in this study, we evaluated zikv inactivation in red blood cell (rbc) components by a c ... | 2017 | 28164306 |
| risk of exposure to blood products during pregnancy: guidance for zika and other donor deferral policies. | exposure to blood products during pregnancy carries a potential risk of transfusion transmission of infectious agents. blood agencies have historically sought optimal deferral and testing strategies to protect blood supplies in part to ensure the protection of pregnant women and their unborn infants. the zika virus outbreak of 2016 has heightened attention to these concerns. in the current context of the recent zika outbreak, and also more broadly, data are needed to shed light on the likelihood ... | 2017 | 28164300 |
| fetal magnetic resonance imaging of fetus with zika virus infection. | | 2017 | 28160965 |
| 'preventing the zika virus: understanding and controlling the aedes mosquito' - a free online course. | | 2017 | 28159620 |
| global performance of epidemiologic surveillance of zika virus: rapid assessment of an ongoing epidemic. | | 2017 | 28159022 |
| estimated zika virus importations to europe by travellers from brazil. | background given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. design we applied a previously developed mathematical model on importatio ... | 2016 | 28156871 |
| zika virus infection and wolbachia (comment on doi: 10.1002/bies.201600175). | | 2017 | 28156001 |
| zika virus induces inflammasome activation in the glial cell line u87-mg. | in the last years, neurological complications related to zika virus (zikv) infection have emerged as an important threat to public health worldwide. zikv infection has been associated to neurological disorders such as congenital microcephaly in newborns and guillain-barré syndrome, myelopathy and encephalitis in adults. zikv is characterized by neurotropism and neurovirulence. several studies have identified microglial nodules, gliosis, neuronal and glial cells degeneration and necrosis in the b ... | 2017 | 28153732 |
| infant outcomes among women with zika virus infection during pregnancy: results of a large prenatal zika screening program. | zika virus infection during pregnancy is a known cause of congenital microcephaly and other neurologic morbidities. | 2017 | 28153665 |
| study protocol on establishment of sentinel sites network for contraceptive and abortion trends, needs and utilization of services in zika virus affected countries. | zikv(zika virus) during pregnancy can result in many adverse events such as fetal deaths or newborns with congenital abnormalities including microcephaly and other neural irregularities. due to these harmful outcomes of pregnancy associated with the zika virus, we can expect to see a change in the type and scale of demand for family planning and safe abortion services in areas affected by the zika virus. the monitoring and reporting capacities of the local health clinics in these areas could ben ... | 2017 | 28153056 |
| a study protocol for facility assessment and follow-up evaluations of the barriers to access, availability, utilization and readiness of contraception, abortion and postabortion services in zika affected areas. | the zika virus epidemic in latin america has elicited official recommendations for women to delay or avoid pregnancy in affected countries, which has increased demand for family planning services. it is likely, however, that health facilities in areas where the population is most vulnerable to the disease lack the capacity to respond to the increased demand for family planning services. our objectives are to perform facilities assessment and understand client perceptions in areas affected by zik ... | 2017 | 28153043 |
| zika virus infection: what is the new problem? | | 2016 | 28152376 |
| zika virus protection by a single low-dose nucleoside-modified mrna vaccination. | zika virus (zikv) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. there are no zikv-specific treatments or preventatives. therefore, the development of a safe and effective vaccine is a high priority. messenger rna (mrna) has emerged as a versatile and highly effective platform to deliver vaccine antigens and therapeutic proteins. here we demonstrate that a single low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-mo ... | 2017 | 28151488 |
| zika virus infection, summer olympic and paralympic games in rio 2016, and sports performance. | | 2016 | 28149405 |
| animal models of zika virus infection, pathogenesis, and immunity. | zika virus (zikv) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. the virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with guillain-barré sy ... | 2017 | 28148798 |
| consequences of the zika outbreak in brazil. | the zika virus has been spreading in south america for almost a year. sophie and pierre are spending a month in recife, brazil, to help out at a local health organisation. | 2017 | 28148409 |
| [zika virus infection in pregnancy, fetal and neonatal impact]. | zika virus (zv) is an arbovirus transmitted by aedes aegypti and a. albopictus. the neurotropic profile of this virus is known since 1952. the main finding related to zv in america is microcephaly. two hypotheses are tested on its involvement in the central nervous system: its neurotropic feature and the direct effect of zv on the placenta. malformations and clinical findings on fetal development comprise congenital zika syndrome. rt-pcr and serology (igm) are useful for definitive diagnosis. ho ... | 2016 | 28146192 |
| investigating the potential role of north american animals as hosts for zika virus. | the recent emergence of the mosquito-borne zika virus (zikv) in the americas has become a global public health concern. we describe a series of experimental infections designed to investigate whether animals within certain taxonomic groups in north america have the potential to serve as zikv amplifying or maintenance hosts. species investigated included armadillos, cottontail rabbits, goats, mink, chickens, pigeons, ground hogs, deer mice, cattle, raccoons, ducks, syrian golden hamsters, garter ... | 2017 | 28145811 |
| zika, the olympics, and golden opportunities. | | 2017 | 28143801 |
| zika virus tissue and blood compartmentalization in acute infection of rhesus macaques. | animal models of zika virus (zikv) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. we inoculated 2 non-pregnant rhesus macaques with a 2015 brazilian zikv strain. consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias tha ... | 2017 | 28141843 |
| correction for caminade et al., global risk model for vector-borne transmission of zika virus reveals the role of el niño 2015. | | 2017 | 28137863 |
| challenges with mosquito-borne viral diseases: outbreak of the monsters. | the viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from south africa to asia, europe and united states. the current global scenario and recent documentations indicate towards the real monsters, outbreak of zika, dengue and chikungunya viruses. zika, dengue and chikungunya viruses, all three are positive sense single-stranded rna arbovirus and so their initial symptom ... | 2017 | 28137229 |
| prenatal imaging findings in fetal zika virus infection. | the aim of this review is to report the most recent observations concerning intrauterine zika virus (zikv) infection and associated neuroimaging. | 2017 | 28134669 |
| recent zika virus isolates induce premature differentiation of neural progenitors in human brain organoids. | the recent zika virus (zikv) epidemic is associated with microcephaly in newborns. although the connection between zikv and neurodevelopmental defects is widely recognized, the underlying mechanisms are poorly understood. here we show that two recently isolated strains of zikv, an american strain from an infected fetal brain (fb-gwuh-2016) and a closely-related asian strain (h/pf/2013), productively infect human ipsc-derived brain organoids. both of these strains readily target to and replicate ... | 2017 | 28132835 |
| zika virus causes testis damage and leads to male infertility in mice. | | 2017 | 28129543 |
| molecular and cellular insights into zika virus-related neuropathies. | zika virus (zikv), a relatively elusive aedes mosquito-transmitted flavivirus, had been brought into spotlight until recent widespread outbreaks accompanied by unexpectedly severe clinical neuropathies, including fetal microcephaly and guillain-barré syndrome (gbs) in the adult. in this review, we focus on the underlying cellular and molecular mechanisms by which vertically transmitted microorganisms reach the fetus and trigger neuropathies. | 2017 | 28127671 |
| future developments in biosensors for field-ready zika virus diagnostics. | since early reports of the recent zika virus outbreak in may 2015, much has been learned and discussed regarding zika virus infection and transmission. however, many opportunities still remain for translating these findings into field-ready sensors and diagnostics. in this brief review, we discuss current diagnostic methods, consider the prospects of translating other flavivirus biosensors directly to zika virus sensing, and look toward the future developments needed for high-sensitivity and hig ... | 2017 | 28127399 |
| comprehensive annotation of mature peptides and genotypes for zika virus. | the rapid spread of zika virus (zikv) has caused much concern in the global health community, due in part to a link to fetal microcephaly and other neurological illnesses. while an increasing amount of zikv genomic sequence data is being generated, an understanding of the virus molecular biology is still greatly lacking. a significant step towards establishing zikv proteomics would be the compilation of all proteins produced by the virus, and the resultant virus genotypes. here we report for the ... | 2017 | 28125631 |
| use of obstetric practice web sites to distribute zika virus information to pregnant women during a zika virus outbreak. | to describe the current use of obstetric practice web sites to disseminate zika virus information to patients. | 2017 | 28125540 |
| epidemic potential for local transmission of zika virus in 2015 and 2016 in queensland, australia. | zika virus could be transmitted in the state of queensland, australia, in parts of the state where the mosquito vectors are established. | 2016 | 28123859 |
| zika virus targeting in the developing brain. | zika virus (zikv), a positive-sense rna flavivirus, has attracted considerable attention recently for its potential to cause serious neurological problems, including microcephaly, cortical thinning, and blindness during early development. recent findings suggest that zikv infection of the brain can occur not only during very early stages of development, but also in later fetal/early neonatal stages of maturation. surprisingly, after peripheral inoculation of immunocompetent mice on the day of bi ... | 2017 | 28123079 |
| risk of travel-related cases of zika virus infection is predicted by transmission intensity in outbreak-affected countries. | zika virus (zikv) infection is emerging globally, currently causing outbreaks in the caribbean, and central and south america, and putting travellers to affected countries at risk. model-based estimates for the basic reproduction number (r 0 ) of zikv in affected caribbean and central and south american countries, obtained from 2015 to 2016 human case surveillance data, were compared by logistic regression and receiver-operating characteristic (roc), with the prevalence of zikv-positive test res ... | 2017 | 28122631 |
| the conformational changes of zika virus methyltransferase upon converting sam to sah. | an outbreak of zika virus (zikv) infection has been reported in south and central america and the caribbean. neonatal microcephaly potentially associated with zikv infection has already caused a public health emergency of international concern. currently, there are no clinically effective vaccines or antiviral drugs available to treat zikv infection. the methyltransferase domain (mtase) of zikv nonstructural protein 5 (ns5) can sequentially methylate guanine n-7 and ribose 2'-o to form m7ngpppa2 ... | 2017 | 28122329 |
| announcement: guidance for u.s. laboratory testing for zika virus infection: implications for health care providers. | | 2017 | 28122169 |
| more than half of women in brazil avoiding pregnancy due to zika virus. | experts have called for a review of the criminalisation of abortion and better access to contraception for women in brazil after research revealed more than 50% are avoiding getting pregnant because of the zika virus. | 2017 | 28120653 |
| the role of secretory autophagy in zika virus transfer through the placental barrier. | recent studies indicated that the zika virus genome could be detected in the amniotic fluid and the fetal brain, which confirms that the virus can cross the placental barrier. secretory autophagy or exosome pathways may participate in this virus transfer. autophagy modulators regulate autophagosome formation or membrane fusion with lysosomal vesicles and therefore inhibit viral nucleocapsid releasing or virus transfer to the fetus hypothetically. however, some autophagy modulators may enhance vi ... | 2016 | 28119857 |
| capillary fragility in zika virus infection. | | 2017 | 28117038 |
| zika virus infection and the olympic games 2016. | | 2017 | 28117035 |
| assessing sensitivity and specificity of surveillance case definitions for zika virus disease. | we evaluated performance of 5 case definitions for zika virus disease surveillance in a human cohort during an outbreak in singapore, august 26-september 5, 2016. because laboratory tests are largely inaccessible, use of case definitions that include rash as a required clinical feature are useful in identifying this disease. | 2017 | 28117032 |
| zika virus disrupts molecular fingerprinting of human neurospheres. | zika virus (zikv) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of zikv to human brain development are still not fully understood. here we describe alterations in human neurospheres derived from induced pluripotent stem (ips) cells infected with the strain of zika virus that is circulating in brazil. combining proteomics and mrna transcriptional profiling, over 500 proteins and genes associated with the brazilian zikv infection were foun ... | 2017 | 28112162 |
| fast preparation of a long chimeric armored rna as controls for external quality assessment for molecular detection of zika virus. | the emergence of zika virus demands accurate laboratory diagnostics. nucleic acid testing is currently the definitive method for diagnosis of zika infection. in 2016, an external quality assurance (eqa) for assessing the quality of molecular testing of zika virus was carried out in china. | 2017 | 28111270 |
| an integrated approach for the assessment of the aedes aegypti and aedes albopictus global spatial distribution, and determination of the zones susceptible to the development of zika virus. | the zika virus, one of the new epidemic diseases, is reported to have affected millions of people in the past year. the suitable climate conditions of the areas where zika virus has been reported, especially in areas with a high population density, are the main cause of the current outbreak and spread of the disease. indeed, the suitable climatic conditions of certain territories constitute perfect breading nest for the propagation and outbreak of worldwide diseases. the main objective of this r ... | 2017 | 28111132 |
| zika virus in the testes: should we be worried? | | 2017 | 28110372 |
| importation of zika virus in china: a significant risk in southern china. | | 2017 | 28109676 |
| zika virus infection-do they also endanger male fertility? | | 2017 | 28108947 |
| the impact of zika virus in the brain. | the recent outbreak of zikv in brazil called the attention of the world because the effects of viral infection in the brain under development in fetuses. consequences of vertical infection comprise brain malformation, especially microcephaly, eye and musculoskeletal abnormalities, among others. in adults, outcomes of infection include meningoencephalitis and guillain-barré syndrome. recent data specific suggest that neural progenitor cells are the main targets of zikv infection, causing massive ... | 2017 | 28108286 |
| zika virus from a southeast asian perspective. | phylogenic evidence suggests that the strain of zika virus causing an unprecedented outbreak of disease in the americas had its origin in southeast asia, where reports of isolated cases of zika virus infection have occurred since 2010. why there has been no large outbreak of zika infection in southeast asia remains unclear and whether such an outbreak will occur in the future is a question of significant concern. this review looks at zika virus from a southeast asian perspective and highlights s ... | 2017 | 28107856 |
| noteworthy literature published in 2016 for abdominal organ transplant anesthesiologists. | more than 400 peer-reviewed publications on the topic of pancreas transplantation, more than 400 on intestine transplantation, and more than 3000 on renal transplantation were published in 2016. this review will highlight the most pertinent literature for anesthesiologists caring for patients undergoing non-liver abdominal organ transplantation. this review is the second part in an annual series to review relevant contributions in the field of abdominal organ transplantation focusing on pancreas ... | 2017 | 28107792 |
| experimental transmission of zika virus by mosquitoes from central europe. | mosquitoes collected in germany in 2016, including culex pipiens pipiens biotype pipiens, culex torrentium and aedes albopictus, as well as culex pipiens pipiens biotype molestus (in colony since 2011) were experimentally infected with zika virus (zikv) at 18 °c or 27 °c. none of the culex taxa showed vector competence for zikv. in contrast, aedes albopictus were susceptible for zikv but only at 27 °c, with transmission rates similar to an aedes aegypti laboratory colony tested in parallel. | 2017 | 28106528 |