| identification of candidate proteins for the diagnosis of bartonella henselae infections using an immunoproteomic approach. | bartonella henselae is an emerging gram-negative facultative intracellular pathogen transmitted via ctenocephalides felis (cat fleas) or cat scratches. bartonellosis is present mainly in the form of cat scratch disease (csd), bacillary angiomatosis and infective endocarditis (ie). the methods used to diagnose b. henselae rely on culturing, immunofluorescent assays and molecular techniques. the objective of the present study was to identify candidate proteins for the serodiagnosis of bartonellosi ... | 2010 | 20695898 |
| human coinfection with bartonella henselae and two hemotropic mycoplasma variants resembling mycoplasma ovis. | two variants of an organism resembling the ovine hemoplasma, mycoplasma ovis, were detected by pcr in blood samples from a veterinarian in texas. coinfection with similar variants has been described in sheep. this represents the first report of human infection with this organism. the veterinarian was coinfected with bartonella henselae. | 2010 | 20702675 |
| real-time and multiplex real-time polymerase chain reactions for the detection of bartonella henselae within cat flea, ctenocephalides felis, samples. | bartonella henselae (rhizobiales: bartonellacae), the agent of cat-scratch disease, is an emerging bacterial pathogen which can be transmitted via infective faecal material of ctenocephalides felis bouché (siphonaptera: pulicidae). worldwide, b. henselae has been identified in 1-53% of felines and 2.9-17.4% of fleas. although culture is the routine method for detection, the procedure is time-consuming and is rarely used for isolation directly from flea vectors. the current study reports the deve ... | 2010 | 20704655 |
| neuralgic amyotrophy associated with bartonella henselae infection. | | 2011 | 20710009 |
| skin diseases associated with bartonella infection: facts and controversies. | the genus bartonella is composed of a series of species and subspecies. ten of them are responsible for human infections. the best-identified diseases are cat scratch disease (b henselae and possibly b clarridgeiae), trench fever (b quintana), bacillary angiomatosis (b quintana and b henselae), and the spectrum of verruga peruana, carrion disease, and oroya fever (b bacilliformis). controversies exist about the implication of a few other microorganisms being involved in these diseases. several o ... | 2010 | 20797506 |
| bartonella genotypes in fleas (insecta: siphonaptera) collected from rodents in the negev desert, israel. | fleas collected from rodents in the negev desert in southern israel were molecularly screened for bartonella species. a total of 1,148 fleas, collected from 122 rodents belonging to six species, were pooled in 245 pools based on flea species, sex, and rodent host species. two bartonella gene fragments, corresponding to rna polymerase b (rpob) and citrate synthase (glta), were targeted, and 94 and 74 flea pools were found positive by pcr, respectively. the bartonella 16s-23s internal transcribed ... | 2010 | 20802081 |
| bartonella species, feline herpesvirus-1, and toxoplasma gondii pcr assay results from blood and aqueous humor samples from 104 cats with naturally occurring endogenous uveitis. | toxoplasma gondii, bartonella henselae and feline herpesvirus-1 (fhv-1) have been implicated as causative agents in feline uveitis. the usefulness of serum and aqueous humor (ah) antibody testing for these agents is limited as antibodies can be detected in both healthy cats and cats with uveitis. very few studies using polymerase chain reaction (pcr) assays to amplify organism dna from samples from cats with uveitis have been performed. in this study, assays to detect t gondii antibodies, feline ... | 2010 | 20817587 |
| cat scratch disease and arthropod vectors: more to it than a scratch? | cat scratch disease is a common infection, particularly in children, and clinicians need to be aware of its potential transmission to humans by arthropod vectors such as fleas and ticks in addition to animal bites and scratches. the absence of a vertebrate bite or scratch does not preclude infection with bartonella henselae. | 2010 | 20823366 |
| [neuroretinitis in cat scratch disease]. | purpose: to present two cases of neuroretinitis in cat scratch disease we present two girls treated in department of ophthalmology of poznai university of medical sciences because of unilateral, painless decrease of vision. both patients presented following cat exposure fever and lymph nodes swelling. ophthalmoscopic findings was neuroretinitis (optic disc edema with the macular star). bartonella henselae antibody titers (igg) were elevated. csd is usually self-limited infection in immunocompete ... | 2010 | 20825068 |
| impairment of circulating endothelial progenitors in down syndrome. | pathological angiogenesis represents a critical issue in the progression of many diseases. down syndrome is postulated to be a systemic anti-angiogenesis disease model, possibly due to increased expression of anti-angiogenic regulators on chromosome 21. the aim of our study was to elucidate some features of circulating endothelial progenitor cells in the context of this syndrome. | 2010 | 20836844 |
| a first japanese case of bartonella henselae-induced endocarditis diagnosed by prolonged culture of a specimen from the excised valve. | bartonella henselae, the causative agent of cat scratch disease, is increasingly recognized as a cause of culture-negative endocarditis. this report describes the first japanese case, which was diagnosed after a prolonged culture of the excised aortic valve. high igg and igm titers to b. henselae pointed to a subacute course of the disease. | 2010 | 20846591 |
| combined mlst and aflp typing of bartonella henselae isolated from cats reveals new sequence types and suggests clonal evolution. | bartonella species are gram-negative, fastidious bacteria. bartonella henselae is found in cats and transmitted to humans via cat scratches or bites causing cat-scratch disease, characterized by clinical symptoms with varying severity. the prevalence of bartonellosis among humans in germany appears to be high, and severe clinical cases have been described. however, epidemiological data of b. henselae in cats are rare. in this study we determined the detection rates of bartonella ssp. in cats by ... | 2010 | 20863631 |
| rats as indicators of the presence and dispersal of six zoonotic microbial agents in cyprus, an island ecosystem: a seroepidemiological study. | a total of 622 rats (402 rattus norvegicus and 220 r. rattus frugivorus) were collected in 51 different areas in cyprus during 2000-2003 and used as indicators of the presence and dispersal of six zoonotic microbial agents. igg antibodies against rickettsia typhi (241/496, 48.6%), r. conorii (209/500, 41.8%), toxoplasma sp. (138/494, 27.9%), coxiella burnetti (63/494, 12.8%), bartonella henselae (52/494, 10.5%) and leishmania infantum (36/494, 7.3%) were detected by indirect immunofluorescence t ... | 2010 | 20870259 |
| feline bartonellosis. | bartonella infection is common among domestic cats, but the role of bartonella species as feline pathogens requires further study. most bartonella species that infect cats are zoonotic. cats are the mammalian reservoir and vector for bartonella henselae, an important zoonotic agent. cat fleas transmit bartonella among cats, and cats with fleas are an important source of human b henselae infections. new information about bartonella as feline pathogens has recently been published, and this article ... | 2010 | 20933137 |
| [cat-scratch disease]. | | 2010 | 20942049 |
| refractory bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia. | bacillary angiomatosis is a well-recognized infection with cutaneous and systemic manifestations caused by bartonella henselae or bartonella quintana and occurs in immunocompromised patients. we report a case of b. quintana bacillary angiomatosis following fludarabine-based chemotherapy for chronic lymphocytic leukaemia that was refractory to standard treatment and was complicated by lymphadenopathy and osteomyelitis. | 2010 | 20947664 |
| combined action of the type iv secretion effector proteins bepc and bepf promotes invasome formation of bartonella henselae on endothelial and epithelial cells. | bartonella henselae (bhe) can invade human endothelial cells (ecs) by two distinguishable entry routes: either individually by endocytosis or as large bacterial aggregates by invasome-mediated internalization. only the latter process is dependent on a functional virb/vird4 type iv secretion system (t4ss) and the thereby translocated bep effector proteins. here, we introduce hela cells as a new cell system suitable to study invasome formation. we describe a novel route to trigger invasome formati ... | 2010 | 20964799 |
| bartonella henselae and the potential for arthropod vector-borne transmission. | abstract introduction: bartonella henselae, the causative agent of the illness referred to as cat scratch disease, is a common infection, particularly in children, and clinicians need to be aware of its potential transmission to humans by arthropod vectors such as fleas and ticks in addition to animal bites and scratches. the absence of a vertebrate bite or scratch does not preclude infection with b. henselae. materials and methods: literature regarding arthropod transmission of b. henselae was ... | 2010 | 20973657 |
| occlusive vasculitis and optic disk neovascularization associated with neuroretinitis. | to report a case of neuroretinitis associated with ischemic nasal branch retinal vein occlusion, periphlebitis, and neovascularization of the optic disk. | 2010 | 21034304 |
| a comparative study of the interaction of bartonella henselae strains with human endothelial cells. | bartonella henselae can cause a wide range of clinical outcomes and may lead to severe disease, especially in patients with acquired immunodeficiency syndrome. it is well-known that b. henselae-induced cell proliferation is mediated by anti-apoptotic activity; however, the detailed mechanism is still unclear. in this study, the cellular responses of endothelial cells after infection with four b. henselae strains were compared and protein candidates that may be involved in the interaction between ... | 2010 | 21035278 |
| relevance of feline calicivirus, feline immunodeficiency virus, feline leukemia virus, feline herpesvirus and bartonella henselae in cats with chronic gingivostomatitis. | despite its common occurrence, the aetiology of chronic gingivostomatitis in cats remains uncertain. aetiology is likely multifactorial, and several infectious agents may be associated with chronic gingivostomatitis. the purpose of this study was to investigate the prevalence of feline calicivirus (fcv), feline immunodeficiency virus (fiv), feline leukemia virus (felv), feline herpesvirus (fhv), and bartonella henselae (b. henselae) in cats with chronic gingivostomatitis and in an age-matched co ... | 2010 | 21038808 |
| the bartonella henselae virb/bep system interferes with vascular endothelial growth factor (vegf) signalling in human vascular endothelial cells. | the vasculotropic pathogen bartonella henselae (bh) intimately interacts with human endothelial cells (ecs) and subverts multiple cellular functions. here we report that bh specifically interferes with vascular endothelial growth factor (vegf) signalling in ecs. bh infection abrogated vegf-induced proliferation and wound closure of ec monolayers as well as the capillary-like sprouting of ec spheroids. on the molecular level, bh infection did not alter vegf receptor 2 (vegfr2) expression or cell ... | 2010 | 21044238 |
| [fever of unknown origin and detection of bartonella henselae igg seropositivity: a case report.] | bartonella henselae, is a gram-negative bacterium which causes cat scratch disease (csd) in man. there are sporadic case reports of csd in turkey. cats play an important reservoir role for b.henselae transmission to man. in this report, a cat owner with fever of unknown origin was presented. bartonella spp. was isolated from the blood culture of cat which had chronic progressive gingivostomatitis. b.henselae was identified by amplification of a region of citrate synthase (glta) gene by using pol ... | 2010 | 21064000 |
| prevalence of bartonella species dna and antibodies in cats (felis catus) submitted to a spay/neuter program in rio de janeiro, brazil. | the prevalence of bartonella species dna and antibodies for bartonella henselae were studied in 40 clinically healthy cats (felis catus, linnaeus 1758) submitted to a spay/neuter program in rio de janeiro, brazil. additionally, the prevalence of bartonella species dna was investigated in the fleas found parasitizing the subject cats. for this purpose, blood samples were obtained from all cats, and dna extraction was performed on the blood, and blood clotted samples, as well as on pools of fleas ... | 2010 | 21071251 |
| cat-scratch uveitis confirmed by histological, serological, and molecular diagnoses. | to report a case of a cat-scratch uveitis caused by bartonella henselae, which was confirmed by histology, serology, and polymerase chain reaction (pcr) methodology. | 2011 | 21099401 |
| prevalence of bartonella henselae and bartonella clarridgeiae in cats in the south of brazil: a molecular study. | bartonella spp are the causative agent of cat scratch disease in humans. cats are the natural reservoir of these bacteria and may infect humans through scratches, bites or fleas. blood samples from 47 cats aged up to 12 months were collected for this study. all animals were lodged in municipal animal shelters in the vale do sinos region, rio grande do sul, brazil. bartonella spp were detected by genus-specific polymerase chain reaction (pcr) and when the pcr was positive, the species were determ ... | 2010 | 21120356 |
| bartonella henselae in skin biopsy specimens of patients with cat-scratch disease. | during the past 2 years, we identified live bartonella henselae in the primary inoculation sites of 3 patients after a cat scratch. although our data are preliminary, we report that a cutaneous swab of the skin lesion from a patient in the early stage of cat-scratch disease can be useful for diagnosis of the infection. | 2010 | 21122232 |
| multispacer typing of bartonella henselae isolates from humans and cats, japan. | to determine genotypic distribution of and relationship between human and cat strains of bartonella henselae,we characterized 56 specimens using multispacer typing (mst). of 13 mst genotypes identified, 12 were grouped into cluster 1. in japan, human infections can be caused by b. henselae strains in cluster 1. | 2010 | 21122238 |
| bartonella infection in shelter cats and dogs and their ectoparasites. | abstract mainly through vector transmission, domestic cats and dogs are infected by several bartonella spp. and represent a large reservoir for human infections. this study investigated the relationship of prevalences of bartonella infection in shelter dogs and cats and various ectoparasite species infesting them (fleas, ticks, and lice). moreover, relationships between bartonella infection and animal gender and age and presence of ectoparasites were analyzed. blood samples were collected from 1 ... | 2010 | 21142966 |
| [vasoproliferative retinal tumours]. | vasoproliferative retinal tumors are benign tumors of unknown origin often accompanied by vitreoretinal inflammation. a 21-year-old female patient presented with acute reduced unilateral visual acuity. a solid yellow vascularized lesion was present in the inferior temporal retina accompanied by localized retinal detachment and accumulation of hard exudations. the only finding was an increased bartonella henselae titer. persistence of uveitis and blurred vision led to therapy for bartonella hense ... | 2011 | 21153829 |
| comparison of two sampling methods for microbiological evaluation of periodontal disease in cats. | periodontal disease in cats is highly prevalent, and its aetiology is associated to bacteria located in the subgingival microbiota, being porphyromonas sp. the most prevalent genus. the conventional technique to sample the subgingival microbiota is the use of cotton swabs over the mucosa and teeth; however the use of subgingival paper points could improve the bacterial recovery. | 2010 | 21168288 |
| [cat scratch disease associated neuroretinitis: clinical report and review of the literature]. | cat scratch disease is the main clinical presentation of bartonella henselae infection. however, ocular manifestations of bartonellosis occur in about 5 to 10% of the patients, mainly presenting as neuroretinitis, choroiditis or oculoglandular syndrome of parinaud. we describe two patients with documented b. henselae infection and typical ocular compromise. both patients were treated and had a favorable visual outcome. | 2010 | 21186508 |
| fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type iv secretion system effector bepa. | numerous bacterial pathogens subvert cellular functions of eukaryotic host cells by the injection of effector proteins via dedicated secretion systems. the type iv secretion system (t4ss) effector protein bepa from bartonella henselae is composed of an n-terminal fic domain and a c-terminal bartonella intracellular delivery domain, the latter being responsible for t4ss-mediated translocation into host cells. a proteolysis resistant fragment (residues 10-302) that includes the fic domain shows au ... | 2011 | 21213248 |
| suspecting optic neuritis, diagnosing bartonella cat scratch disease. | bartonella cat scratch disease is classically a febrile illness, in conjunction with lymphadenopathy and cat exposure. | 2011 | 21220684 |
| cat-scratch disease. | cat-scratch disease is a common infection that usually presents as tender lymphadenopathy. it should be included in the differential diagnosis of fever of unknown origin and any lymphadenopathy syndrome. asymptomatic, bacteremic cats with bartonella henselae in their saliva serve as vectors by biting and clawing the skin. cat fleas are responsible for horizontal transmission of the disease from cat to cat, and on occasion, arthropod vectors (fleas or ticks) may transmit the disease to humans. ca ... | 2011 | 21243990 |
| unusual retinal manifestations of cat scratch disease. | we report on 2 patients with unusual retinal manifestations of cat scratch disease (csd), caused by bartonella henselae. case 1. a 42-year-old farmer presented with a 5-day history of blurred vision in his right eye. right visual acuity was 20/25. fundus examination of the right eye revealed mild vitreous hemorrhage and diffuse retinal hemorrhages in the mid-peripheral retina. fluorescein angiography showed multiple vasculitic occlusions in the same area. a blood sample taken on the day of exami ... | 2011 | 21267628 |
| optic neuropathy secondary to cat scratch disease: case report. | optic neuropathy due to cat scratch disease is a relatively infrequent occurrence associated with macular star formation and is characterized by sudden painless loss of vision mostly unilateral. bartonella henselae is well recognized as the etiologic agent in cat scratch disease. ocular complications of the disease occur in up to 10% of patients and include neuroretinitis. ocular bartonelosis is usually self-limited with complete or near-complete recovery of vision in otherwise healthy patients. ... | 2010 | 21271032 |
| molecular detection of bartonella henselae for the diagnosis of cat scratch disease and bacillary angiomatosis of the conjunctiva. | the purpose of this study was to evaluate clinical cases of cat scratch disease (csd) and bacillary angiomatosis involving the conjunctiva by special stains and transmission electron microscopy (tem) and to compare these findings with the results from species-specific polymerase chain reaction (pcr) analysis of the same specimens. | 2011 | 21282991 |
| rickettsia felis and bartonella henselae in fleas from lebanon. | a total of 155 fleas collected in 2009 in lebanon from 16 cats (104 ctenocephalides felis specimens, 1 c. canis specimen) and 2 dogs (50 c. canis specimens) were tested for the presence of rickettsia spp. and bartonella spp. using molecular methods, including real-time quantitative polymerase chain reaction (pcr), regular pcr, and sequencing of amplified pcr products. rickettsia felis, the agent of the emerging flea-borne spotted fever in humans, was identified in 17 (16%) c. felis cat fleas. ba ... | 2011 | 21284512 |
| bacillary angiomatosis in an immunocompetent child: a case report and review of the literature. | bacillary angiomatosis is an infectious disease caused by 2 gram-negative bacilli, bartonella henselae and bartonella quintana. this disease is characterized by vascular proliferations in the skin and/or visceral organs, and typically manifests in immunocompromised patients. however, we report a case of a 10-year-old immunocompetent female child with a questionable history of being scratched by a cat. although initially diagnosed as a pyogenic granuloma, a diagnosis of bacillary angiomatosis was ... | 2011 | 21285862 |
| combining cytomorphology and serology for the diagnosis of cat scratch disease. | cat scratch disease (csd) is a self limited zoonotic disease that presents most commonly as a regional lymphadenopathy. we are reporting a case of a 25-year-old male patient who presented with fever and large right inguinal lymphadenopathy. the diagnosis of cat scratch disease was confirmed based on the characteristic cytopathological features on aspirate smears from the lymph node and the serological titers for bartonella henselae. this case report emphasizes the importance of combining bartone ... | 2011 | 21319324 |
| identification of bartonella henselae in a horse from germany. | | 2011 | 21388754 |
| challenges in the clinical management of blood-culture negative endocarditis: case of bartonella henselae infection. | | 2011 | 21396492 |
| bartonella henselae endocarditis of percutaneously implanted pulmonary valve: a case report. | percutaneous pulmonary valve implantation (ppvi) has revolutionized the management of right ventricular outflow tract dysfunction after repaired congenital heart disease. the technology is considered to be safe, with a relatively low complication rate. infection is one of the described complications of ppvi, and to date five cases of culture-positive infective endocarditis of percutaneously implanted pulmonary valve have been reported worldwide. herein is reported the first ever case of culture- ... | 2011 | 21404904 |
| 18f-fluoro-2-deoxyglucose positron emission tomography-negative endocarditis lenta caused by bartonella henselae. | it has been suggested that 18f-fluorodeoxyglucose positron emission tomography (fdg-pet) might serve as a tool for the often difficult diagnosis of infective endocarditis. the case is described of a patient with a bartonella henselae endocarditis with a negative fdg-pet. this case report demonstrates that negative fdg-pet findings do not rule out the presence of endocarditis. | 2011 | 21404906 |
| eschar and neck lymphadenopathy caused by francisella tularensis after a tick bite: a case report. | | 2011 | 21418587 |
| [sero-epidemiological investigation on rickettsia typhi, bartonella henselae and orientia tsutsugamushi in farmers from rural areas of tianjin, 2007 - 2009.] | objective: to study the sero-epidemiological status regarding rickettsia (r.) typhi, bartonella (b.) henselae and orientia (o.) tsutsugamushi in farmers from rural areas of tianjin. methods: field epidemiological surveys were performed in 8 districts (county) of tianjin city from 2007 to 2009. 886 farmers were randomly recruited and their serum samples collected to detect the specific antibodies of r. typhi, b. henselae and o. tsutsugamushi by micro-indirect immunoflorescence (ifa). results: the ... | 2011 | 21457660 |
| seasonality of cat-scratch disease, france, 1999-2009. | cat-scratch disease is seasonal in the united states and japan; but no data are available from europe. to assess the seasonality of the disease in france, we analyzed lymph node biopsy specimens collected during 1999-2009. most (87.5%) cases occurred during september-april and peaked in december. | 2011 | 21470466 |
| multilocus sequence typing of bartonella henselae in the united kingdom indicates that only a few, uncommon sequence types are associated with zoonotic disease. | bartonella henselae is one of the most common zoonotic agents acquired from companion animals (cats) in industrialized countries. nonetheless, although the prevalence of infections in cats is high, the number of human cases reported is relatively low. one hypothesis for this discrepancy is that b. henselae strains vary in their zoonotic potential. to test this hypothesis, we employed structured sampling to explore the population structure of b. henselae in the united kingdom and to determine the ... | 2011 | 21471345 |
| prevalence of rickettsia felis and the first identification of bartonella henselae fizz/cal-1 in cat fleas (siphonaptera: pulicidae) from taiwan. | cat fleas (ctenocephalides felis [bouché]) are the primary ectoparasites of dog and cat populations. in this study, we report the monthly population dynamics of rickettsia felis and bartonella spp. (two zoonotic pathogens that can cause human disease) in cat fleas collected from dogs and cats in taipei, taiwan, from december 2006 to december 2007. natural r. felis infection in individual cat fleas was assessed by polymerase chain reaction (pcr) using prf-, ompb-, and glta-specific primer pairs. ... | 2011 | 21485388 |
| adhesion and host cell modulation: critical pathogenicity determinants of bartonella henselae. | abstract: bartonella henselae, the agent of cat scratch disease and the vasculoproliferative disorders bacillary angiomatosis and peliosis hepatis, contains to date two groups of described pathogenicity factors: adhesins and type iv secretion systems. bartonella adhesin a (bada), the trw system and possibly filamentous hemagglutinin act as promiscous or specific adhesins, whereas the virulence locus (vir)b/vird4 type iv secretion system modulates a variety of host cell functions. bada mediates b ... | 2011 | 21489243 |
| identification of bartonella henselae in 2 cats with pyogranulomatous myocarditis and diaphragmatic myositis. | most cats infected with bartonella henselae remain outwardly healthy carriers for years; however, self-limiting fever, transient anemia, neurologic dysfunction, lymphadenopathy, reproductive disorders, aortic valvular endocarditis, and neutrophilic myocarditis have been described in experimentally or naturally infected cats. two cats in a north carolina shelter died with pyogranulomatous myocarditis and diaphragmatic myositis. bacteria were visualized in the lesions by warthin-starry silver impr ... | 2011 | 21490304 |
| absence of zoonotic bartonella species in questing ticks: first detection of bartonella clarridgeiae and rickettsia felis in cat fleas in the netherlands. | abstract: | 2011 | 21501464 |
| bone pain and fever in an adolescent and his sibling. cat scratch disease (csd). | | 2011 | 21513084 |
| bartonella spp. in feral pigs, southeastern united states. | in conjunction with efforts to assess pathogen exposure in feral pigs from the southeastern united states, we amplified bartonella henselae, b. koehlerae, and b. vinsonii subsp. berkhoffii from blood samples. feral pigs may represent a zoonotic risk for hunters or butchers and pose a potential threat to domesticated livestock. | 2011 | 21529405 |
| trimeric autotransporter adhesin-dependent adherence of bartonella henselae, bartonella quintana and yersinia enterocolitica to matrix components and endothelial cells under static and dynamic flow conditions. | trimeric autotransporter adhesins (taas) are important virulence factors of gram-negative bacteria responsible for adherence to extracellular matrix (ecm) and host cells. here, we analyzed three different taas [bartonella adhesin a (bada) of bartonella henselae, variably expressed outer membrane proteins (vomps) of bartonella quintana, yersinia adhesin a (yada) of yersinia enterocolitica] for mediating bacterial adherence to ecm and endothelial cells. using static (cell culture vials) and dynami ... | 2011 | 21536788 |
| bartonella spp. dna in cardiac tissues from dogs in colorado and wyoming. | background: several bartonella species (spp.) have been identified in dogs diagnosed with infectious endocarditis (ie) or myocarditis. objective: to interrogate cardiac tissues of dogs with suspected ie for the presence of bartonella spp. dna of dogs in the rocky mountain states. animals: nine dogs with a clinical diagnosis of endocarditis from january 1990 to june 2008 were included. methods: in this retrospective study, medical records at the veterinary teaching hospital were searched. animals ... | 2011 | 21539606 |
| thoracic vertebral osteomyelitis with paraspinous mass and intraspinal extension: an atypical presentation of cat-scratch disease. | children with cat-scratch disease (csd) commonly present with fever and tender lymphadenopathy. the disease is mild and manifestations of infection resolve spontaneously within several weeks. however, some children with csd have unusual features that present diagnostic challenges. children with atypical csd may present with prolonged fever, hepatosplenic disease or ocular disease. we performed an mri on a child who presented with persistent back pain. the mri demonstrated a paravertebral mass wi ... | 2011 | 21594549 |
| rickettsia, ehrlichia, anaplasma, and bartonella in ticks and fleas from dogs and cats in bangkok. | abstract flea and tick specimens (5-10 fleas or ticks) on dogs and cats from various sites in bangkok were tested by polymerase chain reaction and dna sequencing to detect dna of bacteria rickettsia (glta and 17 kda genes), anaplasmataceae (16s rrna gene), and bartonella (pap31 and its genes). we confirmed that rickettsia sp. related to rickettsia felis was detected in 66 of 98 (67.4%) flea specimens from dogs, whereas 8 bartonella henselae and 2 bartonella clarridgeiae were detected in 10 of 54 ... | 2011 | 21612535 |
| molecular and serological diagnosis of bartonella infection in 61 dogs from the united states. | background: molecular diagnosis of canine bartonellosis can be extremely challenging and often requires the use of an enrichment culture approach followed by pcr amplification of bacterial dna. hypotheses: (1) the use of enrichment culture with pcr will increase molecular detection of bacteremia and will expand the diversity of bartonella species detected. (2) serological testing for bartonella henselae and bartonella vinsonii subsp. berkhoffii does not correlate with documentation of bacteremia ... | 2011 | 21615498 |
| systemic bartonella henselae infection in immunocompetent adult presenting as fever of unknown origin. | systemic clinical presentations of infection caused by bartonella henselae are rare in immunocompetent adults. we report four cases with hepatic and/or splenic involvement, presenting as fever of unknown origin. we discuss diagnosis and treatment of this infection. bartonella henselae serology allows an easy diagnosis of hepatosplenic involvement in cat scratch disease, a clinical picture that appears to be underrecognized. | 2011 | 21629850 |
| differential effects of bartonella henselae on human and feline macro- and micro-vascular endothelial cells. | bartonella henselae, a zoonotic agent, induces tumors of endothelial cells (ecs), namely bacillary angiomatosis and peliosis in immunosuppressed humans but not in cats. in vitro studies on ecs represent to date the only way to explore the interactions between bartonella henselae and vascular endothelium. however, no comparative study of the interactions between bartonella henselae and human (incidental host) ecs vs feline (reservoir host) ecs has been carried out because of the absence of any av ... | 2011 | 21637717 |
| investigation of anaplasmosis in yiyuan county, shandong province, china. | to investigate the situation of anaplasmosis in yiyuan county, shandong province. | 2011 | 21803311 |
| optic neuropathy and cat scratch disease. | | 2011 | 21779676 |
| human seroreactivity against bartonella species in the democratic republic of congo. | to assess the presence and identity of bartonella species in a pool of human blood samples from drc congo. | 2011 | 21771478 |
| fleas as parasites of the family canidae. | abstract: historically, flea-borne diseases are among the most important medical diseases of humans. plague and murine typhus are known for centuries while the last years brought some new flea-transmitted pathogens, like r. felis and bartonella henselae. dogs may play an essential or an accidental role in the natural transmission cycle of flea-borne pathogens. they support the growth of some of the pathogens or they serve as transport vehicles for infected fleas between their natural reservoirs ... | 2011 | 21767354 |
| an acpxl mutant in rhizobium leguminosarum bv. phaseolus lacks 27-hydroxyoctacosanoic acid in its lipid a and is developmentally delayed during symbiotic infection of the determinate nodulating host plant phaseolus vulgaris. | rhizobium leguminosarum is a gram negative bacterium that forms nitrogen fixing symbioses with compatible leguminous plants via intracellular invasion and establishes a persistent infection within host membrane derived subcellular compartments. notably, an unusual very long chain fatty acid (vlcfa) is found in the lipid a of r. leguminosarum as well as in the lipid a of the medically relevant pathogens brucella abortus, brucella melitensis, bartonella henselae, and legionellae pneumophila which ... | 2011 | 21764936 |
| bartonella and intraocular inflammation: a series of cases and review of literature. | to present various forms of uveitis and/or retinal vasculitis attributed to bartonella infection and review the impact of this microorganism in patients with uveitis. | 2011 | 21750616 |
| bartonella henselae infection of prosthetic aortic valve associated with colitis. | abstract the diagnosis of infective endocarditis can be difficult, particularly with atypical presentation and negative blood cultures. a 61-year-old man with a porcine aortic valve presented with fever, intermittent confusion, diarrhea, and fatigue. in the community clinic setting, a colonoscopy performed for anemia demonstrated colitis. symptoms progressed for months; elicitation of a history of significant kitten exposure and the finding of an axillary lymph node prompted testing for bartonel ... | 2011 | 21702667 |
| vertebral osteomyelitis: an unusual presentation of bartonella henselae infection. | objectives: to report cases of cat scratch disease with vertebral osteomyelitis. methods: we describe clinical features, diagnostic, treatment, and outcome of 2 patients with vertebral osteomyelitis due to bartonella henselae and provide a review of the relevant literature. results: a 47-year-old man was investigated for fever, splenomegaly, and cervical adenopathy. a lymphoma was suspected on the clinical picture, the laboratory tests, and the computed tomographic scan. [(18)f]-fluoro-2-deoxy-d ... | 2011 | 21840042 |
| molecular identification of bartonella quintana infection using species-specific real-time pcr targeting transcriptional regulatory protein (bqtr) gene. | we describe a sybr green i-based real-time pcr targeting bartonella quintana transcriptional regulatory protein (bqtr) gene, recently found as invariant gene among different b.quintana strains. melting curve analysis allowed us to discriminate between b.quintana and bartonella henselae amplified products. we also show its usefulness in the management of a blood culture-negative patient affected by enlarged cervical lymphonodes and long-lasting fever. b.quintana dna detection in patient whole blo ... | 2011 | 21816218 |
| occurrence of bartonella henselae types i and ii in central italian domestic cats. | serological and molecular surveys were conducted to determine the occurrence of bartonella henselae in domestic cats in central italy. samples from 234 pet cats were tested for b. henselae antibodies by indirect immunofluorescence with 78 (33.3%) positive. a pcr assay specific for the bartonella 16s rrna gene was carried out on dna samples extracted from blood of the 234 cats; 26 (11.1%) of the seropositive cats were positive. two pcr protocols, which discriminate genotypes i and ii of b. hensel ... | 2011 | 21824634 |
| occurrence of bartonella henselae and borrelia burgdorferi sensu lato co-infections in ticks collected from humans in germany. | bartonella (b.) henselae is the zoonotic agent of cat scratch disease. b. henselae has been associated with therapy-resistant lyme disease in humans suggesting that b. henselae and borrelia burgdorferi sensu lato might be transmitted concurrently by ticks. in the present study we found that 16 (6.9%) of 230 ixodes ricinus collected from humans harboured dna of bartonella spp. fifteen positive ticks were infected with b. henselae and one tick with b. clarridgeiae. twenty-five percent of the 16 ba ... | 2011 | 21682805 |
| ecological diversity of bartonella species infection among dogs and their owner in virginia. | abstract bartonella species comprise a genus of gram-negative, fastidious, intracellular bacteria that have been implicated in association with an increasing spectrum of disease manifestations in dogs and human patients. in this study, chronic canine and human disease, for which causation was not diagnostically defined, were reported by the breeder of a kennel of doberman pinschers. in addition to other diagnostic tests, serology, polymerase chain reaction, and enrichment blood culture were used ... | 2011 | 21736485 |
| conjugative dna transfer into human cells by the virb/vird4 type iv secretion system of the bacterial pathogen bartonella henselae. | bacterial type iv secretion systems (t4ss) mediate interbacterial conjugative dna transfer and transkingdom protein transfer into eukaryotic host cells in bacterial pathogenesis. the sole bacterium known to naturally transfer dna into eukaryotic host cells via a t4ss is the plant pathogen agrobacterium tumefaciens. here we demonstrate t4ss-mediated dna transfer from a human bacterial pathogen into human cells. we show that the zoonotic pathogen bartonella henselae can transfer a cryptic plasmid ... | 2011 | 21844337 |
| bilateral bartonella henselae neuroretinitis with stellate maculopathy in a 6-year-old boy. | purpose: bartonella henselae, the cause of cat-scratch disease in humans, may lead to characteristic vision-threatening ocular findings, which importantly indicate diagnosis. methods: this is an observational case report of a 6-year-old boy who presented with bilateral stellate maculopathy and lymphadenopathy. results: after serologic verification of b. henselae infection, systemic azithromycin therapy initiated the full recovery of visual acuity and bilateral complete resolution of stellate exu ... | 2011 | 21826435 |
| bartonella endocarditis complicating congenital heart disease. | the present report describes a case of bartonella henselae endocarditis affecting an adolescent with congenital heart disease. a teenager from eastern europe was referred to for surgical treatment of aortic endocarditis. she admitted close contact with cats. blood culture was negative. diagnosis of b henselae was established on direct pcr amplification and 16srrna gene sequencing of the aortic valve tissue and confirmed after 4 weeks by valve culture isolate. the patient underwent extended root ... | 2009 | 21686936 |
| a serological investigation of bartonella henselae infection in cats in turkey. | bartonella henselae is the causative agent of cat scratch disease (csd) in humans. cats are the main reservoir of this bacterium and may infect humans through scratches and bites. the purpose of this study was to determine the b. henselae seroprevalence in cats in turkey. a total of 298 cats blood samples were collected from six different provinces of turkey. sera were tested for the presence of anti-b. henselae igg antibodies by indirect fluorescent antibody test (ifa). the seroprevalence of b. ... | 2011 | 21737965 |
| molecular detection of rickettsia felis, bartonella henselae, and b. clarridgeiae in fleas from domestic dogs and cats in malaysia. | the presence of rickettsia felis, bartonella henselae and b. clarridgeiae in 209 fleas (ctenocephalides felis) obtained from domestic cats and dogs in several locations in malaysia was investigated in this study. using a polymerase chain reaction specific for the citrate synthase (glta) and 17-kd antigenic protein (17kd) genes of rickettsiae, we detected r. felis dna in 6 (2.9%) fleas. for detection of bartonellae, amplification of the heme-binding protein (pap31) and riboflavin synthase (ribc) ... | 2011 | 22049052 |
| gammopathy in a spanish dog infected with bartonella henselae. | generalised pyogranulomatous disease and hyperviscosity syndrome associated with a presumed monoclonal gammopathy was diagnosed in a three-year-old intact female pomeranian. the bartonella henselae antibody titer was 1:64 and bartonella species dna was amplified from the splenic tissue. monoclonal gammopathies in dogs are typically associated with plasma cell and lymphoid dyscrasias and other inflammatory or infectious diseases such as ehrlichiosis and leishmaniosis. based on this case report, i ... | 2011 | 21906064 |
| bartonella infective endocarditis of a prosthetic aortic valve with a subvalvular abscess. | a patient with a prosthetic aortic valve, and culture negative endocarditis caused by bartonella henselae presented with nonspecific constitutional symptoms, skin rash, and then later developed acute renal failure. the patient underwent redo sternotomy, aortic root, and ascending aorta replacement with a homograft, which resolved his symptoms and the renal failure. | 2011 | 21848606 |
| structure of fructose bisphosphate aldolase from bartonella henselae bound to fructose 1,6-bisphosphate. | fructose bisphosphate aldolase (fbpa) enzymes have been found in a broad range of eukaryotic and prokaryotic organisms. fbpa catalyses the cleavage of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. the ssgcid has reported several fbpa structures from pathogenic sources, including the bacterium brucella melitensis and the protozoan babesia bovis. bioinformatic analysis of the bartonella henselae genome revealed an fbpa homolog. the b. henselae fbpa enzym ... | 2011 | 21904049 |
| Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis. | Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. | 2011 | 22032579 |
| bartonella species bacteremia in two patients with epithelioid hemangioendothelioma. | bartonella henselae and b. koehlerae bacteremia was documented in two epithelioid hemangioendothelioma patients and b. koehlerae bacteremia in an asymptomatic partner of one of the patients. considering the biology and clinically variable natural history of epithelioid hemangioendothelioma, these results suggest that chronic bartonella infection could have a role in the development of this vascular neoplasm. bartonella spp. are known to induce vasoproliferative tumors in immunocompromised patien ... | 2011 | 21918021 |
| Inhibition of fibroblast apoptosis by Borrelia afzelii, Coxiella burnetii and Bartonella henselae. | Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The aim of this study was to investigate the influence of Borrelia afzelii, Coxiella burnetii, and Bartonella henselae bacteria on apoptosis measured as the level of caspase 3 activity in human fibroblast cells HEL-299. Our findings show that C. burnetii bacteria may inhibit the process of apoptosis in the host cells for a long time. This can permit intracellular survival in the host a ... | 2011 | 22184936 |
| systemic bartonella henselae infection and crohn's disease treatment with infliximab. | | 2012 | 21928372 |
| analysis of the bada stalk from bartonella henselae reveals domain-specific and domain-overlapping functions in the host cell infection process. | human pathogenic bartonella henselae cause cat scratch disease and vasculoproliferative disorders. an important pathogenicity factor of b. henselae is the trimeric autotransporter adhesin bartonella adhesin a (bada) which is modularly constructed and consists of a head, a long and repetitive neck-stalk module with 22 repetitive neck/stalk repeats and a membrane anchor. the bada head is crucial for bacterial adherence to host cells, binding to several extracellular matrix proteins and for the ind ... | 2011 | 21981119 |
| bacteriological and molecular identification of bartonella species in cats from different regions of china. | with the improvements in diagnostic techniques, bartonella henselae (b. henselae) infection has recently been recognized to cause a widening spectrum of diseases. cats are the natural reservoir hosts of b. henselae. the current study aims to investigate the prevalence of b. henselae infection in the cat populations in china. polymerase chain reaction (pcr) and bacterial cultures confirm that 12.7% of the tested cats were positive for the infection. old age and outdoor exposure were statistically ... | 2011 | 21909443 |
| bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. | the virb/d4 type iv secretion system (t4ss) of the bacterial pathogen bartonella henselae (bhe) translocates seven effector proteins (bepa-bepg) into human cells that subvert host cellular functions. two redundant pathways dependent on bepg or the combination of bepc and bepf trigger the formation of a bacterial uptake structure termed the invasome. invasome formation is a multi-step process consisting of bacterial adherence, effector translocation, aggregation of bacteria on the cell surface an ... | 2011 | 22045736 |
| zoonotic bartonella species in fleas and blood from red foxes in australia. | abstract bartonella are arthropod-borne, fastidious, gram-negative, and aerobic bacilli distributed by fleas, lice, sand flies, and, possibly, ticks. the zoonotic bartonella species, bartonella henselae and bartonella clarridgeiae, which are the causes of cat scratch disease and endocarditis in humans, have been reported from cats, cat fleas, and humans in australia. however, to date, there has been no report of b. henselae or b. clarridgeiae in australian wild animals and their ectoparasites. ... | 2011 | 21919728 |
| bartonellae in animals and vectors in new caledonia. | bartonellae are gram-negative facultative intracellular alpha-proteobacteria from the family bartonellaceae. the natural history of bartonellae consists of a reservoir/host, which is a vertebrate with chronic intravascular infection with sustained bacteremia, and a vector (usually an arthropod) that transfers the bacteria from the reservoir to a susceptible yet uninfected host. in order to reveal the sources and reservoirs of bartonella infection in animals and vectors in new caledonia, we colle ... | 2011 | 22018646 |
| Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells. | Bacterial type IV secretion systems (T4SSs) are involved in processes such as bacterial conjugation and protein translocation to animal cells. In this work, we have switched the substrates of T4SSs involved in pathogenicity for DNA transfer. Plasmids containing part of the conjugative machinery of plasmid R388 were transferred by the T4SS of human facultative intracellular pathogen Bartonella henselae to both recipient bacteria and human vascular endothelial cells. About 2% of the human cells ex ... | 2011 | 21908662 |
| onset of cutaneous vasculitis and exacerbation of iga nephropathy after bartonella henselae infection. | bartonella henselae is the aetiological agent of cat-scratch disease. recently, there have been reports of other conditions associated with this bacterium, including leucocytoclastic vasculitis, thrombocytopenic purpura, maculopapular and urticarial eruptions, granuloma annulare, erythema nodosum, erythema marginatum and erythema annulare. we report the first case, to our knowledge, of the simultaneous occurrence of cutaneous vasculitis and nephrotic syndrome in a 65-year-old woman with iga neph ... | 2011 | 21981612 |
| Detection of Bartonella henselae IgM in serum of experimentally infected and naturally exposed cats. | Results of Bartonella henselae blood culture, polymerase chain reaction (PCR) assay on blood, or IgG antibody assays do not always correlate with the presence or absence of clinical disease in cats, and B. henselae IgG antibodies in serum do not always correlate with bacteremia. However, little is known concerning Bartonella spp. IgM antibodies in naturally exposed cats. | 2011 | 22092615 |
| [Comparison of the indirect immunofluorescence assay performance of bartonella henselae antigens obtained by co-cultivation in vero and HeLa cells]. | The laboratory diagnosis of Bartonella henselae infection is mainly based on serological testing by indirect immunofluorescence assay (IFA). Cell line co-cultivation with B.henselae and agar derivated antigens are the two major procedures used for evaluation of anti-Bartonella antibodies. Vero and Hep-2 cell lines are the most commonly used media for co-cultivation both in-house and commercial diagnostic kits production. However, HeLa cells which are easily supplied and grown, also can easily be ... | 2011 | 21935779 |
| Transmission of flea-borne zoonotic agents (*). | Flea-borne zoonoses such as plague (Yersinia pestis) and murine typhus (Rickettsia typhi) caused significant numbers of human cases in the past and remain a public health concern. Other flea-borne human pathogens have emerged recently (e.g., Bartonella henselae, Rickettsia felis), and their mechanisms of transmission and impact on human health are not fully understood. Our review focuses on the ecology and epidemiology of the flea-borne bacterial zoonoses mentioned above with an emphasis on rece ... | 2012 | 21888520 |
| comparative analysis of glutaredoxin domains from bacterial opportunistic pathogens. | glutaredoxin proteins (glxrs) are essential components of the glutathione system that reductively detoxify substances such as arsenic and peroxides and are important in the synthesis of dna via ribonucleotide reductases. nmr solution structures of glutaredoxin domains from two gram-negative opportunistic pathogens, brucella melitensis and bartonella henselae, are presented. these domains lack the n-terminal helix that is frequently present in eukaryotic glxrs. the conserved active-site cysteines ... | 2011 | 21904064 |
| comparison of the 'ca. liberibacter asiaticus' genome adapted for an intracellular lifestyle with other members of the rhizobiales. | an intracellular plant pathogen 'candidatus liberibacter asiaticus,' a member of the rhizobiales, is related to sinorhizobium meliloti, bradyrhizobium japonicum, nitrogen fixing endosymbionts, agrobacterium tumefaciens, a plant pathogen, and bartonella henselae, an intracellular mammalian pathogen. whole chromosome comparisons identified at least 50 clusters of conserved orthologous genes found on the chromosomes of all five metabolically diverse species. the intracellular pathogens 'ca. liberib ... | 2011 | 21876745 |
| presence of bartonella species in wild carnivores of northern spain. | the genus bartonella was detected by pcr in 5.7% (12/212) of wild carnivores from northern spain. based on hybridization and sequence analyses, bartonella henselae was identified in a wildcat (felis silvestris), bartonella rochalimae in a red fox (vulpes vulpes) and in a wolf (canis lupus), and bartonella sp. in badgers (meles meles). | 2011 | 22138983 |
| structure of a nudix hydrolase (mutt) in the mg(2+)-bound state from bartonella henselae, the bacterium responsible for cat scratch fever. | cat scratch fever (also known as cat scratch disease and bartonellosis) is an infectious disease caused by the proteobacterium bartonella henselae following a cat scratch. although the infection usually resolves spontaneously without treatment in healthy adults, bartonellosis may lead to severe complications in young children and immunocompromised patients, and there is new evidence suggesting that b. henselae may be associated with a broader range of clinical symptoms then previously believed. ... | 2011 | 21904053 |