| activation of endogenous mmtv proviruses in murine mammary cancer induced by chemical carcinogen. | a study was undertaken to determine whether activation of expression of silent endogenous mouse mammary tumor virus (mmtv) proviruses may occur during tumor induction by a chemical carcinogen. a series of transplantable mammary tumors induced in balb/c mice by treatment with dimethylbenz(alpha)anthracene (dmba), pituitary isograft, or both was examined. the results obtained suggest that chemical carcinogens may induce mammary tumors through more than one pathway. two of 9 tumor lines produced vi ... | 1987 | 3040604 |
| the mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice. | a series of transgenic mice was developed that contained the simian virus 40 early region genes under the transcriptional control of the mouse mammary tumor virus long terminal repeat, including the promoter and glucocorticoid response elements. these mice all expressed the transgene in the epithelial cells of a number of different organs, such as lungs, kidneys, and prostate, salivary, and mammary glands, and in leydig and lymphoid cells. transcription of the chimeric gene was inducible by gluc ... | 1987 | 3041021 |
| enhancement of tumorigenicity with morphological progression in a balb/c preneoplastic outgrowth line. | four newly established mammary hyperplastic outgrowth lines were analyzed for their tumorigenic, morphological, and ovarian hormone-dependent growth properties in balb/cmed mice. the mammary outgrowth lines were designated dim-1, dim-2, dim-3, and dim-4 to indicate their origin from the mammary cell line comma-d. dim-1, dim-2, and dim-3 were classical hyperplastic alveolar outgrowth lines that possessed high tumor-producing capabilities and rapidly evolved by transplant generation (tg) 6 into ov ... | 1987 | 3041094 |
| association of dna-bound progesterone receptors. | steroid hormone-receptor complexes regulate the transcription of specific genes. recent studies of high-affinity interactions between the receptors and discrete regions of dna, together with gene-transfer experiments, have led to the precise mapping of hormone regulatory elements. nothing is known, however, about the mechanisms whereby dna-bound receptors modulate gene transcription. at the start of transcription in prokaryotes two oligomeric molecules of several regulatory proteins must bind to ... | 1987 | 3041228 |
| expression and phenotypic alterations caused by an inducible transforming ras oncogene introduced into rat liver epithelial cells. | although transforming ras oncogenes have been implicated as causative factors in liver cell transformation, the exact function and phenotypic alterations generated by the expression of such transforming genes in liver epithelial cells has yet to be defined. we have utilized a retroviral vector system to deliver an inducible transforming ras gene into normal, anchorage dependent rat liver epithelial cells. the moloney murine sarcoma virus based vector is composed of a dominant selectable marker, ... | 1988 | 3060790 |
| disordered metabolism of microfilament proteins, tropomyosin and actin, in mouse mammary epithelial cells expressing the ha-ras oncogene. | synthesis of 37- and 41-kd tropomyosins (tm) is suppressed in fibroblasts expressing transforming oncogenes, which may contribute to the deranged microfilament structure seen in such cells (cooper et al., mol. cell. biol. 5, 972, 1985). to determine whether tm metabolism was also deranged when epithelial cells expressed a transforming oncogene, we studied cultured mouse mammary epithelial cells which express the activated c-ha-ras oncogene either constitutively or through glucocorticoid activati ... | 1988 | 3060798 |
| ras (proto)oncogene induces n-linked carbohydrate modification: temporal relationship with induction of invasive potential. | the effect of expression of the ras oncogene on protein glycosylation was studied. vsv g-protein and class i histocompatibility antigens were analysed to monitor ras-mediated changes in glycosylation. transient expression of the c-ha-ras oncogene, introduced into nih 3t3 cells by the deae-dextran method, altered protein glycosylation within 25 h of transfection. the same result was obtained after dexamethasone-induced expression of p21-ras in stable nih 3t3 transfectants containing either an act ... | 1988 | 3061796 |
| induction of transforming growth factor alpha expression in mouse mammary epithelial cells after transformation with a point-mutated c-ha-ras protooncogene. | nog-8 ras cells are a normal mouse mammary epithelial cell line transfected with a plasmid containing a glucocorticoid-inducible mouse mammary tumor virus long terminal repeat linked to the activated c-ha-ras protooncogene. after addition of dexamethasone, there is a rapid induction (within 1-3 h) of p21ras protein that is concomitant with a parallel induction of the c-ha-ras specific mrna. after 4-6 days of dexamethasone treatment, nog-8 ras cells are able to grow as colonies in semisolid mediu ... | 1988 | 3063955 |
| thrombin stimulates arachidonate metabolism in murine tumor cells. | thrombin can be formed in the tumor cell microenvironment following activation of the clotting cascade by procoagulants of cancer or host cells. we have tested here the effects of thrombin, either "endogenous" or "exogenous" (see below), on arachidonate mobilization from membrane phospholipids of mouse mammary tumor virus-induced (mmtv) carcinoma cells. these tumor cells exhibit in vitro a tissue type procoagulant activity (130 thromboplastin units/10(4) cells) and are therefore able to induce t ... | 1987 | 3102391 |
| expression of h-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10t1/2 and nih 3t3 cells. | using three independent approaches, we studied the effects of h-ras on metastasis formation. analysis of five in vitro-ras-transfected 10t1/2 clones with either flat or refractile morphologies revealed a relationship between metastatic potential, h-ras expression, and anchorage-independent growth. four metastatic variants derived from a poorly metastatic, low-h-ras-expressing line all expressed high levels of h-ras rna and grew efficiently in soft agar. activation of h-ras expression in the meta ... | 1987 | 3102946 |
| prevention of tumorigenesis of oncogene-transformed rat fibroblasts with dna site inhibitors of poly(adp ribose) polymerase. | the ej-ras gene was placed under the transcriptional control of the steroid-inducible mouse mammary tumor virus promoter/enhancer and introduced into rat-1 fibroblasts, yielding the 14c cell line. when these cells were exposed to dexamethasone in vitro, ej-ras mrna was induced 15- to 20-fold, the cells grew in agar, and, after injection of cells into syngenic fischer 344 rats, they produced lethal fibrosarcomas. inhibitors of poly(adp ribose) polymerase, which prevent the activation of the purif ... | 1987 | 3103126 |
| dexamethasone-dependent inhibition of differentiation of c2 myoblasts bearing steroid-inducible n-ras oncogenes. | ras proteins are localized to the plasma membrane where they are postulated to interact with growth factor receptors and other proximal elements in intracellular cascades triggered by growth factors. the molecular events associated with terminal differentiation of certain skeletal myoblasts are inhibited by specific polypeptide growth factors and by constitutive expression of transforming ras oncogenes. to determine whether the inhibitory effects of ras on myogenic differentiation were reversibl ... | 1988 | 3133379 |
| mechanism of dexamethasone 21-mesylate antiglucocorticoid action: i. receptor-antiglucocorticoid complexes do not competitively inhibit receptor-glucocorticoid complex activation of gene transcription in vivo. | the actions of dexamethasone 21-mesylate (dm) have been studied in two recently developed cultured murine cell lines containing approximately 200 copies of episomal minichromosome. this minichromosome contains the glucocorticoid regulatory element in the mouse mammary tumor virus long terminal repeat fused upstream of v-rash sequences in a totally defined primary sequence environment. the levels of v-rash mrna were measured as an index of glucocorticoid regulated expression of this chimeric gene ... | 1987 | 3153481 |
| expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. | transcriptional activation of the int-1 gene by proviral insertion mutations is thought to be a key step in mammary tumor induction by the mouse mammary tumor virus (mmtv). to test this hypothesis, we have constructed an int-1 allele resembling those found in virus-induced tumors, with an mmtv ltr placed 5' to the int-1 gene in the opposite transcriptional orientation. transgenic mice harboring this allele express int-1 rna at high levels in mammary and salivary glands of male and female mice an ... | 1988 | 3180222 |
| human progesterone a-receptors can be synthesized intracellularly and are biologically functional. | in order to investigate the origin and functional independence of the human progesterone receptor a binding protein, we have expressed a truncated human progesterone receptor cdna in both gene transfer and in vitro translation assays. proteins identical in size and antigenicity to the a-receptors found naturally in human progesterone target cells are synthesized from this cdna that lacks the putative b receptor initiator methionine codon of the complete cdna. the functional independence of a-rec ... | 1988 | 3196338 |
| mapping cis-dna regulatory elements in seminal vesicle secretion genes, prostate c3(1) gene, and the mouse mammary tumor virus-long terminal repeat dna. | | 1988 | 3217428 |
| immunohistochemical distribution of the 52-kda protein in mammary tumors: a marker associated with cell proliferation rather than with hormone responsiveness. | we have previously described a secreted glycoprotein of mol. wt 52,000 (52-kda protein) which is induced by estrogen in some human breast cancer cell lines. this protein has been identified as the proenzyme of a lysosomal cathepsin-d-like protease which is secreted in large proportions in breast cancer cells. to determine which information may be generated by this marker when detected in mammary tumors, in comparison with hormone receptors, we used monoclonal antibodies interacting specifically ... | 1987 | 3320536 |
| the int-1 proto-oncogene. | the int-1 proto-oncogene is the first cellular gene discovered and implicated in tumorigenesis solely on the basis of repeated insertional mutations that activate transcription of the gene. the gene is silent in most tissues but expressed in the embryonic central nervous system, in the late (post-meiotic) stages of spermatogenesis, and in a high proportion of mouse mammary tumor virus-induced carcinomas, when a provirus is inserted upstream or downstream of the coding domain. the functional sign ... | 1986 | 3332019 |
| stimulation of specific transcription and dna binding studies suggest that in vitro transformed ru 486-glucocorticosteroid receptor complexes display agonist activity. | the relative rate of ovalbumin transcription was significantly increased (p less than 0.001) when purified chick liver glucocorticosteroid receptor (gr) was incubated with purified nuclei prepared from the oviducts of diethylstilboestrol (des)-primed chickens 24 h after oestrogen withdrawal. this increase was observed whether gr was bound by the agonist triamcinolone acetonide (ta, +80.3%) or the antiglucocorticosteroid ru 486 (+89.4%). no significant increase (p greater than 0.05) in the relati ... | 1988 | 3386256 |
| the chicken progesterone receptor: sequence, expression and functional analysis. | the complete mrna sequence of the chicken progesterone receptor (cpr) has been determined. expression of the cloned cdna both in vivo and in vitro produces a protein that has the same apparent mol. wt on sds--polyacrylamide gels as the 'natural' cpr form b (109 kd) as determined by immunoblotting and photoaffinity labelling. when expressed in hela or in cos-1 cells the 'cloned' cpr displays hormone binding characteristics indistinguishable from the 'natural' receptor and, in the presence of prog ... | 1987 | 3443098 |
| the progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. | progesterone is involved in the development and progression of breast cancers, and progesterone receptors (pr) are important markers of hormone dependence and disease prognosis. we have used a human pr cdna probe, genomic dna blotting of a series of chinese hamster-human cell hybrids, and in situ hybridization to map the human pr gene to chromosome 11, band q13. this band also contains the human homolog of the mouse mammary tumor virus integration site, int-2, which surrounds a protooncogene tho ... | 1987 | 3472240 |
| polypeptides of mason-pfizer monkey virus. iii. translational order of proteins on the gag and env gene specified precursor polypeptides. | mason-pfizer monkey virus (m-pmv), the prototype d-type retrovirus, unlike most retroviruses, preassembles core structures in the cytoplasm of infected cells during morphogenesis. we have shown previously (j. bradac and e. hunter, 1984, virology 138, 260-275) that m-pmv virions contain 5 gag-encoded polypeptides. in this report, the translational order of the proteins encoded on the gag and env genes of m-pmv has been determined by pactamycin mapping. the proposed order of the viral proteins on ... | 1986 | 3485855 |
| the 52 k protein: an estrogen regulated marker of cell proliferation in human mammary cells. | | 1986 | 3515355 |
| inducible production of c-fos antisense rna inhibits 3t3 cell proliferation. | antisense rna complementary to c-fos mrna was produced in mouse 3t3 cells by gene transfer techniques. transcriptional units were constructed consisting of a steroid-inducible mouse mammary tumor virus (mmtv) promoter, mouse or human 5' c-fos gene fragments in either the sense (5' to 3') or antisense (3' to 5') orientation, and splice and poly(a) signals from the human beta-globin gene. a gene that confers neomycin resistance was included in the vectors to allow isolation of stable transformants ... | 1986 | 3523478 |
| antisense rna of proto-oncogene c-fos blocks renewed growth of quiescent 3t3 cells. | mouse 3t3 cells were transformed with an antisense c-fos gene fused to a mouse mammary tumor virus promoter. in transformants that integrated a large number of antisense c-fos sequences, the usual large increase in c-fos mrna and protein following stimulation of quiescent cells by platelet-derived growth factor was blocked in the presence of dexamethasone. these cells subsequently also failed to show the stimulation of dna synthesis normally induced by platelet-derived growth factor. appropriate ... | 1987 | 3547078 |
| expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos. | the int-1 proto-oncogene is transcriptionally activated in mammary tumors by mouse mammary tumor virus insertion mutations and is normally expressed only in adult mouse testes and mid-gestational embryos. we have used anatomical dissection of embryos, germ-cell fractionation, peripuberal expression studies, and spermatogenesis mutants to identify more precisely the tissues and cells that contain int-1 rna. in the testis, int-1 rna is detected only in postmeiotic germ cells undergoing differentia ... | 1987 | 3594566 |
| tumour-cell-induced platelet aggregation: studies with cloned metastatic and non-metastatic variants. | blood platelets have been suggested to play an important role in modulating the development of experimental metastases. tumour cells can induce platelet aggregation in vitro and a number of mechanisms have been proposed to explain the in vivo and in vitro observations. in the present study, we used tumour cells cloned from b16 melanoma and mouse mammary tumour virus (mmtv) carcinoma polyclonal populations to check whether tumour cells with low- and high-metastatic behaviour in vivo had different ... | 1987 | 3679744 |
| hydroxylamine effects on cryptogenic neoplasm development in c3h mice. | the effect of administration of hydroxylamine (ha) to male and female mice was studied because of reports suggesting an anticarcinogenic effect and an enhancement of lifespan. in this study, two c3h sublines were used: the c3h/hen which carries a germinal provirus of the mouse mammary tumor virus and the c3h/hej(+) which also carries the milk-transmitted exogenous virus. lifetime administration of 10 mm ha in the drinking water resulted in a decrease in mammary neoplasm incidence in female c3h/h ... | 1987 | 3690516 |
| transferrin mrna level in the mouse mammary gland is regulated by pregnancy and extracellular matrix. | we have isolated an almost full length cdna to transferrin from a mouse mammary tumor virus-induced tumor cdna library. on northern blots of rna isolated from liver and mammary glands, the cdna hybridized to a single band of 2.4 kilobases. the authenticity of the probe is shown further by 83% sequence homology to human cdna and identical amino acid sequence to a small cdna probe isolated from a mouse liver library. the level of transferrin mrna is very low in the glands from virgin mice, but is ... | 1987 | 3693348 |
| plasma levels of a viral protein during adjuvant treatment: reflection of murine mammary tumor status and therapeutic effect. | the mouse mammary tumor and its associated virus, mouse mammary tumor virus, were chosen to test the possibility of using plasma levels of a mr 52,000 viral glycoprotein (gp52) as a means for monitoring changes in tumor status during surgical adjuvant cyclophosphamide:doxorubicin (adriamycin):5-fluorouracil treatment. analysis of tumor recurrence and plasma gp52 concentrations during the postoperative period demonstrated that both parameters were significantly decreased in the group receiving cy ... | 1986 | 3754489 |
| immunocolloidal gold electron microscopy of viral antigens and cellular actin in c3h/he mouse mammary tumors. | mouse mammary tumor virus (mmtv) antigens and cellular actin were visualized with protein a-coated colloidal gold at the ultrastructural level in c3h/he mouse mammary tumors using various antisera. observations with the postembedding method and statistical analyses of these data showed: (a) a glycoprotein with a molecular weight of 52,000 resided on the envelope of mature virions (b-particles), on the surface of budding particles, and on the vacuolar membrane, but not on intracytoplasmic a-parti ... | 1986 | 3756926 |
| in vitro differentiation and progression of mouse mammary tumor cells. | we have isolated clonal cell lines from a transplanted adenocarcinoma induced by the riii strain of mouse mammary tumor virus in a balb/c mouse. three major morphological cell types of these lines are developmentally linked; polygonal cells give rise to cuboidal and then to elongated cells. all cell lines expressed markers that are characteristic of mammary basal cells. in addition, the polygonal lines contained cells that have cell markers and ultrastructural features of epithelial cells; in th ... | 1986 | 3756929 |
| nucleotide sequence analysis of the long terminal repeat of integrated caprine arthritis encephalitis virus. | the nucleotide sequence of the long terminal repeat (ltr) of caprine arthritis encephalitis virus (caev), a prototype lentivirus was determined. 6-bp directly repeated host cell sequences flank the 376-bp proviral ltrs. by comparison with other retroviral sequences, the caev ltr likely contains u3, r and u5 regions 207, 86 and 83 base-pairs in length, respectively. sequences conforming to consensus transcriptional promoter sites were identified in the u3 region upstream of a potential transcript ... | 1986 | 3765821 |
| highly recurring sequence elements identified in eukaryotic dnas by computer analysis are often homologous to regulatory sequences or protein binding sites. | we have used computer assisted dot matrix and oligonucleotide frequency analyses to identify highly recurring sequence elements of 7-11 base pairs in eukaryotic genes and viral dnas. such elements are found much more frequently than expected, often with an average spacing of a few hundred base pairs. furthermore, the most abundant repetitive elements observed in the ovalbumin locus, the beta-globin gene cluster, the metallothionein gene and the viral genomes of sv40, polyoma, herpes simplex-1 an ... | 1987 | 3822840 |
| therapeutic effect reflected by plasma levels of a viral protein during combination chemotherapeutic treatment of mammary tumor-bearing mice. | plasma concentrations of gp52, a mr 52,000 glycoprotein of the mouse mammary tumor virus, have been measured during cyclophosphamide, doxorubicin (adriamycin) and 5-fluorouracil (caf) treatment of mammary tumor-bearing cd8f1 mice. the value of plasma concentrations of gp52 as an indicator of caf-mediated changes in tumor status was supported by each of the following findings: (a) caf treatment did not interfere with the detection of elevated viral antigen levels in the plasma of tumor-bearing mi ... | 1985 | 3840411 |
| ectopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinomas. | some endocrinological consequences of grafting hypophyses of mice to sites distant from the hypothalamic-pituitary portal vessels were investigated. serum prl levels in recipients rose within 3 weeks to levels seen during pregnancy, resulting in a premature increase in serum progesterone (p) levels. after 7 weeks, luteolytic effects were evident in balb/c females, and p values had plateaued in the range of those seen in normal adult animals, while in balb/c x c3h f1 hybrids, this effect was dela ... | 1985 | 3971922 |
| mammary-tumor virion structures in mouse milk fractions. | | 1969 | 4097046 |
| identification of the nucleic acid of mouse mammary tumor virus (mtv) using fluorescence microscopy. | | 1970 | 4099980 |
| ultrastructural and quantitative studies of mammary tumor virus production in cultured mouse mammary tumor cells. | | 1970 | 4100959 |
| a virus in human breast cancer? | | 1971 | 4101437 |
| human breast-cancer virus and artificial feeding of babies. | | 1971 | 4102299 |
| demonstration by the antiglobulin consumption test with murine antisera of common antigens in tissues infected with the mammary tumor virus from different mouse strains. | | 1971 | 4107242 |
| characteristics of the structural components of the mouse mammary tumor virus. i. morphological and biochemical studies. | | 1971 | 4108031 |
| helical nucleocapsid structure of the oncogenic ribonucleic acid viruses (oncornaviruses). | negative staining of virions and isolated nucleoids from avian myeloblastosis virus, murine leukemia virus, murine mammary tumor virus, and feline leukemia virus reveals common internal structures. the majority of virions that are penetrated by phosphotungstate show spherical nucleoids with no apparent symmetry. in a small percentage of virions, two distinctive structures are found: (i) single strands (3 to 5 nm in diameter) which are presumed to be the nucleoprotein and are found randomly orien ... | 1971 | 4108573 |
| [immunology of mammary cancer in mice]. | | 1971 | 4110762 |
| binding of concanavalin a to the envelope of two murine rna tumour viruses. | | 1972 | 4110930 |
| regression of spontaneous mammary carcinomas using direct injections of neuraminidase and bcg. | | 1972 | 4111004 |
| electron microscopy in mammary cancer research. | | 1972 | 4112452 |
| electron microscopy of cell transformation by r-35 rat virus and comparative morphology with other oncogenic viruses. | | 1972 | 4112453 |
| comparative studies on monolayer and suspension cell cultures from a transplantable rat mammary carcinoma containing c-tye virus particles. | | 1971 | 4112478 |
| [is the breast carcinoma of the female caused by a virus?]. | | 1972 | 4114024 |
| gel electrophoresis of reverse transcriptase activity of murine mammary tumour virions. | | 1972 | 4117769 |
| particles containing rna-instructed dna polymerase and virus-related rna in human breast cancers. | human breast cancers contain an rna related to that of mouse mammary tumor virus. in 79% of the breast malignancies examined, this type of rna is a 70s-component encapsulated with rna-instructed dna polymerase in a particle possessing the density characteristics of rna tumor viruses. further, the dna synthesized by the human rna enzyme complex hybridizes specifically with the rna of mouse mammary tumor virus. thus, four features diagnostic of agents similar to mouse mammary tumor virus are also ... | 1972 | 4117770 |
| human leukaemic cells contain reverse transcriptase associated with a high molecular weight virus-related rna. | | 1972 | 4117891 |
| studies on the acid mucopolysaccharide coat of viruses and transformed cells. | | 1973 | 4118912 |
| effect of human milk on the mouse mammary tumor virus. | | 1973 | 4120354 |
| remarks on virus-like particles in human breast cancer. | | 1973 | 4121275 |
| homology between rna from human malignant breast tissue and dna synthesized by milk particles. | | 1972 | 4121809 |
| oncogenicity of mammary tumor viruses. | | 1972 | 4122068 |
| detection of tumour-associated transplantation antigen of bo-iv carcinoma on somatic cells of tumour-free syngeneic mice. ii. search for a common antigen in some organs and spontaneous mammary carcinomas. | | 1973 | 4122838 |
| further evidence for oncornaviruses in human milk: the production of cores. | cores, or nucleoids, have been isolated from particles in human milk. the cores have a density of 1.26-1.27 g/ml and contain a 60-70s rna in association with an rna-instructed dna polymerase. the data offer further evidence of similarity between human milk particles and animal rna tumor viruses. in addition, core isolation provides a new method for detection of these particles by minimizing the difficulties generated by the presence of cell-associated debris often found in the density region (1. ... | 1973 | 4124682 |
| characterization and separation of viral dna polymerase in mouse milk. | two dna polymerase with properties of viral rna-directed dna polymerase can be found in riii mouse milk. one enzyme is the polymerase of type-c viruses; this enzyme prefers manganese to magnesium with poly(ra).oligo(dt) as synthetic template, is inhibited by specific sera, and has an apparent molecular weight of 70,000. milk from balb/c and nih swiss mice contain a vast predominance of this type-c enzyme. the other dna polymerase from riii mouse milk prefers magnesium to manganese, is not inhibi ... | 1973 | 4124683 |
| size, shape and surface structure of mouse mammary tumour virus (mtv). brief report. | | 1973 | 4125536 |
| human mammary tumor virus. | | 1973 | 4125984 |
| [reverse transcription and its significance in genetics and oncology]. | | 1973 | 4126002 |
| in vitro production of mouse mammary tumor virus in a mouse mammary tumor ascites line. | an ascites line derived from a spontaneous mouse mammary carcinoma produces, on explantation and cultivation in vitro, large amounts of oncornavirus particles. the biochemical, biophysical, and electron microscopic characteristics of the virions are described. molecular hybridization and immunological methods identify these virions as mouse mammary tumor virus. | 1973 | 4126729 |
| mouse mammary tumour virus rna-dependent dna polymerase: requirements and products. | | 1973 | 4127734 |
| [rna viruses as a cause of cancer]. | | 1973 | 4129093 |
| rna tumor viruses present in growing and absent in regressing mammary tumors of mice. | | 1974 | 4129834 |
| viruses and breast cancer: implications of mouse and human studies. | | 1974 | 4129845 |
| reverse transcriptase-progress, problems and prospects. | | 1973 | 4130390 |
| reverse transcriptases of rna tumor viruses: immunological relationships. | | 1973 | 4130394 |
| production of an oncornavirus by the continuous human cell line, detroit-6. | | 1974 | 4131426 |
| oncornavirus-like particles in hela cells. ii. immunological characterization of the virus. | | 1974 | 4131731 |
| investigations on reverse-transcribed dna from rna templates. | | 1974 | 4132651 |
| localization of intracytoplasmic a particles in mouse tumors by light microscopy. | | 1974 | 4133188 |
| quantitative studies on intracytoplasmic a particles formed in dba-2 mouse leukemias. | | 1974 | 4133189 |
| a determination of the outer dimensions of oncornaviruses by several electron microscopic procedures. | | 1974 | 4134292 |
| isolation and characterization of rna-directed dna polymerase from a b-type rna tumor virus. | rna-directed dna polymerase was isolated from milk-borne b-type murine mammary tumor virus of the riii mouse strain. the several hundred-fold-purified enzyme sediments at 5.5 to 5.7s with an average molecular weight of approximately 100,000. the purified enzyme is completely template dependent and responds to rna, dna, and synthetic templates. stability studies indicate differential lability dependent on the exogenous template used to monitor activity. | 1974 | 4134465 |
| physical and chemical properties of an oncornavirus associated with a murine adrenal carcinoma cell line. | a type c oncornavirus has been isolated from a continuous cell line of murine adrenal carcinoma in culture. the particles have a buoyant density of 1.165 g/cm(3), exhibit typical type c morphology by electron microscopy, possess an rna-dependent dna polymerase, and have a high molecular weight rna (6.1 x 10(6)) which can be denatured to a homogeneous lower molecular weight species (3.2 x 10(6)) when extracted from rapidly harvested "immature" virions. the virus is related antigenically to other ... | 1974 | 4134466 |
| enhanced production of mouse mammary tumor virus in dexamethasone-treated, 5-iododeoxyuridine-stimulated mammary tumor cell cultures. | | 1974 | 4134501 |
| proceedings: search for a viral etiology of human breast cancer. | | 1974 | 4134904 |
| mammary carcinogenesis in foster-nursed x-gf mice. | | 1974 | 4135681 |
| evidence in favor of the existence of human breast cancer virus. | | 1974 | 4135684 |
| breast cancer: molecular basis for a viral etiology. | | 1974 | 4136572 |
| an attempt to correlate rna-templated dna polymerase activity with virus-like particles in human milk: murine mammary tumor virus (mumtv) as a model system. | | 1973 | 4137532 |
| surface structure of mouse mammary tumor virus. | | 1974 | 4137957 |
| the relevance of rna tumor viruses to human cancer. | | 1973 | 4137999 |
| conditions for optimal mtv synthesis in vitro and the effect of steroid hormones on virus production. | | 1974 | 4138556 |
| the relationship of visna, maedi and rna tumor viruses as studied by molecular hybridization. | | 1973 | 4139807 |
| structural components of rna tumor viruses. | | 1974 | 4140684 |
| in vitro system for production of mouse mammary tumor virus. | an in vitro system for production, purification, and concentration of mouse mammary tumor virus is described. monolayer cultures of c(3)h mouse mammary tumor cells propagated at 34 c in roller bottles in the presence of dexamethasone, a glucocorticoid hormone, release b-type particles which possess ribonucleic acid and a ribonucleic acid-dependent deoxyribonucleic acid polymerase. one thousandfold concentration by ultracentrifugation with subsequent gradient fractionation yielded > 7 x 10(10) pa ... | 1974 | 4141598 |
| host-virus interactions in murine mammary carcinogenesis. | | 1974 | 4142395 |
| inhibition of growth of mouse mammary carcinoma by streptovaricin. | | 1974 | 4151254 |
| electron microscopic localization of viral antigens in mouse mammary tumors by ferritin-labeled antibody. i. the homologous systems. | | 1967 | 4167868 |
| a morphological comparison of bittner and influenza viruses. | | 1967 | 4169363 |
| direct cell to cell transfer of bittner virus. | | 1970 | 4192489 |
| type b particles in human milk. | | 1969 | 4192746 |
| morphogenesis of bittner virus. | the morphogenesis of bittner virus (mouse mammary tumor virus) was studied in sectioned mammary tumor cells. internal components of the virus (type a particles) were seen being assembled in virus factories close to the nucleus and were also seen forming at the plasma membrane. the particles in virus factories became enveloped by budding through the membrane of cytoplasmic vacuoles which were derived from dilated endoplasmic reticulum. complete virus particles were liberated from these vacuoles b ... | 1970 | 4193837 |
| isopycnic zonal centrifugation and characterization of the mouse mammary tumor virus (mtv) in different gradient solutions. | | 1970 | 4194176 |